Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21.
Abstract
A detailed understanding of the molecular mechanisms whereby ubiquitin (Ub) recognizes enzymes in the Ub proteasome system is crucial for understanding the biological function of Ub. Many structures of Ub complexes have been solved and, in most cases, reveal a large structural epitope on a common face of the Ub molecule. However, owing to the generally weak nature of these interactions, it has been difficult to map in detail the functional contributions of individual Ub side chains to affinity and specificity. Here we took advantage of Ub variants (Ubvs) that bind tightly to particular Ub-specific proteases (USPs) and used phage display and saturation scanning mutagenesis to comprehensively map functional epitopes within the structural epitopes. We found that Ubvs that bind to USP2 or USP21 contain a remarkably similar core functional epitope, or "hot spot," consisting mainly of positions that are conserved as the wild type sequence, but also some positions that prefer mutant sequences. The Ubv core functional epitope contacts residues that are conserved in the human USP family, and thus it is likely important for the interactions of Ub across many family members.
Submission Details
ID: VkahB8tt
Submitter: Marie Ary
Submission Date: June 14, 2017, 5:50 p.m.
Version: 1
Publication Details
Leung I;Dekel A;Shifman JM;Sidhu SS,Proc Natl Acad Sci U S A (2016) Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21. PMID:27436899Additional Information
Study Summary
Structure view and single mutant data analysis
Study data
| Colors: | D | E | R | H | K | S | T | N | Q | A | V | I | L | M | F | Y | W | C | G | P |
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Data Distribution
Studies with similar sequences (approximate matches)
Correlation with other assays (exact sequence matches)
Relevant PDB Entries
| Structure ID | Release Date | Resolution | Structure Title |
|---|---|---|---|
| 2L0T | 2010-12-15 | Solution structure of the complex of ubiquitin and the VHS domain of Stam2 | |
| 2G3Q | 2006-05-09 | Solution Structure of Ede1 UBA-ubiquitin complex | |
| 1C3T | 1999-08-20 | ROTAMER STRAIN AS A DETERMINANT OF PROTEIN STRUCTURAL SPECIFICITY | |
| 2N13 | 2016-03-09 | Complex structure of MyUb (1080-1122) of human Myosin VI with K63-diUb | |
| 2N3W | 2016-02-24 | Solution structure of the Rpn1 T1 site with K48-linked diubiquitin in the contracted binding mode | |
| 1FXT | 2001-10-10 | STRUCTURE OF A CONJUGATING ENZYME-UBIQUITIN THIOLESTER COMPLEX | |
| 1UD7 | 1999-05-06 | SOLUTION STRUCTURE OF THE DESIGNED HYDROPHOBIC CORE MUTANT OF UBIQUITIN, 1D7 | |
| 2K25 | 2008-09-30 | Automated NMR Structure of the UBB by FAPSY | |
| 2N3V | 2016-02-24 | Solution structure of the Rpn1 T1 site with K48-linked diubiquitin in the extended binding mode | |
| 2K8B | 2009-05-05 | Solution structure of PLAA family ubiquitin binding domain (PFUC) cis isomer in complex with ubiquitin | |
| 2NBE | 2016-05-18 | Solution structure of V26A mutant of Ubiquitin at pH 2.0 | |
| 2MRO | 2015-02-04 | Structure of the complex of ubiquitin and the UBA domain from DNA-damage-inducible 1 protein (Ddi1) | |
| 2LJ5 | 2012-07-18 | Description of the Structural fluctuations of proteins from structure-based calculations of Residual dipolar couplings | |
| 6KOX | 2019-08-28 | Relaxed state of S65/T66 double-phosphorylated ubiquitin | |
| 2NR2 | 2007-05-08 | The MUMO (minimal under-restraining minimal over-restraining) method for the determination of native states ensembles of proteins | |
| 2KTF | 2010-11-03 | Solution NMR structure of human polymerase iota UBM2 in complex with ubiquitin | |
| 2KHW | 2010-02-23 | Solution Structure of the human Polymerase iota UBM2-Ubiquitin Complex | |
| 6QF8 | 2019-04-10 | Solution NMR ensemble for human ubiquitin at 298K compiled using the CoMAND method | |
| 2PEA | 2007-07-10 | NMR Based Structure of the Closed Conformation of LYS48-Linked Di-Ubiquitin Using Experimental Global Rotational Diffusion Tensor from NMR Relaxation Measurements | |
| 1YX5 | 2005-04-19 | Solution Structure of S5a UIM-1/Ubiquitin Complex | |
| 2N3U | 2016-02-24 | Solution structure of the Rpn1 T1 site engaging two monoubiquitin molecules | |
| 2KDI | 2010-02-09 | Solution structure of a Ubiquitin/UIM fusion protein | |
| 2KOX | 2011-06-08 | NMR residual dipolar couplings identify long range correlated motions in the backbone of the protein ubiquitin | |
| 2L3Z | 2011-02-16 | Proton-Detected 4D DREAM Solid-State NMR Structure of Ubiquitin | |
| 5UJN | 2018-08-08 | Representative 2-conformer ensembles of K27-linked Ub2 from RDC data | |
| 1GJZ | 2001-12-13 | Solution structure of a dimeric N-terminal fragment of human ubiquitin | |
| 2NBD | 2016-05-18 | Solution structure of V26A mutant of Ubiquitin at pH 6.0 | |
| 2JRI | 2008-07-01 | Solution structure of the Josephin domain of Ataxin-3 in complex with ubiquitin molecule. | |
| 2KLG | 2009-10-06 | PERE NMR structure of ubiquitin | |
| 2FUH | 2006-03-28 | Solution Structure of the UbcH5c/Ub Non-covalent Complex | |
| 2MRE | 2014-10-22 | NMR structure of the Rad18-UBZ/ubiquitin complex | |
| 1YX6 | 2005-04-19 | Solution Structure of S5a UIM-2/Ubiquitin Complex | |
| 1OTR | 2003-06-24 | Solution Structure of a CUE-Ubiquitin Complex | |
| 2JT4 | 2007-09-25 | Solution Structure of the Sla1 SH3-3-Ubiquitin Complex | |
| 5XK5 | 2017-06-28 | Relaxed state of S65-phosphorylated ubiquitin | |
| 6KOW | 2019-08-28 | Retracted state of S65/T66 double-phosphorylated ubiquitin | |
| 2LD9 | 2011-06-08 | Backbone Structure of Ubiquitin determined using Backbone amide NOEs and Backbone N-H and N-C RDCs | |
| 1ZW7 | 2006-05-16 | Elimination of the C-cap in Ubiquitin Structure, Dynamics and Thermodynamic Consequences | |
| 2KJH | 2009-12-08 | NMR based structural model of the UBCH8-UBIQUITIN complex | |
| 2RR9 | 2011-07-06 | The solution structure of the K63-Ub2:tUIMs complex | |
| 6OQ2 | 2019-10-23 | NMR Structure of Branched K11/K48-Linked Tri-Ubiquitin | |
| 1ZGU | 2006-04-04 | Solution structure of the human Mms2-Ubiquitin complex | |
| 2MBH | 2013-10-09 | NMR structure of EKLF(22-40)/Ubiquitin Complex | |
| 1Q5W | 2004-03-30 | Ubiquitin Recognition by Npl4 Zinc-Fingers | |
| 2DEN | 2006-06-13 | Solution Structure of the Ubiquitin-Associated Domain of Human BMSC-UbP and its Complex with Ubiquitin | |
| 2RSU | 2013-03-27 | Alternative structure of Ubiquitin | |
| 5VEY | 2017-05-17 | Solution NMR structure of histone H2A-H2B mono-ubiquitylated at H2A Lys15 in complex with RNF169 (653-708) | |
| 6N13 | 2018-11-28 | UbcH7-Ub Complex with R0RBR Parkin and phosphoubiquitin | |
| 5XK4 | 2017-06-28 | Retracted state of S65-phosphorylated ubiquitin | |
| 2MWS | 2015-03-25 | Structure of the complex of ubiquitin and the ubiquitin-like (UBL) domain of Ddi1 | |
| 5ZD0 | 2019-08-21 | Solution structure of human ubiquitin with three alanine mutations in living eukaryotic cells by in-cell NMR spectroscopy | |
| 2MI8 | 2014-04-02 | Solution structure of lysine-free (K0) ubiquitin | |
| 2JZZ | 2008-03-25 | Solid-State NMR Structure of Microcrystalline Ubiquitin | |
| 2MOR | 2014-06-25 | A tensor-free method for the structural and dynamical refinement of proteins using residual dipolar couplings | |
| 2LVP | 2012-11-21 | gp78CUE domain bound to the distal ubiquitin of K48-linked diubiquitin | |
| 2KDE | 2009-09-01 | NMR structure of major S5a (196-306):K48 linked diubiquitin species | |
| 2K6D | 2008-08-19 | CIN85 Sh3-C domain in complex with ubiquitin | |
| 2JWZ | 2008-01-08 | Mutations in the hydrophobic core of ubiquitin differentially affect its recognition by receptor proteins | |
| 2K8C | 2009-05-05 | Solution structure of PLAA family ubiquitin binding domain (PFUC) trans isomer in complex with ubiquitin | |
| 2K39 | 2008-06-24 | Recognition dynamics up to microseconds revealed from RDC derived ubiquitin ensemble in solution | |
| 1WR1 | 2005-04-19 | The complex sturcture of Dsk2p UBA with ubiquitin | |
| 2PE9 | 2007-07-10 | NMR Based Structure of the Open Conformation of LYS48-Linked Di-UBiquitin Using Experimental Global Rotational Diffusion Tensor from NMR Relaxation Measurements | |
| 2RU6 | 2014-02-12 | The pure alternative state of ubiquitin | |
| 6K4I | 2019-10-30 | The partially disordered conformation of ubiquitin (Q41N variant) | |
| 2KN5 | 2009-11-17 | A Correspondence Between Solution-State Dynamics of an Individual Protein and the Sequence and Conformational Diversity of its Family | |
| 2MCN | 2014-02-05 | Distinct ubiquitin binding modes exhibited by SH3 domains: molecular determinants and functional implications | |
| 5VF0 | 2017-05-17 | Solution NMR structure of human RAD18 (198-240) in complex with ubiquitin | |
| 2N2K | 2015-07-08 | Ensemble structure of the closed state of Lys63-linked diubiquitin in the absence of a ligand | |
| 5XBO | 2017-05-31 | Lanthanoid tagging via an unnatural amino acid for protein structure characterization | |
| 2KX0 | 2010-09-08 | the solution structure of UBB+1, frameshift mutant of ubiquitin B | |
| 2Z59 | 2008-05-20 | Complex Structures of Mouse Rpn13 (22-130aa) and ubiquitin | |
