Thermodynamic stability of carbonic anhydrase: measurements of binding affinity and stoichiometry using ThermoFluor.


Abstract

ThermoFluor (a miniaturized high-throughput protein stability assay) was used to analyze the linkage between protein thermal stability and ligand binding. Equilibrium binding ligands increase protein thermal stability by an amount proportional to the concentration and affinity of the ligand. Binding constants (K(b)) were measured by examining the systematic effect of ligand concentration on protein stability. The precise ligand effects depend on the thermodynamics of protein stability: in particular, the unfolding enthalpy. An extension of current theoretical treatments was developed for tight binding inhibitors, where ligand effect on T(m) can also reveal binding stoichiometry. A thermodynamic analysis of carbonic anhydrase by differential scanning calorimetry (DSC) enabled a dissection of the Gibbs free energy of stability into enthalpic and entropic components. Under certain conditions, thermal stability increased by over 30 degrees C; the heat capacity of protein unfolding was estimated from the dependence of calorimetric enthalpy on T(m). The binding affinity of six sulfonamide inhibitors to two isozymes (human type 1 and bovine type 2) was analyzed by both ThermoFluor and isothermal titration calorimetry (ITC), resulting in a good correlation in the rank ordering of ligand affinity. This combined investigation by ThermoFluor, ITC, and DSC provides a detailed picture of the linkage between ligand binding and protein stability. The systematic effect of ligands on stability is shown to be a general tool to measure affinity. Study holds ProTherm entries: 19164, 19165, 19166, 19167, 19168 Extra Details: 0.5 mM EDTA, 50 microM ANS and 100 microM ACTAZ were added in the experiment. ligand binding; binding constants; enthalpic; entropic

Submission Details

ID: fC2H84q5

Submitter: Connie Wang

Submission Date: April 24, 2018, 8:51 p.m.

Version: 1

Publication Details
Matulis D;Kranz JK;Salemme FR;Todd MJ,Biochemistry (2005) Thermodynamic stability of carbonic anhydrase: measurements of binding affinity and stoichiometry using ThermoFluor. PMID:15794662
Additional Information

Structure view and single mutant data analysis

Study data

No weblogo for data of varying length.
Colors: D E R H K S T N Q A V I L M F Y W C G P
 

Data Distribution

Studies with similar sequences (approximate matches)

Correlation with other assays (exact sequence matches)


