Denaturant mediated unfolding of both native and molten globule states of maltose binding protein are accompanied by large deltaCp's.


Abstract

Maltose binding protein (MBP) is a large, monomeric two domain protein containing 370 amino acids. In the absence of denaturant at neutral pH, the protein is in the native state, while at pH 3.0 it forms a molten globule. The molten globule lacks a tertiary circular dichroism signal but has secondary structure similar to that of the native state. The molten globule binds 8-anilino-1-naphthalene sulfonate (ANS). The unfolding thermodynamics of MBP at both pHs were measured by carrying out a series of isothermal urea melts at temperatures ranging from 274-329 K. At 298 K, values of deltaGdegrees , deltaCp, and Cm were 3.1+/-0.2 kcal mol(-1), 5.9+/-0.8 kcal mol(-1) K(-1) (15.9 cal (mol-residue)(-1) K(-1)), and 0.8 M, respectively, at pH 3.0 and 14.5+/-0.4 kcal mol(-1), 8.3+/-0.7 kcal mol(-1) K(-1) (22.4 kcal (mol-residue)(-1) K(-1)), and 3.3 M, respectively, at pH 7.1. Guanidine hydrochloride denaturation at pH 7.1 gave values of deltaGdegrees and deltaCp similar to those obtained with urea. The m values for denaturation are strongly temperature dependent, in contrast to what has been previously observed for small globular proteins. The value of deltaCp per mol-residue for the molten globule is comparable to corresponding values of deltaCp for the unfolding of typical globular proteins and suggests that it is a highly ordered structure, unlike molten globules of many small proteins. The value of deltaCp per mol-residue for the unfolding of the native state is among the highest currently known for any protein. Study holds ProTherm entries: 6763, 6764, 6765, 6766, 6767, 6768, 6769, 6770, 6771, 6772, 6773, 6774, 6775, 6776, 6777, 6778, 6779, 6780, 6781, 6782, 6783, 6784, 6785, 6786, 6787, 6788, 6789, 6790, 6791, 6792 Extra Details: heat capacity; molten globule; protein stability

Submission Details

ID: wBr343gR3

Submitter: Connie Wang

Submission Date: April 24, 2018, 8:32 p.m.

Version: 1

Publication Details
Sheshadri S;Lingaraju GM;Varadarajan R,Protein Sci. (1999) Denaturant mediated unfolding of both native and molten globule states of maltose binding protein are accompanied by large deltaCp's. PMID:10452613
Additional Information

