Enhanced protein thermostability from site-directed mutations that decrease the entropy of unfolding.


Abstract

It is proposed that the stability of a protein can be increased by selected amino acid substitutions that decrease the configurational entropy of unfolding. Two such substitutions, one of the form Xaa----Pro and the other of the form Gly----Xaa, were constructed in bacteriophage T4 lysozyme at sites consistent with the known three-dimensional structure. Both substitutions stabilize the protein toward reversible and irreversible thermal denaturation at physiological pH. The substitutions have no effect on enzymatic activity. High-resolution crystallographic analysis of the proline-containing mutant protein (Ala-82----Pro) shows that its three-dimensional structure is essentially identical with the wild-type enzyme. The overall structure of the other mutant enzyme (Gly-77----Ala) is also very similar to wild-type lysozyme, although there are localized conformational adjustments in the vicinity of the altered amino acid. The combination of a number of such amino acid replacements, each of which is expected to contribute approximately 1 kcal/mol (1 cal = 4.184 J) to the free energy of folding, may provide a general strategy for substantial improvement in the stability of a protein. Study holds ProTherm entries: 1228, 1229, 1230, 1231, 1232, 1233, 13615, 13616, 13617, 13618 Extra Details: additive : EDTA(1 mM), lysozyme; protein structure; protein design; proline;,glycine

Submission Details

ID: Wk5wZgYi3

Submitter: Connie Wang

Submission Date: April 24, 2018, 8:16 p.m.

Version: 1

Publication Details
Matthews BW;Nicholson H;Becktel WJ,Proc. Natl. Acad. Sci. U.S.A. (1987) Enhanced protein thermostability from site-directed mutations that decrease the entropy of unfolding. PMID:3477797
Additional Information

Structure view and single mutant data analysis

Study data

No weblogo for data of varying length.
Colors: D E R H K S T N Q A V I L M F Y W C G P
 

Data Distribution

Studies with similar sequences (approximate matches)

Correlation with other assays (exact sequence matches)


