Unfolding kinetics of bovine trypsinogen.


Abstract

The unfolding kinetics of bovine trypsinogen were studied by a fluorescence-detected stopped-flow technique at pH 5.8. Trypsinogen unfolding appeared to be a rather complex reaction. Two phases, fast (with a time constant in the millisecond range) and slow, were detected in the range 2-7 M guanidium chloride (GdmCl). The natural logarithm of the rate constant of the slow phase exhibited strong dependence on [GdmCl], changing from hundreds of seconds at low denaturant concentration to about 20 ms at 7 M GdmCl. The curvature of this dependence further suggests a complex mechanism of unfolding. Generally, similar kinetics were observed for the trypsinogen.Ca complex. Small differences could be noticed, however, for the fast phase. In agreement, Ca2+ influenced only this stage of the reaction. Analysis of the dependence of the time constant of the fast phase on [CaCl2] indicates that at 4 M GdmCl, trypsinogen.Ca unfolds about sixfold slower than free zymogen, and that native trypsinogen at 4 M GdmCl still exhibits high affinity for Ca2+. Limited data on trypsin unfolding show virtually an identical dependence of the slow phase on [GdmCl]; the fast phase, however was not observed. Moreover, in the 3-4.5 M GdmCl range, a separate phase was detected. It is postulated that this phase is a manifestation of the activation-domain unfolding. The Eyring plots for the fast phase of . trypsinogen and trypsinogen.Ca unfolding are linear, indicating little change in heat capacity for this stage of reaction. The slow step of unfolding, however, shows significant curvature which indicates a substantial increase in heat capacity. Study holds ProTherm entries: 9882 Extra Details: trypsinogen; unfolding kinetics; transition state;,denaturation; guanidinium chloride

Submission Details

ID: sBnWrZ8r

Submitter: Connie Wang

Submission Date: April 24, 2018, 8:39 p.m.

Version: 1

Publication Details
Otlewski J;Sywula A;Kolasinski M;Krowarsch D,Eur. J. Biochem. (1996) Unfolding kinetics of bovine trypsinogen. PMID:9022687
Additional Information

Structure view and single mutant data analysis

Study data

No weblogo for data of varying length.
Colors: D E R H K S T N Q A V I L M F Y W C G P
 

Data Distribution

Studies with similar sequences (approximate matches)

Correlation with other assays (exact sequence matches)