Study Summary

Number of data points 90
Proteins Maltose-binding periplasmic protein ; Maltose-binding periplasmic protein
Unique complexes 1
Assays/Quantities/Protocols Experimental Assay: Cm pH:3.0, ionic:: , temp:303 K ; Experimental Assay: m pH:3.0, ionic:: , temp:303 K ; Experimental Assay: dG_H2O pH:3.0, ionic:: , temp:303 K ; Experimental Assay: Cm pH:3.0, ionic:: , temp:300 K ; Experimental Assay: m pH:3.0, ionic:: , temp:300 K ; Experimental Assay: dG_H2O pH:3.0, ionic:: , temp:300 K ; Experimental Assay: Cm temp:299 K, pH:3.0, ionic:: ; Experimental Assay: m temp:299 K, pH:3.0, ionic:: ; Experimental Assay: dG_H2O temp:299 K, pH:3.0, ionic:: ; Experimental Assay: Cm pH:3.0, ionic:: , temp:296 K ; Experimental Assay: m pH:3.0, ionic:: , temp:296 K ; Experimental Assay: dG_H2O pH:3.0, ionic:: , temp:296 K ; Experimental Assay: Cm pH:3.0, temp:291 K, ionic:: ; Experimental Assay: m pH:3.0, temp:291 K, ionic:: ; Experimental Assay: dG_H2O pH:3.0, ionic:: , temp:291 K ; Experimental Assay: Cm temp:287 K, pH:3.0, ionic:: ; Experimental Assay: m temp:287 K, pH:3.0, ionic:: ; Experimental Assay: dG_H2O temp:287 K, pH:3.0, ionic:: ; Experimental Assay: Cm pH:3.0, ionic:: , temp:282 K ; Experimental Assay: m pH:3.0, ionic:: , temp:282 K ; Experimental Assay: dG_H2O pH:3.0, ionic:: , temp:282 K ; Experimental Assay: Cm temp:276 K, pH:3.0, ionic:: ; Experimental Assay: m temp:276 K, pH:3.0, ionic:: ; Experimental Assay: dG_H2O temp:276 K, pH:3.0, ionic:: ; Experimental Assay: Cm ionic:KCl: 150 mM, pH:7.1, temp:318 K ; Experimental Assay: m ionic:KCl: 150 mM, pH:7.1, temp:318 K ; Experimental Assay: dG_H2O ionic:KCl: 150 mM, pH:7.1, temp:318 K ; Experimental Assay: Cm ionic:KCl: 150 mM, pH:7.1, temp:313 K ; Experimental Assay: m ionic:KCl: 150 mM, pH:7.1, temp:313 K ; Experimental Assay: dG_H2O ionic:KCl: 150 mM, pH:7.1, temp:313 K ; Experimental Assay: Cm temp:309 K, pH:7.1, ionic:KCl: 150 mM ; Experimental Assay: m temp:309 K, pH:7.1, ionic:KCl: 150 mM ; Experimental Assay: dG_H2O temp:309 K, pH:7.1, ionic:KCl: 150 mM ; Experimental Assay: Cm ionic:KCl: 150 mM, temp:304 K, pH:7.1 ; Experimental Assay: m ionic:KCl: 150 mM, temp:304 K, pH:7.1 ; Experimental Assay: dG_H2O ionic:KCl: 150 mM, temp:304 K, pH:7.1 ; Experimental Assay: Cm temp:298 K, pH:7.1, ionic:KCl: 150 mM ; Experimental Assay: m temp:298 K, pH:7.1, ionic:KCl: 150 mM ; Experimental Assay: dG_H2O temp:298 K, pH:7.1, ionic:KCl: 150 mM ; Experimental Assay: Cm ionic:KCl: 150 mM, pH:7.1, temp:293 K ; Experimental Assay: m ionic:KCl: 150 mM, pH:7.1, temp:293 K ; Experimental Assay: dG_H2O ionic:KCl: 150 mM, pH:7.1, temp:293 K ; Experimental Assay: Cm ionic:KCl: 150 mM, pH:7.1, temp:284 K ; Experimental Assay: m ionic:KCl: 150 mM, pH:7.1, temp:284 K ; Experimental Assay: dG_H2O ionic:KCl: 150 mM, pH:7.1, temp:284 K ; Experimental Assay: Cm ionic:KCl: 150 mM, temp:274 K, pH:7.1 ; Experimental Assay: m ionic:KCl: 150 mM, temp:274 K, pH:7.1 ; Experimental Assay: dG_H2O ionic:KCl: 150 mM, temp:274 K, pH:7.1 ; Experimental Assay: Cm ionic:KCl: 150 mM, pH:7.1, temp:329 K ; Experimental Assay: m ionic:KCl: 150 mM, pH:7.1, temp:329 K ; Experimental Assay: dG_H2O ionic:KCl: 150 mM, pH:7.1, temp:329 K ; Experimental Assay: Cm ionic:KCl: 150 mM, temp:328 K, pH:7.1 ; Experimental Assay: m ionic:KCl: 150 mM, temp:328 K, pH:7.1 ; Experimental Assay: dG_H2O ionic:KCl: 150 mM, temp:328 K, pH:7.1 ; Experimental Assay: Cm ionic:KCl: 150 mM, temp:319 K, pH:7.1 ; Experimental Assay: m ionic:KCl: 150 mM, temp:319 K, pH:7.1 ; Experimental Assay: dG_H2O ionic:KCl: 150 mM, temp:319 K, pH:7.1 ; Experimental Assay: Cm ionic:KCl: 150 mM, pH:7.1, temp:313 K ; Experimental Assay: m ionic:KCl: 150 mM, pH:7.1, temp:313 K ; Experimental Assay: dG_H2O ionic:KCl: 150 mM, pH:7.1, temp:313 K ; Experimental Assay: Cm temp:312 K, pH:7.1, ionic:KCl: 150 mM ; Experimental Assay: m temp:312 K, pH:7.1, ionic:KCl: 150 mM ; Experimental Assay: dG_H2O temp:312 K, pH:7.1, ionic:KCl: 150 mM ; Experimental Assay: Cm ionic:KCl: 150 mM, pH:7.1, temp:310 K ; Experimental Assay: m ionic:KCl: 150 mM, pH:7.1, temp:310 K ; Experimental Assay: dG_H2O ionic:KCl: 150 mM, pH:7.1, temp:310 K ; Experimental Assay: Cm ionic:KCl: 150 mM, temp:307 K, pH:7.1 ; Experimental Assay: m ionic:KCl: 150 mM, temp:307 K, pH:7.1 ; Experimental Assay: dG_H2O ionic:KCl: 150 mM, temp:307 K, pH:7.1 ; Experimental Assay: Cm temp:306 K, ionic:KCl: 150 mM, pH:7.1 ; Experimental Assay: m temp:306 K, ionic:KCl: 150 mM, pH:7.1 ; Experimental Assay: dG_H2O temp:306 K, ionic:KCl: 150 mM, pH:7.1 ; Experimental Assay: Cm ionic:KCl: 150 mM, pH:7.1, temp:303 K ; Experimental Assay: m ionic:KCl: 150 mM, pH:7.1, temp:303 K ; Experimental Assay: dG_H2O ionic:KCl: 150 mM, pH:7.1, temp:303 K ; Experimental Assay: Cm ionic:KCl: 150 mM, temp:299 K, pH:7.1 ; Experimental Assay: m ionic:KCl: 150 mM, temp:299 K, pH:7.1 ; Experimental Assay: dG_H2O ionic:KCl: 150 mM, temp:299 K, pH:7.1 ; Experimental Assay: Cm ionic:KCl: 150 mM, pH:7.1, temp:293 K ; Experimental Assay: m ionic:KCl: 150 mM, pH:7.1, temp:293 K ; Experimental Assay: dG_H2O ionic:KCl: 150 mM, pH:7.1, temp:293 K ; Experimental Assay: Cm temp:287 K, ionic:KCl: 150 mM, pH:7.1 ; Experimental Assay: m temp:287 K, ionic:KCl: 150 mM, pH:7.1 ; Experimental Assay: dG_H2O temp:287 K, ionic:KCl: 150 mM, pH:7.1 ; Experimental Assay: Cm ionic:KCl: 150 mM, pH:7.1, temp:282 K ; Experimental Assay: m ionic:KCl: 150 mM, pH:7.1, temp:282 K ; Experimental Assay: dG_H2O ionic:KCl: 150 mM, pH:7.1, temp:282 K ; Experimental Assay: Cm ionic:KCl: 150 mM, temp:277 K, pH:7.1 ; Experimental Assay: m ionic:KCl: 150 mM, temp:277 K, pH:7.1 ; Experimental Assay: dG_H2O ionic:KCl: 150 mM, temp:277 K, pH:7.1
Libraries Mutations for sequence KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK

Structure view and single mutant data analysis

Study data

No weblogo for data of varying length.
Colors: D E R H K S T N Q A V I L M F Y W C G P
 

Data Distribution

Studies with similar sequences (approximate matches)

Correlation with other assays (exact sequence matches)


