A general rule for the relationship between hydrophobic effect and conformational stability of a protein: stability and structure of a series of hydrophobic mutants of human lysozyme.


Abstract

To get a general rule for the relationship between hydrophobic effect and conformational stability, five Ile to Val and nine Val to Ala mutants (3SS mutants) from 3SS (C77A/C95A) human lysozyme were constructed. As known from previous studies, the 3SS protein lacking a disulfide bond between Cys77 and Cys95 is destabilized by enthalpic factors, as revealed by a decrease of about 20 kJ/mol in the denaturation Gibbs energy change (DeltaG) value, as compared to the wild-type protein, which has four disulfide bonds. In this study, the stabilities and structures of the 3SS mutants were determined by differential scanning calorimetry and X-ray crystal analysis, respectively, and compared with those of the mutants (4SS mutants) from the wild-type (4SS) protein published previously. The stabilities of all the 3SS mutants, except for V110A-3SS were decreased as compared with that of the 3SS protein, coinciding with the results for the 4SS mutants. The change in the denaturation Gibbs energy change (DeltaDeltaG) values of the 3SS mutants relative to the 3SS protein at the denaturation temperature (49.2 degreesC) of the 3SS protein at pH 2.7 were similar to those of the equivalent 4SS mutants relative to the wild-type at 64.9 degreesC. The Delta DeltaG values of the 3SS mutants correlated with the changes in hydrophobic surface area exposed upon denaturation (Delta DeltaASAHP) for all of the hydrophobic residues when the effects of the secondary structure propensity were considered. This correlation is identical with that previously found for the 4SS mutants. The linear relation between Delta DeltaG and Delta DeltaASAHP for all of the hydrophobic residues with the same slope was found also for the mutants of T4 lysozyme already reported, indicating that this is a general relationship between changes in conformational stability and changes in ASA values of hydrophobic residues due to mutations. Study holds ProTherm entries: 3384, 3385, 3386, 3387, 3388, 3389, 3390, 3391, 3392, 3393, 3394, 3395, 3396, 3397, 3398, 4247, 4248, 4249, 4250, 4251, 4252, 4253, 4254, 4255, 4256, 4257, 4258, 4259, 4260, 4261, 4262, 4263, 4264, 4265, 4266, 4267, 4268, 4269, 4270, 4271, 4272, 4273, 4274, 4275, 4276, 4277, 4278, 4279, 4280, 4281, 4282, 4283, 4284, 4285, 4286, 4287, 4288, 4289, 4290, 4291, 4292, 4293, 4294, 4295, 4296, 4297, 4298, 4299, 4300, 4301, 4302, 4303, 4304, 4305, 4306, 4307, 4308, 4309, 4310, 4311, 4312, 4313, 4314, 4315, 14189, 14190, 14191, 14192, 14193, 14194, 14195, 14196, 14197, 14198, 14199, 14200, 14201, 14202 Extra Details: pseudo wild type human lysozyme, 1LHM (C77A, C95A) protein stability; hydrophobic effect; double mutant;,disulfide bond; human lysozyme

Submission Details

ID: dhrbFumS

Submitter: Connie Wang

Submission Date: April 24, 2018, 8:21 p.m.

Version: 1

Publication Details
Takano K;Yamagata Y;Yutani K,J. Mol. Biol. (1998) A general rule for the relationship between hydrophobic effect and conformational stability of a protein: stability and structure of a series of hydrophobic mutants of human lysozyme. PMID:9677301
Additional Information

