Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability.


Abstract

Bacteriophage T4 lysozyme is a basic molecule with an isoelectric point above 9.0, and an excess of nine positive charges at neutral pH. It might be expected that it would be energetically costly to bring these out-of-balance charges from the extended, unfolded, form of the protein into the compact folded state. To determine the contribution of such long-range electrostatic interactions to the stability of the protein, five positively charged surface residues, Lys16, Arg119, Lys135, Lys147 and Arg154, were individually replaced with glutamic acid. Eight selected double, triple and quadruple mutants were also constructed so as to sequentially reduce the out-of-balance formal charge on the molecule from +9 to +1 units. Each of the five single variant proteins was crystallized and high-resolution X-ray analysis confirmed that each mutant structure was, in general, very similar to the wild-type. In the case of R154E, however, the Arg154 to Glu replacement caused a rearrangement in which Asp127 replaced Glu128 as the capping residue of a nearby alpha-helix. The thermal stabilities of all 13 variant proteins were found to be fairly similar, ranging from 0.5 kcal/mol more stable than wild-type to 1.7 kcal/mol less stable than wild-type. In the case of the five single charge-change variants, for which the structures were determined, the changes in stability can be rationalized in terms of changes in local interactions at the site of the replacement. There is no evidence that the reduction in the out-of-balance charge on the molecule increases the stability of the folded relative to the unfolded form, either at pH 2.8 or at pH 5.3. This indicates that long-range electrostatic interactions between the substituted amino acid residues and other charged groups on the surface of the molecule are weak or non-existent. Furthermore, the relative stabilities of the multiple charge replacement mutant proteins were found to be almost exactly equal to the sums of the relative stabilities of the constituent single mutant proteins. This also clearly indicates that the electrostatic interactions between the replaced charges are negligibly small. The activities of the charge-change mutant lysozymes, as measured by the rate of hydrolysis of cell wall suspensions, are essentially equal to that of the wild-type lysozyme, but on a lysoplate assay the mutant enzymes appear to have higher activity.(ABSTRACT TRUNCATED AT 400 WORDS) Study holds ProTherm entries: 1028, 1029, 1030, 1031, 1032, 1033, 1034, 1035, 1036, 1037, 1038, 1039, 1040, 1041, 1042, 1043, 1044, 1045, 1046, 1047, 1048, 1049, 1050, 1051, 1052, 1053, 1054, 1055, 13463, 13464, 13465, 13466, 13467, 13468, 13469, 13470, 13471, 13472, 13473, 13474, 13475, 13476, 13477, 13478, 13479, 13480, 13481, 13482, 13483, 13484, 13485, 13486, 13487, 13488 Extra Details: protein structure; electrostatics; lysozyme;,mutagenesis; crystallography

Submission Details

ID: o9ngPtNL4

Submitter: Connie Wang

Submission Date: April 24, 2018, 8:16 p.m.

Version: 1

Publication Details
Dao-pin S;Söderlind E;Baase WA;Wozniak JA;Sauer U;Matthews BW,J. Mol. Biol. (1991) Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability. PMID:1942034
Additional Information

Structure view and single mutant data analysis

Study data

No weblogo for data of varying length.
Colors: D E R H K S T N Q A V I L M F Y W C G P
 

Data Distribution

Studies with similar sequences (approximate matches)

Correlation with other assays (exact sequence matches)