| 2MBQ | 2013-09-04 | K11-linked Diubiquitin average solution structure at pH 6.8, 150 mM NaCl | |
| 2LVQ | 2012-11-21 | gp78CUE domain bound to the proximal ubiquitin of K48-linked diubiquitin | |
| 2MBO | 2013-09-04 | K11-linked Diubiquitin average solution structure at pH 6.8, 0 mM NaCl | |
| 1XQQ | 2005-02-08 | Simultaneous determination of protein structure and dynamics | |
| 2LZ6 | 2013-10-02 | Distinct ubiquitin binding modes exhibited by sh3 domains: molecular determinants and functional implications | |
| 2MJ5 | 2014-04-09 | Structure of the UBA Domain of Human NBR1 in Complex with Ubiquitin | |
| 1G6J | 2001-03-28 | STRUCTURE OF RECOMBINANT HUMAN UBIQUITIN IN AOT REVERSE MICELLES | |
| 2BGF | 2005-08-31 | NMR structure of Lys48-linked di-ubiquitin using chemical shift perturbation data together with RDCs and 15N-relaxation data | |
| 1V81 | 2005-02-15 | Solution structures of ubiquitin at 30 bar and 3 kbar | |
| 1V80 | 2005-02-15 | Solution structures of ubiquitin at 30 bar and 3 kbar | |
| 5VZM | 2018-05-23 | Solution NMR structure of human Rev1 (932-1039) in complex with ubiquitin | |
| 2JY6 | 2008-03-18 | Solution structure of the complex of ubiquitin and ubiquilin 1 UBA domain | |
| 2KDF | 2009-09-01 | NMR structure of minor S5a (196-306):K48 linked diubiquitin species | |
| 2KWV | 2010-10-06 | Solution Structure of UBM1 of murine Polymerase iota in Complex with Ubiquitin | |
| 2MJB | 2014-03-26 | Solution nmr structure of ubiquitin refined against dipolar couplings in 4 media | |
| 5UJL | 2017-10-25 | Representative 1-conformer ensembles of K27-linked Ub2 from RDC data | |
| 2LVO | 2012-11-21 | Structure of the gp78CUE domain bound to monubiquitin | |
| 2KWU | 2010-10-06 | Solution Structure of UBM2 of murine Polymerase iota in Complex with Ubiquitin | |
| 1E0Q | 2001-01-16 | Mutant Peptide from the first N-terminal 17 amino-acid of Ubiquitin | |
| 5YMY | 2019-03-13 | The structure of the complex between Rpn13 and K48-diUb | |
| 2MUR | 2014-12-03 | Solution Structure of the Human FAAP20 UBZ-Ubiquitin Complex | |
| 1Q0W | 2003-10-07 | Solution structure of Vps27 amino-terminal UIM-ubiquitin complex | |
| 1D3Z | 1999-10-14 | UBIQUITIN NMR STRUCTURE | |
| 2L0F | 2010-11-03 | Solution NMR structure of human polymerase iota UBM2 (P692A mutant) in complex with ubiquitin | |
| 2MSG | 2015-02-18 | Solid-state NMR structure of ubiquitin | |
| 2MBB | 2014-06-04 | Solution Structure of the human Polymerase iota UBM1-Ubiquitin Complex | |
| 2L00 | 2011-07-20 | Solution structure of the non-covalent complex of the ZNF216 A20 domain with ubiquitin | |
| 6V5D | 2020-01-01 | EROS3 RDC and NOE Derived Ubiquitin Ensemble | |
| 5NVG | 2017-05-31 | 1.07 | Thr12 Phosphorylated Ubiquitin |
| 5TOG | 2017-05-24 | 1.08 | Room temperature structure of ubiquitin variant u7ub25.2540 |
| 5TOF | 2017-05-24 | 1.12 | Room temperature structure of ubiquitin variant u7ub25 |
| 5GOB | 2016-11-02 | 1.15 | Lys6-linked di-ubiquitin |
| 4XOF | 2015-10-14 | 1.15 | Observing the overall rocking motion of a protein in a crystal - Orthorhombic Ubiquitin crystals without Zinc. |
| 5GOD | 2016-11-02 | 1.15 | Lys27-linked di-ubiquitin |
| 3A9J | 2009-12-08 | 1.18 | Crystal structure of the mouse TAB2-NZF in complex with Lys63-linked di-ubiquitin |
| 5W46 | 2017-07-05 | 1.18 | Structure of S65D Phosphomimetic Ubiquitin Refined at 1.2 Angstroms Resolution |
| 5XVE | 2018-02-28 | 1.24 | Crystal structure of human USP2 C276S mutant in complex with ubiquitin |
| 3NHE | 2010-06-30 | 1.26 | High Resolution Structure (1.26A) of USP2a in Complex with Ubiquitin |
| 5NL4 | 2017-04-26 | 1.32 | Crystal structure of Zn1.3-E16V human ubiquitin (hUb) mutant adduct, from a solution 35 mM zinc acetate/1.3 mM E16V hUb |
| 1OGW | 2003-05-30 | 1.32 | Synthetic Ubiquitin with fluoro-Leu at 50 and 67 |
| 5DK8 | 2015-12-16 | 1.32 | Human ubiquitin in the P1 space group |
| 2GBJ | 2006-05-16 | 1.35 | Crystal Structure of the 9-10 8 Glycine Insertion Mutant of Ubiquitin. |
| 2ZCC | 2007-11-20 | 1.4 | Ubiquitin crystallized under high pressure |
| 2WWZ | 2009-11-24 | 1.4 | TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked di-ubiquitin, P212121 |
| 3AI5 | 2010-09-29 | 1.4 | Crystal structure of yeast enhanced green fluorescent protein-ubiquitin fusion protein |
| 4HK2 | 2012-11-21 | 1.4 | U7Ub25.2540 |
| 4M0W | 2014-02-12 | 1.4 | Crystal Structure of SARS-CoV papain-like protease C112S mutant in complex with ubiquitin |
| 4Y1H | 2015-03-18 | 1.4 | Crystal structure of K33 linked tri-Ubiquitin |
| 3A9K | 2009-12-08 | 1.4 | Crystal structure of the mouse TAB3-NZF in complex with Lys63-linked di-ubiquitin |
| 5V1Y | 2017-05-03 | 1.42 | Crystal structure of the ternary RPN13 PRU-RPN2 (940-953)-ubiquitin complex |
| 5KYC | 2017-08-09 | 1.43 | Crystal structure of USP7 catalytic domain [V302K] mutant in complex with ubiquitin (malonate bound) |
| 1XD3 | 2004-11-23 | 1.45 | Crystal structure of UCHL3-UbVME complex |
| 6E2B | 2018-11-14 | 1.45 | Ubiquitin in complex with Pt(2-phenilpyridine)(PPh3) |
| 5KYF | 2017-08-09 | 1.45 | Crystal structure of USP7 catalytic domain [L299A] mutant in complex with ubiquitin |
| 4IUM | 2013-02-13 | 1.45 | Equine arteritis virus papain-like protease 2 (PLP2) covalently bound to ubiquitin |
| 5YT6 | 2018-07-11 | 1.5 | Crystal structure of TAX1BP1 UBZ2 in complex with mono-ubiquitin |
| 6NYO | 2019-08-07 | 1.5 | Crystal structure of a human Cdc34-ubiquitin thioester mimetic |
| 4PIH | 2014-10-29 | 1.5 | X-ray crystal structure of the K33S mutant of ubiquitin |
| 4PIJ | 2014-10-29 | 1.5 | X-ray crystal structure of the K11S/K63S double mutant of ubiquitin |
| 5NLF | 2017-05-03 | 1.5 | Crystal structure of Zn2.7-E16V human ubiquitin (hUb) mutant adduct, from a solution 100 mM zinc acetate/1.3 mM E16V hUb |
| 4UN2 | 2014-08-27 | 1.51 | Crystal structure of the UBA domain of Dsk2 in complex with Ubiquitin |
| 5NLI | 2017-05-03 | 1.53 | Crystal structure of Zn2-E16V human ubiquitin (hUb) mutant adduct, from a solution 35 mM zinc acetate/10% v/v TFE/1.3 mM E16V hUb |
| 5NLJ | 2017-04-26 | 1.53 | Crystal structure of Zn3-E16V human ubiquitin (hUb) mutant adduct, from a solution 70 mM zinc acetate/20% v/v TFE/1.3 mM E16V hUb |
| 4V3L | 2015-04-08 | 1.53 | RNF38-UB-UbcH5B-Ub complex |
| 4ZPZ | 2015-06-10 | 1.54 | Crystal Structure of Semi-synthetic Ubiquitin with Phospho-Ser65 and Ala46Cys |
| 3BY4 | 2008-02-19 | 1.55 | Structure of Ovarian Tumor (OTU) domain in complex with Ubiquitin |
| 5K9P | 2016-07-20 | 1.55 | Ser20 phosphorylated ubiquitin |
| 2GBM | 2006-05-16 | 1.55 | Crystal Structure of the 35-36 8 Glycine Insertion Mutant of Ubiquitin |
| 5J8P | 2016-05-18 | 1.55 | Lys27-linked diubiquitin |
| 5GOJ | 2016-11-02 | 1.55 | Lys63-linked di-ubiquitin |
| 4LJO | 2013-10-16 | 1.56 | Structure of an active ligase (HOIP)/ubiquitin transfer complex |
| 5GOI | 2016-11-02 | 1.59 | Lys48-linked di-ubiquitin |
| 2ZNV | 2008-09-02 | 1.6 | Crystal structure of human AMSH-LP DUB domain in complex with Lys63-linked ubiquitin dimer |
| 6FDK | 2018-08-15 | 1.6 | Structure of Chlamydia trachomatis effector protein Cdu1 bound to ubiquitin |
| 2ZCB | 2007-11-20 | 1.6 | Crystal Structure of ubiquitin P37A/P38A |
| 5OXH | 2017-11-22 | 1.6 | C-terminally retracted ubiquitin T66V/L67N mutant |
| 2GBN | 2006-05-16 | 1.6 | Crystal Structure of the 35-36 8 Glycine Insertion Mutant of Ubiquitin |
| 3M3J | 2010-03-23 | 1.6 | A new crystal form of Lys48-linked diubiquitin |
| 5KYD | 2017-08-09 | 1.62 | Crystal structure of USP7 catalytic domain [V302K] mutant in complex with ubiquitin |
| 5OXI | 2017-11-22 | 1.63 | C-terminally retracted ubiquitin L67S mutant |
| 4K1R | 2014-04-23 | 1.63 | Crystal structure of Schizosaccharomyces pombe sst2 catalytic domain and Ubiquitin |
| 6HEI | 2019-03-27 | 1.64 | Structure of the catalytic domain of USP28 (insertion deleted) bound to Ubiquitin-PA |
| 5X3N | 2017-04-12 | 1.65 | Crystal structure of DiUb-K6 |
| 4XYZ | 2015-03-18 | 1.65 | Crystal structure of K33 linked di-Ubiquitin |
| 5EMZ | 2016-11-16 | 1.66 | Crystal structure of K48-linked diubiquitin with F45W mutation in the proximal unit |
| 5AF5 | 2015-03-25 | 1.68 | Structure of Lys33-linked triUb S.G. P 212121 |
| 6HPR | 2018-12-12 | 1.7 | Crystal structure of cIAP1 RING domain bound to UbcH5B-Ub and a non-covalent Ub |
| 3V6C | 2012-12-19 | 1.7 | Crystal Structure of USP2 in complex with mutated ubiquitin |
| 4I6N | 2013-05-29 | 1.7 | Crystal structure of Trichinella spiralis UCH37 catalytic domain bound to Ubiquitin vinyl methyl ester |
| 5NMC | 2017-05-03 | 1.7 | Crystal structure of Zn3-hUb(human ubiquitin) adduct from a solution 70 mM zinc acetate/20% v/v TFE/1.3 mM hUb |
| 3B08 | 2011-12-14 | 1.7 | Crystal structure of the mouse HOIL1-L-NZF in complex with linear di-ubiquitin |
| 3VUX | 2013-02-13 | 1.7 | Crystal structure of A20 ZF7 in complex with linear ubiquitin, form II |
| 6B7M | 2018-04-18 | 1.7 | Crystal structure of Legionella effector sdeD (lpg2509) in complex with Ubiquitin |
| 1P3Q | 2003-06-24 | 1.7 | Mechanism of Ubiquitin Recognition by the CUE Domain of VPS9 |
