Additivity of mutational effects in proteins.


Abstract

Study holds ProTherm entries: 4181, 4182, 4183 Extra Details: additivity; mutational effects; protein stability

Submission Details

ID: z6NUPnhi3

Submitter: Connie Wang

Submission Date: April 24, 2018, 8:24 p.m.

Version: 1

Publication Details
Wells JA,Biochemistry (1990) Additivity of mutational effects in proteins. PMID:2271534
Additional Information

Structure view and single mutant data analysis

Study data

No weblogo for data of varying length.
Colors: D E R H K S T N Q A V I L M F Y W C G P
 

Data Distribution

Studies with similar sequences (approximate matches)

Correlation with other assays (exact sequence matches)


Relevant PDB Entries

Structure ID Release Date Resolution Structure Title
1TPM 1994-01-31 SOLUTION STRUCTURE OF THE FIBRIN BINDING FINGER DOMAIN OF TISSUE-TYPE PLASMINOGEN ACTIVATOR DETERMINED BY 1H NUCLEAR MAGNETIC RESONANCE
1TPG 1995-09-15 F1-G MODULE PAIR RESIDUES 1-91 (C83S) OF TISSUE-TYPE PLASMINOGEN ACTIVATOR (T-PA) (NMR, 298K, PH2.95, REPRESENTATIVE STRUCTURE)
1TPN 1994-01-31 SOLUTION STRUCTURE OF THE FIBRIN BINDING FINGER DOMAIN OF TISSUE-TYPE PLASMINOGEN ACTIVATOR DETERMINED BY 1H NUCLEAR MAGNETIC RESONANCE
1PK2 1994-01-31 SOLUTION STRUCTURE OF THE TISSUE-TYPE PLASMINOGEN ACTIVATOR KRINGLE 2 DOMAIN COMPLEXED TO 6-AMINOHEXANOIC ACID AN ANTIFIBRINOLYTIC DRUG
1RTF 1997-01-11 2.3 COMPLEX OF BENZAMIDINE WITH THE CATALYTIC DOMAIN OF HUMAN TWO CHAIN TISSUE PLASMINOGEN ACTIVATOR [(TC)-T-PA]
1PML 1994-06-22 2.38 KRINGLE-KRINGLE INTERACTIONS IN MULTIMER KRINGLE STRUCTURES
1TPK 1992-07-15 2.4 CRYSTAL STRUCTURE OF THE KRINGLE-2 DOMAIN OF TISSUE PLASMINOGEN ACTIVATOR AT 2.4-ANGSTROMS RESOLUTION
1A5H 1999-04-20 2.9 CATALYTIC DOMAIN OF HUMAN TWO-CHAIN TISSUE PLASMINOGEN ACTIVATOR COMPLEX OF A BIS-BENZAMIDINE
5BRR 2015-09-02 3.16 Michaelis complex of tPA-S195A:PAI-1
1BDA 1999-05-11 3.35 CATALYTIC DOMAIN OF HUMAN SINGLE CHAIN TISSUE PLASMINOGEN ACTIVATOR IN COMPLEX WITH DANSYL-EGR-CMK (DANSYL-GLU-GLY-ARG CHLOROMETHYL KETONE)
5ZLZ 2019-04-03 3.58 Structure of tPA and PAI-1

Relevant UniProtKB Entries

Percent Identity Matching Chains Protein Accession Entry Name
97.9 Tissue-type plasminogen activator Q5R8J0 TPA_PONAB
100.0 Tissue-type plasminogen activator P00750 TPA_HUMAN