Relevant PDB Entries

Structure ID Release Date Resolution Structure Title
6FJJ 2019-02-06 Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (saccharin).
5C8I 2016-07-20 Joint X-ray/neutron structure of Human Carbonic Anhydrase II in complex with Methazolamide
6FJI 2019-02-06 Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (apo).
6QEB 2019-02-06 Assessment of a large enzyme-drug complex by proton-detected solid-state NMR without deuteration
6GCY 2019-02-06 Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (saccharin-sugar conjugate complex)
6BC9 2018-02-28 Joint X-ray/neutron structure of human carbonic anhydrase II in complex with dorzolamide
3KS3 2010-01-26 0.9 High resolution structure of Human Carbonic Anhydrase II at 0.9 A
6B00 2017-12-13 0.9 Thermostabilized mutant of human carbonic anhydrase II - A65T L100H K154N L224S L240P A248T
3K34 2010-05-12 0.9 Human carbonic anhydrase II with a sulfonamide inhibitor
5Y2S 2018-02-14 0.9 7.0 atm CO2-pressurized human carbonic anhydrase II
3U7C 2013-02-13 0.93 crystal structure of the V143I mutant of human carbonic anhydrase II
1LUG 2003-09-09 0.95 Full Matrix Error Analysis of Carbonic Anhydrase
4YXI 2016-02-03 0.96 Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (2).
4FU5 2013-07-17 0.98 Carbonic Anhydrase II in complex with N-[(2Z)-1,3-oxazolidin-2-ylidene]sulfuric diamide
4FPT 2013-07-03 0.98 Carbonic Anhydrase II in complex with ethyl (2Z,4R)-2-(sulfamoylimino)-1,3-thiazolidine-4-carboxylate
4FRC 2013-07-17 0.98 Carbonic Anhydrase II in complex with N'-sulfamoylpyrrolidine-1-carboximidamide
2FOU 2006-04-04 0.99 Human Carbonic Anhydrase II complexed with two-prong inhibitors
5OGO 2018-08-01 0.99 Crystal structure of chimeric carbonic anhydrase I with 3-(Benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
5LJT 2017-06-21 1.0 Crystal structure of human carbonic anhydrase II in complex with the 4-((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)benzenesulfonamide inhibitor
5Y2R 2018-02-14 1.0 2.5 atm CO2-pressurized human carbonic anhydrase II
4MTY 2013-12-11 1.0 Structure at 1A resolution of a helical aromatic foldamer-protein complex.
4Q78 2015-03-18 1.0 Structure-assisted design of carborane-based inhibitors of carbonic anhydrase
2NNO 2007-05-08 1.01 Structure of inhibitor binding to Carbonic Anhydrase II
6G3Q 2018-11-28 1.01 Crystal structure of human carbonic anhydrase II in complex with the inhibitor famotidine
4YX4 2016-02-03 1.01 Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (1).
5LL8 2017-08-16 1.03 Human Carbonic Anhydrase II in complex with aliphatic Benzenesulfonamide inhibitor.
3V7X 2012-04-04 1.03 Complex of human carbonic anhydrase II with N-[2-(3,4-dimethoxyphenyl)ethyl]-4-sulfamoylbenzamide
2NNS 2007-05-08 1.03 Structure of inhibitor binding to Carbonic Anhydrase II
2ILI 2007-06-05 1.05 Refine atomic structure of human carbonic anhydrase II
5DOH 2016-09-28 1.05 Crystal structure of human carbonic anhydrase isozyme II with 2-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-3,5,6-trifluoro-4-[(2-hydroxyethyl)thio]benzenesulfonamide
5LJQ 2017-06-21 1.05 Crystal structure of human carbonic anhydrase II in complex with the 4-(4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl)benzenesulfonamide inhibitor
3VBD 2012-04-04 1.05 Complex of human carbonic anhydrase II with 4-(6-methoxy-3,4-dihydroisoquinolin-1-yl)benzenesulfonamide
1MOO 2002-09-18 1.05 Site Specific Mutant (H64A) of Human Carbonic Anhydrase II at high resolution
4FVN 2013-07-17 1.05 Carbonic Anhydrase II in complex with N-(tetrahydropyrimidin-2(1H)-ylidene)sulfuric diamide
4FVO 2013-07-03 1.05 Carbonic Anhydrase II in complex with N-[(2E)-3,4-dihydroquinazolin-2(1H)-ylidene]sulfuric diamide
4YXO 2016-02-03 1.06 Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (3).
4PZH 2015-01-28 1.06 Crystal structure of human carbonic anhydrase isozyme II with 2,3,5,6-tetrafluoro-4[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
4WW6 2015-07-01 1.06 Crystal structure of human carbonic anhydrase isozyme II with 2,3,5,6-Tetrafluoro-4-(propylthio)benzenesulfonamide
4YYT 2016-02-03 1.07 Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (5).
4Q08 2015-01-28 1.07 Crystal structure of chimeric carbonic anhydrase XII with inhibitor
5M78 2017-12-20 1.08 Human Carbonic Anhydrase II in complex with fragment-like inhibitor.
4YXU 2016-02-03 1.08 Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (4).
6GDC 2019-05-01 1.08 Human Carbonic Anhydrase II in complex with Benzenesulfonamide
6GM9 2019-06-19 1.09 Human Carbonic Anhydrase II in complex with 4-Methylbenzenesulfonamide
2WEG 2009-11-10 1.1 Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors
5OGP 2018-08-01 1.1 Metalacarborane inhibitors of Carbonic Anhydrase IX
2NNV 2007-05-08 1.1 Structure of inhibitor binding to Carbonic Anhydrase II
3D93 2008-09-02 1.1 Apo Human carbonic anhydrase II bound with substrate carbon dioxide
2FOS 2006-04-04 1.1 Human Carbonic Anhydrase II complexed with two-prong inhibitors
5JGT 2017-01-11 1.1 Human carbonic anhydrase II (F131Y/L198A) complexed with 1,3-thiazole-2-sulfonamide
3HS4 2009-12-08 1.1 Human carbonic anhydrase II complexed with acetazolamide
5OGN 2018-08-01 1.1 Metalacarborane inhibitors of Carbonic Anhydrase IX
5NXW 2018-01-17 1.1 Carbonic Anhydrase II Inhibitor RA9
4WL4 2015-10-14 1.1 Crystal structure of human carbonic anhydrase II in complex with the 6-hydroxy-chromene-2-thione inhibitor
3SAX 2012-04-11 1.1 Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-{[(5-ethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide
3D92 2008-09-02 1.1 Human carbonic anhydrase II bound with substrate carbon dioxide
5NXV 2018-01-17 1.1 Carbonic Anhydrase II Inhibitor RA8
5NY1 2018-01-17 1.1 Carbonic Anhydrase II Inhibitor RA10
5NY6 2018-01-17 1.1 Carbonic Anhydrase II Inhibitor RA12
4YGJ 2015-03-25 1.1 NaBr--Interactions between Hofmeister Anions and the Binding Pocket of a Protein
5LLC 2017-08-16 1.1 Crystal structure of human carbonic anhydrase isozyme II with 3-(Methylamino)-2,5,6-trifluoro-4-[(2-phenylethyl)sulfonyl]benzenesulfonamide
5DRS 2016-09-28 1.1 Crystal structure of human carbonic anhydraseisozyme II with 3-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
5JGS 2017-01-11 1.11 Human carbonic anhydrase II (F131Y/L198A) complexed with benzo[d]thiazole-2-sulfonamide
5LLG 2017-08-16 1.12 Crystal structure of human carbonic anhydrase isozyme II with 4-Propylthiobenzenesulfonamide
4Q6D 2014-11-26 1.12 Crystal structure of human carbonic anhydrase isozyme II with 4-[(Z)-azepan-1-yldiazenyl]benzenesulfonamide
5LL4 2017-08-16 1.12 Crystal structure of human carbonic anhydrase isozyme II with 4-(1H-benzimidazol-1-ylacetyl)benzenesulfonamide
4Q6E 2014-11-26 1.12 Crystal structure of human carbonic anhydrase isozyme II with 4-{[3-(3,5-Dimethyl-1H-pyrazol-1-yl)-3-oxopropyl]amino}benzene-1-sulfonamide
6G6T 2019-03-13 1.12 Crystal structure of human carbonic anhydrase isozyme II with N-butyl-2,4-dichloro-5-sulfamoyl-benzamide
5EKJ 2016-01-06 1.13 Human Carbonic Anhydrase II complexed with a two-faced guest
5JEH 2017-01-11 1.13 Human carbonic anhydrase II (L198A) complexed with benzo[d]thiazole-2-sulfonamide
4RUY 2015-04-22 1.14 Crystal structure of human Carbonic Anhydrase II in complex with 4-propoxybenzenesulfonamide
4RUX 2015-04-22 1.14 Crystal structure of human Carbonic Anhydrase II in complex with 4-(allyloxy)benzenesulfonamide
3MHO 2010-10-20 1.15 Crystal structure of human carbonic anhydrase isozyme II with 4-[N-(6-chloro-5-formyl-2-methylthiopyrimidin-4-yl)amino]benzenesulfonamide
4Q06 2015-01-28 1.15 Crystal structure of chimeric carbonic anhydrase IX with inhibitor
5BYI 2015-08-05 1.15 Human carbonic anhydrase II with an azobenzene inhibitor (1d)
5SZ6 2016-12-28 1.15 Carbonic anhydrase IX-mimic in complex with 4-(3-formylphenyl)-benzenesulfonamide
2FOV 2006-04-04 1.15 Human Carbonic Anhydrase II complexed with two-prong inhibitors
2EU2 2006-07-11 1.15 Human Carbonic Anhydrase II in complex with novel inhibitors
4Q07 2015-01-28 1.15 Crystal structure of chimeric carbonic anhydrase IX with inhibitor
5JE7 2017-01-11 1.15 Human carbonic anhydrase II (F131Y) complexed with benzo[d]thiazole-2-sulfonamide
2NXT 2007-04-24 1.15 Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II
6IC2 2019-05-15 1.15 Polypharmacology of Epacadostat: a Potent and Selective Inhibitor of the Tumor Associated Carbonic Anhydrases IX and XII
4HF3 2013-10-23 1.15 Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
5NXI 2018-01-17 1.16 Carbonic Anhydrase II Inhibitor RA2
3RYY 2011-08-10 1.16 Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
4ITO 2014-03-26 1.16 Human CA II inhibition by novel sulfonamide
3M2Y 2011-05-25 1.17 Carbonic Anhydrase II in complex with novel sulfonamide inhibitor
5MJN 2017-12-06 1.17 Three dimensional structure of human carbonic anhydrase II in complex with 5-[(4Chlorobenzyl)sulfanyl]thiophene-2-sulfonamide
5JEG 2017-01-11 1.19 Human carbonic anhydrase II (V121I) complexed with benzo[d]thiazole-2-sulfonamide
5JEP 2017-01-11 1.19 Human carbonic anhydrase II (T199S) complexed with benzo[d]thiazole-2-sulfonamide
5JG5 2017-01-11 1.19 Human carbonic anhydrase II (V121T/F131Y) complexed with benzo[d]thiazole-2-sulfonamide
2NNG 2007-05-08 1.2 Structure of inhibitor binding to Carbonic Anhydrase II
3RYV 2011-08-10 1.2 Carbonic Anhydrase complexed with N-ethyl-4-sulfamoylbenzamide
5YUI 2018-08-01 1.2 CO2 release in human carbonic anhydrase II crystals: reveal histidine 64 and solvent dynamics
5NXG 2018-01-17 1.2 Carbonic Anhydrase II Inhibitor RA1
4Q09 2015-01-28 1.2 Crystal structure of chimeric carbonic anhydrase XII with inhibitor
5T74 2017-09-06 1.2 Human carboanhydrase F131C_C206S double mutant in complex with 14
5NYA 2018-01-17 1.2 Carbonic Anhydrase II Inhibitor RA13
4FIK 2012-06-27 1.2 Human carbonic anhydrase II H64A complexed with thioxolone hydrolysis products
6QFW 2019-04-17 1.2 Human carbonic anhydrase II with bound IrCp* complex (cofactor 9) to generate an artificial transfer hydrogenase (ATHase)
3RJ7 2012-02-29 1.2 Human carbonic anhydrase II complexed with its inhibitor rhenium(I)triscarbonyl-cyclopentadienyl-carboxy-4-aminomethylbenzene-sulfonamide
6B4D 2018-02-07 1.2 Crystal structure of human carbonic anhydrase II in complex with a heteroaryl-pyrazole carboxylic acid derivative.
5NXO 2018-01-17 1.2 Carbonic Anhydrase II Inhibitor RA6
5JES 2017-01-11 1.21 Human carbonic anhydrase II (V121T) complexed with benzo[d]thiazole-2-sulfonamide
5U0F 2017-08-30 1.21 Identification of a New Zinc Binding Chemotype by Fragment Screening
5EH5 2016-03-09 1.21 human carbonic anhydrase II in complex with ligand
5JG3 2017-01-11 1.21 Human carbonic anhydrase II (121T/N67Q) complexed with benzo[d]thiazole-2-sulfonamide
5TXY 2017-08-30 1.21 Identification of a New Zinc Binding Chemotype of by Fragment Screening on human carbonic anhydrase