Study Summary

Number of data points 301
Proteins Lysozyme C ; Lysozyme C ; Lysozyme C ; Lysozyme C ; Lysozyme C ; Lysozyme C ; Lysozyme C ; Lysozyme C ; Lysozyme C ; Lysozyme C ; Lysozyme C ; Lysozyme C ; Actin ; Lysozyme C ; Lysozyme C ; Lysozyme C ; Lysozyme C ; Lysozyme C ; Lysozyme C ; Lysozyme C ; Lysozyme C ; Lysozyme C ; Lysozyme C ; Lysozyme C ; Lysozyme C ; Lysozyme C ; Lysozyme C
Unique complexes 15
Assays/Quantities/Protocols Experimental Assay: dHvH pH:2.73 ; Experimental Assay: dHcal pH:2.87 ; Experimental Assay: Tm pH:2.87 ; Experimental Assay: dHvH pH:2.87 ; Experimental Assay: dHcal pH:3.13 ; Experimental Assay: Tm pH:3.13 ; Experimental Assay: dHvH pH:3.13 ; Experimental Assay: dHcal pH:2.9 ; Experimental Assay: Tm pH:2.9 ; Experimental Assay: dHvH pH:2.9 ; Experimental Assay: dHcal pH:3.15 ; Experimental Assay: Tm pH:3.15 ; Experimental Assay: dHvH pH:3.15 ; Experimental Assay: dHcal pH:2.54 ; Experimental Assay: Tm pH:2.54 ; Experimental Assay: dHvH pH:2.54 ; Experimental Assay: dHcal pH:2.72 ; Experimental Assay: Tm pH:2.72 ; Experimental Assay: dHvH pH:2.72 ; Experimental Assay: dHcal pH:2.5 ; Experimental Assay: Tm pH:2.5 ; Experimental Assay: dHvH pH:2.5 ; Experimental Assay: dHcal pH:2.88 ; Experimental Assay: Tm pH:2.88 ; Experimental Assay: dHvH pH:2.88 ; Experimental Assay: dHcal pH:2.51 ; Experimental Assay: Tm pH:2.51 ; Experimental Assay: dHvH pH:2.51 ; Experimental Assay: dHcal pH:2.69 ; Experimental Assay: Tm pH:2.69 ; Experimental Assay: dHvH pH:2.69 ; Experimental Assay: dHcal pH:2.85 ; Experimental Assay: Tm pH:2.85 ; Experimental Assay: dHvH pH:2.85 ; Experimental Assay: dHcal pH:3.03 ; Experimental Assay: Tm pH:3.03 ; Experimental Assay: dHvH pH:3.03 ; Experimental Assay: dHcal pH:3.16 ; Experimental Assay: Tm pH:3.16 ; Experimental Assay: dHvH pH:3.16 ; Experimental Assay: dHcal pH:2.71 ; Experimental Assay: Tm pH:2.71 ; Experimental Assay: dHvH pH:2.71 ; Experimental Assay: dHcal pH:3.02 ; Experimental Assay: Tm pH:3.02 ; Experimental Assay: dHvH pH:3.02 ; Experimental Assay: dHcal pH:2.79 ; Experimental Assay: Tm pH:2.79 ; Experimental Assay: dHvH pH:2.79 ; Experimental Assay: dHcal pH:2.68 ; Experimental Assay: Tm pH:2.68 ; Experimental Assay: dHvH pH:2.68 ; Experimental Assay: dCp temp:49.2 C, ionic:-: - ; Experimental Assay: ddG ; Experimental Assay: dHcal pH:2.82 ; Experimental Assay: Tm pH:2.82 ; Experimental Assay: dHvH pH:2.82 ; Experimental Assay: dHcal pH:2.97 ; Experimental Assay: Tm pH:2.97 ; Experimental Assay: dHvH pH:2.97 ; Experimental Assay: dHcal pH:3.17 ; Experimental Assay: Tm pH:3.17 ; Experimental Assay: dHvH pH:3.17 ; Experimental Assay: dHcal pH:2.86 ; Experimental Assay: Tm pH:2.86 ; Experimental Assay: dHvH pH:2.86 ; Experimental Assay: dHcal pH:2.55 ; Experimental Assay: Tm pH:2.55 ; Experimental Assay: dHvH pH:2.55 ; Experimental Assay: dHcal pH:2.73 ; Experimental Assay: Tm pH:2.73 ; Experimental Assay: dHcal pH:2.8 ; Experimental Assay: Tm pH:2.8 ; Experimental Assay: dHvH pH:2.8 ; Experimental Assay: dHcal pH:3.0 ; Experimental Assay: Tm pH:3.0 ; Experimental Assay: dHvH pH:3.0 ; Experimental Assay: dHcal pH:3.1 ; Experimental Assay: Tm pH:3.1 ; Experimental Assay: dHvH pH:3.1 ; Experimental Assay: dHcal pH:2.49 ; Experimental Assay: Tm pH:2.49 ; Experimental Assay: dHvH pH:2.49 ; Experimental Assay: dHcal pH:2.66 ; Experimental Assay: Tm pH:2.66 ; Experimental Assay: dHvH pH:2.66 ; Experimental Assay: dHcal pH:2.78 ; Experimental Assay: Tm pH:2.78 ; Experimental Assay: dHvH pH:2.78 ; Experimental Assay: dHcal pH:2.96 ; Experimental Assay: Tm pH:2.96 ; Experimental Assay: dHvH pH:2.96 ; Experimental Assay: dHcal pH:3.09 ; Experimental Assay: Tm pH:3.09 ; Experimental Assay: dHvH pH:3.09 ; Experimental Assay: dHcal pH:2.53 ; Experimental Assay: Tm pH:2.53 ; Experimental Assay: dHvH pH:2.53 ; Experimental Assay: dHvH pH:2.7 ; Experimental Assay: dHcal pH:2.81 ; Experimental Assay: Tm pH:2.81 ; Experimental Assay: dHvH pH:2.81 ; Experimental Assay: dHcal pH:3.04 ; Experimental Assay: Tm pH:3.04 ; Experimental Assay: dHvH pH:3.04 ; Experimental Assay: dHcal pH:3.14 ; Experimental Assay: Tm pH:3.14 ; Experimental Assay: dHvH pH:3.14 ; Experimental Assay: dHcal pH:2.7 ; Experimental Assay: Tm pH:2.7 ; Experimental Assay: dCp ionic:: ; Derived Quantity: dTm pH:2.53 ; Derived Quantity: dTm pH:3.14 ; Derived Quantity: dTm pH:2.81 ; Derived Quantity: dTm pH:2.7
Libraries Mutations for sequence KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV

Structure view and single mutant data analysis

Study data

No weblogo for data of varying length.
Colors: D E R H K S T N Q A V I L M F Y W C G P
 

Data Distribution

Studies with similar sequences (approximate matches)

Correlation with other assays (exact sequence matches)