Relevant PDB Entries

Structure ID Release Date Resolution Structure Title
5MOS 2018-02-28 Joint X-ray/neutron structure of cationic trypsin in complex with N-amidinopiperidine
5MON 2017-05-24 Joint X-ray/neutron structure of cationic trypsin in complex with 2-aminopyridine
5MOP 2018-01-17 Joint X-ray/neutron structure of cationic trypsin in its apo form
5MOO 2017-05-24 Joint X-ray/neutron structure of cationic trypsin in complex with aniline
5MOR 2018-02-28 Joint X-ray/neutron structure of cationic trypsin in complex with benzylamine
5MOQ 2018-02-28 Joint X-ray/neutron structure of cationic trypsin in complex with benzamidine
3OTJ 2011-01-26 A Crystal Structure of Trypsin Complexed with BPTI (Bovine Pancreatic Trypsin Inhibitor) by X-ray/Neutron Joint Refinement
4I8H 2012-12-19 0.75 Bovine trypsin at 0.75 resolution
5MN1 2017-05-24 0.79 Cationic trypsin in complex with 2-aminopyridine (deuterated sample at 100 K)
4I8G 2012-12-19 0.8 Bovine trypsin at 0.8 resolution
3MI4 2010-04-28 0.8 Bovine trypsin at 0.8 A resolution, non-restrained refinement
3MFJ 2010-04-21 0.8 Bovine trypsin at 0.8 A resolution, restrained refinement
5MNK 2018-01-17 0.8 Cationic trypsin in complex with benzylamine (deuterated sample at 100 K)
4I8K 2012-12-19 0.85 Bovine trypsin at 0.85 resolution
5MNN 2018-01-17 0.86 Cationic trypsin in complex with N-amidinopiperidine (deuterated sample at 100 K)
5MNG 2018-01-17 0.86 Cationic trypsin in complex with benzamidine (deuterated sample at 100 K)
4I8L 2012-12-19 0.87 Bovine trypsin at 0.87 resolution
4I8J 2012-12-19 0.87 Bovine trypsin at 0.87 A resolution
4XOJ 2015-08-12 0.91 Structure of bovine trypsin in complex with analogues of sunflower inhibitor 1 (SFTI-1)
5MNC 2017-05-24 0.92 Cationic trypsin in complex with aniline (deuterated sample at 100 K)
2XTT 2010-11-10 0.93 Bovine trypsin in complex with evolutionary enhanced Schistocerca gregaria protease inhibitor 1 (SGPI-1-P02)
5MNH 2018-01-17 0.93 Cationic trypsin in complex with benzamidine (deuterated sample at 295 K)
5MNB 2017-05-24 0.94 Cationic trypsin in complex with 2-aminopyridine (deuterated sample at 295 K)
1HJ9 2002-01-04 0.95 Atomic resolution structures of trypsin provide insight into structural radiation damage
5MNO 2018-01-17 0.96 Cationic trypsin in complex with N-amidinopiperidine (deuterated sample at 295 K)
2AYW 2006-01-17 0.97 Crystal Structure of the complex formed between trypsin and a designed synthetic highly potent inhibitor in the presence of benzamidine at 0.97 A resolution
5MNM 2018-01-17 0.98 Cationic trypsin in complex with benzylamine (at 295 K)
5MNF 2018-01-17 0.99 Cationic trypsin in its apo form (deuterated sample at 295 K)
4NIV 2014-02-19 1.0 Crystal structure of trypsiligase (K60E/N143H/Y151H/D189K trypsin) trigonal form
4U2W 2015-01-14 1.0 Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin
5MNP 2018-01-17 1.01 Cationic trypsin in complex with N-amidinopiperidine (at 295 K)
5MNE 2018-01-17 1.01 Cationic trypsin in its apo form (deuterated sample at 100 K)
1S0R 2005-01-18 1.02 Bovine Pancreatic Trypsin inhibited with Benzamidine at Atomic resolution
1S0Q 2005-01-18 1.02 Native Bovine Pancreatic Trypsin
5MNL 2018-01-17 1.04 Cationic trypsin in complex with benzylamine (deuterated sample at 295 K)
5F6M 2016-01-06 1.1 Isotropic Trypsin Model for Comparison of Diffuse Scattering
5LGO 2016-08-10 1.12 Trypsin inhibitors for the treatment of pancreatitis - cpd 15
3NKK 2010-11-10 1.12 Trypsin in complex with fluorine containing fragment
2AH4 2006-05-16 1.13 guanidinobenzoyl-trypsin acyl-enzyme at 1.13 A resolution
2AGI 2006-05-16 1.14 The leupeptin-trypsin covalent complex at 1.14 A resolution
1UTN 2004-01-09 1.15 Trypsin specificity as elucidated by LIE calculations, X-ray structures and association constant measurements
2AGE 2006-05-16 1.15 Succinyl-AAPR-trypsin acyl-enzyme at 1.15 A resolution
2UUY 2007-04-10 1.15 Structure of a tick tryptase inhibitor in complex with bovine trypsin
3NK8 2010-11-10 1.15 Trypsin in complex with fluorine-containing fragment
1UTQ 2004-01-15 1.15 Trypsin specificity as elucidated by LIE calculations, X-ray structures and association constant measurements
1UTO 2004-01-15 1.15 Trypsin specificity as elucidated by LIE calculations, X-ray structures and association constant measurements
6EAT 2019-03-13 1.15 Crystallographic structure of the cyclic nonapeptide derived from the BTCI inhibitor bound to beta-trypsin in space group P 21 21 21.
6EAU 2019-08-07 1.18 Crystallographic structure of the octapeptide derived from the BTCI inhibitor bound to beta-trypsin in space group P 21 21 21.
3PLB 2011-12-07 1.18 Bovine trypsin variant X(tripleIle227) in complex with small molecule inhibitor
6EAX 2019-08-07 1.19 Crystallographic structure of the cyclic hexapeptide derived from the BTCI inhibitor bound to beta-trypsin in space group P 21 21 21
3UNR 2012-06-27 1.2 Bond length analysis of asp, glu and his residues in trypsin at 1.2A resolution
4AB9 2012-02-08 1.2 Fragments bound to bovine trypsin for the SAMPL challenge
4YTA 2015-05-27 1.2 BOND LENGTH ANALYSIS OF ASP, GLU AND HIS RESIDUES IN TRYPSIN AT 1.2A RESOLUTION
2BLW 2005-09-07 1.2 Trypsin after a high dose X-ray 'Burn'
1Y59 2005-12-13 1.2 Dianhydrosugar-based benzamidine, factor Xa specific inhibitor in complex with bovine trypsin mutant
2BLV 2005-09-07 1.2 Trypsin before a high dose x-ray 'burn'
1J8A 2001-09-12 1.21 CRYSTAL STRUCTURE OF BENZAMIDINE INHIBITED BOVINE PANCREATIC TRYPSIN AT 105K TO 1.21A RESOLUTION FROM LABORATORY SOURCE WITH HIGH NUMBER OF WATERS MODELLED
4MTB 2014-12-24 1.22 Bovine trypsin in complex with small molecule inhibitor
4ABD 2012-02-08 1.25 Fragments bound to bovine trypsin for the SAMPL challenge
4Y0Y 2015-06-24 1.25 Trypsin in complex with with BPTI
4ABA 2012-02-08 1.25 Fragments bound to bovine trypsin for the SAMPL challenge
4ABB 2012-02-08 1.25 Fragments bound to bovine trypsin for the SAMPL challenge
4ABH 2012-02-08 1.25 Fragments bound to bovine trypsin for the SAMPL challenge
2AGG 2006-05-16 1.28 succinyl-AAPK-trypsin acyl-enzyme at 1.28 A resolution
6EAW 2019-08-07 1.29 Crystallographic structure of the cyclic heptapeptide derived from the BTCI inhibitor bound to beta-trypsin in space group P 21 21 21
4HGC 2013-10-09 1.29 Crystal structure of bovine trypsin complexed with sfti-1 analog containing a peptoid residue at position p1
6BFP 2018-10-31 1.29 Bovine trypsin bound to potent inhibitor
