Equilibrium and kinetics of the denaturation of a homogeneous human immunoglobulin light chain.


Abstract

Study holds ProTherm entries: 7327 Extra Details: denaturation equlibrium; kinetics; Wes L chain;,domain hypothesis

Submission Details

ID: XNwZqfY3

Submitter: Connie Wang

Submission Date: April 24, 2018, 8:33 p.m.

Version: 1

Publication Details
Rowe ES;Tanford C,Biochemistry (1973) Equilibrium and kinetics of the denaturation of a homogeneous human immunoglobulin light chain. PMID:4761969
Additional Information

Structure view and single mutant data analysis

Study data

No weblogo for data of varying length.
Colors: D E R H K S T N Q A V I L M F Y W C G P
 

Data Distribution

Studies with similar sequences (approximate matches)

Correlation with other assays (exact sequence matches)


Relevant PDB Entries

Structure ID Release Date Resolution Structure Title
2ATY 2006-01-31 Complement receptor chimaeric conjugate CR2-Ig
1P7K 2004-05-11 1.75 Crystal structure of an anti-ssDNA antigen-binding fragment (Fab) bound to 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid (HEPES)
1SEQ 2005-03-01 1.78 Fab MNAC13
1ORS 2003-05-06 1.9 X-ray structure of the KvAP potassium channel voltage sensor in complex with an Fab
1R3J 2003-11-25 1.9 potassium channel KcsA-Fab complex in high concentration of Tl+
1KEL 1996-12-07 1.9 CATALYTIC ANTIBODY 28B4 FAB FRAGMENT COMPLEXED WITH HAPTEN (1-[N-4'-NITROBENZYL-N-4'-CARBOXYBUTYLAMINO] METHYLPHOSPHONIC ACID)
1GPO 1998-04-01 1.95 CRYSTAL STRUCTURE OF THE RATIONALLY DESIGNED ANTIBODY M41 AS A FAB FRAGMENT
1A3L 1999-02-16 1.95 CATALYSIS OF A DISFAVORED REACTION: AN ANTIBODY EXO DIELS-ALDERASE-TSA-INHIBITOR COMPLEX AT 1.95 A RESOLUTION
1BM3 1999-04-20 2.0 IMMUNOGLOBULIN OPG2 FAB-PEPTIDE COMPLEX
1P2C 2004-02-17 2.0 crystal structure analysis of an anti-lysozyme antibody
1FNS 2000-10-18 2.0 CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR (VWF) A1 DOMAIN I546V MUTANT IN COMPLEX WITH THE FUNCTION BLOCKING FAB NMC4
25C8 1999-03-23 2.0 CATALYTIC ANTIBODY 5C8, FAB-HAPTEN COMPLEX
1OPG 1995-07-31 2.0 OPG2 FAB FRAGMENT
1CLO 1997-05-15 2.1 ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY A5B7
1KCU 2002-05-11 2.2 CRYSTAL STRUCTURE OF ANTIBODY PC287
1CT8 1999-11-10 2.2 CATALYTIC ANTIBODY 7C8 COMPLEX
1KEM 1996-12-07 2.2 CATALYTIC ANTIBODY 28B4 FAB FRAGMENT
1OAK 1998-10-21 2.2 CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR (VWF) A1 DOMAIN IN COMPLEX WITH THE FUNCTION BLOCKING NMC-4 FAB
1EMT 2000-11-01 2.25 FAB ANTIBODY FRAGMENT OF AN C60 ANTIFULLERENE ANTIBODY
1K4D 2001-11-14 2.3 Potassium Channel KcsA-Fab complex in low concentration of K+
1A0Q 1999-03-02 2.3 29G11 COMPLEXED WITH PHENYL [1-(1-N-SUCCINYLAMINO)PENTYL] PHOSPHONATE
1R3I 2003-11-25 2.4 potassium channel KcsA-Fab complex in Rb+
1R3L 2003-11-25 2.41 potassium channel KcsA-Fab complex in Cs+
1FDL 1991-10-15 2.5 CRYSTALLOGRAPHIC REFINEMENT OF THE THREE-DIMENSIONAL STRUCTURE OF THE FAB D1.3-LYSOZYME COMPLEX AT 2.5-ANGSTROMS RESOLUTION