Relevant PDB Entries

Structure ID Release Date Resolution Structure Title
5H3N 2017-11-01 Solution structure of human Gelsolin protein domain 1 at pH 7.3
5H3M 2017-11-01 Solution structure of human Gelsolin protein domain 1 at pH 5.0
1IY4 2002-07-31 Solution structure of the human lysozyme at 35 degree C
1IY3 2002-07-31 Solution Structure of the Human lysozyme at 4 degree C
1SOL 1996-03-08 A PIP2 AND F-ACTIN-BINDING SITE OF GELSOLIN, RESIDUE 150-169 (NMR, AVERAGED STRUCTURE)
2NWD 2006-12-19 1.04 Structure of chemically synthesized human lysozyme at 1 Angstrom resolution
5FAF 2016-10-05 1.05 N184K pathological variant of gelsolin domain 2 (orthorhombic form)
5LSH 2017-06-21 1.06 human lysozyme in complex with a tetrasaccharide fragment of the O-chain of LPS from Klebsiella pneumoniae
1JSF 1998-04-29 1.15 FULL-MATRIX LEAST-SQUARES REFINEMENT OF HUMAN LYSOZYME
6I4E 2019-06-26 1.22 Crystal Structure of Plasmodium falciparum actin I in the Mg-ADP state
6I4D 2019-06-26 1.24 Crystal Structure of Plasmodium falciparum actin I in the Mg-K-ATP/ADP state
4CBU 2014-04-30 1.3 Crystal structure of Plasmodium falciparum actin I
1IWY 2002-09-04 1.4 Crystal Structure Analysis of Human lysozyme at 170K.
1IWV 2002-09-04 1.4 Crystal Structure Analysis of Human lysozyme at 147K.
1IWU 2002-09-04 1.4 Crystal Structure Analysis of Human lysozyme at 127K.
1JWR 2001-09-19 1.4 Crystal structure of human lysozyme at 100 K
6I4H 2019-06-26 1.4 Crystal Structure of Plasmodium falciparum actin I (F54Y mutant) in the Ca-ATP state
1IWW 2002-09-04 1.4 Crystal Structure Analysis of Human lysozyme at 152K.
5MVV 2017-07-12 1.4 Crystal structure of Plasmodium falciparum actin I- gelsolin segment 1 -CdATP complex
1IWT 2002-09-04 1.4 Crystal Structure Analysis of Human lysozyme at 113K.
1IWX 2002-09-04 1.4 Crystal Structure Analysis of Human lysozyme at 161K.
1IWZ 2002-09-04 1.48 Crystal Structure Analysis of Human lysozyme at 178K.
6I4J 2019-06-26 1.5 Crystal Structure of Plasmodium falciparum actin I (F54Y mutant) in the Mg-ADP state
1REX 1997-02-12 1.5 NATIVE HUMAN LYSOZYME
6I4F 2019-06-26 1.5 Crystal Structure of Plasmodium falciparum actin I (A272W mutant) in the Mg-K-ATP/ADP state
1LZR 1995-04-20 1.5 STRUCTURAL CHANGES OF THE ACTIVE SITE CLEFT AND DIFFERENT SACCHARIDE BINDING MODES IN HUMAN LYSOZYME CO-CRYSTALLIZED WITH HEXA-N-ACETYL-CHITOHEXAOSE AT PH 4.0
3FE0 2009-12-08 1.5 X-ray crystal structure of wild type human lysozyme in D2O
1LZ1 1985-01-02 1.5 REFINEMENT OF HUMAN LYSOZYME AT 1.5 ANGSTROMS RESOLUTION. ANALYSIS OF NON-BONDED AND HYDROGEN-BOND INTERACTIONS
4R0P 2014-12-17 1.52 Ifqins, an amyloid forming segment from human lysozyme spanning residues 56-61
2FH1 2006-06-13 1.55 C-terminal half of gelsolin soaked in low calcium at pH 4.5
1LMT 1995-03-31 1.6 STRUCTURE OF A CONFORMATIONALLY CONSTRAINED ARG-GLY-ASP SEQUENCE INSERTED INTO HUMAN LYSOZYME
1LZS 1995-04-20 1.6 STRUCTURAL CHANGES OF THE ACTIVE SITE CLEFT AND DIFFERENT SACCHARIDE BINDING MODES IN HUMAN LYSOZYME CO-CRYSTALLIZED WITH HEXA-N-ACETYL-CHITOHEXAOSE AT PH 4.0
3CIP 2008-08-19 1.6 Complex of Dictyostelium Discoideum Actin with Gelsolin
1JKC 1997-05-15 1.6 HUMAN LYSOZYME MUTANT WITH TRP 109 REPLACED BY PHE
1KCQ 2002-01-04 1.65 Human Gelsolin Domain 2 with a Cd2+ bound
1JKA 1997-05-15 1.66 HUMAN LYSOZYME MUTANT WITH GLU 35 REPLACED BY ASP
1JKB 1997-05-15 1.66 HUMAN LYSOZYME MUTANT WITH GLU 35 REPLACED BY ALA
1REZ 1997-02-12 1.7 HUMAN LYSOZYME-N-ACETYLLACTOSAMINE COMPLEX
1TCY 1993-01-15 1.7 DISSECTION OF THE FUNCTIONAL ROLE OF STRUCTURAL ELEMENTS OF TYROSINE-63 IN THE CATALYTIC ACTION OF HUMAN LYSOZYME
5FAE 2016-10-05 1.7 N184K pathological variant of gelsolin domain 2 (trigonal form)
1REY 1997-02-12 1.7 HUMAN LYSOZYME-N,N'-DIACETYLCHITOBIOSE COMPLEX
1TAY 1993-01-15 1.7 DISSECTION OF THE FUNCTIONAL ROLE OF STRUCTURAL ELEMENTS OF TYROSINE-63 IN THE CATALYTIC ACTION OF HUMAN LYSOZYME
5O2Z 2017-11-08 1.7 Domain swap dimer of the G167R variant of gelsolin second domain
3CI5 2008-08-19 1.7 Complex of Phosphorylated Dictyostelium Discoideum Actin with Gelsolin
1GE1 2000-11-08 1.7 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT LEFT-HANDED HELICAL POSITIONS
1TDY 1993-01-15 1.7 DISSECTION OF THE FUNCTIONAL ROLE OF STRUCTURAL ELEMENTS OF TYROSINE-63 IN THE CATALYTIC ACTION OF HUMAN LYSOZYME
1D4X 2001-05-02 1.75 Crystal Structure of Caenorhabditis Elegans Mg-ATP Actin Complexed with Human Gelsolin Segment 1 at 1.75 A resolution.
1LAA 1993-01-15 1.77 X-RAY STRUCTURE OF GLU 53 HUMAN LYSOZYME
1TBY 1993-01-15 1.77 DISSECTION OF THE FUNCTIONAL ROLE OF STRUCTURAL ELEMENTS OF TYROSINE-63 IN THE CATALYTIC ACTION OF HUMAN LYSOZYME
133L 1993-10-31 1.77 ROLE OF ARG 115 IN THE CATALYTIC ACTION OF HUMAN LYSOZYME. X-RAY STRUCTURE OF HIS 115 AND GLU 115 MUTANTS
134L 1993-10-31 1.77 ROLE OF ARG 115 IN THE CATALYTIC ACTION OF HUMAN LYSOZYME. X-RAY STRUCTURE OF HIS 115 AND GLU 115 MUTANTS
1IP4 2001-11-14 1.8 G72A HUMAN LYSOZYME
1CKD 1999-04-30 1.8 T43V MUTANT HUMAN LYSOZYME
1YAN 1996-04-03 1.8 CONTRIBUTION OF HYDROPHOBIC RESIDUES TO THE STABILITY OF HUMAN LYSOZYME: CALORIMETRIC STUDIES AND X-RAY STRUCTURAL ANALYSIS OF THE FIVE ISOLEUCINE TO VALINE MUTANTS