| 1BT0 | 1998-12-30 | 1.7 | STRUCTURE OF UBIQUITIN-LIKE PROTEIN, RUB1 |
| 2D3G | 2005-12-20 | 1.7 | Double sided ubiquitin binding of Hrs-UIM |
| 6A42 | 2018-10-24 | 1.7 | R1EN(5-223)-ubiquitin fusion |
| 3NS8 | 2011-07-20 | 1.71 | Crystal structure of an open conformation of Lys48-linked diubiquitin at pH 7.5 |
| 4ZFR | 2015-10-14 | 1.72 | Catalytic domain of Sst2 F403A mutant bound to ubiquitin |
| 6EI1 | 2018-03-07 | 1.73 | Crystal structure of the covalent complex between deubiquitinase ZUFSP (ZUP1) and Ubiquitin-PA |
| 5GOC | 2016-11-02 | 1.73 | Lys11-linked diubiquitin |
| 6FGE | 2018-04-04 | 1.74 | Crystal structure of human ZUFSP/ZUP1 in complex with ubiquitin |
| 4MSM | 2014-06-18 | 1.74 | Crystal structure of Schizosaccharomyces pombe AMSH-like protease sst2 E286A mutant bound to ubiquitin |
| 1WRD | 2005-10-11 | 1.75 | Crystal structure of Tom1 GAT domain in complex with ubiquitin |
| 4K7S | 2013-05-08 | 1.76 | Crystal structure of Zn2-hUb (human ubiquitin) adduct from a solution 35 mM zinc acetate/1.3 mM hUb |
| 4K7U | 2013-05-08 | 1.76 | Crystal structure of Zn2.3-hUb (human ubiquitin) adduct from a solution 70 mM zinc acetate/1.3 mM hUb |
| 4K7W | 2013-05-08 | 1.76 | Crystal structure of Zn3-hUb(human ubiquitin) adduct from a solution 100 mM zinc acetate/1.3 mM hUb |
| 6OI4 | 2019-05-15 | 1.76 | RPN13 (19-132)-RPN2 (940-952) pY950-Ub complex |
| 5XIS | 2018-03-07 | 1.78 | Crystal structure of RNF168 UDM1 in complex with Lys63-linked diubiquitin, form I |
| 4HJK | 2012-11-21 | 1.78 | U7Ub7 Disulfide variant |
| 3N32 | 2011-01-12 | 1.79 | The crystal structure of human Ubiquitin adduct with Zeise's salt |
| 5M93 | 2016-12-14 | 1.79 | Crystal structure of SdeA-modified ubiquitin. |
| 5XIU | 2018-03-07 | 1.8 | Crystal structure of RNF168 UDM2 in complex with Lys63-linked diubiquitin |
| 4ZQS | 2016-04-20 | 1.8 | New compact conformation of linear Ub2 structure |
| 2J7Q | 2007-03-20 | 1.8 | Crystal structure of the ubiquitin-specific protease encoded by murine cytomegalovirus tegument protein M48 in complex with a ubquitin-based suicide substrate |
| 1UBQ | 1987-04-16 | 1.8 | STRUCTURE OF UBIQUITIN REFINED AT 1.8 ANGSTROMS RESOLUTION |
| 5ULF | 2017-06-07 | 1.8 | Crystal Structure of a UbcH5b~Ub conjugate |
| 6GLC | 2018-06-13 | 1.8 | Structure of phospho-Parkin bound to phospho-ubiquitin |
| 5GO7 | 2016-11-02 | 1.8 | Linear tri-ubiquitin |
| 3ONS | 2011-02-23 | 1.8 | Crystal structure of Human Ubiquitin in a new crystal form |
| 3K9O | 2010-09-08 | 1.8 | The crystal structure of E2-25K and UBB+1 complex |
| 1UBI | 1994-05-31 | 1.8 | SYNTHETIC STRUCTURAL AND BIOLOGICAL STUDIES OF THE UBIQUITIN SYSTEM. PART 1 |
| 3EHV | 2009-03-17 | 1.81 | X-ray structure of human ubiquitin Zn(II) adduct |
| 5XU8 | 2018-02-28 | 1.81 | Crystal structure of human USP2 in complex with ubiquitin and 6-thioguanine |
| 5X3M | 2017-04-05 | 1.82 | crystal structure of p-Ub-S65-NH2 |
| 5TXK | 2018-05-09 | 1.84 | CRYSTAL STRUCTURE OF USP35 C450S IN COMPLEX WITH UBIQUITIN |
| 3EFU | 2008-12-09 | 1.84 | X-ray structure of human ubiquitin-Hg(II) adduct |
| 5GOK | 2016-11-02 | 1.84 | K11/K63-branched tri-Ubiquitin |
| 3ALB | 2010-08-25 | 1.85 | Cyclic Lys48-linked tetraubiquitin |
| 2HD5 | 2006-08-15 | 1.85 | USP2 in complex with ubiquitin |
| 5WFI | 2018-08-01 | 1.85 | X-ray structure of MHV PLP2 (Cys1716Ser) catalytic mutant in complex with free ubiquitin |
| 2QHO | 2007-09-25 | 1.85 | Crystal structure of the UBA domain from EDD ubiquitin ligase in complex with ubiquitin |
| 5L8H | 2016-09-28 | 1.85 | Structure of USP46-UbVME |
| 5AF4 | 2015-03-25 | 1.85 | Structure of Lys33-linked diUb |
| 6B7O | 2018-04-18 | 1.85 | Crystal structure of Legionella effector sdeD (lpg2509) H67A in complex with ADP-ribosylated Ubiquitin |
| 1UZX | 2004-03-30 | 1.85 | A complex of the Vps23 UEV with ubiquitin |
| 4Q5E | 2014-07-02 | 1.87 | Shigella Effector Kinase OspG bound to E2-Ub UbcH7-Ub Conjugate |
| 6ISU | 2019-02-06 | 1.87 | Crystal structure of Lys27-linked di-ubiquitin in complex with its selective interacting protein UCHL3 |
| 5GVI | 2017-09-13 | 1.87 | Zebrafish USP30 in complex with Lys6-linked diubiquitin |
| 3MHS | 2010-04-21 | 1.89 | Structure of the SAGA Ubp8/Sgf11/Sus1/Sgf73 DUB module bound to ubiquitin aldehyde |
| 2OOB | 2007-02-06 | 1.9 | crystal structure of the UBA domain from Cbl-b ubiquitin ligase in complex with ubiquitin |
| 6GZS | 2018-11-14 | 1.9 | Structure of Chlamydia trachomatis effector protein ChlaDUB1 bound to ubiquitin |
| 3B0A | 2011-12-14 | 1.9 | Crystal structure of the mouse HOIL1-L-NZF in complex with linear di-ubiquitin |
| 3H7P | 2009-09-22 | 1.9 | Crystal structure of K63-linked di-ubiquitin |
| 3ZNZ | 2013-06-26 | 1.9 | Crystal structure of OTULIN OTU domain (C129A) in complex with Met1- di ubiquitin |
| 4LDT | 2013-08-14 | 1.9 | The structure of h/ceOTUB1-ubiquitin aldehyde-UBCH5B~Ub |
| 5CVM | 2015-10-07 | 1.9 | USP46~ubiquitin BEA covalent complex |
| 4WZP | 2015-01-14 | 1.9 | Ser65 phosphorylated ubiquitin, major conformation |
| 3WWQ | 2015-05-13 | 1.9 | Crystal structure of FAAP20 UBZ domain in complex with Lys63-linked diubiquitin |
| 5D0M | 2015-12-09 | 1.91 | Structure of UbE2D2:RNF165:Ub complex |
| 3TMP | 2012-01-11 | 1.91 | The catalytic domain of human deubiquitinase DUBA in complex with ubiquitin aldehyde |
| 2JF5 | 2008-02-05 | 1.95 | crystal structure of Lys63-linked di-ubiquitin |
| 4MSQ | 2014-06-18 | 1.95 | Crystal structure of Schizosaccharomyces pombe AMSH-like protease sst2 catalytic domain bound to ubiquitin |
| 6N6R | 2019-07-17 | 1.95 | Crystal structure of ABIN-1 UBAN in complex with two M1-linked di-ubiquitins |
| 5GOH | 2016-11-02 | 1.95 | Lys33-linked di-ubiquitin |
| 5ULH | 2017-06-07 | 1.95 | Structure of RNF165 in complex with a UbcH5b~Ub conjugate |
| 4PIG | 2014-10-29 | 1.95 | Crystal structure of the ubiquitin K11S mutant |
| 3VUW | 2013-02-13 | 1.95 | Crystal structure of A20 ZF7 in complex with linear ubiquitin, form I |
| 3HM3 | 2009-08-25 | 1.96 | The Structure and conformation of Lys-63 linked tetra-ubiquitin |
| 5NL5 | 2017-04-26 | 1.96 | Crystal structure of Zn1.7-E16V human ubiquitin (hUb) mutant adduct, from a solution 70 mM zinc acetate/1.3 mM E16V hUb |
| 5KYE | 2017-08-09 | 1.97 | Crystal structure of USP7 catalytic domain [H294E] mutant in complex with ubiquitin |
| 3VUY | 2013-02-13 | 1.98 | Crystal structure of A20 ZF7 in complex with linear tetraubiquitin |
| 5GOG | 2016-11-02 | 1.98 | Lys29-linked di-ubiquitin |
| 2GBK | 2006-05-16 | 1.99 | Crystal Structure of the 9-10 MoaD Insertion Mutant of Ubiquitin |
| 5JBY | 2016-07-20 | 1.99 | Lys27-linked triubiquitin |
| 2G45 | 2006-04-04 | 1.99 | Co-crystal structure of znf ubp domain from the deubiquitinating enzyme isopeptidase T (isot) in complex with ubiquitin |
| 2GBR | 2006-05-16 | 2.0 | Crystal Structure of the 35-36 MoaD Insertion Mutant of Ubiquitin |
| 5V1Z | 2017-05-03 | 2.0 | Crystal structure of the RPN13 PRU-RPN2 (932-953)-ubiquitin complex |
| 5YDR | 2018-02-21 | 2.0 | Structure of DNMT1 RFTS domain in complex with ubiquitin |
| 3PHW | 2011-02-02 | 2.0 | OTU Domain of Crimean Congo Hemorrhagic Fever Virus in complex with Ubiquitin |
| 4IG7 | 2013-05-29 | 2.0 | Crystal structure of Trichinella spiralis UCH37 bound to Ubiquitin vinyl methyl ester |
| 5WVO | 2017-11-15 | 2.0 | Crystal structure of DNMT1 RFTS domain in complex with K18/K23 mono-ubiquitylated histone H3 |
| 4Q5H | 2014-07-02 | 2.0 | Shigella Effector Kinase OspG bound to AMPPNP and E2-Ub UbcH7-Ub Conjugate |
| 5LRW | 2016-10-19 | 2.0 | Structure of Cezanne/OTUD7B OTU domain bound to ubiquitin |
| 5JG6 | 2016-06-15 | 2.0 | APC11-Ubv shows role of noncovalent RING-Ubiquitin interactions in processive multiubiquitination and Ubiquitin chain elongation by APC/C |
| 1S1Q | 2004-05-04 | 2.0 | TSG101(UEV) domain in complex with Ubiquitin |
| 4WLR | 2015-03-04 | 2.0 | Crystal Structure of mUCH37-hRPN13 CTD-hUb complex |
| 4V3K | 2015-04-08 | 2.04 | RNF38-UbcH5B-UB complex |
| 5HPS | 2016-03-16 | 2.05 | System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: WWP1 and UbV P1.1 |
| 4FJV | 2013-06-12 | 2.05 | Crystal Structure of Human Otubain2 and Ubiquitin Complex |
| 5MN9 | 2017-01-25 | 2.05 | Crystal structure of MINDY-1 tMIU in complex with K48-diUb |
| 6NYA | 2019-08-07 | 2.07 | Crystal Structure of ubiquitin E1 (Uba1) in complex with Ubc3 (Cdc34) and ubiquitin |
| 4XKL | 2015-11-11 | 2.1 | Crystal structure of NDP52 ZF2 in complex with mono-ubiquitin |
| 5DFL | 2015-12-02 | 2.1 | Crystal structure of Ube2K~Ubiquitin conjugate |
| 3V6E | 2012-12-19 | 2.1 | Crystal Structure of USP2 and a mutant form of Ubiquitin |
| 6JB7 | 2019-03-20 | 2.1 | Crystal structure of Ub-conjugated Ube2K C92K&K97A mutant (isopeptide linkage), 2.1 A resolution |
| 2C7N | 2006-02-15 | 2.1 | Human Rabex-5 residues 1-74 in complex with Ubiquitin |
| 6AQR | 2018-07-04 | 2.1 | SAGA DUB module Ubp8(C146A)/Sgf11/Sus1/Sgf73 bound to monoubiquitin |
| 5JBV | 2016-05-18 | 2.1 | Lys27-linked triubiquitin |
| 5BZ0 | 2016-06-15 | 2.1 | Crystal structure of IBV papain-like protease PLpro C101S mutant in complex with ubiquitin |
