The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing.


Abstract

Viral immune evasion by sequence variation is a major hindrance to HIV-1 vaccine design. To address this challenge, our group has developed a computational model, rooted in physics, that aims to predict the fitness landscape of HIV-1 proteins in order to design vaccine immunogens that lead to impaired viral fitness, thus blocking viable escape routes. Here, we advance the computational models to address previous limitations, and directly test model predictions against in vitro fitness measurements of HIV-1 strains containing multiple Gag mutations. We incorporated regularization into the model fitting procedure to address finite sampling. Further, we developed a model that accounts for the specific identity of mutant amino acids (Potts model), generalizing our previous approach (Ising model) that is unable to distinguish between different mutant amino acids. Gag mutation combinations (17 pairs, 1 triple and 25 single mutations within these) predicted to be either harmful to HIV-1 viability or fitness-neutral were introduced into HIV-1 NL4-3 by site-directed mutagenesis and replication capacities of these mutants were assayed in vitro. The predicted and measured fitness of the corresponding mutants for the original Ising model (r = -0.74, p = 3.6×10-6) are strongly correlated, and this was further strengthened in the regularized Ising model (r = -0.83, p = 3.7×10-12). Performance of the Potts model (r = -0.73, p = 9.7×10-9) was similar to that of the Ising model, indicating that the binary approximation is sufficient for capturing fitness effects of common mutants at sites of low amino acid diversity. However, we show that the Potts model is expected to improve predictive power for more variable proteins. Overall, our results support the ability of the computational models to robustly predict the relative fitness of mutant viral strains, and indicate the potential value of this approach for understanding viral immune evasion, and harnessing this knowledge for immunogen design.

Submission Details

ID: LKkeX8UC4

Submitter: Connie Wang

Submission Date: Oct. 22, 2018, 10:46 a.m.

Version: 1

Publication Details
Mann JK;Barton JP;Ferguson AL;Omarjee S;Walker BD;Chakraborty A;Ndung'u T,PLoS Comput Biol (2014) The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing. PMID:25102049
Additional Information

Study Summary

Number of data points 38
Proteins Gag-Pol polyprotein
Unique complexes 38
Assays/Quantities/Protocols Experimental Assay: Replication capacity ratio
Libraries Supplmental Table 1: Replication Capacity of Gag p24

Structure view and single mutant data analysis

Study data

No weblogo for data of varying length.
Colors: D E R H K S T N Q A V I L M F Y W C G P
 

Data Distribution

Studies with similar sequences (approximate matches)

Correlation with other assays (exact sequence matches)