2BY9 2006-02-06 1.3 Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection
4KTS 2014-04-02 1.3 Bovine trypsin in complex with microviridin J at pH 8.5
2BY7 2006-02-06 1.3 Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection
4Y11 2015-06-24 1.3 Trypsin in complex with with BPTI mutant (2S)-2-amino-4,4,4-trifluorobutanoic acid
2BY6 2006-02-06 1.3 Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection
4TPY 2014-10-22 1.3 High throughput screening using acoustic droplet ejection to combine protein crystals and chemical libraries on crystallization plates at high density
2BY5 2006-02-06 1.3 Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection
1UTP 2004-01-15 1.3 Trypsin specificity as elucidated by LIE calculations, X-ray structures and association constant measurements
4ABE 2012-02-08 1.3 Fragments bound to bovine trypsin for the SAMPL challenge
2BYA 2006-02-06 1.3 Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection
4ABF 2012-02-08 1.3 Fragments bound to bovine trypsin for the SAMPL challenge
4NIX 2014-02-19 1.3 Crystal structure of trypsiligase (K60E/N143H/Y151H/D189K trypsin) orthorhombic form, zinc-bound
2BY8 2006-02-06 1.3 Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection
4NIW 2014-02-19 1.31 Crystal structure of trypsiligase (K60E/N143H/Y151H/D189K trypsin) orthorhombic form
5EG4 2016-07-13 1.32 BOVINE TRYPSIN IN COMPLEX WITH CYCLIC INHIBITOR
6DWR 2019-07-03 1.32 Trypsin serine protease modified with the protease inhibitor cyanobenzylsulfonylfluoride
2OXS 2007-03-13 1.32 Crystal Structure of the trypsin complex with benzamidine at high temperature (35 C)
1O3D 2003-09-02 1.33 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
5PTP 1997-07-07 1.34 STRUCTURE OF HYDROLASE (SERINE PROTEINASE)
5MNQ 2018-01-17 1.34 Cationic trypsin in complex with a derivative of N-amidinopiperidine
4KTU 2014-04-02 1.35 Bovine trypsin in complex with microviridin J at pH 6.5
1P2J 2004-04-20 1.35 Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin
1C5S 2000-12-22 1.36 STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
4B2B 2012-08-01 1.36 Structure of the factor Xa-like trypsin variant triple-Ala (TGPA) in complex with eglin C
4Y0Z 2015-06-24 1.37 Trypsin in complex with with BPTI mutant AMINOBUTYRIC ACID
1C5T 2000-12-22 1.37 STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
5LH4 2018-01-17 1.37 Trypsin inhibitors for the treatment of pancreatitis - cpd 1
1C5U 2000-12-22 1.37 STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
1GI4 2002-01-22 1.37 A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
1C1Q 2000-07-26 1.37 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1C1P 2000-07-26 1.37 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1C1T 2000-07-26 1.37 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
4Y10 2015-06-24 1.37 Trypsin in complex with with BPTI mutant (2S)-2-amino-4,4-difluorobutanoic acid
1C1R 2000-07-26 1.37 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1O38 2003-09-02 1.38 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1GI2 2002-01-22 1.38 A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
1O2W 2003-09-02 1.38 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
6EAV 2019-08-07 1.39 Crystallographic structure of the cyclic heptapeptide derived from the BTCI inhibitor bound to beta-trypsin in space group P 4(1) 2(1) 2
1GHZ 2002-01-22 1.39 A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
3A8A 2010-09-29 1.4 Crystal Structure of Trypsin complexed with 4-formylbenzimidamide and aniline
1N6Y 2003-03-04 1.4 RIP-phasing on Bovine Trypsin
2ZQ2 2009-08-04 1.4 Exploring trypsin S3 pocket
1N6X 2003-03-04 1.4 RIP-phasing on Bovine Trypsin
1C2J 2000-07-26 1.4 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1C2H 2000-07-26 1.4 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1C2M 2000-07-26 1.4 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1O3J 2003-09-02 1.4 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1O3L 2003-09-02 1.4 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1C1O 2000-07-26 1.4 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1C1N 2000-07-26 1.4 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1TPP 1983-01-18 1.4 THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS
1Y5A 2005-12-13 1.4 Dianhydrosugar-based benzamidine, factor Xa specific inhibitor in complex with bovine trypsin mutant
2G8T 2006-09-05 1.41 Indole-amidine Complexes with Bovine Trypsin
1O2U 2003-09-02 1.41 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1O35 2003-09-02 1.41 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
4NCY 2014-04-09 1.42 In situ trypsin crystallized on a MiTeGen micromesh with imidazole ligand
5MNX 2017-05-24 1.42 Neutron structure of cationic trypsin in complex with 2-aminopyridine
1GI0 2002-01-22 1.42 A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
1GI1 2002-01-22 1.42 A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
4B2C 2012-08-01 1.43 Structure of the factor Xa-like trypsin variant triple-Ala (TPA) in complex with eglin C
1C5P 2000-12-22 1.43 STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
3UWI 2012-12-05 1.43 Bovine trypsin variant X(tripleGlu217Phe227) in complex with small molecule inhibitor
1O3K 2003-09-02 1.43 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
5MNY 2017-05-24 1.43 Neutron structure of cationic trypsin in complex with aniline
1C5Q 2000-12-22 1.43 STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
1GI3 2002-01-22 1.44 A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
5MNA 2017-05-24 1.44 Cationic trypsin in complex with aniline (deuterated sample at 295 K)
3PMJ 2011-11-23 1.45 Bovine trypsin variant X(tripleIle227) in complex with small molecule inhibitor
1O2Y 2003-09-02 1.45 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1O2R 2003-09-02 1.45 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
4ABJ 2012-03-07 1.45 Co-complex structure of bovine trypsin with a modified Bowman-Birk inhibitor (IcA)SFTI-1(1,14), that was 1,5-disubstituted with 1,2,3- trizol to mimic a cis amide bond
1O37 2003-09-02 1.45 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
2G5V 2006-08-29 1.45 Indole-amidine Complexes with Bovine Trypsin
5MNZ 2018-01-17 1.45 Neutron structure of cationic trypsin in its apo form
1O2X 2003-09-02 1.46 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1O33 2003-09-02 1.46 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1C5R 2000-12-22 1.47 STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