5EHV 2016-03-09 1.21 human carbonic anhydrase II in complex with ligand
6D1M 2018-06-13 1.21 Design, synthesis, and X-ray of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects
3L14 2011-01-05 1.22 Human Carbonic Anhydrase II complexed with Althiazide
4CNX 2015-02-04 1.23 Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture
4YGN 2015-03-25 1.23 NaI--Interactions between Hofmeister Anions and the Binding Pocket of a Protein
2FOQ 2006-02-28 1.25 Human Carbonic Anhydrase II complexed with two-prong inhibitors
3S71 2011-10-19 1.25 The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
5YUJ 2018-08-01 1.25 CO2 release in human carbonic anhydrase II crystals: reveal histidine 64 and solvent dynamics
5NXP 2018-01-17 1.25 Carbonic Anhydrase II Inhibitor RA7
5NXM 2018-05-30 1.25 Carbonic Anhydrase II Inhibitor RA1
5WEX 2017-10-11 1.26 Discovery of new selenoureido analogs of 4-(4-fluorophenylureido) benzenesulfonamides as carbonic anhydrase inhibitors
3GZ0 2009-07-21 1.26 Apo-human carbonic anhydrase II revisited: Implications of the loss of a metal in protein structure, stability and solvent network
5U0E 2017-08-30 1.27 Identification of a New Zinc Binding Chemotype by Fragment Screening
5SZ5 2016-12-28 1.27 Carbonic anhydrase IX-mimic in complex with 4-(2-methylphenyl)-benzenesulfonamide
4Z1J 2015-08-26 1.27 Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)
6C7W 2018-05-23 1.28 Carbonic anhydrase 2 in complex with [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDRO-2-FURANYL]METHYL SULFAMATE inhibitor
5G0C 2016-05-25 1.28 An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C
5NEA 2017-12-06 1.3 Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(2-methyl-1,3-oxazol-5-yl)benzene-1-sulfonammide
6ODZ 2019-06-12 1.3 Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects
5T71 2017-09-06 1.3 Human carboanhydrase F131C_C206S double mutant in complex with SA-2
5N1R 2017-12-27 1.3 Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4'-Pyrazol-1-ylmethyl-biphenyl-4-sulfonamide
5DSK 2016-05-04 1.3 Structure of CO2 released holo-form of human carbonic anhydrase II with 3 min warming
6GXE 2019-05-08 1.3 Carbonic Anhydrase CAIX mimic in complex with inhibitor JS14
6OE0 2019-06-12 1.3 Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects
4QIY 2015-04-15 1.3 Crystal structure of human carbonic anhydrase isozyme II with inhibitor
5DSR 2016-05-04 1.3 Structure of CO2 released apo-form of human carbonic anhydrase II with 10 min warming
3PYK 2011-07-13 1.3 Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor
5T72 2017-09-06 1.3 Human carboanhydrase F131C_C206S double mutant in complex with 2
5N1S 2017-12-27 1.3 Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(1H-Indol-2-yl)-benzenesulfonamide
3S8X 2012-04-11 1.3 Crystal structure of human carbonic anhydrase isozyme II with 4-{[(4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide
5DSM 2016-05-04 1.3 Structure of CO2 released holo-form of human carbonic anhydrase II with 25 min warming
3S9T 2012-04-18 1.3 Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-{[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide
5E28 2016-01-20 1.3 Crystal structure of human carbonic anhydrase II in complex with the 4-(4-aminophenyl)benzenesulfonamide inhibitor
4RH2 2015-11-11 1.3 Crystal structure of human carbonic anhydrase II in complex with 2-(6-hydroxy-3-Oxo-3H-xanthen-9-yl)-5-{3-1-(4-sulfamoyl-phenyl)-1h-[1,2,3]triazol-4-ylmethyl-thioureido}-benzoic acid
6H3Q 2019-07-17 1.31 Crystal structure of human carbonic anhydrase II in complex with the 4-(5-(chloromethyl)-1,3-selenazol-2-yl)benzenesulfonamide
3ZP9 2013-10-30 1.31 Human Carbonic Anhydrase II as a Scaffold for an Artificial Transfer Hydrogenase
6QFX 2019-04-17 1.32 Human carbonic anhydrase II with bound IrCp* complex (cofactor 10) to generate an artificial transfer hydrogenase (ATHase)
5ZXW 2018-06-13 1.32 Crystal structure of human carbonic anhydrase II crystallized by ammonium sulfate
5THN 2017-04-26 1.33 Crystal Structure of 2-Hydroxycyclohepta-2,4,6-triene-1-thione bound to human carbonic anhydrase 2
5EKM 2016-01-06 1.33 Human Carbonic Anhydrase II complexed with a two-faced guest
4HEZ 2013-10-23 1.34 Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
5JDV 2017-01-11 1.34 Human carbonic anhydrase II (F131W) complexed with benzo[d]thiazole-2-sulfonamide
5EKH 2016-01-06 1.34 Human Carbonic Anhydrase II complexed with a two-faced guest
4Z1K 2015-08-26 1.35 Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)
6GXB 2019-05-08 1.35 Carbonic Anhydrase CAIX mimic in complex with inhibitor JS13
4QK3 2015-03-04 1.35 Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - [delta]230-240
3M1K 2010-11-17 1.35 Carbonic Anhydrase in complex with fragment
5G03 2016-05-25 1.35 An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C
3MYQ 2011-02-02 1.35 Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-[(1H-imidazo[4,5-c]quinolin-2-ylsulfanyl)acetyl]benzenesulfonamide
4BF1 2014-01-22 1.35 Three dimensional structure of human carbonic anhydrase II in complex with 5-(1-naphthalen-1-yl-1,2,3-triazol-4-yl)thiophene-2-sulfonamide
5ULN 2017-10-11 1.35 Synthesis of novel seleno ureido containing compounds as SLC-0111 analogs. Investigations on carbonic anhydrases activity, glutathione peroxidase and X-ray crystallography
4KUV 2014-06-25 1.35 Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(4-chlorophenylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor
3KNE 2011-05-18 1.35 Carbonic Anhydrase II H64C mutant in complex with an in situ formed triazole
4MDG 2014-01-01 1.35 Closo Carborane Carbonic Anhydrase Inhibitor
5JQT 2016-10-19 1.36 Crystal structure of human carbonic anhydrase II in complex with Benzoxaborole at pH 7.4
5AML 2015-04-08 1.36 Three dimensional structure of human carbonic anhydrase II in complex with 2-(But-2-yn-1-ylsulfamoyl)-4-sulfamoylbenzoic acid
6PGX 2019-08-21 1.36 Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity
3RYZ 2011-08-10 1.37 Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
5EH8 2016-03-09 1.38 human carbonic anhydrase II in complex with ligand
3M14 2011-05-25 1.38 Carbonic Anhydrase II in complex with novel sulfonamide inhibitor
3M1W 2011-05-25 1.38 Carbonic Anhyrdase II mutant W5CH64C with closed disulfide bond in complex with sulfate
3KIG 2010-11-17 1.39 Mutant carbonic anhydrase II in complex with an azide and an alkyne
3RYJ 2011-08-10 1.39 Carbonic Anhydrase complexed with 4-sulfamoyl-N-(2,2,2-trifluoroethyl)benzamide
5VGY 2017-08-30 1.39 Identification of a New Zinc Binding Chemotype by Fragment Screening
5EHW 2016-03-09 1.39 human carbonic anhydrase II in complex with ligand
5WLU 2018-08-01 1.39 Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide
5DSP 2016-05-04 1.4 Structure of CO2 released apo-form of human carbonic anhydrase II with 40 sec warming
5WLV 2018-08-01 1.4 Carbonic Anhydrase II in complex with aryloxy-2-hydroxypropylammine sulfonamide
5BRW 2015-06-17 1.4 Catalytic Improvement of an Artificial Metalloenzyme by Computational Design
3M96 2011-02-02 1.4 Crystal structure of human carbonic anhydrase isozyme II with 5-{[(5-bromo-1H-benzimidazol-2-yl)sulfanyl]acetyl}-2-chlorobenzenesulfonamide
5JQ0 2016-10-19 1.4 Crystal structure of human carbonic anhydrase II in complex with Benzoxaborole at pH=8.7
5N25 2017-12-27 1.4 Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-Pyridin-3-yl-benzenesulfonamide
2WEO 2009-11-10 1.4 Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors
3M04 2011-05-25 1.4 Carbonic Anhydrase II in complex with novel sulfonamide inhibitor
4QSB 2015-01-21 1.4 Crystal structure of human carbonic anhydrase isozyme II with 3-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}benzenesulfonamide
5NY3 2018-01-17 1.4 Carbonic Anhydrase II Inhibitor RA11
6D1L 2018-06-13 1.4 Design, synthesis, and X-ray of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects
5DSO 2016-05-04 1.4 Structure of CO2 bound apo-form of human carbonic anhydrase II with 0 sec (no) warming
3MWO 2010-06-09 1.4 Human carbonic anhydrase II in a doubled monoclinic cell: a re-determination
5G01 2016-05-25 1.4 An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C
2QO8 2008-01-22 1.4 Crystal structure of the complex of hcaii with an indane-sulfonamide inhibitor
5E2K 2016-01-20 1.4 Crystal structure of human carbonic anhydrase II in complex with the 4-(3-aminophenyl)benzenesulfonamide inhibitor
3SBI 2012-04-11 1.4 Crystal structure of human carbonic anhydrase isozyme II with 4-[(2-pyrimidinylsulfanyl)acetyl]benzenesulfonamide
3S74 2011-10-19 1.4 The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
3M5S 2011-05-25 1.4 Carbonic Anhydrase II mutant H64C in complex with carbonate
3IBU 2009-09-22 1.41 The crystal structure of the human carbonic anhydrase II in complex with an aliphatic sulfamate inhibitor
5TI0 2017-04-26 1.42 Crystal Structure of 2-Hydroxycyclohepta-2,4,6-triene-1-thione bound to human carbonic anhydrase 2 L198G
5EH7 2016-03-09 1.42 human carbonic anhydrase II in complex with ligand
5LVS 2017-03-08 1.42 Self-assembled protein-aromatic foldamer complexes with 2:3 and 2:2:1 stoichiometries
6CEH 2018-05-23 1.43 Design, Synthesis, X-ray and Biological Activities of Selenides Bearing the Benzenesulfonamide Moiety as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology
3HLJ 2010-03-02 1.44 Crystal structure of human carbonic anhydrase isozyme II with 3-methylthiobenzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonamide
6HX5 2018-12-26 1.44 Selenols: a new class of Carbonic Anhydrase inhibitors
4Q8Y 2015-03-11 1.45 Crystal structure of 2-hydroxyisoquinoline-1(2H)-thione bound to human carbonic anhydrase II
5WG7 2018-02-07 1.45 Human Carbonic Anhydrase II complexed with AceK
5YUK 2018-08-01 1.45 CO2 release in human carbonic anhydrase II crystals: reveal histidine 64 and solvent dynamics
5TY8 2017-08-30 1.45 Identification of a New Zinc Binding Chemotype by Fragment Screening
2QP6 2008-06-03 1.45 The crystal structure of the complex of hcaII with a bioreductive antitumor derivative
4YWP 2015-10-14 1.45 Sucrose Binding Site in genetically engineered Carbonic anhydrase IX
3OKV 2011-07-06 1.45 Human Carbonic Anhydrase II A65S, N67Q (CA IX mimic) bound with 2-Ethylestrone 3-O-sulfamate
6H6S 2019-01-09 1.45 Sad phasing on nickel-substituted human carbonic anhydrase II
6QFV 2019-04-17 1.45 Human carbonic anhydrase II with bound IrCp* complex (cofactor 8) to generate an artificial transfer hydrogenase (ATHase)
4E49 2012-06-27 1.45 Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
4KAP 2013-07-10 1.45 The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand
4E4A 2012-06-27 1.45 Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
4Z0Q 2015-08-26 1.45 Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)
3OIM 2011-07-06 1.45 Human Carbonic anhydrase II bound by 2-Ethylestradiol 3-O-sulfamate