Relevant PDB Entries

Structure ID Release Date Resolution Structure Title
2LC9 2011-08-17 Solution Structure of a Minor and Transiently Formed State of a T4 Lysozyme Mutant
5XPE 2017-10-04 Neutron structure of the T26H mutant of T4 lysozyme
2LCB 2011-08-17 Solution Structure of a Minor and Transiently Formed State of a T4 Lysozyme Mutant
2O7A 2007-04-10 0.84 T4 lysozyme C-terminal fragment
5JDT 2016-09-28 1.0 Structure of Spin-labelled T4 lysozyme mutant L118C-R1 at 100K
5XPF 2017-10-04 1.04 High-resolution X-ray structure of the T26H mutant of T4 lysozyme
6BG3 2018-09-26 1.05 Structure of (3S,4S)-1-benzyl-4-(3-(3-(trifluoromethyl)phenyl)ureido)piperidin-3-yl acetate bound to DCN1
1SX7 2004-11-30 1.06 Use of an ion-binding site to bypass the 1000-atom limit to ab initio structure determination by direct methods
1SWY 2004-11-23 1.06 Use of a Halide Binding Site to Bypass the 1000-atom Limit to Ab initio Structure Determination
1SX2 2004-11-23 1.06 Use of a Halide Binding Site to Bypass the 1000-atom Limit to Structure Determination by Direct Methods
1SWZ 2005-01-18 1.06 Use of an ion-binding site to bypass the 1000-atom limit to ab initio structure determination by direct methods
3F8V 2009-02-17 1.08 Evaulaution at Atomic Resolution of the Role of Strain in Destabilizing the Temperature Sensitive T4 Lysozyme Mutant Arg96-->His
3FA0 2009-02-17 1.09 Evaulaution at Atomic Resolution of the Role of Strain in Destabilizing the Temperature Sensitive T4 Lysozyme Mutant Arg96-->His
6BG5 2018-09-26 1.1 Structure of 1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-(1-propylpiperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)urea bound to DCN1
5LWO 2017-03-08 1.18 Structure of Spin-labelled T4 lysozyme mutant L115C-R119C-R1 at 100K
3F9L 2009-02-17 1.19 Evaulaution at Atomic Resolution of the Role of Strain in Destabilizing the Temperature Sensitive T4 Lysozyme Mutant Arg96-->His
3FAD 2009-02-17 1.2 Evaulaution at Atomic Resolution of the Role of Strain in Destabilizing the Temperature Sensitive T4 Lysozyme Mutant Arg96-->His
3HH6 2009-10-13 1.25 New azaborine compounds bind to the T4 lysozyme L99A cavity -ethylbenzene as control
3DKE 2008-11-25 1.25 Polar and non-polar cavities in phage T4 lysozyme
3HH4 2009-10-13 1.25 New azaborine compounds bind to the T4 lysozyme L99A cavity - Benzene as control
3HH3 2009-10-13 1.25 New azaborine compounds bind to the T4 lysozyme L99A cavity - 1,2-dihydro-1,2-azaborine
3HH5 2009-10-13 1.25 New azaborine compounds bind to the T4 lysozyme L99A cavity - 1-ethyl-2-hydro-1,2-azaborine
3HTG 2009-11-03 1.26 2-ethoxy-3,4-dihydro-2h-pyran in complex with T4 lysozyme L99A/M102Q
3HUK 2009-11-03 1.29 Benzylacetate in complex with T4 lysozyme L99A/M102Q
2RBN 2008-03-18 1.29 N-phenylglycinonitrile in complex with T4 lysozyme L99A/M102Q
2RBO 2008-03-18 1.29 2-nitrothiophene in complex with T4 lysozyme L99A/M102Q
5JWV 2016-09-21 1.3 T4 Lysozyme L99A/M102Q with Ethylbenzene Bound
4E97 2012-09-05 1.3 T4 Lysozyme L99A/M102H with 2-Mercaptoethanol Bound
6D9M 2019-04-10 1.35 T4-Lysozyme fusion to Geobacter GGDEF
5V7D 2018-06-20 1.35 T4 lysozyme Y18Ymbr
5V7E 2018-06-20 1.36 T4 lysozyme Y18Ymcl
5V86 2017-05-24 1.37 Structure of DCN1 bound to NAcM-OPT
4W59 2015-04-01 1.39 T4 Lysozyme L99A with n-Hexylbenzene Bound
2NTG 2007-06-12 1.4 Structure of Spin-labeled T4 Lysozyme Mutant T115R7
3RUN 2012-06-06 1.4 New strategy to analyze structures of glycopeptide antibiotic-target complexes
3HTD 2009-11-03 1.4 (Z)-Thiophene-2-carboxaldoxime in complex with T4 lysozyme L99A/M102Q
2Q9D 2007-06-26 1.4 Structure of spin-labeled T4 lysozyme mutant A41R1
2IGC 2007-06-12 1.4 Structure of Spin labeled T4 Lysozyme Mutant T115R1A
3HUA 2009-11-03 1.4 4,5,6,7-tetrahydroindole in complex with T4 lysozyme L99A/M102Q
5JWT 2016-09-21 1.41 T4 Lysozyme L99A/M102Q with Benzene Bound
2RBR 2008-03-18 1.43 2-phenoxyethanol in complex with T4 lysozyme L99A/M102Q
3SBB 2011-09-21 1.43 Disulphide-mediated Tetramer of T4 Lysozyme R76C/R80C by Synthetic Symmetrization
4W51 2015-04-01 1.45 T4 Lysozyme L99A with No Ligand Bound
2F2Q 2006-04-25 1.45 High resolution crystal strcuture of T4 lysozyme mutant L20R63/A liganded to guanidinium ion
1P36 2003-10-07 1.45 T4 LYOSZYME CORE REPACKING MUTANT I100V/TA
3HUQ 2009-11-03 1.45 Thieno[3,2-b]thiophene in complex with T4 lysozyme L99A/M102Q
1LW9 2003-05-20 1.45 Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability
3GUI 2009-08-25 1.45 T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--Apo structure
5KI1 2017-04-12 1.46 PSEUDO T4 LYSOZYME MUTANT - Y18F
3HU9 2009-11-03 1.46 Nitrosobenzene in complex with T4 lysozyme L99A/M102Q
5JGR 2017-02-15 1.46 Spin-Labeled T4 Lysozyme Construct K43V1
2RB2 2008-03-18 1.46 3-methylbenzylazide in complex with T4 lysozyme L99A
5JWW 2016-09-21 1.47 T4 Lysozyme L99A/M102Q with 1-Hydro-2-ethyl-1,2-azaborine Bound
5KGR 2017-02-15 1.47 Spin-Labeled T4 Lysozyme Construct I9V1/V131V1 (30 days)
2RBP 2008-03-18 1.47 2-(n-propylthio)ethanol in complex with T4 lysozyme L99A/M102Q
5JGU 2017-02-15 1.47 Spin-Labeled T4 Lysozyme Construct R119V1
4I7M 2013-03-27 1.48 T4 Lysozyme L99A/M102H with 2-allylphenol bound
5KHZ 2017-04-12 1.49 PSEUDO T4 LYSOZYME
4EKR 2012-09-05 1.49 T4 Lysozyme L99A/M102H with 2-Cyanophenol Bound
5KIM 2017-04-12 1.5 PSEUDO T4 LYSOZYME MUTANT - Y88PHE-I
5KI2 2017-04-12 1.5 PSEUDO T4 LYSOZYME MUTANT - Y18PHE-METHYL
3GUN 2009-08-25 1.5 T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--aniline binding
4W52 2015-04-01 1.5 T4 Lysozyme L99A with Benzene Bound
3K2R 2010-10-13 1.5 Crystal Structure of Spin Labeled T4 Lysozyme Mutant K65V1/R76V1
1P7S 2003-10-07 1.5 T4 LYSOZYME CORE REPACKING MUTANT V103I/TA
3GUP 2009-08-25 1.5 T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--pyridine binding
5KIG 2017-04-12 1.5 PSEUDO T4 LYSOZYME MUTANT - Y88F
1PQM 2003-10-07 1.52 T4 Lysozyme Core Repacking Mutant V149I/T152V/TA
4I7L 2013-04-03 1.52 T4 Lysozyme L99A/M102H with phenol bound
4I7R 2013-03-27 1.52 T4 Lysozyme L99A/M102H with 2-(pyrazolo-1-yl) ethanol bound
5JGX 2017-02-15 1.53 Spin-Labeled T4 Lysozyme Construct V131V1
3FI5 2009-02-17 1.53 Crystal Structure of T4 Lysozyme Mutant R96W
5JGN 2017-02-15 1.53 Spin-Labeled T4 Lysozyme Construct I9V1
5JGZ 2017-02-15 1.53 Spin-Labeled T4 Lysozyme Construct T151V1
4EKQ 2012-09-05 1.54 T4 Lysozyme L99A/M102H with 4-Nitrophenol Bound
1P6Y 2003-10-07 1.54 T4 LYSOZYME CORE REPACKING MUTANT M120Y/TA
1P3N 2003-10-07 1.55 CORE REDESIGN BACK-REVERTANT I103V/CORE10
1XEP 2005-05-31 1.55 Catechol in complex with T4 lysozyme L99A/M102Q
5KI8 2017-04-12 1.55 PSEUDO T4 LYSOZYME MUTANT - Y88PHE-BR
2OU9 2007-06-12 1.55 Structure of Spin-labeled T4 Lysozyme Mutant T115R1/R119A
4I7T 2013-03-27 1.55 T4 Lysozyme L99A/M102H with 2-bromo-5-hydroxybenzaldehyde bound
2RBS 2008-03-18 1.56 (r)(+)-3-chloro-1-phenyl-1-propanol in complex with T4 lysozyme L99A/M102Q
4W53 2015-04-01 1.56 T4 Lysozyme L99A with Toluene Bound
5KII 2017-04-12 1.56 PSEUDO T4 LYSOZYME MUTANT - Y88PHE-METHYL
1P37 2003-10-07 1.57 T4 LYSOZYME CORE REPACKING BACK-REVERTANT L102M/CORE10
1PQI 2003-10-07 1.57 T4 LYSOZYME CORE REPACKING MUTANT I118L/CORE7/TA
1P2R 2003-10-07 1.58 T4 LYSOZYME CORE REPACKING MUTANT I78V/TA
4I7Q 2013-03-27 1.58 T4 Lysozyme L99A/M102H with 4-trifluoromethylimidazole bound
4I7N 2013-03-27 1.58 T4 Lysozyme L99A/M102H with 1-phenyl-2-propyn-1-ol bound
1P2L 2003-10-07 1.58 T4 Lysozyme Core Repacking Mutant V87I/TA
3HT6 2009-11-03 1.59 2-methylphenol in complex with T4 lysozyme L99A/M102Q
3HT8 2009-11-03 1.6 5-chloro-2-methylphenol in complex with T4 lysozyme L99A/M102Q
1ZUR 2006-10-17 1.6 Crystal structure of spin labeled T4 Lysozyme (V131R1F)
5V88 2017-05-24 1.6 Structure of DCN1 bound to NAcM-COV
4I7P 2013-03-27 1.6 T4 Lysozyme L99A/M102H with 4-bromoimidazole bound
3GUJ 2009-08-25 1.6 T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--Benzene binding
5G27 2016-11-23 1.61 Structure of Spin-labelled T4 lysozyme mutant L118C-R1 at Room Temperature
1P64 2003-10-07 1.62 T4 LYSOZYME CORE REPACKING MUTANT L133F/TA
5KIO 2017-04-12 1.63 PSEUDO T4 LYSOZYME MUTANT - Y18PHE-I
5VNR 2017-07-26 1.63 X-ray strucutre of perdeuterated T4 lysozyme cysteine-free pseudo-wild type at cryogenic temperature
3CDT 2009-02-17 1.63 Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme
4W56 2015-04-01 1.63 T4 Lysozyme L99A with sec-Butylbenzene Bound
2RBQ 2008-03-18 1.63 3-methylbenzylazide in complex with T4 L99A/M102Q
4W55 2015-04-01 1.64 T4 Lysozyme L99A with n-Propylbenzene Bound
2RAZ 2008-03-18 1.64 4-(methylthio)nitrobenzene in complex with T4 lysozyme L99A
4EKP 2012-09-05 1.64 T4 Lysozyme L99A/M102H with Nitrobenzene Bound
4EKS 2012-09-05 1.64 T4 Lysozyme L99A/M102H with Isoxazole Bound