Relevant PDB Entries

Structure ID Release Date Resolution Structure Title
1EZP 2001-05-08 GLOBAL FOLD OF MALTODEXTRIN BINDING PROTEIN COMPLEXED WITH BETA-CYCLODEXTRIN USING PEPTIDE ORIENTATIONS FROM DIPOLAR COUPLINGS
1EZO 2001-05-03 GLOBAL FOLD OF MALTODEXTRIN BINDING PROTEIN COMPLEXED WITH BETA-CYCLODEXTRIN
2N45 2015-07-01 EC-NMR Structure of Escherichia coli Maltose-binding protein Determined by Combining Evolutionary Couplings (EC) and Sparse NMR Data with a second set of RDC data simulated for an alternative alignment tensor. Northeast Structural Genomics Consortium target ER690
2KLF 2009-10-06 PERE NMR structure of maltodextrin-binding protein
2H25 2006-10-31 Solution Structure of Maltose Binding Protein complexed with beta-cyclodextrin
2V93 2007-11-06 EQUILLIBRIUM MIXTURE OF OPEN AND PARTIALLY-CLOSED SPECIES IN THE APO STATE OF MALTODEXTRIN-BINDING PROTEIN BY PARAMAGNETIC RELAXATION ENHANCEMENT NMR
2N44 2015-07-01 EC-NMR Structure of Escherichia coli Maltose-binding protein Determined by Combining Evolutionary Couplings (EC) and Sparse NMR Data. Northeast Structural Genomics Consortium target ER690
5ZR0 2018-08-22 Solution structure of peptidyl-prolyl cis/trans isomerase domain of Trigger Factor in complex with MBP
2D21 2006-03-07 NMR Structure of stereo-array isotope labelled (SAIL) maltodextrin-binding protein (MBP)
5JTQ 2016-08-24 The structure of chaperone SecB in complex with unstructured MBP binding site d
2MV0 2014-12-10 Solution NMR Structure of Maltose-binding protein from Escherichia coli, Northeast Structural Genomics Consortium (NESG) Target ER690
5JTR 2016-08-24 The structure of chaperone SecB in complex with unstructured MBP binding site e
4EXK 2012-08-08 1.28 A chimera protein containing MBP fused to the C-terminal domain of the uncharacterized protein STM14_2015 from Salmonella enterica
3Q27 2011-06-01 1.3 Cyrstal structure of human alpha-synuclein (32-57) fused to maltose binding protein (MBP)
5M13 2017-11-15 1.37 Synthetic nanobody in complex with MBP
5H7Q 2017-02-15 1.45 Crystal structure of human MNDA PYD domain with MBP tag
4IRL 2013-08-07 1.47 X-ray structure of the CARD domain of zebrafish GBP-NLRP1 like protein
3MP6 2011-05-04 1.48 Complex Structure of Sgf29 and dimethylated H3K4
3KJT 2010-02-09 1.5 Stimulation of the maltose transporter by a mutant sucrose binding protein gives insights into ABC transporter coupling
3O3U 2010-10-13 1.5 Crystal Structure of Human Receptor for Advanced Glycation Endproducts (RAGE)
3Q26 2011-06-01 1.54 Cyrstal structure of human alpha-synuclein (10-42) fused to maltose binding protein (MBP)
3SEW 2011-09-21 1.55 Zn-mediated Polymer of Maltose-binding Protein A216H/K220H by Synthetic Symmetrization (Form I)
4WMU 2015-05-06 1.55 STRUCTURE OF MBP-MCL1 BOUND TO ligand 2 AT 1.55A
3Q28 2011-06-01 1.6 Cyrstal structure of human alpha-synuclein (58-79) fused to maltose binding protein (MBP)
5M14 2017-11-15 1.6 Synthetic nanobody in complex with MBP
4EDQ 2013-03-20 1.64 MBP-fusion protein of myosin-binding protein c residues 149-269
5WQ6 2017-02-15 1.65 Crystal Structure of hMNDA-PYD with MBP tag
1ANF 1997-12-24 1.67 MALTODEXTRIN BINDING PROTEIN WITH BOUND MALTOSE
5VAW 2018-03-28 1.69 Fusion of Maltose-binding Protein and PilA from Acinetobacter baumannii AB5075
5AZ8 2016-01-13 1.7 Crystal structure of MBP-Tom20 fusion protein tethered with ALDH presequence via a disulfide bond
4MBP 1998-02-25 1.7 MALTODEXTRIN BINDING PROTEIN WITH BOUND MALTETROSE
4RG5 2015-07-01 1.7 Crystal Structure of S. Pombe SMN YG-Dimer
6QXJ 2019-08-07 1.7 Structure of MBP-Mcl-1 in complex with compound 6a
4XHS 2016-01-27 1.7 Crystal structure of human NLRP12 PYD domain and implication in homotypic interaction
3MBP 1997-12-24 1.7 MALTODEXTRIN-BINDING PROTEIN WITH BOUND MALTOTRIOSE
4PE2 2015-01-14 1.72 MBP PilA1 CD160
6N84 2019-07-10 1.75 MBP-fusion protein of transducin-alpha residues 327-350
3JYR 2010-02-16 1.75 Crystal structures of the GacH receptor of Streptomyces glaucescens GLA.O in the unliganded form and in complex with acarbose and an acarbose homolog. Comparison with acarbose-loaded maltose binding protein of Salmonella typhimurium.
4QVH 2014-12-17 1.75 Crystal structure of the essential Mycobacterium tuberculosis phosphopantetheinyl transferase PptT, solved as a fusion protein with maltose binding protein
3G7W 2009-06-23 1.75 Islet Amyloid Polypeptide (IAPP or Amylin) Residues 1 to 22 fused to Maltose Binding Protein
4RWF 2015-05-20 1.76 Crystal structure of the CLR:RAMP2 extracellular domain heterodimer with bound adrenomedullin
5ZCA 2018-08-15 1.8 Crystal structure of lambda repressor (1-20) fused with maltose-binding protein
1OMP 1994-01-31 1.8 CRYSTALLOGRAPHIC EVIDENCE OF A LARGE LIGAND-INDUCED HINGE-TWIST MOTION BETWEEN THE TWO DOMAINS OF THE MALTODEXTRIN-BINDING PROTEIN INVOLVED IN ACTIVE TRANSPORT AND CHEMOTAXIS
1LLS 2002-09-18 1.8 CRYSTAL STRUCTURE OF UNLIGANDED MALTOSE BINDING PROTEIN WITH XENON
1DMB 1993-10-31 1.8 REFINED 1.8 ANGSTROMS STRUCTURE REVEALS THE MECHANISM OF BINDING OF A CYCLIC SUGAR, BETA-CYCLODEXTRIN, TO THE MALTODEXTRIN BINDING PROTEIN
5II5 2017-06-14 1.8 Crystal structure of red abalone VERL repeat 1 at 1.8 A resolution
3CSG 2008-07-22 1.8 Crystal Structure of Monobody YS1(MBP-74)/Maltose Binding Protein Fusion Complex