5DSL 2016-05-04 1.45 Structure of CO2 released holo-form of human carbonic anhydrase II with 10 min warming
4YVY 2016-03-30 1.45 Crystal structure of human carbonic anhydrase II in complex with hydroxylamine-O-sulfonamide, a molecule incorporating two zinc-binding groups.
4Q7W 2015-03-11 1.45 Crystal structure of 1-hydroxy-6-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II
2WEJ 2009-11-10 1.45 Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors
6OE1 2019-06-12 1.45 Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects
3OKU 2011-07-06 1.45 Human Carbonic Anhydrase II in complex with 2-Ethylestrone-3-O-sulfamate
4HEY 2013-10-23 1.45 Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
4CQ0 2014-04-16 1.45 Cyclic secondary sulfonamides: unusually good inhibitors of cancer- related carbonic anhydrase enzymes
6H29 2018-09-05 1.46 HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BENZYL CARBAMATE
2GD8 2007-02-06 1.46 Crystal structure analysis of the human carbonic anhydrase II in complex with a 2-substituted estradiol bis-sulfamate
2AW1 2006-07-04 1.46 Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor Celecoxib
4Z1N 2015-08-26 1.47 Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)
3QYK 2012-03-07 1.47 Human Carbonic Anhydrase II complexed with triple ring benzene sulfonamide inhibitor
3V2M 2012-12-26 1.47 Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II
3OYQ 2011-08-10 1.47 Structure of Human Carbonic Anhydrase II complexed with 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE
4QEF 2014-10-08 1.47 Human Carbonic Anhydrase II V207I - cyanate inhibitor complex
5TH4 2017-04-26 1.47 Crystal Structure of 1-hydroxypyridine-2(1H)-thione bound to human carbonic anhydrase 2 L198G
3PO6 2011-04-06 1.47 Crystal structure of human carbonic anhydrase II with 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide
3DD0 2009-03-03 1.48 Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
4DZ7 2013-03-27 1.49 hCA II in complex with novel sulfonamide inhibitors Set D
3P5A 2011-10-19 1.49 Human Carbonic Anhydrase complexed with Sodium morpholinocarbodithioate
2WD2 2010-03-31 1.49 A chimeric microtubule disruptor with efficacy on a taxane resistant cell line
5WLR 2018-08-01 1.49 Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide
4DZ9 2013-03-27 1.49 hCA II in complex with novel sulfonamide inhibitors Set D
3P58 2011-10-19 1.49 Human Carbonic Anhydrase in complex with Benzyl (Methyl) Carbamodithoic Acid
3OIL 2011-07-06 1.5 Human Carbonic anhydrase II mutant A65S, N67Q (CA IX mimic) bound by 2-Ethylestradiol 3-O-sulfamate
5AMD 2015-04-08 1.5 Three dimensional structure of human carbonic anhydrase II in complex with 2-((2-Phenylethyl)sulfamoyl)-4-sulfamoylbenzoic acid
3KON 2010-08-25 1.5 Crystal structure of cobalt (II) human carbonic anhydrase II at pH 11.0
4E3H 2012-06-27 1.5 Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
5EHE 2016-11-09 1.5 Crystal structure of human carbonic anhydrase isozyme II with 3-(benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
3OIK 2011-07-06 1.5 Human Carbonic anhydrase II mutant A65S, N67Q (CA IX mimic) bound by 2-Ethylestradiol 3,17-O,O-bis-sulfamate
5TFX 2017-08-09 1.5 New method for synthesis of benzoxazole amide inhibitors of carbonic anhydrase
5THI 2017-04-26 1.5 Crystal Structure of 2-hydroxycyclohepta-2,4,6-trien-1-one bound to human carbonic anhydrase 2 L198G
6C7X 2018-05-23 1.5 Carbonic anhydrase 2 in complex with 2-chloro-5'-O-sulfamoyladenosine
4GL1 2013-09-04 1.5 Structure of H64A/N62L/N67L Human Carbonic Anhydrase II triple mutant
3P3H 2011-09-21 1.5 Human carbonic anhydrase II in complex with p-(5-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide
3KOK 2010-08-25 1.5 Crystal structure of cobalt (II) human carbonic anhydrase II at pH 8.5
3MMF 2011-04-20 1.5 Crystal structure of human carbonic anhydrase II in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor
3RLD 2012-02-08 1.5 Crystal structure of the Y7I mutant of human carbonic anhydrase II
5E2S 2016-01-20 1.5 Crystal structure of human carbonic anhydrase II in complex with the 4-(2-iso-propylphenyl)benzenesulfonamide inhibitor
3N3J 2011-03-09 1.5 Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor
3P5L 2011-10-19 1.5 Human Carbonic Anhydrase complexed with sodium 4-cyano-4-phenylpiperidine-1-carbodithioate
5N24 2017-12-27 1.5 Crystal structure of human carbonic anhydrase II in complex with the inhibitor b4'-Cyano-biphenyl-4-sulfonic acid amide
4R5B 2014-10-15 1.5 Human Carbonic Anhydrase II in Complex with a Carbohydrate-Based Sulfamate
3DCW 2009-03-03 1.5 Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
4ZWY 2015-08-05 1.5 Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor
2AX2 2006-01-03 1.5 Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II
3S75 2011-10-19 1.5 The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
4Q99 2015-03-11 1.5 Crystal structure of 2-mercapto-4-methylphenol bound to human carbonic anhydrase II
4JSA 2013-06-19 1.5 Benzenesulfonamide complexed with hCAII H94D
1FR7 2001-01-17 1.5 X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT
4QSA 2015-01-21 1.5 Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-4-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}benzenesulfonamide
3N0N 2011-03-16 1.5 Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor
4ZX1 2015-10-28 1.5 Engineered Carbonic Anhydrase IX mimic in complex with a glucosyl sulfamate inhibitor
5TYA 2017-08-30 1.5 Identification of a New Zinc Binding Chemotype by Fragment Screening
3M98 2011-03-02 1.5 Crystal structure of human carbonic anhydrase isozyme II with 5-(1H-benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide
4E3F 2012-06-27 1.5 Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
4Q8Z 2015-03-11 1.5 Crystal structure of 1-hydroxy-4-methylpyridin-2(1H)-one bound to human carbonic anhydrase II
5THJ 2017-04-26 1.5 Crystal Structure of 2-hydroxycyclohepta-2,4,6-trien-1-one bound to human carbonic anhydrase 2
4BCW 2013-02-06 1.5 Carbonic anhydrase IX mimic in complex with (E)-2-(5-bromo-2- hydroxyphenyl)ethenesulfonic acid
5DSQ 2016-05-04 1.5 Structure of CO2 released apo-form of human carbonic anhydrase II with 3 min warming
5T75 2017-09-06 1.5 Human carbonic anhydrase II G132C_C206S double mutant in complex with SA-2
4JSS 2013-06-19 1.5 Human carbonic anhydrase II H94D bound to a bidentate inhibitor
3TVN 2012-08-08 1.5 Human Carbonic Anhydrase II Proton Transfer Mutant
3MHM 2010-10-20 1.5 Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-benzylamino-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide
4YGK 2015-03-25 1.5 NaSCN--Interactions between Hofmeister Anions and the Binding Pocket of a Protein
4QY3 2014-12-03 1.5 THE CRYSTAL STRUCTURE OF THE COMPLEX of HCAII WITH AN ORTHO-SUBSTITUTED BENZOIC ACID
3MZC 2011-03-09 1.5 Human carbonic ahydrase II in complex with a benzenesulfonamide inhibitor
3V5G 2012-07-25 1.5 Crystal structure of human carbonic anhydrase II in complex with the 4-sulfamido-benzenesulfonamide inhibitor
6MBY 2019-03-13 1.5 Carbonic Anhydrase II in complex with Ferulic Acid
3RG4 2012-02-22 1.5 Crystal structure of the W5F mutant of human carbonic anhydrase II
3MNA 2011-04-20 1.5 The crystal structure of human carbonic anhydrase Ii in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor
1OQ5 2004-03-23 1.5 CARBONIC ANHYDRASE II IN COMPLEX WITH NANOMOLAR INHIBITOR
3RZ1 2011-08-10 1.51 Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
4YGL 2015-03-25 1.51 NaClO4--Interactions between Hofmeister Anions and the Binding Pocket of a Protein
4QK2 2015-03-04 1.52 Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - E234P
5JN1 2017-05-03 1.52 Carbonic Anhydrase IX-mimic IN Complex WITH U-CH3
4MDL 2014-01-01 1.52 Meta Carborane Carbonic Anhydrase Inhibitor
5JN7 2017-05-03 1.52 Carbonic Anhydrase II In Complex WITH U-CH3
5WGP 2018-02-07 1.53 Human Carbonic Anhydrase IX-mimic complexed with AceK
4RN4 2015-01-28 1.53 Human Carbonic anhydrases II in complex with a acetazolamide derivative comprising one hydrophobic and one hydrophilic tail moiety
5TY9 2017-08-30 1.53 Identification of a New Zinc Binding Chemotype by Fragment Screening
2CBA 1993-10-31 1.54 STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES
4N16 2014-06-18 1.54 Structure of cholate bound to human carbonic anhydrase II
3OYS 2011-08-10 1.54 Human Carbonic Anhydrase II complexed with 2-{[4-AMINO-3-(3-HYDROXYPROP-1-YN-1-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL]METHYL}-5-METHYL-3-(2-METHYLPHENYL)QUINAZOLIN-4(3H)-ONE
4Q90 2015-03-11 1.54 Crystal structure of 4-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II
5U0G 2017-08-30 1.54 Identification of a New Zinc Binding Chemotype by Fragment Screening
5EZT 2016-07-20 1.54 Peracetylated Bovine Carbonic Anhydrase II
4MDM 2014-01-01 1.55 Nido-Carborane Carbonic Anhydrase Inhibitor
3U3A 2012-10-10 1.55 structure of Human Carbonic Anhydrase II V143I
5SZ1 2016-12-21 1.55 Carbonic anhydrase II in complex with 4-(2-methylphenyl)-benzenesulfonamide
4Q83 2015-03-11 1.55 Crystal structure of 1-hydroxy-3-(trifluoromethyl)pyridine-2(1H)-thione bound to human carbonic anhydrase II
4E3G 2012-06-27 1.55 Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
4Q9Y 2015-03-11 1.55 Crystal structure of 3-methylthiophenol bound to human carbonic anhydrase II
4KV0 2014-06-25 1.55 Crystal structure of human carbonic anhydrase II in complex with the 5-(3-tosylureido)pyridine-2-sulfonamide inhibitor
2HNC 2006-12-19 1.55 Crystal structure of the human carbonic anhydrase II in complex with the 5-amino-1,3,4-thiadiazole-2-sulfonamide inhibitor.
2HL4 2007-05-22 1.55 Crystal structure analysis of human carbonic anhydrase II in complex with a benzenesulfonamide derivative
6H34 2018-12-19 1.55 The crystal structure of human carbonic anhydrase II in complex with 4-[(4-fluorophenyl)methyl]-1-piperazinyl]benzenesulfonamide.
4Q87 2015-03-11 1.55 Crystal structure of 1-hydroxy-4-(trifluoromethyl)pyridine-2(1H)-thione bound to human carbonic anhydrase II
5G0B 2016-05-25 1.55 An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C
4Q81 2015-03-11 1.55 Crystal structure of 1-hydroxy-4,6-dimethylpyridine-2(1H)-thione bound to human carbonic anhydrase II
4Q8X 2015-03-11 1.55 Crystal structure of 1-hydroxy-5-(trifluoromethyl)pyridine-2(1H)-thione bound to human carbonic anhydrase II
3IBL 2009-09-22 1.55 The crystal structure of the human carbonic anhydrase II in complex with an aliphatic bis-sulfamate inhibitor
4JS6 2013-06-19 1.55 Crystal structure of inhibitor-free hCAII H94D
1ZFQ 2006-05-23 1.55 carbonic anhydrase II in complex with ethoxzolamidphenole as sulfonamide inhibitor
4KUW 2014-06-25 1.55 Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(4-fluorophenylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor
5CLU 2015-11-11 1.55 THE CRYSTAL STRUCTURE OF THE COMPLEX of HCAII WITH A SACCHARINE DERIVATIVE