1EQ5 2000-04-19 1.8 CRYSTAL STRUCTURES OF SALT BRIDGE MUTANTS OF HUMAN LYSOZYME
1HNL 1995-02-14 1.8 CRYSTAL STRUCTURE OF A GLUTATHIONYLATED HUMAN LYSOZYME: A FOLDING INTERMEDIATE MIMIC IN THE FORMATION OF A DISULFIDE BOND
1LHI 1994-01-31 1.8 ROLE OF PROLINE RESIDUES IN HUMAN LYSOZYME STABILITY: A SCANNING CALORIMETRIC STUDY COMBINED WITH X-RAY STRUCTURE ANALYSIS OF PROLINE MUTANTS
1OUE 1997-02-12 1.8 CONTRIBUTION OF HYDROPHOBIC RESIDUES TO THE STABILITY OF HUMAN LYSOZYME: X-RAY STRUCTURE OF THE V125A MUTANT
1LOZ 1997-04-01 1.8 AMYLOIDOGENIC VARIANT (I56T) VARIANT OF HUMAN LYSOZYME
1EQE 2000-04-19 1.8 CRYSTAL STRUCTURES OF SALT BRIDGE MUTANTS OF HUMAN LYSOZYME
1NM1 2003-01-21 1.8 Crystal Structure of D. Dicsoideum Actin Complexed With Gelsolin Segment 1 and Mg ATP at 1.8 A Resolution
1CJ6 1999-04-30 1.8 T11A MUTANT HUMAN LYSOZYME
2HED 1998-01-14 1.8 CONTRIBUTION OF WATER MOLECULES IN THE INTERIOR OF A PROTEIN TO THE CONFORMATIONAL STABILITY
2BQM 1998-08-12 1.8 CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
1GAZ 2000-07-27 1.8 Crystal Structure of Mutant Human Lysozyme Substituted at the Surface Positions
1B7R 1999-02-02 1.8 VERIFICATION OF SPMP USING MUTANT HUMAN LYSOZYMES
1I1Z 2001-02-28 1.8 MUTANT HUMAN LYSOZYME (Q86D)
1GF0 2001-04-18 1.8 BURIED POLAR MUTANT HUMAN LYSOZYME
1LHK 1994-01-31 1.8 ROLE OF PROLINE RESIDUES IN HUMAN LYSOZYME STABILITY: A SCANNING CALORIMETRIC STUDY COMBINED WITH X-RAY STRUCTURE ANALYSIS OF PROLINE MUTANTS
3LHM 1992-04-15 1.8 CRYSTAL STRUCTURES OF THE APO-AND HOLOMUTANT HUMAN LYSOZYMES WITH AN INTRODUCED CA2+ BINDING SITE
1GF7 2001-04-18 1.8 BURIED POLAR MUTANT HUMAN LYSOZYME
2ZIL 2009-01-06 1.8 Crystal Structure of Human Lysozyme from Urine
1GFR 2000-12-27 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1I22 2001-02-28 1.8 MUTANT HUMAN LYSOZYME (A83K/Q86D/A92D)
2BQO 1998-08-12 1.8 CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
1GFJ 2000-12-20 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1LHJ 1994-01-31 1.8 ROLE OF PROLINE RESIDUES IN HUMAN LYSOZYME STABILITY: A SCANNING CALORIMETRIC STUDY COMBINED WITH X-RAY STRUCTURE ANALYSIS OF PROLINE MUTANTS
2BQG 1998-08-12 1.8 CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
2HEA 1998-01-14 1.8 CONTRIBUTION OF WATER MOLECULES IN THE INTERIOR OF A PROTEIN TO THE CONFORMATIONAL STABILITY
1GB0 2000-07-27 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1B7N 1999-01-27 1.8 VERIFICATION OF SPMP USING MUTANT HUMAN LYSOZYMES
1OUH 1997-02-12 1.8 CONTRIBUTION OF HYDROPHOBIC RESIDUES TO THE STABILITY OF HUMAN LYSOZYME: X-RAY STRUCTURE OF THE V74A MUTANT
1GF8 2000-12-20 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1GB9 2000-07-27 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1YAP 1996-04-03 1.8 CONTRIBUTION OF HYDROPHOBIC RESIDUES TO THE STABILITY OF HUMAN LYSOZYME: CALORIMETRIC STUDIES AND X-RAY STRUCTURAL ANALYSIS OF THE FIVE ISOLEUCINE TO VALINE MUTANTS
1YAQ 1996-04-03 1.8 CONTRIBUTION OF HYDROPHOBIC RESIDUES TO THE STABILITY OF HUMAN LYSOZYME: CALORIMETRIC STUDIES AND X-RAY STRUCTURAL ANALYSIS OF THE FIVE ISOLEUCINE TO VALINE MUTANTS
1GF4 2001-04-18 1.8 BURIED POLAR MUTANT HUMAN LYSOZYME
1GBX 2000-07-27 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1GE0 2000-11-08 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT LEFT-HANDED HELICAL POSITIONS
1GFK 2000-12-20 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1GB5 2000-07-27 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1WQN 1998-07-01 1.8 CONTRIBUTION OF HYDROGEN BONDS TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
2HEE 1998-01-14 1.8 CONTRIBUTION OF WATER MOLECULES IN THE INTERIOR OF A PROTEIN TO THE CONFORMATIONAL STABILITY
1LZ5 1993-10-31 1.8 STRUCTURAL AND FUNCTIONAL ANALYSES OF THE ARG-GLY-ASP SEQUENCE INTRODUCED INTO HUMAN LYSOZYME
2BQB 1998-08-12 1.8 CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
2BQF 1998-08-12 1.8 CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
1CJ9 1999-04-30 1.8 T40V MUTANT HUMAN LYSOZYME
1GFU 2000-12-27 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1GDX 2000-11-08 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT LEFT-HANDED HELICAL POSITIONS
2MED 1998-07-15 1.8 CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
1B7O 1999-02-02 1.8 VERIFICATION OF SPMP USING MUTANT HUMAN LYSOZYMES
1GBW 2000-07-27 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1LYY 1997-04-01 1.8 AMYLOIDOGENIC VARIANT (ASP67HIS) OF HUMAN LYSOZYME
1IP3 2001-11-14 1.8 G68A HUMAN LYSOZYME
1C45 1999-08-20 1.8 MUTANT HUMAN LYSOZYME WITH FOREIGN N-TERMINAL RESIDUES
1YAO 1996-04-03 1.8 CONTRIBUTION OF HYDROPHOBIC RESIDUES TO THE STABILITY OF HUMAN LYSOZYME: CALORIMETRIC STUDIES AND X-RAY STRUCTURAL ANALYSIS OF THE FIVE ISOLEUCINE TO VALINE MUTANTS
1GDW 2000-11-01 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT LEFT-HANDED HELICAL POSITIONS
1INU 2000-12-20 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1LZ6 1993-10-31 1.8 STRUCTURAL AND FUNCTIONAL ANALYSES OF THE ARG-GLY-ASP SEQUENCE INTRODUCED INTO HUMAN LYSOZYME
4PKG 2014-07-30 1.8 Complex of ATP-actin With the N-terminal Actin-Binding Domain of Tropomodulin
1OUF 1997-02-12 1.8 CONTRIBUTION OF HYDROPHOBIC RESIDUES TO THE STABILITY OF HUMAN LYSOZYME: X-RAY STRUCTURE OF THE V130A MUTANT