Relevant PDB Entries

Structure ID Release Date Resolution Structure Title
2LCB 2011-08-17 Solution Structure of a Minor and Transiently Formed State of a T4 Lysozyme Mutant
2LC9 2011-08-17 Solution Structure of a Minor and Transiently Formed State of a T4 Lysozyme Mutant
5XPE 2017-10-04 Neutron structure of the T26H mutant of T4 lysozyme
2O7A 2007-04-10 0.84 T4 lysozyme C-terminal fragment
5JDT 2016-09-28 1.0 Structure of Spin-labelled T4 lysozyme mutant L118C-R1 at 100K
5XPF 2017-10-04 1.04 High-resolution X-ray structure of the T26H mutant of T4 lysozyme
6BG3 2018-09-26 1.05 Structure of (3S,4S)-1-benzyl-4-(3-(3-(trifluoromethyl)phenyl)ureido)piperidin-3-yl acetate bound to DCN1
1SWY 2004-11-23 1.06 Use of a Halide Binding Site to Bypass the 1000-atom Limit to Ab initio Structure Determination
1SX7 2004-11-30 1.06 Use of an ion-binding site to bypass the 1000-atom limit to ab initio structure determination by direct methods
1SX2 2004-11-23 1.06 Use of a Halide Binding Site to Bypass the 1000-atom Limit to Structure Determination by Direct Methods
1SWZ 2005-01-18 1.06 Use of an ion-binding site to bypass the 1000-atom limit to ab initio structure determination by direct methods
3F8V 2009-02-17 1.08 Evaulaution at Atomic Resolution of the Role of Strain in Destabilizing the Temperature Sensitive T4 Lysozyme Mutant Arg96-->His
3FA0 2009-02-17 1.09 Evaulaution at Atomic Resolution of the Role of Strain in Destabilizing the Temperature Sensitive T4 Lysozyme Mutant Arg96-->His
6BG5 2018-09-26 1.1 Structure of 1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-(1-propylpiperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)urea bound to DCN1
5LWO 2017-03-08 1.18 Structure of Spin-labelled T4 lysozyme mutant L115C-R119C-R1 at 100K
3F9L 2009-02-17 1.19 Evaulaution at Atomic Resolution of the Role of Strain in Destabilizing the Temperature Sensitive T4 Lysozyme Mutant Arg96-->His
3FAD 2009-02-17 1.2 Evaulaution at Atomic Resolution of the Role of Strain in Destabilizing the Temperature Sensitive T4 Lysozyme Mutant Arg96-->His
3HH6 2009-10-13 1.25 New azaborine compounds bind to the T4 lysozyme L99A cavity -ethylbenzene as control
3HH4 2009-10-13 1.25 New azaborine compounds bind to the T4 lysozyme L99A cavity - Benzene as control
3HH3 2009-10-13 1.25 New azaborine compounds bind to the T4 lysozyme L99A cavity - 1,2-dihydro-1,2-azaborine
3DKE 2008-11-25 1.25 Polar and non-polar cavities in phage T4 lysozyme
3HH5 2009-10-13 1.25 New azaborine compounds bind to the T4 lysozyme L99A cavity - 1-ethyl-2-hydro-1,2-azaborine
3HTG 2009-11-03 1.26 2-ethoxy-3,4-dihydro-2h-pyran in complex with T4 lysozyme L99A/M102Q
2RBO 2008-03-18 1.29 2-nitrothiophene in complex with T4 lysozyme L99A/M102Q
2RBN 2008-03-18 1.29 N-phenylglycinonitrile in complex with T4 lysozyme L99A/M102Q
3HUK 2009-11-03 1.29 Benzylacetate in complex with T4 lysozyme L99A/M102Q
4E97 2012-09-05 1.3 T4 Lysozyme L99A/M102H with 2-Mercaptoethanol Bound
5JWV 2016-09-21 1.3 T4 Lysozyme L99A/M102Q with Ethylbenzene Bound
6D9M 2019-04-10 1.35 T4-Lysozyme fusion to Geobacter GGDEF
5V7D 2018-06-20 1.35 T4 lysozyme Y18Ymbr
5V7E 2018-06-20 1.36 T4 lysozyme Y18Ymcl
5V86 2017-05-24 1.37 Structure of DCN1 bound to NAcM-OPT
4W59 2015-04-01 1.39 T4 Lysozyme L99A with n-Hexylbenzene Bound
2IGC 2007-06-12 1.4 Structure of Spin labeled T4 Lysozyme Mutant T115R1A
3RUN 2012-06-06 1.4 New strategy to analyze structures of glycopeptide antibiotic-target complexes
2NTG 2007-06-12 1.4 Structure of Spin-labeled T4 Lysozyme Mutant T115R7
2Q9D 2007-06-26 1.4 Structure of spin-labeled T4 lysozyme mutant A41R1
3HTD 2009-11-03 1.4 (Z)-Thiophene-2-carboxaldoxime in complex with T4 lysozyme L99A/M102Q
3HUA 2009-11-03 1.4 4,5,6,7-tetrahydroindole in complex with T4 lysozyme L99A/M102Q
5JWT 2016-09-21 1.41 T4 Lysozyme L99A/M102Q with Benzene Bound
3SBB 2011-09-21 1.43 Disulphide-mediated Tetramer of T4 Lysozyme R76C/R80C by Synthetic Symmetrization
2RBR 2008-03-18 1.43 2-phenoxyethanol in complex with T4 lysozyme L99A/M102Q
4W51 2015-04-01 1.45 T4 Lysozyme L99A with No Ligand Bound
1P36 2003-10-07 1.45 T4 LYOSZYME CORE REPACKING MUTANT I100V/TA
2F2Q 2006-04-25 1.45 High resolution crystal strcuture of T4 lysozyme mutant L20R63/A liganded to guanidinium ion
3HUQ 2009-11-03 1.45 Thieno[3,2-b]thiophene in complex with T4 lysozyme L99A/M102Q
1LW9 2003-05-20 1.45 Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability
3GUI 2009-08-25 1.45 T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--Apo structure
5KI1 2017-04-12 1.46 PSEUDO T4 LYSOZYME MUTANT - Y18F
5JGR 2017-02-15 1.46 Spin-Labeled T4 Lysozyme Construct K43V1
3HU9 2009-11-03 1.46 Nitrosobenzene in complex with T4 lysozyme L99A/M102Q
2RB2 2008-03-18 1.46 3-methylbenzylazide in complex with T4 lysozyme L99A
5JGU 2017-02-15 1.47 Spin-Labeled T4 Lysozyme Construct R119V1
5JWW 2016-09-21 1.47 T4 Lysozyme L99A/M102Q with 1-Hydro-2-ethyl-1,2-azaborine Bound
5KGR 2017-02-15 1.47 Spin-Labeled T4 Lysozyme Construct I9V1/V131V1 (30 days)
2RBP 2008-03-18 1.47 2-(n-propylthio)ethanol in complex with T4 lysozyme L99A/M102Q
4I7M 2013-03-27 1.48 T4 Lysozyme L99A/M102H with 2-allylphenol bound
4EKR 2012-09-05 1.49 T4 Lysozyme L99A/M102H with 2-Cyanophenol Bound
5KHZ 2017-04-12 1.49 PSEUDO T4 LYSOZYME
3GUN 2009-08-25 1.5 T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--aniline binding
5KIM 2017-04-12 1.5 PSEUDO T4 LYSOZYME MUTANT - Y88PHE-I
5KIG 2017-04-12 1.5 PSEUDO T4 LYSOZYME MUTANT - Y88F
3GUP 2009-08-25 1.5 T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--pyridine binding
5KI2 2017-04-12 1.5 PSEUDO T4 LYSOZYME MUTANT - Y18PHE-METHYL
3K2R 2010-10-13 1.5 Crystal Structure of Spin Labeled T4 Lysozyme Mutant K65V1/R76V1
4W52 2015-04-01 1.5 T4 Lysozyme L99A with Benzene Bound
1P7S 2003-10-07 1.5 T4 LYSOZYME CORE REPACKING MUTANT V103I/TA
1PQM 2003-10-07 1.52 T4 Lysozyme Core Repacking Mutant V149I/T152V/TA
4I7L 2013-04-03 1.52 T4 Lysozyme L99A/M102H with phenol bound
4I7R 2013-03-27 1.52 T4 Lysozyme L99A/M102H with 2-(pyrazolo-1-yl) ethanol bound
5JGX 2017-02-15 1.53 Spin-Labeled T4 Lysozyme Construct V131V1
5JGN 2017-02-15 1.53 Spin-Labeled T4 Lysozyme Construct I9V1
3FI5 2009-02-17 1.53 Crystal Structure of T4 Lysozyme Mutant R96W
5JGZ 2017-02-15 1.53 Spin-Labeled T4 Lysozyme Construct T151V1
4EKQ 2012-09-05 1.54 T4 Lysozyme L99A/M102H with 4-Nitrophenol Bound
1P6Y 2003-10-07 1.54 T4 LYSOZYME CORE REPACKING MUTANT M120Y/TA
1P3N 2003-10-07 1.55 CORE REDESIGN BACK-REVERTANT I103V/CORE10
1XEP 2005-05-31 1.55 Catechol in complex with T4 lysozyme L99A/M102Q
4I7T 2013-03-27 1.55 T4 Lysozyme L99A/M102H with 2-bromo-5-hydroxybenzaldehyde bound
5KI8 2017-04-12 1.55 PSEUDO T4 LYSOZYME MUTANT - Y88PHE-BR
2OU9 2007-06-12 1.55 Structure of Spin-labeled T4 Lysozyme Mutant T115R1/R119A
2RBS 2008-03-18 1.56 (r)(+)-3-chloro-1-phenyl-1-propanol in complex with T4 lysozyme L99A/M102Q
4W53 2015-04-01 1.56 T4 Lysozyme L99A with Toluene Bound
5KII 2017-04-12 1.56 PSEUDO T4 LYSOZYME MUTANT - Y88PHE-METHYL
1P37 2003-10-07 1.57 T4 LYSOZYME CORE REPACKING BACK-REVERTANT L102M/CORE10
1PQI 2003-10-07 1.57 T4 LYSOZYME CORE REPACKING MUTANT I118L/CORE7/TA
1P2L 2003-10-07 1.58 T4 Lysozyme Core Repacking Mutant V87I/TA
4I7N 2013-03-27 1.58 T4 Lysozyme L99A/M102H with 1-phenyl-2-propyn-1-ol bound
1P2R 2003-10-07 1.58 T4 LYSOZYME CORE REPACKING MUTANT I78V/TA
4I7Q 2013-03-27 1.58 T4 Lysozyme L99A/M102H with 4-trifluoromethylimidazole bound
3HT6 2009-11-03 1.59 2-methylphenol in complex with T4 lysozyme L99A/M102Q
3HT8 2009-11-03 1.6 5-chloro-2-methylphenol in complex with T4 lysozyme L99A/M102Q
3GUJ 2009-08-25 1.6 T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--Benzene binding
5V88 2017-05-24 1.6 Structure of DCN1 bound to NAcM-COV
4I7P 2013-03-27 1.6 T4 Lysozyme L99A/M102H with 4-bromoimidazole bound
1ZUR 2006-10-17 1.6 Crystal structure of spin labeled T4 Lysozyme (V131R1F)
5G27 2016-11-23 1.61 Structure of Spin-labelled T4 lysozyme mutant L118C-R1 at Room Temperature
1P64 2003-10-07 1.62 T4 LYSOZYME CORE REPACKING MUTANT L133F/TA
5VNR 2017-07-26 1.63 X-ray strucutre of perdeuterated T4 lysozyme cysteine-free pseudo-wild type at cryogenic temperature
3CDT 2009-02-17 1.63 Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme
4W56 2015-04-01 1.63 T4 Lysozyme L99A with sec-Butylbenzene Bound
5KIO 2017-04-12 1.63 PSEUDO T4 LYSOZYME MUTANT - Y18PHE-I
2RBQ 2008-03-18 1.63 3-methylbenzylazide in complex with T4 L99A/M102Q
4EKS 2012-09-05 1.64 T4 Lysozyme L99A/M102H with Isoxazole Bound
4W55 2015-04-01 1.64 T4 Lysozyme L99A with n-Propylbenzene Bound
2RAZ 2008-03-18 1.64 4-(methylthio)nitrobenzene in complex with T4 lysozyme L99A