6CJV 2018-08-08 1.55 Carbonic anhydrase IX-mimic in complex with sucralose
5AMG 2015-04-08 1.55 Three dimensional structure of human carbonic anhydrase II in complex with 2-(Pentylsulfamoyl)-4-sulfamoylbenzoic acid
3V3G 2012-06-20 1.56 Kinetic and structural studies of thermostabilized mutants of HCA II.
2VVA 2009-07-14 1.56 Human carbonic anhydrase in complex with CO2
6GOT 2018-10-03 1.56 Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(phenethylthio)benzenesulfonamide
1ZFK 2006-05-23 1.56 carbonic anhydrase II in complex with N-4-sulfonamidphenyl-N'-4-methylbenzosulfonylurease as sulfonamide inhibitor
5WLT 2018-08-01 1.57 Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide
5A6H 2016-05-25 1.57 Synthesis, carbonic anhydrase inhibition and protein X-ray structure of the unusual natural product primary sulfonamide Psammaplin C
6H33 2018-12-19 1.58 The crystal structure of human carbonic anhydrase II in complex with 4-(4-phenyl)-4-hydroxy-1-piperidine-1-carbonyl)benzenesulfonamide.
5FNL 2016-09-28 1.59 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
5FNM 2016-03-02 1.59 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
5FNK 2016-03-02 1.59 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
5U0D 2017-08-30 1.59 Identification of a New Zinc Binding Chemotype by Fragment Screening
4ILX 2013-02-13 1.6 Structure of human carbonic anhydrase II in complex with an adamantyl sulfonamide inhibitor
5BRU 2015-06-24 1.6 Catalytic Improvement of an Artificial Metalloenzyme by Computational Design
2OSM 2008-02-12 1.6 Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study
3R16 2011-05-25 1.6 Human CAII bound to N-(4-sulfamoylphenyl)-2-(thiophen-2-yl) acetamide
3DVC 2008-11-11 1.6 X-ray crystal structure of mutant N62T of human Carbonic Anhydrase II
4K13 2014-04-09 1.6 Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with dorzolamide
3DAZ 2009-03-03 1.6 Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
1G0E 2000-10-18 1.6 SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH 4-METHYLIMIDAZOLE
3TVO 2012-08-08 1.6 Human Carbonic Anhydrase II Proton Transfer Double Mutant
3P3J 2011-09-21 1.6 Human carbonic anhydrase II in complex with p-(5-ruthenocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide
3DCC 2009-03-03 1.6 Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
3DVD 2008-11-11 1.6 X-ray crystal structure of mutant N62D of human Carbonic Anhydrase II
3RYX 2011-08-10 1.6 Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
5W8B 2018-05-30 1.6 Carbonic anhydrase II in complex with activating histamine pyridinium derivative
4IWZ 2013-12-11 1.6 structure of hCAII in complex with an acetazolamide derivative
4Q7V 2015-03-11 1.6 Crystal structure of 1-hydroxy-5-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II
5BRV 2015-06-24 1.6 Catalytic Improvement of an Artificial Metalloenzyme by Computational Design
1G0F 2000-10-18 1.6 SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMAN CARBONIC ANHYDRASE II
4E3D 2012-06-27 1.6 Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
4ZX0 2015-10-28 1.6 Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor
2FMG 2006-05-23 1.6 Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine and crystallographic analysis of their adducts with isozyme II: sterospecific recognition within the active site of an enzyme and its consequences for the drug design, structure with L-phenylalanine
4IDR 2012-12-26 1.6 Human Carbonic Anhydrase II Proton Transfer Double Mutant
2OSF 2008-05-27 1.6 Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study
2QOA 2008-01-22 1.6 Crystal structure of the complex of hcaii with an indane-sulfonamide inhibitor
5JN3 2017-05-03 1.6 Carbonic Anhydrase IX-mimic IN Complex WITH U-F
3M40 2010-10-20 1.6 Crystal structure of human carbonic anhydrase isozyme II with 4-[N-(6-chloro-5-nitropyrimidin-4-yl)amino]benzenesulfonamide
3DC9 2009-03-03 1.6 Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
4QK1 2015-03-04 1.6 Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - K170P
1FR4 2001-01-17 1.6 X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
1CIL 1994-01-31 1.6 THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS
4HT0 2013-04-10 1.6 Crystal structure of human carbonic anhydrase isozyme II with the inhibitor.
2EU3 2006-07-11 1.6 Human Carbonic anhydrase II in complex with novel inhibitors
3S72 2011-10-19 1.6 The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
3N4B 2011-03-09 1.6 Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor
5FNI 2016-03-02 1.6 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
3S76 2011-10-19 1.6 The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
2POV 2007-07-24 1.6 The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-chloro-benzene-1,3-disulfonamide
2FMZ 2006-05-23 1.6 Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine, structure with D-Phenylalanine.
5TY1 2017-10-04 1.6 Identification of a New Zinc Binding Chemotype by Fragment Screening
6E8X 2019-03-27 1.6 CA IX mimic Complexed with Steroidal Sulfamate Compound STX 140
2POU 2007-07-24 1.6 The crystal structure of the human carbonic anhydrase II in complex with 4,5-dichloro-benzene-1,3-disulfonamide
5SZ4 2016-12-21 1.6 Carbonic anhydrase IX-mimic in complex with 4-(phenyl)-benzenesulfonamide
3U47 2012-10-10 1.6 Human Carbonic Anhydrase II V143L
5E2R 2015-11-04 1.6 The crystal structure of the human carbonic anhydrase II in complex with a 1,1'-biphenyl-4-sulfonamide inhibitor
4ZWI 2015-08-26 1.6 Surface Lysine Acetylated Human Carbonic Anhydrase II in Complex with a Sulfamate-Based Inhibitor
3OY0 2011-08-10 1.6 Human Carbonic Anhydrase II complexed with 1-(4-(4-(2-(ISOPROPYLSULFONYL)PHENYLAMINO)-1H-PYRROLO[2,3-B]PYRIDIN-6-YLAMINO)-3-METHOXYPHENYL)PIPERIDIN-4-OL
4LHI 2014-07-02 1.6 Crystal structure of human carbonic anhydrase isozyme II with 5-(phenylsulfonyl)thiophene-2-sulfonamide
4ZWZ 2015-08-05 1.62 Engineered Carbonic Anhydrase IX mimic in complex with a glucosyl sulfamate inhibitor
6B5A 2018-09-05 1.62 Carbonic anhydrase IX-mimic in complex with nitrogenous base-bearing benezenesulfonamide
4CNV 2015-02-04 1.62 Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture
5SZ2 2016-12-21 1.63 Carbonic anhydrase II in complex with 4-(3-formylphenyl)-benzenesulfonamide
3V3J 2012-06-20 1.63 Kinetic and structural studies of thermostabilized mutants of HCA II.
6EEA 2018-11-28 1.63 Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
4L5V 2014-04-30 1.63 The structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II
6EEH 2018-11-28 1.63 Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
1TH9 2005-01-25 1.63 Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
5SZ0 2016-12-21 1.63 Carbonic anhydrase II in complex with 4-(phenyl)-benzenesulfonamide
4RIV 2015-02-04 1.63 A Carbonic Anhydrase IX Mimic in Complex with Saccharin
4RUZ 2015-04-22 1.63 Crystal structure of human Carbonic Anhydrase II in complex with 4-ethoxybenzenesulfonamide
4RFD 2015-04-15 1.63 Human carbonic anhydrase II in complex with 4-(4-sulfamoyl-phenoxy)-butylammonium
4N0X 2014-01-29 1.63 Room temperature crystal structure of human carbonic anhydrase II in complex with thiophene-2-sulfonamide
4R5A 2014-10-15 1.64 A Carbonic Anhydrase IX Mimic in Complex with a Carbohydrate-Based Sulfamate
2X7S 2010-03-31 1.64 Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.
4RFC 2015-04-15 1.64 Human carbonic anhydrase II in complex with tert-butyl 4-(4-sulfamoylphenoxy)butylcarbamate
3KOI 2010-08-25 1.64 Crystal structure of cobalt (III) human carbonic anhydrase II at pH 6.0
6B59 2018-09-05 1.64 Carbonic anhydrase II in complex with nitrogenous base-bearing benezenesulfonamide
4KUY 2014-06-25 1.65 Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(o-tolylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor
2NWY 2007-04-24 1.65 Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II
3D9Z 2009-03-03 1.65 Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
6EQU 2017-12-13 1.65 X-Ray crystal structure of the human carbonic anhydrase II adduct with a membrane-impermeant inhibitor
4Q7P 2015-03-11 1.65 Crystal Structure of 1-hydroxy-3-methylpyridine-2(1H)-thione bound to hCAII
3M2N 2011-02-16 1.65 Crystal structure of human carbonic anhydrase isozyme II with 4-{2-[N-(6-chloro-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide
4R59 2014-10-15 1.65 A Carbonic Anhydrase IX Mimic in Complex with a Carbohydrate-Based Sulfamate
3T5Z 2012-06-20 1.65 Crystal structure of the human carbonic anhydrase II in complex with N-methoxy-benzenesulfonamide
3N2P 2011-03-09 1.65 Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor
3IGP 2010-03-09 1.65 Structure of inhibitor binding to Carbonic Anhydrase II
3SBH 2012-04-11 1.65 Crystal structure of human carbonic anhydrase isozyme II with 4-{[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide
4RIU 2015-02-04 1.65 A Carbonic Anhydrase IX Mimic in Complex with a Saccharin-Based Inhibitor
1ZGE 2006-05-23 1.65 carbonic anhydrase II in complex with p-Sulfonamido-o,o'-dichloroaniline as sulfonamide inhibitor
3RZ5 2011-08-10 1.65 Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
4MLX 2014-07-02 1.65 Structure of a bidentate 3-hydroxy-4H-pyran-4-thione ligand bound to hCAII
3MNH 2010-07-14 1.65 Human Carbonic Anhydrase II Mutant K170A
5FNH 2016-03-02 1.66 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
2VVB 2009-07-14 1.66 Human carbonic anhydrase II in complex with bicarbonate
4M2W 2013-11-06 1.66 Genetically engineered Carbonic Anhydrase IX in complex with Dorzolamide
1Z9Y 2006-05-23 1.66 carbonic anhydrase II in complex with furosemide as sulfonamide inhibitor
5FLO 2016-03-02 1.66 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
5FLS 2016-03-02 1.67 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
2CBB 1993-10-31 1.67 STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES
5FNJ 2016-03-02 1.67 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
2CBD 1993-10-31 1.67 STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES
5FLT 2016-03-02 1.67 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
3M3X 2010-10-20 1.68 Crystal structure of human carbonic anhydrase isozyme II with 4-{2-[N-(6-methoxy-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide
5FLR 2016-03-02 1.68 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
3M1Q 2011-05-25 1.69 Carbonic Anhydrase II mutant W5C-H64C with opened disulfide bond
5SZ3 2016-12-21 1.69 Carbonic anhydrase II in complex with 4-(3-quinolinyl)-benzenesulfonamide
2Q1B 2007-09-04 1.7 Carbonic Anhydrase II in Complex with Saccharin
3DBU 2009-03-03 1.7 Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
4E5Q 2013-03-27 1.7 Human Carbonic Anhydrase II in complex with cyanate
5FLQ 2016-03-02 1.7 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
5LMD 2016-10-19 1.7 The crystal structure of hCA II in complex with a benzoxaborole inhibitor