Relevant PDB Entries

Structure ID Release Date Resolution Structure Title
1F6U 2000-10-09 NMR structure of the HIV-1 nucleocapsid protein bound to stem-loop sl2 of the psi-RNA packaging signal. Implications for genome recognition
2KOD 2009-11-24 A high-resolution NMR structure of the dimeric C-terminal domain of HIV-1 CA
1MFS 1998-06-17 DYNAMICAL BEHAVIOR OF THE HIV-1 NUCLEOCAPSID PROTEIN; NMR, 30 STRUCTURES
1O1W 2003-02-18 SOLUTION STRUCTURE OF THE RNASE H DOMAIN OF THE HIV-1 REVERSE TRANSCRIPTASE IN THE PRESENCE OF MAGNESIUM
2JZW 2009-01-13 How the HIV-1 nucleocapsid protein binds and destabilises the (-)primer binding site during reverse transcription
1WJA 1998-05-13 SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (D FORM), NMR, REGULARIZED MEAN STRUCTURE
2LYA 2013-02-13 Structure of HIV-1 myr(-) matrix protein in complex with 1,2-dioctanoyl-sn-phosphatidylcholine
2JPR 2007-10-09 Joint refinement of the HIV-1 CA-NTD in complex with the assembly inhibitor CAP-1
4JEC 2013-07-24 Joint neutron and X-ray structure of per-deuterated HIV-1 protease in complex with clinical inhibitor amprenavir
1IHW 1996-07-11 SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 40 STRUCTURES
2L6E 2010-12-29 NMR Structure of the monomeric mutant C-terminal domain of HIV-1 Capsid in complex with stapled peptide Inhibitor
1IHV 1996-10-14 SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, MINIMIZED AVERAGE STRUCTURE
2H3Z 2006-07-25 Structure of the HIV-1 matrix protein bound to di-C4-phosphatidylinositol-(4,5)-bisphosphate
2EXF 2007-04-24 Solution structure of the HIV-1 nucleocapsid (NCp7(12-55)) complexed with the DNA (-) Primer Binding Site
1QMC 1999-12-14 C-terminal DNA-binding domain of HIV-1 integrase, NMR, 42 structures
2LYB 2013-02-13 Structure of HIV-1 myr(-) matrix protein in complex with 1,2-dioctanoyl-sn-phosphatidyl-L-serine
1NCP 1993-10-31 STRUCTURAL CHARACTERIZATION OF A 39 RESIDUE SYNTHETIC PEPTIDE CONTAINING THE TWO ZINC BINDING DOMAINS FROM THE HIV-1 P7 NUCLEOCAPSID PROTEIN BY CD AND NMR SPECTROSCOPY
2M8P 2013-11-20 The structure of the W184AM185A mutant of the HIV-1 capsid protein
2HMX 1996-01-29 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 MATRIX PROTEIN
2JYG 2008-02-26 Solution Structure of the W184A/M185A Mutant of the Carboxy-terminal Dimerization Domain of the HIV-1 Capsid Protein
1TAM 1996-07-11 HUMAN IMMUNODEFICIENCY VIRUS, NMR, MINIMIZED AVERAGE STRUCTURE
2C55 2005-11-02 Solution Structure of the Human Immunodeficiency Virus Type 1 p6 Protein
2JYL 2008-02-12 Solution Structure of A Double Mutant of The Carboxy-terminal Dimerization Domain of The HIV-1 Capsid Protein
2M8N 2013-11-20 HIV-1 capsid monomer structure
1WJE 1998-12-16 SOLUTION STRUCTURE OF H12C MUTANT OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE COMPLEXED TO CADMIUM, NMR, MINIMIZED AVERAGE STRUCTURE
1WJF 1998-12-16 SOLUTION STRUCTURE OF H12C MUTANT OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE COMPLEXED TO CADMIUM, NMR, 40 STRUCTURES
2LF4 2011-11-09 Structure of a monomeric mutant of the HIV-1 capsid protein
3DIK 2008-09-16 Pseudo-atomic model of the HIV-1 CA hexameric lattice
2M8L 2013-11-20 HIV capsid dimer structure
1WJD 1998-05-13 SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (E FORM), NMR, 38 STRUCTURES
5E5K 2016-05-04 Joint X-ray/neutron structure of HIV-1 protease triple mutant (V32I,I47V,V82I) with darunavir at pH 4.3
1WJC 1998-05-13 SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (E FORM), NMR, REGULARIZED MEAN STRUCTURE
1UPH 2004-01-08 HIV-1 Myristoylated Matrix
1ESK 2000-04-26 SOLUTION STRUCTURE OF NCP7 FROM HIV-1
5IRT 2016-06-22 Dimerization interface of the noncrystalline HIV-1 capsid protein lattice from solid state NMR spectroscopy of tubular assemblies
1BVE 1996-08-17 HIV-1 PROTEASE-DMP323 COMPLEX IN SOLUTION, NMR, 28 STRUCTURES
2L46 2011-12-14 C-terminal zinc finger of the HIVNCp7 with platinated DNA
1BVG 1996-08-17 HIV-1 PROTEASE-DMP323 COMPLEX IN SOLUTION, NMR MINIMIZED AVERAGE STRUCTURE
5T82 2017-01-18 HIV-1 reverse transcriptase thumb subdomain
2L4L 2010-12-08 Structural insights into the cTAR DNA recognition by the HIV-1 Nucleocapsid protein: role of sugar deoxyriboses in the binding polarity of NC
1Q9P 2004-03-02 Solution structure of the mature HIV-1 protease monomer
2H3V 2006-07-25 Structure of the HIV-1 Matrix protein bound to di-C8-phosphatidylinositol-(4,5)-bisphosphate
2H3Q 2006-07-25 Solution structure of HIV-1 myrMA bound to di-C4-phosphatidylinositol-(4,5)-bisphosphate
2H3I 2006-07-25 Solution structure of the HIV-1 myristoylated Matrix protein
2L45 2011-12-14 C-terminal zinc knuckle of the HIVNCp7 with DNA
1WJB 1998-05-13 SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (D FORM), NMR, 40 STRUCTURES
1GWP 2002-06-21 STRUCTURE OF THE N-TERMINAL DOMAIN OF THE MATURE HIV-1 CAPSID PROTEIN
2H3F 2006-07-25 Solution structure of the HIV-1 MA protein
1AAF 1994-01-31 NUCLEOCAPSID ZINC FINGERS DETECTED IN RETROVIRUSES: EXAFS STUDIES ON INTACT VIRUSES AND THE SOLUTION-STATE STRUCTURE OF THE NUCLEOCAPSID PROTEIN FROM HIV-1
2M3Z 2013-02-27 NMR solution structure of HIV-1 nucleocapsid protein in complex with an inhibitor displaying a 2 inhibitors:1 NC stoichiometry
5YOK 2018-07-18 0.85 Structure of HIV-1 Protease in Complex with Inhibitor KNI-1657
3A2O 2010-03-02 0.88 Crystal Structure of HIV-1 Protease Complexed with KNI-1689
3FX5 2009-03-24 0.93 Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by High Resolution X-ray Crystallography
3DJK 2008-09-30 1.0 Wild Type HIV-1 Protease with potent Antiviral inhibitor GRL-0255A
3NU3 2010-08-25 1.02 Wild Type HIV-1 Protease with Antiviral Drug Amprenavir
1NH0 2004-04-13 1.03 1.03 A structure of HIV-1 protease: inhibitor binding inside and outside the active site
3NDX 2011-07-20 1.03 HIV-1 Protease Saquinavir:Ritonavir 1:50 complex structure
2J9J 2007-08-28 1.04 Atomic-resolution Crystal Structure of Chemically-Synthesized HIV-1 Protease Complexed with Inhibitor JG-365
3D20 2008-05-27 1.05 Crystal structure of HIV-1 mutant I54V and inhibitor DARUNAVIA
3D1Y 2008-05-27 1.05 Crystal structure of HIV-1 mutant I54V and inhibitor SAQUINA
3D1X 2008-06-03 1.05 Crystal structure of HIV-1 mutant I54M and inhibitor saquinavir
3BVA 2008-04-01 1.05 Cystal structure of HIV-1 Active Site Mutant D25N and p2-NC analog inhibitor
4HE9 2013-08-21 1.06 Crystal Structure of HIV-1 protease mutants I54M complexed with inhibitor GRL-0519
3DK1 2009-05-12 1.07 Wild Type HIV-1 Protease with potent Antiviral inhibitor GRL-0105A
2JE4 2007-08-28 1.07 Atomic-resolution crystal structure of chemically-synthesized HIV-1 protease in complex with JG-365
1KZK 2002-04-03 1.09 JE-2147-HIV Protease Complex
2AVS 2006-01-24 1.1 kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, and G73S
4EJD 2013-05-01 1.1 HIV Protease (PR) dimer in closed form with pepstatin in active site and fragment 1F1 in the outside/top of flap
2AVO 2006-01-24 1.1 Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S
2AVM 2006-01-24 1.1 Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S
2AOG 2006-01-17 1.1 Crystal structure analysis of HIV-1 protease mutant V82A with a substrate analog P2-NC
2QD7 2008-04-22 1.11 HIV-1 Protease Mutant V82A with potent Antiviral inhibitor GRL-98065
4ZIP 2015-07-15 1.11 HIV-1 wild Type protease with GRL-0648A (a isophthalamide-derived P2-Ligand)
3TOH 2012-08-15 1.12 HIV-1 Protease - Epoxydic Inhibitor Complex (pH 9 - Orthorombic Crystal form P212121)
3DS4 2008-09-02 1.12 HIV-1 capsid C-terminal domain mutant (L211S) in complex with an inhibitor of particle assembly (CAI)
6DV4 2018-10-31 1.14 HIV-1 wild type protease with GRL-04315A, a tetrahydronaphthalene carboxamide with (R)-Boc-amine and (S)-hydroxyl functionalities as the P2 ligand
3NDW 2011-07-20 1.14 HIV-1 Protease Saquinavir:Ritonavir 1:15 complex structure
5JG1 2016-09-21 1.16 HIV-1 wild Type protease with GRL-031-14A (a Adamantane P1-Ligand with tetrahydropyrano-tetrahydrofuran in P2 and isobutylamine in P1')
3NU6 2010-08-25 1.16 Crystal Structure of HIV-1 Protease Mutant I54M with Antiviral Drug Amprenavir
3I6O 2009-09-29 1.17 Crystal structure of wild type HIV-1 protease with macrocyclic inhibitor GRL-0216A
4MC9 2014-04-02 1.19 HIV protease in complex with AA74
1K1T 2002-07-10 1.2 Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
3NU4 2010-08-25 1.2 Crystal Structure of HIV-1 Protease Mutant V32I with Antiviral Drug Amprenavir
3CYX 2008-05-27 1.2 Crystal structure of HIV-1 mutant I50V and inhibitor saquinavira
3DS2 2008-09-02 1.2 HIV-1 capsid C-terminal domain mutant (Y169A)
1T3R 2005-05-03 1.2 HIV protease wild-type in complex with TMC114 inhibitor
5AGZ 2015-05-06 1.2 Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
4FL8 2012-10-17 1.2 HIV-1 protease complexed with gem-diol-amine tetrahedral intermediate
6DIF 2018-10-17 1.2 Wild-type HIV-1 protease in complex with tipranavir
6DV0 2018-10-31 1.2 HIV-1 wild type protease with GRL-02815A, a thiochroman heterocycle with (S)-Boc-amine functionality as the P2 ligand
2QCI 2008-04-22 1.2 HIV-1 Protease mutant D30N with potent Antiviral inhibitor GRL-98065
2J9K 2007-08-28 1.2 Atomic-resolution Crystal Structure of Chemically-Synthesized HIV-1 Protease Complexed with Inhibitor MVT-101
6E9A 2018-11-07 1.22 HIV-1 WILD TYPE PROTEASE WITH GRL-034-17A, (3aS, 5R, 6aR)-2-OXOHEXAHYD CYCLOPENTA[D]-5-OXAZOLYL URETHANE WITH A BICYCLIC OXAZOLIDINONE SCAFF AS THE P2 LIGAND
2F8G 2006-03-07 1.22 HIV-1 protease mutant I50V complexed with inhibitor TMC114
5DGU 2015-10-28 1.22 Crystal Structure of HIV-1 Protease Inhibitors Containing Substituted fused-Tetrahydropyranyl Tetrahydrofuran as P2-Ligand GRL-004-11A
4HDP 2013-08-14 1.22 Crystal Structure of HIV-1 protease mutants I50V complexed with inhibitor GRL-0519
4DFG 2012-03-21 1.23 Crystal Structure of Wild-type HIV-1 Protease with Cyclopentyltetrahydro- furanyl Urethanes as P2-ligand, GRL-0249A
3TOG 2012-08-15 1.24 HIV-1 Protease - Epoxydic Inhibitor Complex (pH 9 - Monoclinic Crystal form P21)
2F81 2006-03-07 1.25 HIV-1 Protease mutant L90M complexed with inhibitor TMC114
3VF5 2012-11-21 1.25 Crystal Structure of HIV-1 Protease Mutant I47V with novel P1'-Ligands GRL-02031
1SDU 2004-05-25 1.25 Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site.
3NDU 2011-07-20 1.25 HIV-1 Protease Saquinavir:Ritonavir 1:5 complex structure
6DJ1 2018-10-17 1.26 Wild-type HIV-1 protease in complex with Lopinavir
5AH8 2015-05-06 1.26 Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
5UPZ 2017-05-10 1.27 HIV-1 wild Type protease with GRL-0518A , an isophthalamide-derived P2-P3 ligand with the para-hydoxymethyl sulfonamide isostere as the P2' group
3OK9 2010-09-22 1.27 Crystal structure of wild-type HIV-1 protease with new oxatricyclic designed inhibitor GRL-0519A
2QD6 2008-04-22 1.28 HIV-1 Protease Mutant I50V with potent Antiviral inhibitor GRL-98065
5BS4 2015-09-09 1.29 HIV-1 wild Type protease with GRL-047-11A (a methylamine bis-Tetrahydrofuran P2-Ligand, 4-amino sulfonamide derivative)
3NU5 2010-08-25 1.29 Crystal Structure of HIV-1 Protease Mutant I50V with Antiviral Drug Amprenavir
4HDF 2013-08-14 1.29 Crystal Structure of HIV-1 protease mutants V82A complexed with inhibitor GRL-0519
3H5B 2009-06-16 1.29 Crystal structure of wild type HIV-1 protease with novel P1'-ligand GRL-02031
1SDT 2004-05-25 1.3 Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site.
3KFR 2010-02-23 1.3 HIV Protease (PR) dimer with inhibitor TL-3 bound and fragment 1F1 in the outside/top of flap
4DQE 2012-03-07 1.3 Crystal Structure of (G16C/L38C) HIV-1 Protease in Complex with DRV
2IEN 2006-10-03 1.3 Crystal structure analysis of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017)
3HAW 2011-04-27 1.3 Crystal structure of [L-Ala51/51']HIV-1 protease with reduced isostere MVT-101 inhibitor