3C8Q 2009-02-17 1.64 Contribution of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme
4EKP 2012-09-05 1.64 T4 Lysozyme L99A/M102H with Nitrobenzene Bound
1L58 1991-10-15 1.65 ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
3DMV 2008-11-11 1.65 Free of ligand binding in the hydrophobic cavity of T4 lysozyme L99A mutant
5JWS 2016-09-21 1.65 T4 Lysozyme L99A with 1-Hydro-2-ethyl-1,2-azaborine Bound
1PQD 2003-10-07 1.65 T4 LYSOZYME CORE REPACKING MUTANT CORE10/TA
119L 1993-10-31 1.65 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
5KI3 2017-04-12 1.65 PSEUDO T4 LYSOZYME MUTANT - Y18PHE-BR
5V7F 2018-06-20 1.65 T4 lysozyme Y18Ymi
1PQO 2003-10-07 1.65 T4 Lysozyme Core Repacking Mutant L118I/TA
1LPY 2002-05-22 1.65 Multiple Methionine Substitutions in T4 Lysozyme
219L 1996-12-23 1.66 PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
1P46 2003-10-07 1.67 T4 lysozyme core repacking mutant M106I/TA
4I7J 2013-03-27 1.67 T4 Lysozyme L99A/M102H with benzene bound
3C7Z 2009-02-17 1.67 T4 lysozyme mutant D89A/R96H at room temperature
3CDQ 2009-02-17 1.68 Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme
3C82 2009-02-17 1.68 Bacteriophage lysozyme T4 lysozyme mutant K85A/R96H
3C8S 2009-02-17 1.68 Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme
4W57 2015-04-01 1.68 T4 Lysozyme L99A with n-Butylbenzene Bound
4I7S 2013-03-27 1.69 T4 Lysozyme L99A/M102H with 3-trifluoromethyl-5-methyl pyrazole bound
221L 1994-01-31 1.7 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
161L 1994-08-31 1.7 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
1L65 1991-10-15 1.7 TOLERANCE OF T4 LYSOZYME TO MULTIPLE XAA (RIGHT ARROW) ALA SUBSTITUTIONS: A POLYALANINE ALPHA-HELIX CONTAINING TEN CONSECUTIVE ALANINES
1L92 1993-10-31 1.7 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
1G07 2001-05-23 1.7 CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT V149C
211L 1996-12-23 1.7 PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
1L33 1990-01-15 1.7 CONTRIBUTIONS OF LEFT-HANDED HELICAL RESIDUES TO THE STRUCTURE AND STABILITY OF BACTERIOPHAGE T4 LYSOZYME
1L62 1991-10-15 1.7 ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
2A4T 2006-06-13 1.7 Crystal structure of spin labeled T4 Lysozyme (V131R7)
3DNA 2008-11-11 1.7 Iodobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant (seleno version)
1L68 1991-10-15 1.7 TOLERANCE OF T4 LYSOZYME TO MULTIPLE XAA (RIGHT ARROW) ALA SUBSTITUTIONS: A POLYALANINE ALPHA-HELIX CONTAINING TEN CONSECUTIVE ALANINES
1ZYT 2006-08-15 1.7 Crystal structure of spin labeled T4 Lysozyme (A82R1)
138L 1994-01-31 1.7 RAPID CRYSTALLIZATION OF T4 LYSOZYME BY INTERMOLECULAR DISULFIDE CROSSLINKING
1L08 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
1L22 1990-01-15 1.7 CONTRIBUTIONS OF LEFT-HANDED HELICAL RESIDUES TO THE STRUCTURE AND STABILITY OF BACTERIOPHAGE T4 LYSOZYME
4LZM 1992-07-15 1.7 COMPARISON OF THE CRYSTAL STRUCTURE OF BACTERIOPHAGE T4 LYSOZYME AT LOW, MEDIUM, AND HIGH IONIC STRENGTHS
5JWU 2016-09-21 1.7 T4 Lysozyme L99A/M102Q with 1,2-Dihydro-1,2-azaborine Bound
2F47 2006-04-25 1.7 Xray crystal structure of T4 lysozyme mutant L20/R63A liganded to methylguanidinium
1L04 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
1L74 1991-10-15 1.7 MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
1L36 1991-10-15 1.7 TOWARD A SIMPLIFICATION OF THE PROTEIN FOLDING PROBLEM: A STABILIZING POLYALANINE ALPHA-HELIX ENGINEERED IN T4 LYSOZYME
1L02 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
1L47 1991-10-15 1.7 CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY
1L29 1990-01-15 1.7 REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY
1L66 1991-10-15 1.7 TOLERANCE OF T4 LYSOZYME TO MULTIPLE XAA (RIGHT ARROW) ALA SUBSTITUTIONS: A POLYALANINE ALPHA-HELIX CONTAINING TEN CONSECUTIVE ALANINES
1LYH 1993-10-31 1.7 DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO ACID SUBSTITUTIONS AT THR 59
1LWG 2003-05-20 1.7 Multiple Methionine Substitutions are Tolerated in T4 Lysozyme and have Coupled Effects on Folding and Stability
110L 1993-10-31 1.7 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
1L30 1990-01-15 1.7 REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY
1L17 1990-01-15 1.7 HYDROPHOBIC STABILIZATION IN T4 LYSOZYME DETERMINED DIRECTLY BY MULTIPLE SUBSTITUTIONS OF ILE 3
1L32 1990-01-15 1.7 REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY
241L 1998-03-18 1.7 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
1L23 1990-01-15 1.7 ENHANCED PROTEIN THERMOSTABILITY FROM SITE-DIRECTED MUTATIONS THAT DECREASE THE ENTROPY OF UNFOLDING
1L83 1993-10-31 1.7 A CAVITY-CONTAINING MUTANT OF T4 LYSOZYME IS STABILIZED BY BURIED BENZENE
1L11 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
1L06 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
139L 1994-01-31 1.7 RAPID CRYSTALLIZATION OF T4 LYSOZYME BY INTERMOLECULAR DISULFIDE CROSSLINKING
1L07 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
1L52 1991-10-15 1.7 STRUCTURAL AND THERMODYNAMIC ANALYSIS OF THE PACKING OF TWO ALPHA-HELICES IN BACTERIOPHAGE T4 LYSOZYME
1G0M 2001-05-23 1.7 CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT T152I
237L 1998-03-18 1.7 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
1L03 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
131L 1994-01-31 1.7 STRUCTURES OF RANDOMLY GENERATED MUTANTS OF T4 LYSOZYME SHOW THAT PROTEIN STABILITY CAN BE ENHANCED BY RELAXATION OF STRAIN AND BY IMPROVED HYDROGEN BONDING VIA BOUND SOLVENT
1L45 1991-10-15 1.7 CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY
3HT7 2009-11-03 1.7 2-ethylphenol in complex with T4 lysozyme L99A/M102Q
1L24 1990-01-15 1.7 ENHANCED PROTEIN THERMOSTABILITY FROM SITE-DIRECTED MUTATIONS THAT DECREASE THE ENTROPY OF UNFOLDING
128L 1993-10-31 1.7 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
1L46 1991-10-15 1.7 CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY
1L13 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
3DN8 2008-11-11 1.7 Iodopentafluorobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant (seleno version)
217L 1993-10-31 1.7 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
2RB1 2008-06-03 1.7 2-ethoxyphenol in complex with T4 lysozyme L99A
1L19 1990-01-15 1.7 ENHANCED PROTEIN THERMOSTABILITY FROM DESIGNED MUTATIONS THAT INTERACT WITH ALPHA-HELIX DIPOLES
244L 1998-03-18 1.7 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
2LZM 1986-10-24 1.7 STRUCTURE OF BACTERIOPHAGE T4 LYSOZYME REFINED AT 1.7 ANGSTROMS RESOLUTION
1L12 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
3LZM 1990-01-15 1.7 STRUCTURAL STUDIES OF MUTANTS OF T4 LYSOZYME THAT ALTER HYDROPHOBIC STABILIZATION
173L 1995-07-10 1.7 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
1L09 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
1KNI 2001-12-28 1.7 Stabilizing Disulfide Bridge Mutant of T4 Lysozyme
3CDR 2009-02-17 1.7 R96Q Mutant of wildtype phage T4 lysozyme at 298 K
1L05 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
1L26 1990-01-15 1.7 REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY
1L44 1991-10-15 1.7 CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY
1L18 1990-01-15 1.7 HYDROPHOBIC STABILIZATION IN T4 LYSOZYME DETERMINED DIRECTLY BY MULTIPLE SUBSTITUTIONS OF ILE 3
1L60 1991-10-15 1.7 ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
1L01 1988-04-16 1.7 STRUCTURAL STUDIES OF MUTANTS OF THE LYSOZYME OF BACTERIOPHAGE T4. THE TEMPERATURE-SENSITIVE MUTANT PROTEIN THR157 (RIGHT ARROW) ILE
1L14 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
1L16 1988-04-16 1.7 STRUCTURAL ANALYSIS OF THE TEMPERATURE-SENSITIVE MUTANT OF BACTERIOPHAGE T4 LYSOZYME, GLYCINE 156 (RIGHT ARROW) ASPARTIC ACID
129L 1994-01-31 1.7 STRUCTURES OF RANDOMLY GENERATED MUTANTS OF T4 LYSOZYME SHOW THAT PROTEIN STABILITY CAN BE ENHANCED BY RELAXATION OF STRAIN AND BY IMPROVED HYDROGEN BONDING VIA BOUND SOLVENT
1L10 1988-04-16 1.7 STRUCTURAL STUDIES OF MUTANTS OF THE LYSOZYME OF BACTERIOPHAGE T4. THE TEMPERATURE-SENSITIVE MUTANT PROTEIN THR157 (RIGHT ARROW) ILE
1L15 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
1L48 1991-10-15 1.7 STRUCTURAL AND THERMODYNAMIC ANALYSIS OF THE PACKING OF TWO ALPHA-HELICES IN BACTERIOPHAGE T4 LYSOZYME
130L 1994-01-31 1.7 STRUCTURES OF RANDOMLY GENERATED MUTANTS OF T4 LYSOZYME SHOW THAT PROTEIN STABILITY CAN BE ENHANCED BY RELAXATION OF STRAIN AND BY IMPROVED HYDROGEN BONDING VIA BOUND SOLVENT
4I7K 2013-03-27 1.72 T4 Lysozyme L99A/M102H with toluene bound
5JGV 2017-02-15 1.73 Spin-Labeled T4 Lysozyme Construct A73V1
232L 1998-01-14 1.73 T4 LYSOZYME MUTANT M120K
4I7O 2013-03-27 1.73 T4 Lysozyme L99A/M102H with 2-amino-5-chlorothiazole bound
3CDV 2009-02-17 1.73 Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme
4EPI 2012-06-20 1.74 The crystal structure of pesticin-T4 lysozyme hybrid stabilized by engineered disulfide bonds
102L 1993-10-31 1.74 HOW AMINO-ACID INSERTIONS ARE ALLOWED IN AN ALPHA-HELIX OF T4 LYSOZYME
1L63 1991-10-15 1.75 ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
1L90 1993-10-31 1.75 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
180L 1996-04-03 1.75 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
240L 1998-03-18 1.75 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
1L41 1991-10-15 1.75 CONTRIBUTIONS OF ENGINEERED SURFACE SALT BRIDGES TO THE STABILITY OF T4 LYSOZYME DETERMINED BY DIRECTED MUTAGENESIS
1DYB 1993-10-31 1.75 DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME
165L 1994-08-31 1.75 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
1QUD 1999-07-08 1.75 L99G MUTANT OF T4 LYSOZYME
1L59 1991-10-15 1.75 ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
243L 1998-03-18 1.75 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
5I14 2016-02-17 1.75 Truncated and mutated T4 lysozyme
2CUU 2006-08-15 1.75 Crystal structure of spin labeled T4 Lysozyme (V131R1)
247L 1998-03-18 1.75 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
166L 1994-08-31 1.75 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
1KW5 2003-06-03 1.75 METHIONINE CORE MUTANT OF T4 LYSOZYME
206L 1996-08-17 1.75 PHAGE T4 LYSOZYME
212L 1996-12-23 1.76 PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
3C7W 2009-02-17 1.77 Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme
6FW2 2018-10-31 1.78 Crystal Structure of human mARC1
4W54 2015-04-01 1.79 T4 Lysozyme L99A with Ethylbenzene Bound
1QT5 1999-07-08 1.8 D20E MUTANT STRUCTURE OF T4 LYSOZYME
2F32 2006-04-25 1.8 Xray crystal structure of lysozyme mutant L20/R63A liganded to ethylguanidinium
160L 1994-08-31 1.8 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
1QT7 1999-07-08 1.8 E11N Mutant of T4 Lysozyme
113L 1993-10-31 1.8 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
4W58 2015-04-01 1.8 T4 Lysozyme L99A with n-Pentylbenzene Bound
5LZM 1992-07-15 1.8 COMPARISON OF THE CRYSTAL STRUCTURE OF BACTERIOPHAGE T4 LYSOZYME AT LOW, MEDIUM, AND HIGH IONIC STRENGTHS
184L 1995-07-10 1.8 SPECIFICITY OF LIGAND BINDING IN A BURIED NON-POLAR CAVITY OF T4 LYSOZYME: LINKAGE OF DYNAMICS AND STRUCTURAL PLASTICITY
114L 1993-10-31 1.8 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
3DN4 2008-11-11 1.8 Iodobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant
1L91 1993-10-31 1.8 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
162L 1994-08-31 1.8 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
2RAY 2008-03-18 1.8 beta-chlorophenetole in complex with T4 lysozyme L99A
126L 1993-10-31 1.8 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
229L 1998-03-18 1.8 GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS
1LYF 1993-10-31 1.8 DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO ACID SUBSTITUTIONS AT THR 59
256L 1998-05-27 1.8 BACTERIOPHAGE T4 LYSOZYME
185L 1995-07-10 1.8 SPECIFICITY OF LIGAND BINDING IN A BURIED NON-POLAR CAVITY OF T4 LYSOZYME: LINKAGE OF DYNAMICS AND STRUCTURAL PLASTICITY
1LYG 1993-10-31 1.8 DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO ACID SUBSTITUTIONS AT THR 59
7LZM 1992-07-15 1.8 COMPARISON OF THE CRYSTAL STRUCTURE OF BACTERIOPHAGE T4 LYSOZYME AT LOW, MEDIUM, AND HIGH IONIC STRENGTHS
3DN1 2008-11-11 1.8 Chloropentafluorobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant
2NTH 2007-06-12 1.8 Structure of Spin-labeled T4 Lysozyme Mutant L118R1
1CV3 1999-08-24 1.8 T4 LYSOZYME MUTANT L121M
260L 2000-09-11 1.8 AN ADAPTABLE METAL-BINDING SITE ENGINEERED INTO T4 LYSOZYME
3L2X 2011-01-05 1.8 Crystal Structure of Spin Labeled T4 Lysozyme Mutant 115-119RX
250L 1998-03-18 1.8 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
188L 1995-07-10 1.8 SPECIFICITY OF LIGAND BINDING IN A BURIED NON-POLAR CAVITY OF T4 LYSOZYME: LINKAGE OF DYNAMICS AND STRUCTURAL PLASTICITY
1L94 1993-10-31 1.8 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
1ZWN 2006-10-17 1.8 Crystal structure of spin labeled T4 Lysozyme (V131R1B)
181L 1995-07-10 1.8 SPECIFICITY OF LIGAND BINDING IN A BURIED NON-POLAR CAVITY OF T4 LYSOZYME: LINKAGE OF DYNAMICS AND STRUCTURAL PLASTICITY
107L 1993-10-31 1.8 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
1L87 1993-10-31 1.8 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
183L 1995-07-10 1.8 SPECIFICITY OF LIGAND BINDING IN A BURIED NON-POLAR CAVITY OF T4 LYSOZYME: LINKAGE OF DYNAMICS AND STRUCTURAL PLASTICITY
1G1W 2001-05-09 1.8 T4 LYSOZYME MUTANT C54T/C97A/Q105M
1LYJ 1993-10-31 1.8 DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO ACID SUBSTITUTIONS AT THR 59
112L 1993-10-31 1.8 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
115L 1993-10-31 1.8 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
3DN0 2008-11-11 1.8 Pentafluorobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant
1L98 1993-10-31 1.8 PERTURBATION OF TRP 138 IN T4 LYSOZYME BY MUTATIONS AT GLN 105 USED TO CORRELATE CHANGES IN STRUCTURE, STABILITY, SOLVATION, AND SPECTROSCOPIC PROPERTIES
1C69 2000-10-04 1.8 T4 LYSOZYME MUTANT C54T/C97A/L133A IN THE PRESENCE OF 8 ATM ARGON
156L 1994-08-31 1.8 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
158L 1994-08-31 1.8 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
1L31 1990-01-15 1.8 REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY
1L80 1993-04-15 1.8 DESIGN AND STRUCTURAL ANALYSIS OF ALTERNATIVE HYDROPHOBIC CORE PACKING ARRANGEMENTS IN BACTERIOPHAGE T4 LYSOZYME
1L27 1990-01-15 1.8 REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY
255L 1998-01-28 1.8 HYDROLASE
1L42 1991-10-15 1.8 CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY
1L49 1991-10-15 1.8 STRUCTURAL AND THERMODYNAMIC ANALYSIS OF THE PACKING OF TWO ALPHA-HELICES IN BACTERIOPHAGE T4 LYSOZYME
1T8G 2004-10-19 1.8 Crystal structure of phage T4 lysozyme mutant L32A/L33A/T34A/C54T/C97A/E108V
2O79 2007-04-10 1.8 T4 lysozyme with C-terminal extension
108L 1993-10-31 1.8 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
3C8R 2009-02-17 1.8 Contributions of all 20 amino acids at site 96 to stability and structure of T4 lysozyme
1L61 1991-10-15 1.8 ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
1G0J 2001-05-23 1.8 CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT T152S
159L 1994-08-31 1.8 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
3DN3 2008-11-11 1.8 Iodopentafluorobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant
1P56 2004-05-04 1.8 Duplication-extension of Helix A of T4 lysozyme
1G0P 2001-05-23 1.8 CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT V149G
186L 1995-07-10 1.8 SPECIFICITY OF LIGAND BINDING IN A BURIED NON-POLAR CAVITY OF T4 LYSOZYME: LINKAGE OF DYNAMICS AND STRUCTURAL PLASTICITY
3DMX 2009-01-27 1.8 Benzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant
246L 1998-03-18 1.8 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
111L 1993-10-31 1.8 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
1L86 1993-10-31 1.8 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
163L 1994-08-31 1.8 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
1L38 1991-10-15 1.8 CONTRIBUTIONS OF ENGINEERED SURFACE SALT BRIDGES TO THE STABILITY OF T4 LYSOZYME DETERMINED BY DIRECTED MUTAGENESIS
1G0L 2001-05-23 1.8 CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT T152V
122L 1993-10-31 1.8 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
242L 1998-03-18 1.8 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
1L25 1990-01-15 1.8 REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY
226L 1998-03-18 1.8 GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS
3HU8 2009-11-03 1.8 2-ethoxyphenol in complex with T4 lysozyme L99A/M102Q
2OU8 2007-06-12 1.8 Structure of Spin-labeled T4 Lysozyme Mutant T115R1 at Room Temperature
1DYE 1993-10-31 1.8 DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME
239L 1998-03-18 1.8 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
182L 1995-07-10 1.8 SPECIFICITY OF LIGAND BINDING IN A BURIED NON-POLAR CAVITY OF T4 LYSOZYME: LINKAGE OF DYNAMICS AND STRUCTURAL PLASTICITY
1G0Q 2001-05-23 1.8 CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT V149I
3HWL 2009-12-08 1.8 Crystal Structure of T4 lysozyme with the unnatural amino acid p-Acetyl-L-Phenylalanine incorporated at position 131
1NHB 1995-07-10 1.8 Specificity of ligand binding in a buried non-polar cavity of t4 lysozyme: linkage of dynamics and structural plasticity
123L 1993-10-31 1.8 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
