Ubiquitin folds through a highly polarized transition state.


Abstract

The small alpha/beta protein ubiquitin has been used as a model system for experimental and computational studies on protein folding for many years. Here, we present a comprehensive phi-value analysis and characterize the structure and energetics of the transition state ensemble (TSE). Twenty-seven non-disruptive mutations are made throughout the structure and a range of phi-values from zero to one are observed. The values cluster such that medium and high values and found only in the N-terminal region of the protein, whilst the C-terminal region has consistently low phi-values. In the TSE, the main alpha-helix appears to be fully formed (two phi-values which specifically probe helical structure are one) and the helix is stabilized by packing against the first beta-turn, which is partially structured. In striking comparison, the phi-values in the C-terminal region are all very low, suggesting that this region of the protein is largely unstructured in the TSE. Data are consistent with a nucleation-condensation mechanism in which there is a highly polarized folding nucleus comprising the first beta-hairpin and the alpha-helix. Data presented from the protein engineering study and phi-value analysis are compared with results from other experimental studies and also computational studies.

Submission Details

ID: xaYtStP24

Submitter: Connie Wang

Submission Date: Aug. 9, 2017, 12:43 p.m.

Version: 1

Publication Details
Went HM;Jackson SE,Protein Eng Des Sel (2005) Ubiquitin folds through a highly polarized transition state. PMID:15857839
Additional Information

Structure view and single mutant data analysis

Study data

No weblogo for data of varying length.
Colors: D E R H K S T N Q A V I L M F Y W C G P
 

Data Distribution

Studies with similar sequences (approximate matches)

Correlation with other assays (exact sequence matches)