1GAY 2000-06-29 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1CKC 1999-04-30 1.8 T43A MUTANT HUMAN LYSOZYME
207L 1996-10-14 1.8 MUTANT HUMAN LYSOZYME C77A
1GBZ 2000-07-27 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1GFG 2000-12-20 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1IP6 2001-11-14 1.8 G127A HUMAN LYSOZYME
1GB6 2000-07-27 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
4ML7 2014-07-23 1.8 Crystal structure of Brucella abortus PliC in complex with human lysozyme
1CKF 1999-04-30 1.8 T52A MUTANT HUMAN LYSOZYME
1B7L 1999-01-27 1.8 VERIFICATION OF SPMP USING MUTANT HUMAN LYSOZYMES
1GB3 2000-07-27 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1JKD 1997-05-15 1.8 HUMAN LYSOZYME MUTANT WITH TRP 109 REPLACED BY ALA
2BQH 1998-08-12 1.8 CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
2BQN 1998-08-12 1.8 CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
1OUB 1997-02-12 1.8 CONTRIBUTION OF HYDROPHOBIC RESIDUES TO THE STABILITY OF HUMAN LYSOZYME: X-RAY STRUCTURE OF THE V100A MUTANT
2MEB 1998-07-15 1.8 CHANGES IN CONFORMATIONAL STABILITY OF A SERIES OF MUTANT HUMAN LYSOZYMES AT CONSTANT POSITIONS
2BQD 1998-08-12 1.8 CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
1OUA 1997-02-12 1.8 CONTRIBUTION OF HYDROPHOBIC RESIDUES TO THE STABILITY OF HUMAN LYSOZYME: X-RAY STRUCTURE OF THE I56T MUTANT
1GB8 2000-07-27 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1C43 1999-08-20 1.8 MUTANT HUMAN LYSOZYME WITH FOREIGN N-TERMINAL RESIDUES
1B5U 1999-01-20 1.8 CONTRIBUTION OF HYDROGEN BONDS TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME: CALORIMETRY AND X-RAY ANALYSIS OF SIX SER->ALA MUTANT
1WQQ 1998-07-01 1.8 CONTRIBUTION OF HYDROGEN BONDS TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
2MEE 1998-07-15 1.8 CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
1IP2 2001-11-14 1.8 G48A HUMAN LYSOZYME
1OUJ 1997-02-12 1.8 CONTRIBUTION OF HYDROPHOBIC RESIDUES TO THE STABILITY OF HUMAN LYSOZYME: X-RAY STRUCTURE OF THE V99A MUTANT
1OUG 1997-02-12 1.8 CONTRIBUTION OF HYDROPHOBIC RESIDUES TO THE STABILITY OF HUMAN LYSOZYME: X-RAY STRUCTURE OF THE V2A MUTANT
1IP1 2001-11-14 1.8 G37A HUMAN LYSOZYME
2BQL 1998-08-12 1.8 CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
1GF5 2001-04-18 1.8 BURIED POLAR MUTANT HUMAN LYSOZYME
1GF3 2001-04-18 1.8 BURIED POLAR MUTANT HUMAN LYSOZYME
1GE4 2000-11-08 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT LEFT-HANDED HELICAL POSITIONS
1WQM 1998-07-01 1.8 CONTRIBUTION OF HYDROGEN BONDS TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
1OUD 1997-02-12 1.8 CONTRIBUTION OF HYDROPHOBIC RESIDUES TO THE STABILITY OF HUMAN LYSOZYME: X-RAY STRUCTURE OF THE V121A MUTANT
2BQC 1998-08-12 1.8 CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
1EQ4 2000-04-19 1.8 CRYSTAL STRUCTURES OF SALT BRIDGE MUTANTS OF HUMAN LYSOZYME
1GBY 2000-07-27 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1WQP 1998-07-01 1.8 CONTRIBUTION OF HYDROGEN BONDS TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
1GBO 2000-07-27 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
2BQA 1998-08-12 1.8 CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
1WQO 1998-07-01 1.8 CONTRIBUTION OF HYDROGEN BONDS TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
1IX0 2003-07-22 1.8 I59A-3SS human lysozyme
1WQR 1998-07-01 1.8 CONTRIBUTION OF HYDROGEN BONDS TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
1GFV 2000-12-27 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
2LHM 1992-04-15 1.8 CRYSTAL STRUCTURES OF THE APO-AND HOLOMUTANT HUMAN LYSOZYMES WITH AN INTRODUCED CA2+ BINDING SITE
1GB7 2000-07-27 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1CJ7 1999-04-30 1.8 T11V MUTANT HUMAN LYSOZYME
1GE3 2000-11-08 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT LEFT-HANDED HELICAL POSITIONS
1GFA 2000-12-20 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1OUC 1997-02-12 1.8 CONTRIBUTION OF HYDROPHOBIC RESIDUES TO THE STABILITY OF HUMAN LYSOZYME: X-RAY STRUCTURE OF THE V110A MUTANT
2MEH 1998-07-15 1.8 CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
1OUI 1997-02-12 1.8 CONTRIBUTION OF HYDROPHOBIC RESIDUES TO THE STABILITY OF HUMAN LYSOZYME: X-RAY STRUCTURE OF THE V93A MUTANT
2BQE 1998-08-12 1.8 CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
1GFE 2000-12-20 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1DI3 1999-12-08 1.8 ROLE OF AMINO ACID RESIDUES AT TURNS IN THE CONFORMATIONAL STABILITY AND FOLDING OF HUMAN LYSOZYME
1LHM 1992-04-15 1.8 THE CRYSTAL STRUCTURE OF A MUTANT LYSOZYME C77(SLASH)95A WITH INCREASED SECRETION EFFICIENCY IN YEAST
1LHL 1994-01-31 1.8 ROLE OF PROLINE RESIDUES IN HUMAN LYSOZYME STABILITY: A SCANNING CALORIMETRIC STUDY COMBINED WITH X-RAY STRUCTURE ANALYSIS OF PROLINE MUTANTS
1LZ4 1993-10-31 1.8 ENTHALPIC DESTABILIZATION OF A MUTANT HUMAN LYSOZYME LACKING A DISULFIDE BRIDGE BETWEEN CYSTEINE-77 AND CYSTEINE-95
1GFH 2000-12-20 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
2BQI 1998-08-12 1.8 CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
1LHH 1994-01-31 1.8 ROLE OF PROLINE RESIDUES IN HUMAN LYSOZYME STABILITY: A SCANNING CALORIMETRIC STUDY COMBINED WITH X-RAY STRUCTURE ANALYSIS OF PROLINE MUTANTS