3C8Q 2009-02-17 1.64 Contribution of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme
1PQD 2003-10-07 1.65 T4 LYSOZYME CORE REPACKING MUTANT CORE10/TA
119L 1993-10-31 1.65 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
5V7F 2018-06-20 1.65 T4 lysozyme Y18Ymi
3DMV 2008-11-11 1.65 Free of ligand binding in the hydrophobic cavity of T4 lysozyme L99A mutant
1LPY 2002-05-22 1.65 Multiple Methionine Substitutions in T4 Lysozyme
5JWS 2016-09-21 1.65 T4 Lysozyme L99A with 1-Hydro-2-ethyl-1,2-azaborine Bound
1PQO 2003-10-07 1.65 T4 Lysozyme Core Repacking Mutant L118I/TA
1L58 1991-10-15 1.65 ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
5KI3 2017-04-12 1.65 PSEUDO T4 LYSOZYME MUTANT - Y18PHE-BR
219L 1996-12-23 1.66 PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
4I7J 2013-03-27 1.67 T4 Lysozyme L99A/M102H with benzene bound
3C7Z 2009-02-17 1.67 T4 lysozyme mutant D89A/R96H at room temperature
1P46 2003-10-07 1.67 T4 lysozyme core repacking mutant M106I/TA
3C82 2009-02-17 1.68 Bacteriophage lysozyme T4 lysozyme mutant K85A/R96H
3C8S 2009-02-17 1.68 Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme
3CDQ 2009-02-17 1.68 Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme
4W57 2015-04-01 1.68 T4 Lysozyme L99A with n-Butylbenzene Bound
4I7S 2013-03-27 1.69 T4 Lysozyme L99A/M102H with 3-trifluoromethyl-5-methyl pyrazole bound
161L 1994-08-31 1.7 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
241L 1998-03-18 1.7 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
217L 1993-10-31 1.7 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
3CDR 2009-02-17 1.7 R96Q Mutant of wildtype phage T4 lysozyme at 298 K
1L19 1990-01-15 1.7 ENHANCED PROTEIN THERMOSTABILITY FROM DESIGNED MUTATIONS THAT INTERACT WITH ALPHA-HELIX DIPOLES
1L07 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
1L52 1991-10-15 1.7 STRUCTURAL AND THERMODYNAMIC ANALYSIS OF THE PACKING OF TWO ALPHA-HELICES IN BACTERIOPHAGE T4 LYSOZYME
3HT7 2009-11-03 1.7 2-ethylphenol in complex with T4 lysozyme L99A/M102Q
1L15 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
1L12 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
1L24 1990-01-15 1.7 ENHANCED PROTEIN THERMOSTABILITY FROM SITE-DIRECTED MUTATIONS THAT DECREASE THE ENTROPY OF UNFOLDING
1L05 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
128L 1993-10-31 1.7 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
1L36 1991-10-15 1.7 TOWARD A SIMPLIFICATION OF THE PROTEIN FOLDING PROBLEM: A STABILIZING POLYALANINE ALPHA-HELIX ENGINEERED IN T4 LYSOZYME
1L68 1991-10-15 1.7 TOLERANCE OF T4 LYSOZYME TO MULTIPLE XAA (RIGHT ARROW) ALA SUBSTITUTIONS: A POLYALANINE ALPHA-HELIX CONTAINING TEN CONSECUTIVE ALANINES
3DNA 2008-11-11 1.7 Iodobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant (seleno version)
1L11 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
237L 1998-03-18 1.7 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
244L 1998-03-18 1.7 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
2LZM 1986-10-24 1.7 STRUCTURE OF BACTERIOPHAGE T4 LYSOZYME REFINED AT 1.7 ANGSTROMS RESOLUTION
1LWG 2003-05-20 1.7 Multiple Methionine Substitutions are Tolerated in T4 Lysozyme and have Coupled Effects on Folding and Stability
1L06 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
1L08 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
1L02 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
1L23 1990-01-15 1.7 ENHANCED PROTEIN THERMOSTABILITY FROM SITE-DIRECTED MUTATIONS THAT DECREASE THE ENTROPY OF UNFOLDING
1L32 1990-01-15 1.7 REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY
1L46 1991-10-15 1.7 CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY
1L22 1990-01-15 1.7 CONTRIBUTIONS OF LEFT-HANDED HELICAL RESIDUES TO THE STRUCTURE AND STABILITY OF BACTERIOPHAGE T4 LYSOZYME
1L14 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
3LZM 1990-01-15 1.7 STRUCTURAL STUDIES OF MUTANTS OF T4 LYSOZYME THAT ALTER HYDROPHOBIC STABILIZATION
1L45 1991-10-15 1.7 CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY
139L 1994-01-31 1.7 RAPID CRYSTALLIZATION OF T4 LYSOZYME BY INTERMOLECULAR DISULFIDE CROSSLINKING
1L44 1991-10-15 1.7 CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY
211L 1996-12-23 1.7 PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
1L62 1991-10-15 1.7 ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
1L13 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
1L10 1988-04-16 1.7 STRUCTURAL STUDIES OF MUTANTS OF THE LYSOZYME OF BACTERIOPHAGE T4. THE TEMPERATURE-SENSITIVE MUTANT PROTEIN THR157 (RIGHT ARROW) ILE
1L04 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
1L17 1990-01-15 1.7 HYDROPHOBIC STABILIZATION IN T4 LYSOZYME DETERMINED DIRECTLY BY MULTIPLE SUBSTITUTIONS OF ILE 3
131L 1994-01-31 1.7 STRUCTURES OF RANDOMLY GENERATED MUTANTS OF T4 LYSOZYME SHOW THAT PROTEIN STABILITY CAN BE ENHANCED BY RELAXATION OF STRAIN AND BY IMPROVED HYDROGEN BONDING VIA BOUND SOLVENT
1LYH 1993-10-31 1.7 DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO ACID SUBSTITUTIONS AT THR 59
1L18 1990-01-15 1.7 HYDROPHOBIC STABILIZATION IN T4 LYSOZYME DETERMINED DIRECTLY BY MULTIPLE SUBSTITUTIONS OF ILE 3
1L48 1991-10-15 1.7 STRUCTURAL AND THERMODYNAMIC ANALYSIS OF THE PACKING OF TWO ALPHA-HELICES IN BACTERIOPHAGE T4 LYSOZYME
1L60 1991-10-15 1.7 ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
130L 1994-01-31 1.7 STRUCTURES OF RANDOMLY GENERATED MUTANTS OF T4 LYSOZYME SHOW THAT PROTEIN STABILITY CAN BE ENHANCED BY RELAXATION OF STRAIN AND BY IMPROVED HYDROGEN BONDING VIA BOUND SOLVENT
1L29 1990-01-15 1.7 REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY
1ZYT 2006-08-15 1.7 Crystal structure of spin labeled T4 Lysozyme (A82R1)
1L33 1990-01-15 1.7 CONTRIBUTIONS OF LEFT-HANDED HELICAL RESIDUES TO THE STRUCTURE AND STABILITY OF BACTERIOPHAGE T4 LYSOZYME
129L 1994-01-31 1.7 STRUCTURES OF RANDOMLY GENERATED MUTANTS OF T4 LYSOZYME SHOW THAT PROTEIN STABILITY CAN BE ENHANCED BY RELAXATION OF STRAIN AND BY IMPROVED HYDROGEN BONDING VIA BOUND SOLVENT
1L09 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
1L30 1990-01-15 1.7 REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY
1KNI 2001-12-28 1.7 Stabilizing Disulfide Bridge Mutant of T4 Lysozyme
1L92 1993-10-31 1.7 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
5JWU 2016-09-21 1.7 T4 Lysozyme L99A/M102Q with 1,2-Dihydro-1,2-azaborine Bound
138L 1994-01-31 1.7 RAPID CRYSTALLIZATION OF T4 LYSOZYME BY INTERMOLECULAR DISULFIDE CROSSLINKING
1G07 2001-05-23 1.7 CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT V149C
221L 1994-01-31 1.7 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
1L47 1991-10-15 1.7 CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY
1L03 1988-04-16 1.7 CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME
173L 1995-07-10 1.7 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
1L66 1991-10-15 1.7 TOLERANCE OF T4 LYSOZYME TO MULTIPLE XAA (RIGHT ARROW) ALA SUBSTITUTIONS: A POLYALANINE ALPHA-HELIX CONTAINING TEN CONSECUTIVE ALANINES
1G0M 2001-05-23 1.7 CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT T152I
1L65 1991-10-15 1.7 TOLERANCE OF T4 LYSOZYME TO MULTIPLE XAA (RIGHT ARROW) ALA SUBSTITUTIONS: A POLYALANINE ALPHA-HELIX CONTAINING TEN CONSECUTIVE ALANINES
4LZM 1992-07-15 1.7 COMPARISON OF THE CRYSTAL STRUCTURE OF BACTERIOPHAGE T4 LYSOZYME AT LOW, MEDIUM, AND HIGH IONIC STRENGTHS
2RB1 2008-06-03 1.7 2-ethoxyphenol in complex with T4 lysozyme L99A
1L16 1988-04-16 1.7 STRUCTURAL ANALYSIS OF THE TEMPERATURE-SENSITIVE MUTANT OF BACTERIOPHAGE T4 LYSOZYME, GLYCINE 156 (RIGHT ARROW) ASPARTIC ACID
2A4T 2006-06-13 1.7 Crystal structure of spin labeled T4 Lysozyme (V131R7)
1L83 1993-10-31 1.7 A CAVITY-CONTAINING MUTANT OF T4 LYSOZYME IS STABILIZED BY BURIED BENZENE
3DN8 2008-11-11 1.7 Iodopentafluorobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant (seleno version)
2F47 2006-04-25 1.7 Xray crystal structure of T4 lysozyme mutant L20/R63A liganded to methylguanidinium
1L26 1990-01-15 1.7 REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY
1L74 1991-10-15 1.7 MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
110L 1993-10-31 1.7 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
1L01 1988-04-16 1.7 STRUCTURAL STUDIES OF MUTANTS OF THE LYSOZYME OF BACTERIOPHAGE T4. THE TEMPERATURE-SENSITIVE MUTANT PROTEIN THR157 (RIGHT ARROW) ILE
4I7K 2013-03-27 1.72 T4 Lysozyme L99A/M102H with toluene bound
5JGV 2017-02-15 1.73 Spin-Labeled T4 Lysozyme Construct A73V1
3CDV 2009-02-17 1.73 Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme
232L 1998-01-14 1.73 T4 LYSOZYME MUTANT M120K
4I7O 2013-03-27 1.73 T4 Lysozyme L99A/M102H with 2-amino-5-chlorothiazole bound