Relevant PDB Entries

Structure ID Release Date Resolution Structure Title
2KWV 2010-10-06 Solution Structure of UBM1 of murine Polymerase iota in Complex with Ubiquitin
2JRI 2008-07-01 Solution structure of the Josephin domain of Ataxin-3 in complex with ubiquitin molecule.
2MJB 2014-03-26 Solution nmr structure of ubiquitin refined against dipolar couplings in 4 media
2PE9 2007-07-10 NMR Based Structure of the Open Conformation of LYS48-Linked Di-UBiquitin Using Experimental Global Rotational Diffusion Tensor from NMR Relaxation Measurements
2K8C 2009-05-05 Solution structure of PLAA family ubiquitin binding domain (PFUC) trans isomer in complex with ubiquitin
2KX0 2010-09-08 the solution structure of UBB+1, frameshift mutant of ubiquitin B
2MSG 2015-02-18 Solid-state NMR structure of ubiquitin
6QF8 2019-04-10 Solution NMR ensemble for human ubiquitin at 298K compiled using the CoMAND method
2RU6 2014-02-12 The pure alternative state of ubiquitin
5UJN 2018-08-08 Representative 2-conformer ensembles of K27-linked Ub2 from RDC data
2KDF 2009-09-01 NMR structure of minor S5a (196-306):K48 linked diubiquitin species
6N13 2018-11-28 UbcH7-Ub Complex with R0RBR Parkin and phosphoubiquitin
2K6D 2008-08-19 CIN85 Sh3-C domain in complex with ubiquitin
2KWU 2010-10-06 Solution Structure of UBM2 of murine Polymerase iota in Complex with Ubiquitin
5YMY 2019-03-13 The structure of the complex between Rpn13 and K48-diUb
2KHW 2010-02-23 Solution Structure of the human Polymerase iota UBM2-Ubiquitin Complex
1Q0W 2003-10-07 Solution structure of Vps27 amino-terminal UIM-ubiquitin complex
2MCN 2014-02-05 Distinct ubiquitin binding modes exhibited by SH3 domains: molecular determinants and functional implications
2L3Z 2011-02-16 Proton-Detected 4D DREAM Solid-State NMR Structure of Ubiquitin
2JWZ 2008-01-08 Mutations in the hydrophobic core of ubiquitin differentially affect its recognition by receptor proteins
2LZ6 2013-10-02 Distinct ubiquitin binding modes exhibited by sh3 domains: molecular determinants and functional implications
6JLT 2019-03-20 The partially disordered conformation of ubiquitin (Q41N variant)
2MOR 2014-06-25 A tensor-free method for the structural and dynamical refinement of proteins using residual dipolar couplings
2PEA 2007-07-10 NMR Based Structure of the Closed Conformation of LYS48-Linked Di-Ubiquitin Using Experimental Global Rotational Diffusion Tensor from NMR Relaxation Measurements
2JT4 2007-09-25 Solution Structure of the Sla1 SH3-3-Ubiquitin Complex
2K39 2008-06-24 Recognition dynamics up to microseconds revealed from RDC derived ubiquitin ensemble in solution
1UD7 1999-05-06 SOLUTION STRUCTURE OF THE DESIGNED HYDROPHOBIC CORE MUTANT OF UBIQUITIN, 1D7
2N2K 2015-07-08 Ensemble structure of the closed state of Lys63-linked diubiquitin in the absence of a ligand
5XBO 2017-05-31 Lanthanoid tagging via an unnatural amino acid for protein structure characterization
2N3U 2016-02-24 Solution structure of the Rpn1 T1 site engaging two monoubiquitin molecules
2NBD 2016-05-18 Solution structure of V26A mutant of Ubiquitin at pH 6.0
1XQQ 2005-02-08 Simultaneous determination of protein structure and dynamics
2MJ5 2014-04-09 Structure of the UBA Domain of Human NBR1 in Complex with Ubiquitin
2MUR 2014-12-03 Solution Structure of the Human FAAP20 UBZ-Ubiquitin Complex
2KOX 2011-06-08 NMR residual dipolar couplings identify long range correlated motions in the backbone of the protein ubiquitin
1ZW7 2006-05-16 Elimination of the C-cap in Ubiquitin Structure, Dynamics and Thermodynamic Consequences
2LVO 2012-11-21 Structure of the gp78CUE domain bound to monubiquitin
2NBE 2016-05-18 Solution structure of V26A mutant of Ubiquitin at pH 2.0
2KTF 2010-11-03 Solution NMR structure of human polymerase iota UBM2 in complex with ubiquitin
2RSU 2013-03-27 Alternative structure of Ubiquitin
2DEN 2006-06-13 Solution Structure of the Ubiquitin-Associated Domain of Human BMSC-UbP and its Complex with Ubiquitin
1G6J 2001-03-28 STRUCTURE OF RECOMBINANT HUMAN UBIQUITIN IN AOT REVERSE MICELLES
2LJ5 2012-07-18 Description of the Structural fluctuations of proteins from structure-based calculations of Residual dipolar couplings
2MRE 2014-10-22 NMR structure of the Rad18-UBZ/ubiquitin complex
2K8B 2009-05-05 Solution structure of PLAA family ubiquitin binding domain (PFUC) cis isomer in complex with ubiquitin
2N3W 2016-02-24 Solution structure of the Rpn1 T1 site with K48-linked diubiquitin in the contracted binding mode
5VEY 2017-05-17 Solution NMR structure of histone H2A-H2B mono-ubiquitylated at H2A Lys15 in complex with RNF169 (653-708)
2Z59 2008-05-20 Complex Structures of Mouse Rpn13 (22-130aa) and ubiquitin
2LD9 2011-06-08 Backbone Structure of Ubiquitin determined using Backbone amide NOEs and Backbone N-H and N-C RDCs
1V81 2005-02-15 Solution structures of ubiquitin at 30 bar and 3 kbar
2BGF 2005-08-31 NMR structure of Lys48-linked di-ubiquitin using chemical shift perturbation data together with RDCs and 15N-relaxation data
1D3Z 1999-10-14 UBIQUITIN NMR STRUCTURE
2L0F 2010-11-03 Solution NMR structure of human polymerase iota UBM2 (P692A mutant) in complex with ubiquitin
1YX6 2005-04-19 Solution Structure of S5a UIM-2/Ubiquitin Complex
1ZGU 2006-04-04 Solution structure of the human Mms2-Ubiquitin complex
2K25 2008-09-30 Automated NMR Structure of the UBB by FAPSY
2MRO 2015-02-04 Structure of the complex of ubiquitin and the UBA domain from DNA-damage-inducible 1 protein (Ddi1)
5VZM 2018-05-23 Solution NMR structure of human Rev1 (932-1039) in complex with ubiquitin
1Q5W 2004-03-30 Ubiquitin Recognition by Npl4 Zinc-Fingers
5XK4 2017-06-28 Retracted state of S65-phosphorylated ubiquitin
1OTR 2003-06-24 Solution Structure of a CUE-Ubiquitin Complex
2MWS 2015-03-25 Structure of the complex of ubiquitin and the ubiquitin-like (UBL) domain of Ddi1
5ZD0 2019-08-21 Solution structure of human ubiquitin with three alanine mutations in living eukaryotic cells by in-cell NMR spectroscopy
2MBB 2014-06-04 Solution Structure of the human Polymerase iota UBM1-Ubiquitin Complex
2JY6 2008-03-18 Solution structure of the complex of ubiquitin and ubiquilin 1 UBA domain
2MBQ 2013-09-04 K11-linked Diubiquitin average solution structure at pH 6.8, 150 mM NaCl
2L0T 2010-12-15 Solution structure of the complex of ubiquitin and the VHS domain of Stam2
1YX5 2005-04-19 Solution Structure of S5a UIM-1/Ubiquitin Complex
1V80 2005-02-15 Solution structures of ubiquitin at 30 bar and 3 kbar
2KDI 2010-02-09 Solution structure of a Ubiquitin/UIM fusion protein
2G3Q 2006-05-09 Solution Structure of Ede1 UBA-ubiquitin complex
1GJZ 2001-12-13 Solution structure of a dimeric N-terminal fragment of human ubiquitin
2L00 2011-07-20 Solution structure of the non-covalent complex of the ZNF216 A20 domain with ubiquitin
5XK5 2017-06-28 Relaxed state of S65-phosphorylated ubiquitin
1FXT 2001-10-10 STRUCTURE OF A CONJUGATING ENZYME-UBIQUITIN THIOLESTER COMPLEX
2KN5 2009-11-17 A Correspondence Between Solution-State Dynamics of an Individual Protein and the Sequence and Conformational Diversity of its Family
2KDE 2009-09-01 NMR structure of major S5a (196-306):K48 linked diubiquitin species
5VF0 2017-05-17 Solution NMR structure of human RAD18 (198-240) in complex with ubiquitin
2MBO 2013-09-04 K11-linked Diubiquitin average solution structure at pH 6.8, 0 mM NaCl
2RR9 2011-07-06 The solution structure of the K63-Ub2:tUIMs complex
2FUH 2006-03-28 Solution Structure of the UbcH5c/Ub Non-covalent Complex
1WR1 2005-04-19 The complex sturcture of Dsk2p UBA with ubiquitin
2JZZ 2008-03-25 Solid-State NMR Structure of Microcrystalline Ubiquitin
1E0Q 2001-01-16 Mutant Peptide from the first N-terminal 17 amino-acid of Ubiquitin
2LVP 2012-11-21 gp78CUE domain bound to the distal ubiquitin of K48-linked diubiquitin
2LVQ 2012-11-21 gp78CUE domain bound to the proximal ubiquitin of K48-linked diubiquitin
2MI8 2014-04-02 Solution structure of lysine-free (K0) ubiquitin
2N3V 2016-02-24 Solution structure of the Rpn1 T1 site with K48-linked diubiquitin in the extended binding mode
2KJH 2009-12-08 NMR based structural model of the UBCH8-UBIQUITIN complex
2N13 2016-03-09 Complex structure of MyUb (1080-1122) of human Myosin VI with K63-diUb
2NR2 2007-05-08 The MUMO (minimal under-restraining minimal over-restraining) method for the determination of native states ensembles of proteins
2KLG 2009-10-06 PERE NMR structure of ubiquitin
1C3T 1999-08-20 ROTAMER STRAIN AS A DETERMINANT OF PROTEIN STRUCTURAL SPECIFICITY
2MBH 2013-10-09 NMR structure of EKLF(22-40)/Ubiquitin Complex
5UJL 2017-10-25 Representative 1-conformer ensembles of K27-linked Ub2 from RDC data
5NVG 2017-05-31 1.07 Thr12 Phosphorylated Ubiquitin
5TOG 2017-05-24 1.08 Room temperature structure of ubiquitin variant u7ub25.2540