2BQK 1998-08-12 1.8 CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
1IP5 2001-11-14 1.8 G105A HUMAN LYSOZYME
1GEZ 2001-04-18 1.8 BURIED POLAR MUTANT HUMAN LYSOZYME
2HEC 1998-01-14 1.8 CONTRIBUTION OF WATER MOLECULES IN THE INTERIOR OF A PROTEIN TO THE CONFORMATIONAL STABILITY
1NLV 2003-01-21 1.8 Crystal Structure Of Dictyostelium Discoideum Actin Complexed With Ca ATP And Human Gelsolin Segment 1
2MEI 1998-07-15 1.8 CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
1YAM 1996-04-03 1.8 CONTRIBUTION OF HYDROPHOBIC RESIDUES TO THE STABILITY OF HUMAN LYSOZYME: CALORIMETRIC STUDIES AND X-RAY STRUCTURAL ANALYSIS OF THE FIVE ISOLEUCINE TO VALINE MUTANTS
1CJ8 1999-04-30 1.8 T40A MUTANT HUMAN LYSOZYME
2MEG 1998-07-15 1.8 CHANGES IN CONFORMATIONAL STABILITY OF A SERIES OF MUTANT HUMAN LYSOZYMES AT CONSTANT POSITIONS.
1GB2 2000-07-27 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
2ZWB 2009-12-08 1.8 Neutron crystal structure of wild type human lysozyme in D2O
2BQJ 1998-08-12 1.8 CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
2MEF 1998-07-15 1.8 CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
2HEF 1998-01-14 1.8 CONTRIBUTION OF WATER MOLECULES IN THE INTERIOR OF A PROTEIN TO THE CONFORMATIONAL STABILITY
1GFT 2000-12-27 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
1GF6 2001-04-18 1.8 BURIED POLAR MUTANT HUMAN LYSOZYME
1GF9 2000-12-20 1.8 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS
2ZIK 2009-01-06 1.81 Crystal Structure of Human Lysozyme from Pichia pastoris
6I4L 2019-06-26 1.83 Crystal Structure of Plasmodium falciparum actin I (G115A mutant) in the Mg-K-ATP/ADP state
6I4K 2019-06-26 1.83 Crystal Structure of Plasmodium falciparum actin I (G115A mutant) in the Ca-ATP state
3EBA 2008-12-02 1.85 CAbHul6 FGLW mutant (humanized) in complex with human lysozyme
1QSW 2001-08-08 1.85 CRYSTAL STRUCTURE ANALYSIS OF A HUMAN LYSOZYME MUTANT W64C C65A
1OP9 2003-10-14 1.86 Complex of human lysozyme with camelid VHH HL6 antibody fragment
6I4M 2019-06-26 1.87 Crystal Structure of Plasmodium berghei actin II in the Mg-ADP state
1IP7 2001-11-14 1.9 G129A HUMAN LYSOZYME
1YAG 1999-10-09 1.9 STRUCTURE OF THE YEAST ACTIN-HUMAN GELSOLIN SEGMENT 1 COMPLEX
6H1F 2019-01-23 1.9 Structure of the nanobody-stabilized gelsolin D187N variant (second domain)
6I4I 2019-06-26 1.9 Crystal Structure of Plasmodium falciparum actin I (F54Y mutant) in the Mg-K-ADP-AlFn state
1I20 2001-02-28 1.9 MUTANT HUMAN LYSOZYME (A92D)
1NMD 2003-02-04 1.9 Crystal Structure of D. Discoideum Actin-Gelsolin Segment 1 Complex Crystallized In Presence Of Lithium ATP
2ZIJ 2009-01-06 1.9 Crystal Structure of Human Lysozyme Expressed in E. coli.
4I0C 2013-10-09 1.95 The structure of the camelid antibody cAbHuL5 in complex with human lysozyme
1D6Q 2000-01-21 1.96 HUMAN LYSOZYME E102 MUTANT LABELLED WITH 2',3'-EPOXYPROPYL GLYCOSIDE OF N-ACETYLLACTOSAMINE
6I4G 2019-06-26 2.0 Crystal Structure of Plasmodium falciparum actin I (H74Q) in the Mg-K-ATP state
1B5X 1999-01-20 2.0 Contribution of hydrogen bonds to the conformational stability of human lysozyme: calorimetry and x-ray analysis of six ser->ala mutants
1P8X 2003-10-14 2.0 The Calcium-Activated C-terminal half of gelsolin
1B7Q 1999-02-02 2.0 VERIFICATION OF SPMP USING MUTANT HUMAN LYSOZYMES
1C0G 2000-03-01 2.0 CRYSTAL STRUCTURE OF 1:1 COMPLEX BETWEEN GELSOLIN SEGMENT 1 AND A DICTYOSTELIUM/TETRAHYMENA CHIMERA ACTIN (MUTANT 228: Q228K/T229A/A230Y/E360H)
2FF3 2006-03-21 2.0 Crystal structure of Gelsolin domain 1:N-wasp V2 motif hybrid in complex with actin
1ESV 2000-07-19 2.0 COMPLEX BETWEEN LATRUNCULIN A:RABBIT MUSCLE ALPHA ACTIN:HUMAN GELSOLIN DOMAIN 1
1T44 2004-09-07 2.0 Structural basis of actin sequestration by thymosin-B4: Implications for arp2/3 activation
1UBZ 2003-04-22 2.0 Crystal structure of Glu102-mutant human lysozyme doubly labeled with 2',3'-epoxypropyl beta-glycoside of N-acetyllactosamine
1GE2 2000-11-08 2.0 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT LEFT-HANDED HELICAL POSITIONS
1DI4 1999-12-08 2.0 ROLE OF AMINO ACID RESIDUES AT TURNS IN THE CONFORMATIONAL STABILITY AND FOLDING OF HUMAN LYSOZYME
1CKH 1999-04-30 2.0 T70V MUTANT HUMAN LYSOZYME
1B7P 1999-01-25 2.0 VERIFICATION OF SPMP USING MUTANT HUMAN LYSOZYMES
1B7S 1999-02-02 2.0 VERIFICATION OF SPMP USING MUTANT HUMAN LYSOZYMES
3LN2 2011-02-16 2.04 Crystal Structure of a Charge Engineered Human Lysozyme Variant
2FF6 2006-03-21 2.05 Crystal structure of Gelsolin domain 1:ciboulot domain 2 hybrid in complex with actin
1REM 1998-07-15 2.1 HUMAN LYSOZYME WITH MAN-B1,4-GLCNAC COVALENTLY ATTACHED TO ASP53
1YVN 2000-03-23 2.1 THE YEAST ACTIN VAL 159 ASN MUTANT COMPLEX WITH HUMAN GELSOLIN SEGMENT 1.
1GEV 2001-04-18 2.1 BURIED POLAR MUTANT HUMAN LYSOZYME
4PKH 2014-07-30 2.15 Complex of ADP-actin With the N-terminal Actin-Binding Domain of Tropomodulin
1B5V 1999-01-20 2.17 CONTRIBUTION OF HYDROGEN BONDS TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME: CALORIMETRY AND X-RAY ANALYSIS OF SIX SER->ALA MUTANTS
1B5W 1999-01-20 2.17 CONTRIBUTION OF HYDROGEN BONDS TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME: CALORIMETRY AND X-RAY ANALYSIS OF SIX SER->ALA MUTANTS