1O2P 2003-05-13 1.47 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1C2I 2000-07-26 1.47 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1C5V 2000-12-22 1.48 STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
1GI6 2002-01-22 1.49 A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
5MO1 2018-02-28 1.49 Neutron structure of cationic trypsin in complex with benzylamine
1O2N 2003-05-13 1.5 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1TLD 1990-01-15 1.5 CRYSTAL STRUCTURE OF BOVINE BETA-TRYPSIN AT 1.5 ANGSTROMS RESOLUTION IN A CRYSTAL FORM WITH LOW MOLECULAR PACKING DENSITY. ACTIVE SITE GEOMETRY, ION PAIRS AND SOLVENT STRUCTURE
1GJ6 2002-04-27 1.5 ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS
5MO2 2018-02-28 1.5 Neutron structure of cationic trypsin in complex with N-amidinopiperidine
5MO0 2018-02-28 1.5 Neutron structure of cationic trypsin in complex with benzamidine
2J9N 2007-04-03 1.5 Robotically harvested Trypsin complexed with Benzamidine containing polypeptide mediated crystal contacts
1BTY 1995-10-15 1.5 Crystal structure of beta-trypsin in complex with benzamidine
1O2I 2003-05-13 1.5 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1O2Q 2003-09-02 1.5 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1C2L 2000-07-26 1.5 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1XUI 1998-11-11 1.5 TRYPSIN-KETO-BABIM, ZN+2-FREE, PH 8.2
2BTC 2000-01-19 1.5 BOVINE TRYPSIN IN COMPLEX WITH SQUASH SEED INHIBITOR (CUCURBITA PEPO TRYPSIN INHIBITOR II)
1XUG 1998-12-16 1.5 TRYPSIN-BABIM-ZN+2, PH 8.2
1O2V 2003-09-02 1.5 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
3LJO 2010-10-06 1.5 Bovine trypsin in complex with UB-THR 11
1O34 2003-09-02 1.5 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1O3I 2003-09-02 1.51 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
2G5N 2006-08-29 1.51 Indole-amidine Complexes with Bovine Trypsin
2ZFS 2009-01-13 1.51 Exploring trypsin S3 pocket
4ABG 2012-02-08 1.52 Fragments bound to bovine trypsin for the SAMPL challenge
1O3H 2003-09-02 1.53 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
3PM3 2011-12-07 1.53 Bovine trypsin variant X(tripleIle227) in complex with small molecule inhibitor
3PLK 2011-12-07 1.53 Bovine trypsin variant X(tripleIle227) in complex with small molecule inhibitor
5LH8 2016-08-10 1.54 Trypsin inhibitors for the treatment of pancreatitis - cpd 8
3UPE 2012-11-21 1.54 Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor
3GY4 2010-03-23 1.55 A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC
3LJJ 2010-10-06 1.55 Bovine trypsin in complex with UB-THR 10
2G81 2007-01-02 1.55 Crystal Structure of the Bowman-Birk Inhibitor from Vigna unguiculata Seeds in Complex with Beta-trypsin at 1.55 Angstrons Resolution
3ITI 2009-10-27 1.55 Structure of bovine trypsin with the MAD triangle B3C
1O3O 2003-09-02 1.55 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
3GY7 2010-03-23 1.55 A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC
5T3H 2016-11-30 1.55 bovine trypsin soaked with selenourea for 5 min
1O3M 2003-09-02 1.55 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1O3N 2003-09-02 1.55 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
2PTN 1982-03-04 1.55 ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY
1O3G 2003-09-02 1.55 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
4ABI 2012-03-07 1.55 Co-complex structure of bovine trypsin with a modified Bowman-Birk inhibitor (PtA)SFTI-1(1,14), that was 1,4-disubstituted with a 1,2,3- trizol to mimic a trans amide bond
1O30 2003-09-02 1.55 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1O3F 2003-09-02 1.55 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
2PLX 2007-08-07 1.56 Trypsin complexed to a synthetic peptide from Veronica hederifolia
2OTV 2007-02-27 1.56 Crystal structure of the complex formed between bovine trypsin and nicotinamide at 1.56 A resolution
3GY2 2010-03-23 1.57 A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC
2FX6 2006-02-14 1.57 bovine trypsin complexed with 2-aminobenzamidazole
3GY5 2010-03-23 1.57 A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC
2FI4 2006-01-24 1.58 Crystal structure of a BPTI variant (Cys14->Ser) in complex with trypsin
2FI3 2006-01-24 1.58 Crystal structure of a BPTI variant (Cys14->Ser, Cys38->Ser) in complex with trypsin
2FI5 2006-01-24 1.58 Crystal structure of a BPTI variant (Cys38->Ser) in complex with trypsin
1O39 2003-09-02 1.59 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1Y5U 2005-12-13 1.6 Dianhydrosugar-based benzamidine, factor Xa specific inhibitor in complex with bovine trypsin mutant
3RXP 2011-08-24 1.6 Crystal structure of Trypsin complexed with (1,5-dimethylpyrazol-3-yl)methanamine
3RXO 2011-08-24 1.6 Crystal structure of Trypsin complexed with (3-pyrrol-1-ylphenyl)methanamine
1P2K 2004-04-20 1.6 Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin
3RXI 2011-08-24 1.6 Crystal structure of Trypsin complexed with 2-(1H-indol-3-yl)ethanamine
3RXK 2011-08-24 1.6 Crystal structure of Trypsin complexed with methyl 4-amino-1-methyl-pyrrolidine-2-carboxylate
1V2L 2004-06-01 1.6 Benzamidine in complex with bovine trypsin variant X(triple.Glu)bT.D1
1GI5 2002-01-22 1.6 A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
3PWC 2011-12-21 1.6 Bovine trypsin variant X(tripleGlu217Ile227) in complex with small molecule inhibitor
1Y3V 2005-12-06 1.6 Trypsin Inhibitor Complex
4AB8 2012-02-08 1.6 Fragments bound to bovine trypsin for the SAMPL challenge
6E5M 2019-03-13 1.61 Crystallographic structure of the cyclic nonapeptide derived from the BTCI inhibitor bound to beta-trypsin in space group P 32 2 1
1V2O 2004-06-01 1.62 Trypsin inhibitor in complex with bovine trypsin variant X(SSYI)bT.B4
3UNQ 2012-11-21 1.62 Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor
1O2T 2003-09-02 1.62 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
2FTL 2006-02-14 1.62 Crystal structure of trypsin complexed with BPTI at 100K
1C1S 2000-07-26 1.63 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1O2O 2003-05-13 1.63 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
3V13 2012-12-12 1.63 Bovine trypsin variant X(tripleGlu217Phe227) in complex with small molecule inhibitor
3PWB 2011-12-21 1.63 Bovine trypsin variant X(tripleGlu217Ile227) in complex with small molecule inhibitor