4EPI 2012-06-20 1.74 The crystal structure of pesticin-T4 lysozyme hybrid stabilized by engineered disulfide bonds
102L 1993-10-31 1.74 HOW AMINO-ACID INSERTIONS ARE ALLOWED IN AN ALPHA-HELIX OF T4 LYSOZYME
1L41 1991-10-15 1.75 CONTRIBUTIONS OF ENGINEERED SURFACE SALT BRIDGES TO THE STABILITY OF T4 LYSOZYME DETERMINED BY DIRECTED MUTAGENESIS
1L90 1993-10-31 1.75 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
166L 1994-08-31 1.75 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
1DYB 1993-10-31 1.75 DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME
2CUU 2006-08-15 1.75 Crystal structure of spin labeled T4 Lysozyme (V131R1)
1KW5 2003-06-03 1.75 METHIONINE CORE MUTANT OF T4 LYSOZYME
247L 1998-03-18 1.75 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
1L63 1991-10-15 1.75 ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
5I14 2016-02-17 1.75 Truncated and mutated T4 lysozyme
180L 1996-04-03 1.75 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
1L59 1991-10-15 1.75 ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
206L 1996-08-17 1.75 PHAGE T4 LYSOZYME
1QUD 1999-07-08 1.75 L99G MUTANT OF T4 LYSOZYME
165L 1994-08-31 1.75 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
240L 1998-03-18 1.75 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
243L 1998-03-18 1.75 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
212L 1996-12-23 1.76 PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
3C7W 2009-02-17 1.77 Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme
6FW2 2018-10-31 1.78 Crystal Structure of human mARC1
4W54 2015-04-01 1.79 T4 Lysozyme L99A with Ethylbenzene Bound
160L 1994-08-31 1.8 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
107L 1993-10-31 1.8 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
3C8R 2009-02-17 1.8 Contributions of all 20 amino acids at site 96 to stability and structure of T4 lysozyme
256L 1998-05-27 1.8 BACTERIOPHAGE T4 LYSOZYME
183L 1995-07-10 1.8 SPECIFICITY OF LIGAND BINDING IN A BURIED NON-POLAR CAVITY OF T4 LYSOZYME: LINKAGE OF DYNAMICS AND STRUCTURAL PLASTICITY
2NTH 2007-06-12 1.8 Structure of Spin-labeled T4 Lysozyme Mutant L118R1
245L 1998-03-18 1.8 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
1LYE 1993-10-31 1.8 DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO ACID SUBSTITUTIONS AT THR 59
1LYF 1993-10-31 1.8 DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO ACID SUBSTITUTIONS AT THR 59
2OU8 2007-06-12 1.8 Structure of Spin-labeled T4 Lysozyme Mutant T115R1 at Room Temperature
6LZM 1992-07-15 1.8 COMPARISON OF THE CRYSTAL STRUCTURE OF BACTERIOPHAGE T4 LYSOZYME AT LOW, MEDIUM, AND HIGH IONIC STRENGTHS
3HWL 2009-12-08 1.8 Crystal Structure of T4 lysozyme with the unnatural amino acid p-Acetyl-L-Phenylalanine incorporated at position 131
111L 1993-10-31 1.8 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
3DN3 2008-11-11 1.8 Iodopentafluorobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant
3DN1 2008-11-11 1.8 Chloropentafluorobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant
185L 1995-07-10 1.8 SPECIFICITY OF LIGAND BINDING IN A BURIED NON-POLAR CAVITY OF T4 LYSOZYME: LINKAGE OF DYNAMICS AND STRUCTURAL PLASTICITY
1L42 1991-10-15 1.8 CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY
118L 1993-10-31 1.8 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
1LLH 2002-05-15 1.8 ARE CARBOXY TERMINII OF HELICES CODED BY THE LOCAL SEQUENCE OR BY TERTIARY STRUCTURE CONTACTS
3G3X 2009-05-05 1.8 Crystal structure of spin labeled T4 Lysozyme (T151R1) at 100 K
108L 1993-10-31 1.8 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
1L61 1991-10-15 1.8 ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
226L 1998-03-18 1.8 GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS
260L 2000-09-11 1.8 AN ADAPTABLE METAL-BINDING SITE ENGINEERED INTO T4 LYSOZYME
1P56 2004-05-04 1.8 Duplication-extension of Helix A of T4 lysozyme
1G1W 2001-05-09 1.8 T4 LYSOZYME MUTANT C54T/C97A/Q105M
1QT7 1999-07-08 1.8 E11N Mutant of T4 Lysozyme
122L 1993-10-31 1.8 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
238L 1998-03-18 1.8 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
1QSB 1999-07-07 1.8 THE INTRODUCTION OF STRAIN AND ITS EFFECTS ON THE STRUCTURE AND STABILITY OF T4 LYSOZYME
1G0Q 2001-05-23 1.8 CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT V149I
250L 1998-03-18 1.8 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
2RAY 2008-03-18 1.8 beta-chlorophenetole in complex with T4 lysozyme L99A
126L 1993-10-31 1.8 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
158L 1994-08-31 1.8 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
1G0P 2001-05-23 1.8 CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT V149G
1L38 1991-10-15 1.8 CONTRIBUTIONS OF ENGINEERED SURFACE SALT BRIDGES TO THE STABILITY OF T4 LYSOZYME DETERMINED BY DIRECTED MUTAGENESIS
3DN4 2008-11-11 1.8 Iodobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant
162L 1994-08-31 1.8 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
1CVK 1999-11-10 1.8 T4 LYSOZYME MUTANT L118A
4W58 2015-04-01 1.8 T4 Lysozyme L99A with n-Pentylbenzene Bound
114L 1993-10-31 1.8 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
163L 1994-08-31 1.8 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
1L86 1993-10-31 1.8 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
1L25 1990-01-15 1.8 REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY
1G0L 2001-05-23 1.8 CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT T152V
159L 1994-08-31 1.8 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
188L 1995-07-10 1.8 SPECIFICITY OF LIGAND BINDING IN A BURIED NON-POLAR CAVITY OF T4 LYSOZYME: LINKAGE OF DYNAMICS AND STRUCTURAL PLASTICITY
1L94 1993-10-31 1.8 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
2O79 2007-04-10 1.8 T4 lysozyme with C-terminal extension
1T8G 2004-10-19 1.8 Crystal structure of phage T4 lysozyme mutant L32A/L33A/T34A/C54T/C97A/E108V
120L 1993-10-31 1.8 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
1L27 1990-01-15 1.8 REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY
1CV3 1999-08-24 1.8 T4 LYSOZYME MUTANT L121M
1L56 1991-10-15 1.8 ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
2HUL 2006-10-17 1.8 Crystal structure of T4 Lysozyme S44C synthetic dimer
187L 1995-07-10 1.8 SPECIFICITY OF LIGAND BINDING IN A BURIED NON-POLAR CAVITY OF T4 LYSOZYME: LINKAGE OF DYNAMICS AND STRUCTURAL PLASTICITY
1L91 1993-10-31 1.8 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
239L 1998-03-18 1.8 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
3HU8 2009-11-03 1.8 2-ethoxyphenol in complex with T4 lysozyme L99A/M102Q
164L 1994-08-31 1.8 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
115L 1993-10-31 1.8 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
182L 1995-07-10 1.8 SPECIFICITY OF LIGAND BINDING IN A BURIED NON-POLAR CAVITY OF T4 LYSOZYME: LINKAGE OF DYNAMICS AND STRUCTURAL PLASTICITY
1L98 1993-10-31 1.8 PERTURBATION OF TRP 138 IN T4 LYSOZYME BY MUTATIONS AT GLN 105 USED TO CORRELATE CHANGES IN STRUCTURE, STABILITY, SOLVATION, AND SPECTROSCOPIC PROPERTIES
2F32 2006-04-25 1.8 Xray crystal structure of lysozyme mutant L20/R63A liganded to ethylguanidinium
7LZM 1992-07-15 1.8 COMPARISON OF THE CRYSTAL STRUCTURE OF BACTERIOPHAGE T4 LYSOZYME AT LOW, MEDIUM, AND HIGH IONIC STRENGTHS
1L31 1990-01-15 1.8 REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY
1L93 1993-10-31 1.8 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
258L 2000-09-11 1.8 AN ADAPTABLE METAL-BINDING SITE ENGINEERED INTO T4 LYSOZYME
184L 1995-07-10 1.8 SPECIFICITY OF LIGAND BINDING IN A BURIED NON-POLAR CAVITY OF T4 LYSOZYME: LINKAGE OF DYNAMICS AND STRUCTURAL PLASTICITY
229L 1998-03-18 1.8 GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS
1DYE 1993-10-31 1.8 DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME
1L87 1993-10-31 1.8 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
113L 1993-10-31 1.8 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
1L80 1993-04-15 1.8 DESIGN AND STRUCTURAL ANALYSIS OF ALTERNATIVE HYDROPHOBIC CORE PACKING ARRANGEMENTS IN BACTERIOPHAGE T4 LYSOZYME
5LZM 1992-07-15 1.8 COMPARISON OF THE CRYSTAL STRUCTURE OF BACTERIOPHAGE T4 LYSOZYME AT LOW, MEDIUM, AND HIGH IONIC STRENGTHS
1QT5 1999-07-08 1.8 D20E MUTANT STRUCTURE OF T4 LYSOZYME
1G0J 2001-05-23 1.8 CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT T152S
3DN0 2008-11-11 1.8 Pentafluorobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant
1L43 1991-10-15 1.8 CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY
1ZWN 2006-10-17 1.8 Crystal structure of spin labeled T4 Lysozyme (V131R1B)
1NHB 1995-07-10 1.8 Specificity of ligand binding in a buried non-polar cavity of t4 lysozyme: linkage of dynamics and structural plasticity