3W15 2013-07-03 1.8 Structure of peroxisomal targeting signal 2 (PTS2) of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase in complex with Pex7p and Pex21p
1YTV 2005-04-12 1.8 Maltose-binding protein fusion to a C-terminal fragment of the V1a vasopressin receptor
3N94 2011-06-08 1.8 Crystal structure of human pituitary adenylate cyclase 1 Receptor-short N-terminal extracellular domain
6QGD 2019-06-12 1.8 Structure of human Mcl-1 in complex with thienopyrimidine inhibitor
5CFV 2016-07-13 1.8 Fusion of Maltose-binding Protein and PilA from Acinetobacter nosocomialis M2
5AZ9 2016-01-13 1.82 Crystal structure of (5-residue deleted)MBP-Tom20 fusion protein tethered with ALDH presequence via a disulfide bond
5H7N 2017-02-15 1.85 Crystal structure of human NLRP12-PYD with a MBP tag
4WGI 2014-11-19 1.85 A Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)
1LAX 2003-03-04 1.85 CRYSTAL STRUCTURE OF MALE31, A DEFECTIVE FOLDING MUTANT OF MALTOSE-BINDING PROTEIN
3SEU 2011-09-21 1.85 Zn-mediated Polymer of Maltose-binding Protein A216H/K220H by Synthetic Symmetrization (Form III)
3SEY 2011-09-21 1.85 Zn-mediated Polymer of Maltose-binding Protein A216H/K220H by Synthetic Symmetrization (Form II)
3RUM 2012-06-06 1.85 New strategy to analyze structures of glycopeptide antibiotic-target complexes
5AQ9 2016-03-23 1.86 DARPin-based Crystallization Chaperones exploit Molecular Geometry as a Screening Dimension in Protein Crystallography
3G7V 2009-06-23 1.86 Islet Amyloid Polypeptide (IAPP or Amylin) fused to Maltose Binding Protein
1FQB 2001-03-14 1.9 STRUCTURE OF MALTOTRIOTOL BOUND TO OPEN-FORM MALTODEXTRIN BINDING PROTEIN IN P2(1)CRYSTAL FORM
4TSM 2015-01-14 1.9 MBP-fusion protein of PilA1 from C. difficile R20291 residues 26-166
1EZ9 2002-01-30 1.9 STRUCTURE OF MALTOTETRAITOL BOUND TO OPEN-FORM MALTODEXTRIN BINDING PROTEIN IN P1 CRYSTAL FORM
4WMS 2015-05-06 1.9 STRUCTURE OF APO MBP-MCL1 AT 1.9A
3WAI 2013-07-17 1.9 Crystal structure of the C-terminal globular domain of oligosaccharyltransferase (AfAglB-L, O29867_ARCFU) from Archaeoglobus fulgidus as a MBP fusion
1JVY 2001-09-12 1.9 Maltodextrin-binding protein variant D207C/A301GS/P316C with beta-mercaptoethanol mixed disulfides
4WMW 2015-05-06 1.9 The structure of MBP-MCL1 bound to ligand 5 at 1.9A
5M15 2017-11-15 1.9 Synthetic nanobody in complex with MBP
3Q25 2011-06-01 1.9 Crystal structure of human alpha-synuclein (1-19) fused to maltose binding protein (MBP)
3SET 2011-09-21 1.9 Ni-mediated Dimer of Maltose-binding Protein A216H/K220H by Synthetic Symmetrization (Form I)
1Y4C 2005-02-15 1.9 Designed Helical Protein fusion MBP
4WVI 2015-09-23 1.9 Crystal structure of the Type-I signal peptidase from Staphylococcus aureus (SpsB) in complex with a substrate peptide (pep2).
3SES 2011-09-21 1.9 Cu-mediated Dimer of Maltose-binding Protein A216H/K220H by Synthetic Symmetrization
3OSQ 2011-10-26 1.9 Maltose-bound maltose sensor engineered by insertion of circularly permuted green fluorescent protein into E. coli maltose binding protein at position 175
1MDQ 1994-11-01 1.9 REFINED STRUCTURES OF TWO INSERTION(SLASH)DELETION MUTANTS PROBE FUNCTION OF THE MALTODEXTRIN BINDING PROTEIN
1FQA 2001-03-14 1.9 STRUCTURE OF MALTOTETRAITOL BOUND TO OPEN-FORM MALTODEXTRIN BINDING PROTEIN IN P2(1)CRYSTAL FORM
4GLI 2012-10-17 1.9 Crystal Structure of Human SMN YG-Dimer
5B3Y 2016-10-26 1.9 Crystal structure of hPin1 WW domain (5-23) fused with maltose-binding protein
3MP8 2011-05-04 1.92 Crystal structure of Sgf29 tudor domain
5C7R 2015-09-30 1.94 Revealing surface waters on an antifreeze protein by fusion protein crystallography
3H3G 2009-08-11 1.94 Crystal structure of the extracellular domain of the human parathyroid hormone receptor (PTH1R) in complex with parathyroid hormone-related protein (PTHrP)
3SEX 2011-09-21 1.95 Ni-mediated Dimer of Maltose-binding Protein A216H/K220H by Synthetic Symmetrization (Form II)
3C4M 2008-04-08 1.95 Structure of human parathyroid hormone in complex with the extracellular domain of its G-protein-coupled receptor (PTH1R)
5BJZ 2018-01-17 1.95 Crystal structure of maltose binding protein in complex with an allosteric synthetic antibody
2XZ3 2011-03-02 1.95 BLV TM hairpin
4WVJ 2015-09-23 1.95 Crystal structure of the Type-I signal peptidase from Staphylococcus aureus (SpsB) in complex with an inhibitor peptide (pep3).
5T0A 2017-02-01 1.95 Crystal Structure of Heparan Sulfate 6-O-Sulfotransferase with bound PAP and heptasaccharide substrate
5T05 2017-02-01 1.95 Crystal structure of heparan sulfate 6-O-sulfotransferase with bound PAP and IdoA2S containing hexasaccharide substrate
4KYC 2013-09-25 1.95 Structure of the C-terminal domain of the Menangle virus phosphoprotein, fused to MBP.
5AZ7 2016-01-13 1.96 Crystal structure of MBP-Tom20 fusion protein with a 4-residue spacer in the connector helix
5GRU 2016-10-12 1.96 Structure of mono-specific diabody
3EHU 2008-09-30 1.96 Crystal structure of the extracellular domain of human corticotropin releasing factor receptor type 1 (CRFR1) in complex with CRF
4XA2 2016-01-20 1.98 Structure of the Major Type IV pilin of Acinetobacter baumannii
4IFP 2013-04-03 1.99 X-ray Crystal Structure of Human NLRP1 CARD Domain
4EGC 2013-02-27 1.99 Crystal Structure of MBP-fused Human Six1 Bound to Human Eya2 Eya Domain
1ZIU 2005-12-20 2.0 Crystal Structure of nickel-bound engineered Maltose Binding Protein