3HAU 2011-04-27 1.3 Crystal structure of chemically synthesized HIV-1 protease with reduced isostere MVT-101 inhibitor
4YHQ 2015-06-10 1.3 Crystal structure of multidrug resistant clinical isolate PR20 with GRL-5010A
2AOC 2006-01-17 1.3 Crystal structure analysis of HIV-1 protease mutant I84V with a substrate analog P2-NC
3VF7 2012-11-21 1.3 Crystal Structure of HIV-1 Protease Mutant L76V with novel P1'-Ligands GRL-02031
6E7J 2018-11-07 1.3 HIV-1 wild type protease with GRL-042-17A, 3-phenylhexahydro-2h-cyclopenta[d]oxazol-2-one with a bicyclic oxazolidinone scaffold as the P2 ligand
3BVB 2008-04-01 1.3 Cystal structure of HIV-1 Active Site Mutant D25N and inhibitor Darunavir
2A1E 2006-02-21 1.3 High resolution structure of HIV-1 PR with TS-126
3D1Z 2008-05-27 1.3 Crystal structure of HIV-1 mutant I54M and inhibitor DARUNAVIR
2AVQ 2006-01-24 1.3 Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S
4U8W 2014-11-05 1.3 HIV-1 wild Type protease with GRL-050-10A (a Gem-difluoro-bis-Tetrahydrofuran as P2-Ligand)
4MC6 2014-04-02 1.31 HIV protease in complex with SA499
4J55 2013-05-15 1.31 Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical isolate PR20 with the potent antiviral inhibitor GRL-02031
6DJ7 2018-10-17 1.31 HIV-1 protease with mutation L76V in complex with GRL-5010 (gem-difluoro-bis-tetrahydrofuran as P2 ligand)
4FLG 2012-10-17 1.31 HIV-1 protease mutant I47V complexed with reaction intermediate
2AOF 2006-01-17 1.32 Crystal structure analysis of HIV-1 Protease mutant V82A with a substrate analog P1-P6
3TL9 2012-04-25 1.32 crystal structure of HIV protease model precursor/Saquinavir complex
2O4L 2006-12-12 1.33 Crystal Structure of HIV-1 Protease (Q7K, I50V) in Complex with Tipranavir
5UOV 2017-05-10 1.33 HIV-1 wild Type protease with GRL-1118A , an isophthalamide-derived P2-P3 ligand with the sulfonamide isostere as the P2' group
5BRY 2015-09-09 1.34 HIV-1 wild Type protease with GRL-011-11A (a methylamine bis-Tetrahydrofuran P2-Ligand, sulfonamide isostere derivate)
3TH9 2011-09-28 1.34 Crystal Structure of HIV-1 Protease Mutant Q7K V32I L63I with a cyclic sulfonamide inhibitor
2BB9 2005-11-15 1.35 Structure of HIV1 protease and AKC4p_133a complex.
5AHA 2015-05-06 1.35 Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
2QD8 2008-04-22 1.35 HIV-1 Protease Mutant I84V with potent Antiviral inhibitor GRL-98065
4YE3 2015-06-10 1.35 Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 with Inhibitor GRL-4410A
1T7I 2005-05-10 1.35 The structural and thermodynamic basis for the binding of TMC114, a next-generation HIV-1 protease inhibitor.
3NUO 2010-08-25 1.35 Crystal Structure of HIV-1 Protease Mutant L90M with Antiviral Drug Amprenavir
3TKG 2012-04-25 1.36 crystal structure of HIV model protease precursor/saquinavir complex
6DJ2 2018-10-17 1.36 HIV-1 protease with single mutation L76V in complex with Lopinavir
4U7V 2015-03-25 1.38 Structure of wild-type HIV protease in complex with degraded photosensitive inhibitor
3UCB 2012-03-28 1.38 Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Darunavir
3QN8 2012-02-08 1.38 HIV-1 protease (mutant Q7K L33I L63I) in complex with a novel inhibitor
4U1J 2015-04-08 1.38 HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential HIV-1 escape through identical epitopes
3K4V 2010-06-09 1.39 New crystal form of HIV-1 Protease/Saquinavir structure reveals carbamylation of N-terminal proline
4MC1 2014-04-02 1.39 HIV protease in complex with SA526P
3QIH 2012-02-01 1.39 HIV-1 protease (mutant Q7K L33I L63I) in complex with a novel inhibitor
3CYW 2008-05-27 1.4 Effect of Flap Mutations on Structure of HIV-1 Protease and Inhibition by Saquinavir and Darunavir
3QAA 2011-12-21 1.4 HIV-1 wild type protease with a substituted bis-Tetrahydrofuran inhibitor, GRL-044-10A
4FM6 2012-10-17 1.4 HIV-1 protease mutant V32I complexed with reaction intermediate
1SDV 2004-05-25 1.4 Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site.
3KA2 2011-04-27 1.4 Crystal structure of chemically synthesized 203 amino acid 'covalent dimer' [L-Ala;Gly51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.4 A resolution
2XDE 2010-12-22 1.4 Crystal structure of the complex of PF-3450074 with an engineered HIV capsid N terminal domain
3QIO 2011-04-20 1.4 Crystal Structure of HIV-1 RNase H with engineered E. coli loop and N-hydroxy quinazolinedione inhibitor
2AOD 2006-01-17 1.4 Crystal structure analysis of HIV-1 protease with a substrate analog P2-NC
2AOI 2006-01-17 1.4 Crystal structure analysis of HIV-1 protease with a substrate analog P1-P6
2QNP 2008-04-15 1.41 HIV-1 Protease in complex with a iodo decorated pyrrolidine-based inhibitor
2AOH 2006-01-17 1.42 Crystal structure analysis of HIV-1 Protease mutant V82A with a substrate analog P6-PR
3VFA 2012-11-21 1.43 Crystal Structure of HIV-1 Protease Mutant V82A with novel P1'-Ligands GRL-02031
5AH9 2015-05-06 1.44 Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
2FNT 2006-09-05 1.44 Crystal structure of a drug-resistant (V82A) inactive (D25N) HIV-1 protease complexed with AP2V variant of HIV-1 NC-p1 substrate.
3NYG 2011-11-02 1.45 X-ray structure of ester chemical analogue [O-Gly51,O-Gly51']HIV-1 protease complexed with MVT-101 inhibitor
3WNF 2013-12-25 1.45 Cyclic hexapeptide CKIDNC in complex with HIV-1 integrase
3UFN 2012-03-28 1.45 Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Saquinavir
2F80 2006-03-07 1.45 HIV-1 Protease mutant D30N complexed with inhibitor TMC114
3QP0 2012-02-15 1.45 HIV-1 protease (mutant Q7K L33I L63I) in complex with a novel inhibitor
3QBF 2012-01-18 1.45 HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor
3PWR 2011-04-20 1.45 HIV-1 Protease Mutant L76V complexed with Saquinavir
3TOF 2012-08-15 1.45 HIV-1 Protease - Epoxydic Inhibitor Complex (pH 6 - Orthorombic Crystal form P212121)
3O9I 2011-08-10 1.45 Crystal Structure of wild-type HIV-1 Protease in complex with af61
3ST5 2011-08-17 1.45 Crystal structure of wild-type HIV-1 protease with C3-Substituted Hexahydrocyclopentafuranyl Urethane as P2-Ligand, GRL-0489A
3PWM 2011-04-20 1.46 HIV-1 Protease Mutant L76V with Darunavir
3B7V 2007-12-18 1.46 HIV-1 protease complexed with gem-diol-amine tetrahedral intermediate NLLTQI
6B3F 2018-01-03 1.46 Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,5S)-5-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide
4HEG 2013-08-21 1.46 Crystal Structure of HIV-1 protease mutants R8Q complexed with inhibitor GRL-0519
6MCR 2019-04-24 1.48 X-ray crystal structure of wild type HIV-1 protease in complex with GRL-001
6B38 2018-01-03 1.48 Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,6R)-6-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide
6DIL 2018-10-17 1.48 HIV-1 protease with single mutation L76V in complex with tipranavir
2QNN 2008-04-15 1.48 HIV-1 protease in complex with a multiple decorated pyrrolidine-based inhibitor
4HDB 2013-08-14 1.49 Crystal Structure of HIV-1 protease mutants D30N complexed with inhibitor GRL-0519
5JFP 2016-09-21 1.49 HIV-1 wild Type protease with GRL-097-13A (a Adamantane P1-Ligand with bis-THF in P2 and isobutylamine in P1')
1XL2 2005-06-07 1.5 HIV-1 Protease in complex with pyrrolidinmethanamine
3NWQ 2011-11-02 1.5 X-ray structure of ester chemical analogue [O-Ile50,O-Ile50']HIV-1 protease complexed with MVT-101
5AHB 2015-05-06 1.5 Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
4Q1Y 2015-02-18 1.5 Mutations Outside the Active Site of HIV-1 Protease Alter Enzyme Structure and Dynamic Ensemble of the Active Site to Confer Drug Resistance
2PWR 2008-04-15 1.5 HIV-1 protease in complex with a carbamoyl decorated pyrrolidine-based inhibitor
5AHC 2015-05-06 1.5 Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
6B3G 2018-01-03 1.5 Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,6S)-6-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide
5YOJ 2018-07-11 1.5 Structure of A17 HIV-1 Protease in Complex with Inhibitor KNI-1657
3NUJ 2010-08-25 1.5 Crystal Structure of HIV-1 Protease Mutant I54V with Antiviral Drug Amprenavir
2FGV 2006-11-07 1.5 X-ray crystal structure of HIV-1 Protease T80N variant in complex with the inhibitor saquinavir used to explore the role of invariant Thr80 in HIV-1 protease structure, function, and viral infectivity.
4NX4 2014-02-26 1.5 Re-refinement of CAP-1 HIV-CA complex
2AVV 2006-01-24 1.5 Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, and G73S
3B80 2007-12-18 1.5 HIV-1 protease mutant I54V complexed with gem-diol-amine intermediate NLLTQI
5AH6 2015-05-06 1.5 Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
4QJ6 2014-10-29 1.5 Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with p1-p6 substrate variant (L449F)
4DQB 2012-03-07 1.5 Crystal Structure of wild-type HIV-1 Protease in Complex with DRV
4A6C 2012-05-09 1.5 Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based HIV-1 Protease Inhibitors
3WNH 2013-12-25 1.5 Cyclic hexapeptide PKZDNv in complex with HIV-1 integrase
4G1Q 2013-02-06 1.51 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with Rilpivirine (TMC278, Edurant), a non-nucleoside rt-inhibiting drug
6MCS 2019-04-24 1.52 X-ray crystal structure of wild type HIV-1 protease in complex with GRL-003
5ULT 2017-05-03 1.53 HIV-1 wild Type protease with GRL-100-13A (a Crown-like Oxotricyclic Core as the P2-Ligand with the sulfonamide isostere as the P2' group)
4ZLS 2015-07-15 1.53 HIV-1 wild Type protease with GRL-096-13A (a Boc-derivative P2-Ligand, 3,-5-dimethylbiphenyl P1-Ligand)
3ZPT 2013-11-06 1.54 Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors
2AOE 2006-01-17 1.54 crystal structure analysis of HIV-1 protease mutant V82A with a substrate analog CA-P2
2O4S 2006-12-12 1.54 Crystal Structure of HIV-1 Protease (Q7K) in Complex with Lopinavir
4QJA 2014-10-29 1.54 Crystal structure of inactive HIV-1 protease in complex with p1-p6 substrate variant (P453L)
4E43 2012-05-30 1.54 HIV protease (PR) dimer with acetate in exo site and peptide in active site
5AH7 2015-02-18 1.55 Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
1K1U 2002-07-10 1.55 Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
3TKW 2012-04-25 1.55 Crystal structure of HIV protease model precursor/Darunavir complex
1DAZ 2000-05-03 1.55 Structural and kinetic analysis of drug resistant mutants of HIV-1 protease
4CPS 2014-12-17 1.55 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
3ZPS 2013-11-06 1.55 Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors
3VFB 2012-11-21 1.55 Crystal Structure of HIV-1 Protease Mutant N88D with novel P1'-Ligands GRL-02031
2PQZ 2008-04-15 1.55 HIV-1 Protease in complex with a pyrrolidine-based inhibitor
4J54 2013-05-15 1.55 Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical isolate PR20 with the potent antiviral inhibitor GRL-0519A
4MC2 2014-04-02 1.56 HIV protease in complex with SA525P
2R43 2008-09-09 1.58 I50V HIV-1 protease in complex with an amino decorated pyrrolidine-based inhibitor
4U1H 2015-04-08 1.59 HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential HIV-1 escape through identical epitopes
4COC 2014-06-04 1.59 HIV-1 capsid C-terminal domain mutant (Y169L)
3QRS 2012-02-22 1.59 HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor
1EXQ 2000-11-03 1.6 CRYSTAL STRUCTURE OF THE HIV-1 INTEGRASE CATALYTIC CORE DOMAIN
3EKW 2009-09-01 1.6 Crystal structure of the inhibitor Atazanavir (ATV) in complex with a multi-drug resistance HIV-1 protease variant (L10I/G48V/I54V/V64I/V82A) Refer: FLAP+ in citation.
3HLO 2011-07-27 1.6 Crystal structure of chemically synthesized 'covalent dimer' [Gly51/D-Ala51']HIV-1 protease
3OU4 2011-03-30 1.6 MDR769 HIV-1 protease complexed with TF/PR hepta-peptide
3OUB 2011-03-30 1.6 MDR769 HIV-1 protease complexed with NC/p1 hepta-peptide