| 4RF1 | 2014-10-22 | 2.15 | Crystal structure of the Middle-East respiratory syndrome coronavirus papain-like protease in complex with ubiquitin (space group P63) |
| 4LJP | 2013-10-16 | 2.15 | Structure of an active ligase (HOIP-H889A)/ubiquitin transfer complex |
| 5MNJ | 2017-05-31 | 2.16 | Structure of MDM2-MDMX-UbcH5B-ubiquitin complex |
| 3Q3F | 2012-01-25 | 2.17 | Engineering Domain-Swapped Binding Interfaces by Mutually Exclusive Folding: Insertion of Ubiquitin into position 103 of Barnase |
| 5ZQ3 | 2018-05-23 | 2.18 | PDE-Ubiquitin |
| 4AUQ | 2012-08-15 | 2.18 | Structure of BIRC7-UbcH5b-Ub complex. |
| 1SIF | 2004-07-27 | 2.18 | Crystal structure of a multiple hydrophobic core mutant of ubiquitin |
| 3AXC | 2012-01-25 | 2.19 | Crystal structure of linear diubiquitin |
| 3NOB | 2010-08-11 | 2.19 | Structure of K11-linked di-ubiquitin |
| 5X3O | 2017-04-12 | 2.19 | Crystal structure of p-DiUb-S65-COOH |
| 3A1Q | 2009-07-21 | 2.2 | Crystal structure of the mouse RAP80 UIMs in complex with Lys63-linked di-ubiquitin |
| 4II2 | 2013-02-13 | 2.2 | Crystal structure of Ubiquitin activating enzyme 1 (Uba1) in complex with the Ub E2 Ubc4, ubiquitin, and ATP/Mg |
| 2XEW | 2010-07-14 | 2.2 | Crystal structure of K11-linked diubiquitin |
| 6OQ1 | 2019-10-23 | 2.2 | Crystal Structure of Branched K11/K48-Linked Tri-Ubiquitin |
| 2O6V | 2007-02-13 | 2.2 | Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH |
| 3A33 | 2009-11-24 | 2.2 | UbcH5b~Ubiquitin Conjugate |
| 4XOK | 2015-10-14 | 2.2 | Observing the overall rocking motion of a protein in a crystal. |
| 6NXK | 2020-01-15 | 2.2 | Ubiquitin binding variants |
| 5IFR | 2016-05-11 | 2.2 | Structure of the stable UBE2D3-UbDha conjugate |
| 2IBI | 2006-10-24 | 2.2 | Covalent Ubiquitin-USP2 Complex |
| 5TR4 | 2017-11-01 | 2.2 | Structure of Ubiquitin activating enzyme (Uba1) in complex with ubiquitin and TAK-243 |
| 3ZNI | 2013-07-10 | 2.21 | Structure of phosphoTyr363-Cbl-b - UbcH5B-Ub - ZAP-70 peptide complex |
| 5GO8 | 2016-11-02 | 2.21 | Linear tetra-ubiquitin |
| 5AIU | 2015-07-08 | 2.21 | A complex of RNF4-RING domain, Ubc13-Ub (isopeptide crosslink) |
| 6RYA | 2019-11-13 | 2.21 | Structure of Dup1 mutant H67A:Ubiquitin complex |
| 4AP4 | 2012-07-25 | 2.21 | Rnf4 - ubch5a - ubiquitin heterotrimeric complex |
| 5ZQ4 | 2018-05-23 | 2.22 | PDE-Ubi-ADPr |
| 6QK9 | 2019-07-24 | 2.23 | A dimeric ubiquitin formed by a single amino acid substitution |
| 5XIT | 2018-03-07 | 2.25 | Crystal structure of RNF168 UDM1 in complex with Lys63-linked diubiquitin, form II |
| 2W9N | 2009-04-28 | 2.25 | crystal structure of linear di-ubiquitin |
| 1CMX | 1999-07-27 | 2.25 | STRUCTURAL BASIS FOR THE SPECIFICITY OF UBIQUITIN C-TERMINAL HYDROLASES |
| 5XPK | 2017-07-19 | 2.27 | Crystal structure of ubiquitin-k6mimic |
| 5VZW | 2017-08-09 | 2.28 | TRIM23 RING domain in complex with UbcH5-Ub |
| 4R62 | 2015-09-02 | 2.28 | Structure of Rad6~Ub |
| 1NBF | 2003-01-07 | 2.3 | Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde |
| 3WXF | 2015-02-11 | 2.3 | Crystal structure of CYLD USP domain (C596S E674Q) in complex with Met1-linked diubiquitin |
| 1AAR | 1993-10-31 | 2.3 | STRUCTURE OF A DIUBIQUITIN CONJUGATE AND A MODEL FOR INTERACTION WITH UBIQUITIN CONJUGATING ENZYME (E2) |
| 3ZNH | 2013-02-27 | 2.3 | Crimean Congo Hemorrhagic Fever Virus OTU domain in complex with ubiquitin-propargyl. |
| 5L6H | 2017-06-14 | 2.3 | Uba1 in complex with Ub-ABPA3 covalent adduct |
| 4Z9S | 2015-07-29 | 2.3 | Non-covalent assembly of monoubiquitin that mimics K11 poly-ubiquitin |
| 4UEL | 2015-03-04 | 2.3 | UCH-L5 in complex with ubiquitin-propargyl bound to the RPN13 DEUBAD domain |
| 6PGV | 2019-10-23 | 2.3 | Human Josephin-2 in complex with ubiquitin |
| 4ZFT | 2015-10-14 | 2.3 | Catalytic domain of Sst2 F403W mutant bound to ubiquitin |
| 4S22 | 2015-04-08 | 2.3 | Crystal structure of K29 linked di-Ubiquitin |
| 3PRM | 2011-01-26 | 2.3 | Structural analysis of a viral OTU domain protease from the Crimean-Congo Hemorrhagic Fever virus in complex with human ubiquitin |
| 3H7S | 2009-09-22 | 2.3 | Crystal structures of K63-linked di- and tri-ubiquitin reveal a highly extended chain architecture |
| 2WDT | 2009-12-29 | 2.3 | Crystal structure of Plasmodium falciparum UCHL3 in complex with the suicide inhibitor UbVME |
| 4NQL | 2014-10-08 | 2.3 | The crystal structure of the DUB domain of AMSH orthologue, Sst2 from S. pombe, in complex with lysine 63-linked diubiquitin |
| 5HPL | 2016-03-16 | 2.31 | System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: Rsp5 and UbV R5.4 |
| 3C0R | 2008-02-19 | 2.32 | Structure of Ovarian Tumor (OTU) domain in complex with Ubiquitin |
| 5FER | 2016-05-18 | 2.34 | Complex of TRIM25 RING with UbcH5-Ub |
| 5OHK | 2017-09-20 | 2.34 | Crystal structure of USP30 in covalent complex with ubiquitin propargylamide (high resolution) |
| 6DGF | 2019-02-13 | 2.34 | Ubiquitin Variant bound to USP2 |
| 4BOS | 2013-07-24 | 2.35 | Structure of OTUD2 OTU domain in complex with Ubiquitin K11-linked peptide |
| 3UGB | 2012-05-16 | 2.35 | UbcH5c~Ubiquitin Conjugate |
| 4DHJ | 2012-02-22 | 2.35 | The structure of a ceOTUB1 ubiquitin aldehyde UBC13~Ub complex |
| 3OFI | 2010-09-08 | 2.35 | Crystal structure of human insulin-degrading enzyme in complex with ubiquitin |
| 6ASR | 2018-06-20 | 2.36 | REV1 UBM2 domain complex with ubiquitin |
| 5XDP | 2017-04-19 | 2.38 | K11/48-branched teraubiquitin |
| 5ULK | 2017-06-07 | 2.38 | Crystal Structure of RNF165 in complex with a UbcH5b~Ub conjugate |
| 3AUL | 2011-09-07 | 2.39 | Crystal structure of wild-type Lys48-linked diubiquitin in an open conformation |
| 3IFW | 2010-06-16 | 2.4 | Crystal structure of the S18Y variant of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester. |
| 4NNJ | 2014-05-07 | 2.4 | Crystal structure of Uba1 in complex with ubiquitin-AMP and thioesterified ubiquitin |
| 6A43 | 2018-10-24 | 2.4 | R1EN(5-225)-ubiquitin fusion |
| 2WX0 | 2009-11-24 | 2.4 | TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked di-ubiquitin, P21 |
| 5EYA | 2016-08-17 | 2.4 | TRIM25 RING domain in complex with Ubc13-Ub conjugate |
| 2C7M | 2006-02-15 | 2.4 | Human Rabex-5 residues 1-74 in complex with Ubiquitin |
| 4KSK | 2013-06-05 | 2.4 | Gumby/Fam105B in complex with ubiquitin |
| 3VDZ | 2012-11-28 | 2.4 | Tailoring Encodable Lanthanide-Binding Tags as MRI Contrast Agents: xq-dSE3-Ubiquitin at 2.4 Angstroms |
| 1TBE | 1994-01-31 | 2.4 | STRUCTURE OF TETRAUBIQUITIN SHOWS HOW MULTIUBIQUITIN CHAINS CAN BE FORMED |
| 6A44 | 2018-10-24 | 2.4 | R1EN(5-227)-ubiquitin fusion |
| 3VHT | 2012-10-10 | 2.4 | Crystal structure of GFP-Wrnip1 UBZ domain fusion protein in complex with ubiquitin |
| 3U30 | 2012-01-18 | 2.43 | Crystal structure of a linear-specific Ubiquitin fab bound to linear ubiquitin |
| 5HPK | 2016-03-16 | 2.43 | System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: NEDD4L and UbV NL.1 |
| 6IF1 | 2018-11-21 | 2.47 | Crystal structure of Ube2K and K48-linked di-ubiquitin complex |
| 4I6L | 2013-01-16 | 2.49 | Crystal structure of OTUB1 in complex with ubiquitin variant |
| 5ZQ5 | 2018-05-23 | 2.49 | SidE-Ubi |
| 2FIF | 2006-02-07 | 2.49 | Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin |
| 5BNB | 2016-02-17 | 2.49 | Crystal structure of a Ube2S-ubiquitin conjugate |
| 3OLM | 2011-03-23 | 2.49 | Structure and Function of a Ubiquitin Binding Site within the Catalytic Domain of a HECT Ubiquitin Ligase |
| 5U4P | 2017-09-06 | 2.5 | Protein-protein complex between 26S proteasome regulatory subunit RPN8, RPN11, and Ubiquitin S31 |
| 5IBK | 2016-03-30 | 2.5 | Skp1-F-box in complex with a ubiquitin variant |
| 5OHL | 2017-10-04 | 2.5 | K6-specific affimer bound to K6 diUb |
| 3OJ3 | 2010-12-08 | 2.5 | Crystal structure of the A20 ZnF4 and ubiquitin complex |
| 6FX4 | 2018-07-11 | 2.5 | Disulfide between E3 HECT ligase Smurf2 and Ubiquitin G76C |
| 3RUL | 2012-06-06 | 2.5 | New strategy to analyze structures of glycopeptide-target complexes |
| 3PT2 | 2011-01-19 | 2.5 | Structure of a viral OTU domain protease bound to Ubiquitin |
| 2GMI | 2006-09-19 | 2.5 | Mms2/Ubc13~Ubiquitin |
| 3WXE | 2015-02-11 | 2.5 | Crystal structure of CYLD USP domain (C596S) in complex with Met1-linked diubiquitin |
| 5J26 | 2016-12-14 | 2.5 | Crystal structure of a 53BP1 Tudor domain in complex with a ubiquitin variant |
| 5YDK | 2018-03-07 | 2.51 | Crystal structure of RNF168 UDM1 in complex with Lys63-linked diubiquitin, tetrameric form |
| 4BBN | 2013-05-01 | 2.51 | NEDD4 HECT-Ub:Ub complex |
| 3I3T | 2009-07-21 | 2.59 | Crystal structure of covalent ubiquitin-USP21 complex |
| 5H07 | 2017-03-08 | 2.59 | TNIP2-Ub complex, C2 form |
| 4HCN | 2012-11-21 | 2.6 | Crystal structure of Burkholderia pseudomallei effector protein CHBP in complex with ubiquitin |
| 5TUT | 2017-11-08 | 2.6 | UbcH5a-Ub isopeptide conjugate |
| 3DVG | 2008-09-30 | 2.6 | Crystal structure of K63-specific fab Apu.3A8 bound to K63-linked di-ubiquitin |
| 6O82 | 2019-06-19 | 2.6 | S. pombe ubiquitin E1 complex with a ubiquitin-AMP mimic |