156L 1994-08-31 1.8 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
1LYJ 1993-10-31 1.8 DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO ACID SUBSTITUTIONS AT THR 59
1C69 2000-10-04 1.8 T4 LYSOZYME MUTANT C54T/C97A/L133A IN THE PRESENCE OF 8 ATM ARGON
112L 1993-10-31 1.8 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
242L 1998-03-18 1.8 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
3DMX 2009-01-27 1.8 Benzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant
123L 1993-10-31 1.8 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
3L2X 2011-01-05 1.8 Crystal Structure of Spin Labeled T4 Lysozyme Mutant 115-119RX
246L 1998-03-18 1.8 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
186L 1995-07-10 1.8 SPECIFICITY OF LIGAND BINDING IN A BURIED NON-POLAR CAVITY OF T4 LYSOZYME: LINKAGE OF DYNAMICS AND STRUCTURAL PLASTICITY
3DN6 2008-11-11 1.8 1,3,5-trifluoro-2,4,6-trichlorobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant
3DN2 2008-11-11 1.8 Bromopentafluorobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant
1L49 1991-10-15 1.8 STRUCTURAL AND THERMODYNAMIC ANALYSIS OF THE PACKING OF TWO ALPHA-HELICES IN BACTERIOPHAGE T4 LYSOZYME
181L 1995-07-10 1.8 SPECIFICITY OF LIGAND BINDING IN A BURIED NON-POLAR CAVITY OF T4 LYSOZYME: LINKAGE OF DYNAMICS AND STRUCTURAL PLASTICITY
1LYG 1993-10-31 1.8 DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO ACID SUBSTITUTIONS AT THR 59
1L35 1990-01-15 1.8 STRUCTURE OF A THERMOSTABLE DISULFIDE-BRIDGE MUTANT OF PHAGE T4 LYSOZYME SHOWS THAT AN ENGINEERED CROSSLINK IN A FLEXIBLE REGION DOES NOT INCREASE THE RIGIDITY OF THE FOLDED PROTEIN
255L 1998-01-28 1.8 HYDROLASE
3HTB 2009-11-03 1.81 2-propylphenol in complex with T4 lysozyme L99A/M102Q
2OTY 2007-08-07 1.83 1,2-dichlorobenzene in complex with T4 Lysozyme L99A
3C83 2009-02-17 1.84 Bacteriophage T4 lysozyme mutant D89A in wildtype background at room temperature
2RB0 2008-03-18 1.84 2,6-difluorobenzylbromide complex with T4 lysozyme L99A
1L50 1991-10-15 1.85 STRUCTURAL AND THERMODYNAMIC ANALYSIS OF THE PACKING OF TWO ALPHA-HELICES IN BACTERIOPHAGE T4 LYSOZYME
1QUH 1999-07-08 1.85 L99G/E108V MUTANT OF T4 LYSOZYME
125L 1993-10-31 1.85 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
1G0K 2001-05-23 1.85 CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT T152C
224L 1994-01-31 1.85 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
3GUK 2009-08-25 1.85 T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--Toluene binding
1L53 1991-10-15 1.85 STRUCTURAL AND THERMODYNAMIC ANALYSIS OF THE PACKING OF TWO ALPHA-HELICES IN BACTERIOPHAGE T4 LYSOZYME
1L73 1991-10-15 1.85 MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
1L20 1990-01-15 1.85 ENHANCED PROTEIN THERMOSTABILITY FROM DESIGNED MUTATIONS THAT INTERACT WITH ALPHA-HELIX DIPOLES
1L40 1991-10-15 1.85 CONTRIBUTIONS OF ENGINEERED SURFACE SALT BRIDGES TO THE STABILITY OF T4 LYSOZYME DETERMINED BY DIRECTED MUTAGENESIS
127L 1993-10-31 1.85 THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
155L 1994-08-31 1.85 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
1LI3 2002-05-08 1.85 T4 lysozyme mutant L99A/M102Q bound by 3-chlorophenol
1L21 1990-01-15 1.85 CONTRIBUTIONS OF LEFT-HANDED HELICAL RESIDUES TO THE STRUCTURE AND STABILITY OF BACTERIOPHAGE T4 LYSOZYME
1EPY 2000-04-12 1.85 T4 LYSOZYME MUTANT, T21H/C54T/C97A/Q141H/T142H
1L88 1993-10-31 1.85 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
1L72 1991-10-15 1.85 MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
1L37 1991-10-15 1.85 CONTRIBUTIONS OF ENGINEERED SURFACE SALT BRIDGES TO THE STABILITY OF T4 LYSOZYME DETERMINED BY DIRECTED MUTAGENESIS
137L 1994-07-31 1.85 STRUCTURAL BASIS OF AMINO ACID ALPHA HELIX PROPENSITY
3HTF 2009-11-03 1.85 4-chloro-1h-pyrazole in complex with T4 lysozyme L99A/M102Q
1G06 2001-05-23 1.85 CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT V149S
220L 1998-03-18 1.85 GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS
3C81 2009-02-17 1.85 Mutant K85A of T4 lysozyme in wildtype background at room temperature
109L 1993-10-31 1.85 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
146L 1994-01-31 1.85 ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4 LYSOZYME
199L 1996-03-08 1.85 THERMODYNAMIC AND STRUCTURAL COMPENSATION IN 'SIZE-SWITCH' CORE-REPACKING VARIANTS OF T4 LYSOZYME
1L39 1991-10-15 1.85 CONTRIBUTIONS OF ENGINEERED SURFACE SALT BRIDGES TO THE STABILITY OF T4 LYSOZYME DETERMINED BY DIRECTED MUTAGENESIS
1QS9 1999-07-02 1.85 THE INTRODUCTION OF STRAIN AND ITS EFFECTS ON THE STRUCTURE AND STABILITY OF T4 LYSOZYME
1QT3 1999-07-08 1.85 T26D MUTANT OF T4 LYSOZYME
157L 1994-08-31 1.85 CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND
1CU2 1999-11-10 1.85 T4 LYSOZYME MUTANT L84M
1LGW 2002-05-08 1.85 T4 Lysozyme Mutant L99A/M102Q Bound by 2-fluoroaniline
1L71 1991-10-15 1.85 MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
3CDO 2009-02-17 1.87 Bacteriophage T4 lysozyme mutant R96V in wildtype background at low temperature
1CV5 1999-11-10 1.87 T4 LYSOZYME MUTANT L133M
214L 1996-12-23 1.89 PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
1KW7 2003-06-03 1.89 METHIONINE CORE MUTANT OF T4 LYSOZYME
210L 1996-12-23 1.89 PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
1D2W 1999-10-08 1.89 N-TERMINAL DOMAIN CORE METHIONINE MUTATION
1CUP 1999-11-10 1.89 METHIONINE CORE MUTANT OF T4 LYSOZYME
249L 1998-03-18 1.9 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
1L54 1991-10-15 1.9 THE STRUCTURAL AND THERMODYNAMIC CONSEQUENCES OF BURYING A CHARGED RESIDUE WITHIN THE HYDROPHOBIC CORE OF T4 LYSOZYME
148L 1994-04-30 1.9 A COVALENT ENZYME-SUBSTRATE INTERMEDIATE WITH SACCHARIDE DISTORTION IN A MUTANT T4 LYSOZYME
1QUO 1999-07-08 1.9 L99A/E108V MUTANT OF T4 LYSOZYME
223L 1998-03-18 1.9 GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS
1QT8 1999-07-08 1.9 T26H Mutant of T4 Lysozyme
1JTM 2002-03-20 1.9 Alternative Structures of a Sequence Extended T4 Lysozyme Show that the Highly Conserved Beta-Sheet has Weak Intrinsic Folding Propensity
1QSQ 1999-06-29 1.9 CAVITY CREATING MUTATION
1L76 1991-10-15 1.9 TOLERANCE OF T4 LYSOZYME TO PROLINE SUBSTITUTIONS WITHIN THE LONG INTERDOMAIN ALPHA-HELIX ILLUSTRATES THE ADAPTABILITY OF PROTEINS TO POTENTIALLY DESTABILIZING LESIONS
1QUG 1999-07-08 1.9 E108V MUTANT OF T4 LYSOZYME
3L64 2010-01-19 1.9 T4 Lysozyme S44E/WT*
1C6E 2000-10-04 1.9 T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 2 ATM XENON
1OWY 2004-04-13 1.9 T4 Lysozyme Cavity Mutant L99A/M102Q Bound With 2-Propyl-Aniline
103L 1993-10-31 1.9 HOW AMINO-ACID INSERTIONS ARE ALLOWED IN AN ALPHA-HELIX OF T4 LYSOZYME
1CV6 1999-11-10 1.9 T4 LYSOZYME MUTANT V149M
1DYF 1993-10-31 1.9 DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME
1L51 1991-10-15 1.9 STRUCTURAL AND THERMODYNAMIC ANALYSIS OF THE PACKING OF TWO ALPHA-HELICES IN BACTERIOPHAGE T4 LYSOZYME
225L 1998-03-18 1.9 GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS
1C6K 2000-10-04 1.9 T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 8 ATM XENON
257L 2000-09-11 1.9 AN ADAPTABLE METAL-BINDING SITE ENGINEERED INTO T4 LYSOZYME
1L57 1991-10-15 1.9 ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
1L64 1991-10-15 1.9 TOLERANCE OF T4 LYSOZYME TO MULTIPLE XAA (RIGHT ARROW) ALA SUBSTITUTIONS: A POLYALANINE ALPHA-HELIX CONTAINING TEN CONSECUTIVE ALANINES
1L84 1993-10-31 1.9 A CAVITY-CONTAINING MUTANT OF T4 LYSOZYME IS STABILIZED BY BURIED BENZENE
1C6H 2000-10-04 1.9 T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 4 ATM XENON
1QTH 1999-07-22 1.9 THE INTRODUCTION OF STRAIN AND ITS EFFECTS ON THE STRUCTURE AND STABILITY OF T4 LYSOZYME
1L70 1991-10-15 1.9 MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
1C6L 2000-10-04 1.9 T4 LYSOZYME MUTANT C54T/C97A/L99A/F153A IN THE PRESENCE OF 8 ATM ARGON
1QT6 1999-07-08 1.9 E11H Mutant of T4 Lysozyme
228L 1998-03-18 1.9 GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS
1DYA 1993-10-31 1.9 DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME
230L 1998-01-14 1.9 T4 LYSOZYME MUTANT M6L
248L 1998-03-18 1.9 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
1B6I 2000-01-12 1.9 T4 LYSOZYME MUTANT WITH CYS 54 REPLACED BY THR, CYS 97 REPLACED BY ALA, THR 21 REPLACED BY CYS AND LYS 124 REPLACED BY CYS (C54T,C97A,T21C,K124C)
1CV4 1999-11-10 1.9 T4 LYSOZYME MUTANT L118M
1LGU 2002-05-08 1.9 T4 Lysozyme Mutant L99A/M102Q
1C6P 2000-10-04 1.9 T4 LYSOZYME MUTANT C54T/C97A IN THE PRESENCE OF 8 ATM ARGON
1OWZ 2004-04-13 1.9 T4 Lysozyme Cavity Mutant L99A/M102Q Bound With 4-FluoroPhenEthyl Alcohol
1L34 1990-01-15 1.9 HIGH-RESOLUTION STRUCTURE OF THE TEMPERATURE-SENSITIVE MUTANT OF PHAGE LYSOZYME, ARG 96 (RIGHT ARROW) HIS