3HPI 2010-02-09 2.0 Crystal structure of maltose-binding protein mutant with bound sucrose
1JW4 2002-01-30 2.0 Structure of ligand-free maltodextrin-binding protein
5WPZ 2017-02-15 2.0 Crystal structure of MNDA PYD with MBP tag
3LC8 2011-02-16 2.0 Crystal structure of the cytoplasmic tail of (pro)renin receptor as a MBP fusion (Maltose-free form)
1ZJL 2005-12-20 2.0 Crystal structure of zinc-bound engineered maltose binding protein
3CSB 2008-07-22 2.0 Crystal Structure of Monobody YSX1/Maltose Binding Protein Fusion Complex
5BMY 2016-10-26 2.0 Crystal structure of hPin1 WW domain (5-21) fused with maltose-binding protein
1MPB 1995-10-15 2.0 MALTODEXTRIN-BINDING PROTEIN (MALTOSE-BINDING PROTEIN) MUTANT, WITH ARGININE REPLACING TRYPTOPHAN AT POSITION 230 (TRP-230-ARG)
4R0Y 2014-09-10 2.0 Structure of Maltose-binding Protein Fusion with the C-terminal GH1 domain of Guanylate Kinase-associated Protein from Rattus norvegicus
2OK2 2007-04-10 2.0 MutS C-terminal domain fused to Maltose Binding Protein
5II4 2017-06-14 2.0 Crystal structure of red abalone VERL repeat 1 with linker at 2.0 A resolution
4WMX 2015-05-06 2.0 The structure of MBP-MCL1 bound to ligand 6 at 2.0A
3WOA 2015-04-29 2.0 Crystal structure of lambda repressor (1-45) fused with maltose-binding protein
3OSR 2011-10-26 2.0 Maltose-bound maltose sensor engineered by insertion of circularly permuted green fluorescent protein into E. coli maltose binding protein at position 311
1JW5 2002-01-30 2.0 Structure of Maltose Bound to Open-form Maltodextrin-binding Protein in P1 Crystal
5GPP 2017-08-09 2.0 Crystal structure of zebrafish ASC PYD domain
4YS9 2016-03-09 2.0 Ataxin-3 Carboxy-Terminal Region - Crystal C1 (tetragonal)
5TTD 2017-03-01 2.0 Minor pilin FctB from S. pyogenes with engineered intramolecular isopeptide bond
5JON 2016-11-30 2.04 Crystal structure of the unliganded form of HCN2 CNBD
3VFJ 2013-01-09 2.05 The structure of monodechloro-teicoplanin in complex with its ligand, using MBP as a ligand carrier
6D1U 2018-09-05 2.05 Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer in complex with adrenomedullin 2/intermedin
5OSQ 2017-09-06 2.05 ZP-N domain of mammalian sperm receptor ZP3 (crystal form II, processed in P21221)
5Z0R 2018-04-11 2.05 Structural insight into the Zika virus capsid encapsulating the viral genome
4WVG 2015-09-23 2.05 Crystal structure of the Type-I signal peptidase from Staphylococcus aureus (SpsB).
3VD8 2013-01-16 2.07 Crystal structure of human AIM2 PYD domain with MBP fusion
5AZA 2016-01-13 2.08 Crystal structure of MBP-sAglB fusion protein with a 20-residue spacer in the connector helix
5YGP 2018-10-03 2.09 Human TNFRSF25 death domain mutant-D412E
3PGF 2011-03-09 2.1 Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB)
5T03 2017-02-01 2.1 Crystal structure of heparan sulfate 6-O-sulfotransferase with bound PAP and glucuronic acid containing hexasaccharide substrate
5FIO 2016-11-16 2.1 DARPins as a new tool for experimental phasing in protein crystallography
5GXV 2017-07-19 2.1 Crystal structure of PigG
5GPQ 2017-08-09 2.1 Crystal Structure of zebrafish ASC CARD Domain
5K94 2017-06-07 2.1 Deletion-Insertion Chimera of MBP with the Preprotein Cross-Linking Domain of the SecA ATPase
1MPC 1995-10-15 2.1 MALTODEXTRIN-BINDING PROTEIN (MALTOSE-BINDING PROTEIN) MUTANT, WITH ARGININE REPLACING TRYPTOPHAN AT POSITION 230 (TRP-230-ARG)
1MH3 2002-09-18 2.1 maltose binding-a1 homeodomain protein chimera, crystal form I
4WVH 2015-09-23 2.1 Crystal structure of the Type-I signal peptidase from Staphylococcus aureus (SpsB) in complex with a substrate peptide (pep1).
6QYO 2019-08-07 2.1 Structure of MBP-Mcl-1 in complex with compound 18a
1NL5 2003-08-12 2.1 Engineered High-affinity Maltose-Binding Protein
2VGQ 2007-12-11 2.1 Crystal Structure of Human IPS-1 CARD
3OAI 2011-12-21 2.1 Crystal structure of the extra-cellular domain of human myelin protein zero
4XZS 2016-01-20 2.12 Crystal Structure of TRIAP1-MBP fusion
5E24 2016-06-15 2.14 Structure of the Su(H)-Hairless-DNA Repressor Complex
3LBS 2011-02-16 2.15 Crystal structure of the cytoplasmic tail of (pro)renin receptor as a MBP fusion (Maltose-bound form)
5BK1 2018-01-17 2.15 Crystal structure of maltose binding protein in complex with an endosteric synthetic antibody
4H1G 2012-10-10 2.15 Structure of Candida albicans Kar3 motor domain fused to maltose-binding protein
5ZD4 2018-08-29 2.17 Crystal structure of MBP-fused BIL1/BZR1 in complex with double-stranded DNA
6QZ7 2019-08-07 2.2 Structure of MBP-Mcl-1 in complex with compound 8b
5IHJ 2016-09-21 2.2 Fusion of Maltose-binding Protein and PilA from Acinetobacter baumannii BIDMC57
3RLF 2011-08-10 2.2 Crystal structure of the maltose-binding protein/maltose transporter complex in an outward-facing conformation bound to MgAMPPNP
6QYL 2019-08-07 2.2 Structure of MBP-Mcl-1 in complex with compound 8a
1ZKB 2005-12-20 2.2 Zinc-free Engineered maltose binding protein
5LOF 2016-10-26 2.2 Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1
4KV3 2014-04-09 2.2 Ubiquitin-like domain of the Mycobacterium tuberculosis type VII secretion system protein EccD1 as maltose-binding protein fusion
5JST 2017-03-22 2.2 MBP fused MDV1 coiled coil
4KYD 2013-09-25 2.21 Partial Structure of the C-terminal domain of the HPIV4B phosphoprotein, fused to MBP.
4OGM 2015-01-14 2.23 MBP-fusion protein of PilA1 residues 26-159