1LLH 2002-05-15 1.8 ARE CARBOXY TERMINII OF HELICES CODED BY THE LOCAL SEQUENCE OR BY TERTIARY STRUCTURE CONTACTS
1QSB 1999-07-07 1.8 THE INTRODUCTION OF STRAIN AND ITS EFFECTS ON THE STRUCTURE AND STABILITY OF T4 LYSOZYME
2HUL 2006-10-17 1.8 Crystal structure of T4 Lysozyme S44C synthetic dimer
1L43 1991-10-15 1.8 CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY
164L 1994-08-31 1.8 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
238L 1998-03-18 1.8 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
258L 2000-09-11 1.8 AN ADAPTABLE METAL-BINDING SITE ENGINEERED INTO T4 LYSOZYME
6LZM 1992-07-15 1.8 COMPARISON OF THE CRYSTAL STRUCTURE OF BACTERIOPHAGE T4 LYSOZYME AT LOW, MEDIUM, AND HIGH IONIC STRENGTHS
1L93 1993-10-31 1.8 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
1L35 1990-01-15 1.8 STRUCTURE OF A THERMOSTABLE DISULFIDE-BRIDGE MUTANT OF PHAGE T4 LYSOZYME SHOWS THAT AN ENGINEERED CROSSLINK IN A FLEXIBLE REGION DOES NOT INCREASE THE RIGIDITY OF THE FOLDED PROTEIN
3DN6 2008-11-11 1.8 1,3,5-trifluoro-2,4,6-trichlorobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant
1L56 1991-10-15 1.8 ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
187L 1995-07-10 1.8 SPECIFICITY OF LIGAND BINDING IN A BURIED NON-POLAR CAVITY OF T4 LYSOZYME: LINKAGE OF DYNAMICS AND STRUCTURAL PLASTICITY
1CVK 1999-11-10 1.8 T4 LYSOZYME MUTANT L118A
245L 1998-03-18 1.8 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
120L 1993-10-31 1.8 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
3G3X 2009-05-05 1.8 Crystal structure of spin labeled T4 Lysozyme (T151R1) at 100 K
118L 1993-10-31 1.8 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
1LYE 1993-10-31 1.8 DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO ACID SUBSTITUTIONS AT THR 59
3DN2 2008-11-11 1.8 Bromopentafluorobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant
3HTB 2009-11-03 1.81 2-propylphenol in complex with T4 lysozyme L99A/M102Q
2OTY 2007-08-07 1.83 1,2-dichlorobenzene in complex with T4 Lysozyme L99A
3C83 2009-02-17 1.84 Bacteriophage T4 lysozyme mutant D89A in wildtype background at room temperature
2RB0 2008-03-18 1.84 2,6-difluorobenzylbromide complex with T4 lysozyme L99A
1QT3 1999-07-08 1.85 T26D MUTANT OF T4 LYSOZYME
1L20 1990-01-15 1.85 ENHANCED PROTEIN THERMOSTABILITY FROM DESIGNED MUTATIONS THAT INTERACT WITH ALPHA-HELIX DIPOLES
3GUK 2009-08-25 1.85 T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--Toluene binding
1L39 1991-10-15 1.85 CONTRIBUTIONS OF ENGINEERED SURFACE SALT BRIDGES TO THE STABILITY OF T4 LYSOZYME DETERMINED BY DIRECTED MUTAGENESIS
1L88 1993-10-31 1.85 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
1L53 1991-10-15 1.85 STRUCTURAL AND THERMODYNAMIC ANALYSIS OF THE PACKING OF TWO ALPHA-HELICES IN BACTERIOPHAGE T4 LYSOZYME
1QUH 1999-07-08 1.85 L99G/E108V MUTANT OF T4 LYSOZYME
127L 1993-10-31 1.85 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
155L 1994-08-31 1.85 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
1L73 1991-10-15 1.85 MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
1QS9 1999-07-02 1.85 THE INTRODUCTION OF STRAIN AND ITS EFFECTS ON THE STRUCTURE AND STABILITY OF T4 LYSOZYME
1EPY 2000-04-12 1.85 T4 LYSOZYME MUTANT, T21H/C54T/C97A/Q141H/T142H
1G0K 2001-05-23 1.85 CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT T152C
1L37 1991-10-15 1.85 CONTRIBUTIONS OF ENGINEERED SURFACE SALT BRIDGES TO THE STABILITY OF T4 LYSOZYME DETERMINED BY DIRECTED MUTAGENESIS
137L 1994-07-31 1.85 STRUCTURAL BASIS OF AMINO ACID ALPHA HELIX PROPENSITY
157L 1994-08-31 1.85 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
146L 1994-01-31 1.85 ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4 LYSOZYME
1CU2 1999-11-10 1.85 T4 LYSOZYME MUTANT L84M
3C81 2009-02-17 1.85 Mutant K85A of T4 lysozyme in wildtype background at room temperature
1L40 1991-10-15 1.85 CONTRIBUTIONS OF ENGINEERED SURFACE SALT BRIDGES TO THE STABILITY OF T4 LYSOZYME DETERMINED BY DIRECTED MUTAGENESIS
125L 1993-10-31 1.85 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
3HTF 2009-11-03 1.85 4-chloro-1h-pyrazole in complex with T4 lysozyme L99A/M102Q
1L21 1990-01-15 1.85 CONTRIBUTIONS OF LEFT-HANDED HELICAL RESIDUES TO THE STRUCTURE AND STABILITY OF BACTERIOPHAGE T4 LYSOZYME
1L50 1991-10-15 1.85 STRUCTURAL AND THERMODYNAMIC ANALYSIS OF THE PACKING OF TWO ALPHA-HELICES IN BACTERIOPHAGE T4 LYSOZYME
224L 1994-01-31 1.85 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
1L72 1991-10-15 1.85 MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
109L 1993-10-31 1.85 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
1LGW 2002-05-08 1.85 T4 Lysozyme Mutant L99A/M102Q Bound by 2-fluoroaniline
1LI3 2002-05-08 1.85 T4 lysozyme mutant L99A/M102Q bound by 3-chlorophenol
1G06 2001-05-23 1.85 CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT V149S
220L 1998-03-18 1.85 GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS
1L71 1991-10-15 1.85 MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
199L 1996-03-08 1.85 THERMODYNAMIC AND STRUCTURAL COMPENSATION IN 'SIZE-SWITCH' CORE-REPACKING VARIANTS OF T4 LYSOZYME
3CDO 2009-02-17 1.87 Bacteriophage T4 lysozyme mutant R96V in wildtype background at low temperature
1CV5 1999-11-10 1.87 T4 LYSOZYME MUTANT L133M
214L 1996-12-23 1.89 PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
1KW7 2003-06-03 1.89 METHIONINE CORE MUTANT OF T4 LYSOZYME
1CUP 1999-11-10 1.89 METHIONINE CORE MUTANT OF T4 LYSOZYME
210L 1996-12-23 1.89 PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
1D2W 1999-10-08 1.89 N-TERMINAL DOMAIN CORE METHIONINE MUTATION
1DYA 1993-10-31 1.9 DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME
1L34 1990-01-15 1.9 HIGH-RESOLUTION STRUCTURE OF THE TEMPERATURE-SENSITIVE MUTANT OF PHAGE LYSOZYME, ARG 96 (RIGHT ARROW) HIS
1C6I 2000-10-04 1.9 T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 8 ATM ARGON
1DYF 1993-10-31 1.9 DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME
223L 1998-03-18 1.9 GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS
249L 1998-03-18 1.9 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
1L51 1991-10-15 1.9 STRUCTURAL AND THERMODYNAMIC ANALYSIS OF THE PACKING OF TWO ALPHA-HELICES IN BACTERIOPHAGE T4 LYSOZYME
1L28 1990-01-15 1.9 REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY
2O4W 2007-04-10 1.9 T4 lysozyme circular permutant
1I6S 2001-05-09 1.9 T4 LYSOZYME MUTANT C54T/C97A/N101A
1QT6 1999-07-08 1.9 E11H Mutant of T4 Lysozyme
234L 1998-01-14 1.9 T4 LYSOZYME MUTANT M106L
1CV6 1999-11-10 1.9 T4 LYSOZYME MUTANT V149M
1C6Q 2000-10-04 1.9 T4 LYSOZYME MUTANT C54T/C97A IN THE PRESENCE OF 8 ATM KRYPTON
1L55 1991-10-15 1.9 ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
1L69 1991-10-15 1.9 MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
3L64 2010-01-19 1.9 T4 Lysozyme S44E/WT*
1C6J 2000-10-04 1.9 T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 8 ATM KRYPTON
225L 1998-03-18 1.9 GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS
1C6G 2000-10-04 1.9 T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 4 ATM KRYPTON
1L89 1993-10-31 1.9 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
1QUG 1999-07-08 1.9 E108V MUTANT OF T4 LYSOZYME
1OWZ 2004-04-13 1.9 T4 Lysozyme Cavity Mutant L99A/M102Q Bound With 4-FluoroPhenEthyl Alcohol
172L 1995-07-10 1.9 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
1G0G 2001-05-23 1.9 CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT T152A
1L67 1991-10-15 1.9 TOLERANCE OF T4 LYSOZYME TO MULTIPLE XAA (RIGHT ARROW) ALA SUBSTITUTIONS: A POLYALANINE ALPHA-HELIX CONTAINING TEN CONSECUTIVE ALANINES
1LGX 2002-05-08 1.9 T4 Lysozyme Mutant L99A/M102Q Bound by 3,5-difluoroaniline
1L00 1993-10-31 1.9 PERTURBATION OF TRP 138 IN T4 LYSOZYME BY MUTATIONS AT GLN 105 USED TO CORRELATE CHANGES IN STRUCTURE, STABILITY, SOLVATION, AND SPECTROSCOPIC PROPERTIES
233L 1998-01-14 1.9 T4 LYSOZYME MUTANT M120L
1C6P 2000-10-04 1.9 T4 LYSOZYME MUTANT C54T/C97A IN THE PRESENCE OF 8 ATM ARGON
254L 1998-01-28 1.9 LYSOZYME
1G1V 2001-05-09 1.9 T4 LYSOZYME MUTANT C54T/C97A/I58T
1L75 1991-10-15 1.9 MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
4WTV 2015-07-15 1.9 Crystal structure of the phosphatidylinositol 4-kinase IIbeta
195L 1996-03-08 1.9 THERMODYNAMIC AND STRUCTURAL COMPENSATION IN 'SIZE-SWITCH' CORE-REPACKING VARIANTS OF T4 LYSOZYME
236L 1998-03-18 1.9 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
230L 1998-01-14 1.9 T4 LYSOZYME MUTANT M6L
1B6I 2000-01-12 1.9 T4 LYSOZYME MUTANT WITH CYS 54 REPLACED BY THR, CYS 97 REPLACED BY ALA, THR 21 REPLACED BY CYS AND LYS 124 REPLACED BY CYS (C54T,C97A,T21C,K124C)
1L64 1991-10-15 1.9 TOLERANCE OF T4 LYSOZYME TO MULTIPLE XAA (RIGHT ARROW) ALA SUBSTITUTIONS: A POLYALANINE ALPHA-HELIX CONTAINING TEN CONSECUTIVE ALANINES