5TOF 2017-05-24 1.12 Room temperature structure of ubiquitin variant u7ub25
5GOD 2016-11-02 1.15 Lys27-linked di-ubiquitin
4XOF 2015-10-14 1.15 Observing the overall rocking motion of a protein in a crystal - Orthorhombic Ubiquitin crystals without Zinc.
5GOB 2016-11-02 1.15 Lys6-linked di-ubiquitin
5W46 2017-07-05 1.18 Structure of S65D Phosphomimetic Ubiquitin Refined at 1.2 Angstroms Resolution
3A9J 2009-12-08 1.18 Crystal structure of the mouse TAB2-NZF in complex with Lys63-linked di-ubiquitin
5XVE 2018-02-28 1.24 Crystal structure of human USP2 C276S mutant in complex with ubiquitin
3NHE 2010-06-30 1.26 High Resolution Structure (1.26A) of USP2a in Complex with Ubiquitin
5NL4 2017-04-26 1.32 Crystal structure of Zn1.3-E16V human ubiquitin (hUb) mutant adduct, from a solution 35 mM zinc acetate/1.3 mM E16V hUb
1OGW 2003-05-30 1.32 Synthetic Ubiquitin with fluoro-Leu at 50 and 67
5DK8 2015-12-16 1.32 Human ubiquitin in the P1 space group
2GBJ 2006-05-16 1.35 Crystal Structure of the 9-10 8 Glycine Insertion Mutant of Ubiquitin.
2ZCC 2007-11-20 1.4 Ubiquitin crystallized under high pressure
3A9K 2009-12-08 1.4 Crystal structure of the mouse TAB3-NZF in complex with Lys63-linked di-ubiquitin
4HK2 2012-11-21 1.4 U7Ub25.2540
4Y1H 2015-03-18 1.4 Crystal structure of K33 linked tri-Ubiquitin
3AI5 2010-09-29 1.4 Crystal structure of yeast enhanced green fluorescent protein-ubiquitin fusion protein
2WWZ 2009-11-24 1.4 TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked di-ubiquitin, P212121
4M0W 2014-02-12 1.4 Crystal Structure of SARS-CoV papain-like protease C112S mutant in complex with ubiquitin
5V1Y 2017-05-03 1.42 Crystal structure of the ternary RPN13 PRU-RPN2 (940-953)-ubiquitin complex
5KYC 2017-08-09 1.43 Crystal structure of USP7 catalytic domain [V302K] mutant in complex with ubiquitin (malonate bound)
5KYF 2017-08-09 1.45 Crystal structure of USP7 catalytic domain [L299A] mutant in complex with ubiquitin
4IUM 2013-02-13 1.45 Equine arteritis virus papain-like protease 2 (PLP2) covalently bound to ubiquitin
1XD3 2004-11-23 1.45 Crystal structure of UCHL3-UbVME complex
6E2B 2018-11-14 1.45 Ubiquitin in complex with Pt(2-phenilpyridine)(PPh3)
4PIH 2014-10-29 1.5 X-ray crystal structure of the K33S mutant of ubiquitin
5NLF 2017-05-03 1.5 Crystal structure of Zn2.7-E16V human ubiquitin (hUb) mutant adduct, from a solution 100 mM zinc acetate/1.3 mM E16V hUb
5YT6 2018-07-11 1.5 Crystal structure of TAX1BP1 UBZ2 in complex with mono-ubiquitin
4PIJ 2014-10-29 1.5 X-ray crystal structure of the K11S/K63S double mutant of ubiquitin
4UN2 2014-08-27 1.51 Crystal structure of the UBA domain of Dsk2 in complex with Ubiquitin
5NLJ 2017-04-26 1.53 Crystal structure of Zn3-E16V human ubiquitin (hUb) mutant adduct, from a solution 70 mM zinc acetate/20% v/v TFE/1.3 mM E16V hUb
4V3L 2015-04-08 1.53 RNF38-UB-UbcH5B-Ub complex
5NLI 2017-05-03 1.53 Crystal structure of Zn2-E16V human ubiquitin (hUb) mutant adduct, from a solution 35 mM zinc acetate/10% v/v TFE/1.3 mM E16V hUb
4ZPZ 2015-06-10 1.54 Crystal Structure of Semi-synthetic Ubiquitin with Phospho-Ser65 and Ala46Cys
5J8P 2016-05-18 1.55 Lys27-linked diubiquitin
2GBM 2006-05-16 1.55 Crystal Structure of the 35-36 8 Glycine Insertion Mutant of Ubiquitin
3BY4 2008-02-19 1.55 Structure of Ovarian Tumor (OTU) domain in complex with Ubiquitin
5K9P 2016-07-20 1.55 Ser20 phosphorylated ubiquitin
5GOJ 2016-11-02 1.55 Lys63-linked di-ubiquitin
4LJO 2013-10-16 1.56 Structure of an active ligase (HOIP)/ubiquitin transfer complex
5GOI 2016-11-02 1.59 Lys48-linked di-ubiquitin
2ZNV 2008-09-02 1.6 Crystal structure of human AMSH-LP DUB domain in complex with Lys63-linked ubiquitin dimer
3M3J 2010-03-23 1.6 A new crystal form of Lys48-linked diubiquitin
2ZCB 2007-11-20 1.6 Crystal Structure of ubiquitin P37A/P38A
5OXH 2017-11-22 1.6 C-terminally retracted ubiquitin T66V/L67N mutant
2GBN 2006-05-16 1.6 Crystal Structure of the 35-36 8 Glycine Insertion Mutant of Ubiquitin
6FDK 2018-08-15 1.6 Structure of Chlamydia trachomatis effector protein Cdu1 bound to ubiquitin
5KYD 2017-08-09 1.62 Crystal structure of USP7 catalytic domain [V302K] mutant in complex with ubiquitin
4K1R 2014-04-23 1.63 Crystal structure of Schizosaccharomyces pombe sst2 catalytic domain and Ubiquitin
5OXI 2017-11-22 1.63 C-terminally retracted ubiquitin L67S mutant
6HEI 2019-03-27 1.64 Structure of the catalytic domain of USP28 (insertion deleted) bound to Ubiquitin-PA
4XYZ 2015-03-18 1.65 Crystal structure of K33 linked di-Ubiquitin
5X3N 2017-04-12 1.65 Crystal structure of DiUb-K6
5EMZ 2016-11-16 1.66 Crystal structure of K48-linked diubiquitin with F45W mutation in the proximal unit
5AF5 2015-03-25 1.68 Structure of Lys33-linked triUb S.G. P 212121
3B08 2011-12-14 1.7 Crystal structure of the mouse HOIL1-L-NZF in complex with linear di-ubiquitin
6A42 2018-10-24 1.7 R1EN(5-223)-ubiquitin fusion
3V6C 2012-12-19 1.7 Crystal Structure of USP2 in complex with mutated ubiquitin
6HPR 2018-12-12 1.7 Crystal structure of cIAP1 RING domain bound to UbcH5B-Ub and a non-covalent Ub
1P3Q 2003-06-24 1.7 Mechanism of Ubiquitin Recognition by the CUE Domain of VPS9
6B7M 2018-04-18 1.7 Crystal structure of Legionella effector sdeD (lpg2509) in complex with Ubiquitin
4I6N 2013-05-29 1.7 Crystal structure of Trichinella spiralis UCH37 catalytic domain bound to Ubiquitin vinyl methyl ester
1BT0 1998-12-30 1.7 STRUCTURE OF UBIQUITIN-LIKE PROTEIN, RUB1
5NMC 2017-05-03 1.7 Crystal structure of Zn3-hUb(human ubiquitin) adduct from a solution 70 mM zinc acetate/20% v/v TFE/1.3 mM hUb
3VUX 2013-02-13 1.7 Crystal structure of A20 ZF7 in complex with linear ubiquitin, form II
2D3G 2005-12-20 1.7 Double sided ubiquitin binding of Hrs-UIM
3NS8 2011-07-20 1.71 Crystal structure of an open conformation of Lys48-linked diubiquitin at pH 7.5
4ZFR 2015-10-14 1.72 Catalytic domain of Sst2 F403A mutant bound to ubiquitin
6EI1 2018-03-07 1.73 Crystal structure of the covalent complex between deubiquitinase ZUFSP (ZUP1) and Ubiquitin-PA
5GOC 2016-11-02 1.73 Lys11-linked diubiquitin
6FGE 2018-04-04 1.74 Crystal structure of human ZUFSP/ZUP1 in complex with ubiquitin
4MSM 2014-06-18 1.74 Crystal structure of Schizosaccharomyces pombe AMSH-like protease sst2 E286A mutant bound to ubiquitin
1WRD 2005-10-11 1.75 Crystal structure of Tom1 GAT domain in complex with ubiquitin
4K7U 2013-05-08 1.76 Crystal structure of Zn2.3-hUb (human ubiquitin) adduct from a solution 70 mM zinc acetate/1.3 mM hUb
6OI4 2019-05-15 1.76 RPN13 (19-132)-RPN2 (940-952) pY950-Ub complex
4K7W 2013-05-08 1.76 Crystal structure of Zn3-hUb(human ubiquitin) adduct from a solution 100 mM zinc acetate/1.3 mM hUb
4K7S 2013-05-08 1.76 Crystal structure of Zn2-hUb (human ubiquitin) adduct from a solution 35 mM zinc acetate/1.3 mM hUb
5XIS 2018-03-07 1.78 Crystal structure of RNF168 UDM1 in complex with Lys63-linked diubiquitin, form I
4HJK 2012-11-21 1.78 U7Ub7 Disulfide variant
3N32 2011-01-12 1.79 The crystal structure of human Ubiquitin adduct with Zeise's salt
5M93 2016-12-14 1.79 Crystal structure of SdeA-modified ubiquitin.
4ZQS 2016-04-20 1.8 New compact conformation of linear Ub2 structure
5ULF 2017-06-07 1.8 Crystal Structure of a UbcH5b~Ub conjugate
3K9O 2010-09-08 1.8 The crystal structure of E2-25K and UBB+1 complex
5XIU 2018-03-07 1.8 Crystal structure of RNF168 UDM2 in complex with Lys63-linked diubiquitin
5GO7 2016-11-02 1.8 Linear tri-ubiquitin
1UBQ 1987-04-16 1.8 STRUCTURE OF UBIQUITIN REFINED AT 1.8 ANGSTROMS RESOLUTION
6GLC 2018-06-13 1.8 Structure of phospho-Parkin bound to phospho-ubiquitin
3ONS 2011-02-23 1.8 Crystal structure of Human Ubiquitin in a new crystal form
1UBI 1994-05-31 1.8 SYNTHETIC STRUCTURAL AND BIOLOGICAL STUDIES OF THE UBIQUITIN SYSTEM. PART 1
2J7Q 2007-03-20 1.8 Crystal structure of the ubiquitin-specific protease encoded by murine cytomegalovirus tegument protein M48 in complex with a ubquitin-based suicide substrate
5XU8 2018-02-28 1.81 Crystal structure of human USP2 in complex with ubiquitin and 6-thioguanine
3EHV 2009-03-17 1.81 X-ray structure of human ubiquitin Zn(II) adduct
5X3M 2017-04-05 1.82 crystal structure of p-Ub-S65-NH2
5GOK 2016-11-02 1.84 K11/K63-branched tri-Ubiquitin
5TXK 2018-05-09 1.84 CRYSTAL STRUCTURE OF USP35 C450S IN COMPLEX WITH UBIQUITIN
3EFU 2008-12-09 1.84 X-ray structure of human ubiquitin-Hg(II) adduct
5L8H 2016-09-28 1.85 Structure of USP46-UbVME
3ALB 2010-08-25 1.85 Cyclic Lys48-linked tetraubiquitin
2HD5 2006-08-15 1.85 USP2 in complex with ubiquitin
1UZX 2004-03-30 1.85 A complex of the Vps23 UEV with ubiquitin
6B7O 2018-04-18 1.85 Crystal structure of Legionella effector sdeD (lpg2509) H67A in complex with ADP-ribosylated Ubiquitin
2QHO 2007-09-25 1.85 Crystal structure of the UBA domain from EDD ubiquitin ligase in complex with ubiquitin