6D66 2018-09-19 2.23 Crystal structure of the human dual specificity 1 catalytic domain (C258S) as a maltose binding protein fusion in complex with the designed AR protein mbp3_16
1SVX 2004-05-25 2.24 Crystal structure of a designed selected Ankyrin Repeat protein in complex with the Maltose Binding Protein
5GXT 2017-07-19 2.24 Crystal structure of PigG
3HST 2010-04-28 2.25 N-Terminal RNASE H domain of rv2228c from mycobacterium tuberculosis as a fusion protein with maltose binding protein
4XR8 2016-02-03 2.25 Crystal structure of the HPV16 E6/E6AP/p53 ternary complex at 2.25 A resolution
4WTH 2016-03-09 2.25 Ataxin-3 Carboxy Terminal Region - Crystal C2 (triclinic)
4JKM 2014-09-17 2.26 Crystal Structure of Clostridium perfringens beta-glucuronidase
6ANV 2017-10-25 2.27 Crystal structure of anti-CRISPR protein AcrF1
6NDJ 2019-01-23 2.27 Crystal structure of human NLRP6 PYD domain with MBP fusion
4DXB 2012-08-08 2.29 2.29A structure of the engineered MBP TEM-1 fusion protein RG13 in complex with zinc, P1 space group
3PY7 2011-12-14 2.29 Crystal structure of full-length Bovine Papillomavirus oncoprotein E6 in complex with LD1 motif of paxillin at 2.3A resolution
6EQZ 2017-11-01 2.29 A MamC-MIC insertion in MBP scaffold at position K170
5DFM 2015-10-28 2.3 Structure of Tetrahymena telomerase p19 fused to MBP
3D4G 2008-12-02 2.3 ZP-N domain of mammalian sperm receptor ZP3 (crystal form II)
3PUX 2011-08-10 2.3 Crystal Structure of an outward-facing MBP-Maltose transporter complex bound to ADP-BeF3
1MH4 2002-09-18 2.3 maltose binding-a1 homeodomain protein chimera, crystal form II
3Q29 2011-06-01 2.3 Cyrstal structure of human alpha-synuclein (1-19) fused to maltose binding protein (MBP)
1FQD 2001-03-14 2.3 CRYSTAL STRUCTURE OF MALTOTETRAITOL BOUND TO CLOSED-FORM MALTODEXTRIN BINDING PROTEIN
1MDP 1994-11-01 2.3 REFINED STRUCTURES OF TWO INSERTION(SLASH)DELETION MUTANTS PROBE FUNCTION OF THE MALTODEXTRIN BINDING PROTEIN
6AEO 2019-06-12 2.3 TssL periplasmic domain
1HSJ 2001-06-06 2.3 SARR MBP FUSION STRUCTURE
5CBN 2016-03-30 2.3 Fusion protein of mbp3-16 and B4 domain of protein A from staphylococcal aureus with chemical cross-linker EY-CBS
5B3Z 2016-10-26 2.3 Crystal structure of hPin1 WW domain (5-39) fused with maltose-binding protein
6QYK 2019-08-07 2.3 Structure of MBP-Mcl-1 in complex with compound 7a
1MPD 1995-10-15 2.3 MALTODEXTRIN-BINDING PROTEIN (MALTOSE-BINDING PROTEIN) MUTANT, WITH ARGININE REPLACING TRYPTOPHAN AT POSITION 230 (TRP-230-ARG), COMPLEXED WITH MALTOSE
3PUW 2011-08-10 2.3 Crystal Structure of an outward-facing MBP-Maltose transporter complex bound to ADP-AlF4
4DXC 2012-08-08 2.3 Crystal structure of the engineered MBP TEM-1 fusion protein RG13, C2 space group
1FQC 2001-03-14 2.3 CRYSTAL STRUCTURE OF MALTOTRIOTOL BOUND TO CLOSED-FORM MALTODEXTRIN BINDING PROTEIN
1NMU 2003-02-18 2.31 MBP-L30
5IQZ 2016-07-27 2.33 Crystal structure of N-terminal domain of Human SIRT7
6D65 2018-09-19 2.35 Crystal structure of the human dual specificity phosphatase 1 catalytic domain (C258S) as a maltose binding protein fusion in complex with the designed AR protein off7
3SER 2011-09-21 2.35 Zn-mediated Polymer of Maltose-binding Protein K26H/K30H by Synthetic Symmetrization
2OBG 2007-03-27 2.35 Crystal Structure of Monobody MBP-74/Maltose Binding Protein Fusion Complex
3H4Z 2010-03-31 2.35 Crystal Structure of an MBP-Der p 7 fusion protein
4WMT 2015-05-06 2.35 STRUCTURE OF MBP-MCL1 BOUND TO ligand 1 AT 2.35A
4KI0 2013-10-23 2.38 Crystal structure of the maltose-binding protein/maltose transporter complex in an outward-facing conformation bound to maltohexaose
3DM0 2008-09-09 2.4 Maltose Binding Protein fusion with RACK1 from A. thaliana
5W0R 2017-08-16 2.4 Crystal structure of MBP fused activation-induced cytidine deaminase (AID) in complex with cacodylic acid
4WMV 2015-05-06 2.4 STRUCTURE OF MBP-MCL1 BOUND TO ligand 4 AT 2.4A
3PUV 2011-08-10 2.4 Crystal Structure of an outward-facing MBP-Maltose transporter complex bound to ADP-VO4
4JBZ 2013-12-11 2.4 Structure of Mcm10 coiled-coil region
5B3X 2016-10-26 2.4 Crystal structure of hPin1 WW domain (5-15) fused with maltose-binding protein in P41212 form
4MY2 2013-11-13 2.4 Crystal Structure of Norrin in fusion with Maltose Binding Protein
5B3W 2016-10-26 2.4 Crystal structure of hPin1 WW domain (5-15) fused with maltose-binding protein in C2221 form
5I04 2017-06-07 2.42 Crystal structure of the orphan region of human endoglin/CD105
4RWG 2015-05-20 2.44 Crystal structure of the CLR:RAMP1 extracellular domain heterodimer with bound high affinity CGRP analog
4IKM 2013-05-08 2.46 X-ray structure of CARD8 CARD domain
6APX 2017-11-01 2.49 Crystal structure of human dual specificity phosphatase 1 catalytic domain (C258S) as a maltose binding protein fusion in complex with the monobody YSX1
3A3C 2009-08-04 2.5 Crystal structure of TIM40/MIA40 fusing MBP, C296S and C298S mutant
4KEG 2014-04-30 2.5 Crystal Structure of MBP Fused Human SPLUNC1
6N85 2019-07-10 2.5 Resistance to inhibitors of cholinesterase 8A (Ric8A) protein in complex with MBP-tagged transducin-alpha residues 327-350
1ZMG 2005-12-20 2.5 Crystal structure of copper-bound engineered maltose binding protein
6QYN 2019-08-07 2.5 Structure of MBP-Mcl-1 in complex with compound 10d
1N3X 2003-08-12 2.5 Ligand-free High-Affinity Maltose-Binding Protein
