Pepsinogen denaturation is not a two-state transition.


Abstract

Study holds ProTherm entries: 3063 Extra Details: van't Hoff enthalpy is 131.0 kcal/mol and the ratio is 2.0 pepsinogen; thermal denaturation; heat capacity; calorimetry

Submission Details

ID: YiibpgTr

Submitter: Connie Wang

Submission Date: April 24, 2018, 8:21 p.m.

Version: 1

Publication Details
Mateo PL;Privalov PL,FEBS Lett. (1981) Pepsinogen denaturation is not a two-state transition. PMID:7227510
Additional Information

Structure view and single mutant data analysis

Study data

No weblogo for data of varying length.
Colors: D E R H K S T N Q A V I L M F Y W C G P
 

Data Distribution

Studies with similar sequences (approximate matches)

Correlation with other assays (exact sequence matches)


Relevant PDB Entries

Structure ID Release Date Resolution Structure Title
3PSG 1993-01-15 1.65 THE HIGH RESOLUTION CRYSTAL STRUCTURE OF PORCINE PEPSINOGEN
2PSG 1992-10-15 1.8 REFINED STRUCTURE OF PORCINE PEPSINOGEN AT 1.8 ANGSTROMS RESOLUTION
4PEP 1990-04-15 1.8 THE MOLECULAR AND CRYSTAL STRUCTURES OF MONOCLINIC PORCINE PEPSIN REFINED AT 1.8 ANGSTROMS RESOLUTION
3PEP 1990-04-15 2.3 REVISED 2.3 ANGSTROMS STRUCTURE OF PORCINE PEPSIN. EVIDENCE FOR A FLEXIBLE SUBDOMAIN
5PEP 1990-07-15 2.34 X-RAY ANALYSES OF ASPARTIC PROTEASES. II. THREE-DIMENSIONAL STRUCTURE OF THE HEXAGONAL CRYSTAL FORM OF PORCINE PEPSIN AT 2.3 ANGSTROMS RESOLUTION
1F34 2001-02-01 2.45 CRYSTAL STRUCTURE OF ASCARIS PEPSIN INHIBITOR-3 BOUND TO PORCINE PEPSIN
1PSA 1994-01-31 2.9 STRUCTURE OF A PEPSIN(SLASH)RENIN INHIBITOR COMPLEX REVEALS A NOVEL CRYSTAL PACKING INDUCED BY MINOR CHEMICAL ALTERATIONS IN THE INHIBITOR
1YX9 2005-05-24 3.0 Effect of Dimethyl Sulphoxide on the crystal structure of Porcine Pepsin

Relevant UniProtKB Entries

Percent Identity Matching Chains Protein Accession Entry Name
100.0 Gastricsin P30879 PEPC_PIG
99.5 Pepsin A P00791 PEPA_PIG