2HEB 1998-01-28 2.2 CONTRIBUTION OF WATER MOLECULES IN THE INTERIOR OF A PROTEIN TO THE CONFORMATIONAL STABILITY
1MDU 2003-01-07 2.2 Crystal structure of the chicken actin trimer complexed with human gelsolin segment 1 (GS-1)
2MEA 1998-07-15 2.2 CHANGES IN CONFORMATIONAL STABILITY OF A SERIES OF MUTANT HUMAN LYSOZYMES AT CONSTANT POSITIONS
1C46 1999-08-20 2.2 MUTANT HUMAN LYSOZYME WITH FOREIGN N-TERMINAL RESIDUES
1B5Z 1999-02-02 2.2 CONTRIBUTION OF HYDROGEN BONDS TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME: CALORIMETRY AND X-RAY ANALYSIS OF SIX SER->ALA MUTANTS
1CKG 1999-05-05 2.2 T52V MUTANT HUMAN LYSOZYME
2MEC 1998-07-15 2.2 CHANGES IN CONFORMATIONAL STABILITY OF A SERIES OF MUTANT HUMAN LYSOZYMES AT CONSTANT POSITIONS
4CBX 2014-04-30 2.2 Crystal structure of Plasmodium berghei actin II
1B7M 1999-01-27 2.2 VERIFICATION OF SPMP USING MUTANT HUMAN LYSOZYMES
1B5Y 1999-01-20 2.2 CONTRIBUTION OF HYDROGEN BONDS TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME: CALORIMETRY AND X-RAY ANALYSIS OF SIX SER->ALA MUTANTS
208L 1996-10-14 2.2 MUTANT HUMAN LYSOZYME C77A
1DI5 1999-12-08 2.2 ROLE OF AMINO ACID RESIDUES AT TURNS IN THE CONFORMATIONAL STABILITY AND FOLDING OF HUMAN LYSOZYME
1D6P 2000-01-21 2.23 HUMAN LYSOZYME L63 MUTANT LABELLED WITH 2',3'-EPOXYPROPYL N,N'-DIACETYLCHITOBIOSE
4PL7 2014-10-22 2.3 Structure of Komagataella pastoris actin-thymosin beta4 hybrid
1EQY 2000-05-03 2.3 COMPLEX BETWEEN RABBIT MUSCLE ALPHA-ACTIN: HUMAN GELSOLIN DOMAIN 1
4PKI 2014-07-30 2.3 Complex of ATP-actin With the C-terminal Actin-Binding Domain of Tropomodulin
1RE2 1999-05-05 2.3 HUMAN LYSOZYME LABELLED WITH TWO 2',3'-EPOXYPROPYL BETA-GLYCOSIDE OF N-ACETYLLACTOSAMINE
3A5N 2010-10-27 2.36 Crystal Structure of a Dictyostelium P109A Ca2+-Actin in Complex with Human Gelsolin Segment 1
5UBO 2017-12-20 2.39 Mical-oxidized Actin complex with Gelsolin Segment 1
1C0F 2000-03-01 2.4 CRYSTAL STRUCTURE OF DICTYOSTELIUM CAATP-ACTIN IN COMPLEX WITH GELSOLIN SEGMENT 1
3A5O 2010-10-27 2.4 Crystal Structure of a Dictyostelium P109I Ca2+-Actin in Complex with Human Gelsolin Segment 1
3A5M 2010-10-27 2.4 Crystal Structure of a Dictyostelium P109I Mg2+-Actin in Complex with Human Gelsolin Segment 1
1DEJ 2000-03-01 2.4 CRYSTAL STRUCTURE OF A DICTYOSTELIUM/TETRAHYMENA CHIMERA ACTIN (MUTANT 646: Q228K/T229A/A230Y/A231K/S232E/E360H) IN COMPLEX WITH HUMAN GELSOLIN SEGMENT 1
3A5L 2010-10-27 2.4 Crystal Structure of a Dictyostelium P109A Mg2+-Actin in Complex with Human Gelsolin Segment 1
1IOC 2002-10-09 2.4 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME, EAEA-I56T
1C7P 2000-04-05 2.4 CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME WITH FOUR EXTRA RESIDUES (EAEA) AT THE N-TERMINAL
4Z94 2015-10-21 2.4 Actin Complex With a Chimera of Tropomodulin-1 and Leiomodin-1 Actin-Binding Site 2
5LVK 2016-09-28 2.49 Human Lysozyme soaked with [H2Ind][trans-RuCl4(DMSO)(HInd)]
4CBW 2014-04-30 2.5 Crystal structure of Plasmodium berghei actin I with D-loop from muscle actin
1D0N 1999-09-15 2.5 THE CRYSTAL STRUCTURE OF CALCIUM-FREE EQUINE PLASMA GELSOLIN.
2FH2 2006-06-13 2.5 C-terminal half of gelsolin soaked in EGTA at pH 4.5
1W08 2004-06-10 2.5 STRUCTURE OF T70N HUMAN LYSOZYME
5DD2 2016-10-05 2.6 Human gelsolin from residues Glu28 to Arg161 with Calcium
1P8Z 2003-10-14 2.6 Complex Between Rabbit Muscle alpha-Actin: Human Gelsolin Residues Val26-Glu156
4S10 2015-06-03 2.61 Gelsolin nanobody shielding mutant plasma gelsolin from furin proteolysis
5ZZ0 2019-06-05 2.63 HUMAN GELSOLIN FROM RESIDUES GLU28 TO ARG161 WITH CALCIUM
2FGH 2006-04-18 2.8 ATP bound gelsolin
5I9E 2016-07-27 2.8 Crystal structure of a nuclear actin ternary complex
5NBL 2018-08-22 2.8 Crystal structure of the Arp4-N-actin(APO-state) heterodimer bound by a nanobody
2FH3 2006-06-13 2.87 C-terminal half of gelsolin soaked in low calcium at pH 8
6JCO 2019-06-12 2.88 Crystal structure of calcium free human gelsolin amyloid mutant D187N
6JEH 2019-06-12 2.95 Crystal structure of calcium free human gelsolin amyloid mutant D187Y
6JEG 2019-06-12 2.97 Crystal structure of calcium free human gelsolin amyloid mutant G167R
1H1V 2003-01-24 2.99 gelsolin G4-G6/actin complex
1RGI 2004-07-27 3.0 Crystal structure of gelsolin domains G1-G3 bound to actin
3FFK 2009-10-06 3.0 Crystal structure of human Gelsolin domains G1-G3 bound to Actin
3TU5 2012-09-26 3.0 Actin complex with Gelsolin Segment 1 fused to Cobl segment
3FFN 2009-10-06 3.0 Crystal structure of calcium-free human gelsolin
2FH4 2006-06-13 3.0 C-terminal half of gelsolin soaked in EGTA at pH 8
1NPH 2003-05-13 3.0 Gelsolin Domains 4-6 in Active, Actin Free Conformation Identifies Sites of Regulatory Calcium Ions
3CJB 2008-03-25 3.21 Actin dimer cross-linked by V. cholerae MARTX toxin and complexed with Gelsolin-segment 1
5NBM 2018-08-22 3.4 Crystal structure of the Arp4-N-actin(ATP-state) heterodimer bound by a nanobody
3CJC 2008-03-25 3.9 Actin dimer cross-linked by V. cholerae MARTX toxin and complexed with DNase I and Gelsolin-segment 1
5NBN 2018-08-22 4.0 Crystal structure of the Arp4-N-actin-Arp8-Ino80HSA module of INO80
5Y81 2018-04-18 4.7 NuA4 TEEAA sub-complex