5DOG 2016-09-28 1.7 Crystal structure of human carbonic anhydrase isozyme II with 2-(Benzylamino)-3,5,6-trifluoro-4-[(2-phenylethyl)thio]benzene- sulfonamide
6MBV 2019-03-13 1.7 Carbonic Anhydrase II in complex with Nicotinic Acid
1MUA 1993-10-31 1.7 STRUCTURE AND ENERGETICS OF A NON-PROLINE CIS-PEPTIDYL LINKAGE IN AN ENGINEERED PROTEIN
3MHI 2010-10-20 1.7 Crystal structure of human carbonic anhydrase isozyme II with 4-{[(5-nitro-6-oxo-1,6-dihydro-4-pyrimidinyl)amino]methyl}benzenesulfonamide
5N0D 2017-05-10 1.7 Crystal structure of human carbonic anhydrase II in complex with (R)-4-(6,7-dihydroxy-1-phenyl-3,4-tetrahydroisoquinoline-1H-2-carbonyl)benzenesulfonamide.
3HKQ 2009-10-13 1.7 Human carbonic anhydrase II in complex with 1-S-D-Galactopyranosylsulfonamide
3CYU 2008-05-27 1.7 Human Carbonic Anhydrase II complexed with Cryptophane biosensor and xenon
5NEE 2017-12-06 1.7 Crystal structure of human carbonic anhydrase II in complex with the inhibitor 5-[2-(morpholine-4-carbonyl)1,3-oxazol-5-yl)]thiophene-2-sulfonammide
5L6K 2017-03-01 1.7 Crystal Structure of Human Carbonic Anhydrase II in Complex with a Quinoline Oligoamide Foldamer
4ZWX 2015-10-28 1.7 Engineered Carbonic Anhydrase IX mimic in complex with glucosyl sulfamate inhibitor
5J8Z 2016-06-29 1.7 Human carbonic anhydrase II in complex with ligand
3DVB 2008-11-11 1.7 X-ray crystal structure of mutant N62V human Carbonic Anhydrase II
3C7P 2009-01-13 1.7 Crystal structure of human carbonic anhydrase II in complex with STX237
1ZH9 2006-05-23 1.7 carbonic anhydrase II in complex with N-4-Methyl-1-piperazinyl-N'-(p-sulfonamide)phenylthiourea as sulfonamide inhibitor
2NWO 2007-04-24 1.7 Structural and kinetic effect of hydrophobic mutations in the active site of human carbonic anhydrase II
3MHC 2010-07-21 1.7 Crystal structure of human cabonic anhydrase II in adduct with an adamantyl analogue of acetazolamide in a novel hydrophobic binding pocket
3DC3 2009-03-03 1.7 Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
3DV7 2008-11-11 1.7 Role of Hydrophilic Residues in Proton Transfer During Catalysis by Human Carbonic Anhydrase II (N62A)
3U45 2012-10-10 1.7 Human Carbonic Anhydrase II V143A
4ITP 2014-01-01 1.7 Structure of human carbonic anhydrase II bound to a benzene sulfonamide
1YO1 2005-09-20 1.7 Proton Transfer from His200 in Human Carbonic Anhydrase II
4K1Q 2014-04-09 1.7 Structure of hCAIX mimic (hCAII with 5 mutations in active site)
3RZ8 2011-08-10 1.7 Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
3M2Z 2011-07-06 1.7 Fragment tethered to Carbonic Anhydrase II H64C mutant
4L5W 2014-04-30 1.7 Structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II
3D8W 2009-03-03 1.7 Use of a carbonic Anhydrase II, IX Active-site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
3V2J 2012-12-26 1.7 Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II
3M5E 2010-10-20 1.7 Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-chloro-5-formyl-2-methylthiopyrimidin-4-yl)amino]methyl}benzenesulfonamide
4HEW 2013-10-23 1.7 Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
3R17 2011-05-25 1.7 hCarbonic anhydrase II bound to N-(2-fluoro.4-sulfamoylphenyl)-2-(thiophen-2-yl) acetamide
2NXR 2007-04-24 1.7 Structural effects of hydrophobic mutations on the active site of human carbonic anhydrase II
1CAM 1993-10-31 1.7 STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
5FLP 2016-03-02 1.71 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
2F14 2006-10-24 1.71 Tne Crystal Structure of the Human Carbonic Anhydrase II in Complex with a Fluorescent Inhibitor
6EEO 2018-11-28 1.72 Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
4M2V 2013-11-06 1.72 Genetically engineered Carbonic Anhydrase IX in complex with Brinzolamide
3V3I 2012-06-20 1.73 Kinetic and structural studies of thermostabilized mutants of HCA II.
3T5U 2012-06-20 1.75 Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide
4PYY 2015-01-28 1.75 Crystal structure of human carbonic anhydrase isozyme II with inhibitor
3SAP 2012-04-11 1.75 Crystal structure of human carbonic anhydrase isozyme II with 4-{[(5-butyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide
2POW 2007-07-24 1.75 The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide
3MNI 2010-07-14 1.75 Human Carbonic Anhydrase II Mutant K170D
5FDC 2016-05-18 1.75 Crystal structure of Human Carbonic Anhydrase II in complex with the anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog.
1LG5 2002-07-24 1.75 Crystal Structure Analysis of the HCA II Mutant T199P in complex with beta-mercaptoethanol
4QJM 2015-04-15 1.75 Crystal structure of human carbonic anhydrase isozyme II with inhibitor
1ZGF 2006-05-23 1.75 carbonic anhydrase II in complex with trichloromethiazide as sulfonamide inhibitor
5N0E 2017-05-10 1.75 Crystal structure of human carbonic anhydrase II in complex with (S)-4-(6,7-dihydroxy-1-phenyl-3,4-tetrahydroisoquinoline-1H-2-carbonyl)benzenesulfonamide.
3S73 2011-12-21 1.75 The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
3MNK 2010-07-14 1.75 Human Carbonic Anhydrase II Mutant K170H
3MNJ 2010-07-14 1.75 Human Carbonic Anhydrase II Mutant K170E
3EFI 2008-09-30 1.75 Carbonic anhydrase activators: Kinetic and X-ray crystallographic study for the interaction of d- and l-tryptophan with the mammalian isoforms I-XIV
4HBA 2013-07-31 1.76 Structural and Catalytic Characterization of a Thermal and Acid Stable Variant of Human Carbonic Anhydrase II Containing an Engineered Disulfide Bond
1XQ0 2005-05-17 1.76 Structure of human carbonic anhydrase II with 4-[(3-bromo-4-O-sulfamoylbenzyl)(4-cyanophenyl)amino]-4H-[1,2,4]-triazole
6E92 2019-03-27 1.77 CA IX mimic Complexed with Steroidal Sulfamate Compound STX 2845
4K0T 2014-04-09 1.78 Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with chlorzolamide
5SZ7 2016-12-21 1.78 Carbonic anhydrase IX-mimic in complex with 4-(3-quinolinyl)-benzenesulfonamide
4ZAO 2015-10-14 1.8 Genetically engineered Carbonic anhydrase IX
2NXS 2007-04-24 1.8 Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II
5GMN 2017-05-24 1.8 Crystal structure of human carbonic anhydrase II in complex with polmacoxib
2NWZ 2007-04-24 1.8 Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II
3RZ7 2011-08-10 1.8 Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
3CAJ 2008-04-08 1.8 Crystal structure of the human carbonic anhydrase II in complex with ethoxzolamide
1CAI 1993-10-31 1.8 STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
2FNK 2006-11-28 1.8 Activation of Human Carbonic Anhydrase II by exogenous proton donors
4QTL 2015-04-15 1.8 Crystal structure of human carbonic anhydrase isozyme II with inhibitor
2FNN 2006-11-28 1.8 Activation of human carbonic anhydrase II by exogenous proton donors
1TG3 2005-01-25 1.8 Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
1I9Q 2001-03-28 1.8 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(3,4,5-TRIFLUOROPHENYL)METHYL]-BENZAMIDE
1YO2 2005-09-20 1.8 Proton Transfer from His200 in Human Carbonic Anhydrase II
3HKN 2009-10-13 1.8 Human carbonic anhydrase II in complex with (2,3,4,6-Tetra-O-acetyl-beta-D-galactopyranosyl) -(1-4)-1,2,3,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosylsulfonamide
4Q49 2015-02-25 1.8 Room temperature neutron crystal structure of apo human carbonic anhydrase at pH 7.5
1RZB 1993-10-31 1.8 X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES
6E91 2019-03-27 1.8 CA IX mimic Complexed with Steroidal Sulfamate Compound STX 2484
2HD6 2006-10-03 1.8 Crystal structure of the human carbonic anhydrase II in complex with a hypoxia-activatable sulfonamide.
3M1J 2011-01-19 1.8 The crystal structure of a NAMI A-Carbonic Anhydrase II adduct discloses the mode of action of this novel anticancer metallodrug
4Q7S 2015-03-11 1.8 Crystal Structure of 1-hydroxy-4-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II
5O07 2017-08-02 1.8 The crystal structure of the human carbonic anhydrase II in complex with a nitroimidazole sulfamate inhibitor
3RZ0 2011-08-10 1.8 Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
4PYX 2015-01-28 1.8 Crystal structure of human carbonic anhydrase isozyme II with inhibitor
1RAY 1993-10-31 1.8 THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE
1CNI 1995-07-10 1.8 X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
3DCS 2009-03-03 1.8 Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
5EOI 2016-11-23 1.8 Crystal structure of copper bound human Carbonic anhydrase II
1THK 2005-01-25 1.8 Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
3PJJ 2012-01-18 1.8 Synthetic Dimer of Human Carbonic Anhydrase II
2FNM 2006-11-28 1.8 Activation of human carbonic anhdyrase II by exogenous proton donors
3M67 2010-11-03 1.8 Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-[(6,7-dihydro-1H-[1,4]dioxino[2,3-f]benzimidazol-2-ylsulfanyl)acetyl]benzenesulfonamide
3NB5 2011-04-20 1.8 Human carbonic anhydrase II in complex with 2-(3-chloro-4-hydroxyphenyl)-N-(4-sulfamoylphenethyl)acetamide
1ZSC 1996-07-11 1.8 CARBONIC ANHYDRASE II MUTANT E117Q, HOLO FORM
6QFU 2019-04-17 1.8 Human carbonic anhydrase II with bound IrCp* complex (cofactor 7) to generate an artificial transfer hydrogenase (ATHase)
2NWP 2007-04-24 1.8 Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II
3MNU 2010-06-16 1.8 Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron containing aromatic sulfamide with mammalian isoforms I-XV
1YO0 2005-09-20 1.8 Proton Transfer from His200 in Human Carbonic Anhydrase II
1CNJ 1995-07-10 1.8 X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
3ML2 2011-04-20 1.8 Human carbonic anhydsase II in complex with an aryl sulfonamide inhibitor
3T83 2011-10-19 1.8 Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates
4XE1 2015-03-18 1.8 Human carbonic anhydrase II in complex with 6-SULFAMOYL-SACCHARIN
2WD3 2010-02-23 1.8 Highly Potent First Examples of Dual Aromatase-Steroid Sulfatase Inhibitors based on a Biphenyl Template
6BCC 2018-02-28 1.8 Joint X-ray/neutron structure of human carbonic anhydrase II in complex with ethoxzolamide
4KNI 2013-11-06 1.8 Crystal structure of human carbonic anhydrase isozyme II with 2-Chloro-4-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide
4K0Z 2014-04-09 1.8 Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with methazolamide
4K0S 2014-04-09 1.8 Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with acetazolamide
3HKU 2009-10-13 1.8 Human carbonic anhydrase II in complex with topiramate
1G52 2000-11-08 1.8 CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL]-BENZAMIDE
3FFP 2009-08-18 1.81 X ray structure of the complex between carbonic anhydrase II and LC inhibitors
1XEG 2005-09-27 1.81 Crystal structure of human carbonic anhydrase II complexed with an acetate ion
2CBE 1993-10-31 1.82 STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES
4BF6 2014-01-22 1.82 Three dimensional structure of human carbonic anhydrase II in complex with 5-(1-(3-Cyanophenyl)-1H-1,2,3-triazol-4-yl)thiophene-2- sulfonamide