1QTH 1999-07-22 1.9 THE INTRODUCTION OF STRAIN AND ITS EFFECTS ON THE STRUCTURE AND STABILITY OF T4 LYSOZYME
1OWY 2004-04-13 1.9 T4 Lysozyme Cavity Mutant L99A/M102Q Bound With 2-Propyl-Aniline
1L54 1991-10-15 1.9 THE STRUCTURAL AND THERMODYNAMIC CONSEQUENCES OF BURYING A CHARGED RESIDUE WITHIN THE HYDROPHOBIC CORE OF T4 LYSOZYME
222L 1998-03-18 1.9 GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS
1C6H 2000-10-04 1.9 T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 4 ATM XENON
1CV4 1999-11-10 1.9 T4 LYSOZYME MUTANT L118M
148L 1994-04-30 1.9 A COVALENT ENZYME-SUBSTRATE INTERMEDIATE WITH SACCHARIDE DISTORTION IN A MUTANT T4 LYSOZYME
192L 1995-09-15 1.9 A HELIX INITIATION SIGNAL IN T4 LYSOZYME IDENTIFIED BY POLYALANINE MUTAGENESIS
1PQJ 2003-10-07 1.9 T4 LYSOZYME CORE REPACKING MUTANT A111V/CORE10/TA
1L79 1993-04-15 1.9 DESIGN AND STRUCTURAL ANALYSIS OF ALTERNATIVE HYDROPHOBIC CORE PACKING ARRANGEMENTS IN BACTERIOPHAGE T4 LYSOZYME
1QTB 1999-07-02 1.9 THE INTRODUCTION OF STRAIN AND ITS EFFECTS ON THE STRUCTURE AND STABILITY OF T4 LYSOZYME
257L 2000-09-11 1.9 AN ADAPTABLE METAL-BINDING SITE ENGINEERED INTO T4 LYSOZYME
1C6L 2000-10-04 1.9 T4 LYSOZYME MUTANT C54T/C97A/L99A/F153A IN THE PRESENCE OF 8 ATM ARGON
228L 1998-03-18 1.9 GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS
1LGU 2002-05-08 1.9 T4 Lysozyme Mutant L99A/M102Q
1JTM 2002-03-20 1.9 Alternative Structures of a Sequence Extended T4 Lysozyme Show that the Highly Conserved Beta-Sheet has Weak Intrinsic Folding Propensity
1QT8 1999-07-08 1.9 T26H Mutant of T4 Lysozyme
1L70 1991-10-15 1.9 MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
1QSQ 1999-06-29 1.9 CAVITY CREATING MUTATION
1L57 1991-10-15 1.9 ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
248L 1998-03-18 1.9 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
1L76 1991-10-15 1.9 TOLERANCE OF T4 LYSOZYME TO PROLINE SUBSTITUTIONS WITHIN THE LONG INTERDOMAIN ALPHA-HELIX ILLUSTRATES THE ADAPTABILITY OF PROTEINS TO POTENTIALLY DESTABILIZING LESIONS
1C6K 2000-10-04 1.9 T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 8 ATM XENON
235L 1998-03-18 1.9 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
1C6E 2000-10-04 1.9 T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 2 ATM XENON
103L 1993-10-31 1.9 HOW AMINO-ACID INSERTIONS ARE ALLOWED IN AN ALPHA-HELIX OF T4 LYSOZYME
1L84 1993-10-31 1.9 A CAVITY-CONTAINING MUTANT OF T4 LYSOZYME IS STABILIZED BY BURIED BENZENE
1QUO 1999-07-08 1.9 L99A/E108V MUTANT OF T4 LYSOZYME
1D9W 1999-11-17 1.91 BACTERIOPHAGE T4 LYSOZYME MUTANT
259L 1999-04-12 1.92 AN ADAPTABLE METAL-BINDING SITE ENGINEERED INTO T4 LYSOZYME
1CX7 1999-11-10 1.94 T4 LYSOZYME METHIONINE CORE MUTANT
2OU0 2007-08-07 1.94 1-methylpyrrole in complex with T4 Lysozyme L99A
200L 1996-03-08 1.95 THERMODYNAMIC AND STRUCTURAL COMPENSATION IN 'SIZE-SWITCH' CORE-REPACKING VARIANTS OF T4 LYSOZYME
191L 1995-09-15 1.95 A HELIX INITIATION SIGNAL IN T4 LYSOZYME IDENTIFIED BY POLYALANINE MUTAGENESIS
3C7Y 2009-02-17 1.95 Mutant R96A OF T4 lysozyme in wildtype background at 298K
1L99 1993-10-31 1.95 PERTURBATION OF TRP 138 IN T4 LYSOZYME BY MUTATIONS AT GLN 105 USED TO CORRELATE CHANGES IN STRUCTURE, STABILITY, SOLVATION, AND SPECTROSCOPIC PROPERTIES
1OVH 2004-04-06 1.95 T4 Lysozyme Cavity Mutant L99A/M102Q Bound With 2-Chloro-6-Methyl-Aniline
215L 1996-12-23 1.96 PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
1D3J 1999-10-08 1.97 N-TERMINAL DOMAIN CORE METHIONINE MUTATION
1KY0 2003-06-03 1.97 METHIONINE CORE MUTANT OF T4 LYSOZYME
1L0J 2003-06-03 1.98 METHIONINE CORE MUTANT OF T4 LYSOZYME
3C80 2009-02-17 1.99 T4 Lysozyme mutant R96Y at room temperature
143L 1994-01-31 2.0 ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4 LYSOZYME
2HUK 2006-10-17 2.0 Crystal structure of T4 Lysozyme V131C synthetic dimer
1TLA 1993-07-15 2.0 HYDROPHOBIC CORE REPACKING AND AROMATIC-AROMATIC INTERACTION IN THE THERMOSTABLE MUTANT OF T4 LYSOZYME SER 117 (RIGHT ARROW) PHE
1L97 1993-10-31 2.0 STRUCTURE OF A HINGE-BENDING BACTERIOPHAGE T4 LYSOZYME MUTANT, ILE3-> PRO
1C64 2000-10-04 2.0 T4 LYSOZYME MUTANT C54T/C97A/L121A IN THE PRESENCE OF 8 ATM KRYPTON
1C6F 2000-10-04 2.0 T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 32 ATM ARGON
1LYI 1993-10-31 2.0 DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO ACID SUBSTITUTIONS AT THR 59
1LYD 1990-04-15 2.0 CRYSTAL STRUCTURE OF T4-LYSOZYME GENERATED FROM SYNTHETIC CODING DNA EXPRESSED IN ESCHERICHIA COLI
1C60 2000-10-04 2.0 T4 LYSOZYME MUTANT C54T/C97A/F153A IN THE PRESENCE OF 8 ATM ARGON
1LI2 2002-05-08 2.0 T4 Lysozyme Mutant L99A/M102Q Bound by Phenol
1LI6 2002-05-08 2.0 T4 lysozyme mutant L99A/M102Q bound by 5-methylpyrrole
5V83 2017-05-24 2.0 Structure of DCN1 bound to NAcM-HIT
190L 1995-09-15 2.0 A HELIX INITIATION SIGNAL IN T4 LYSOZYME IDENTIFIED BY POLYALANINE MUTAGENESIS
1PQK 2003-10-07 2.0 Repacking of the Core of T4 Lysozyme by Automated Design
1C6C 2000-10-04 2.0 T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 16 ATM ARGON
1L96 1993-10-31 2.0 STRUCTURE OF A HINGE-BENDING BACTERIOPHAGE T4 LYSOZYME MUTANT, ILE3-> PRO
1OV7 2004-04-06 2.0 T4 Lysozyme Cavity Mutant L99A/M102Q Bound with 2-Allyl-6-Methyl-Phenol
145L 1994-01-31 2.0 ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4 LYSOZYME
1C63 2000-10-04 2.0 T4 LYSOZYME MUTANT C54T/C97A/L121A IN THE PRESENCE OF 8 ATM ARGON
2L78 1993-04-15 2.0 DESIGN AND STRUCTURAL ANALYSIS OF ALTERNATIVE HYDROPHOBIC CORE PACKING ARRANGEMENTS IN BACTERIOPHAGE T4 LYSOZYME
1C6T 2000-10-04 2.0 T4 LYSOZYME MUTANT C54T/C97A IN THE PRESENCE OF 8 ATM XENON
152L 1994-05-31 2.0 CONSERVATION OF SOLVENT-BINDING SITES IN 10 CRYSTAL FORMS OF T4 LYSOZYME
1L95 1993-10-31 2.0 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
4YX7 2015-06-03 2.0 Complex of SpaO(SPOA1,2) and OrgB(APAR)::T4lysozyme fusion protein
147L 1994-01-31 2.0 ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4 LYSOZYME
253L 1998-01-28 2.0 LYSOZYME
1QTZ 1999-07-08 2.0 D20C MUTANT OF T4 LYSOZYME
141L 1994-01-31 2.0 ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4 LYSOZYME
198L 1996-03-08 2.0 THERMODYNAMIC AND STRUCTURAL COMPENSATION IN 'SIZE-SWITCH' CORE-REPACKING VARIANTS OF T4 LYSOZYME
1C65 2000-10-04 2.0 T4 LYSOZYME MUTANT C54T/C97A/L121A IN THE PRESENCE OF 8 ATM XENON
201L 1994-01-31 2.0 HOW AMINO-ACID INSERTIONS ARE ALLOWED IN AN ALPHA-HELIX OF T4 LYSOZYME
1L81 1993-04-15 2.0 DESIGN AND STRUCTURAL ANALYSIS OF ALTERNATIVE HYDROPHOBIC CORE PACKING ARRANGEMENTS IN BACTERIOPHAGE T4 LYSOZYME
1C6D 2000-10-04 2.0 T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 16 ATM KRYPTON
1D3N 1999-09-30 2.0 METHIONINE CORE MUTATION
1T8A 2004-08-17 2.0 USE OF SEQUENCE DUPLICATION TO ENGINEER A LIGAND-TRIGGERED LONG-DISTANCE MOLECULAR SWITCH IN T4 Lysozyme
1C61 2000-10-04 2.0 T4 LYSOZYME MUTANT C54T/C97A/F153A IN THE PRESENCE OF 8 ATM KRYPTON
1OVJ 2004-04-06 2.0 T4 Lysozyme Cavity Mutant L99A/M102Q Bound with 3-Fluoro-2-Methyl_Aniline
1L85 1993-10-31 2.0 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
227L 1998-03-18 2.0 GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS
3DMZ 2008-11-11 2.0 Hexafluorobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant
142L 1994-01-31 2.0 ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4 LYSOZYME
1T6H 2004-10-26 2.01 Crystal Structure T4 Lysozyme incorporating an unnatural amino acid p-iodo-L-phenylalanine at position 153
1CX6 1999-12-15 2.01 T4 LYSOZYME SUBSTITUTED WITH SELENOMETHIONINE
2OEA 2007-01-30 2.01 High-pressure structure of pseudo-WT T4 Lysozyme
2OE9 2007-01-30 2.01 High-pressure structure of pseudo-WT T4 Lysozyme
3HT9 2009-11-03 2.02 2-methoxyphenol in complex with T4 lysozyme L99A/M102Q
1L0K 2003-06-03 2.02 METHIONINE CORE MUTANT OF T4 LYSOZYME
1KY1 2003-06-03 2.05 METHIONINE CORE MUTANT OF T4 LYSOZYME
1CU5 1999-11-10 2.05 T4 LYSOZYME MUTANT L91M
1CUQ 1999-11-10 2.05 T4 LYSOZYME MUTANT V103M
1L77 1993-04-15 2.05 DESIGN AND STRUCTURAL ANALYSIS OF ALTERNATIVE HYDROPHOBIC CORE PACKING ARRANGEMENTS IN BACTERIOPHAGE T4 LYSOZYME
1D3F 1999-10-08 2.05 N-TERMINAL DOMAIN CORE METHIONINE MUTATION
218L 1996-12-23 2.05 PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
1D2Y 1999-10-08 2.06 N-TERMINAL DOMAIN CORE METHIONINE MUTATION
3GUL 2009-08-25 2.07 T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--ethylbenzene binding
2OTZ 2007-08-07 2.07 N-methylaniline in complex with T4 Lysozyme L99A
2B74 2005-11-08 2.1 T4 Lysozyme mutant L99A at 100 MPa
2B75 2005-11-08 2.1 T4 Lysozyme mutant L99A at 150 MPa
205L 1994-01-31 2.1 HOW AMINO-ACID INSERTIONS ARE ALLOWED IN AN ALPHA-HELIX OF T4 LYSOZYME