Relevant UniProtKB Entries

Percent Identity Matching Chains Protein Accession Entry Name
96.9 Lysozyme C P79180 LYSC_HYLLA
99.2 Lysozyme C P79239 LYSC_PONPY
100.0 Lysozyme C P61628 LYSC_PANTR
100.0 Lysozyme C P61627 LYSC_PANPA
100.0 Lysozyme C P61626 LYSC_HUMAN
100.0 Lysozyme C P79179 LYSC_GORGO
97.6 G Actin Q68FP1 GELS_RAT
97.6 G Actin P13020 GELS_MOUSE
98.4 G Actin Q28372 GELS_HORSE
99.2 G Actin P20305 GELS_PIG
99.2 G Actin Q3SX14 GELS_BOVIN
100.0 G Actin P06396 GELS_HUMAN
93.8 A Actin Q24733 ACT_DICVI
95.6 A Actin P85911 ACT1_PSEMZ
90.6 A Actin Q39596 ACT_OXYRB
90.8 A Actin P00544 FGR_FSVGR
96.4 A Actin P10982 ACT1_ABSGL
90.9 A Actin Q11212 ACT_SPOLI
91.2 A Actin Q99023 ACT_HYPJE
95.0 A Actin A5DQP9 ACT_PICGU
90.4 A Actin P48465 ACT_CRYNH
90.7 A Actin P26197 ACT2_ABSGL
91.5 A Actin Q9URS0 ACTG_PENCH
91.7 A Actin Q8X119 ACT_EXODE
92.0 A Actin P53455 ACT_AJECG
92.0 A Actin P20359 ACTG_EMENI
92.0 A Actin P78711 ACT_NEUCR
92.0 A Actin Q6TCF2 ACT_GAEGA
92.0 A Actin Q9UVW9 ACTG_ACRCH
92.3 A Actin O13419 ACT_BOTFU
93.9 A Actin Q9P4D1 ACT_KOMPG
94.6 A Actin P14235 ACT_CANAX
94.9 A Actin Q9UVZ8 ACT_CANDC
96.0 A Actin O74258 ACT_OGAPD
97.3 A Actin P17128 ACT_KLULA
98.9 A Actin Q75D00 ACT_ASHGO
100.0 A Actin P60010 ACT_YEAST
100.0 A Actin P60011 ACT_SACBA
100.0 A Actin P60009 ACT_CANGA