1O2K 2003-05-13 1.63 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
3PLP 2011-12-07 1.63 Bovine trypsin variant X(tripleIle227) in complex with small molecule inhibitor
1O3E 2003-09-02 1.64 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
3D65 2009-06-16 1.64 Crystal structure of Textilinin-1, a Kunitz-type serine protease inhibitor from the Australian Common Brown snake venom, in complex with trypsin
1O3C 2003-09-02 1.64 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1O2J 2003-05-13 1.65 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1C2K 2000-07-26 1.65 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1V2M 2004-06-01 1.65 Benzamidine in complex with bovine trypsin variant X(triple.Glu)bT.A1
2FX4 2006-02-14 1.65 Bovine trypsin bound by 4-piperidinebutyrate to make acylenzyme complex
2FTM 2006-02-14 1.65 Crystal structure of trypsin complexed with the BPTI variant (Tyr35->Gly)
1TGN 1979-10-19 1.65 STRUCTURE OF BOVINE TRYPSINOGEN AT 1.9 ANGSTROMS RESOLUTION
1O2Z 2003-09-02 1.65 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1O2S 2003-09-02 1.65 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1P2I 2004-04-20 1.65 Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin
1C2D 2000-07-26 1.65 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1SFI 1999-07-09 1.65 High resolution structure of a potent, cyclic protease inhibitor from sunflower seeds
1C2G 2000-07-26 1.65 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1C2E 2000-07-26 1.65 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1Y5B 2005-12-13 1.65 Dianhydrosugar-based benzamidine, factor Xa specific inhibitor in complex with bovine trypsin mutant
1O31 2003-09-02 1.66 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
2ZDK 2008-10-14 1.67 Exploring Trypsin S3 Pocket
3RU4 2012-08-29 1.68 Crystal structure of the Bowman-Birk serine protease inhibitor BTCI in complex with trypsin and chymotrypsin
3RXQ 2011-08-24 1.68 Crystal structure of Trypsin complexed with benzamide (F01 and F05, cocktail experiment)
3RXU 2011-08-24 1.68 Crystal structure of Trypsin complexed with benzamide (F05 and A06, cocktail experiment)
1O2L 2003-05-13 1.68 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
2ZQ1 2009-08-04 1.68 Exploring trypsin S3 pocket
3UOP 2012-11-21 1.69 Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor
1O2M 2003-05-13 1.69 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1BTW 1995-10-15 1.7 Episelection: novel KI ~nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface
3PTN 1982-03-04 1.7 ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY
3RXC 2011-08-24 1.7 Crystal structure of Trypsin complexed with 2-aminopyridine
3RXB 2011-08-24 1.7 Crystal structure of Trypsin complexed with 4-guanidinobutanoic acid
3PTB 1983-01-18 1.7 THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS
3RXA 2011-08-24 1.7 Crystal structure of Trypsin complexed with cycloheptanamine
3RXV 2011-08-24 1.7 Crystal structure of Trypsin complexed with benzamide (F05 and F03, cocktail experiment)
3GY3 2010-03-23 1.7 A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC
1V2R 2004-06-01 1.7 Trypsin inhibitor in complex with bovine trypsin variant X(SSRI)bT.B4
3RXF 2011-08-24 1.7 Crystal structure of Trypsin complexed with 4-aminopyridine
4AOR 2013-01-09 1.7 Cationic trypsin in complex with the Spinacia oleracea trypsin inhibitor III (SOTI-III)
3RXT 2011-08-24 1.7 Crystal structure of Trypsin complexed with (3-methoxyphenyl)methanamin (F04 and F03, cocktail experiment)
3M7Q 2011-03-16 1.7 Crystal structure of recombinant Kunitz Type serine protease Inhibitor-1 from the Caribbean sea anemone stichodactyla helianthus in complex with bovine pancreatic trypsin
2TGT 1982-03-04 1.7 ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY
3RXJ 2011-08-24 1.7 Crystal structure of Trypsin complexed with 4-guanidinobenzoic acid
5K7R 2017-04-05 1.7 MicroED structure of trypsin at 1.7 A resolution
1RXP 2004-06-08 1.7 STRUCTURE OF TRYPSIN (ORTHORHOMBIC) WITH 1-(4-TERT-BUTYLCARBAMOYL- PIPERAZINE-1-CARBONYL)-3-(3-GUANIDINO-PROPYL)-4-OXO-AZETIDINE-2-CARBOXYLIC ACID
1BTX 1995-10-15 1.7 Episelection: Novel Ki ~Nanomolar Inhibitors of Serine Proteases Selected by Binding or Chemistry on an Enzyme Surface
1O36 2003-09-02 1.7 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
2O9Q 2007-12-25 1.7 The crystal structure of Bovine Trypsin complexed with a small inhibition peptide ORB2K
3RXL 2011-08-24 1.7 Crystal structure of Trypsin complexed with (2,5-dimethyl-3-furyl)methanamine
1TPO 1983-01-18 1.7 THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS
3RXH 2011-08-24 1.7 Crystal structure of Trypsin complexed with 2-(1H-imidazol-4-yl)ethanamine
1TGT 1982-03-04 1.7 ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY
3RXM 2011-08-24 1.7 Crystal structure of Trypsin complexed with [2-(2-thienyl)thiazol-4-yl]methanamine
3RXD 2011-08-24 1.7 Crystal structure of Trypsin complexed with (3-methoxyphenyl)methanamine
1JRT 1996-10-14 1.7 HEMIACETAL COMPLEX BETWEEN LEUPEPTIN AND TRYPSIN
1C2F 2000-07-26 1.7 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
3GY6 2010-03-23 1.7 A comparative study on the inhibition of bovine beta-trypsin by the bis-benzamidines diminazene and pentamidine
1Y3X 2005-12-06 1.7 TRYPSIN INHIBITOR COMPLEX
1TX8 2005-10-18 1.7 Bovine Trypsin complexed with AMSO
3T26 2011-12-28 1.7 Orthorhombic trypsin (bovine) in the presence of sarcosine
3AAV 2010-04-07 1.7 Bovine beta-trypsin bound to meta-diamidino schiff base copper (II) chelate
3Q00 2011-12-21 1.7 Bovine trypsin variant X(tripleGlu217Ile227) in complex with small molecule inhibitor
3T25 2011-12-28 1.7 TMAO-grown orthorhombic trypsin (bovine)
3RXE 2011-08-24 1.7 Crystal structure of Trypsin complexed with benzamide
3RXG 2011-08-24 1.7 Crystal structure of Trypsin complexed with 4-aminocyclohexanol
3ATI 2011-08-24 1.71 Crystal structure of trypsin complexed with (3-methoxyphenyl)methanamine
3RXR 2011-08-24 1.72 Crystal structure of Trypsin complexed with cycloheptanamine (F01 and F03, cocktail experiment)
1V2S 2004-06-01 1.72 Benzamidine in complex with bovine trypsin variant X(SSFI.Glu)bT.D1
3ATM 2011-08-24 1.72 Crystal structure of trypsin complexed with 2-(1H-indol-3-yl)ethanamine
3ATK 2011-08-24 1.74 Crystal structure of trypsin complexed with cycloheptanamine
3ATL 2011-08-24 1.74 Crystal structure of trypsin complexed with benzamidine