5AF4 2015-03-25 1.85 Structure of Lys33-linked diUb
5WFI 2018-08-01 1.85 X-ray structure of MHV PLP2 (Cys1716Ser) catalytic mutant in complex with free ubiquitin
4Q5E 2014-07-02 1.87 Shigella Effector Kinase OspG bound to E2-Ub UbcH7-Ub Conjugate
5GVI 2017-09-13 1.87 Zebrafish USP30 in complex with Lys6-linked diubiquitin
6ISU 2019-02-06 1.87 Crystal structure of Lys27-linked di-ubiquitin in complex with its selective interacting protein UCHL3
3MHS 2010-04-21 1.89 Structure of the SAGA Ubp8/Sgf11/Sus1/Sgf73 DUB module bound to ubiquitin aldehyde
3WWQ 2015-05-13 1.9 Crystal structure of FAAP20 UBZ domain in complex with Lys63-linked diubiquitin
5CVM 2015-10-07 1.9 USP46~ubiquitin BEA covalent complex
4LDT 2013-08-14 1.9 The structure of h/ceOTUB1-ubiquitin aldehyde-UBCH5B~Ub
3B0A 2011-12-14 1.9 Crystal structure of the mouse HOIL1-L-NZF in complex with linear di-ubiquitin
4WZP 2015-01-14 1.9 Ser65 phosphorylated ubiquitin, major conformation
3H7P 2009-09-22 1.9 Crystal structure of K63-linked di-ubiquitin
3ZNZ 2013-06-26 1.9 Crystal structure of OTULIN OTU domain (C129A) in complex with Met1- di ubiquitin
2OOB 2007-02-06 1.9 crystal structure of the UBA domain from Cbl-b ubiquitin ligase in complex with ubiquitin
6GZS 2018-11-14 1.9 Structure of Chlamydia trachomatis effector protein ChlaDUB1 bound to ubiquitin
3TMP 2012-01-11 1.91 The catalytic domain of human deubiquitinase DUBA in complex with ubiquitin aldehyde
5D0M 2015-12-09 1.91 Structure of UbE2D2:RNF165:Ub complex
5GOH 2016-11-02 1.95 Lys33-linked di-ubiquitin
5ULH 2017-06-07 1.95 Structure of RNF165 in complex with a UbcH5b~Ub conjugate
2JF5 2008-02-05 1.95 crystal structure of Lys63-linked di-ubiquitin
4MSQ 2014-06-18 1.95 Crystal structure of Schizosaccharomyces pombe AMSH-like protease sst2 catalytic domain bound to ubiquitin
3VUW 2013-02-13 1.95 Crystal structure of A20 ZF7 in complex with linear ubiquitin, form I
6N6R 2019-07-17 1.95 Crystal structure of ABIN-1 UBAN in complex with two M1-linked di-ubiquitins
4PIG 2014-10-29 1.95 Crystal structure of the ubiquitin K11S mutant
3HM3 2009-08-25 1.96 The Structure and conformation of Lys-63 linked tetra-ubiquitin
5NL5 2017-04-26 1.96 Crystal structure of Zn1.7-E16V human ubiquitin (hUb) mutant adduct, from a solution 70 mM zinc acetate/1.3 mM E16V hUb
5KYE 2017-08-09 1.97 Crystal structure of USP7 catalytic domain [H294E] mutant in complex with ubiquitin
3VUY 2013-02-13 1.98 Crystal structure of A20 ZF7 in complex with linear tetraubiquitin
5GOG 2016-11-02 1.98 Lys29-linked di-ubiquitin
5JBY 2016-07-20 1.99 Lys27-linked triubiquitin
2G45 2006-04-04 1.99 Co-crystal structure of znf ubp domain from the deubiquitinating enzyme isopeptidase T (isot) in complex with ubiquitin
2GBK 2006-05-16 1.99 Crystal Structure of the 9-10 MoaD Insertion Mutant of Ubiquitin
4WLR 2015-03-04 2.0 Crystal Structure of mUCH37-hRPN13 CTD-hUb complex
5YDR 2018-02-21 2.0 Structure of DNMT1 RFTS domain in complex with ubiquitin
5WVO 2017-11-15 2.0 Crystal structure of DNMT1 RFTS domain in complex with K18/K23 mono-ubiquitylated histone H3
5V1Z 2017-05-03 2.0 Crystal structure of the RPN13 PRU-RPN2 (932-953)-ubiquitin complex
3PHW 2011-02-02 2.0 OTU Domain of Crimean Congo Hemorrhagic Fever Virus in complex with Ubiquitin
5LRW 2016-10-19 2.0 Structure of Cezanne/OTUD7B OTU domain bound to ubiquitin
4IG7 2013-05-29 2.0 Crystal structure of Trichinella spiralis UCH37 bound to Ubiquitin vinyl methyl ester
5JG6 2016-06-15 2.0 APC11-Ubv shows role of noncovalent RING-Ubiquitin interactions in processive multiubiquitination and Ubiquitin chain elongation by APC/C
1S1Q 2004-05-04 2.0 TSG101(UEV) domain in complex with Ubiquitin
4Q5H 2014-07-02 2.0 Shigella Effector Kinase OspG bound to AMPPNP and E2-Ub UbcH7-Ub Conjugate
2GBR 2006-05-16 2.0 Crystal Structure of the 35-36 MoaD Insertion Mutant of Ubiquitin
4V3K 2015-04-08 2.04 RNF38-UbcH5B-UB complex
5MN9 2017-01-25 2.05 Crystal structure of MINDY-1 tMIU in complex with K48-diUb
4FJV 2013-06-12 2.05 Crystal Structure of Human Otubain2 and Ubiquitin Complex
5HPS 2016-03-16 2.05 System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: WWP1 and UbV P1.1
3V6E 2012-12-19 2.1 Crystal Structure of USP2 and a mutant form of Ubiquitin
5JBV 2016-05-18 2.1 Lys27-linked triubiquitin
6AQR 2018-07-04 2.1 SAGA DUB module Ubp8(C146A)/Sgf11/Sus1/Sgf73 bound to monoubiquitin
4XKL 2015-11-11 2.1 Crystal structure of NDP52 ZF2 in complex with mono-ubiquitin
5BZ0 2016-06-15 2.1 Crystal structure of IBV papain-like protease PLpro C101S mutant in complex with ubiquitin
5DFL 2015-12-02 2.1 Crystal structure of Ube2K~Ubiquitin conjugate
6JB7 2019-03-20 2.1 Crystal structure of Ub-conjugated Ube2K C92K&K97A mutant (isopeptide linkage), 2.1 A resolution
2C7N 2006-02-15 2.1 Human Rabex-5 residues 1-74 in complex with Ubiquitin
4RF1 2014-10-22 2.15 Crystal structure of the Middle-East respiratory syndrome coronavirus papain-like protease in complex with ubiquitin (space group P63)
4LJP 2013-10-16 2.15 Structure of an active ligase (HOIP-H889A)/ubiquitin transfer complex
5MNJ 2017-05-31 2.16 Structure of MDM2-MDMX-UbcH5B-ubiquitin complex
3Q3F 2012-01-25 2.17 Engineering Domain-Swapped Binding Interfaces by Mutually Exclusive Folding: Insertion of Ubiquitin into position 103 of Barnase
4AUQ 2012-08-15 2.18 Structure of BIRC7-UbcH5b-Ub complex.
5ZQ3 2018-05-23 2.18 PDE-Ubiquitin
1SIF 2004-07-27 2.18 Crystal structure of a multiple hydrophobic core mutant of ubiquitin
3NOB 2010-08-11 2.19 Structure of K11-linked di-ubiquitin
3AXC 2012-01-25 2.19 Crystal structure of linear diubiquitin
5X3O 2017-04-12 2.19 Crystal structure of p-DiUb-S65-COOH
4II2 2013-02-13 2.2 Crystal structure of Ubiquitin activating enzyme 1 (Uba1) in complex with the Ub E2 Ubc4, ubiquitin, and ATP/Mg
5IFR 2016-05-11 2.2 Structure of the stable UBE2D3-UbDha conjugate
3A1Q 2009-07-21 2.2 Crystal structure of the mouse RAP80 UIMs in complex with Lys63-linked di-ubiquitin
5TR4 2017-11-01 2.2 Structure of Ubiquitin activating enzyme (Uba1) in complex with ubiquitin and TAK-243
2IBI 2006-10-24 2.2 Covalent Ubiquitin-USP2 Complex
2XEW 2010-07-14 2.2 Crystal structure of K11-linked diubiquitin
3A33 2009-11-24 2.2 UbcH5b~Ubiquitin Conjugate
4XOK 2015-10-14 2.2 Observing the overall rocking motion of a protein in a crystal.
2O6V 2007-02-13 2.2 Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH
3ZNI 2013-07-10 2.21 Structure of phosphoTyr363-Cbl-b - UbcH5B-Ub - ZAP-70 peptide complex
5AIU 2015-07-08 2.21 A complex of RNF4-RING domain, Ubc13-Ub (isopeptide crosslink)
5GO8 2016-11-02 2.21 Linear tetra-ubiquitin
4AP4 2012-07-25 2.21 Rnf4 - ubch5a - ubiquitin heterotrimeric complex
5ZQ4 2018-05-23 2.22 PDE-Ubi-ADPr
6QK9 2019-07-24 2.23 A dimeric ubiquitin formed by a single amino acid substitution
2W9N 2009-04-28 2.25 crystal structure of linear di-ubiquitin
1CMX 1999-07-27 2.25 STRUCTURAL BASIS FOR THE SPECIFICITY OF UBIQUITIN C-TERMINAL HYDROLASES
5XIT 2018-03-07 2.25 Crystal structure of RNF168 UDM1 in complex with Lys63-linked diubiquitin, form II
5XPK 2017-07-19 2.27 Crystal structure of ubiquitin-k6mimic
4R62 2015-09-02 2.28 Structure of Rad6~Ub
5VZW 2017-08-09 2.28 TRIM23 RING domain in complex with UbcH5-Ub
4Z9S 2015-07-29 2.3 Non-covalent assembly of monoubiquitin that mimics K11 poly-ubiquitin
5L6H 2017-06-14 2.3 Uba1 in complex with Ub-ABPA3 covalent adduct
4UEL 2015-03-04 2.3 UCH-L5 in complex with ubiquitin-propargyl bound to the RPN13 DEUBAD domain
3H7S 2009-09-22 2.3 Crystal structures of K63-linked di- and tri-ubiquitin reveal a highly extended chain architecture
3WXF 2015-02-11 2.3 Crystal structure of CYLD USP domain (C596S E674Q) in complex with Met1-linked diubiquitin
3PRM 2011-01-26 2.3 Structural analysis of a viral OTU domain protease from the Crimean-Congo Hemorrhagic Fever virus in complex with human ubiquitin
2WDT 2009-12-29 2.3 Crystal structure of Plasmodium falciparum UCHL3 in complex with the suicide inhibitor UbVME
1AAR 1993-10-31 2.3 STRUCTURE OF A DIUBIQUITIN CONJUGATE AND A MODEL FOR INTERACTION WITH UBIQUITIN CONJUGATING ENZYME (E2)
1NBF 2003-01-07 2.3 Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde
4NQL 2014-10-08 2.3 The crystal structure of the DUB domain of AMSH orthologue, Sst2 from S. pombe, in complex with lysine 63-linked diubiquitin
4ZFT 2015-10-14 2.3 Catalytic domain of Sst2 F403W mutant bound to ubiquitin
3ZNH 2013-02-27 2.3 Crimean Congo Hemorrhagic Fever Virus OTU domain in complex with ubiquitin-propargyl.
4S22 2015-04-08 2.3 Crystal structure of K29 linked di-Ubiquitin
5HPL 2016-03-16 2.31 System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: Rsp5 and UbV R5.4
3C0R 2008-02-19 2.32 Structure of Ovarian Tumor (OTU) domain in complex with Ubiquitin