4G9D 2013-03-20 1.6 Crystal Structure of HLA B2705-KK10
3JVY 2009-12-08 1.6 HIV-1 Protease Mutant G86A with DARUNAVIR
3BXS 2008-03-25 1.6 Crystal Structures Of Highly Constrained Substrate And Hydrolysis Products Bound To HIV-1 Protease. Implications For Catalytic Mechanism
3FSM 2010-01-05 1.6 CRYSTAL STRUCTURE OF A CHEMICALLY SYNTHESIZED 203 AMINO ACID 'COVALENT DIMER' [L-Ala51,D-Ala51'] HIV-1 PROTEASE MOLECULE
3BXR 2008-03-25 1.6 Crystal Structures Of Highly Constrained Substrate And Hydrolysis Products Bound To HIV-1 Protease. Implications For Catalytic Mechanism
4G8I 2013-03-20 1.6 Crystal Structure of HLA B2705-KK10-L6M
3EL9 2009-09-01 1.6 Crystal structure of atazanavir (ATV) in complex with a multidrug HIV-1 protease (V82T/I84V)
3DS1 2008-09-02 1.6 HIV-1 capsid C-terminal domain mutant (E187A) in complex with an inhibitor of particle assembly (CAI)
2AOJ 2006-01-17 1.6 Crystal structure analysis of HIV-1 protease with a substrate analog P6-PR
3EL5 2009-09-01 1.6 Crystal structure of nelfinavir (NFV) complexed with a multidrug variant (ACT) (V82T/I84V) of HIV-1 protease
6B3C 2018-01-03 1.6 Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,6R)-6-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide
2Z4O 2008-04-22 1.6 Wild Type HIV-1 Protease with potent Antiviral inhibitor GRL-98065
3DS0 2008-09-02 1.6 HIV-1 capsid C-terminal domain mutant (N183A) in complex with an inhibitor of particle assembly (CAI)
2O4K 2006-12-12 1.6 Crystal Structure of HIV-1 Protease (Q7K) in Complex with Atazanavir
6C8X 2018-12-05 1.61 Wild-type HIV-1 protease in complex with a phenylboronic acid (P2') analog of darunavir
3QPJ 2012-02-15 1.61 HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor
3IAW 2011-04-27 1.61 Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution
3QRO 2012-02-22 1.62 HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor
6B3H 2018-01-03 1.62 Crystal Structure of HIV Protease complexed with N-(2-(2-((6R,9S)-2,2-dioxido-2-thia-1,7-diazabicyclo[4.3.1]decan-9-yl)ethyl)-3-fluorophenyl)-3,3-bis(4-fluorophenyl)propanamide
5DGW 2015-10-28 1.62 Crystal Structure of HIV-1 Protease Inhibitor GRL-105-11A Containing Substituted fused-Tetrahydropyranyl Tetrahydrofuran as P2-Ligand
3UF3 2012-03-28 1.63 Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical isolate PR20
6B36 2018-01-03 1.63 Crystal Structure of HIV Protease complexed with (S)-N-(3-fluoro-2-(2-(1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide
4IPY 2013-10-16 1.64 HIV capsid C-terminal domain
1ZPK 2006-04-25 1.65 Crystal structure of the complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
2ZGA 2009-02-03 1.65 HIV-1 protease in complex with a dimethylallyl decorated pyrrolidine based inhibitor (hexagonal space group)
2NPH 2006-12-19 1.65 Crystal structure of HIV1 protease in situ product complex
3OXX 2011-09-28 1.65 Crystal Structure of HIV-1 I50V, A71V Protease in Complex with the Protease Inhibitor Atazanavir
5UFZ 2018-01-10 1.65 HIV-1 Protease complexed with Inhibitor: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2S)-1-(1-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}cyclopropyl)-1-hydroxy-3-phenylpropan-2-yl]carbamate
3O9G 2011-08-10 1.65 Crystal Structure of wild-type HIV-1 Protease in complex with af53
2XXM 2011-10-12 1.65 Crystal structure of the HIV-1 capsid protein C-terminal domain in complex with a camelid VHH and the CAI peptide.
3KT2 2010-02-16 1.65 Crystal Structure of N88D mutant HIV-1 Protease
3CKT 2009-03-24 1.65 HIV-1 protease in complex with a dimethylallyl decorated pyrrolidine based inhibitor (orthorombic space group)
4OBK 2014-11-26 1.65 Crystal structure of inactive HIV-1 protease in complex with the P1-P6 substrate variant (L449F/S451N)
3KDB 2010-03-02 1.66 Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10006
4QJ7 2014-10-29 1.67 Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with p1-p6 substrate variant (R452S)
6BZ2 2018-02-28 1.67 Crystal structure of wild-type HIV-1 protease with a novel HIV-1 inhibitor GRL-14213A of 6-5-5-ring fused crown-like tetrahydropyranofuran as the P2-ligand, a cyclopropylaminobenzothiazole as the P2'-ligand and 3,5-difluorophenylmethyl as the P1-ligand
4OBF 2014-11-26 1.68 Crystal Structure of Nelfinavir-Resistant, Inactive HIV-1 Protease Variant (D30N/N88D) in Complex with the p1-p6 substrate variant (S451N)
4EPJ 2012-06-06 1.69 Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate p2-NC
2WHH 2009-12-01 1.69 HIV-1 protease tethered dimer Q-product complex along with nucleophilic water molecule
2BBB 2005-11-15 1.7 Structure of HIV1 protease and hh1_173_3a complex.
3O9H 2011-08-10 1.7 Crystal Structure of wild-type HIV-1 Protease in complex with kd26
1B9F 1999-07-19 1.7 MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY
3OTS 2011-03-30 1.7 MDR769 HIV-1 protease complexed with MA/CA hepta-peptide
4F75 2013-05-15 1.7 Crystal Structure of active HIV-1 Protease in Complex with the N terminal product of the substrate RH-IN
3AVI 2012-02-15 1.7 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
1A8O 1998-10-14 1.7 HIV CAPSID C-TERMINAL DOMAIN
3NLS 2011-09-07 1.7 Crystal Structure of HIV-1 Protease in Complex with KNI-10772
1FFI 2001-06-01 1.7 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
3AVG 2012-01-18 1.7 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
4E91 2012-04-25 1.7 Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BD3
5JFU 2016-09-21 1.7 HIV-1 wild Type protease with GRL-007-14A (a Adamantane P1-Ligand with bis-THF in P2 and benzylamine in P1')
3I7E 2009-09-29 1.7 Co-crystal structure of HIV-1 protease bound to a mutant resistant inhibitor UIC-98038
1B9D 1999-07-19 1.7 MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY
4AH9 2012-12-19 1.7 Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification
3AVA 2012-01-18 1.7 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
1K2B 2002-07-10 1.7 Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
5JPA 2016-08-10 1.7 Hexameric HIV-1 CA H12Y mutant
3AVJ 2012-01-18 1.7 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
4U7Q 2015-03-25 1.7 Structure of wild-type HIV protease in complex with photosensitive inhibitor PDI-6
3O9F 2011-08-10 1.7 Crystal Structure of wild-type HIV-1 Protease in complex with kd27
3OU3 2011-03-30 1.7 MDR769 HIV-1 protease complexed with PR/RT hepta-peptide
3WNE 2013-12-25 1.7 Cyclic hexapeptide PKIDNG in complex with HIV-1 integrase
4CPT 2014-12-17 1.7 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
3I8W 2009-12-01 1.7 Crystal structure of a metallacarborane inhibitor bound to HIV protease
3OUA 2011-03-30 1.7 MDR769 HIV-1 protease complexed with p1/p6 hepta-peptide
4EQ0 2012-06-06 1.7 Crystal Structure of inactive single chain variant of HIV-1 Protease in Complex with the substrate p2-NC
5XOS 2017-06-14 1.7 Crystal structure of HLA-B35 in complex with a pepetide antigen
3AV9 2012-01-18 1.7 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
3QIN 2011-04-20 1.7 Crystal Structure of HIV-1 RNase H p15 with engineered E. coli loop and pyrimidinol carboxylic acid inhibitor
3AVF 2012-01-18 1.7 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
4CPW 2014-12-17 1.7 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
2WKZ 2009-12-15 1.7 HIV-1 Protease Inhibitors Containing a Tertiary Alcohol in the Transition-State Mimic with Improved Cell-Based Antiviral Activity
1DIF 1996-03-08 1.7 HIV-1 PROTEASE IN COMPLEX WITH A DIFLUOROKETONE CONTAINING INHIBITOR A79285
3EL1 2009-09-01 1.7 Crystal Structure of wild-type HIV protease in complex with the inhibitor, Atazanavir
3OQD 2011-04-06 1.71 Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants
3HBO 2010-05-26 1.71 Crystal structure of chemically synthesized [D-Ala51/51']HIV-1 protease
3OQ7 2011-04-06 1.71 Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants
4QAG 2014-06-04 1.71 Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNASE H domain of HIV-1 reverse transcriptase
3NDT 2011-07-20 1.72 HIV-1 Protease Saquinavir:Ritonavir 1:1 complex structure
3QRM 2012-02-22 1.73 HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor
1XL5 2005-06-07 1.73 HIV-1 Protease in complex with amidhyroxysulfone
4AHS 2012-12-19 1.75 Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification
4OBJ 2014-11-26 1.75 Crystal Structure of Inactive HIV-1 Protease in Complex with the p1-p6 substrate variant (S451N)
1B6L 2000-01-07 1.75 HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 4
5HRN 2016-12-14 1.75 HIV Integrase Catalytic Domain containing F185K mutation complexed with GSK0002
6DJ5 2018-10-17 1.75 HIV-1 protease with mutation L76V in complex with GRL-0519 (tris-tetrahydrofuran as P2 ligand)
1D4L 2000-10-11 1.75 HIV-1 PROTEASE COMPLEXED WITH A MACROCYCLIC PEPTIDOMIMETIC INHIBITOR
3OTY 2011-03-30 1.75 MDR769 HIV-1 protease complexed with RT/RH hepta-peptide
2UXZ 2008-05-20 1.75 Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary- Alcohol-Containing Transition-State Mimic
3EKV 2009-09-01 1.75 Crystal structure of the wild type HIV-1 protease with the inhibitor, Amprenavir
4I8Z 2013-07-24 1.75 Crystal structure of wild type HIV-1 protease in complex with non-peptidic inhibitor, GRL008
3OXV 2011-09-28 1.75 Crystal Structure of HIV-1 I50V, A71 Protease in Complex with the protease inhibitor amprenavir.
3AVK 2012-01-18 1.75 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
3WNG 2013-12-25 1.75 Cyclic hexapeptide PKIDNp in complex with HIV-1 integrase
3BHE 2008-12-09 1.75 HIV-1 protease in complex with a three armed pyrrolidine derivative
1MTR 1996-08-01 1.75 HIV-1 PROTEASE COMPLEXED WITH A CYCLIC PHE-ILE-VAL PEPTIDOMIMETIC INHIBITOR
5YRS 2018-03-07 1.76 X-ray Snapshot of HIV-1 Protease in Action: Observation of Tetrahedral Intermediate and Its SIHB with Catalytic Aspartate
3OY4 2011-02-09 1.76 Crystal Structure of HIV-1 L76V Protease in Complex with the Protease Inhibitor Darunavir.
5JL4 2017-10-04 1.76 Inhibitor resistant mutant catalytic core domain of HIV-1 Integrase
2UY0 2008-05-20 1.76 Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary- Alcohol-Containing Transition-State Mimic
3KFP 2010-02-23 1.77 HIV Protease (PR) with inhibitor TL-3 bound, and DMSOs in exo site
3KFN 2010-02-23 1.77 HIV Protease (PR) with inhibitor TL-3 and fragment hit 4D9 by soaking
4U0C 2014-11-12 1.77 Hexameric HIV-1 CA in complex with Nup153 peptide, P6 crystal form
3AVC 2012-01-18 1.77 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
2PWC 2008-04-15 1.78 HIV-1 protease in complex with a amino decorated pyrrolidine-based inhibitor
4OBG 2014-11-26 1.78 Crystal Structure of Nelfinavir-Resistant, Inactive HIV-1 Protease (D30N/N88D) in Complex with the p1-p6 substrate.
1FEJ 2001-06-01 1.78 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
1EC0 2002-06-26 1.79 HIV-1 protease in complex with the inhibitor bea403
4DQH 2012-03-07 1.79 Crystal Structure of (R14C/E65C) HIV-1 Protease in complex with DRV
4EJK 2013-05-01 1.79 HIV Protease (PR) dimer in closed form with pepstatin in active site and fragment 1F1-N in the outside/top of flap
4Q5M 2015-04-08 1.79 D30N tethered HIV-1 protease dimer/saquinavir complex
4GB2 2013-07-31 1.79 HIV-1 protease (mutant Q7K L33I L63I) in complex with a bicyclic pyrrolidine inhibitor
3HDK 2010-04-28 1.8 Crystal structure of chemically synthesized [Aib51/51']HIV-1 protease
1HVL 1994-04-30 1.8 INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE
3NXN 2011-11-02 1.8 X-ray structure of ester chemical analogue 'covalent dimer' [Ile50,O-Ile50']HIV-1 protease complexed with KVS-1 inhibitor
2XYF 2011-12-07 1.8 HIV-1 Inhibitors with a Tertiary-Alcohol-containing Transition-State Mimic and various P2 and P1 prime Substituents
3GI0 2011-08-10 1.8 Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [l-ala51,d-ala51'] hiv-1 protease molecule complexed with jg-365 inhibitor