3RXS 2011-08-24 1.74 Crystal structure of Trypsin complexed with (3-methoxyphenyl)methanamine (F04 and A06, cocktail experiment)
1Y3Y 2005-12-06 1.75 TRYPSIN INHIBITOR COMPLEX
3A87 2010-09-29 1.75 Crystal Structure of Trypsin complexed with (E)-4-((2-nicotinoylhydrazono)methyl)benzimidamide (soaking 5 minutes)
3GY8 2010-03-23 1.75 A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC
3A7T 2010-09-29 1.75 Crystal Structure of Trypsin complexed with 4-formylbenzimidamide
3A85 2010-09-29 1.75 Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid (soaking 15 seconds)
3A84 2010-09-29 1.75 Crystal Structure of Trypsin complexed with(E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid (soaking 5 seconds)
1V2W 2004-06-01 1.75 Trypsin inhibitor in complex with bovine trypsin variant X(SSAI)bT.B4
1O3B 2003-09-02 1.75 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
3A7X 2010-09-29 1.75 Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid (soaking 45seconds)
3T29 2011-12-28 1.75 TMAO-grown trigonal trypsin (bovine)
3A86 2010-09-29 1.75 Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid (soaking 30 seconds)
3BTH 2000-03-13 1.75 THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
3A82 2010-09-29 1.75 Crystal Structure of Trypsin complexed with pre-synthesized (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid
3A80 2010-09-29 1.75 Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)-2-methylpropanoic acid (soaking 40seconds)
3A8B 2010-09-29 1.75 Crystal Structure of Trypsin complexed with (E)-4-((4-bromophenylimino)methyl)benzimidamide
3AAS 2010-04-07 1.75 Bovine beta-trypsin bound to meta-guanidino schiff base copper (II) chelate
1TX7 2005-09-20 1.75 Bovine Trypsin complexed with p-amidinophenylmethylphosphinic acid (AMPA)
3A7W 2010-09-29 1.75 Crystal Structure of Trypsin complexed with (E)-4-((tetrahydro-2H-pyran-2-yloxyimino)methyl)benzimidamide (soaking 4hours)
3A8D 2010-09-29 1.75 Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid (under aniline-free condition)
3A7V 2010-09-29 1.75 Crystal Structure of Trypsin complexed with 3-formylbenzimidamide
3A88 2010-09-29 1.75 Crystal Structure of Trypsin complexed with (E)-4-((2-nicotinoylhydrazono)methyl)benzimidamide (soaking 30 minutes)
2ZFT 2009-01-13 1.76 Exploring trypsin S3 pocket
1O2H 2003-05-13 1.77 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
5FXL 2016-03-16 1.78 Structure of trypsin solved by MR from data collected by Direct Data Collection (DDC) using the ESRF RoboDiff goniometer
3A83 2010-09-29 1.78 Crystal Structure of Trypsin complexed with pre-synthesized (E)-4-((2-nicotinoylhydrazono)methyl)benzimidamide
4B1T 2012-08-01 1.78 Structure of the factor Xa-like trypsin variant triple-Ala (TA) in complex with eglin C
3A81 2010-09-29 1.78 Crystal Structure of Trypsin complexed with (E)-4-((2-nicotinoylhydrazono)methyl)benzimidamide (soaking 8 hours)
1O32 2003-09-02 1.78 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1F2S 2000-06-05 1.79 CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN BOVINE BETA-TRYPSIN AND MCTI-A, A TRYPSIN INHIBITOR OF SQUASH FAMILY AT 1.8 A RESOLUTION
1V2V 2004-06-01 1.8 Benzamidine in complex with bovine trypsin variant X(SSAI)bT.C1
1JRS 1996-10-14 1.8 HEMIACETAL COMPLEX BETWEEN LEUPEPTIN AND TRYPSIN
1TAW 1997-06-24 1.8 BOVINE TRYPSIN COMPLEXED TO APPI
3A7Z 2010-09-29 1.8 Crystal Structure of Trypsin complexed with (E)-4-((1-methylpiperidin-4-yloxyimino)methyl)benzimidamide (soaking 3hours)
1G3E 2001-01-17 1.8 BOVINE BETA-TRYPSIN BOUND TO PARA-AMIDINO SCHIFF-BASE COPPER (II) CHELATE
1QBN 2000-05-03 1.8 Bovine Trypsin 2-[amino(imino)methyl]-2-hydroxyphenoxy]-6-[3-(4,5-dihydro-1H-imidazol-2-yl)phenoxy]pyridine-4-carboxylic Acid (ZK-806688) Complex
1TGS 1983-01-18 1.8 THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX BETWEEN PANCREATIC SECRETORY INHIBITOR (KAZAL TYPE) AND TRYPSINOGEN AT 1.8 ANGSTROMS RESOLUTION. STRUCTURE SOLUTION, CRYSTALLOGRAPHIC REFINEMENT AND PRELIMINARY STRUCTURAL INTERPRETATION
1QBO 2000-05-03 1.8 BOVINE TRYPSIN 7-[[6-[[1-(1-IMINOETHYL)PIPERIDIN-4-YL]OXY]-2-METHYL-BENZIMIDAZOL-1-YL]METHYL]NAPHTHALENE-2-CARBOXIMIDAMID ZK-806711 INHIBITOR COMPLEX
1BJV 1998-12-02 1.8 BETA-TRYPSIN COMPLEXED WITH APPU
1XUK 1998-11-11 1.8 TRYPSIN-BABIM-SULFATE, PH 5.9
1Y3W 2005-12-06 1.8 TRYPSIN INHIBITOR COMPLEX
1QA0 2000-04-10 1.8 BOVINE TRYPSIN 2-AMINOBENZIMIDAZOLE COMPLEX
3A89 2010-09-29 1.8 Crystal Structure of Trypsin complexed with (E)-4-((2-nicotinoylhydrazono)methyl)benzimidamide (soaking 4 hours)
1TNG 1994-11-30 1.8 PREDICTION OF NOVEL SERINE PROTEASE INHIBITORS
1MAY 1996-10-14 1.8 BETA-TRYPSIN PHOSPHONATE INHIBITED
1G3C 2001-01-17 1.8 BOVINE BETA-TRYPSIN BOUND TO PARA-AMIDINO SCHIFF BASE IRON(III) CHELATE
1NTP 1988-01-16 1.8 USE OF THE NEUTRON DIFFRACTION H/D EXCHANGE TECHNIQUE TO DETERMINE THE CONFORMATIONAL DYNAMICS OF TRYPSIN
1SBW 1999-05-06 1.8 CRYSTAL STRUCTURE OF MUNG BEAN INHIBITOR LYSINE ACTIVE FRAGMENT COMPLEX WITH BOVINE BETA-TRYPSIN AT 1.8A RESOLUTION
1BJU 1998-12-02 1.8 BETA-TRYPSIN COMPLEXED WITH ACPU
1V2N 2004-06-01 1.8 Potent factor XA inhibitor in complex with bovine trypsin variant X(99/175/190)bT
1QB6 2000-04-29 1.8 BOVINE TRYPSIN 3,3'-[3,5-DIFLUORO-4-METHYL-2, 6-PYRIDINEDIYLBIS(OXY)]BIS(BENZENECARBOXIMIDAMIDE) (ZK-805623) COMPLEX
1PPC 1994-01-31 1.8 GEOMETRY OF BINDING OF THE BENZAMIDINE-AND ARGININE-BASED INHIBITORS N-ALPHA-(2-NAPHTHYL-SULPHONYL-GLYCYL)-DL-P-AMIDINOPHENYLALANYL-PIPERIDINE (NAPAP) AND (2R,4R)-4-METHYL-1-[N-ALPHA-(3-METHYL-1,2,3,4-TETRAHYDRO-8-QUINOLINESULPHONYL)-L-ARGINYL]-2-PIPERIDINE CARBOXYLIC ACID (MQPA) TO HUMAN ALPHA-THROMBIN: X-RAY CRYSTALLOGRAPHIC DETERMINATION OF THE NAPAP-TRYPSIN COMPLEX AND MODELING OF NAPAP-THROMBIN AND MQPA-THROMBIN
1ZR0 2005-06-07 1.8 Crystal Structure of Kunitz Domain 1 of Tissue Factor Pathway Inhibitor-2 with Bovine Trypsin
3V12 2012-12-12 1.8 Bovine trypsin variant X(tripleGlu217Phe227) in complex with small molecule inhibitor
1TGB 1979-06-13 1.8 CRYSTAL STRUCTURE OF BOVINE TRYPSINOGEN AT 1.8 ANGSTROMS RESOLUTION. II. CRYSTALLOGRAPHIC REFINEMENT, REFINED CRYSTAL STRUCTURE AND COMPARISON WITH BOVINE TRYPSIN
1TGC 1982-03-04 1.8 ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY
1AZ8 1999-01-13 1.8 BOVINE TRYPSIN COMPLEXED TO BIS-PHENYLAMIDINE INHIBITOR
3BTM 2000-03-13 1.8 THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
1TNH 1994-11-30 1.8 PREDICTION OF NOVEL SERINE PROTEASE INHIBITORS