5OHK 2017-09-20 2.34 Crystal structure of USP30 in covalent complex with ubiquitin propargylamide (high resolution)
6DGF 2019-02-13 2.34 Ubiquitin Variant bound to USP2
5FER 2016-05-18 2.34 Complex of TRIM25 RING with UbcH5-Ub
3OFI 2010-09-08 2.35 Crystal structure of human insulin-degrading enzyme in complex with ubiquitin
4BOS 2013-07-24 2.35 Structure of OTUD2 OTU domain in complex with Ubiquitin K11-linked peptide
4DHJ 2012-02-22 2.35 The structure of a ceOTUB1 ubiquitin aldehyde UBC13~Ub complex
3UGB 2012-05-16 2.35 UbcH5c~Ubiquitin Conjugate
6ASR 2018-06-20 2.36 REV1 UBM2 domain complex with ubiquitin
5XDP 2017-04-19 2.38 K11/48-branched teraubiquitin
5ULK 2017-06-07 2.38 Crystal Structure of RNF165 in complex with a UbcH5b~Ub conjugate
3AUL 2011-09-07 2.39 Crystal structure of wild-type Lys48-linked diubiquitin in an open conformation
4KSK 2013-06-05 2.4 Gumby/Fam105B in complex with ubiquitin
1TBE 1994-01-31 2.4 STRUCTURE OF TETRAUBIQUITIN SHOWS HOW MULTIUBIQUITIN CHAINS CAN BE FORMED
5EYA 2016-08-17 2.4 TRIM25 RING domain in complex with Ubc13-Ub conjugate
3VDZ 2012-11-28 2.4 Tailoring Encodable Lanthanide-Binding Tags as MRI Contrast Agents: xq-dSE3-Ubiquitin at 2.4 Angstroms
3IFW 2010-06-16 2.4 Crystal structure of the S18Y variant of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester.
4NNJ 2014-05-07 2.4 Crystal structure of Uba1 in complex with ubiquitin-AMP and thioesterified ubiquitin
6A43 2018-10-24 2.4 R1EN(5-225)-ubiquitin fusion
3VHT 2012-10-10 2.4 Crystal structure of GFP-Wrnip1 UBZ domain fusion protein in complex with ubiquitin
2WX0 2009-11-24 2.4 TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked di-ubiquitin, P21
2C7M 2006-02-15 2.4 Human Rabex-5 residues 1-74 in complex with Ubiquitin
6A44 2018-10-24 2.4 R1EN(5-227)-ubiquitin fusion
3U30 2012-01-18 2.43 Crystal structure of a linear-specific Ubiquitin fab bound to linear ubiquitin
5HPK 2016-03-16 2.43 System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: NEDD4L and UbV NL.1
6IF1 2018-11-21 2.47 Crystal structure of Ube2K and K48-linked di-ubiquitin complex
2FIF 2006-02-07 2.49 Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin
5BNB 2016-02-17 2.49 Crystal structure of a Ube2S-ubiquitin conjugate
5ZQ5 2018-05-23 2.49 SidE-Ubi
4I6L 2013-01-16 2.49 Crystal structure of OTUB1 in complex with ubiquitin variant
3OLM 2011-03-23 2.49 Structure and Function of a Ubiquitin Binding Site within the Catalytic Domain of a HECT Ubiquitin Ligase
3RUL 2012-06-06 2.5 New strategy to analyze structures of glycopeptide-target complexes
3PT2 2011-01-19 2.5 Structure of a viral OTU domain protease bound to Ubiquitin
5IBK 2016-03-30 2.5 Skp1-F-box in complex with a ubiquitin variant
3WXE 2015-02-11 2.5 Crystal structure of CYLD USP domain (C596S) in complex with Met1-linked diubiquitin
5OHL 2017-10-04 2.5 K6-specific affimer bound to K6 diUb
6FX4 2018-07-11 2.5 Disulfide between E3 HECT ligase Smurf2 and Ubiquitin G76C
2GMI 2006-09-19 2.5 Mms2/Ubc13~Ubiquitin
5J26 2016-12-14 2.5 Crystal structure of a 53BP1 Tudor domain in complex with a ubiquitin variant
3OJ3 2010-12-08 2.5 Crystal structure of the A20 ZnF4 and ubiquitin complex
5U4P 2017-09-06 2.5 Protein-protein complex between 26S proteasome regulatory subunit RPN8, RPN11, and Ubiquitin S31
5YDK 2018-03-07 2.51 Crystal structure of RNF168 UDM1 in complex with Lys63-linked diubiquitin, tetrameric form
4BBN 2013-05-01 2.51 NEDD4 HECT-Ub:Ub complex
3I3T 2009-07-21 2.59 Crystal structure of covalent ubiquitin-USP21 complex
5H07 2017-03-08 2.59 TNIP2-Ub complex, C2 form
2OJR 2007-06-12 2.6 Structure of ubiquitin solved by SAD using the Lanthanide-Binding Tag
3LDZ 2010-03-02 2.6 Crystal structure of human STAM1 VHS domain in complex with ubiquitin
6O82 2019-06-19 2.6 S. pombe ubiquitin E1 complex with a ubiquitin-AMP mimic
4HCN 2012-11-21 2.6 Crystal structure of Burkholderia pseudomallei effector protein CHBP in complex with ubiquitin
6A6I 2019-02-13 2.6 Crystal structure of the winged-helix domain of Cockayne syndrome group B protein in complex with ubiquitin
5N38 2017-04-19 2.6 S65DParkin and pUB complex
5TUT 2017-11-08 2.6 UbcH5a-Ub isopeptide conjugate
3N3K 2010-06-23 2.6 The catalytic domain of USP8 in complex with a USP8 specific inhibitor
1WR6 2005-06-28 2.6 Crystal structure of GGA3 GAT domain in complex with ubiquitin
3DVG 2008-09-30 2.6 Crystal structure of K63-specific fab Apu.3A8 bound to K63-linked di-ubiquitin
6BYH 2018-07-18 2.61 Ubiquitin Variant (UbV.Fl11.1) bound to a human Skp1-Fbl11 fragment complex.
4MDK 2013-12-11 2.61 Cdc34-ubiquitin-CC0651 complex
5CAW 2015-07-22 2.62 Structure of Pediculus humanus Parkin bound to phospho-ubiquitin
5CRA 2015-11-25 2.64 Structure of the SdeA DUB Domain
5D0K 2015-12-09 2.65 Structure of UbE2D2:RNF165:Ub complex
5JQS 2016-06-22 2.65 Crystal structure of deubiquitinase MINDY-1 in complex with Ubiquitin
6BVA 2018-07-18 2.66 Ubiquitin Variant (UbV.Fl10.1) bound to a human Skp1-Fbl10 fragment complex.
5L6J 2017-06-14 2.68 Uba1 in complex with Ub-MLN7243 covalent adduct
2XBB 2011-03-23 2.68 Nedd4 HECT:Ub complex
5N2W 2017-04-19 2.68 WT-Parkin and pUB complex
5B83 2016-09-07 2.69 Crystal structure of Optineurin UBAN in complex with linear ubiquitin
3CMM 2008-08-05 2.7 Crystal Structure of the Uba1-Ubiquitin Complex
2Y5B 2012-01-25 2.7 Structure of USP21 in complex with linear diubiquitin-aldehyde
4BVU 2014-01-29 2.7 Structure of Shigella effector OspG in complex with host UbcH5c- Ubiquitin conjugate
2HTH 2006-10-24 2.7 Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain
1F9J 2001-02-07 2.7 STRUCTURE OF A NEW CRYSTAL FORM OF TETRAUBIQUITIN
6JB6 2019-03-20 2.7 Crystal structure of Ub-conjugated Ube2K C92K&K97A mutant (isopeptide linkage), 2.7 A resolution
3DVN 2008-09-30 2.7 Crystal structure of K63-specific fab Apu2.16 bound to K63-linked di-ubiquitin
3JSV 2009-10-27 2.7 Crystal structure of mouse NEMO CoZi in complex with Lys63-linked di-ubiquitin
3PTF 2011-05-11 2.7 X-ray structure of the non-covalent complex between UbcH5A and Ubiquitin
3MTN 2010-06-09 2.7 Usp21 in complex with a ubiquitin-based, USP21-specific inhibitor
3O65 2010-11-24 2.7 Crystal structure of a Josephin-ubiquitin complex: Evolutionary restraints on ataxin-3 deubiquitinating activity
4MM3 2014-07-02 2.75 Crystal structure of SARS-CoV papain-like protease PLpro in complex with ubiquitin aldehyde
5L6I 2017-06-14 2.76 Uba1 in complex with Ub-MLN4924 covalent adduct
5L8W 2016-09-28 2.79 Structure of USP12-UB-PRG/UAF1
3K9P 2010-09-08 2.8 The crystal structure of E2-25K and ubiquitin complex
3L0W 2010-03-23 2.8 Structure of split monoubiquitinated PCNA with ubiquitin in position two
3KVF 2010-06-16 2.8 Crystal structure of the I93M mutant of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester
5LRV 2016-10-19 2.8 Structure of Cezanne/OTUD7B OTU domain bound to Lys11-linked diubiquitin
4RF0 2014-10-22 2.8 Crystal structure of the Middle-East respiratory syndrome coronavirus papain-like protease in complex with ubiquitin (space group P6522)
5OHP 2017-09-20 2.8 Crystal structure of USP30 (C77A) in complex with Lys6-linked diubiquitin
2FID 2006-02-07 2.8 Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin
1YD8 2005-02-22 2.8 COMPLEX OF HUMAN GGA3 GAT DOMAIN AND UBIQUITIN
3L10 2010-03-23 2.8 Structure of split monoubiquitinated PCNA with ubiquitin in position one
5OHV 2017-10-04 2.8 K33-specific affimer bound to K33 diUb
3IHP 2009-12-29 2.8 Covalent Ubiquitin-Usp5 Complex
3VFK 2013-01-09 2.8 The structure of monodechloro-teicoplanin in complex with its ligand, using ubiquitin as a ligand carrier
4U4R 2014-10-22 2.8 Crystal structure of Lactimidomycin bound to the yeast 80S ribosome
3KW5 2010-06-16 2.83 Crystal structure of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester
4KSL 2013-06-05 2.83 Gumby/Fam105B in complex with linear di-ubiquitin
5HPT 2016-03-16 2.84 System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: WWP1, Ubv P2.3 and UBCH7
5ZQ7 2018-05-23 2.85 SidE-Ubi-NAD
5LRX 2016-10-19 2.85 Structure of A20 OTU domain bound to ubiquitin
4HXD 2013-02-13 2.85 Diversity of ubiquitin and ISG15 specificity amongst nairoviruses viral ovarian tumor domain proteases
5E6J 2016-05-18 2.85 Structure of SARS PLpro bound to a Lys48-linked di-ubiquitin activity based probe
2ZVO 2009-03-24 2.9 NEMO CoZi domain in complex with diubiquitin in C2 space group
6QZP 2019-04-24 2.9 High-resolution cryo-EM structure of the human 80S ribosome
5JP3 2016-07-27 2.9 Structure of Xanthomonas campestris effector protein XopD bound to ubiquitin
4JQW 2014-03-26 2.9 Crystal Structure of a Complex of NOD1 CARD and Ubiquitin
3TBL 2012-05-23 2.9 Structure of Mono-ubiquitinated PCNA: Implications for DNA Polymerase Switching and Okazaki Fragment Maturation