1G45 2000-11-08 1.83 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE
1G46 2000-11-08 1.84 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL]-BENZAMIDE
1I9M 2001-03-28 1.84 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4-DIFLUOROPHENYL)METHYL]-BENZAMIDE
1G4J 2000-11-08 1.84 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE
3EFT 2009-09-08 1.85 Crystal structure of the complex between Carbonic Anhydrase II and a spin-labeled sulfonamide incorporating TEMPO moiety
4PQ7 2014-10-08 1.85 The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide inhibitor
3V3H 2012-06-20 1.85 Kinetic and structural studies of thermostabilized mutants of HCA II.
1BV3 1999-09-28 1.85 HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH UREA
4MO8 2013-10-30 1.85 The crystal structure of the human carbonic anhydrase II in complex with N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide
4PXX 2015-06-10 1.85 Crystal structure of a highly thermal stabilized variant of Human Carbonic Anhydrase II
5FDI 2016-05-18 1.85 Crystal structure of Human Carbonic Anhydrase II with the anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog.
4FL7 2012-08-15 1.85 The crystal structure of human carbonic anhydrase II in complex with N-(Hydroxy)-benzamide
1H9N 1997-09-17 1.85 H119N CARBONIC ANHYDRASE II
3BET 2008-10-07 1.85 Crystal structure of the human carbonic anhydrase II in complex with STX 641 at 1.85 angstroms resolution
1G3Z 2000-11-08 1.86 CARBONIC ANHYDRASE II (F131V)
1I9O 2001-03-28 1.86 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4-TRIFLUOROPHENYL)METHYL]-BENZAMIDE
1G54 2000-11-08 1.86 CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE
1G48 2000-11-08 1.86 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE
3S77 2011-10-19 1.86 The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
1I9N 2001-03-28 1.86 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,5-DIFLUOROPHENYL)METHYL]-BENZAMIDE
3M2X 2011-05-25 1.87 Carbonic Anhydrase II in complex with novel sulfonamide inhibitor
1CAH 1993-10-31 1.88 STRUCTURE OF COBALT CARBONIC ANHYDRASE COMPLEXED WITH BICARBONATE
2CBC 1993-10-31 1.88 STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES
6EDA 2018-11-28 1.88 Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
6EBE 2018-11-28 1.88 Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
3B4F 2008-01-22 1.89 Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies
2X7T 2010-03-31 1.89 Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.
5LLH 2017-08-16 1.9 Crystal structure of human carbonic anhydrase isozyme II with 4-(1,3-Benzothiazol-2-ylthio)-2,3,5,6-tetrafluorobenzenesulfonamide
3BL0 2008-01-22 1.9 Carbonic anhydrase inhibitors. Interaction of 2-N,N-Dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies
3F4X 2009-03-17 1.9 Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules make the difference
2H15 2007-03-27 1.9 Carbonic anhydrase inhibitors: Clashing with Ala65 as a means of designing isozyme-selective inhibitors that show low affinity for the ubiquitous isozyme II
1CAO 1994-01-31 1.9 CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS
1CNX 1995-11-14 1.9 SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS
1CAJ 1993-10-31 1.9 STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
2CA2 1990-01-15 1.9 CRYSTALLOGRAPHIC STUDIES OF INHIBITOR BINDING SITES IN HUMAN CARBONIC ANHYDRASE II. A PENTACOORDINATED BINDING OF THE SCN-ION TO THE ZINC AT HIGH P*H
3DD8 2008-08-12 1.9 Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD-486019 with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies
1RZE 1993-10-31 1.9 X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES
1LGD 2002-07-24 1.9 Crystal Structure Analysis of HCA II Mutant T199P in Complex with Bicarbonate
5LLE 2017-08-16 1.9 Crystal structure of human carbonic anhydrase isozyme II with 4-(1-Adamantylamino)-2,3,5,6-tetrafluorobenzenesulfonamide
1F2W 2000-06-08 1.9 THE MECHANISM OF CYANAMIDE HYDRATION CATALYZED BY CARBONIC ANHYDRASE II REVEALED BY CRYOGENIC X-RAY DIFFRACTION
1YDB 1995-02-14 1.9 STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II
4JSZ 2013-06-19 1.9 Benzenesulfonamide bound to hCAII H94C
1CAN 1994-01-31 1.9 CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS
3MHL 2010-10-20 1.9 Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-methoxy-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide
5A25 2015-05-20 1.9 Rational engineering of a mesophilic carbonic anhydrase to an extreme halotolerant biocatalyst
1CAZ 1993-10-31 1.9 WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE
5JMZ 2017-05-03 1.9 Carbonic Anhydrase IX-mimic IN Complex WITH U-NO2
1RZD 1993-10-31 1.9 X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES
1RZA 1993-10-31 1.9 X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES
1BCD 1993-10-31 1.9 X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND A NEW TOPICAL INHIBITOR, TRIFLUOROMETHANE SULPHONAMIDE
1UGE 1997-04-01 1.9 HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY LEU (A65L)
1CAK 1993-10-31 1.9 STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
2H4N 1997-09-17 1.9 H94N CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE
1TG9 2005-01-25 1.9 Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
4JSW 2013-06-19 1.9 Human carbonic anhydrase II H94C
3K7K 2010-01-26 1.9 Crystal structure of the complex between Carbonic Anhydrase II and anions
6E8P 2019-04-03 1.9 CA IX mimic Complexed with Steroidal Sulfamate Compound STX 49
2HKK 2007-05-22 1.9 Carbonic anhydrase activators: Solution and X-ray crystallography for the interaction of andrenaline with various carbonic anhydrase isoforms
3RG3 2012-02-22 1.9 Crystal structure of the W5E mutant of human carbonic anhydrase II
1CRA 1994-01-31 1.9 THE COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND THE AROMATIC INHIBITOR 1,2,4-TRIAZOLE
2Q1Q 2007-09-11 1.9 Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies
1CNG 1995-07-10 1.9 X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
1BIC 1993-10-31 1.9 CRYSTALLOGRAPHIC ANALYSIS OF THR-200-> HIS HUMAN CARBONIC ANHYDRASE II AND ITS COMPLEX WITH THE SUBSTRATE, HCO3-
1RZC 1993-10-31 1.9 X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES
1RAZ 1993-10-31 1.9 THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE
1I9P 2001-03-28 1.92 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4,6-TRIFLUOROPHENYL)METHYL]-BENZAMIDE
1I9L 2001-03-28 1.93 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(4-FLUOROPHENYL)METHYL]-BENZAMIDE
1I8Z 2001-03-28 1.93 CARBONIC ANHYDRASE II COMPLEXED WITH AL-6629 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-METHOXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE
3IBI 2009-09-22 1.93 The crystal structure of the human carbonic anhydrase II in complex with an aliphatic sulfamate inhibitor
1IF4 2001-05-02 1.93 Carbonic Anhydrase II Complexed With 4-fluorobenzenesulfonamide
6H2Z 2018-12-19 1.94 The crystal structure of human carbonic anhydrase II in complex with 4-(4-phenylpiperidine-1-carbonyl)benzenesulfonamide.
1G53 2000-11-08 1.94 CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE
1IF8 2001-05-02 1.94 Carbonic Anhydrase II Complexed With (S)-N-(3-Indol-1-yl-2-methyl-propyl)-4-sulfamoyl-benzamide
1V9E 2004-02-10 1.95 Crystal Structure Analysis of Bovine Carbonic Anhydrase II
4QSI 2015-01-21 1.95 Crystal structure of human carbonic anhydrase isozyme II with 5-{[(4-tert-buthyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}-2-chlorobenzenesulfonamide
1YDC 1995-02-14 1.95 STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II
3M5T 2011-05-25 1.95 Fragment tethered to Carbonic Anhydrase II H64C mutant
2Q38 2007-10-02 1.95 Carbonic Anhydrase II in complex with Saccharin at 1.95 Angstrom
1TTM 2004-10-05 1.95 Human carbonic anhydrase II complexed with 667-coumate
1G4O 2000-11-08 1.96 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-PHENYLMETHYLBENZAMIDE
3K2F 2009-11-17 1.98 Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma
3S78 2011-10-19 1.98 The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
1IF7 2001-05-02 1.98 Carbonic Anhydrase II Complexed With (R)-N-(3-Indol-1-yl-2-methyl-propyl)-4-sulfamoyl-benzamide
5L3O 2017-03-01 1.98 Crystal Structure of Human Carbonic Anhydrase II in Complex with a Quinoline Oligoamide Foldamer
4M2R 2013-11-06 1.99 Human Carbonic Anhydrase II in complex with Brinzolamide
5EIJ 2016-11-09 1.99 Carbonic Anhydrase II in complex with Sulfonamide Inhibitor
3F8E 2009-10-06 2.0 Coumarins are a novel class of suicide carbonic anhydrase inhibitors
1CA2 1990-01-15 2.0 REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION
1IF9 2001-05-02 2.0 Carbonic Anhydrase II Complexed With N-[2-(1H-Indol-5-yl)-butyl]-4-sulfamoyl-benzamide
4KNJ 2013-11-06 2.0 Crystal structure of human carbonic anhydrase isozyme II with 2-Chloro-4-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide
2GEH 2006-06-20 2.0 N-Hydroxyurea, a versatile zinc binding function in the design of metalloenzyme inhibitors
3CA2 1990-01-15 2.0 CRYSTALLOGRAPHIC STUDIES OF INHIBITOR BINDING SITES IN HUMAN CARBONIC ANHYDRASE II. A PENTACOORDINATED BINDING OF THE SCN-ION TO THE ZINC AT HIGH P*H
3IEO 2010-01-26 2.0 The coumarin-binding site in carbonic anhydrase: the antiepileptic lacosamide as an example
3P4V 2011-04-20 2.0 Human carbonic anhydrase II in complex with (+)-Xylariamide A
1H4N 1997-09-17 2.0 H94N CARBONIC ANHYDRASE II COMPLEXED WITH TRIS
1HED 1992-10-15 2.0 STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II
1FSR 2001-01-17 2.0 X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT
1I91 2001-03-28 2.0 CARBONIC ANHYDRASE II COMPLEXED WITH AL-6619 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-HYDROXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE
1ZE8 2005-10-18 2.0 Carbonic anhydrase II in complex with a membrane-impermeant sulfonamide inhibitor
1FQM 2001-01-17 2.0 X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
1UGF 1997-04-01 2.0 HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY THR (A65T)
2ABE 2005-10-25 2.0 Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators
1ZSB 1996-07-11 2.0 CARBONIC ANHYDRASE II MUTANT E117Q, TRANSITION STATE ANALOGUE ACETAZOLAMIDE
1TE3 2005-01-25 2.0 Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
1UGA 1997-01-27 2.0 HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY PHE (A65F)
1TB0 2005-01-25 2.0 Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
1IF5 2001-05-02 2.0 Carbonic Anhydrase II Complexed With 2,6-difluorobenzenesulfonamide
1T9N 2005-01-25 2.0 Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
1TEU 2005-01-25 2.0 Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
1AVN 1997-12-24 2.0 HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH THE HISTAMINE ACTIVATOR
1UGD 1997-01-27 2.0 HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY SER (A65S)