1L82 1993-04-15 2.1 DESIGN AND STRUCTURAL ANALYSIS OF ALTERNATIVE HYDROPHOBIC CORE PACKING ARRANGEMENTS IN BACTERIOPHAGE T4 LYSOZYME
2B72 2005-11-08 2.1 T4 Lysozyme mutant L99A at 100 MPa
2OE4 2007-01-30 2.1 High Pressure Psuedo Wild Type T4 Lysozyme
2OE7 2007-01-30 2.1 High-Pressure T4 Lysozyme
1OV5 2004-04-06 2.1 T4 Lysozyme Cavity Mutant L99a/M102Q Bound With 2-Allylphenol
1CU6 1999-11-17 2.1 T4 LYSOZYME MUTANT L91A
3G3V 2009-05-05 2.1 Crystal structure of spin labeled T4 Lysozyme (V131R1) at 291 K
1DYG 1993-10-31 2.1 DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME
144L 1994-01-31 2.1 ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4 LYSOZYME
2Q9E 2007-06-26 2.1 Structure of spin-labeled T4 lysozyme mutant S44R1
1OVK 2004-04-06 2.1 T4 Lysozyme Cavity Mutant L99A/M102Q Bound with N-Allyl-Aniline
197L 1996-03-08 2.1 THERMODYNAMIC AND STRUCTURAL COMPENSATION IN 'SIZE-SWITCH' CORE-REPACKING VARIANTS OF T4 LYSOZYME
1CTW 1999-11-10 2.1 T4 LYSOZYME MUTANT I78A
140L 1994-01-31 2.1 ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4 LYSOZYME
1QT4 1999-07-08 2.1 T26Q MUTANT OF T4 LYSOZYME
1CV1 1999-11-10 2.1 T4 LYSOZYME MUTANT V111M
252L 1998-03-18 2.1 GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS
1LWK 2003-05-20 2.1 Multiple Methionine Substitutions are Tolerated in T4 Lysozyme and have Coupled Effects on Folding and Stability
1DYC 1993-10-31 2.1 DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME
216L 1994-07-31 2.1 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
1DYD 1993-10-31 2.1 DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME
175L 1995-07-10 2.1 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
1C6A 2000-10-04 2.1 T4 LYSOZYME MUTANT C54T/C97A/L133A IN THE PRESENCE OF 8 ATM KRYPTON
2B6T 2005-11-08 2.1 T4 Lysozyme mutant L99A at 200 MPa
1C6M 2000-10-04 2.1 T4 LYSOZYME MUTANT C54T/C97A/L99A/F153A IN THE PRESENCE OF 8 ATM KRYPTON
1C66 2000-10-04 2.1 T4 LYSOZYME MUTANT C54T/C97A/L121A/L133A IN THE PRESENCE OF 8 ATM ARGON
2B6X 2005-11-08 2.11 T4 Lysozyme mutant L99A at 200 MPa
4S0W 2015-02-04 2.12 Wild type T4 lysozyme structure
1CV0 1999-11-10 2.12 T4 LYSOZYME MUTANT F104M
1CU3 1999-11-10 2.12 T4 LYSOZYME MUTANT V87M
1D3M 1999-09-30 2.12 METHIONINE CORE MUTATION
213L 1996-12-23 2.13 PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
1SSW 2004-10-19 2.13 Crystal structure of phage T4 lysozyme mutant Y24A/Y25A/T26A/I27A/C54T/C97A
1T8F 2004-10-19 2.15 Crystal structure of phage T4 lysozyme mutant R14A/K16A/I17A/K19A/T21A/E22A/C54T/C97A
2B73 2005-11-08 2.15 T4 Lysozyme mutant L99A at 100 MPa
1KS3 2003-06-03 2.16 METHIONINE CORE MUTANT OF T4 LYSOZYME
3GUO 2009-08-25 2.16 T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--phenol binding
176L 1995-07-10 2.2 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
3VW7 2012-12-12 2.2 Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom
1CU0 1999-11-10 2.2 T4 LYSOZYME MUTANT I78M
1C6N 2000-10-04 2.2 T4 LYSOZYME MUTANT C54T/C97A/L99A/F153A IN THE PRESENCE OF 8 ATM XENON
5TZR 2017-06-07 2.2 GPR40 in complex with partial agonist MK-8666
1C6B 2000-10-04 2.2 T4 LYSOZYME MUTANT C54T/C97A/L133A IN THE PRESENCE OF 8 ATM XENON
167L 1995-07-10 2.2 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
150L 1994-04-30 2.2 CONSERVATION OF SOLVENT-BINDING SITES IN 10 CRYSTAL FORMS OF T4 LYSOZYME
5X93 2017-08-16 2.2 Human endothelin receptor type-B in complex with antagonist K-8794
151L 1994-04-30 2.2 CONSERVATION OF SOLVENT-BINDING SITES IN 10 CRYSTAL FORMS OF T4 LYSOZYME
1C67 2000-10-04 2.2 T4 LYSOZYME MUTANT C54T/C97A/L121A/L133A IN THE PRESENCE OF 8 ATM KRYPTON
2B6W 2005-11-08 2.2 T4 Lysozyme mutant L99A at 200 MPa
6FFI 2018-03-07 2.2 Crystal Structure of mGluR5 in complex with MMPEP at 2.2 A
5VNQ 2017-07-26 2.2 Neutron crystallographic strucutre of perdeuterated T4 lysozyme cysteine-free pseudo-wild type at cryogenic temperature
3GUM 2009-08-25 2.24 T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--p-xylene binding
5VBA 2017-07-05 2.27 Structure of EspG1 chaperone from the type VII (ESX-1) secretion system determined with the assistance of N-terminal T4 lysozyme fusion
174L 1995-07-10 2.3 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
196L 1996-03-08 2.3 THERMODYNAMIC AND STRUCTURAL COMPENSATION IN 'SIZE-SWITCH' CORE-REPACKING VARIANTS OF T4 LYSOZYME
1QTV 1999-07-08 2.3 T26E APO STRUCTURE OF T4 LYSOZYME
1C62 2000-10-04 2.3 T4 LYSOZYME MUTANT C54T/C97A/F153A IN THE PRESENCE OF 8 ATM XENON
3G3W 2009-05-05 2.3 Crystal structure of spin labeled T4 Lysozyme (T151R1) at 291 K
1JTN 2002-03-20 2.3 Alternative Structures of a Sequence Extended T4 Lysozyme Show that the Highly Conserved Beta-Sheet Region has weak intrinsic Folding Propensity
4IAP 2013-07-31 2.3 Crystal structure of PH domain of Osh3 from Saccharomyces cerevisiae
4PHU 2014-07-16 2.33 Crystal structure of Human GPR40 bound to allosteric agonist TAK-875
4YXA 2015-06-03 2.35 Complex of SpaO(SPOA1,2 SeMet) and OrgB(APAR)::T4lysozyme fusion protein
2HUM 2006-10-17 2.35 Crystal structure of T4 Lysozyme D72C synthetic dimer
2B70 2005-11-08 2.4 T4 Lysozyme mutant L99A at ambient pressure
2B6Y 2005-11-08 2.4 T4 Lysozyme mutant L99A at ambient pressure
2QAR 2008-01-15 2.4 Structure of the 2TEL crystallization module fused to T4 lysozyme with a helical linker.
1SSY 2004-10-19 2.4 Crystal structure of phage T4 lysozyme mutant G28A/I29A/G30A/C54T/C97A
5YQR 2018-01-31 2.4 Crystal structure of the PH-like domain of Lam6
2B6Z 2005-11-08 2.4 T4 Lysozyme mutant L99A at ambient pressure
2RH1 2007-10-30 2.4 High resolution crystal structure of human B2-adrenergic G protein-coupled receptor.
3SB9 2011-09-21 2.45 Cu-mediated Dimer of T4 Lysozyme R76H/R80H by Synthetic Symmetrization
3SB5 2011-09-21 2.46 Zn-mediated Trimer of T4 Lysozyme R125C/E128C by Synthetic Symmetrization
5D5A 2016-01-13 2.48 In meso in situ serial X-ray crystallography structure of the Beta2-adrenergic receptor at 100 K
261L 1999-05-24 2.5 STRUCTURAL CHARACTERISATION OF AN ENGINEERED TANDEM REPEAT CONTRASTS THE IMPORTANCE OF CONTEXT AND SEQUENCE IN PROTEIN FOLDING
231L 1998-01-14 2.5 T4 LYSOZYME MUTANT M106K
5GLI 2016-09-07 2.5 Human endothelin receptor type-B in the ligand-free form
6M9T 2018-12-05 2.5 Crystal structure of EP3 receptor bound to misoprostol-FA
262L 1999-05-24 2.5 STRUCTURAL CHARACTERISATION OF AN ENGINEERED TANDEM REPEAT CONTRASTS THE IMPORTANCE OF CONTEXT AND SEQUENCE IN PROTEIN FOLDING
1QTC 1999-07-22 2.5 THE INTRODUCTION OF STRAIN AND ITS EFFECTS ON THE STRUCTURE AND STABILITY OF T4 LYSOZYME
1QS5 1999-07-02 2.5 THE INTRODUCTION OF STRAIN AND ITS EFFECTS ON THE STRUCTURE AND STABILITY OF T4 LYSOZYME
5EE7 2016-04-20 2.5 Crystal structure of the human glucagon receptor (GCGR) in complex with the antagonist MK-0893
171L 1995-07-10 2.5 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
177L 1995-07-10 2.5 Protein flexibility and adaptability seen in 25 crystal forms of T4 LYSOZYME
1QTD 1999-07-22 2.5 THE INTRODUCTION OF STRAIN AND ITS EFFECTS ON THE STRUCTURE AND STABILITY OF T4 LYSOZYME
1OYU 2003-07-08 2.5 Long-Distance conformational changes in a protein engineered by modulated sequence duplication
3ODU 2010-10-27 2.5 The 2.5 A structure of the CXCR4 chemokine receptor in complex with small molecule antagonist IT1t
189L 1995-07-31 2.5 ENHANCEMENT OF PROTEIN STABILITY BY THE COMBINATION OF POINT MUTATIONS IN T4 LYSOZYME IS ADDITIVE
1C68 2000-10-04 2.5 T4 LYSOZYME MUTANT C54T/C97A/L121A/L133A IN THE PRESENCE OF 8 ATM XENON
1P5C 2004-05-04 2.5 Circular permutation of Helix A in T4 lysozyme
2QB0 2008-10-14 2.56 Structure of the 2TEL crystallization module fused to T4 lysozyme with an Ala-Gly-Pro linker.
4ARJ 2012-05-09 2.59 Crystal structure of a pesticin (translocation and receptor binding domain) from Y. pestis and T4-lysozyme chimera
4XES 2015-07-29 2.6 Structure of active-like neurotensin receptor
170L 1995-07-10 2.6 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
4EXM 2012-06-20 2.6 The crystal structure of an engineered phage lysin containing the binding domain of pesticin and the killing domain of T4-lysozyme
4OO9 2014-07-02 2.6 Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator mavoglurant
5EWX 2016-03-30 2.6 Fusion protein of T4 lysozyme and B4 domain of protein A from staphylococcal aureus with chemical cross-linker EY-CBS
5WF5 2018-02-21 2.6 Agonist bound human A2a adenosine receptor with D52N mutation at 2.60 A resolution
149L 1994-04-30 2.6 CONSERVATION OF SOLVENT-BINDING SITES IN 10 CRYSTAL FORMS OF T4 LYSOZYME
1JQU 2002-03-06 2.6 Are Carboxy Terminii of Helices Coded by the Local Sequence or by Tertiary Structure Contacts
251L 1998-03-18 2.6 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