| 6T4Q | 2019-12-25 | 2.6 | Structure of yeast 80S ribosome stalled on the CGA-CCG inhibitory codon combination. |
| 6A6I | 2019-02-13 | 2.6 | Crystal structure of the winged-helix domain of Cockayne syndrome group B protein in complex with ubiquitin |
| 3LDZ | 2010-03-02 | 2.6 | Crystal structure of human STAM1 VHS domain in complex with ubiquitin |
| 5N38 | 2017-04-19 | 2.6 | S65DParkin and pUB complex |
| 3N3K | 2010-06-23 | 2.6 | The catalytic domain of USP8 in complex with a USP8 specific inhibitor |
| 1WR6 | 2005-06-28 | 2.6 | Crystal structure of GGA3 GAT domain in complex with ubiquitin |
| 2OJR | 2007-06-12 | 2.6 | Structure of ubiquitin solved by SAD using the Lanthanide-Binding Tag |
| 4MDK | 2013-12-11 | 2.61 | Cdc34-ubiquitin-CC0651 complex |
| 6BYH | 2018-07-18 | 2.61 | Ubiquitin Variant (UbV.Fl11.1) bound to a human Skp1-Fbl11 fragment complex. |
| 5CAW | 2015-07-22 | 2.62 | Structure of Pediculus humanus Parkin bound to phospho-ubiquitin |
| 5CRA | 2015-11-25 | 2.64 | Structure of the SdeA DUB Domain |
| 5D0K | 2015-12-09 | 2.65 | Structure of UbE2D2:RNF165:Ub complex |
| 5JQS | 2016-06-22 | 2.65 | Crystal structure of deubiquitinase MINDY-1 in complex with Ubiquitin |
| 6BVA | 2018-07-18 | 2.66 | Ubiquitin Variant (UbV.Fl10.1) bound to a human Skp1-Fbl10 fragment complex. |
| 2XBB | 2011-03-23 | 2.68 | Nedd4 HECT:Ub complex |
| 5N2W | 2017-04-19 | 2.68 | WT-Parkin and pUB complex |
| 5L6J | 2017-06-14 | 2.68 | Uba1 in complex with Ub-MLN7243 covalent adduct |
| 5B83 | 2016-09-07 | 2.69 | Crystal structure of Optineurin UBAN in complex with linear ubiquitin |
| 2HTH | 2006-10-24 | 2.7 | Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain |
| 3DVN | 2008-09-30 | 2.7 | Crystal structure of K63-specific fab Apu2.16 bound to K63-linked di-ubiquitin |
| 3PTF | 2011-05-11 | 2.7 | X-ray structure of the non-covalent complex between UbcH5A and Ubiquitin |
| 4BVU | 2014-01-29 | 2.7 | Structure of Shigella effector OspG in complex with host UbcH5c- Ubiquitin conjugate |
| 2Y5B | 2012-01-25 | 2.7 | Structure of USP21 in complex with linear diubiquitin-aldehyde |
| 3CMM | 2008-08-05 | 2.7 | Crystal Structure of the Uba1-Ubiquitin Complex |
| 3JSV | 2009-10-27 | 2.7 | Crystal structure of mouse NEMO CoZi in complex with Lys63-linked di-ubiquitin |
| 3O65 | 2010-11-24 | 2.7 | Crystal structure of a Josephin-ubiquitin complex: Evolutionary restraints on ataxin-3 deubiquitinating activity |
| 3MTN | 2010-06-09 | 2.7 | Usp21 in complex with a ubiquitin-based, USP21-specific inhibitor |
| 1F9J | 2001-02-07 | 2.7 | STRUCTURE OF A NEW CRYSTAL FORM OF TETRAUBIQUITIN |
| 6JB6 | 2019-03-20 | 2.7 | Crystal structure of Ub-conjugated Ube2K C92K&K97A mutant (isopeptide linkage), 2.7 A resolution |
| 4MM3 | 2014-07-02 | 2.75 | Crystal structure of SARS-CoV papain-like protease PLpro in complex with ubiquitin aldehyde |
| 5L6I | 2017-06-14 | 2.76 | Uba1 in complex with Ub-MLN4924 covalent adduct |
| 5L8W | 2016-09-28 | 2.79 | Structure of USP12-UB-PRG/UAF1 |
| 4RF0 | 2014-10-22 | 2.8 | Crystal structure of the Middle-East respiratory syndrome coronavirus papain-like protease in complex with ubiquitin (space group P6522) |
| 1YD8 | 2005-02-22 | 2.8 | COMPLEX OF HUMAN GGA3 GAT DOMAIN AND UBIQUITIN |
| 4U4R | 2014-10-22 | 2.8 | Crystal structure of Lactimidomycin bound to the yeast 80S ribosome |
| 5OHP | 2017-09-20 | 2.8 | Crystal structure of USP30 (C77A) in complex with Lys6-linked diubiquitin |
| 3VFK | 2013-01-09 | 2.8 | The structure of monodechloro-teicoplanin in complex with its ligand, using ubiquitin as a ligand carrier |
| 3L0W | 2010-03-23 | 2.8 | Structure of split monoubiquitinated PCNA with ubiquitin in position two |
| 5LRV | 2016-10-19 | 2.8 | Structure of Cezanne/OTUD7B OTU domain bound to Lys11-linked diubiquitin |
| 6S53 | 2019-09-11 | 2.8 | Crystal structure of TRIM21 RING domain in complex with an isopeptide-linked Ube2N~ubiquitin conjugate |
| 3L10 | 2010-03-23 | 2.8 | Structure of split monoubiquitinated PCNA with ubiquitin in position one |
| 2FID | 2006-02-07 | 2.8 | Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin |
| 3K9P | 2010-09-08 | 2.8 | The crystal structure of E2-25K and ubiquitin complex |
| 3KVF | 2010-06-16 | 2.8 | Crystal structure of the I93M mutant of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester |
| 5OHV | 2017-10-04 | 2.8 | K33-specific affimer bound to K33 diUb |
| 3IHP | 2009-12-29 | 2.8 | Covalent Ubiquitin-Usp5 Complex |
| 4KSL | 2013-06-05 | 2.83 | Gumby/Fam105B in complex with linear di-ubiquitin |
| 3KW5 | 2010-06-16 | 2.83 | Crystal structure of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester |
| 5HPT | 2016-03-16 | 2.84 | System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: WWP1, Ubv P2.3 and UBCH7 |
| 5ZQ7 | 2018-05-23 | 2.85 | SidE-Ubi-NAD |
| 4HXD | 2013-02-13 | 2.85 | Diversity of ubiquitin and ISG15 specificity amongst nairoviruses viral ovarian tumor domain proteases |
| 5LRX | 2016-10-19 | 2.85 | Structure of A20 OTU domain bound to ubiquitin |
| 5E6J | 2016-05-18 | 2.85 | Structure of SARS PLpro bound to a Lys48-linked di-ubiquitin activity based probe |
| 4JQW | 2014-03-26 | 2.9 | Crystal Structure of a Complex of NOD1 CARD and Ubiquitin |
| 6CP2 | 2018-08-01 | 2.9 | SidC in complex with UbcH7~Ub |
| 4U3U | 2014-10-22 | 2.9 | Crystal structure of Cycloheximide bound to the yeast 80S ribosome |
| 6EK0 | 2018-01-24 | 2.9 | High-resolution cryo-EM structure of the human 80S ribosome |
| 6QZP | 2019-04-24 | 2.9 | High-resolution cryo-EM structure of the human 80S ribosome |
| 2ZVO | 2009-03-24 | 2.9 | NEMO CoZi domain in complex with diubiquitin in C2 space group |
| 3ZLZ | 2013-04-10 | 2.9 | Lys6-linked tri-ubiquitin |
| 4II3 | 2013-02-13 | 2.9 | Crystal structure of S. pombe Ubiquitin activating enzyme 1 (Uba1) in complex with ubiquitin and ATP/Mg |
| 3TBL | 2012-05-23 | 2.9 | Structure of Mono-ubiquitinated PCNA: Implications for DNA Polymerase Switching and Okazaki Fragment Maturation |
| 5JP3 | 2016-07-27 | 2.9 | Structure of Xanthomonas campestris effector protein XopD bound to ubiquitin |
| 6FYH | 2018-07-11 | 2.91 | Disulfide between ubiquitin G76C and the E3 HECT ligase Huwe1 |
| 4XOL | 2015-10-14 | 2.91 | Observing the overall rocking motion of a protein in a crystal - Cubic Ubiquitin crystals. |
| 5OE7 | 2017-09-27 | 2.95 | Structure of OTULIN bound to the Met1-linked diubiquitin activity probe |
| 5TBW | 2017-07-26 | 3.0 | Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome |
| 3N30 | 2011-01-12 | 3.0 | Crystal Structure of cubic Zn3-hUb (human ubiquitin) adduct |
| 3EEC | 2009-03-10 | 3.0 | X-ray structure of human ubiquitin Cd(II) adduct |
| 5C7J | 2016-03-16 | 3.0 | CRYSTAL STRUCTURE OF NEDD4 WITH A UB VARIANT |
| 4XKH | 2016-02-17 | 3.0 | CRYSTAL STRUCTURE OF THE AIRAPL TANDEM UIMS IN COMPLEX WITH A LYS48-LINKED TRI-UBIQUITIN |
| 3PHD | 2011-02-23 | 3.0 | Crystal structure of human HDAC6 in complex with ubiquitin |
| 3H1U | 2009-05-05 | 3.0 | Structure of ubiquitin in complex with Cd ions |
| 5WQ4 | 2017-12-06 | 3.0 | Crystal structure of OPTN and linear diubiquitin complex |
| 6MSB | 2018-12-05 | 3.0 | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome |
| 2XK5 | 2010-08-25 | 3.0 | Crystal structure of K6-linked diubiquitin |
| 4U4Q | 2014-10-22 | 3.0 | Crystal structure of Homoharringtonine bound to the yeast 80S ribosome |
| 4U4U | 2014-10-22 | 3.0 | Crystal structure of Lycorine bound to the yeast 80S ribosome |
| 4V88 | 2014-07-09 | 3.0 | The structure of the eukaryotic ribosome at 3.0 A resolution. |
| 2WX1 | 2009-11-24 | 3.0 | TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked tri-ubiquitin, P212121 |
| 4U52 | 2014-10-22 | 3.0 | Crystal structure of Nagilactone C bound to the yeast 80S ribosome |
| 2ZVN | 2009-03-24 | 3.0 | NEMO CoZi domain incomplex with diubiquitin in P212121 space group |
| 4U3M | 2014-10-22 | 3.0 | Crystal structure of Anisomycin bound to the yeast 80S ribosome |
| 5ZQ6 | 2018-05-23 | 3.01 | SidE-Ubi-ADPr |
| 6N5M | 2019-07-17 | 3.01 | Crystal structure of ABIN-1 UBAN in complex with one M1-linked di-ubiquitin |
| 6FYY | 2018-12-05 | 3.02 | Structure of a partial yeast 48S preinitiation complex with eIF5 N-terminal domain (model C2) |
| 4S1Z | 2015-04-08 | 3.03 | Crystal structure of TRABID NZF1 in complex with K29 linked di-Ubiquitin |
| 4BOZ | 2013-07-17 | 3.03 | Structure of OTUD2 OTU domain in complex with K11-linked di ubiquitin |
| 5C7M | 2016-03-16 | 3.03 | CRYSTAL STRUCTURE OF E3 LIGASE ITCH WITH A UB VARIANT |
| 6HEK | 2019-03-27 | 3.03 | Structure of human USP28 bound to Ubiquitin-PA |
| 5DGV | 2016-12-14 | 3.1 | Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog |
| 6OLE | 2019-06-19 | 3.1 | Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs |
| 4U4Z | 2014-10-22 | 3.1 | Crystal structure of Phyllanthoside bound to the yeast 80S ribosome |
| 5I4L | 2016-06-22 | 3.1 | Crystal structure of Amicoumacin A bound to the yeast 80S ribosome |
| 6HHQ | 2019-02-20 | 3.1 | Crystal structure of compound C45 bound to the yeast 80S ribosome |
| 6T7T | 2019-12-25 | 3.1 | Structure of yeast 80S ribosome stalled on poly(A) tract. |