1QB9 2000-04-30 1.8 BOVINE TRYPSIN 7-[[2-[[1-(1-IMINOETHYL)PIPERIDIN-4-YL]OXY]-9H-CARBOZOL-9-YL] METHYL]NAPHTHALENE-2-CARBOXIMIDAMIDE (ZK-806450) COMPLEX
1V2U 2004-06-01 1.8 Benzamidine in complex with bovine trypsin varinat X(SSAI)bT.D1
3UNS 2012-11-21 1.8 Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor
3AAU 2010-04-07 1.8 Bovine beta-trypsin bound to meta-diguanidino schiff base copper (II) chelate
3BTF 2000-03-13 1.8 THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI.
1QB1 2000-04-29 1.8 Bovine Trypsin with 1-[2-[5-[amino(imino)methyl]-2-hydroxyphenoxy]-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]piperidine-3-carboxylic Acid (ZK-806974)
2ZDL 2008-10-14 1.8 Exploring trypsin S3 pocket
1F0T 2000-09-20 1.8 BOVINE TRYPSIN COMPLEXED WITH RPR131247
1G3D 2001-01-17 1.8 BOVINE BETA-TRYPSIN BOUND TO META-AMIDINO SCHIFF BASE COPPER (II) CHELATE
1TNK 1994-11-30 1.8 PREDICTION OF NOVEL SERINE PROTEASE INHIBITORS
2TGA 1982-03-04 1.8 ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY
1TNJ 1994-11-30 1.8 PREDICTION OF NOVEL SERINE PROTEASE INHIBITORS
1G3B 2001-01-17 1.8 BOVINE BETA-TRYPSIN BOUND TO META-AMIDINO SCHIFF BASE MAGNESIUM(II) CHELATE
1Y3U 2005-12-06 1.8 TRYPSIN INHIBITOR COMPLEX
3UQO 2012-11-21 1.8 Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor
1MAX 1996-10-14 1.8 BETA-TRYPSIN PHOSPHONATE INHIBITED
1QCP 1999-05-21 1.8 CRYSTAL STRUCTURE OF THE RWJ-51084 BOVINE PANCREATIC BETA-TRYPSIN AT 1.8 A
4GUX 2013-09-04 1.8 Crystal structure of trypsin:MCoTi-II complex
3A7Y 2010-09-29 1.81 Crystal Structure of Trypsin complexed with (E)-4-((1-methylpiperidin-3-yloxyimino)methyl)benzimidamide (soaking 2hours)
2G55 2007-02-20 1.82 Anomalous substructure of trypsin (P3121)
3BTK 2000-03-13 1.85 THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
3A8C 2010-09-29 1.85 Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid (soaking with mixture of [(E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid] and [(E)-2-(4-carbamimidoylbenzylideneaminooxy)-2-methylpropanoic acid])
3BTE 2000-03-15 1.85 The Crystal Structures of the Complexes Between Bovine Beta-Trypsin and Ten P1 Variants of BPTI.
1EJM 2001-03-03 1.85 CRYSTAL STRUCTURE OF THE BPTI ALA16LEU MUTANT IN COMPLEX WITH BOVINE TRYPSIN
4B2A 2012-08-01 1.89 Structure of the factor Xa-like trypsin variant triple-Ala (TGA) in complex with eglin C
3TPI 1983-01-18 1.9 THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS
3BTQ 2000-03-15 1.9 THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
3BTG 2000-03-13 1.9 THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
1MTV 1997-11-12 1.9 FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
1K1P 2001-11-28 1.9 BOVINE TRYPSIN-INHIBITOR COMPLEX
1CE5 1999-03-23 1.9 BOVINE PANCREAS BETA-TRYPSIN IN COMPLEX WITH BENZAMIDINE
1V2J 2004-06-01 1.9 BENZAMIDINE IN COMPLEX WITH BOVINE TRYPSIN VARIANT X(SSRI)bT.C1
3BTT 2000-03-13 1.9 THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
1MTW 1997-11-12 1.9 FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
2TGP 1983-01-18 1.9 THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS
3BTD 2000-03-13 1.9 The Crystal Structures of the Complexes Between the Bovine Beta-Trypsin and Ten P1 Variants of BPTI.
1MTU 1997-11-12 1.9 FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
1TPA 1983-01-18 1.9 THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS
2BZA 1999-03-23 1.9 BOVINE PANCREAS BETA-TRYPSIN IN COMPLEX WITH BENZYLAMINE
1G36 2001-10-23 1.9 TRYPSIN INHIBITOR COMPLEX
3V0X 2012-12-12 1.9 Bovine trypsin variant X(tripleGlu217Phe227) in complex with small molecule inhibitor
1OYQ 2003-04-29 1.9 TRYPSIN INHIBITOR COMPLEX
1MTS 1997-08-20 1.9 FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
1NC6 2003-09-23 1.9 Potent, small molecule inhibitors of human mast cell tryptase. Anti-asthmatic action of a dipeptide-based transition state analogue containing benzothiazole ketone
1ZZZ 1999-06-15 1.9 Trypsin inhibitors with rigid tripeptidyl aldehydes
1TNI 1994-11-30 1.9 PREDICTION OF NOVEL SERINE PROTEASE INHIBITORS
2PTC 1983-01-18 1.9 THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS
1TPS 1995-01-26 1.9 ATOMIC STRUCTURE OF THE TRYPSIN-A90720A COMPLEX: A UNIFIED APPROACH TO STRUCTURE AND FUNCTION
1TNL 1994-11-30 1.9 PREDICTION OF NOVEL SERINE PROTEASE INHIBITORS
1V2T 2004-06-01 1.9 Trypsin inhibitor in complex with bovine trypsin variant X(SSFI.Glu)bT.B4
1F0U 2000-09-20 1.9 BOVINE TRYPSIN COMPLEXED WITH RPR128515
1PPH 1994-01-31 1.9 GEOMETRY OF BINDING OF THE NALPHA-TOSYLATED PIPERIDIDES OF M-AMIDINO-, P-AMIDINO-AND P-GUANIDINO PHENYLALANINE TO THROMBIN AND TRYPSIN: X-RAY CRYSTAL STRUCTURES OF THEIR TRYPSIN COMPLEXES AND MODELING OF THEIR THROMBIN COMPLEXES
1XUF 1998-12-16 1.9 TRYPSIN-BABIM-ZN+2, PH 8.2
5JYI 2016-07-06 1.91 Trypsin bound with succinic acid at 1.9A
1XUJ 1998-11-11 1.92 TRYPSIN-KETO-BABIM-ZN+2, PH 8.2
1V2P 2004-06-01 1.92 Trypsin inhibitor in complex with bovine trypsin variant X(SSYI)bT.A4
2ZDM 2008-10-14 1.93 Exploring trypsin S3 pocket
6BVH 2018-12-19 1.93 Trypsin complexed with a modified sunflower trypsin inhibitor, SFTI-TCTR(N12,N14)
2TIO 1998-09-30 1.93 LOW PACKING DENSITY FORM OF BOVINE BETA-TRYPSIN IN CYCLOHEXANE
1TIO 1998-09-23 1.93 HIGH PACKING DENSITY FORM OF BOVINE BETA-TRYPSIN IN CYCLOHEXANE
3VPK 2012-05-23 1.94 Crystal Structure of 6-Guanidinohexanoyl Trypsin
2ZHD 2009-02-10 1.94 Exploring trypsin S3 pocket
6DWF 2019-01-30 1.94 Crystal structure of complex of BBKI mutant, L55R with Bovine Trypsin
3T27 2011-12-28 1.95 Orthorhombic trypsin (bovine) in the presence of betaine
2ZDN 2008-10-14 1.98 Exploring trypsin S3 pocket
1GBT 1994-01-31 2.0 STRUCTURE OF AN ACYL-ENZYME INTERMEDIATE DURING CATALYSIS: (GUANIDINOBENZOYL) TRYPSIN
1V2K 2004-06-01 2.0 Factor XA specific Inhibitor in complex with bovine trypsin variant X(triple.Glu)bT.D2
6B6R 2017-11-01 2.0 Orthorhombic trypsin cryocooled to 100 K with 50% mpd as cryoprotectant
1OX1 2004-05-18 2.0 crystal structure of the bovine trypsin complex with a synthetic 11 peptide inhibitor
6B6T 2018-03-14 2.0 Orthorhombic trypsin cryocooled to 100 K with 50% methanol as cryoprotectant
6AVL 2017-09-20 2.0 Orthorhombic Trypsin (295 K) in the presence of 50% xylose
1TYN 1995-01-26 2.0 ATOMIC STRUCTURE OF THE TRYPSIN-CYCLOTHEONAMIDE A COMPLEX: LESSONS FOR THE DESIGN OF SERINE PROTEASE INHIBITORS
2D8W 2006-07-11 2.0 Structure of HYPER-VIL-trypsin