4ICL 2013-02-06 1.8 HIV-1 reverse transcriptase with bound fragment at the incoming dNTP binding site
1HVH 1998-12-30 1.8 NONPEPTIDE CYCLIC CYANOGUANIDINES AS HIV PROTEASE INHIBITORS
4CP7 2014-12-10 1.8 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
1EC3 2002-06-26 1.8 HIV-1 protease in complex with the inhibitor MSA367
4J5J 2013-05-15 1.8 Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Amprenavir
1HVK 1994-04-30 1.8 INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE
4EQJ 2012-06-06 1.8 Crystal Structure of inactive single chain variant of HIV-1 Protease in Complex with the substrate RT-RH
3ZPU 2013-11-06 1.8 Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors
1QBU 1997-10-15 1.8 HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
2R3T 2008-09-02 1.8 I50V HIV-1 protease mutant in complex with a carbamoyl decorated pyrrolidine-based inhibitor
3AO2 2011-03-16 1.8 Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase
2QI4 2008-04-22 1.8 Crystal structure of protease inhibitor, MIT-2-AD93 in complex with wild type HIV-1 protease
4A6B 2012-05-09 1.8 Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based HIV-1 Protease Inhibitors
3NF7 2011-04-27 1.8 Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design
1FG6 2001-06-01 1.8 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
3JW2 2009-12-08 1.8 HIV-1 Protease Mutant G86S with DARUNAVIR
4K4R 2013-09-18 1.8 TL-3 inhibited Trp6Ala HIV Protease with 1-bromo-2-napthoic acid bound in exosite
3GI5 2010-03-09 1.8 Crystal structure of protease inhibitor, KB62 in complex with wild type HIV-1 protease
1BWB 1998-09-30 1.8 HIV-1 PROTEASE (V82F/I84V) DOUBLE MUTANT COMPLEXED WITH SD146 OF DUPONT PHARMACEUTICALS
2FXE 2007-02-20 1.8 X-ray crystal structure of HIV-1 protease CRM mutant complexed with atazanavir (BMS-232632)
1G35 2001-06-06 1.8 CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR, AHA024
3OU1 2011-03-30 1.8 MDR769 HIV-1 protease complexed with RH/IN hepta-peptide
1HXW 1998-02-04 1.8 HIV-1 PROTEASE DIMER COMPLEXED WITH A-84538
3KF0 2010-02-23 1.8 HIV Protease with fragment 4D9 bound
1FGL 1997-04-01 1.8 Cyclophilin A complexed with a fragment of HIV-1 GAG protein
4K4Q 2013-09-18 1.8 TL-3 inhibited Trp6Ala HIV Protease with 3-bromo-2,6-dimethoxybenzoic acid bound in flap site
3KFS 2010-02-23 1.8 HIV Protease (PR) dimer with inhibitor TL-3 bound and fragment 2F4 in the outside/top of flap
1W5W 2004-12-22 1.8 HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor
4CPR 2014-12-17 1.8 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
3GGU 2009-08-11 1.8 HIV PR drug resistant patient's variant in complex with darunavir
1HWR 1999-03-23 1.8 MOLECULAR RECOGNITION OF CYCLIC UREA HIV PROTEASE INHIBITORS
1QBR 1997-10-15 1.8 HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
4AHV 2012-12-19 1.8 Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification
4E92 2012-04-25 1.8 Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BM4
3BGC 2008-09-02 1.8 HIV-1 protease in complex with a benzyl decorated oligoamine
3JVW 2009-12-08 1.8 HIV-1 Protease Mutant G86A with symmetric inhibitor DMP323
1PRO 1996-08-17 1.8 HIV-1 PROTEASE DIMER COMPLEXED WITH A-98881
1HVR 1995-01-26 1.8 RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS
1QBS 1997-10-15 1.8 HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
3KT5 2010-02-16 1.8 Crystal Structure of N88S mutant HIV-1 Protease
3EKY 2009-09-01 1.8 Crystal Structure of wild-type HIV protease in complex with the inhibitor, Atazanavir
2ZD1 2008-02-12 1.8 Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with TMC278 (Rilpivirine), A Non-nucleoside RT Inhibitor
3KDD 2010-03-02 1.8 Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10265
5VCK 2018-04-18 1.8 HIV Protease (PR) with TL-3 in the active site and (Z)-N-(thiazol-2-yl)-N'-tosylcarbamimidate in the exosite
6AOC 2018-08-08 1.8 Crystal Structure of an N-Hydroxythienopyrimidine-2,4-dione RNase H Active Site Inhibitor with Multiple Binding Modes to HIV Reverse Transcriptase
1W5V 2004-12-01 1.8 HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor
4AHT 2012-12-19 1.8 Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification
3OUD 2011-03-30 1.8 MDR769 HIV-1 protease complexed with CA/p2 hepta-peptide
5KAO 2016-08-31 1.8 Crystal structure of wild type HIV-1 protease in complex with GRL-10413
1SP5 2005-07-19 1.8 Crystal structure of HIV-1 protease complexed with a product of autoproteolysis
1D4J 2002-06-26 1.81 HIV-1 protease in complex with the inhibitor MSL370
1D4H 2002-06-26 1.81 HIV-1 Protease in complex with the inhibitor BEA435
5HRP 2016-12-14 1.81 HIV Integrase Catalytic Domain containing F185K + A124T mutations complexed with GSK0002
1D4I 2002-06-26 1.81 HIV-1 protease in complex with the inhibitor BEA425
4EP3 2012-06-06 1.81 Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate CA-p2
1EBW 2002-06-26 1.81 HIV-1 protease in complex with the inhibitor BEA322
2R38 2008-09-02 1.81 I84V HIV-1 protease mutant in complex with a carbamoyl decorated pyrrolidine-based inhibitor
4OJR 2014-06-11 1.82 Crystal Structure of the HIV-1 Integrase catalytic domain with GSK1264
3BC4 2008-09-02 1.82 I84V HIV-1 protease in complex with a pyrrolidine diester
4CPU 2014-12-17 1.82 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
4QJ9 2014-10-29 1.83 Crystal structure of inactive HIV-1 protease in complex with p1-p6 substrate variant (R452S)
1IIQ 2002-04-12 1.83 CRYSTAL STRUCTURE OF HIV-1 PROTEASE COMPLEXED WITH A HYDROXYETHYLAMINE PEPTIDOMIMETIC INHIBITOR
3GI6 2010-03-09 1.84 Crystal structure of protease inhibitor, AD78 in complex with wild type HIV-1 protease
5TC2 2018-04-04 1.84 C-terminal domain of HIV-1 integrase, crystal structure
4OBH 2014-11-26 1.85 Crystal Structure of Inactive HIV-1 Protease in Complex with the p1-p6 substrate variant (L449F)
3AVB 2012-01-18 1.85 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
2QI7 2008-04-22 1.85 Crystal structure of protease inhibitor, MIT-2-AD86 in complex with wild type HIV-1 protease
2QI6 2008-04-22 1.85 Crystal structure of protease inhibitor, MIT-2-KB98 in complex with wild type HIV-1 protease
1D4K 2000-10-11 1.85 HIV-1 PROTEASE COMPLEXED WITH A MACROCYCLIC PEPTIDOMIMETIC INHIBITOR
3DLK 2008-10-07 1.85 Crystal Structure of an engineered form of the HIV-1 Reverse Transcriptase, RT69A
4F76 2013-05-15 1.85 Crystal Structure of the active HIV-1 Protease in Complex with the products of p1-p6 substrate
2PYN 2008-02-26 1.85 HIV-1 PR mutant in complex with nelfinavir
6D0D 2019-05-01 1.85 X-ray crystal structure of wild type HIV-1 protease in complex with GRL-087-13
2QI5 2008-04-22 1.85 Crystal structure of protease inhibitor, MIT-2-KC08 in complex with wild type HIV-1 protease
1B6J 2000-01-07 1.85 HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 1
2QHY 2008-04-22 1.85 Crystal Structure of protease inhibitor, MIT-1-AC86 in complex with wild type HIV-1 protease
1B6K 2000-01-07 1.85 HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 5
3MXE 2010-11-10 1.85 Crystal structure of HIV-1 protease inhibitor, KC32 complexed with wild-type protease
2FNS 2006-09-05 1.85 Crystal structure of wild-type inactive (D25N) HIV-1 protease complexed with wild-type HIV-1 NC-p1 substrate.
1FF0 2001-06-01 1.85 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES.
4Q1W 2015-02-18 1.85 Mutations Outside the Active Site of HIV-1 Protease Alter Enzyme Structure and Dynamic Ensemble of the Active Site to Confer Drug Resistance
4COP 2014-06-04 1.85 HIV-1 capsid C-terminal domain mutant (Y169S)
1FG8 2001-06-01 1.85 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
4CPX 2014-12-17 1.85 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
2QHZ 2008-04-22 1.85 Crystal structure of protease inhibitor, MIT-1-AC87 in complex with wild type HIV-1 protease
3GI4 2010-03-09 1.85 Crystal structure of protease inhibitor, KB60 in complex with wild type HIV-1 protease
1B6M 2000-01-07 1.85 HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 6
1Z1R 2005-03-22 1.85 HIV-1 protease complexed with Macrocyclic peptidomimetic inhibitor 2
1Z1H 2005-03-22 1.85 HIV-1 protease complexed with macrocyclic peptidomimetic inhibitor 3
3NU9 2010-08-25 1.85 Crystal Structure of HIV-1 Protease Mutant I84V with Antiviral Drug Amprenavir
4KFB 2013-05-15 1.85 HIV-1 reverse transcriptase with bound fragment at NNRTI adjacent site
5HRS 2016-12-14 1.86 HIV Integrase Catalytic Domain containing F185K + A124N + T125A mutations complexed with GSK0002
4ID1 2013-05-01 1.87 HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor
3AVM 2012-01-18 1.88 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
1DW6 2000-07-26 1.88 Structural and kinetic analysis of drug resistant mutants of HIV-1 protease
5HRR 2016-12-14 1.88 HIV Integrase Catalytic Domain containing F185K + A124N + T125S mutations complexed with GSK0002
3AVL 2012-01-18 1.88 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
3AVH 2012-01-18 1.88 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
2XV6 2011-10-12 1.89 Crystal structure of the HIV-1 capsid protein C-terminal domain (146- 220) in complex with a camelid VHH.
3MGE 2010-07-21 1.9 X-ray Structure of Hexameric HIV-1 CA
6ES8 2018-08-15 1.9 HIV capsid hexamer with IP6 ligand
1FGC 2001-06-01 1.9 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
4AHR 2012-12-19 1.9 Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification
2AID 1997-10-15 1.9 STRUCTURE OF A NON-PEPTIDE INHIBITOR COMPLEXED WITH HIV-1 PROTEASE: DEVELOPING A CYCLE OF STRUCTURE-BASED DRUG DESIGN
2GON 2006-09-26 1.9 Xray Structure of Gag133-278
3NF8 2011-04-27 1.9 Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design
3NF6 2011-04-27 1.9 Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design
4QGI 2014-07-16 1.9 X-ray crystal structure of HIV-1 protease variant G48T/L89M in complex with Saquinavir
3H47 2009-06-23 1.9 X-ray Structure of Hexameric HIV-1 CA
5TSX 2017-11-08 1.9 HIV-1 CA hexamer with NUP153 peptide - P1 crystal form
2ZYE 2009-03-24 1.9 Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by Neutron Crystallography
1MT7 2003-01-07 1.9 Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
1MES 1998-04-15 1.9 HIV-1 MUTANT (I84V) PROTEASE COMPLEXED WITH DMP323
3R4B 2011-09-21 1.9 Crystal Structure of Wild-type HIV-1 Protease in Complex With TMC310911
1HPV 1995-03-31 1.9 CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH VX-478, A POTENT AND ORALLY BIOAVAILABLE INHIBITOR OF THE ENZYME
2PYM 2008-02-26 1.9 HIV-1 PR mutant in complex with nelfinavir
4E1M 2012-04-25 1.9 Crystal Structure of HIV-1 Integrase with a non-catayltic site inhibitor
1MEU 1998-04-15 1.9 HIV-1 MUTANT (V82F, I84V) PROTEASE COMPLEXED WITH DMP323
2BPY 1999-02-23 1.9 HIV-1 protease-inhibitor complex
1SGU 2004-10-05 1.9 Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease
1M9D 2003-05-27 1.9 X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) O-type chimera Complex.
2PWM 2007-09-25 1.9 Crystal Structure of HIV-1 CA146 A92E real cell
2WL0 2009-12-15 1.9 HIV-1 Protease Inhibitors Containing a Tertiary Alcohol in the Transition-State Mimic with Improved Cell-Based Antiviral Activity
4F73 2013-05-15 1.9 Crystal Structure of active HIV-1 Protease in Complex with the N terminal product of CA-p2 cleavage site
1FFF 2001-06-01 1.9 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE : HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES.
4AHU 2012-12-19 1.9 Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification
4NYF 2014-06-25 1.9 HIV integrase in complex with inhibitor
1W5X 2004-12-22 1.9 HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor
4OBD 2014-11-26 1.9 Crystal Structure of Nelfinavir-Resistant, Inactive HIV-1 Protease (D30N/N88D) in Complex with the p1-p6 substrate variant (L449F/S451N)