| 6QIK | 2019-06-26 | 3.1 | Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles |
| 6Q8Y | 2019-03-13 | 3.1 | Cryo-EM structure of the mRNA translating and degrading yeast 80S ribosome-Xrn1 nuclease complex |
| 6EQI | 2017-11-08 | 3.1 | Structure of PINK1 bound to ubiquitin |
| 6OM0 | 2019-06-19 | 3.1 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE tRNAs |
| 5ON6 | 2018-02-28 | 3.1 | Crystal structure of haemanthamine bound to the 80S ribosome |
| 5FCJ | 2016-05-11 | 3.1 | Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome |
| 3JW0 | 2010-01-12 | 3.1 | E2~Ubiquitin-HECT |
| 4U6F | 2014-10-22 | 3.1 | Crystal structure of T-2 toxin bound to the yeast 80S ribosome |
| 4LCD | 2013-08-14 | 3.1 | Structure of an Rsp5xUbxSna3 complex: Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3 |
| 5YIK | 2018-05-30 | 3.1 | Structure of a Legionella effector with its substrate |
| 4U4N | 2014-10-22 | 3.1 | Crystal structure of Edeine bound to the yeast 80S ribosome |
| 3WXG | 2015-02-11 | 3.1 | Crystal structure of CYLD USP domain (C596A) in complex with Lys63-linked diubiquitin |
| 4DHZ | 2012-02-22 | 3.11 | The structure of h/ceOTUB1-ubiquitin aldehyde-UBC13~Ub |
| 5LN1 | 2016-10-19 | 3.14 | STRUCTURE OF UBIQUITYLATED-RPN10 FROM YEAST; |
| 6DC6 | 2018-10-10 | 3.14 | Crystal structure of human ubiquitin activating enzyme E1 (Uba1) in complex with ubiquitin |
| 5O44 | 2017-11-08 | 3.14 | Crystal structure of unbranched mixed tri-Ubiquitin chain containing K48 and K63 linkages. |
| 6O83 | 2019-06-19 | 3.15 | S. pombe ubiquitin E1~ubiquitin-AMP tetrahedral intermediate mimic |
| 5DAT | 2016-08-31 | 3.15 | Complex of yeast 80S ribosome with hypusine-containing eIF5A |
| 4WUR | 2014-11-26 | 3.16 | The crystal structure of the MERS-CoV papain-like protease (C111S) with human ubiquitin |
| 5YIJ | 2018-05-30 | 3.18 | Structure of a Legionella effector with substrates |
| 4U3N | 2014-10-22 | 3.2 | Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome |
| 5ZBU | 2019-02-27 | 3.2 | Crystal Structure of PA-TM-RING E3 ligase RNF13 RING domain in complex with E2~Ub |
| 4U55 | 2014-10-22 | 3.2 | Crystal structure of Cryptopleurine bound to the yeast 80S ribosome |
| 4U4Y | 2014-10-22 | 3.2 | Crystal structure of Pactamycin bound to the yeast 80S ribosome |
| 6T7I | 2019-12-25 | 3.2 | Structure of yeast 80S ribosome stalled on the CGA-CGA inhibitory codon combination. |
| 4U51 | 2014-10-22 | 3.2 | Crystal structure of Narciclasine bound to the yeast 80S ribosome |
| 4U50 | 2014-10-22 | 3.2 | Crystal structure of Verrucarin bound to the yeast 80S ribosome |
| 6KIU | 2019-09-11 | 3.2 | Cryo-EM structure of human MLL1-ubNCP complex (3.2 angstrom) |
| 6MSD | 2018-12-05 | 3.2 | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome |
| 5UDH | 2017-06-14 | 3.24 | HHARI/ARIH1-UBCH7~Ubiquitin |
| 5LYB | 2016-11-23 | 3.25 | Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCPmn |
| 5DC3 | 2016-06-01 | 3.25 | Complex of yeast 80S ribosome with non-modified eIF5A |
| 6C16 | 2018-07-18 | 3.27 | Ubiquitin variant (UbV.Fbl10.1) bound to a human Skp1-Fbl11 fragment complex. |
| 6S47 | 2019-07-24 | 3.28 | Saccharomyces cerevisiae 80S ribosome bound with ABCF protein New1 |
| 5DGF | 2016-12-14 | 3.3 | Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog |
| 4DDG | 2012-02-22 | 3.3 | Crystal structure of human OTUB1/UbcH5b~Ub/Ub |
| 6RI5 | 2019-06-26 | 3.3 | Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles |
| 6MSE | 2018-11-21 | 3.3 | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome |
| 5M1J | 2017-01-18 | 3.3 | Nonstop ribosomal complex bound with Dom34 and Hbs1 |
| 5NDV | 2017-12-13 | 3.3 | Crystal structure of Paromomycin bound to the yeast 80S ribosome |
| 5AN9 | 2015-10-21 | 3.3 | Mechanism of eIF6 release from the nascent 60S ribosomal subunit |
| 5TGA | 2016-11-23 | 3.3 | Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro |
| 5T62 | 2017-02-08 | 3.3 | Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis: 60S-Nmd3-Tif6-Lsg1 Complex |
| 6PX1 | 2019-08-28 | 3.3 | Set2 bound to nucleosome |
| 3JVZ | 2010-01-12 | 3.3 | E2~Ubiquitin-HECT |
| 6QKL | 2019-03-20 | 3.3 | Mechanism of eIF6 release from the nascent 60S ribosomal subunit |
| 4U53 | 2014-10-22 | 3.3 | Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome |
| 5JTV | 2016-10-12 | 3.31 | USP7CD-UBL45 in complex with Ubiquitin |
| 5JTJ | 2016-08-10 | 3.32 | USP7CD-CTP in complex with Ubiquitin |
| 2DX5 | 2006-10-10 | 3.35 | The complex structure between the mouse EAP45-GLUE domain and ubiquitin |
| 5CVN | 2015-10-07 | 3.36 | WDR48 (2-580):USP46~ubiquitin ternary complex |
| 6VEN | 2020-01-15 | 3.37 | Yeast COMPASS in complex with a ubiquitinated nucleosome |
| 5AIT | 2015-07-08 | 3.4 | A complex of of RNF4-RING domain, UbeV2, Ubc13-Ub (isopeptide crosslink) |
| 6HD7 | 2018-12-19 | 3.4 | Cryo-EM structure of the ribosome-NatA complex |
| 4P4H | 2014-07-30 | 3.4 | Caught-in-action signaling complex of RIG-I 2CARD domain and MAVS CARD domain |
| 3J7Q | 2014-09-03 | 3.4 | Structure of the idle mammalian ribosome-Sec61 complex |
| 5AF6 | 2015-03-25 | 3.4 | Structure of Lys33-linked diUb bound to Trabid NZF1 |
| 6R87 | 2019-06-26 | 3.4 | Yeast Vms1 (Q295L)-60S ribosomal subunit complex (pre-state without Arb1) |
| 5OBM | 2017-12-13 | 3.4 | Crystal structure of Gentamicin bound to the yeast 80S ribosome |
| 6R86 | 2019-07-31 | 3.4 | Yeast Vms1-60S ribosomal subunit complex (post-state) |
| 6OLG | 2019-06-19 | 3.4 | Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA) |
| 3OJ4 | 2010-12-08 | 3.4 | Crystal structure of the A20 ZnF4, ubiquitin and UbcH5A complex |
| 5FCI | 2016-05-11 | 3.4 | Structure of the vacant uL3 W255C mutant 80S yeast ribosome |
| 3J7O | 2014-09-03 | 3.4 | Structure of the mammalian 60S ribosomal subunit |
| 6QT0 | 2019-06-26 | 3.4 | Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles |
| 5APO | 2015-12-16 | 3.41 | Structure of the yeast 60S ribosomal subunit in complex with Arx1, Alb1 and C-terminally tagged Rei1 |
| 5VNZ | 2017-12-06 | 3.41 | Structure of a TRAF6-Ubc13~Ub complex |
| 5DGE | 2017-01-25 | 3.45 | Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome |
| 4U56 | 2014-10-22 | 3.45 | Crystal structure of Blasticidin S bound to the yeast 80S ribosome |
| 3JAM | 2015-08-12 | 3.46 | CryoEM structure of 40S-eIF1A-eIF1 complex from yeast |
| 5EDV | 2016-01-20 | 3.48 | Structure of the HOIP-RBR/UbcH5B~ubiquitin transfer complex |
| 5H7S | 2017-11-29 | 3.49 | Structural basis of the flanking zinc-finger motifs crucial for the E3 ligase activity of the LNX1 RING domain |
| 5AJ0 | 2015-05-20 | 3.5 | Cryo electron microscopy of actively translating human polysomes (POST state). |
| 3J7P | 2014-09-03 | 3.5 | Structure of the 80S mammalian ribosome bound to eEF2 |
| 6O96 | 2019-04-24 | 3.5 | Dot1L bound to the H2BK120 Ubiquitinated nucleosome |
| 6MSG | 2018-11-21 | 3.5 | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome |
| 6OLI | 2019-06-19 | 3.5 | Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule (USO1-RNC) |
| 5TGM | 2017-01-18 | 3.5 | Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro |
| 6QTZ | 2019-06-26 | 3.5 | Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles |
| 6H4H | 2019-03-27 | 3.5 | Usp28 catalytic domain variant E593D in complex with UbPA |
| 6N8O | 2019-03-13 | 3.5 | Cryo-EM structure of Rpl10-inserted (RI) pre-60S ribosomal subunit |
| 6G5I | 2018-06-06 | 3.5 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State R |
| 5JUP | 2016-10-05 | 3.5 | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure II (mid-rotated 40S subunit) |
| 6FYX | 2018-12-05 | 3.5 | Structure of a partial yeast 48S preinitiation complex with eIF5 N-terminal domain (model C1) |
| 6N8M | 2019-03-13 | 3.5 | Cryo-EM structure of pre-Lsg1 (PL) pre-60S ribosomal subunit |
| 6UH5 | 2019-11-20 | 3.5 | Structural basis of COMPASS eCM recognition of the H2Bub nucleosome |
| 2AYO | 2005-10-18 | 3.5 | Structure of USP14 bound to ubquitin aldehyde |
| 5MEI | 2017-06-28 | 3.5 | Crystal structure of Agelastatin A bound to the 80S ribosome |
| 5KHY | 2016-09-14 | 3.5 | Crystal structure of oxime-linked K6 diubiquitin |
| 5TTE | 2017-08-23 | 3.5 | Crystal Structure of an RBR E3 ubiquitin ligase in complex with an E2-Ub thioester intermediate mimic |
| 4V8P | 2014-07-09 | 3.52 | T.thermophila 60S ribosomal subunit in complex with initiation factor 6. |
| 6NQA | 2019-02-20 | 3.54 | Active state Dot1L bound to the H2B-Ubiquitinated nucleosome, 1-to-1 complex |
| 6EML | 2017-11-29 | 3.6 | Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae |
| 5LKS | 2017-04-26 | 3.6 | Structure-function insights reveal the human ribosome as a cancer target for antibiotics |
| 5T2C | 2017-01-25 | 3.6 | CryoEM structure of the human ribosome at 3.6 Angstrom resolution |
| 6UZ7 | 2020-01-15 | 3.6 | K.lactis 80S ribosome with p/PE tRNA and eIF5B |
| 6T9L | 2020-01-29 | 3.6 | SAGA DUB module bound to a ubiqitinated nucleosome |
| 4JIO | 2013-06-19 | 3.6 | Bro1 V domain and ubiquitin |
| 5IT7 | 2016-05-18 | 3.6 | Structure of the Kluyveromyces lactis 80S ribosome in complex with the cricket paralysis virus IRES and eEF2 |