1BTZ 1995-10-15 2.0 Episelection: novel KI ~nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface
6B6N 2017-11-01 2.0 Orthorhombic trypsin (295 K) in the presence of 50% mpd
1O3A 2003-09-02 2.0 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
6B6P 2017-11-01 2.0 Orthorhombic trypsin cryocooled to 100 K with 30% xylose as cryoprotectant
2ILN 2007-04-10 2.0 Crystal structure of the Bowman-Birk inhibitor from snail medic seeds in complex with bovine trypsin
6B6Q 2017-11-01 2.0 Orthorhombic trypsin cryocooled to 100 K with 50% xylose as cryoprotectant
1EB2 2002-02-11 2.0 Trypsin inhibitor complex (BPO)
4AOQ 2013-01-09 2.0 Cationic trypsin in complex with mutated Spinacia oleracea trypsin inhibitor III (SOTI-III) (F14A)
3PYH 2011-12-21 2.0 Bovine trypsin variant X(tripleGlu217Ile227) in complex with small molecule inhibitor
1JIR 2001-07-18 2.0 Crystal Structure of Trypsin Complex with Amylamine in Cyclohexane
4J2Y 2013-05-08 2.0 Crystal structure of a plant trypsin inhibitor EcTI in complex with bovine trypsin.
1K1N 2001-11-28 2.0 BOVINE TRYPSIN-INHIBITOR COMPLEX
1PPE 1994-01-31 2.0 THE REFINED 2.0 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN BOVINE BETA-TRYPSIN AND CMTI-I, A TRYPSIN INHIBITOR FROM SQUASH SEEDS (CUCURBITA MAXIMA): TOPOLOGICAL SIMILARITY OF THE SQUASH SEED INHIBITORS WITH THE CARBOXYPEPTIDASE A INHIBITOR FROM POTATOES
6B6S 2017-11-01 2.0 Orthorhombic trypsin cryocooled to 100 K with 50% ethanol as cryoprotectant
1K1O 2001-11-28 2.0 BOVINE TRYPSIN-INHIBITOR COMPLEX
6DWH 2019-01-30 2.0 Crystal structure of complex of BBKI and Bovine Trypsin
3BTW 2000-03-13 2.05 THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
3QK1 2011-03-23 2.08 Crystal Structure of Enterokinase-like Trypsin Variant
2A7H 2005-07-19 2.1 On the Routine Use of Soft X-Rays in Macromolecular Crystallography, Part III- The Optimal Data Collection Wavelength
1SMF 1994-07-31 2.1 Studies on an artificial trypsin inhibitor peptide derived from the mung bean inhibitor
1QL7 2000-08-25 2.1 FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
2TPI 1982-03-04 2.1 ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY
3UUZ 2012-12-05 2.1 Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor
1YYY 1999-06-08 2.1 Trypsin inhibitors with rigid tripeptidyl aldehydes
1YP9 2006-01-17 2.1 Trypsin Inhibitor Complex
2TGD 1986-05-07 2.1 LACK OF THE TRANSITION STATE STABILIZATION SITE IS A FACTOR IN THE INACTIVITY OF TRYPSINOGEN, A SERINE PROTEASE ZYMOGEN. STRUCTURE OF DFP INHIBITED BOVINE TRYPSINOGEN AT 2.1 ANGSTROMS RESOLUTION
1AUJ 1998-10-14 2.1 BOVINE TRYPSIN COMPLEXED TO META-CYANO-BENZYLIC INHIBITOR
1G9I 2000-12-06 2.2 CRYSTAL STRUCTURE OF BETA-TRYSIN COMPLEX IN CYCLOHEXANE
1K1I 2001-11-28 2.2 BOVINE TRYPSIN-INHIBITOR COMPLEX
1BTP 1996-01-29 2.2 UNIQUE BINDING OF A NOVEL SYNTHETIC INHIBITOR, N-[3-[4-[4-(AMIDINOPHENOXY)-CARBONYL]PHENYL]-2-METHYL-2-PROPENOYL]-N-ALLYLGLYCINE METHANESULFONATE TO BOVINE TRYPSIN, REVEALED BY THE CRYSTAL STRUCTURE OF THE COMPLEX
6DZF 2018-09-19 2.2 Orthorhombic trypsin cryocooled to 100 K with 20% xylose as cryoprotectant
1K1J 2001-11-28 2.2 BOVINE TRYPSIN-INHIBITOR COMPLEX
1K1M 2001-11-28 2.2 BOVINE TRYPSIN-INHIBITOR COMPLEX
4TPI 1985-11-08 2.2 THE REFINED 2.2-ANGSTROMS (0.22-NM) X-RAY CRYSTAL STRUCTURE OF THE TERNARY COMPLEX FORMED BY BOVINE TRYPSINOGEN, VALINE-VALINE AND THE ARG15 ANALOGUE OF BOVINE PANCREATIC TRYPSIN INHIBITOR
3M35 2010-04-21 2.2 Trypsin in complex with the inhibitor 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423)
6FID 2018-02-07 2.2 Bovine trypsin solved by S-SAD on ID30B
1AQ7 1998-02-25 2.2 TRYPSIN WITH INHIBITOR AERUGINOSIN 98-B
1XUH 1998-11-11 2.2 TRYPSIN-KETO-BABIM-CO+2, PH 8.2
1LQE 2003-05-10 2.2 CRYSTAL STRUCTURE OF TRYPSIN IN COMPLEX WITH 79.
2CMY 2007-05-22 2.25 Crystal complex between bovine trypsin and Veronica hederifolia trypsin inhibitor
3VEQ 2012-10-03 2.25 A binary complex betwwen bovine pancreatic trypsin and a engineered mutant trypsin inhibitor
3RDZ 2011-07-06 2.26 Crystal Structure of rBTI-trypsin complex at 2.26 angstrom resolution
1OPH 2003-08-05 2.3 NON-COVALENT COMPLEX BETWEEN ALPHA-1-PI-PITTSBURGH AND S195A TRYPSIN
1TAB 1992-01-15 2.3 STRUCTURE OF THE TRYPSIN-BINDING DOMAIN OF BOWMAN-BIRK TYPE PROTEASE INHIBITOR AND ITS INTERACTION WITH TRYPSIN
1V2Q 2004-06-01 2.3 Trypsin inhibitor in complex with bovine trypsin variant X(SSWI)bT.B4
1D6R 2000-05-05 2.3 CRYSTAL STRUCTURE OF CANCER CHEMOPREVENTIVE BOWMAN-BIRK INHIBITOR IN TERNARY COMPLEX WITH BOVINE TRYPSIN AT 2.3 A RESOLUTION. STRUCTURAL BASIS OF JANUS-FACED SERINE PROTEASE INHIBITOR SPECIFICITY
3I29 2010-06-16 2.4 Crystal structure of a binary complex between an mutant trypsin inhibitor with bovine trypsin
6B6O 2018-02-21 2.4 Orthorhombic trypsin cryocooled to 100 K with 20% xylose as cryoprotectant
3UQV 2012-11-21 2.4 Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor
3E8L 2009-07-28 2.48 The Crystal Structure of the Double-headed Arrowhead Protease Inhibitor A in Complex with Two Trypsins
1K1L 2001-11-28 2.5 BOVINE TRYPSIN-INHIBITOR COMPLEX
2F3C 2006-12-05 2.5 Crystal structure of infestin 1, a Kazal-type serineprotease inhibitor, in complex with trypsin
1EZX 2000-10-25 2.6 CRYSTAL STRUCTURE OF A SERPIN:PROTEASE COMPLEX
2QYI 2008-08-19 2.6 Crystal structure of a binary complex between an engineered trypsin inhibitor and Bovine trypsin
2TLD 1992-07-15 2.6 CRYSTAL STRUCTURE OF AN ENGINEERED SUBTILISIN INHIBITOR COMPLEXED WITH BOVINE TRYPSIN
5GIB 2016-08-10 2.7 Succinic acid bound trypsin crystallized as dimer
5GXP 2016-11-02 2.8 Cationic Trypsin With GOL/PGE as Dimer at pH 4.6
3T28 2011-12-28 2.8 TMAO-grown trypsin (bovine)-previously unreported tetragonal crystal form
4NIY 2014-02-19 2.84 Crystal structure of trypsiligase (K60E/N143H/Y151H/D189K trypsin) complexed to YRH-ecotin (M84Y/M85R/A86H ecotin)
2QN5 2008-07-22 3.0 Crystal Structure and Functional Study of the Bowman-Birk Inhibitor from Rice Bran in Complex with Bovine Trypsin
1QL8 2000-08-25 3.0 FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
3UY9 2012-12-12 3.22 Bovine trypsin variant X(tripleGlu217Phe227) in complex with small molecule inhibitor
1C9T 2000-08-03 3.3 COMPLEX OF BDELLASTASIN WITH BOVINE TRYPSIN
6DWU 2019-01-30 3.96 Crystal structure of complex of BBKI and Bovine Trypsin

Relevant UniProtKB Entries

Percent Identity Matching Chains Protein Accession Entry Name
100.0 Cationic trypsin P00760 TRY1_BOVIN