4II3 2013-02-13 2.9 Crystal structure of S. pombe Ubiquitin activating enzyme 1 (Uba1) in complex with ubiquitin and ATP/Mg
6EK0 2018-01-24 2.9 High-resolution cryo-EM structure of the human 80S ribosome
6CP2 2018-08-01 2.9 SidC in complex with UbcH7~Ub
3ZLZ 2013-04-10 2.9 Lys6-linked tri-ubiquitin
4U3U 2014-10-22 2.9 Crystal structure of Cycloheximide bound to the yeast 80S ribosome
4XOL 2015-10-14 2.91 Observing the overall rocking motion of a protein in a crystal - Cubic Ubiquitin crystals.
6FYH 2018-07-11 2.91 Disulfide between ubiquitin G76C and the E3 HECT ligase Huwe1
5OE7 2017-09-27 2.95 Structure of OTULIN bound to the Met1-linked diubiquitin activity probe
6MSB 2018-12-05 3.0 Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome
4U4U 2014-10-22 3.0 Crystal structure of Lycorine bound to the yeast 80S ribosome
4U3M 2014-10-22 3.0 Crystal structure of Anisomycin bound to the yeast 80S ribosome
2WX1 2009-11-24 3.0 TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked tri-ubiquitin, P212121
5C7J 2016-03-16 3.0 CRYSTAL STRUCTURE OF NEDD4 WITH A UB VARIANT
2XK5 2010-08-25 3.0 Crystal structure of K6-linked diubiquitin
5TBW 2017-07-26 3.0 Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome
5WQ4 2017-12-06 3.0 Crystal structure of OPTN and linear diubiquitin complex
4U4Q 2014-10-22 3.0 Crystal structure of Homoharringtonine bound to the yeast 80S ribosome
3PHD 2011-02-23 3.0 Crystal structure of human HDAC6 in complex with ubiquitin
3EEC 2009-03-10 3.0 X-ray structure of human ubiquitin Cd(II) adduct
4XKH 2016-02-17 3.0 CRYSTAL STRUCTURE OF THE AIRAPL TANDEM UIMS IN COMPLEX WITH A LYS48-LINKED TRI-UBIQUITIN
3H1U 2009-05-05 3.0 Structure of ubiquitin in complex with Cd ions
4U52 2014-10-22 3.0 Crystal structure of Nagilactone C bound to the yeast 80S ribosome
3N30 2011-01-12 3.0 Crystal Structure of cubic Zn3-hUb (human ubiquitin) adduct
4V88 2014-07-09 3.0 The structure of the eukaryotic ribosome at 3.0 A resolution.
2ZVN 2009-03-24 3.0 NEMO CoZi domain incomplex with diubiquitin in P212121 space group
6N5M 2019-07-17 3.01 Crystal structure of ABIN-1 UBAN in complex with one M1-linked di-ubiquitin
5ZQ6 2018-05-23 3.01 SidE-Ubi-ADPr
6FYY 2018-12-05 3.02 Structure of a partial yeast 48S preinitiation complex with eIF5 N-terminal domain (model C2)
6HEK 2019-03-27 3.03 Structure of human USP28 bound to Ubiquitin-PA
4BOZ 2013-07-17 3.03 Structure of OTUD2 OTU domain in complex with K11-linked di ubiquitin
4S1Z 2015-04-08 3.03 Crystal structure of TRABID NZF1 in complex with K29 linked di-Ubiquitin
5C7M 2016-03-16 3.03 CRYSTAL STRUCTURE OF E3 LIGASE ITCH WITH A UB VARIANT
3WXG 2015-02-11 3.1 Crystal structure of CYLD USP domain (C596A) in complex with Lys63-linked diubiquitin
5T62 2017-02-08 3.1 Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis: 60S-Nmd3-Tif6-Lsg1 Complex
5DGV 2016-12-14 3.1 Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog
4U6F 2014-10-22 3.1 Crystal structure of T-2 toxin bound to the yeast 80S ribosome
5YIK 2018-05-30 3.1 Structure of a Legionella effector with its substrate
6Q8Y 2019-03-13 3.1 Cryo-EM structure of the mRNA translating and degrading yeast 80S ribosome-Xrn1 nuclease complex
6QIK 2019-06-26 3.1 Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
5ON6 2018-02-28 3.1 Crystal structure of haemanthamine bound to the 80S ribosome
5FCJ 2016-05-11 3.1 Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome
4LCD 2013-08-14 3.1 Structure of an Rsp5xUbxSna3 complex: Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3
5I4L 2016-06-22 3.1 Crystal structure of Amicoumacin A bound to the yeast 80S ribosome
6EQI 2017-11-08 3.1 Structure of PINK1 bound to ubiquitin
6OLE 2019-06-19 3.1 Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs
6HHQ 2019-02-20 3.1 Crystal structure of compound C45 bound to the yeast 80S ribosome
6OM0 2019-06-19 3.1 Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE tRNAs
4U4Z 2014-10-22 3.1 Crystal structure of Phyllanthoside bound to the yeast 80S ribosome
3JW0 2010-01-12 3.1 E2~Ubiquitin-HECT
4U4N 2014-10-22 3.1 Crystal structure of Edeine bound to the yeast 80S ribosome
4DHZ 2012-02-22 3.11 The structure of h/ceOTUB1-ubiquitin aldehyde-UBC13~Ub
5LN1 2016-10-19 3.14 STRUCTURE OF UBIQUITYLATED-RPN10 FROM YEAST;
5O44 2017-11-08 3.14 Crystal structure of unbranched mixed tri-Ubiquitin chain containing K48 and K63 linkages.
6DC6 2018-10-10 3.14 Crystal structure of human ubiquitin activating enzyme E1 (Uba1) in complex with ubiquitin
5DAT 2016-08-31 3.15 Complex of yeast 80S ribosome with hypusine-containing eIF5A
6O83 2019-06-19 3.15 S. pombe ubiquitin E1~ubiquitin-AMP tetrahedral intermediate mimic
4WUR 2014-11-26 3.16 The crystal structure of the MERS-CoV papain-like protease (C111S) with human ubiquitin
5YIJ 2018-05-30 3.18 Structure of a Legionella effector with substrates
5ZBU 2019-02-27 3.2 Crystal Structure of PA-TM-RING E3 ligase RNF13 RING domain in complex with E2~Ub
4U50 2014-10-22 3.2 Crystal structure of Verrucarin bound to the yeast 80S ribosome
4U4Y 2014-10-22 3.2 Crystal structure of Pactamycin bound to the yeast 80S ribosome
4U55 2014-10-22 3.2 Crystal structure of Cryptopleurine bound to the yeast 80S ribosome
4U3N 2014-10-22 3.2 Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome
4U51 2014-10-22 3.2 Crystal structure of Narciclasine bound to the yeast 80S ribosome
6MSD 2018-12-05 3.2 Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome
5UDH 2017-06-14 3.24 HHARI/ARIH1-UBCH7~Ubiquitin
5LYB 2016-11-23 3.25 Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCPmn
5DC3 2016-06-01 3.25 Complex of yeast 80S ribosome with non-modified eIF5A
6C16 2018-07-18 3.27 Ubiquitin variant (UbV.Fbl10.1) bound to a human Skp1-Fbl11 fragment complex.
6S47 2019-07-24 3.28 Saccharomyces cerevisiae 80S ribosome bound with ABCF protein New1
5NDV 2017-12-13 3.3 Crystal structure of Paromomycin bound to the yeast 80S ribosome
6QKL 2019-03-20 3.3 Mechanism of eIF6 release from the nascent 60S ribosomal subunit
4DDG 2012-02-22 3.3 Crystal structure of human OTUB1/UbcH5b~Ub/Ub
5TGA 2016-11-23 3.3 Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro
4U53 2014-10-22 3.3 Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome
5M1J 2017-01-18 3.3 Nonstop ribosomal complex bound with Dom34 and Hbs1
6RI5 2019-06-26 3.3 Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
3JVZ 2010-01-12 3.3 E2~Ubiquitin-HECT
5DGF 2016-12-14 3.3 Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog
6MSE 2018-11-21 3.3 Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome
5AN9 2015-10-21 3.3 Mechanism of eIF6 release from the nascent 60S ribosomal subunit
5JTV 2016-10-12 3.31 USP7CD-UBL45 in complex with Ubiquitin
5JTJ 2016-08-10 3.32 USP7CD-CTP in complex with Ubiquitin
2DX5 2006-10-10 3.35 The complex structure between the mouse EAP45-GLUE domain and ubiquitin
5CVN 2015-10-07 3.36 WDR48 (2-580):USP46~ubiquitin ternary complex
3J7Q 2014-09-03 3.4 Structure of the idle mammalian ribosome-Sec61 complex
6R87 2019-06-26 3.4 Yeast Vms1 (Q295L)-60S ribosomal subunit complex (pre-state without Arb1)
5AF6 2015-03-25 3.4 Structure of Lys33-linked diUb bound to Trabid NZF1
6R86 2019-07-31 3.4 Yeast Vms1-60S ribosomal subunit complex (post-state)
6OLG 2019-06-19 3.4 Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA)
6QT0 2019-06-26 3.4 Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
5AIT 2015-07-08 3.4 A complex of of RNF4-RING domain, UbeV2, Ubc13-Ub (isopeptide crosslink)
3J7O 2014-09-03 3.4 Structure of the mammalian 60S ribosomal subunit
5OBM 2017-12-13 3.4 Crystal structure of Gentamicin bound to the yeast 80S ribosome
4P4H 2014-07-30 3.4 Caught-in-action signaling complex of RIG-I 2CARD domain and MAVS CARD domain
5FCI 2016-05-11 3.4 Structure of the vacant uL3 W255C mutant 80S yeast ribosome
6HD7 2018-12-19 3.4 Cryo-EM structure of the ribosome-NatA complex
3OJ4 2010-12-08 3.4 Crystal structure of the A20 ZnF4, ubiquitin and UbcH5A complex
5APO 2015-12-16 3.41 Structure of the yeast 60S ribosomal subunit in complex with Arx1, Alb1 and C-terminally tagged Rei1
5VNZ 2017-12-06 3.41 Structure of a TRAF6-Ubc13~Ub complex
5DGE 2017-01-25 3.45 Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome
4U56 2014-10-22 3.45 Crystal structure of Blasticidin S bound to the yeast 80S ribosome
3JAM 2015-08-12 3.46 CryoEM structure of 40S-eIF1A-eIF1 complex from yeast
5EDV 2016-01-20 3.48 Structure of the HOIP-RBR/UbcH5B~ubiquitin transfer complex
5H7S 2017-11-29 3.49 Structural basis of the flanking zinc-finger motifs crucial for the E3 ligase activity of the LNX1 RING domain
5JUP 2016-10-05 3.5 Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure II (mid-rotated 40S subunit)
6MSG 2018-11-21 3.5 Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome
6FYX 2018-12-05 3.5 Structure of a partial yeast 48S preinitiation complex with eIF5 N-terminal domain (model C1)
5AJ0 2015-05-20 3.5 Cryo electron microscopy of actively translating human polysomes (POST state).
6OLI 2019-06-19 3.5 Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule (USO1-RNC)
5KHY 2016-09-14 3.5 Crystal structure of oxime-linked K6 diubiquitin
5TTE 2017-08-23 3.5 Crystal Structure of an RBR E3 ubiquitin ligase in complex with an E2-Ub thioester intermediate mimic
6N8M 2019-03-13 3.5 Cryo-EM structure of pre-Lsg1 (PL) pre-60S ribosomal subunit
6G5I 2018-06-06 3.5 Cryo-EM structure of a late human pre-40S ribosomal subunit - State R
6QTZ 2019-06-26 3.5 Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
6O96 2019-04-24 3.5 Dot1L bound to the H2BK120 Ubiquitinated nucleosome
5TGM 2017-01-18 3.5 Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro
3J7P 2014-09-03 3.5 Structure of the 80S mammalian ribosome bound to eEF2
5MEI 2017-06-28 3.5 Crystal structure of Agelastatin A bound to the 80S ribosome
2AYO 2005-10-18 3.5 Structure of USP14 bound to ubquitin aldehyde
6N8O 2019-03-13 3.5 Cryo-EM structure of Rpl10-inserted (RI) pre-60S ribosomal subunit
6H4H 2019-03-27 3.5 Usp28 catalytic domain variant E593D in complex with UbPA
4V8P 2014-07-09 3.52 T.thermophila 60S ribosomal subunit in complex with initiation factor 6.
6NQA 2019-02-20 3.54 Active state Dot1L bound to the H2B-Ubiquitinated nucleosome, 1-to-1 complex
5T2C 2017-01-25 3.6 CryoEM structure of the human ribosome at 3.6 Angstrom resolution
6G18 2018-06-06 3.6 Cryo-EM structure of a late human pre-40S ribosomal subunit - State C
5LKS 2017-04-26 3.6 Structure-function insights reveal the human ribosome as a cancer target for antibiotics
6EML 2017-11-29 3.6 Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae
6R84 2019-06-26 3.6 Yeast Vms1 (Q295L)-60S ribosomal subunit complex (pre-state with Arb1)
5OHN 2017-09-20 3.6 Crystal structure of USP30 in covalent complex with ubiquitin propargylamide (low resolution)
5IT7 2016-05-18 3.6 Structure of the Kluyveromyces lactis 80S ribosome in complex with the cricket paralysis virus IRES and eEF2
6G5H 2018-06-06 3.6 Cryo-EM structure of a late human pre-40S ribosomal subunit - Mature
4U4O 2014-10-22 3.6 Crystal structure of Geneticin bound to the yeast 80S ribosome
4JIO 2013-06-19 3.6 Bro1 V domain and ubiquitin
4UG0 2015-06-10 3.6 STRUCTURE OF THE HUMAN 80S RIBOSOME
4UF6 2015-03-04 3.69 UCH-L5 in complex with ubiquitin-propargyl bound to an activating fragment of INO80G
5NDW 2017-12-13 3.7 Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome
4NQK 2014-03-05 3.7 Structure of an Ubiquitin complex
5NDG 2017-12-13 3.7 Crystal structure of geneticin (G418) bound to the yeast 80S ribosome
6OM7 2019-06-19 3.7 Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs
3J80 2014-11-05 3.75 CryoEM structure of 40S-eIF1-eIF1A preinitiation complex
6DJW 2018-07-04 3.8 Crystal Structure of pParkin (REP and RING2 deleted)-pUb-UbcH7 complex
4DDI 2012-02-22 3.8 Crystal structure of human OTUB1/UbcH5b~Ub/Ub
5MC6 2017-01-18 3.8 Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae
6RBE 2019-06-26 3.8 State 2 of yeast Tsr1-TAP Rps20-Deltaloop pre-40S particles
6N8N 2019-03-13 3.8 Cryo-EM structure of Lsg1-engaged (LE) pre-60S ribosomal subunit
5OHM 2017-10-04 3.8 K33-specific affimer bound to K33 diUb
5IT9 2016-05-18 3.8 Structure of the yeast Kluyveromyces lactis small ribosomal subunit in complex with the cricket paralysis virus IRES.
4ZUX 2016-02-24 3.82 SAGA DUB module Ubp8/Sgf11/Sus1/Sgf73 bound to ubiqitinated nucleosome
5CVO 2015-10-07 3.88 WDR48:USP46~ubiquitin ternary complex
5GAK 2016-02-24 3.88 Yeast 60S ribosomal subunit with A-site tRNA, P-site tRNA and eIF-5A
6IP8 2019-05-29 3.9 Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv)
6OA9 2019-07-03 3.9 Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ATP
3J7R 2014-09-03 3.9 Structure of the translating mammalian ribosome-Sec61 complex
6GQB 2018-07-11 3.9 Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GDP+AlF4/sordarin)
6IP5 2019-05-29 3.9 Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii)
5A2Q 2015-07-15 3.9 Structure of the HCV IRES bound to the human ribosome
6OLF 2019-06-19 3.9 Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs
6OLZ 2019-06-19 3.9 Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA
5VO0 2017-12-06 3.9 Structure of a TRAF6-Ubc13~Ub complex
5FLX 2015-12-23 3.9 Mammalian 40S HCV-IRES complex
5APN 2015-12-16 3.91 Structure of the yeast 60S ribosomal subunit in complex with Arx1, Alb1 and N-terminally tagged Rei1
5JUU 2016-10-05 4.0 Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure V (least rotated 40S subunit)
5JUO 2016-10-05 4.0 Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure I (fully rotated 40S subunit)
6GQV 2018-07-11 4.0 Cryo-EM recosntruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP)
5JUT 2016-10-05 4.0 Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure IV (almost non-rotated 40S subunit)
3J81 2014-11-05 4.0 CryoEM structure of a partial yeast 48S preinitiation complex
6G51 2018-06-06 4.1 Cryo-EM structure of a late human pre-40S ribosomal subunit - State D
6J99 2019-02-27 4.1 Cryo-EM structure of human DOT1L in complex with an H2B-monoubiquitinated nucleosome
6OAA 2019-07-03 4.1 Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ADP-BeFx, state 1
5ANB 2015-10-21 4.1 Mechanism of eIF6 release from the nascent 60S ribosomal subunit
6EF3 2018-10-17 4.17 Yeast 26S proteasome bound to ubiquitinated substrate (4D motor state)
5T6R 2017-02-08 4.2 Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis: 60S-Nmd3 Complex
5JUS 2016-10-05 4.2 Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure III (mid-rotated 40S subunit)
5ANC 2015-10-21 4.2 Mechanism of eIF6 release from the nascent 60S ribosomal subunit
4V8Y 2014-07-09 4.3 Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex
5GJQ 2016-08-17 4.35 Structure of the human 26S proteasome bound to USP14-UbAl
6GQ1 2018-07-11 4.4 Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP/sordarin)
6FTX 2018-08-08 4.5 Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome
6IP6 2019-05-29 4.5 Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii)
6G53 2018-06-06 4.5 Cryo-EM structure of a late human pre-40S ribosomal subunit - State E
5KGF 2016-07-27 4.54 Structural model of 53BP1 bound to a ubiquitylated and methylated nucleosome, at 4.5 A resolution
6DJX 2018-07-04 4.8 Crystal Structure of pParkin-pUb-UbcH7 complex
3JAP 2015-08-12 4.9 Structure of a partial yeast 48S preinitiation complex in closed conformation
4V6X 2014-07-09 5.0 Structure of the human 80S ribosome
6GSM 2019-07-31 5.15 Structure of a partial yeast 48S preinitiation complex in open conformation
6I7O 2019-01-16 5.3 The structure of a di-ribosome (disome) as a unit for RQC and NGD quality control pathways recognition.
4V8M 2014-07-09 5.57 High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome
6GSN 2019-06-26 5.75 Structure of a partial yeast 48S preinitiation complex in closed conformation
3JAQ 2015-08-12 6.0 Structure of a partial yeast 48S preinitiation complex in open conformation
4V6W 2014-07-09 6.0 Structure of the D. melanogaster 80S ribosome
3J6Y 2014-06-11 6.1 S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 2 degree rotation (Class I)
3J6X 2014-06-11 6.1 S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 5 degree rotation (Class II)
3J77 2014-08-06 6.2 Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class II - rotated ribosome with 1 tRNA)
3J78 2014-08-06 6.3 Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class I - non-rotated ribosome with 2 tRNAs)
6FEC 2018-03-14 6.3 Human cap-dependent 48S pre-initiation complex
5L9T 2016-10-26 6.4 Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for polyubiquitination where UBE2S, APC2, and APC11 are modeled into low resolution density
5L9U 2016-09-14 6.4 Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination
4ADX 2012-02-08 6.6 The Cryo-EM Structure of the Archaeal 50S Ribosomal Subunit in Complex with Initiation Factor 6
4V8Z 2014-07-09 6.6 Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex
6JMA 2019-05-15 6.8 cryo-EM structure of DOT1L bound to H2B ubiquitinated nucleosome
4V8T 2014-07-09 8.1 Cryo-EM Structure of the 60S Ribosomal Subunit in Complex with Arx1 and Rei1
4WHV 2015-09-30 8.3 E3 ubiquitin-protein ligase RNF8 in complex with Ubiquitin-conjugating enzyme E2 N and Polyubiquitin-B
5WYJ 2017-03-29 8.7 Cryo-EM structure of the 90S small subunit pre-ribosome (Dhr1-depleted, Enp1-TAP, state 1)
4V6I 2014-07-09 8.8 Localization of the small subunit ribosomal proteins into a 6.1 A cryo-EM map of Saccharomyces cerevisiae translating 80S ribosome
5A5B 2015-07-22 9.5 Structure of the 26S proteasome-Ubp6 complex