6C0O 2018-08-01 1.9 Crystal structure of HIV-1 K103N mutant reverse transcriptase in complex with non-nucleoside inhibitor 25a
4EP2 2012-06-06 1.9 Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate RT-RH
4Q1X 2015-02-18 1.9 Mutations Outside the Active Site of HIV-1 Protease Alter Enzyme Structure and Dynamic Ensemble of the Active Site to Confer Drug Resistance
1W5Y 2004-10-07 1.9 HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor
1MET 1998-04-15 1.9 HIV-1 MUTANT (V82F) PROTEASE COMPLEXED WITH DMP323
1G6L 2000-11-15 1.9 1.9A CRYSTAL STRUCTURE OF TETHERED HIV-1 PROTEASE
4DGA 2012-02-08 1.9 TRIMCyp cyclophilin domain from Macaca mulatta: HIV-1 CA(O-loop) complex
1BWA 1998-10-30 1.9 HIV-1 PROTEASE (V82F/I84V) DOUBLE MUTANT COMPLEXED WITH XV638 OF DUPONT PHARMACEUTICALS
5HGN 2016-08-10 1.9 Hexameric HIV-1 CA, apo form
3BGB 2008-09-02 1.9 HIV-1 protease in complex with a isobutyl decorated oligoamine
4DQF 2012-03-07 1.9 Crystal Structure of (G16A/L38A) HIV-1 Protease in Complex with DRV
3NWX 2011-11-02 1.9 X-ray structure of ester chemical analogue [O-Ile50,O-Ile50']HIV-1 protease complexed with KVS-1 inhibitor
1MER 1998-04-15 1.9 HIV-1 MUTANT (I84V) PROTEASE COMPLEXED WITH DMP450
2BPV 1999-02-23 1.9 HIV-1 protease-inhibitor complex
6BJ3 2018-07-25 1.9 TCR55 in complex with HIV(Pol448-456)/HLA-B35
4G9F 2013-03-20 1.9 Crystal Structure of C12C TCR-HLAB2705-KK10-L6M
4U1I 2015-04-08 1.92 HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential HIV-1 escape through identical epitopes
6C0J 2018-08-01 1.92 Crystal structure of HIV-1 reverse transcriptase in complex with non-nucleoside inhibitor K-5a2
2R3W 2008-09-02 1.92 I84V HIV-1 protease in complex with a amino decorated pyrrolidine-based inhibitor
1ZJ7 2006-05-09 1.93 Crystal structure of a complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[S-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
6C8Y 2018-12-05 1.94 D30N HIV-1 protease in complex with a phenylboronic acid (P2') analog of darunavir
6CGF 2018-08-01 1.94 Crystal structure of HIV-1 Y188L mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2
4DQC 2012-03-07 1.94 Crystal Structure of (G16C/L38C) HIV-1 Protease in Complex with DRV
5HGP 2016-10-19 1.95 Hexameric HIV-1 CA in complex with hexacarboxybenzene
4XRQ 2015-07-15 1.95 Disulfide stabilized HIV-1 CA hexamer 4mut (S41A, Q67H, V165I, L172I) in complex with PF-3450074
2QI3 2008-04-22 1.95 Crystal structure of protease inhibitor, MIT-2-AD94 in complex with wild type HIV-1 protease
1G2K 2001-06-01 1.95 HIV-1 PROTEASE WITH CYCLIC SULFAMIDE INHIBITOR, AHA047
4HLA 2013-07-24 1.95 Crystal structure of wild type HIV-1 protease in complex with darunavir
4LQW 2013-08-14 1.95 Crystal structure of HIV-1 capsid N-terminal domain in complex with NUP358 cyclophilin
3OXW 2011-09-28 1.95 Crystal Structure of HIV-1 I50V, A71V Protease in Complex with the Protease Inhibitor Darunavir
6C0L 2018-08-01 1.95 Crystal structure of HIV-1 E138K mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2
2X2D 2010-03-23 1.95 acetyl-CypA:HIV-1 N-term capsid domain complex
3MXD 2010-11-10 1.95 Crystal structure of HIV-1 protease inhibitor KC53 in complex with wild-type protease
1BIS 1998-08-19 1.95 HIV-1 INTEGRASE CORE DOMAIN
4ID5 2013-02-06 1.95 HIV-1 reverse transcriptase with bound fragment at the RNase H primer grip site
4KO0 2013-08-14 1.95 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH an anilinylpyrimidine derivative (JLJ-135)
4IG3 2013-02-06 1.95 HIV-1 reverse transcriptase with bound fragment near Knuckles site
3NF9 2011-04-27 1.95 Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design
3NFA 2011-04-27 1.95 Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design
6D0E 2019-05-01 1.95 X-ray crystal structure of wild type HIV-1 protease in complex with GRL-084-13
1BIZ 1998-08-19 1.95 HIV-1 INTEGRASE CORE DOMAIN
4I8W 2013-07-24 1.96 Crystal structure of wild type HIV-1 protease in complex with non-peptidic inhibitor, GRL007
6C0K 2018-08-01 1.96 Crystal structure of HIV-1 K103N mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2
6DUF 2018-08-01 1.96 Crystal structure of HIV-1 reverse transcriptase V106A/F227L mutant in complex with non-nucleoside inhibitor 25a
3EKX 2009-09-01 1.97 Crystal structure of the wild-type HIV-1 protease with the inhibitor, Nelfinavir
3EKT 2009-09-01 1.97 Crystal Structure of the inhibitor Darunavir (DRV) in complex with a multi-drug resistant HIV-1 protease variant (L10F/G48V/I54V/V64I/V82A) (Refer: FLAP+ in citation.)
1D4Y 1999-10-13 1.97 HIV-1 PROTEASE TRIPLE MUTANT/TIPRANAVIR COMPLEX
1ZSF 2006-04-25 1.98 Crystal Structure of Complex of a Hydroxyethylamine Inhibitor with HIV-1 Protease at 2.0A Resolution
6BHS 2018-08-01 1.98 HIV-1 CA hexamer in complex with IP6, hexagonal crystal form
3LRY 2010-03-09 1.98 Crystal structure of synthetic HIV-1 capsid C-terminal domain (CCA)
1K6V 2002-02-06 2.0 LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE
1BV9 1998-09-30 2.0 HIV-1 PROTEASE (I84V) COMPLEXED WITH XV638 OF DUPONT PHARMACEUTICALS
5HGO 2016-08-10 2.0 Hexameric HIV-1 CA R18G mutant
5T6Z 2017-03-01 2.0 KIR3DL1 in complex with HLA-B*57:01-TW10
1NPW 2003-02-04 2.0 Crystal structure of HIV protease complexed with LGZ479
1F7A 2001-06-27 2.0 HOW DOES A SYMMETRIC DIMER RECOGNIZE AN ASYMMETRIC SUBSTRATE? A SUBSTRATE COMPLEX OF HIV-1 PROTEASE.
1KJG 2002-03-06 2.0 SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES
1KJF 2002-03-06 2.0 SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES
1DMP 1997-11-12 2.0 STRUCTURE OF HIV-1 PROTEASE COMPLEX
3DOX 2008-09-09 2.0 X-ray structure of HIV-1 protease in situ product complex
3EL4 2009-09-01 2.0 Crystal structure of inhibitor saquinavir (SQV) complexed with the multidrug HIV-1 protease variant L63P/V82T/I84V
4QJ8 2014-10-29 2.0 Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with p1-p6 substrate variant (P453L)
1KJ7 2002-03-06 2.0 SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES
5V5L 2017-06-14 2.0 Crystal structure of HLA-B*5801 complex with HIV-1 gag derived peptide TW10
1AJX 1997-09-17 2.0 HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC UREA INHIBITOR AHA001
1KJH 2002-03-06 2.0 SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES
5VJ3 2018-04-18 2.0 HIV Protease (PR) in open form with Mg2+ in active site and HIVE-9 in eye site
1A94 1999-01-13 2.0 STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES
6C0N 2018-08-01 2.0 Crystal structure of HIV-1 reverse transcriptase in complex with non-nucleoside inhibitor 25a
5HVP 1991-10-15 2.0 CRYSTALLOGRAPHIC ANALYSIS OF A COMPLEX BETWEEN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AND ACETYL-PEPSTATIN AT 2.0-ANGSTROMS RESOLUTION
1B6P 2000-01-07 2.0 HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 7
1NPV 2003-02-04 2.0 Crystal structure of HIV-1 protease complexed with LDC271
1BV7 1998-09-30 2.0 COUNTERACTING HIV-1 PROTEASE DRUG RESISTANCE: STRUCTURAL ANALYSIS OF MUTANT PROTEASES COMPLEXED WITH XV638 AND SD146, CYCLIC UREA AMIDES WITH BROAD SPECIFICITIES
1HIV 1993-10-31 2.0 CRYSTAL STRUCTURE OF A COMPLEX OF HIV-1 PROTEASE WITH A DIHYDROETHYLENE-CONTAINING INHIBITOR: COMPARISONS WITH MOLECULAR MODELING
1ODY 1999-02-16 2.0 HIV-1 PROTEASE COMPLEXED WITH AN INHIBITOR LP-130
1MT9 2003-01-07 2.0 Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
3TLH 1998-12-09 2.0 STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITHAN EFFICIENT INHIBITOR OF FIV PR
6DUH 2018-08-01 2.0 Crystal structure of HIV-1 reverse transcriptase Y181I mutant in complex with non-nucleoside inhibitor 25a
2FGU 2006-11-07 2.0 X-ray crystal structure of HIV-1 Protease T80S variant in complex with the inhibitor saquinavir used to explore the role of invariant Thr80 in HIV-1 protease structure, function, and viral infectivity.
1RL8 2005-04-19 2.0 Crystal structure of the complex of resistant strain of hiv-1 protease(v82a mutant) with ritonavir
1A8K 1999-01-13 2.0 CRYSTALLOGRAPHIC ANALYSIS OF HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEASE WITH AN ANALOG OF THE CONSERVED CA-P2 SUBSTRATE: INTERACTIONS WITH FREQUENTLY OCCURRING GLUTAMIC ACID RESIDUE AT P2' POSITION OF SUBSTRATES
2Q3K 2007-08-21 2.0 Crystal Structure of Lysine Sulfonamide Inhibitor Reveals the Displacement of the Conserved Flap Water Molecule in HIV-1 Protease
1ZBG 2006-04-18 2.0 Crystal structure of a complex of mutant hiv-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
4QNB 2014-12-31 2.0 Disulfide stabilized HIV-1 CA hexamer in complex with PHENYL-L-PHENYLALANINAMIDE inhibitor
1AJV 1997-08-20 2.0 HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006
1MRX 2003-11-04 2.0 Structure of HIV protease (Mutant Q7K L33I L63I V82F I84V ) complexed with KNI-577
7UPJ 1997-04-21 2.0 HIV-1 PROTEASE/U101935 COMPLEX
3EL0 2009-09-01 2.0 Crystal structure of the inhibitor Nelfinavir (NFV) in complex with a multi-drug resistant HIV-1 protease variant (L10I/G48V/I54V/V64I/V82A) (Refer: FLAP+ in citation)
1NPA 2004-01-27 2.0 crystal structure of HIV-1 protease-hup
1HSG 1996-04-03 2.0 CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES
6H09 2018-08-15 2.0 HIV capsid hexamer with IP6 ligand
5VEA 2018-04-25 2.0 HIV Protease (PR) with TL-3 in active site and 4-methylbenzene-1,2-diamine in exosite
2NXD 2007-09-18 2.0 Structure of HIV-1 protease D25N complexed with rt-rh analogue peptide GLY-ALA-ASP-ILE-PHE*TYR-LEU-ASP-GLY-ALA
1MRW 2003-11-04 2.0 Structure of HIV protease (Mutant Q7K L33I L63I) complexed with KNI-577
2O4N 2006-12-12 2.0 Crystal Structure of HIV-1 Protease (TRM Mutant) in Complex with Tipranavir
4FE6 2012-07-18 2.0 Crystal Structure of HIV-1 Protease in Complex with an enamino-oxindole inhibitor
1HVJ 1994-04-30 2.0 INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE
1HPX 1996-03-08 2.0 HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR KNI-272
6B2K 2018-09-26 2.0 E45A/R132T mutant of HIV-1 capsid protein
3OUC 2011-03-30 2.0 MDR769 HIV-1 protease complexed with p2/NC hepta-peptide
1EC2 2002-06-26 2.0 HIV-1 protease in complex with the inhibitor BEA428
2XYE 2011-12-07 2.0 HIV-1 Inhibitors with a Tertiary-Alcohol-containing Transition-State Mimic and various P2 and P1 prime Substituents
1BL3 1998-09-30 2.0 CATALYTIC DOMAIN OF HIV-1 INTEGRASE
4JMU 2013-10-30 2.0 Crystal structure of HIV matrix residues 1-111 in complex with inhibitor
1HTG 1994-07-31 2.0 X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE
1TSQ 2005-03-29 2.0 CRYSTAL STRUCTURE OF AP2V SUBSTRATE VARIANT OF NC-P1 DECAMER PEPTIDE IN COMPLEX WITH V82A/D25N HIV-1 PROTEASE MUTANT
2NXL 2007-09-18 2.0 Structure of HIV-1 protease D25N complexed with the rt-rh analogue peptide GLY-ALA-GLU-VAL-PHE*TYR-VAL-ASP-GLY-ALA
2AZ8 2006-02-28 2.0 HIV-1 Protease NL4-3 in complex with inhibitor, TL-3
4E1N 2012-04-25 2.0 Crystal Structure of HIV-1 Integrase with a non-catayltic site inhibitor
1MSM 2003-11-04 2.0 The HIV protease (mutant Q7K L33I L63I) complexed with KNI-764 (an inhibitor)
6CPN 2018-06-06 2.0 Crystal structure of DR11 presenting the RQ13 peptide
2QI1 2008-04-22 2.0 Crystal structure of protease inhibitor, MIT-1-KK81 in complex with wild type HIV-1 protease
2AQU 2006-08-29 2.0 Structure of HIV-1 protease bound to atazanavir
1A30 1998-04-29 2.0 HIV-1 PROTEASE COMPLEXED WITH A TRIPEPTIDE INHIBITOR
1AXA 1998-04-15 2.0 ACTIVE-SITE MOBILITY IN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AS DEMONSTRATED BY CRYSTAL STRUCTURE OF A28S MUTANT
1ODX 1997-04-01 2.0 HIV-1 Proteinase mutant A71T, V82A
1MSN 2003-11-04 2.0 The HIV protease (mutant Q7K L33I L63I V82F I84V) complexed with KNI-764 (an inhibitor)
6EX9 2018-06-06 2.01 Crystal Structure of HIV-1 Integrase Catalytic Core Domain with Inhibitor Peptide
2AZC 2006-02-28 2.01 HIV-1 Protease NL4-3 6X mutant