1MG1 1999-04-06 2.5 HTLV-1 GP21 ECTODOMAIN/MALTOSE-BINDING PROTEIN CHIMERA
1JVX 2001-09-12 2.5 Maltodextrin-binding protein variant D207C/A301GS/P316C cross-linked in crystal
5YEV 2018-09-19 2.5 Murine DR3 death domain
4N4X 2014-09-17 2.5 Crystal Structure of the MBP fused human SPLUNC1 (native form)
5ZNZ 2019-04-17 2.55 Structure of mDR3 DD with MBP tag mutant-I387V
4GIZ 2013-01-23 2.55 Crystal structure of full-length human papillomavirus oncoprotein E6 in complex with LXXLL peptide of ubiquitin ligase E6AP at 2.55 A resolution
6D67 2018-09-19 2.55 Crystal structure of the human dual specificity phosphatase 1 catalytic domain (C258S) as a maltose binding protein fusion (maltose bound form) in complex with the designed AR protein mbp3_16
5AZ6 2016-01-13 2.56 Crystal structure of MBP-Tom20 fusion protein with a 2-residue spacer in the connector helix
1PEB 2003-08-12 2.6 LIGAND-FREE HIGH-AFFINITY MALTOSE-BINDING PROTEIN
4KYE 2013-09-25 2.6 Partial Structure of the C-terminal domain of the HPIV4B phosphoprotein, fused to MBP.
5BK2 2018-01-17 2.6 Crystal structure of maltose binding protein in complex with a peristeric synthetic antibody
4XAI 2015-03-04 2.6 Crystal Structure of red flour beetle NR2E1/TLX
1N3W 2003-08-12 2.6 Engineered High-Affinity Maltose-Binding Protein
3MP1 2011-05-04 2.6 Complex structure of Sgf29 and trimethylated H3K4
3F5F 2008-12-16 2.65 Crystal structure of heparan sulfate 2-O-sulfotransferase from gallus gallus as a maltose binding protein fusion.
5YGS 2018-10-03 2.69 Human TNFRSF25 death domain
1IUD 1997-06-05 2.7 MALTODEXTRIN-BINDING PROTEIN INSERTION/DELETION MUTANT WITH AN INSERTED B-CELL EPITOPE FROM THE PRES2 REGION OF HEPATITIS B VIRUS
4O2X 2014-12-24 2.7 Structure of a malarial protein
4LOG 2013-10-09 2.7 The crystal structure of the orphan nuclear receptor PNR ligand binding domain fused with MBP
6DM8 2018-08-01 2.7 Understanding the Species Selectivity of Myeloid cell leukemia-1 (Mcl-1) inhibitors
5I69 2016-03-23 2.7 MBP-MamC magnetite-interaction component mutant-D70A
5HZV 2017-06-07 2.7 Crystal structure of the zona pellucida module of human endoglin/CD105
3OB4 2011-02-02 2.71 MBP-fusion protein of the major peanut allergen Ara h 2
5ZNY 2019-04-17 2.74 Structure of mDR3_DD-C363G with MBP tag
3EHS 2008-09-30 2.76 Crystal structure of the extracellular domain of human corticotropin releasing factor receptor type 1 (CRFR1)
6DKS 2019-01-02 2.78 Structure of the Rbpj-SHARP-DNA Repressor Complex
5EDU 2016-07-27 2.79 Crystal structure of human histone deacetylase 6 catalytic domain 2 in complex with trichostatin A
2R6G 2007-11-27 2.8 The Crystal Structure of the E. coli Maltose Transporter
4BL9 2013-11-27 2.8 Crystal structure of full-length human Suppressor of fused (SUFU) mutant lacking a regulatory subdomain (crystal form I)
5WVN 2018-01-03 2.8 Crystal structure of MBS-BaeS fusion protein
5E7U 2016-03-23 2.8 MBP-MamC loop structure, a magnetite biomineralizing protein from Magnetospirillium magneticum AMB-1
4FEB 2013-03-13 2.8 Crystal Structure of Htt36Q3H-EX1-X1-C2(Beta)
4BLB 2013-11-27 2.8 Crystal structure of a human Suppressor of fused (SUFU)-GLI1p complex
5V6Y 2018-01-31 2.8 Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity and altered selectivity adrenomedullin variant
6CXS 2019-04-17 2.8 Crystal Structure of Clostridium perfringens beta-glucuronidase bound with a novel, potent inhibitor 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine
4NUF 2014-01-29 2.8 Crystal Structure of SHP/EID1
1R6Z 2004-01-13 2.8 The Crystal Structure of the Argonaute2 PAZ domain (as a MBP fusion)
3MQ9 2010-10-27 2.8 Crystal Structure of Ectodomain Mutant of BST-2/Tetherin/CD317 Fused to MBP
4BLD 2013-11-27 2.8 Crystal structure of a human Suppressor of fused (SUFU)-GLI3p complex
5JJ4 2016-06-29 2.81 Crystal Structure of a Variant Human Activation-induced Deoxycytidine Deaminase as an MBP fusion protein
4FED 2013-03-13 2.81 Crystal Structure of Htt36Q3H
6EG3 2018-10-31 2.84 Crystal structure of human BRM in complex with compound 15
6DD5 2018-10-17 2.85 Crystal Structure of the Cas6 Domain of Marinomonas mediterranea MMB-1 Cas6-RT-Cas1 Fusion Protein
5DIS 2015-11-04 2.85 Crystal structure of a CRM1-RanGTP-SPN1 export complex bound to a 113 amino acid FG-repeat containing fragment of Nup214
4QSZ 2015-07-08 2.86 Crystal structure of mouse JMJd7 fused with maltose-binding protein
1A7L 1998-06-17 2.9 DOMINANT B-CELL EPITOPE FROM THE PRES2 REGION OF HEPATITIS B VIRUS IN THE FORM OF AN INSERTED PEPTIDE SEGMENT IN MALTODEXTRIN-BINDING PROTEIN
5W0U 2017-08-16 2.9 Crystal structure of MBP fused activation-induced cytidine deaminase (AID) in complex with dCMP
4KHZ 2013-10-23 2.9 Crystal structure of the maltose-binding protein/maltose transporter complex in an pre-translocation conformation bound to maltoheptaose
5IIC 2017-06-14 2.9 Crystal structure of red abalone VERL repeat 3 at 2.9 A resolution
5WVM 2018-01-03 2.9 Crystal structure of baeS cocrystallized with 2 mM indole
3PUZ 2011-05-18 2.9 Crystal Structure of a pre-translocation state MBP-Maltose transporter complex bound to AMP-PNP
3D4C 2008-12-02 2.9 ZP-N domain of mammalian sperm receptor ZP3 (crystal form I)
5Z0V 2018-04-11 2.91 Structural insight into the Zika virus capsid encapsulating the viral genome
6I4Y 2019-03-20 2.91 X-ray structure of the human mitochondrial PRELID3b-TRIAP1 complex