1CIC 1999-04-19 2.5 IDIOTOPE-ANTI-IDIOTOPE FAB-FAB COMPLEX; D1.3-E225
1MLC 1995-06-03 2.5 MONOCLONAL ANTIBODY FAB D44.1 RAISED AGAINST CHICKEN EGG-WHITE LYSOZYME COMPLEXED WITH LYSOZYME
1RIH 2004-01-13 2.5 Crystal Structure of Fab 14F7, a unique anti-tumor antibody specific for N-glycolyl GM3
15C8 1999-03-23 2.5 CATALYTIC ANTIBODY 5C8, FREE FAB
1KC5 2002-07-24 2.5 CRYSTAL STRUCTURE OF ANTIBODY PC287 IN COMPLEX WITH PS1 PEPTIDE
1CK0 2003-08-05 2.5 ANTI-ANTI-IDIOTYPIC ANTIBODY AGAINST HUMAN ANGIOTENSIN II, UNLIGANDED FORM
1MF2 1997-12-31 2.6 ANTI HIV1 PROTEASE FAB COMPLEX
1C12 1999-08-14 2.6 INSIGHT IN ODORANT PERCEPTION: THE CRYSTAL STRUCTURE AND BINDING CHARACTERISTICS OF ANTIBODY FRAGMENTS DIRECTED AGAINST THE MUSK ODORANT TRASEOLIDE
1S5I 2004-05-25 2.7 Fab (LNKB-2) of monoclonal antibody to Human Interleukin-2, crystal structure
1DBM 1994-01-31 2.7 MOLECULAR BASIS OF CROSS-REACTIVITY AND THE LIMITS OF ANTIBODY-ANTIGEN COMPLEMENTARITY
1DBB 1993-10-31 2.7 THREE-DIMENSIONAL STRUCTURE OF AN ANTI-STEROID FAB' AND PROGESTERONE-FAB' COMPLEX
1DBJ 1994-01-31 2.7 MOLECULAR BASIS OF CROSS-REACTIVITY AND THE LIMITS OF ANTIBODY-ANTIGEN COMPLEMENTARITY
1R3K 2003-11-25 2.8 potassium channel KcsA-Fab complex in low concentration of Tl+
1DBA 1993-10-31 2.8 THREE-DIMENSIONAL STRUCTURE OF AN ANTI-STEROID FAB' AND PROGESTERONE-FAB' COMPLEX
1AI1 1997-05-15 2.8 HIV-1 V3 LOOP MIMIC
1R0A 2004-08-03 2.8 Crystal structure of HIV-1 reverse transcriptase covalently tethered to DNA template-primer solved to 2.8 angstroms
1QFU 1999-04-16 2.8 INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY
1JRH 1998-03-25 2.8 COMPLEX (ANTIBODY/ANTIGEN)
2DBL 1994-03-07 2.9 MOLECULAR BASIS OF CROSS-REACTIVITY AND THE LIMITS OF ANTIBODY-ANTIGEN COMPLEMENTARITY
1KCR 2002-05-11 2.9 CRYSTAL STRUCTURE OF ANTIBODY PC283 IN COMPLEX WITH PS1 PEPTIDE
1CL7 2000-01-12 3.0 ANTI HIV1 PROTEASE FAB
1N6Q 2003-01-14 3.0 HIV-1 Reverse Transcriptase Crosslinked to pre-translocation AZTMP-terminated DNA (complex N)
1ACY 1994-07-31 3.0 CRYSTAL STRUCTURE OF THE PRINCIPAL NEUTRALIZING SITE OF HIV-1
1FBI 1995-02-27 3.0 CRYSTAL STRUCTURE OF A CROSS-REACTION COMPLEX BETWEEN FAB F9.13.7 AND GUINEA-FOWL LYSOZYME
1DBK 1994-01-31 3.0 MOLECULAR BASIS OF CROSS-REACTIVITY AND THE LIMITS OF ANTIBODY-ANTIGEN COMPLEMENTARITY
1N5Y 2003-01-28 3.1 HIV-1 Reverse Transcriptase Crosslinked to Post-Translocation AZTMP-Terminated DNA (Complex P)
1YED 1997-10-15 3.1 STRUCTURE OF A CATALYTIC ANTIBODY IGG2A FAB FRAGMENT (D2.4)
1IGY 1998-04-15 3.2 STRUCTURE OF IMMUNOGLOBULIN
1KEN 2002-04-24 3.5 INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION
1NTL 2004-02-03 30.0 Model of mouse Crry-Ig determined by solution scattering, curve fitting and homology modelling

Relevant UniProtKB Entries

Percent Identity Matching Chains Protein Accession Entry Name
100.0 Ig gamma-1 chain C region secreted form P01869 IGH1M_MOUSE
100.0 Ig gamma-1 chain C region secreted form P01868 IGHG1_MOUSE