1EBZ 2002-06-26 2.01 HIV-1 protease in complex with the inhibitor BEA388
3DPH 2008-09-02 2.01 HIV-1 capsid C-terminal domain mutant (L211S)
4XRO 2015-07-15 2.01 Disulfide stabilized HIV-1 CA hexamer 4mut (S41A, Q67H, V165I, L172I)
1B92 1999-07-19 2.02 MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY
1ZPA 2005-05-31 2.02 HIV Protease with Scripps AB-3 Inhibitor
2B4J 2005-10-25 2.02 Structural basis for the recognition between HIV-1 integrase and LEDGF/p75
2AZB 2006-02-28 2.03 HIV-1 Protease NL4-3 3X mutant in complex with inhibitor, TL-3
4U0E 2014-11-12 2.04 Hexameric HIV-1 CA in complex with PF3450074
5HGM 2016-08-10 2.04 Hexameric HIV-1 CA in complex with dATP
3K2P 2010-02-09 2.04 HIV-1 Reverse Transcriptase Isolated RnaseH Domain with the Inhibitor beta-thujaplicinol Bound at the Active Site
4IFV 2013-02-06 2.05 Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-Ray Crystallographic Fragment Screening
5TEO 2017-09-27 2.05 Dimer of HIV-1 Gag CTD-SP1 fragment
1CPI 1996-03-08 2.05 REGIOSELECTIVE STRUCTURAL AND FUNCTIONAL MIMICRY OF PEPTIDES. DESIGN OF HYDROLYTICALLY STABLE CYCLIC PEPTIDOMIMETIC INHIBITORS OF HIV-1 PROTEASE
4U0A 2014-11-12 2.05 Hexameric HIV-1 CA in complex with CPSF6 peptide, P6 crystal form
4O0J 2014-07-02 2.05 HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[4-(4-chlorophenyl)-6-(3,4-dimethylphenyl)-2,5-dimethylpyridin-3-yl]ethanoic acid
6C0P 2018-08-01 2.05 Crystal structure of HIV-1 E138K mutant reverse transcriptase in complex with non-nucleoside inhibitor 25a
3U7S 2012-01-18 2.05 HIV PR drug resistant patient's variant in complex with darunavir
6C0R 2018-08-01 2.05 Crystal structure of HIV-1 K103N/Y181C mutant reverse transcriptase in complex with non-nucleoside inhibitor 25a
1ZSR 2006-04-25 2.06 Crystal structure of wild type HIV-1 protease (BRU isolate) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[S-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
1EBK 2000-07-26 2.06 Structural and kinetic analysis of drug resistant mutants of HIV-1 protease
3PSU 2011-12-07 2.07 HIV-1 protease in complex with an isobutyl decorated oligoamine (symmetric binding mode)
4JLH 2013-05-01 2.09 HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor
3QIP 2011-04-20 2.09 Structure of HIV-1 reverse transcriptase in complex with an RNase H inhibitor and nevirapine
5W4O 2018-06-20 2.09 Structure of the R18A mutant of the HIV-1 capsid protein
1LV1 2002-06-19 2.1 Crystal Structure Analysis of the non-active site mutant of tethered HIV-1 protease to 2.1A resolution
3AVN 2012-01-18 2.1 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
4IFY 2013-02-06 2.1 HIV-1 reverse transcriptase with bound fragment at the Knuckles site
1TSU 2005-03-29 2.1 CRYSTAL STRUCTURE OF DECAMER NCP1 SUBSTRATE PEPTIDE IN COMPLEX WITH WILD-TYPE D25N HIV-1 PROTEASE VARIANT
1QBT 1997-10-15 2.1 HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
3BGR 2008-02-12 2.1 Crystal structure of K103N/Y181C mutant HIV-1 reverse transcriptase (RT) in complex with TMC278 (Rilpivirine), a non-nucleoside RT inhibitor
2QI0 2008-04-22 2.1 Crystal structure of protease inhibitor, MIT-1-KK80 in complex with wild type HIV-1 protease
5T70 2017-03-01 2.1 KIR3DL1 in complex with HLA-B*57:01 presenting TSNLQEQIGW
4FAF 2012-08-29 2.1 Substrate CA/p2 in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant
2X4U 2010-03-02 2.1 Crystal structure of MHC CLass I HLA-A2.1 bound to HIV-1 Peptide RT468-476
1ODW 1997-04-01 2.1 Native HIV-1 Proteinase
5CYM 2015-12-30 2.1 HIV-1 reverse transcriptase complexed with 4-iodopyrazole
1T7K 2004-10-05 2.1 Crystal Structure of HIV Protease complexed with Arylsulfonamide azacyclic urea
1EC1 2002-06-26 2.1 HIV-1 protease in complex with the inhibitor BEA409
1QS4 1999-11-17 2.1 Core domain of HIV-1 integrase complexed with Mg++ and 1-(5-chloroindol-3-yl)-3-hydroxy-3-(2H-tetrazol-5-yl)-propenone
4PHV 1993-10-31 2.1 X-RAY CRYSTAL STRUCTURE OF THE HIV PROTEASE COMPLEX WITH L-700,417, AN INHIBITOR WITH PSEUDO C2 SYMMETRY
3EM4 2009-09-01 2.1 Crystal structure of atazanavir (ATV) in complex with I50L/A71V drug-resistant HIV-1 protease
3EM6 2009-09-01 2.1 Crystal structure of I50L/A71V mutant of hiv-1 protease in complex with inhibitor darunavir
4IDK 2013-02-06 2.1 HIV-1 reverse transcriptase with bound fragment at the 428 site
3T3C 2012-06-20 2.1 Structure of HIV PR resistant patient derived mutant (comprising 22 mutations) in complex with DRV
2YNG 2013-01-09 2.12 HIV-1 Reverse Transcriptase in complex with inhibitor GSK560
2YKN 2011-08-17 2.12 Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with a Difluoromethylbenzoxazole (DFMB) Pyrimidine Thioether derivative, a non-nucleoside RT inhibitor (NNRTI)
1ZTZ 2005-11-01 2.15 Crystal structure of HIV protease- metallacarborane complex
4DG1 2012-06-20 2.15 Crystal structure of HIV-1 reverse transcriptase (RT) with polymorphism mutation K172A and K173A
3EKP 2009-09-01 2.15 Crystal Structure of the inhibitor Amprenavir (APV) in complex with a multi-drug resistant HIV-1 protease variant (L10I/G48V/I54V/V64I/V82A)Refer: FLAP+ in citation
1MT8 2003-01-07 2.15 Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
1IZI 2002-12-23 2.15 Inhibitor of HIV protease with unusual binding mode potently inhibiting multi-resistant protease mutants
3LZV 2010-08-11 2.15 Structure of Nelfinavir-resistant HIV-1 protease (D30N/N88D) in complex with Darunavir.
5CYQ 2015-12-30 2.15 HIV-1 reverse transcriptase complexed with 4-bromopyrazole
4GVM 2013-05-01 2.16 HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor
5W4P 2018-06-20 2.19 Structure of the E28A mutant of the HIV-1 capsid protein
1K6C 2002-02-06 2.2 LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE
5OIA 2018-03-07 2.2 Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
1RTH 1996-04-03 2.2 HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
1HEG 1994-05-31 2.2 The crystal structures at 2.2 angstroms resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations
1AID 1997-10-15 2.2 STRUCTURE OF A NON-PEPTIDE INHIBITOR COMPLEXED WITH HIV-1 PROTEASE: DEVELOPING A CYCLE OF STRUCTURE-BASED DRUG DESIGN
5OI2 2018-03-07 2.2 Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
1N49 2003-01-07 2.2 Viability of a Drug-Resistant HIV-1 Protease Variant: Structural Insights for Better Anti-Viral Therapy
1HEF 1994-05-31 2.2 The crystal structures at 2.2 angstroms resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations
2B7Z 2006-11-14 2.2 Structure of HIV-1 protease mutant bound to indinavir
3UHL 2012-03-28 2.2 Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with p2-NC substrate analog
1HIH 1995-07-10 2.2 COMPARATIVE ANALYSIS OF THE X-RAY STRUCTURES OF HIV-1 AND HIV-2 PROTEASES IN COMPLEX WITH CGP 53820, A NOVEL PSEUDOSYMMETRIC INHIBITOR
3EKQ 2009-09-01 2.2 Crystal structure of inhibitor saquinavir (SQV) in complex with multi-drug resistant HIV-1 protease (L63P/V82T/I84V) (referred to as ACT in paper)
6ELI 2018-04-11 2.2 Structure of HIV-1 reverse transcriptase (RT) in complex with rilpivirine and an RNase H inhibitor XZ462
1T7J 2005-05-10 2.2 crystal structure of inhibitor amprenavir in complex with a multi-drug resistant variant of HIV-1 protease (L63P/V82T/I84V)
1LZQ 2003-04-29 2.2 Crystal structure of the complex of mutant HIV-1 protease (A71V, V82T, I84V) with an ethylenamine peptidomimetic inhibitor BOC-PHE-PSI[CH2CH2NH]-PHE-GLU-PHE-NH2
1VRT 1996-04-03 2.2 HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
1K2C 2002-07-10 2.2 Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
4F74 2013-05-15 2.2 Crystal Structure of active HIV-1 Protease in Complex with the N terminal product of the substrate MA-CA.
1HAR 1995-04-20 2.2 2.2 ANGSTROMS RESOLUTION STRUCTURE OF THE AMINO-TERMINAL HALF OF HIV-1 REVERSE TRANSCRIPTASE (FINGERS AND PALM SUBDOMAINS)
2QAK 2008-07-01 2.2 HIV-1 PR mutant in complex with nelfinavir
1U8G 2004-11-02 2.2 Crystal structure of a HIV-1 Protease in complex with peptidomimetic inhibitor KI2-PHE-GLU-GLU-NH2
1HTF 1994-07-31 2.2 X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE
3EM3 2009-09-01 2.2 Crystal structure of amprenavir (APV) in complex with a drug resistant HIV-1 protease variant (I50L/A71V).
1YTH 1997-03-12 2.2 SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT
4DGE 2012-02-08 2.2 TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant, HIV-1 CA(O-loop) complex
2Q63 2008-02-26 2.2 HIV-1 PR mutant in complex with nelfinavir
3KDC 2010-03-16 2.2 Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10074
3DLG 2008-08-12 2.2 Crystal structure of hiv-1 reverse transcriptase in complex with GW564511.
1Z8C 2006-03-21 2.2 Crystal structure of the complex of mutant HIV-1 protease (l63P, A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
1K6P 2002-02-06 2.2 LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE
1BHL 1998-10-14 2.2 CACODYLATED CATALYTIC DOMAIN OF HIV-1 INTEGRASE
6B2J 2018-09-26 2.21 E45A mutant of HIV-1 capsid protein (other crystal form)
4U0F 2014-11-12 2.22 Hexameric HIV-1 CA in Complex with BI-2
3T11 2012-08-22 2.22 Dimeric inhibitor of HIV-1 protease.
1UPJ 1996-10-14 2.22 HIV-1 PROTEASE COMPLEX WITH U095438 [3-[1-(4-BROMOPHENYL) ISOBUTYL]-4-HYDROXYCOUMARIN
6DUG 2018-08-01 2.22 Crystal structure of HIV-1 reverse transcriptase K101P mutant in complex with non-nucleoside inhibitor 25a
3TTP 2012-09-26 2.23 Structure of multiresistant HIV-1 protease in complex with darunavir
3LP1 2010-06-09 2.23 HIV-1 reverse transcriptase with inhibitor
5VQZ 2017-08-23 2.23 Crystal Structure of HIV-1 Reverse Transcriptase (K103N, Y181C) Variant in Complex with 2-chloro-N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacetamide (JLJ686), a Non-nucleoside Inhibitor
4O55 2014-07-02 2.24 HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[6-(5-chloro-1H-benzimidazol-2-yl)-2,5-dimethyl-4-phenylpyridin-3-yl]ethanoic acid
2NXM 2007-09-18 2.25 Structure of HIV-1 protease D25N complexed with the rt-rh analogue peptide GLY-ALA-GLN-THR-PHE*TYR-VAL-ASP-GLY-ALA
3PJ6 2011-04-06 2.25 Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants
1HVS 1995-02-14 2.25 STRUCTURAL BASIS OF DRUG RESISTANCE FOR THE V82A MUTANT OF HIV-1 PROTEASE: BACKBONE FLEXIBILITY AND SUBSITE REPACKING
3OQA 2011-04-06 2.25 Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants
1K6T 2002-02-06 2.25 LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE
5W4Q 2018-06-20 2.29 Structure of the R18A/E28A mutant of the HIV-1 capsid protein
1EBY 2002-06-26 2.29 HIV-1 protease in complex with the inhibitor BEA369
1A9M 1998-06-17 2.3 G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E
4I2P 2013-01-16 2.3 Crystal structure of HIV-1 reverse transcriptase in complex with rilpivirine (TMC278) based analogue
2OPS 2007-05-22 2.3 Crystal Structure of Y188C Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
3DYA 2008-11-25 2.3 HIV-1 RT with non-nucleoside inhibitor annulated Pyrazole 1
1GNO 1996-11-08 2.3 HIV-1 PROTEASE (WILD TYPE) COMPLEXED WITH U89360E (INHIBITOR)
6AXR 2018-09-12 2.3 Structure of the P122A mutant of the HIV-1 capsid protein
1GNN 1996-11-08 2.3 HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASN (V82N) COMPLEXED WITH U89360E (INHIBITOR)
4KV8 2013-07-31 2.3 Crystal structure of HIV RT in complex with BILR0355BS
3LAK 2010-02-23 2.3 Crystal structure of HIV-1 reverse transcriptase in complex with N1-heterocycle pyrimidinedione non-nucleoside inhibitor
1HXB 1997-03-12 2.3 HIV-1 proteinase complexed with RO 31-8959
1ZLF 2006-04-25 2.3 Crystal structure of a complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor
1HIW 1996-10-14 2.3 TRIMERIC HIV-1 MATRIX PROTEIN
1GNM 1996-11-08 2.3 HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASP (V82D) COMPLEXED WITH U89360E (INHIBITOR)
1TCX 1996-12-07 2.3 HIV TRIPLE MUTANT PROTEASE COMPLEXED WITH INHIBITOR SB203386