3EML 2008-10-14 2.6 The 2.6 A Crystal Structure of a Human A2A Adenosine Receptor bound to ZM241385.
5CGD 2015-08-12 2.6 Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile - (HTL14242)
5DSG 2016-03-16 2.6 Structure of the M4 muscarinic acetylcholine receptor (M4-mT4L) bound to tiotropium
3SB8 2011-09-21 2.65 Cu-mediated Dimer of T4 Lysozyme D61H/K65H by Synthetic Symmetrization
5JEA 2016-07-13 2.65 Structure of a cytoplasmic 11-subunit RNA exosome complex including Ski7, bound to RNA
6FFH 2018-03-07 2.65 Crystal Structure of mGluR5 in complex with Fenobam at 2.65 A
6K1Q 2019-07-17 2.7 Human endothelin receptor type-B in complex with inverse agonist IRL2500
5ZBQ 2018-04-25 2.7 The Crystal Structure of human neuropeptide Y Y1 receptor with UR-MK299
6J20 2019-03-06 2.7 Crystal structure of the human NK1 substance P receptor
3SB7 2011-09-21 2.7 Cu-mediated Trimer of T4 Lysozyme D61H/K65H/R76H/R80H by Synthetic Symmetrization
6A9J 2019-03-20 2.7 Crystal structure of the PE-bound N-terminal domain of Atg2
3SB6 2011-09-21 2.7 Cu-mediated Dimer of T4 Lysozyme D61H/K65H/R76H/R80H by Synthetic Symmetrization
5VEW 2017-05-24 2.7 Structure of the human GLP-1 receptor complex with PF-06372222
5X7D 2017-08-16 2.7 Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist
5CXV 2016-03-09 2.7 Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium
1T97 2004-08-17 2.7 Use of sequence duplication to engineer a ligand-triggered long-distance molecular switch in T4 Lysozyme
209L 1996-12-23 2.7 PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
178L 1995-07-10 2.71 Protein flexibility and adaptability seen in 25 crystal forms of T4 LYSOZYME
3QAK 2011-03-09 2.71 Agonist bound structure of the human adenosine A2a receptor
6D27 2018-10-03 2.74 Crystal structure of the prostaglandin D2 receptor CRTH2 with CAY10471
3SBA 2011-09-21 2.75 Zn-mediated Hexamer of T4 Lysozyme R76H/R80H by Synthetic Symmetrization
5KW2 2018-05-02 2.76 The extra-helical binding site of GPR40 and the structural basis for allosteric agonism and incretin stimulation
4LDE 2013-09-25 2.79 Structure of beta2 adrenoceptor bound to BI167107 and an engineered nanobody
104L 1993-10-31 2.8 HOW AMINO-ACID INSERTIONS ARE ALLOWED IN AN ALPHA-HELIX OF T4 LYSOZYME
4DKL 2012-03-21 2.8 Crystal structure of the mu-opioid receptor bound to a morphinan antagonist
4GRV 2012-10-17 2.8 The crystal structure of the neurotensin receptor NTS1 in complex with neurotensin (8-13)
6D26 2018-10-03 2.8 Crystal structure of the prostaglandin D2 receptor CRTH2 with fevipiprant
3V2Y 2012-02-15 2.8 Crystal Structure of a Lipid G protein-Coupled Receptor at 2.80A
5GLH 2016-09-07 2.8 Human endothelin receptor type-B in complex with ET-1
3D4S 2008-06-17 2.8 Cholesterol bound form of human beta2 adrenergic receptor.
5EUT 2015-12-23 2.8 Crystal structure of phosphatidyl inositol 4-kinase II alpha in the apo state
5NDD 2017-05-03 2.8 Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in complex with AZ8838 at 2.8 angstrom resolution
5T1A 2016-12-14 2.81 Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists
3NY8 2010-08-11 2.84 Crystal structure of the human beta2 adrenergic receptor in complex with the inverse agonist ICI 118,551
3NY9 2010-08-11 2.84 Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist
6CM4 2018-03-14 2.87 Structure of the D2 Dopamine Receptor Bound to the Atypical Antipsychotic Drug Risperidone
3PBL 2010-11-03 2.89 Structure of the human dopamine D3 receptor in complex with eticlopride
4DJH 2012-03-21 2.9 Structure of the human kappa opioid receptor in complex with JDTic
5WF6 2018-02-21 2.9 Agonist bound human A2a adenosine receptor with S91A mutation at 2.90 A resolution
168L 1995-07-10 2.9 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
4N9N 2014-12-03 2.9 Crystal Structure of Saccharomyces cerevisiae Upc2 Transcription Factor fused with T4 Lysozyme
4XEE 2015-07-29 2.9 Structure of active-like neurotensin receptor
3OE0 2010-10-27 2.9 Crystal structure of the CXCR4 chemokine receptor in complex with a cyclic peptide antagonist CVX15
5ZKQ 2018-06-20 2.9 Crystal structure of the human platelet-activating factor receptor in complex with ABT-491
6MXT 2018-11-14 2.96 Crystal structure of human beta2 adrenergic receptor bound to salmeterol and Nb71
4K5Y 2013-07-17 2.98 Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395
2B7X 2006-08-01 3.0 Sequential reorganization of beta-sheet topology by insertion of a single strand
5ZBH 2018-04-25 3.0 The Crystal Structure of Human Neuropeptide Y Y1 Receptor with BMS-193885
3JR6 2009-10-20 3.0 Sequential reorganization of beta-sheet topology by insertion of a single strand
5XEZ 2017-05-24 3.0 Structure of the Full-length glucagon class B G protein-coupled receptor
3UON 2012-02-01 3.0 Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
5VEX 2017-05-17 3.0 Structure of the human GLP-1 receptor complex with NNC0640
5YQZ 2018-01-17 3.0 Structure of the glucagon receptor in complex with a glucagon analogue
169L 1995-07-10 3.0 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
5W0P 2017-08-09 3.01 Crystal structure of rhodopsin bound to visual arrestin determined by X-ray free electron laser
4RWS 2015-02-11 3.1 Crystal structure of CXCR4 and viral chemokine antagonist vMIP-II complex (PSI Community Target)
4LDL 2013-09-25 3.1 Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody
5ZHP 2018-11-28 3.1 M3 muscarinic acetylcholine receptor in complex with a selective antagonist
3OE8 2010-10-27 3.1 Crystal structure of the CXCR4 chemokine receptor in complex with a small molecule antagonist IT1t in P1 spacegroup
3OE9 2010-10-27 3.1 Crystal structure of the chemokine CXCR4 receptor in complex with a small molecule antagonist IT1t in P1 spacegroup
5CGC 2015-08-12 3.1 Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-4-fluoro-5-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile
3RZE 2011-06-15 3.1 Structure of the human histamine H1 receptor in complex with doxepin
3NYA 2010-08-11 3.16 Crystal structure of the human beta2 adrenergic receptor in complex with the neutral antagonist alprenolol
5XF1 2017-05-24 3.19 Structure of the Full-length glucagon class B G protein-coupled receptor
3SN6 2011-07-20 3.2 Crystal structure of the beta2 adrenergic receptor-Gs protein complex
6A9E 2019-03-20 3.2 Crystal structure of the N-terminal domain of Atg2
6J21 2019-03-06 3.2 Crystal structure of the human NK1 substance P receptor
4LDO 2013-09-25 3.2 Structure of beta2 adrenoceptor bound to adrenaline and an engineered nanobody
3OE6 2010-10-27 3.2 Crystal structure of the CXCR4 chemokine receptor in complex with a small molecule antagonist IT1t in I222 spacegroup
5JQH 2016-07-13 3.2 Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60
5XSZ 2017-08-16 3.2 Crystal structure of zebrafish lysophosphatidic acid receptor LPA6
4TN3 2014-07-16 3.2 Structure of the BBox-Coiled-coil region of Rhesus Trim5alpha
5D6L 2016-08-17 3.2 beta2AR-T4L - CIM
5TZY 2017-06-07 3.22 GPR40 in complex with AgoPAM AP8 and partial agonist MK-8666
5T04 2016-12-21 3.3 STRUCTURE OF CONSTITUTIVELY ACTIVE NEUROTENSIN RECEPTOR
4ZWJ 2015-07-29 3.3 Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
4QKX 2014-07-23 3.3 Structure of beta2 adrenoceptor bound to a covalent agonist and an engineered nanobody
3V2W 2012-02-15 3.35 Crystal Structure of a Lipid G protein-Coupled Receptor at 3.35A
4DAJ 2012-02-22 3.4 Structure of the M3 Muscarinic Acetylcholine Receptor
4EJ4 2012-05-16 3.4 Structure of the delta opioid receptor bound to naltrindole
3P0G 2011-01-19 3.5 Structure of a nanobody-stabilized active state of the beta2 adrenoceptor
3PDS 2011-01-12 3.5 Irreversible Agonist-Beta2 Adrenoceptor Complex
5B2G 2016-10-05 3.5 Crystal structure of human claudin-4 in complex with C-terminal fragment of Clostridium perfringens enterotoxin
4W8F 2014-11-12 3.54 Crystal structure of the dynein motor domain in the AMPPNP-bound state
4U14 2014-11-26 3.57 Structure of the M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized T4 lysozyme (dsT4L)
5XPR 2017-08-16 3.6 Human endothelin receptor type-B in complex with antagonist bosentan
5NDZ 2017-05-03 3.6 Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in complex with AZ3451 at 3.6 angstrom resolution
5D5B 2016-01-13 3.8 In meso X-ray crystallography structure of the Beta2-adrenergic receptor at 100 K
4GBR 2012-10-24 3.99 N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor
4HTT 2013-05-01 6.8 Crystal Structure of Twin Arginine Translocase Receptor- TatC in DDM
5DGY 2016-03-23 7.7 Crystal structure of rhodopsin bound to visual arrestin

Relevant UniProtKB Entries

Percent Identity Matching Chains Protein Accession Entry Name
100.0 Endolysin P00720 ENLYS_BPT4