1L69 1991-10-15 1.9 MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
1QTB 1999-07-02 1.9 THE INTRODUCTION OF STRAIN AND ITS EFFECTS ON THE STRUCTURE AND STABILITY OF T4 LYSOZYME
236L 1998-03-18 1.9 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
192L 1995-09-15 1.9 A HELIX INITIATION SIGNAL IN T4 LYSOZYME IDENTIFIED BY POLYALANINE MUTAGENESIS
1L55 1991-10-15 1.9 ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
1LGX 2002-05-08 1.9 T4 Lysozyme Mutant L99A/M102Q Bound by 3,5-difluoroaniline
1C6I 2000-10-04 1.9 T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 8 ATM ARGON
1I6S 2001-05-09 1.9 T4 LYSOZYME MUTANT C54T/C97A/N101A
234L 1998-01-14 1.9 T4 LYSOZYME MUTANT M106L
1L00 1993-10-31 1.9 PERTURBATION OF TRP 138 IN T4 LYSOZYME BY MUTATIONS AT GLN 105 USED TO CORRELATE CHANGES IN STRUCTURE, STABILITY, SOLVATION, AND SPECTROSCOPIC PROPERTIES
1L79 1993-04-15 1.9 DESIGN AND STRUCTURAL ANALYSIS OF ALTERNATIVE HYDROPHOBIC CORE PACKING ARRANGEMENTS IN BACTERIOPHAGE T4 LYSOZYME
2O4W 2007-04-10 1.9 T4 lysozyme circular permutant
195L 1996-03-08 1.9 THERMODYNAMIC AND STRUCTURAL COMPENSATION IN 'SIZE-SWITCH' CORE-REPACKING VARIANTS OF T4 LYSOZYME
222L 1998-03-18 1.9 GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS
1C6J 2000-10-04 1.9 T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 8 ATM KRYPTON
1L28 1990-01-15 1.9 REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY
4WTV 2015-07-15 1.9 Crystal structure of the phosphatidylinositol 4-kinase IIbeta
233L 1998-01-14 1.9 T4 LYSOZYME MUTANT M120L
254L 1998-01-28 1.9 LYSOZYME
1L75 1991-10-15 1.9 MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
235L 1998-03-18 1.9 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
172L 1995-07-10 1.9 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
1G0G 2001-05-23 1.9 CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT T152A
1PQJ 2003-10-07 1.9 T4 LYSOZYME CORE REPACKING MUTANT A111V/CORE10/TA
1L89 1993-10-31 1.9 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
1C6G 2000-10-04 1.9 T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 4 ATM KRYPTON
1G1V 2001-05-09 1.9 T4 LYSOZYME MUTANT C54T/C97A/I58T
1C6Q 2000-10-04 1.9 T4 LYSOZYME MUTANT C54T/C97A IN THE PRESENCE OF 8 ATM KRYPTON
1L67 1991-10-15 1.9 TOLERANCE OF T4 LYSOZYME TO MULTIPLE XAA (RIGHT ARROW) ALA SUBSTITUTIONS: A POLYALANINE ALPHA-HELIX CONTAINING TEN CONSECUTIVE ALANINES
1D9W 1999-11-17 1.91 BACTERIOPHAGE T4 LYSOZYME MUTANT
259L 1999-04-12 1.92 AN ADAPTABLE METAL-BINDING SITE ENGINEERED INTO T4 LYSOZYME
1CX7 1999-11-10 1.94 T4 LYSOZYME METHIONINE CORE MUTANT
2OU0 2007-08-07 1.94 1-methylpyrrole in complex with T4 Lysozyme L99A
1OVH 2004-04-06 1.95 T4 Lysozyme Cavity Mutant L99A/M102Q Bound With 2-Chloro-6-Methyl-Aniline
1L99 1993-10-31 1.95 PERTURBATION OF TRP 138 IN T4 LYSOZYME BY MUTATIONS AT GLN 105 USED TO CORRELATE CHANGES IN STRUCTURE, STABILITY, SOLVATION, AND SPECTROSCOPIC PROPERTIES
3C7Y 2009-02-17 1.95 Mutant R96A OF T4 lysozyme in wildtype background at 298K
200L 1996-03-08 1.95 THERMODYNAMIC AND STRUCTURAL COMPENSATION IN 'SIZE-SWITCH' CORE-REPACKING VARIANTS OF T4 LYSOZYME
191L 1995-09-15 1.95 A HELIX INITIATION SIGNAL IN T4 LYSOZYME IDENTIFIED BY POLYALANINE MUTAGENESIS
215L 1996-12-23 1.96 PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
6IIH 2019-08-14 1.96 crystal structure of mitochondrial calcium uptake 2(MICU2)
1D3J 1999-10-08 1.97 N-TERMINAL DOMAIN CORE METHIONINE MUTATION
1KY0 2003-06-03 1.97 METHIONINE CORE MUTANT OF T4 LYSOZYME
1L0J 2003-06-03 1.98 METHIONINE CORE MUTANT OF T4 LYSOZYME
3C80 2009-02-17 1.99 T4 Lysozyme mutant R96Y at room temperature
1T8A 2004-08-17 2.0 USE OF SEQUENCE DUPLICATION TO ENGINEER A LIGAND-TRIGGERED LONG-DISTANCE MOLECULAR SWITCH IN T4 Lysozyme
142L 1994-01-31 2.0 ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4 LYSOZYME
1L97 1993-10-31 2.0 STRUCTURE OF A HINGE-BENDING BACTERIOPHAGE T4 LYSOZYME MUTANT, ILE3-> PRO
1LYD 1990-04-15 2.0 CRYSTAL STRUCTURE OF T4-LYSOZYME GENERATED FROM SYNTHETIC CODING DNA EXPRESSED IN ESCHERICHIA COLI
141L 1994-01-31 2.0 ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4 LYSOZYME
1C63 2000-10-04 2.0 T4 LYSOZYME MUTANT C54T/C97A/L121A IN THE PRESENCE OF 8 ATM ARGON
1LI2 2002-05-08 2.0 T4 Lysozyme Mutant L99A/M102Q Bound by Phenol
143L 1994-01-31 2.0 ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4 LYSOZYME
1OVJ 2004-04-06 2.0 T4 Lysozyme Cavity Mutant L99A/M102Q Bound with 3-Fluoro-2-Methyl_Aniline
1C61 2000-10-04 2.0 T4 LYSOZYME MUTANT C54T/C97A/F153A IN THE PRESENCE OF 8 ATM KRYPTON
2HUK 2006-10-17 2.0 Crystal structure of T4 Lysozyme V131C synthetic dimer
1QTZ 1999-07-08 2.0 D20C MUTANT OF T4 LYSOZYME
145L 1994-01-31 2.0 ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4 LYSOZYME
1C6C 2000-10-04 2.0 T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 16 ATM ARGON
1C6D 2000-10-04 2.0 T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 16 ATM KRYPTON
1C6T 2000-10-04 2.0 T4 LYSOZYME MUTANT C54T/C97A IN THE PRESENCE OF 8 ATM XENON
3DMZ 2008-11-11 2.0 Hexafluorobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant
1D3N 1999-09-30 2.0 METHIONINE CORE MUTATION
253L 1998-01-28 2.0 LYSOZYME
190L 1995-09-15 2.0 A HELIX INITIATION SIGNAL IN T4 LYSOZYME IDENTIFIED BY POLYALANINE MUTAGENESIS
2L78 1993-04-15 2.0 DESIGN AND STRUCTURAL ANALYSIS OF ALTERNATIVE HYDROPHOBIC CORE PACKING ARRANGEMENTS IN BACTERIOPHAGE T4 LYSOZYME
1LYI 1993-10-31 2.0 DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO ACID SUBSTITUTIONS AT THR 59
1C6F 2000-10-04 2.0 T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 32 ATM ARGON
1OV7 2004-04-06 2.0 T4 Lysozyme Cavity Mutant L99A/M102Q Bound with 2-Allyl-6-Methyl-Phenol
1TLA 1993-07-15 2.0 HYDROPHOBIC CORE REPACKING AND AROMATIC-AROMATIC INTERACTION IN THE THERMOSTABLE MUTANT OF T4 LYSOZYME SER 117 (RIGHT ARROW) PHE
152L 1994-05-31 2.0 CONSERVATION OF SOLVENT-BINDING SITES IN 10 CRYSTAL FORMS OF T4 LYSOZYME
1C60 2000-10-04 2.0 T4 LYSOZYME MUTANT C54T/C97A/F153A IN THE PRESENCE OF 8 ATM ARGON
1LI6 2002-05-08 2.0 T4 lysozyme mutant L99A/M102Q bound by 5-methylpyrrole
1L95 1993-10-31 2.0 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
1L81 1993-04-15 2.0 DESIGN AND STRUCTURAL ANALYSIS OF ALTERNATIVE HYDROPHOBIC CORE PACKING ARRANGEMENTS IN BACTERIOPHAGE T4 LYSOZYME
1L96 1993-10-31 2.0 STRUCTURE OF A HINGE-BENDING BACTERIOPHAGE T4 LYSOZYME MUTANT, ILE3-> PRO
201L 1994-01-31 2.0 HOW AMINO-ACID INSERTIONS ARE ALLOWED IN AN ALPHA-HELIX OF T4 LYSOZYME
4YX7 2015-06-03 2.0 Complex of SpaO(SPOA1,2) and OrgB(APAR)::T4lysozyme fusion protein
5V83 2017-05-24 2.0 Structure of DCN1 bound to NAcM-HIT
1C65 2000-10-04 2.0 T4 LYSOZYME MUTANT C54T/C97A/L121A IN THE PRESENCE OF 8 ATM XENON
1C64 2000-10-04 2.0 T4 LYSOZYME MUTANT C54T/C97A/L121A IN THE PRESENCE OF 8 ATM KRYPTON
227L 1998-03-18 2.0 GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS
198L 1996-03-08 2.0 THERMODYNAMIC AND STRUCTURAL COMPENSATION IN 'SIZE-SWITCH' CORE-REPACKING VARIANTS OF T4 LYSOZYME
147L 1994-01-31 2.0 ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4 LYSOZYME
1L85 1993-10-31 2.0 SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
1PQK 2003-10-07 2.0 Repacking of the Core of T4 Lysozyme by Automated Design
2OEA 2007-01-30 2.01 High-pressure structure of pseudo-WT T4 Lysozyme
2OE9 2007-01-30 2.01 High-pressure structure of pseudo-WT T4 Lysozyme
1T6H 2004-10-26 2.01 Crystal Structure T4 Lysozyme incorporating an unnatural amino acid p-iodo-L-phenylalanine at position 153
1CX6 1999-12-15 2.01 T4 LYSOZYME SUBSTITUTED WITH SELENOMETHIONINE
3HT9 2009-11-03 2.02 2-methoxyphenol in complex with T4 lysozyme L99A/M102Q
1L0K 2003-06-03 2.02 METHIONINE CORE MUTANT OF T4 LYSOZYME
1L77 1993-04-15 2.05 DESIGN AND STRUCTURAL ANALYSIS OF ALTERNATIVE HYDROPHOBIC CORE PACKING ARRANGEMENTS IN BACTERIOPHAGE T4 LYSOZYME
1CUQ 1999-11-10 2.05 T4 LYSOZYME MUTANT V103M
1D3F 1999-10-08 2.05 N-TERMINAL DOMAIN CORE METHIONINE MUTATION
218L 1996-12-23 2.05 PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
1CU5 1999-11-10 2.05 T4 LYSOZYME MUTANT L91M
1KY1 2003-06-03 2.05 METHIONINE CORE MUTANT OF T4 LYSOZYME
1D2Y 1999-10-08 2.06 N-TERMINAL DOMAIN CORE METHIONINE MUTATION
2OTZ 2007-08-07 2.07 N-methylaniline in complex with T4 Lysozyme L99A
3GUL 2009-08-25 2.07 T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--ethylbenzene binding
1DYG 1993-10-31 2.1 DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME
1C6M 2000-10-04 2.1 T4 LYSOZYME MUTANT C54T/C97A/L99A/F153A IN THE PRESENCE OF 8 ATM KRYPTON
2OE7 2007-01-30 2.1 High-Pressure T4 Lysozyme
1DYC 1993-10-31 2.1 DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME
1DYD 1993-10-31 2.1 DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME
197L 1996-03-08 2.1 THERMODYNAMIC AND STRUCTURAL COMPENSATION IN 'SIZE-SWITCH' CORE-REPACKING VARIANTS OF T4 LYSOZYME
216L 1994-07-31 2.1 STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
1C6A 2000-10-04 2.1 T4 LYSOZYME MUTANT C54T/C97A/L133A IN THE PRESENCE OF 8 ATM KRYPTON
1LWK 2003-05-20 2.1 Multiple Methionine Substitutions are Tolerated in T4 Lysozyme and have Coupled Effects on Folding and Stability
3G3V 2009-05-05 2.1 Crystal structure of spin labeled T4 Lysozyme (V131R1) at 291 K
1C66 2000-10-04 2.1 T4 LYSOZYME MUTANT C54T/C97A/L121A/L133A IN THE PRESENCE OF 8 ATM ARGON
2B6T 2005-11-08 2.1 T4 Lysozyme mutant L99A at 200 MPa
1L82 1993-04-15 2.1 DESIGN AND STRUCTURAL ANALYSIS OF ALTERNATIVE HYDROPHOBIC CORE PACKING ARRANGEMENTS IN BACTERIOPHAGE T4 LYSOZYME
1OV5 2004-04-06 2.1 T4 Lysozyme Cavity Mutant L99a/M102Q Bound With 2-Allylphenol
1CU6 1999-11-17 2.1 T4 LYSOZYME MUTANT L91A
2B74 2005-11-08 2.1 T4 Lysozyme mutant L99A at 100 MPa
1CV1 1999-11-10 2.1 T4 LYSOZYME MUTANT V111M
140L 1994-01-31 2.1 ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4 LYSOZYME
1OVK 2004-04-06 2.1 T4 Lysozyme Cavity Mutant L99A/M102Q Bound with N-Allyl-Aniline
205L 1994-01-31 2.1 HOW AMINO-ACID INSERTIONS ARE ALLOWED IN AN ALPHA-HELIX OF T4 LYSOZYME
2B75 2005-11-08 2.1 T4 Lysozyme mutant L99A at 150 MPa
1QT4 1999-07-08 2.1 T26Q MUTANT OF T4 LYSOZYME
252L 1998-03-18 2.1 GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS
1CTW 1999-11-10 2.1 T4 LYSOZYME MUTANT I78A
2Q9E 2007-06-26 2.1 Structure of spin-labeled T4 lysozyme mutant S44R1
2B72 2005-11-08 2.1 T4 Lysozyme mutant L99A at 100 MPa
144L 1994-01-31 2.1 ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4 LYSOZYME
2OE4 2007-01-30 2.1 High Pressure Psuedo Wild Type T4 Lysozyme
175L 1995-07-10 2.1 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
2B6X 2005-11-08 2.11 T4 Lysozyme mutant L99A at 200 MPa
1D3M 1999-09-30 2.12 METHIONINE CORE MUTATION
4S0W 2015-02-04 2.12 Wild type T4 lysozyme structure
1CV0 1999-11-10 2.12 T4 LYSOZYME MUTANT F104M
1CU3 1999-11-10 2.12 T4 LYSOZYME MUTANT V87M
1SSW 2004-10-19 2.13 Crystal structure of phage T4 lysozyme mutant Y24A/Y25A/T26A/I27A/C54T/C97A
213L 1996-12-23 2.13 PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
1T8F 2004-10-19 2.15 Crystal structure of phage T4 lysozyme mutant R14A/K16A/I17A/K19A/T21A/E22A/C54T/C97A
2B73 2005-11-08 2.15 T4 Lysozyme mutant L99A at 100 MPa
1KS3 2003-06-03 2.16 METHIONINE CORE MUTANT OF T4 LYSOZYME
3GUO 2009-08-25 2.16 T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--phenol binding
176L 1995-07-10 2.2 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
1C6B 2000-10-04 2.2 T4 LYSOZYME MUTANT C54T/C97A/L133A IN THE PRESENCE OF 8 ATM XENON
5X93 2017-08-16 2.2 Human endothelin receptor type-B in complex with antagonist K-8794
5VNQ 2017-07-26 2.2 Neutron crystallographic strucutre of perdeuterated T4 lysozyme cysteine-free pseudo-wild type at cryogenic temperature
2B6W 2005-11-08 2.2 T4 Lysozyme mutant L99A at 200 MPa
1C6N 2000-10-04 2.2 T4 LYSOZYME MUTANT C54T/C97A/L99A/F153A IN THE PRESENCE OF 8 ATM XENON
1C67 2000-10-04 2.2 T4 LYSOZYME MUTANT C54T/C97A/L121A/L133A IN THE PRESENCE OF 8 ATM KRYPTON
5TZR 2017-06-07 2.2 GPR40 in complex with partial agonist MK-8666
3VW7 2012-12-12 2.2 Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom
167L 1995-07-10 2.2 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
1CU0 1999-11-10 2.2 T4 LYSOZYME MUTANT I78M
151L 1994-04-30 2.2 CONSERVATION OF SOLVENT-BINDING SITES IN 10 CRYSTAL FORMS OF T4 LYSOZYME
6FFI 2018-03-07 2.2 Crystal Structure of mGluR5 in complex with MMPEP at 2.2 A
150L 1994-04-30 2.2 CONSERVATION OF SOLVENT-BINDING SITES IN 10 CRYSTAL FORMS OF T4 LYSOZYME
3GUM 2009-08-25 2.24 T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--p-xylene binding
5VBA 2017-07-05 2.27 Structure of EspG1 chaperone from the type VII (ESX-1) secretion system determined with the assistance of N-terminal T4 lysozyme fusion
4IAP 2013-07-31 2.3 Crystal structure of PH domain of Osh3 from Saccharomyces cerevisiae
174L 1995-07-10 2.3 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
1C62 2000-10-04 2.3 T4 LYSOZYME MUTANT C54T/C97A/F153A IN THE PRESENCE OF 8 ATM XENON
1JTN 2002-03-20 2.3 Alternative Structures of a Sequence Extended T4 Lysozyme Show that the Highly Conserved Beta-Sheet Region has weak intrinsic Folding Propensity
3G3W 2009-05-05 2.3 Crystal structure of spin labeled T4 Lysozyme (T151R1) at 291 K
196L 1996-03-08 2.3 THERMODYNAMIC AND STRUCTURAL COMPENSATION IN 'SIZE-SWITCH' CORE-REPACKING VARIANTS OF T4 LYSOZYME
1QTV 1999-07-08 2.3 T26E APO STRUCTURE OF T4 LYSOZYME
4PHU 2014-07-16 2.33 Crystal structure of Human GPR40 bound to allosteric agonist TAK-875
4YXA 2015-06-03 2.35 Complex of SpaO(SPOA1,2 SeMet) and OrgB(APAR)::T4lysozyme fusion protein
2HUM 2006-10-17 2.35 Crystal structure of T4 Lysozyme D72C synthetic dimer
2RH1 2007-10-30 2.4 High resolution crystal structure of human B2-adrenergic G protein-coupled receptor.
2QAR 2008-01-15 2.4 Structure of the 2TEL crystallization module fused to T4 lysozyme with a helical linker.
1SSY 2004-10-19 2.4 Crystal structure of phage T4 lysozyme mutant G28A/I29A/G30A/C54T/C97A
2B70 2005-11-08 2.4 T4 Lysozyme mutant L99A at ambient pressure
2B6Y 2005-11-08 2.4 T4 Lysozyme mutant L99A at ambient pressure
2B6Z 2005-11-08 2.4 T4 Lysozyme mutant L99A at ambient pressure
5YQR 2018-01-31 2.4 Crystal structure of the PH-like domain of Lam6
3SB9 2011-09-21 2.45 Cu-mediated Dimer of T4 Lysozyme R76H/R80H by Synthetic Symmetrization
3SB5 2011-09-21 2.46 Zn-mediated Trimer of T4 Lysozyme R125C/E128C by Synthetic Symmetrization
5D5A 2016-01-13 2.48 In meso in situ serial X-ray crystallography structure of the Beta2-adrenergic receptor at 100 K
6M9T 2018-12-05 2.5 Crystal structure of EP3 receptor bound to misoprostol-FA
177L 1995-07-10 2.5 Protein flexibility and adaptability seen in 25 crystal forms of T4 LYSOZYME
1C68 2000-10-04 2.5 T4 LYSOZYME MUTANT C54T/C97A/L121A/L133A IN THE PRESENCE OF 8 ATM XENON
1P5C 2004-05-04 2.5 Circular permutation of Helix A in T4 lysozyme
5EE7 2016-04-20 2.5 Crystal structure of the human glucagon receptor (GCGR) in complex with the antagonist MK-0893
261L 1999-05-24 2.5 STRUCTURAL CHARACTERISATION OF AN ENGINEERED TANDEM REPEAT CONTRASTS THE IMPORTANCE OF CONTEXT AND SEQUENCE IN PROTEIN FOLDING
231L 1998-01-14 2.5 T4 LYSOZYME MUTANT M106K
1OYU 2003-07-08 2.5 Long-Distance conformational changes in a protein engineered by modulated sequence duplication
189L 1995-07-31 2.5 ENHANCEMENT OF PROTEIN STABILITY BY THE COMBINATION OF POINT MUTATIONS IN T4 LYSOZYME IS ADDITIVE
3ODU 2010-10-27 2.5 The 2.5 A structure of the CXCR4 chemokine receptor in complex with small molecule antagonist IT1t
262L 1999-05-24 2.5 STRUCTURAL CHARACTERISATION OF AN ENGINEERED TANDEM REPEAT CONTRASTS THE IMPORTANCE OF CONTEXT AND SEQUENCE IN PROTEIN FOLDING
171L 1995-07-10 2.5 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
5GLI 2016-09-07 2.5 Human endothelin receptor type-B in the ligand-free form
1QTD 1999-07-22 2.5 THE INTRODUCTION OF STRAIN AND ITS EFFECTS ON THE STRUCTURE AND STABILITY OF T4 LYSOZYME
1QTC 1999-07-22 2.5 THE INTRODUCTION OF STRAIN AND ITS EFFECTS ON THE STRUCTURE AND STABILITY OF T4 LYSOZYME
1QS5 1999-07-02 2.5 THE INTRODUCTION OF STRAIN AND ITS EFFECTS ON THE STRUCTURE AND STABILITY OF T4 LYSOZYME
2QB0 2008-10-14 2.56 Structure of the 2TEL crystallization module fused to T4 lysozyme with an Ala-Gly-Pro linker.
4ARJ 2012-05-09 2.59 Crystal structure of a pesticin (translocation and receptor binding domain) from Y. pestis and T4-lysozyme chimera
4XES 2015-07-29 2.6 Structure of active-like neurotensin receptor
251L 1998-03-18 2.6 THE RESPONSE OF T4 LYSOZYME TO LARGE-TO-SMALL SUBSTITUTIONS WITHIN THE CORE AND ITS RELATION TO THE HYDROPHOBIC EFFECT
5CGD 2015-08-12 2.6 Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile - (HTL14242)
5DSG 2016-03-16 2.6 Structure of the M4 muscarinic acetylcholine receptor (M4-mT4L) bound to tiotropium
5EWX 2016-03-30 2.6 Fusion protein of T4 lysozyme and B4 domain of protein A from staphylococcal aureus with chemical cross-linker EY-CBS
4EXM 2012-06-20 2.6 The crystal structure of an engineered phage lysin containing the binding domain of pesticin and the killing domain of T4-lysozyme
149L 1994-04-30 2.6 CONSERVATION OF SOLVENT-BINDING SITES IN 10 CRYSTAL FORMS OF T4 LYSOZYME
1JQU 2002-03-06 2.6 Are Carboxy Terminii of Helices Coded by the Local Sequence or by Tertiary Structure Contacts
4OO9 2014-07-02 2.6 Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator mavoglurant
3EML 2008-10-14 2.6 The 2.6 A Crystal Structure of a Human A2A Adenosine Receptor bound to ZM241385.
