Pepsinogen denaturation is not a two-state transition.


Abstract

Study holds ProTherm entries: 3063 Extra Details: van't Hoff enthalpy is 131.0 kcal/mol and the ratio is 2.0 pepsinogen; thermal denaturation; heat capacity; calorimetry

Submission Details

ID: YiibpgTr

Submitter: Connie Wang

Submission Date: April 24, 2018, 8:21 p.m.

Version: 1

Publication Details
Mateo PL;Privalov PL,FEBS Lett. (1981) Pepsinogen denaturation is not a two-state transition. PMID:7227510
Additional Information

Structure view and single mutant data analysis

Study data

No weblogo for data of varying length.
Colors: D E R H K S T N Q A V I L M F Y W C G P
 

Data Distribution

Studies with similar sequences (approximate matches)

Correlation with other assays (exact sequence matches)


Relevant PDB Entries

Structure ID Release Date Resolution Structure Title
1YX9 2005-02-20T00:00:00+0000 3.0 Effect of Dimethyl Sulphoxide on the crystal structure of Porcine Pepsin
1F34 2000-05-31T00:00:00+0000 2.45 CRYSTAL STRUCTURE OF ASCARIS PEPSIN INHIBITOR-3 BOUND TO PORCINE PEPSIN
5PEP 1990-05-30T00:00:00+0000 2.34 X-RAY ANALYSES OF ASPARTIC PROTEASES. II. THREE-DIMENSIONAL STRUCTURE OF THE HEXAGONAL CRYSTAL FORM OF PORCINE PEPSIN AT 2.3 ANGSTROMS RESOLUTION
2PSG 1991-01-23T00:00:00+0000 1.8 REFINED STRUCTURE OF PORCINE PEPSINOGEN AT 1.8 ANGSTROMS RESOLUTION
1PSA 1991-10-22T00:00:00+0000 2.9 STRUCTURE OF A PEPSIN(SLASH)RENIN INHIBITOR COMPLEX REVEALS A NOVEL CRYSTAL PACKING INDUCED BY MINOR CHEMICAL ALTERATIONS IN THE INHIBITOR
4PEP 1989-12-18T00:00:00+0000 1.8 THE MOLECULAR AND CRYSTAL STRUCTURES OF MONOCLINIC PORCINE PEPSIN REFINED AT 1.8 ANGSTROMS RESOLUTION
6XCT 2020-06-09T00:00:00+0000 1.99 Porcine pepsin in complex with amprenavir
6XCY 2020-06-09T00:00:00+0000 2.05 Porcine pepsin in complex with ritonavir
3PSG 1991-09-03T00:00:00+0000 1.65 THE HIGH RESOLUTION CRYSTAL STRUCTURE OF PORCINE PEPSINOGEN
6XCZ 2020-06-09T00:00:00+0000 1.89 Porcine pepsin in complex with saquinavir

Relevant UniProtKB Entries

Percent Identity Matching Chains Protein Accession Entry Name
100.0 Gastricsin P30879 PEPC_PIG
99.5 Pepsin A P00791 PEPA_PIG