6EG2 2018-10-31 2.98 Crystal structure of human BRM in complex with compound 16
5LEM 2017-08-02 2.98 Crystal structure of DARPin-DARPin rigid fusion, variant DD_Off7_11_3G124 in complex with Maltose-binding Protein and Green Fluorescent Protein
4FEC 2013-03-13 3.0 Crystal Structure of Htt36Q3H
5Y2G 2019-02-27 3.0 Structure of MBP tagged GBS CAMP
2ZXT 2009-08-04 3.0 Crystal structure of Tim40/MIA40, a disulfide relay system in mitochondria, solved as MBP fusion protein
6DBJ 2018-08-01 3.0 Cryo-EM structure of RAG in complex with 12-RSS and 23-RSS nicked DNA intermediates
4FE8 2013-03-13 3.0 Crystal Structure of Htt36Q3H-EX1-X1-C1(Alpha)
4BL8 2013-11-27 3.04 Crystal structure of full-length human Suppressor of fused (SUFU)
3SEV 2011-09-21 3.05 Zn-mediated Trimer of Maltose-binding Protein E310H/K314H by Synthetic Symmetrization
3PV0 2011-05-18 3.1 Crystal Structure of a pre-translocation state MBP-Maltose transporter complex without nucleotide
5LEL 2017-11-15 3.1 Crystal structure of DARPin-DARPin rigid fusion, variant DD_Off7_10_3G124 in complex with Maltose-binding Protein and Green Fluorescent Protein
3EF7 2008-12-02 3.1 ZP-N domain of mammalian sperm receptor ZP3 (crystal form III)
3PUY 2011-05-18 3.1 Crystal Structure of an outward-facing MBP-Maltose transporter complex bound to AMP-PNP after crystal soaking of the pretranslocation state
5JQE 2016-10-26 3.16 Crystal structure of caspase8 tDED
5W1C 2017-08-16 3.18 Crystal structure of MBP fused activation-induced cytidine deaminase (AID) in complex with cytidine
4WJV 2014-11-19 3.2 Crystal structure of Rsa4 in complex with the Nsa2 binding peptide
4WRN 2016-01-27 3.2 Crystal structure of the polymerization region of human uromodulin/Tamm-Horsfall protein
5FSG 2016-04-06 3.21 Structure of the hantavirus nucleoprotein provides insights into the mechanism of RNA encapsidation and a template for drug design
3L2J 2010-02-02 3.24 Dimeric structure of the ligand-free extracellular domain of the human parathyroid hormone receptor (PTH1R)
1T0K 2004-07-20 3.24 Joint X-ray and NMR Refinement of Yeast L30e-mRNA complex
4B3N 2012-10-24 3.3 Crystal structure of rhesus TRIM5alpha PRY/SPRY domain
6DBI 2018-08-01 3.4 Cryo-EM structure of RAG in complex with 12-RSS and 23-RSS nicked DNA intermediates
3EHT 2008-09-30 3.4 Crystal structure of the extracellular domain of human corticotropin releasing factor receptor type 1 (CRFR1) in complex with CRF
4PQK 2014-06-18 3.4 C-Terminal domain of DNA binding protein
4NDZ 2014-03-19 3.45 Structure of Maltose Binding Protein fusion to 2-O-Sulfotransferase with bound heptasaccharide and PAP
3IOW 2009-09-29 3.5 Huntingtin amino-terminal region with 17 Gln residues - crystal C99-Hg
4BLA 2013-11-27 3.5 Crystal structure of full-length human Suppressor of fused (SUFU) mutant lacking a regulatory subdomain (crystal form II)
3IOT 2009-09-29 3.5 Huntingtin amino-terminal region with 17 Gln residues - crystal C92-b
4XAJ 2015-03-04 3.55 Crystal structure of human NR2E1/TLX
4XZV 2016-01-20 3.58 Crystal Structure of SLMO1-TRIAP1 Complex
5GS2 2016-10-12 3.59 Crystal structure of diabody complex with repebody and MBP
3IOR 2009-09-29 3.6 Huntingtin amino-terminal region with 17 Gln residues - crystal C95
5W0Z 2017-08-16 3.61 Crystal structure of MBP fused activation-induced cytidine deaminase (AID)
3IO4 2009-10-27 3.63 Huntingtin amino-terminal region with 17 Gln residues - Crystal C90
3IOV 2009-09-29 3.7 Huntingtin amino-terminal region with 17 Gln residues - crystal C99
3IOU 2009-09-29 3.7 Huntingtin amino-terminal region with 17 Gln residues - crystal C94
3IO6 2009-10-27 3.7 Huntingtin amino-terminal region with 17 Gln residues - crystal C92-a
5CL1 2015-08-12 3.8 Complex structure of Norrin with human Frizzled 4
6DBU 2018-08-01 3.9 Cryo-EM structure of RAG in complex with 12-RSS and 23-RSS substrate DNAs
6BUZ 2017-12-20 3.92 Cryo-EM structure of CENP-A nucleosome in complex with kinetochore protein CENP-N
6DBR 2018-08-01 4.0 Cryo-EM structure of RAG in complex with one melted RSS and one unmelted RSS
6DBX 2018-08-01 4.2 Cryo-EM structure of RAG in complex with 12-RSS substrate DNA
6DBQ 2018-08-01 4.22 Cryo-EM structure of RAG in complex with 12-RSS and 23-RSS substrate DNAs
3J9P 2015-04-08 4.24 Structure of the TRPA1 ion channel determined by electron cryo-microscopy
6DBV 2018-08-01 4.29 Cryo-EM structure of RAG in complex with 12-RSS and 23-RSS substrate DNAs
6DBT 2018-08-01 4.3 Cryo-EM structure of RAG in complex with 12-RSS and 23-RSS substrate DNAs
6DBO 2018-08-01 4.4 Cryo-EM structure of RAG in complex with 12-RSS and 23-RSS substrate DNAs
5HZW 2017-06-07 4.45 Crystal structure of the orphan region of human endoglin/CD105 in complex with BMP9
6DBW 2018-08-01 4.7 Cryo-EM structure of RAG in complex with 12-RSS substrate DNA
6DBL 2018-08-01 5.0 Cryo-EM structure of RAG in complex with 12-RSS and 23-RSS substrate DNAs
5LDF 2016-08-10 6.2 Maltose binding protein genetically fused to dodecameric glutamine synthetase

Relevant UniProtKB Entries

Percent Identity Matching Chains Protein Accession Entry Name
90.7 Maltose-binding periplasmic protein P41130 MALE_PHOLU
93.9 Maltose-binding periplasmic protein P18815 MALE_KLEAE
94.3 Maltose-binding periplasmic protein P19576 MALE_SALTY
100.0 Maltose-binding periplasmic protein P0AEX9 MALE_ECOLI
100.0 Maltose-binding periplasmic protein P0AEY0 MALE_ECO57