| 6G18 | 2018-06-06 | 3.6 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State C |
| 5OHN | 2017-09-20 | 3.6 | Crystal structure of USP30 in covalent complex with ubiquitin propargylamide (low resolution) |
| 4UG0 | 2015-06-10 | 3.6 | STRUCTURE OF THE HUMAN 80S RIBOSOME |
| 4U4O | 2014-10-22 | 3.6 | Crystal structure of Geneticin bound to the yeast 80S ribosome |
| 6R84 | 2019-06-26 | 3.6 | Yeast Vms1 (Q295L)-60S ribosomal subunit complex (pre-state with Arb1) |
| 6G5H | 2018-06-06 | 3.6 | Cryo-EM structure of a late human pre-40S ribosomal subunit - Mature |
| 4UF6 | 2015-03-04 | 3.69 | UCH-L5 in complex with ubiquitin-propargyl bound to an activating fragment of INO80G |
| 6TTU | 2020-02-12 | 3.7 | Ubiquitin Ligation to substrate by a cullin-RING E3 ligase at 3.7A resolution: NEDD8-CUL1-RBX1 N98R-SKP1-monomeric b-TRCP1dD-IkBa-UB~UBE2D2 |
| 4NQK | 2014-03-05 | 3.7 | Structure of an Ubiquitin complex |
| 5NDW | 2017-12-13 | 3.7 | Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome |
| 6OM7 | 2019-06-19 | 3.7 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs |
| 5NDG | 2017-12-13 | 3.7 | Crystal structure of geneticin (G418) bound to the yeast 80S ribosome |
| 3J80 | 2014-11-05 | 3.75 | CryoEM structure of 40S-eIF1-eIF1A preinitiation complex |
| 6DJW | 2018-07-04 | 3.8 | Crystal Structure of pParkin (REP and RING2 deleted)-pUb-UbcH7 complex |
| 6RBE | 2019-06-26 | 3.8 | State 2 of yeast Tsr1-TAP Rps20-Deltaloop pre-40S particles |
| 5IT9 | 2016-05-18 | 3.8 | Structure of the yeast Kluyveromyces lactis small ribosomal subunit in complex with the cricket paralysis virus IRES. |
| 6NZO | 2019-08-28 | 3.8 | Set2 bound to nucleosome |
| 5MC6 | 2017-01-18 | 3.8 | Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae |
| 4DDI | 2012-02-22 | 3.8 | Crystal structure of human OTUB1/UbcH5b~Ub/Ub |
| 6N8N | 2019-03-13 | 3.8 | Cryo-EM structure of Lsg1-engaged (LE) pre-60S ribosomal subunit |
| 5OHM | 2017-10-04 | 3.8 | K33-specific affimer bound to K33 diUb |
| 4ZUX | 2016-02-24 | 3.82 | SAGA DUB module Ubp8/Sgf11/Sus1/Sgf73 bound to ubiqitinated nucleosome |
| 5CVO | 2015-10-07 | 3.88 | WDR48:USP46~ubiquitin ternary complex |
| 5GAK | 2016-02-24 | 3.88 | Yeast 60S ribosomal subunit with A-site tRNA, P-site tRNA and eIF-5A |
| 5A2Q | 2015-07-15 | 3.9 | Structure of the HCV IRES bound to the human ribosome |
| 6OLF | 2019-06-19 | 3.9 | Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs |
| 6IP5 | 2019-05-29 | 3.9 | Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii) |
| 5VO0 | 2017-12-06 | 3.9 | Structure of a TRAF6-Ubc13~Ub complex |
| 5FLX | 2015-12-23 | 3.9 | Mammalian 40S HCV-IRES complex |
| 6GQB | 2018-07-11 | 3.9 | Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GDP+AlF4/sordarin) |
| 6OA9 | 2019-07-03 | 3.9 | Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ATP |
| 6IP8 | 2019-05-29 | 3.9 | Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv) |
| 6OLZ | 2019-06-19 | 3.9 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA |
| 3J7R | 2014-09-03 | 3.9 | Structure of the translating mammalian ribosome-Sec61 complex |
| 5APN | 2015-12-16 | 3.91 | Structure of the yeast 60S ribosomal subunit in complex with Arx1, Alb1 and N-terminally tagged Rei1 |
| 5JUU | 2016-10-05 | 4.0 | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure V (least rotated 40S subunit) |
| 5JUO | 2016-10-05 | 4.0 | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure I (fully rotated 40S subunit) |
| 6T83 | 2019-12-25 | 4.0 | Structure of yeast disome (di-ribosome) stalled on poly(A) tract. |
| 6GQV | 2018-07-11 | 4.0 | Cryo-EM recosntruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP) |
| 3J81 | 2014-11-05 | 4.0 | CryoEM structure of a partial yeast 48S preinitiation complex |
| 6KIV | 2019-09-11 | 4.0 | Cryo-EM structure of human MLL1-ubNCP complex (4.0 angstrom) |
| 5JUT | 2016-10-05 | 4.0 | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure IV (almost non-rotated 40S subunit) |
| 6KIW | 2019-09-11 | 4.0 | Cryo-EM structure of human MLL3-ubNCP complex (4.0 angstrom) |
| 6OAA | 2019-07-03 | 4.1 | Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ADP-BeFx, state 1 |
| 6PX3 | 2019-08-28 | 4.1 | Set2 bound to nucleosome |
| 5ANB | 2015-10-21 | 4.1 | Mechanism of eIF6 release from the nascent 60S ribosomal subunit |
| 6J99 | 2019-02-27 | 4.1 | Cryo-EM structure of human DOT1L in complex with an H2B-monoubiquitinated nucleosome |
| 6G51 | 2018-06-06 | 4.1 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State D |
| 6EF3 | 2018-10-17 | 4.17 | Yeast 26S proteasome bound to ubiquitinated substrate (4D motor state) |
| 5T6R | 2017-02-08 | 4.2 | Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis: 60S-Nmd3 Complex |
| 5JUS | 2016-10-05 | 4.2 | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure III (mid-rotated 40S subunit) |
| 5ANC | 2015-10-21 | 4.2 | Mechanism of eIF6 release from the nascent 60S ribosomal subunit |
| 4V8Y | 2014-07-09 | 4.3 | Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex |
| 5GJQ | 2016-08-17 | 4.35 | Structure of the human 26S proteasome bound to USP14-UbAl |
| 6GQ1 | 2018-07-11 | 4.4 | Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP/sordarin) |
| 6FTX | 2018-08-08 | 4.5 | Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome |
| 6IP6 | 2019-05-29 | 4.5 | Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii) |
| 6G53 | 2018-06-06 | 4.5 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State E |
| 5KGF | 2016-07-27 | 4.54 | Structural model of 53BP1 bound to a ubiquitylated and methylated nucleosome, at 4.5 A resolution |
| 6DJX | 2018-07-04 | 4.8 | Crystal Structure of pParkin-pUb-UbcH7 complex |
| 3JAP | 2015-08-12 | 4.9 | Structure of a partial yeast 48S preinitiation complex in closed conformation |
| 4V6X | 2014-07-09 | 5.0 | Structure of the human 80S ribosome |
| 6GSM | 2019-07-31 | 5.15 | Structure of a partial yeast 48S preinitiation complex in open conformation |
| 6I7O | 2019-01-16 | 5.3 | The structure of a di-ribosome (disome) as a unit for RQC and NGD quality control pathways recognition. |
| 4V8M | 2014-07-09 | 5.57 | High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome |
| 6GSN | 2019-06-26 | 5.75 | Structure of a partial yeast 48S preinitiation complex in closed conformation |
| 4V6W | 2014-07-09 | 6.0 | Structure of the D. melanogaster 80S ribosome |
| 3JAQ | 2015-08-12 | 6.0 | Structure of a partial yeast 48S preinitiation complex in open conformation |
| 3J6X | 2014-06-11 | 6.1 | S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 5 degree rotation (Class II) |
| 3J6Y | 2014-06-11 | 6.1 | S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 2 degree rotation (Class I) |
| 3J77 | 2014-08-06 | 6.2 | Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class II - rotated ribosome with 1 tRNA) |
| 3J78 | 2014-08-06 | 6.3 | Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class I - non-rotated ribosome with 2 tRNAs) |
| 6FEC | 2018-03-14 | 6.3 | Human cap-dependent 48S pre-initiation complex |
| 5L9U | 2016-09-14 | 6.4 | Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination |
| 5L9T | 2016-10-26 | 6.4 | Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for polyubiquitination where UBE2S, APC2, and APC11 are modeled into low resolution density |
| 4V8Z | 2014-07-09 | 6.6 | Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex |
| 4ADX | 2012-02-08 | 6.6 | The Cryo-EM Structure of the Archaeal 50S Ribosomal Subunit in Complex with Initiation Factor 6 |
| 6JMA | 2019-05-15 | 6.8 | cryo-EM structure of DOT1L bound to H2B ubiquitinated nucleosome |
| 4V8T | 2014-07-09 | 8.1 | Cryo-EM Structure of the 60S Ribosomal Subunit in Complex with Arx1 and Rei1 |
| 4WHV | 2015-09-30 | 8.3 | E3 ubiquitin-protein ligase RNF8 in complex with Ubiquitin-conjugating enzyme E2 N and Polyubiquitin-B |
| 5WYJ | 2017-03-29 | 8.7 | Cryo-EM structure of the 90S small subunit pre-ribosome (Dhr1-depleted, Enp1-TAP, state 1) |
| 4V6I | 2014-07-09 | 8.8 | Localization of the small subunit ribosomal proteins into a 6.1 A cryo-EM map of Saccharomyces cerevisiae translating 80S ribosome |
| 5A5B | 2015-07-22 | 9.5 | Structure of the 26S proteasome-Ubp6 complex |
Relevant UniProtKB Entries
| Percent Identity | Matching Chains | Protein | Accession | Entry Name |
|---|---|---|---|---|
| 96.1 | Ubiquitin variant Ubv.21.4 | P63048 | RL40_BOVIN | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P63050 | RL40_CANLF | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P18101 | RL40_DROME | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P63052 | RL40_FELCA | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P62987 | RL40_HUMAN | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0C273 | RL40_MACFA | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P62984 | RL40_MOUSE | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P68205 | RL40_OPHHA | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P63053 | RL40_PIG | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0C275 | RL40_PONPY | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P62986 | RL40_RAT | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0C276 | RL40_SHEEP | |