3T84 2011-10-19 2.0 Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates
4Y0J 2015-04-22 2.0 H/D exchanged human carbonic anhydrase II pH 6 room temperature neutron crystal structure.
3KKX 2010-01-12 2.0 Neutron structure of human carbonic anhydrase II
6BBS 2018-02-28 2.0 Joint X-ray/neutron structure of human carbonic anhydrase II in complex with brinzolamide
1HEB 1992-10-15 2.0 STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II
3NJ9 2011-06-22 2.0 Crystal structure of carbonic anhydrase II in complex with a Nir inhibitor
4M2U 2013-11-06 2.0 Carbonic Anhydrase II in complex with Dorzolamide
3T82 2011-10-19 2.0 Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates
1HEC 1992-10-15 2.0 STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II
1UGC 1997-04-01 2.0 HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY HIS (A65H)
1FSQ 2001-01-17 2.0 X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT
4MLT 2014-07-02 2.0 Structure of a monodentate 3-hydroxy-4H-pyran-4-thione ligand bound to hCAII
1TBT 2005-01-25 2.0 Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
3V3F 2012-06-20 2.0 Kinetic and structural studies of thermostabilized mutants of HCA II.
1CNW 1995-11-14 2.0 SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS
1FSN 2001-01-17 2.0 X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT
3TMJ 2011-11-09 2.0 Joint X-ray/neutron structure of human carbonic anhydrase II at pH 7.8
4G0C 2012-09-19 2.0 Neutron structure of acetazolamide-bound human carbonic anhydrase II reveal molecular details of drug binding.
1UGB 1997-01-27 2.0 HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY GLY (A65G)
1AM6 1998-06-24 2.0 CARBONIC ANHYDRASE II INHIBITOR: ACETOHYDROXAMATE
1I90 2001-03-28 2.0 CARBONIC ANHYDRASE II COMPLEXED WITH AL-8520 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 4-AMINO-3,4-DIHYDRO-2-(3-METHOXYPROPYL)-, 1,1-DIOXIDE, (R)
5BNL 2015-07-15 2.0 Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins
1FQN 2001-01-17 2.0 X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
1FQR 2001-01-17 2.0 X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
2EZ7 2006-07-18 2.0 Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII and XIV with L- and D-histidine and crystallographic analysis of their adducts with isoform II: engineering proton transfer processes within the active site of an enzyme
1FQL 2001-01-17 2.0 X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
1TEQ 2005-01-25 2.0 Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
1HEA 1992-10-15 2.0 CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) (HCA II) (E.C.4.2.1.1) MUTANT WITH LEU 198 REPLACED BY ARG (L198R)
3KWA 2010-07-14 2.0 Polyamines inhibit carbonic anhydrases
3P55 2011-10-12 2.0 Human carbonic anhydrase II in complex with p-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide
4Z1E 2015-08-26 2.01 Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)
1XPZ 2005-05-17 2.02 Structure of human carbonic anhydrase II with 4-[4-O-sulfamoylbenzyl)(4-cyanophenyl)amino]-4H-[1,2,4]-triazole
4CNW 2015-02-04 2.03 Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture
1G1D 2000-11-08 2.04 CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE
4L5U 2014-04-30 2.05 The structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II
1CNH 1995-07-10 2.05 X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
5FNG 2016-03-02 2.05 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
1IF6 2001-05-02 2.09 Carbonic Anhydrase II Complexed With 3,5-difluorobenzenesulfonamide
2WEH 2009-11-10 2.09 Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors
1YDA 1995-02-14 2.1 STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II
4CA2 1992-10-31 2.1 ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II
3RGE 2012-02-22 2.1 Crystal structure of the W5H mutant of human carbonic anhydrase II
3NI5 2011-06-22 2.1 Carbonic anhydrase inhibitor: C1 family
1CIM 1994-01-31 2.1 THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS
1YDD 1995-02-14 2.1 STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II
1EOU 2002-02-13 2.1 CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH AN ANTICONVULSANT SUGAR SULFAMATE
5CA2 1992-10-31 2.1 CONFORMATIONAL MOBILITY OF HIS-64 IN THE THR-200 (RIGHT ARROW) SER MUTANT OF HUMAN CARBONIC ANHYDRASE II
1BN1 1999-05-18 2.1 CARBONIC ANHYDRASE II INHIBITOR
1DCB 1993-07-15 2.1 STRUCTURE OF AN ENGINEERED METAL BINDING SITE IN HUMAN CARBONIC ANHYDRASE II REVEALS THE ARCHITECTURE OF A REGULATORY CYSTEINE SWITCH
1CIN 1994-01-31 2.1 THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS
3BL1 2008-07-01 2.1 Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited old leads for new applications
1OKL 1997-01-11 2.1 CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKL INHIBITOR 5-DIMETHYLAMINO-NAPHTHALENE-1-SULFONAMIDE
2HOC 2006-10-10 2.1 Crystal structure of the human carbonic anhydrase II in complex with the 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide inhibitor
1BN4 1999-05-18 2.1 CARBONIC ANHYDRASE II INHIBITOR
1CAY 1993-10-31 2.1 WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE
2O4Z 2007-05-15 2.1 Crystal structure of the Carbonic Anhydrase II complexed with hydroxysulfamide inhibitor
3HFP 2010-05-19 2.1 Crystal structure of teh complex between CA II and the activator MAI
2X7U 2010-03-31 2.12 Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.
1BNT 1999-06-15 2.15 CARBONIC ANHYDRASE II INHIBITOR
5UMC 2017-12-06 2.15 Synthesis of novel seleno ureido containing compounds as SLC-0111 analogs. Investigations on carbonic anhydrases activity, glutathione peroxidase and X-ray crystallography
1CNK 1995-07-10 2.15 X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
1BNU 1999-06-15 2.15 CARBONIC ANHYDRASE II INHIBITOR
4LP6 2013-10-23 2.15 Crystal Structure of Human Carbonic Anhydrase II in complex with a quinoline oligoamide foldamer
1CAL 1993-10-31 2.2 STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
1H9Q 1997-09-17 2.2 H119Q CARBONIC ANHYDRASE II
1XEV 2005-09-20 2.2 Crystal structure of human carbonic anhydrase II in a new crystal form
3IBN 2009-09-22 2.2 The crystal structure of the human carbonic anhydrase II in complex with an aliphatic bis-sulfamate inhibitor
1CCT 1995-02-07 2.2 STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY
1DCA 1993-07-15 2.2 STRUCTURE OF AN ENGINEERED METAL BINDING SITE IN HUMAN CARBONIC ANHYDRASE II REVEALS THE ARCHITECTURE OF A REGULATORY CYSTEINE SWITCH
1CVD 1994-12-20 2.2 STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE
3P44 2011-10-12 2.2 Human carbonic anhydrase II in complex with p-(4-ruthenocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide
1BN3 1999-05-18 2.2 CARBONIC ANHYDRASE II INHIBITOR
1CNC 1994-10-15 2.2 COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES
5CAC 1994-01-31 2.2 REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION
1OKM 1997-01-11 2.2 CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKM INHIBITOR 4-SULFONAMIDE-[1-(4-AMINOBUTANE)]BENZAMIDE
5L70 2017-06-21 2.2 CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER
4CAC 1994-01-31 2.2 REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION
1UGG 1997-01-27 2.2 HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY SER (A65S)-ORTHORHOMBIC FORM
1LG6 2002-07-24 2.2 Crystal Structure Analysis of HCA II Mutant T199P in Complex with Thiocyanate
6ECZ 2018-11-28 2.21 Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
1KWR 2003-01-07 2.25 HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH INHIBITOR 0134-36
1A42 1999-03-23 2.25 HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH BRINZOLAMIDE
1CVF 1994-11-30 2.25 STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE
1CVE 1994-11-30 2.25 STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE
1BNW 1999-06-15 2.25 CARBONIC ANHYDRASE II INHIBITOR
1CVA 1993-10-31 2.25 STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II
1CCU 1995-02-07 2.25 STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY
4CNR 2015-02-04 2.29 Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture
1CVH 1995-02-07 2.3 STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE
1CA3 1992-10-15 2.3 UNEXPECTED PH-DEPENDENT CONFORMATION OF HIS-64, THE PROTON SHUTTLE OF CARBONIC ANHYDRASE II.
1BNN 1999-05-18 2.3 CARBONIC ANHYDRASE II INHIBITOR
1CNY 1995-11-14 2.3 SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS
1HCA 1992-10-15 2.3 UNEXPECTED PH-DEPENDENT CONFORMATION OF HIS-64, THE PROTON SHUTTLE OF CARBONIC ANHYDRASE II.
1CVC 1994-01-31 2.3 REDESIGNING THE ZINC BINDING SITE OF HUMAN CARBONIC ANHYDRASE II: STRUCTURE OF A HIS2ASP-ZN2+ METAL COORDINATION POLYHEDRON
1LZV 2002-10-23 2.3 Site-Specific Mutant (Tyr7 replaced with His) of Human Carbonic Anhydrase II
1HVA 1993-10-31 2.3 ENGINEERING THE ZINC BINDING SITE OF HUMAN CARBONIC ANHYDRASE II: STRUCTURE OF THE HIS-94-> CYS APOENZYME IN A NEW CRYSTALLINE FORM
1CCS 1995-02-07 2.35 STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY
1CNB 1994-10-15 2.35 COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES
3HKT 2009-10-13 2.36 Human carbonic anhydrase II in complex with alpha-D-Glucopyranosyl-(1->4)-1-thio-beta-D-glucopyranosylsulfonamide
12CA 1992-10-15 2.4 ALTERING THE MOUTH OF A HYDROPHOBIC POCKET. STRUCTURE AND KINETICS OF HUMAN CARBONIC ANHYDRASE II MUTANTS AT RESIDUE VAL-121
1OKN 1997-01-11 2.4 CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKN INHIBITOR 4-SULFONAMIDE-[1-(4-N-(5-FLUORESCEIN THIOUREA)BUTANE)]
3T85 2011-10-19 2.4 Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates
7CA2 1992-07-15 2.4 ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II
1BNV 1999-02-16 2.4 CARBONIC ANHYDRASE II INHIBITOR
1BNQ 1999-06-15 2.4 CARBONIC ANHYDRASE II INHIBITOR
8CA2 1992-07-15 2.4 ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II
1CVB 1993-10-31 2.4 STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II
6CA2 1992-07-15 2.5 ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II
1ZSA 1996-07-11 2.5 CARBONIC ANHYDRASE II MUTANT E117Q, APO FORM
1KWQ 2003-01-07 2.6 HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH INHIBITOR 2000-07
1BNM 1999-05-18 2.6 CARBONIC ANHYDRASE II INHIBITOR
5L6T 2017-06-21 2.65 CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER
9CA2 1992-07-15 2.8 ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II
5L9E 2017-06-21 2.9 CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER
1V9I 2004-02-10 2.95 Crystal Structure Analysis of the site specific mutant (Q253C) of bovine carbonic anhydrase II
1G6V 2000-11-22 3.5 Complex of the camelid heavy-chain antibody fragment CAB-CA05 with bovine carbonic anhydrase

Relevant UniProtKB Entries

Percent Identity Matching Chains Protein Accession Entry Name
100.0 Carbonic anhydrase 2 P86277 BIOR_THESB
92.3 Carbonic anhydrase 2 P00922 CAH2_SHEEP
100.0 Carbonic anhydrase 2 P00921 CAH2_BOVIN
100.0 A Carbonic anhydrase 2 P00918 CAH2_HUMAN