5WF5 2018-02-21 2.6 Agonist bound human A2a adenosine receptor with D52N mutation at 2.60 A resolution
170L 1995-07-10 2.6 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
5JEA 2016-07-13 2.65 Structure of a cytoplasmic 11-subunit RNA exosome complex including Ski7, bound to RNA
3SB8 2011-09-21 2.65 Cu-mediated Dimer of T4 Lysozyme D61H/K65H by Synthetic Symmetrization
6FFH 2018-03-07 2.65 Crystal Structure of mGluR5 in complex with Fenobam at 2.65 A
5ZBQ 2018-04-25 2.7 The Crystal Structure of human neuropeptide Y Y1 receptor with UR-MK299
5VEW 2017-05-24 2.7 Structure of the human GLP-1 receptor complex with PF-06372222
209L 1996-12-23 2.7 PROTEIN STRUCTURE PLASTICITY EXEMPLIFIED BY INSERTION AND DELETION MUTANTS IN T4 LYSOZYME
3SB6 2011-09-21 2.7 Cu-mediated Dimer of T4 Lysozyme D61H/K65H/R76H/R80H by Synthetic Symmetrization
1T97 2004-08-17 2.7 Use of sequence duplication to engineer a ligand-triggered long-distance molecular switch in T4 Lysozyme
3SB7 2011-09-21 2.7 Cu-mediated Trimer of T4 Lysozyme D61H/K65H/R76H/R80H by Synthetic Symmetrization
5X7D 2017-08-16 2.7 Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist
6A9J 2019-03-20 2.7 Crystal structure of the PE-bound N-terminal domain of Atg2
6K1Q 2019-07-17 2.7 Human endothelin receptor type-B in complex with inverse agonist IRL2500
6J20 2019-03-06 2.7 Crystal structure of the human NK1 substance P receptor
5CXV 2016-03-09 2.7 Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium
3QAK 2011-03-09 2.71 Agonist bound structure of the human adenosine A2a receptor
178L 1995-07-10 2.71 Protein flexibility and adaptability seen in 25 crystal forms of T4 LYSOZYME
6D27 2018-10-03 2.74 Crystal structure of the prostaglandin D2 receptor CRTH2 with CAY10471
3SBA 2011-09-21 2.75 Zn-mediated Hexamer of T4 Lysozyme R76H/R80H by Synthetic Symmetrization
5KW2 2018-05-02 2.76 The extra-helical binding site of GPR40 and the structural basis for allosteric agonism and incretin stimulation
4LDE 2013-09-25 2.79 Structure of beta2 adrenoceptor bound to BI167107 and an engineered nanobody
4GRV 2012-10-17 2.8 The crystal structure of the neurotensin receptor NTS1 in complex with neurotensin (8-13)
5EUT 2015-12-23 2.8 Crystal structure of phosphatidyl inositol 4-kinase II alpha in the apo state
3D4S 2008-06-17 2.8 Cholesterol bound form of human beta2 adrenergic receptor.
3V2Y 2012-02-15 2.8 Crystal Structure of a Lipid G protein-Coupled Receptor at 2.80A
5GLH 2016-09-07 2.8 Human endothelin receptor type-B in complex with ET-1
4DKL 2012-03-21 2.8 Crystal structure of the mu-opioid receptor bound to a morphinan antagonist
6D26 2018-10-03 2.8 Crystal structure of the prostaglandin D2 receptor CRTH2 with fevipiprant
5NDD 2017-05-03 2.8 Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in complex with AZ8838 at 2.8 angstrom resolution
104L 1993-10-31 2.8 HOW AMINO-ACID INSERTIONS ARE ALLOWED IN AN ALPHA-HELIX OF T4 LYSOZYME
5T1A 2016-12-14 2.81 Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists
3NY8 2010-08-11 2.84 Crystal structure of the human beta2 adrenergic receptor in complex with the inverse agonist ICI 118,551
3NY9 2010-08-11 2.84 Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist
6CM4 2018-03-14 2.87 Structure of the D2 Dopamine Receptor Bound to the Atypical Antipsychotic Drug Risperidone
3PBL 2010-11-03 2.89 Structure of the human dopamine D3 receptor in complex with eticlopride
5ZKQ 2018-06-20 2.9 Crystal structure of the human platelet-activating factor receptor in complex with ABT-491
4XEE 2015-07-29 2.9 Structure of active-like neurotensin receptor
3OE0 2010-10-27 2.9 Crystal structure of the CXCR4 chemokine receptor in complex with a cyclic peptide antagonist CVX15
5WF6 2018-02-21 2.9 Agonist bound human A2a adenosine receptor with S91A mutation at 2.90 A resolution
6QAJ 2019-07-24 2.9 Structure of the tripartite motif of KAP1/TRIM28
4N9N 2014-12-03 2.9 Crystal Structure of Saccharomyces cerevisiae Upc2 Transcription Factor fused with T4 Lysozyme
168L 1995-07-10 2.9 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
4DJH 2012-03-21 2.9 Structure of the human kappa opioid receptor in complex with JDTic
6MXT 2018-11-14 2.96 Crystal structure of human beta2 adrenergic receptor bound to salmeterol and Nb71
4K5Y 2013-07-17 2.98 Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395
5YQZ 2018-01-17 3.0 Structure of the glucagon receptor in complex with a glucagon analogue
3UON 2012-02-01 3.0 Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
5ZBH 2018-04-25 3.0 The Crystal Structure of Human Neuropeptide Y Y1 Receptor with BMS-193885
3JR6 2009-10-20 3.0 Sequential reorganization of beta-sheet topology by insertion of a single strand
2B7X 2006-08-01 3.0 Sequential reorganization of beta-sheet topology by insertion of a single strand
5VEX 2017-05-17 3.0 Structure of the human GLP-1 receptor complex with NNC0640
5XEZ 2017-05-24 3.0 Structure of the Full-length glucagon class B G protein-coupled receptor
169L 1995-07-10 3.0 PROTEIN FLEXIBILITY AND ADAPTABILITY SEEN IN 25 CRYSTAL FORMS OF T4 LYSOZYME
5W0P 2017-08-09 3.01 Crystal structure of rhodopsin bound to visual arrestin determined by X-ray free electron laser
4LDL 2013-09-25 3.1 Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody
3OE8 2010-10-27 3.1 Crystal structure of the CXCR4 chemokine receptor in complex with a small molecule antagonist IT1t in P1 spacegroup
3RZE 2011-06-15 3.1 Structure of the human histamine H1 receptor in complex with doxepin
5ZHP 2018-11-28 3.1 M3 muscarinic acetylcholine receptor in complex with a selective antagonist
5CGC 2015-08-12 3.1 Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-4-fluoro-5-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile
3OE9 2010-10-27 3.1 Crystal structure of the chemokine CXCR4 receptor in complex with a small molecule antagonist IT1t in P1 spacegroup
4RWS 2015-02-11 3.1 Crystal structure of CXCR4 and viral chemokine antagonist vMIP-II complex (PSI Community Target)
3NYA 2010-08-11 3.16 Crystal structure of the human beta2 adrenergic receptor in complex with the neutral antagonist alprenolol
5XF1 2017-05-24 3.19 Structure of the Full-length glucagon class B G protein-coupled receptor
4TN3 2014-07-16 3.2 Structure of the BBox-Coiled-coil region of Rhesus Trim5alpha
5JQH 2016-07-13 3.2 Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60
3SN6 2011-07-20 3.2 Crystal structure of the beta2 adrenergic receptor-Gs protein complex
6J21 2019-03-06 3.2 Crystal structure of the human NK1 substance P receptor
6A9E 2019-03-20 3.2 Crystal structure of the N-terminal domain of Atg2
4LDO 2013-09-25 3.2 Structure of beta2 adrenoceptor bound to adrenaline and an engineered nanobody
5XSZ 2017-08-16 3.2 Crystal structure of zebrafish lysophosphatidic acid receptor LPA6
3OE6 2010-10-27 3.2 Crystal structure of the CXCR4 chemokine receptor in complex with a small molecule antagonist IT1t in I222 spacegroup
5D6L 2016-08-17 3.2 beta2AR-T4L - CIM
5TZY 2017-06-07 3.22 GPR40 in complex with AgoPAM AP8 and partial agonist MK-8666
5T04 2016-12-21 3.3 STRUCTURE OF CONSTITUTIVELY ACTIVE NEUROTENSIN RECEPTOR
4ZWJ 2015-07-29 3.3 Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
4QKX 2014-07-23 3.3 Structure of beta2 adrenoceptor bound to a covalent agonist and an engineered nanobody
3V2W 2012-02-15 3.35 Crystal Structure of a Lipid G protein-Coupled Receptor at 3.35A
4DAJ 2012-02-22 3.4 Structure of the M3 Muscarinic Acetylcholine Receptor
4EJ4 2012-05-16 3.4 Structure of the delta opioid receptor bound to naltrindole
3P0G 2011-01-19 3.5 Structure of a nanobody-stabilized active state of the beta2 adrenoceptor
3PDS 2011-01-12 3.5 Irreversible Agonist-Beta2 Adrenoceptor Complex
5B2G 2016-10-05 3.5 Crystal structure of human claudin-4 in complex with C-terminal fragment of Clostridium perfringens enterotoxin
4W8F 2014-11-12 3.54 Crystal structure of the dynein motor domain in the AMPPNP-bound state
4U14 2014-11-26 3.57 Structure of the M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized T4 lysozyme (dsT4L)
5NDZ 2017-05-03 3.6 Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in complex with AZ3451 at 3.6 angstrom resolution
5XPR 2017-08-16 3.6 Human endothelin receptor type-B in complex with antagonist bosentan
5D5B 2016-01-13 3.8 In meso X-ray crystallography structure of the Beta2-adrenergic receptor at 100 K
4GBR 2012-10-24 3.99 N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor
4HTT 2013-05-01 6.8 Crystal Structure of Twin Arginine Translocase Receptor- TatC in DDM
5DGY 2016-03-23 7.7 Crystal structure of rhodopsin bound to visual arrestin

Relevant UniProtKB Entries

Percent Identity Matching Chains Protein Accession Entry Name
100.0 Endolysin P00720 ENLYS_BPT4