| 96.0 | Ubiquitin variant Ubv.21.4 | P62992 | RS27A_BOVIN | |
| 96.0 | Ubiquitin variant Ubv.21.4 | P62978 | RS27A_CAVPO | |
| 96.0 | Ubiquitin variant Ubv.21.4 | P79781 | RS27A_CHICK | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P15357 | RS27A_DROME | |
| 96.0 | Ubiquitin variant Ubv.21.4 | P62979 | RS27A_HUMAN | |
| 96.0 | Ubiquitin variant Ubv.21.4 | P68200 | RS27A_ICTPU | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P29504 | RS27A_MANSE | |
| 96.0 | Ubiquitin variant Ubv.21.4 | P62983 | RS27A_MOUSE | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P68202 | RS27A_PLUXY | |
| 96.0 | Ubiquitin variant Ubv.21.4 | P62982 | RS27A_RAT | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P68203 | RS27A_SPOFR | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0CG53 | UBB_BOVIN | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0CG54 | UBB_CAVPO | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0CG62 | UBB_CHICK | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0CG67 | UBB_GORGO | |
| 96.1 | Ubiquitin variant Ubv.21.4 | Q8MKD1 | UBB_HORSE | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0CG47 | UBB_HUMAN | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0CG49 | UBB_MOUSE | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0CG65 | UBB_PANTR | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0CG60 | UBB_PONPY | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0CG51 | UBB_RAT | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0CG55 | UBB_SHEEP | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0CH28 | UBC_BOVIN | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0CG66 | UBC_GORGO | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0CG48 | UBC_HUMAN | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0CG50 | UBC_MOUSE | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0CG64 | UBC_PANTR | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0CG68 | UBC_PIG | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0CG61 | UBC_PONPY | |
| 96.1 | Ubiquitin variant Ubv.21.4 | Q63429 | UBC_RAT | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P62976 | UBIQP_CRIGR | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P0CG69 | UBIQP_DROME | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P62972 | UBIQP_XENLA | |
| 96.1 | Ubiquitin variant Ubv.21.4 | Q865C5 | UBIQ_CAMDR | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P68197 | UBIQ_CERCA | |
| 96.1 | Ubiquitin variant Ubv.21.4 | P62975 | UBIQ_RABIT | |
| 94.7 | Ubiquitin variant Ubv.21.4 | P46575 | RL40_EIMBO | |
| 94.7 | Ubiquitin variant Ubv.21.4 | P23398 | UBIQP_STRPU | |
| 94.7 | Ubiquitin variant Ubv.21.4 | Q8SWD4 | UBIQ_ENCCU | |
| 94.7 | Ubiquitin variant Ubv.21.4 | P49632 | RL40_CAEEL | |
| 94.7 | Ubiquitin variant Ubv.21.4 | P0CG71 | UBIQ1_CAEEL | |
| 94.7 | Ubiquitin variant Ubv.21.4 | P59669 | UBIQP_GEOCY | |
| 93.4 | Ubiquitin variant Ubv.21.4 | P69201 | RL40_LEIMA | |
| 93.2 | Ubiquitin variant Ubv.2.1 | P69200 | RL40_LEITA | |
| 93.4 | Ubiquitin variant Ubv.21.4 | P0CH11 | RL401_CHLRE | |
| 93.4 | Ubiquitin variant Ubv.21.4 | P0CH10 | RL403_CHLRE | |
| 93.4 | Ubiquitin variant Ubv.21.4 | P33190 | RL40_TETPY | |
| 93.4 | Ubiquitin variant Ubv.21.4 | P0DJ25 | RL40_TETTS | |
| 93.4 | Ubiquitin variant Ubv.21.4 | P0CG82 | UBIQP_TETPY | |
| 93.4 | Ubiquitin variant Ubv.21.4 | P19848 | UBIQ_COPCO | |
| 93.4 | Ubiquitin variant Ubv.21.4 | P42740 | UBIQP_AGLNE | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P59271 | R27AA_ARATH | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0CH06 | RL401_SCHPO | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0CH07 | RL402_SCHPO | |
| 92.1 | Ubiquitin variant Ubv.21.4 | B9DHA6 | RL40A_ARATH | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0CH34 | RL40A_ORYSJ | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0CH08 | RL40A_YEAST | |
| 92.1 | Ubiquitin variant Ubv.21.4 | Q42202 | RL40B_ARATH | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0CH35 | RL40B_ORYSJ | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0CH09 | RL40B_YEAST | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P51423 | RL40_BRARP | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P40909 | RL40_CRYNJ | |
| 93.4 | Ubiquitin variant Ubv.21.4 | P14794 | RL40_DICDI | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P49636 | RL40_NICSY | |
| 92.0 | Ubiquitin variant Ubv.21.4 | P69061 | RS27A_KLULA | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P62980 | RS27A_SOLLC | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P62981 | RS27A_SOLTU | |
| 92.0 | Ubiquitin variant Ubv.21.4 | P05759 | RS31_YEAST | |
| 92.1 | Ubiquitin variant Ubv.21.4 | Q9SHE7 | RUB1_ARATH | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0C073 | RUB1_DESAN | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0C030 | RUB1_ORYSJ | |
| 92.1 | Ubiquitin variant Ubv.21.4 | Q8RUC6 | RUB2_ARATH | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0C031 | RUB2_ORYSJ | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0CG73 | UBI1P_CANAX | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0CG85 | UBI1P_NICSY | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0CH04 | UBI1P_PETCR | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0CH05 | UBI2P_PETCR | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0CG74 | UBI4P_CANAX | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0CG75 | UBI4P_KLULA | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0CG84 | UBI4P_NICSY | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0CG72 | UBI4P_SCHPO | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0CG63 | UBI4P_YEAST | |
| 93.4 | Ubiquitin variant Ubv.21.4 | P0CG76 | UBIQA_DICDI | |
| 93.4 | Ubiquitin variant Ubv.21.4 | P0CG77 | UBIQD_DICDI | |
| 93.4 | Ubiquitin variant Ubv.21.4 | P0CG78 | UBIQF_DICDI | |
| 93.4 | Ubiquitin variant Ubv.21.4 | P0CG79 | UBIQG_DICDI | |
| 93.4 | Ubiquitin variant Ubv.21.4 | P0CG81 | UBIQH_DICDI | |
| 93.4 | Ubiquitin variant Ubv.21.4 | P0CG80 | UBIQI_DICDI | |
| 93.4 | Ubiquitin variant Ubv.21.4 | P0CG88 | UBIQJ_DICDI | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P69309 | UBIQP_AVEFA | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0CG83 | UBIQP_HORVU | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P69315 | UBIQP_LINUS | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P69322 | UBIQP_PEA | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P69325 | UBIQP_SOYBN | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P69310 | UBIQ_AVESA | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P69313 | UBIQ_HELAN | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P69317 | UBIQ_LUPPO | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P69326 | UBIQ_WHEAT | |
| 92.1 | Ubiquitin variant Ubv.21.4 | Q8H159 | UBQ10_ARATH | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0CH33 | UBQ11_ARATH | |
| 92.1 | Ubiquitin variant Ubv.21.4 | Q3E7T8 | UBQ14_ARATH | |
| 92.1 | Ubiquitin variant Ubv.21.4 | Q1EC66 | UBQ3_ARATH | |
| 92.1 | Ubiquitin variant Ubv.21.4 | Q58G87 | UBQ3_ORYSJ | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0CH32 | UBQ4_ARATH | |
| 91.9 | Ubiquitin variant Ubv.2.1 | P14797 | RS27A_DICDI | |
| 90.8 | Ubiquitin variant Ubv.21.4 | P0C032 | RUB3_ORYSJ | |
| 90.8 | Ubiquitin variant Ubv.21.4 | P42739 | UBIQP_ACEPE | |
| 90.8 | Ubiquitin variant Ubv.21.4 | P22589 | UBIQP_PHYIN | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0CH27 | RL402_TRYCR | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P49633 | RL40_ACACA | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0C224 | RL40_NEUCR | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P14795 | RL40_TRYCR | |
| 92.0 | Ubiquitin variant Ubv.21.4 | P14799 | RS27A_NEUCR | |
| 92.1 | Ubiquitin variant Ubv.21.4 | P0CG70 | UBI4P_NEUCR | |
| 90.8 | Ubiquitin variant Ubv.21.4 | Q3E7K8 | UBQ12_ARATH | |
| 90.8 | Ubiquitin variant Ubv.21.4 | P21899 | RL40_TRYBB | |
| 91.7 | Ubiquitin variant Ubv.2.1 | Q9ARZ9 | R27AA_ORYSJ | |
| 91.7 | Ubiquitin variant Ubv.2.1 | P59232 | R27AB_ARATH | |
| 91.7 | Ubiquitin variant Ubv.2.1 | P51431 | R27AB_ORYSJ | |
| 91.7 | Ubiquitin variant Ubv.2.1 | P59233 | R27AC_ARATH | |
| 91.7 | Ubiquitin variant Ubv.2.1 | P0CG86 | RS271_HORVU | |
| 91.7 | Ubiquitin variant Ubv.2.1 | P0CG87 | RS272_HORVU | |
| 91.7 | Ubiquitin variant Ubv.2.1 | P47905 | RS27A_LUPAL | |
| 91.7 | Ubiquitin variant Ubv.2.1 | P27923 | RS27A_MAIZE | |
| 91.7 | Ubiquitin variant Ubv.2.1 | P0C016 | RS27A_SCHPO | |
| 91.7 | Ubiquitin variant Ubv.2.1 | P0C8R3 | RS27B_SCHPO | |
| 91.4 | Ubiquitin variant Ubv.2.1 | P59272 | RS27A_DAUCA | |
| 100.0 | Ubiquitin variant Ubv.2.1 | P84589 | UBIQ_LUMTE | |
| 97.4 | Ubiquitin variant Ubv.2.1 | P31753 | RS27A_ASPOF | |
| 99.4 | Ubiquitin-specific protease 2 (USP2) | O75604 | UBP2_HUMAN | |
| 95.5 | Ubiquitin-specific protease 2 (USP2) | Q5U349 | UBP2_RAT | |
| 95.5 | Ubiquitin-specific protease 2 (USP2) | Q2KHV7 | UBP2_BOVIN | |
| 95.0 | Ubiquitin-specific protease 2 (USP2) | O88623 | UBP2_MOUSE |