Relevant UniProtKB Entries

Percent Identity Matching Chains Protein Accession Entry Name
97.5 Polyubiquitin-C P31753 RS27A_ASPOF
100.0 Polyubiquitin-C P84589 UBIQ_LUMTE
95.7 Polyubiquitin-C P59272 RS27A_DAUCA
95.8 Polyubiquitin-C P0C8R3 RS27B_SCHPO
95.8 Polyubiquitin-C P0C016 RS27A_SCHPO
95.8 Polyubiquitin-C P27923 RS27A_MAIZE
95.8 Polyubiquitin-C P47905 RS27A_LUPAL
95.8 Polyubiquitin-C P0CG87 RS272_HORVU
95.8 Polyubiquitin-C P0CG86 RS271_HORVU
95.8 Polyubiquitin-C P59233 R27AC_ARATH
95.8 Polyubiquitin-C P51431 R27AB_ORYSJ
95.8 Polyubiquitin-C P59232 R27AB_ARATH
95.8 Polyubiquitin-C Q9ARZ9 R27AA_ORYSJ
95.9 Polyubiquitin-C P14797 RS27A_DICDI
96.0 Polyubiquitin-C P14799 RS27A_NEUCR
94.7 Polyubiquitin-C P69200 RL40_LEITA
93.4 Polyubiquitin-C P23324 UBIQP_EUPEU
96.0 Polyubiquitin-C P05759 RS31_YEAST
96.0 Polyubiquitin-C P69061 RS27A_KLULA
94.7 Polyubiquitin-C P21899 RL40_TRYBB
93.4 Polyubiquitin-C Q9FHQ6 UBQ9_ARATH
94.7 Polyubiquitin-C Q3E7K8 UBQ12_ARATH
96.1 Polyubiquitin-C P0CG70 UBI4P_NEUCR
96.1 Polyubiquitin-C P14795 RL40_TRYCR
96.1 Polyubiquitin-C P0C224 RL40_NEUCR
96.1 Polyubiquitin-C P49633 RL40_ACACA
96.1 Polyubiquitin-C P0CH27 RL402_TRYCR
94.7 Polyubiquitin-C P22589 UBIQP_PHYIN
94.7 Polyubiquitin-C P42739 UBIQP_ACEPE
94.7 Polyubiquitin-C P0C032 RUB3_ORYSJ
96.1 Polyubiquitin-C P0CH32 UBQ4_ARATH
96.1 Polyubiquitin-C Q58G87 UBQ3_ORYSJ
96.1 Polyubiquitin-C Q1EC66 UBQ3_ARATH
96.1 Polyubiquitin-C Q3E7T8 UBQ14_ARATH
96.1 Polyubiquitin-C P0CH33 UBQ11_ARATH
96.1 Polyubiquitin-C Q8H159 UBQ10_ARATH
96.1 Polyubiquitin-C P69326 UBIQ_WHEAT
96.1 Polyubiquitin-C P69317 UBIQ_LUPPO
96.1 Polyubiquitin-C P69313 UBIQ_HELAN
96.1 Polyubiquitin-C P69310 UBIQ_AVESA
96.1 Polyubiquitin-C P69325 UBIQP_SOYBN
96.1 Polyubiquitin-C P69322 UBIQP_PEA
96.1 Polyubiquitin-C P69315 UBIQP_LINUS
96.1 Polyubiquitin-C P0CG83 UBIQP_HORVU
96.1 Polyubiquitin-C P69309 UBIQP_AVEFA
97.4 Polyubiquitin-C P0CG88 UBIQJ_DICDI
97.4 Polyubiquitin-C P0CG80 UBIQI_DICDI
97.4 Polyubiquitin-C P0CG81 UBIQH_DICDI
97.4 Polyubiquitin-C P0CG79 UBIQG_DICDI
97.4 Polyubiquitin-C P0CG78 UBIQF_DICDI
97.4 Polyubiquitin-C P0CG77 UBIQD_DICDI
97.4 Polyubiquitin-C P0CG76 UBIQA_DICDI
96.1 Polyubiquitin-C P0CG63 UBI4P_YEAST
96.1 Polyubiquitin-C P0CG72 UBI4P_SCHPO
96.1 Polyubiquitin-C P0CG84 UBI4P_NICSY
96.1 Polyubiquitin-C P0CG75 UBI4P_KLULA
96.1 Polyubiquitin-C P0CG74 UBI4P_CANAX
96.1 Polyubiquitin-C P0CH05 UBI2P_PETCR
96.1 Polyubiquitin-C P0CH04 UBI1P_PETCR
96.1 Polyubiquitin-C P0CG85 UBI1P_NICSY
96.1 Polyubiquitin-C P0CG73 UBI1P_CANAX
96.1 Polyubiquitin-C P0C031 RUB2_ORYSJ
96.1 Polyubiquitin-C Q8RUC6 RUB2_ARATH
96.1 Polyubiquitin-C P0C030 RUB1_ORYSJ
96.1 Polyubiquitin-C P0C073 RUB1_DESAN
96.1 Polyubiquitin-C Q9SHE7 RUB1_ARATH
96.1 Polyubiquitin-C P62981 RS27A_SOLTU
96.1 Polyubiquitin-C P62980 RS27A_SOLLC
96.1 Polyubiquitin-C P49636 RL40_NICSY
97.4 Polyubiquitin-C P14794 RL40_DICDI
96.1 Polyubiquitin-C P40909 RL40_CRYNJ
96.1 Polyubiquitin-C P51423 RL40_BRARP
96.1 Polyubiquitin-C P0CH09 RL40B_YEAST
96.1 Polyubiquitin-C P0CH35 RL40B_ORYSJ
96.1 Polyubiquitin-C Q42202 RL40B_ARATH
96.1 Polyubiquitin-C P0CH08 RL40A_YEAST
96.1 Polyubiquitin-C P0CH34 RL40A_ORYSJ
96.1 Polyubiquitin-C B9DHA6 RL40A_ARATH
96.1 Polyubiquitin-C P0CH07 RL402_SCHPO
96.1 Polyubiquitin-C P0CH06 RL401_SCHPO
96.1 Polyubiquitin-C P59271 R27AA_ARATH
97.4 Polyubiquitin-C P42740 UBIQP_AGLNE
97.4 Polyubiquitin-C P19848 UBIQ_COPCO
97.4 Polyubiquitin-C P0CG82 UBIQP_TETPY
97.4 Polyubiquitin-C P0DJ25 RL40_TETTS
97.4 Polyubiquitin-C P33190 RL40_TETPY
97.4 Polyubiquitin-C P0CH10 RL403_CHLRE
97.4 Polyubiquitin-C P0CH11 RL401_CHLRE
97.4 Polyubiquitin-C P69201 RL40_LEIMA
98.7 Polyubiquitin-C P59669 UBIQP_GEOCY
98.7 Polyubiquitin-C P0CG71 UBIQ1_CAEEL
98.7 Polyubiquitin-C P49632 RL40_CAEEL
100.0 Polyubiquitin-C P62982 RS27A_RAT
100.0 Polyubiquitin-C P62983 RS27A_MOUSE
100.0 Polyubiquitin-C P68200 RS27A_ICTPU
100.0 Polyubiquitin-C P62979 RS27A_HUMAN
100.0 Polyubiquitin-C P79781 RS27A_CHICK
100.0 Polyubiquitin-C P62978 RS27A_CAVPO
100.0 Polyubiquitin-C P62992 RS27A_BOVIN
98.7 Polyubiquitin-C Q8SWD4 UBIQ_ENCCU
98.7 Polyubiquitin-C P23398 UBIQP_STRPU
98.7 Polyubiquitin-C P46575 RL40_EIMBO
100.0 Polyubiquitin-C P62975 UBIQ_RABIT
100.0 Polyubiquitin-C P68197 UBIQ_CERCA
100.0 Polyubiquitin-C Q865C5 UBIQ_CAMDR
100.0 Polyubiquitin-C P62972 UBIQP_XENLA
100.0 Polyubiquitin-C P0CG69 UBIQP_DROME
100.0 Polyubiquitin-C P62976 UBIQP_CRIGR
100.0 Polyubiquitin-C Q63429 UBC_RAT
100.0 Polyubiquitin-C P0CG61 UBC_PONPY
100.0 Polyubiquitin-C P0CG68 UBC_PIG
100.0 Polyubiquitin-C P0CG64 UBC_PANTR
100.0 Polyubiquitin-C P0CG50 UBC_MOUSE
100.0 Polyubiquitin-C P0CG48 UBC_HUMAN
100.0 Polyubiquitin-C P0CG66 UBC_GORGO
100.0 Polyubiquitin-C P0CH28 UBC_BOVIN
100.0 Polyubiquitin-C P0CG55 UBB_SHEEP
100.0 Polyubiquitin-C P0CG51 UBB_RAT
100.0 Polyubiquitin-C P0CG60 UBB_PONPY
100.0 Polyubiquitin-C P0CG65 UBB_PANTR
100.0 Polyubiquitin-C P0CG49 UBB_MOUSE
100.0 Polyubiquitin-C P0CG47 UBB_HUMAN
100.0 Polyubiquitin-C Q8MKD1 UBB_HORSE
100.0 Polyubiquitin-C P0CG67 UBB_GORGO
100.0 Polyubiquitin-C P0CG62 UBB_CHICK
100.0 Polyubiquitin-C P0CG54 UBB_CAVPO
100.0 Polyubiquitin-C P0CG53 UBB_BOVIN
100.0 Polyubiquitin-C P68203 RS27A_SPOFR
100.0 Polyubiquitin-C P68202 RS27A_PLUXY
100.0 Polyubiquitin-C P29504 RS27A_MANSE
100.0 Polyubiquitin-C P15357 RS27A_DROME
100.0 Polyubiquitin-C P0C276 RL40_SHEEP
100.0 Polyubiquitin-C P62986 RL40_RAT
100.0 Polyubiquitin-C P0C275 RL40_PONPY
100.0 Polyubiquitin-C P63053 RL40_PIG
100.0 Polyubiquitin-C P68205 RL40_OPHHA
100.0 Polyubiquitin-C P62984 RL40_MOUSE
100.0 Polyubiquitin-C P0C273 RL40_MACFA
100.0 Polyubiquitin-C P62987 RL40_HUMAN
100.0 Polyubiquitin-C P63052 RL40_FELCA
100.0 Polyubiquitin-C P18101 RL40_DROME
100.0 Polyubiquitin-C P63050 RL40_CANLF
100.0 Polyubiquitin-C P63048 RL40_BOVIN