2QNQ 2008-04-15 2.3 HIV-1 Protease in complex with a chloro decorated pyrrolidine-based inhibitor
1SBG 1994-10-15 2.3 AN ORALLY-BIOAVAILABLE HIV-1 PROTEASE INHIBITOR CONTAINING AN IMIDAZOLE-DERIVED PEPTIDE BOND REPLACEMENT. CRYSTALLOGRAPHIC AND PHARMACOKINETIC ANALYSIS
5D3G 2015-09-30 2.3 Structure of HIV-1 Reverse Transcriptase Bound to a Novel 38-mer Hairpin Template-Primer DNA Aptamer
3MEC 2010-05-12 2.3 HIV-1 Reverse Transcriptase in Complex with TMC125
1ITG 1995-05-08 2.3 CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE: SIMILARITY TO OTHER POLYNUCLEOTIDYL TRANSFERASES
1HPS 1994-08-31 2.3 RATIONAL DESIGN, SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS OF A HYDROXYETHYLENE-BASED HIV-1 PROTEASE INHIBITOR CONTAINING A HETEROCYCLIC P1'-P2' AMIDE BOND ISOSTERE
4HVP 1990-04-15 2.3 Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 Angstroms resolution
5OI3 2018-03-07 2.3 Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
2RKI 2008-04-22 2.3 Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with a triazole derived NNRTI
1HBV 1995-07-10 2.3 A CHECK ON RATIONAL DRUG DESIGN. CRYSTAL STRUCTURE OF A COMPLEX OF HIV-1 PROTEASE WITH A NOVEL GAMMA-TURN MIMETIC
1YTG 1997-03-12 2.3 SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT
1HOS 1993-10-31 2.3 INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE BY A C2-SYMMETRIC PHOSPHINATE SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS
4K4P 2013-09-18 2.31 TL-3 inhibited Trp6Ala HIV Protease
2Z54 2008-07-01 2.31 The Influence of I47A Mutation on Reduced Susceptibility to the Protease Inhibitor Lopinavir
5OI8 2018-03-07 2.35 Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
1RTJ 1996-04-03 2.35 MECHANISM OF INHIBITION OF HIV-1 REVERSE TRANSCRIPTASE BY NON-NUCLEOSIDE INHIBITORS
4EJ8 2013-05-01 2.35 Apo HIV Protease (PR) dimer in closed form with fragment 1F1 in the outside/top of flap
5VQY 2017-08-23 2.35 Crystal Structure of HIV-1 Reverse Transcriptase (K103N, Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacrylamide (JLJ684), a Non-nucleoside Inhibitor
4CPQ 2014-12-17 2.35 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
2YNF 2013-01-09 2.36 HIV-1 Reverse Transcriptase Y188L mutant in complex with inhibitor GSK560
1AK4 1997-10-15 2.36 HUMAN CYCLOPHILIN A BOUND TO THE AMINO-TERMINAL DOMAIN OF HIV-1 CAPSID
4O5B 2014-07-02 2.37 HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[6-(5-chloro-1H-benzimidazol-2-yl)-2,5-dimethyl-4-phenylpyridin-3-yl]ethanoic acid
5XN2 2018-02-07 2.38 HIV-1 reverse transcriptase Q151M:DNA:dGTP ternary complex
6EWA 2018-11-07 2.39 Crystal structure of HLA-A2 in complex with LILRB1
2RF2 2008-01-01 2.4 HIV reverse transcriptase in complex with inhibitor 7e (NNRTI)
6AXT 2018-09-12 2.4 Structure of the T58S/T107I/P122A mutant of the HIV-1 capsid protein
6CPO 2018-06-06 2.4 Crystal structure of DR15 presenting the RQ13 peptide
4G8G 2013-03-20 2.4 Crystal Structure of C12C TCR-HA B2705-KK10
3MEE 2010-05-12 2.4 HIV-1 Reverse Transcriptase in Complex with TMC278
1S1T 2004-06-29 2.4 Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with UC-781
1VRU 1996-04-03 2.4 HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
3T1A 2011-10-26 2.4 Crystal Structure of HIV-1 Reverse Transcriptase (K103N mutant) in Complex with Inhibitor M05
5OI5 2018-03-07 2.4 Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
1HRH 1992-01-15 2.4 CRYSTAL STRUCTURE OF THE RIBONUCLEASE H DOMAIN OF HIV-1 REVERSE TRANSCRIPTASE
3DS5 2008-09-02 2.4 HIV-1 capsid C-terminal domain mutant (N183A)
6AXW 2018-09-12 2.4 Structure of the I124A mutant of the HIV-1 capsid protein
7HVP 1993-07-15 2.4 X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN A SYNTHETIC PROTEASE OF HUMAN IMMUNODEFICIENCY VIRUS 1 AND A SUBSTRATE-BASED HYDROXYETHYLAMINE INHIBITOR
1K6Y 2001-12-21 2.4 Crystal Structure of a Two-Domain Fragment of HIV-1 Integrase
1Q94 2004-06-01 2.4 Structures of HLA-A*1101 in complex with immunodominant nonamer and decamer HIV-1 epitopes clearly reveal the presence of a middle anchor residue
1VIJ 1999-01-13 2.4 HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR HOE/BAY 793 HEXAGONAL FORM
6AXS 2018-09-12 2.4 Structure of the V11I/T58A/P122A mutant of the HIV-1 capsid protein
6AYA 2018-09-12 2.4 Structure of the native full-length HIV-1 capsid protein in complex with Nup153 peptide
1VIK 1998-12-09 2.4 HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR HOE/BAY 793 ORTHORHOMBIC FORM
5K14 2016-06-29 2.4 HIV-1 Reverse Transcriptase in complex with a 2,6-difluorophenyl DAPY analog
5VQX 2017-08-23 2.4 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with 2-chloro-N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacetamide (JLJ686), a Non-nucleoside Inhibitor
6CQL 2018-06-06 2.4 Crystal structure of F24 TCR -DR11-RQ13 peptide complex
6B2G 2018-09-26 2.41 P38A mutant of HIV-1 capsid protein
5J2M 2016-08-03 2.43 HIV-1 reverse transcriptase in complex with DNA and EFdA-triphosphate, a translocation-defective RT inhibitor
4XFX 2015-06-10 2.43 Structure of the native full-length HIV-1 capsid protein
2BE2 2005-12-06 2.43 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with R221239
6IK9 2019-01-30 2.43 HIV-1 reverse transcriptase with Q151M/G112S/D113A/Y115F/F116Y/F160L/I159L:DNA:dGTP ternary complex
6BSG 2018-01-03 2.44 Structure of HIV-1 RT complexed with RNA/DNA hybrid in an RNA hydrolysis-off mode
4EJL 2013-05-01 2.44 Apo HIV Protease (PR) dimer in closed form with fragment 1F1-N in the outside/top of flap
5XN1 2018-02-07 2.45 HIV-1 reverse transcriptase Q151M:DNA:entecavir-triphosphate ternary complex
4COE 2014-12-10 2.45 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
4QLH 2014-08-06 2.45 Crystal structure of drug resistant V82S/V1082S HIV-1 Protease
4DMN 2012-03-21 2.45 HIV-1 Integrase Catalytical Core Domain
1M0B 2004-01-13 2.45 HIV-1 protease in complex with an ethyleneamine inhibitor
6CPL 2018-06-06 2.45 Crystal structure of DR11 presenting the gag293 epitope
2YNI 2013-01-09 2.49 HIV-1 Reverse Transcriptase in complex with inhibitor GSK952
4WE1 2014-12-03 2.49 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ600)
3ISN 2010-03-16 2.5 Crystal structure of HIV-1 RT bound to A 6-vinylpyrimidine inhibitor
5VQS 2017-08-23 2.5 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)acrylamide (JLJ685), a Non-nucleoside Inhibitor
1MTB 2003-01-07 2.5 Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
6AVM 2018-08-15 2.5 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 9.5 WITH CROSS-LINKING TO SECOND BASE TEMPLATE OVERHANG
3N3I 2010-06-09 2.5 Crystal Structure of G48V/C95F tethered HIV-1 Protease/Saquinavir complex
1FK9 2000-11-03 2.5 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
4IG0 2013-02-06 2.5 HIV-1 reverse transcriptase with bound fragment at the 507 site
1JKH 2001-10-03 2.5 CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
4I7F 2013-02-20 2.5 HIV-1 Reverse Transcriptase in complex with a phosphonate analog of nevirapine
6AMO 2018-08-15 2.5 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 7.0
1BIU 1998-08-19 2.5 HIV-1 INTEGRASE CORE DOMAIN COMPLEXED WITH MG++
5VQW 2017-08-23 2.5 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)acrylamide (JLJ685), a Non-nucleoside Inhibitor
5TSV 2017-11-08 2.5 HIV-1 CA hexamer with NUP153 peptide - R3 crystal form
6CQN 2018-06-06 2.5 Crystal structure of F5 TCR -DR11-RQ13 peptide complex
1SH9 2004-10-05 2.5 Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease
2AZ9 2006-02-28 2.5 HIV-1 Protease NL4-3 1X mutant
6B2I 2018-09-26 2.5 E45A mutant of the HIV-1 capsid protein
3P05 2011-01-12 2.5 X-ray structure of pentameric HIV-1 CA
1EP4 2000-09-27 2.5 Crystal structure of HIV-1 reverse transcriptase in complex with S-1153
3MED 2010-05-12 2.5 HIV-1 K103N Reverse Transcriptase in Complex with TMC125
1C1C 2000-07-21 2.5 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-6123
1D4S 1999-10-12 2.5 HIV-1 PROTEASE V82F/I84V DOUBLE MUTANT/TIPRANAVIR COMPLEX
1HPO 1997-04-21 2.5 HIV-1 PROTEASE TRIPLE MUTANT/U103265 COMPLEX
3AID 1997-09-17 2.5 A NEW CLASS OF HIV-1 PROTEASE INHIBITOR: THE CRYSTALLOGRAPHIC STRUCTURE, INHIBITION AND CHEMICAL SYNTHESIS OF AN AMINIMIDE PEPTIDE ISOSTERE
5TXL 2017-04-05 2.5 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP
1A8G 1998-07-15 2.5 HIV-1 PROTEASE IN COMPLEX WITH SDZ283-910
2HNY 2006-09-05 2.5 Crystal Structure of E138K Mutant HIV-1 Reverse Transcriptase in Complex with Nevirapine
6AY9 2018-09-12 2.5 Structure of the native full-length HIV-1 capsid protein in complex with CPSF6 peptide
3DLE 2008-08-12 2.5 Crystal structure of hiv-1 reverse transcriptase in complex with GF128590.
2HND 2006-09-05 2.5 Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with Nevirapine
2Q64 2008-02-26 2.5 HIV-1 PR mutant in complex with nelfinavir
1AAQ 1994-06-22 2.5 HYDROXYETHYLENE ISOSTERE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE: STRUCTURE-ACTIVITY ANALYSIS USING ENZYME KINETICS, X-RAY CRYSTALLOGRAPHY, AND INFECTED T-CELL ASSAYS
2BPZ 1999-02-23 2.5 HIV-1 protease-inhibitor complex
1BI4 1998-11-04 2.5 CATALYTIC DOMAIN OF HIV-1 INTEGRASE
1C1B 2000-07-21 2.5 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GCA-186
5IM7 2016-10-05 2.5 Crystal structure of HLA-B5801, a protective HLA allele for HIV-1 infection
2IAJ 2006-12-19 2.5 Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with ATP
1JLA 2001-10-03 2.5 CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-651
3GGA 2009-05-26 2.5 HIV Protease inhibitors with pseudo-symmetric cores
8HVP 1993-10-31 2.5 STRUCTURE AT 2.5-ANGSTROMS RESOLUTION OF CHEMICALLY SYNTHESIZED HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE COMPLEXED WITH A HYDROXYETHYLENE*-BASED INHIBITOR
1BDQ 1998-08-12 2.5 HIV-1 (2:31-37, 47, 82) PROTEASE COMPLEXED WITH INHIBITOR SB203386
4PQU 2014-06-18 2.51 Crystal structure of HIV-1 Reverse Transcriptase in complex with RNA/DNA and dATP
3LAL 2010-02-23 2.51 Crystal structure of HIV-1 reverse transcriptase in complex with N1-ethyl pyrimidinedione non-nucleoside inhibitor
3TAM 2011-10-26 2.51 Crystal structure of HIV-1 reverse transcriptase (K103N mutant) in complex with inhibitor M06
1C0U 2000-07-19 2.52 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+50.0934
5J2P 2016-08-03 2.53 HIV-1 reverse transcriptase in complex with DNA that has incorporated EFdA-MP at the P-(post-translocation) site and a second EFdA-MP at the N-(pre-translocation) site
6OR7 2019-07-24 2.53 Structure of HIV-1 Reverse Transcriptase (RT) in complex with DNA AND (-)FTC-TP
3LAN 2010-02-23 2.55 Crystal structure of HIV-1 reverse transcriptase in complex with N1-butyl pyrimidinedione non-nucleoside inhibitor
6P1X 2019-07-24 2.55 Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and L-ddCTP
3IS9 2010-04-07 2.55 Crystal structure of the HIV-1 reverse transcriptase (RT) in complex with the alkenyldiarylmethane (ADAM) Non-nucleoside RT Inhibitor dimethyl 3,3'-(6-methoxy-6-oxohex-1-ene-1,1-diyl)bis(5-cyano-6-methoxybenzoate).
1RT1 1997-04-21 2.55 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH MKC-442
2OPP 2007-05-22 2.55 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with GW420867X.
5VQR 2017-08-23 2.55 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacrylamide (JLJ684), a Non-nucleoside Inhibitor
5TXO 2017-04-05 2.55 STRUCTURE OF Q151M complex (A62V, V75I, F77L, F116Y, Q151M) mutant HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP
1RT2 1997-04-21 2.55 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH TNK-651
5VQQ 2017-08-23 2.55 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-2-fluoro-N-methylacetamide (JLJ683), a Non-nucleoside Inhibitor
5TXN 2017-04-05 2.55 STRUCTURE OF Q151M MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP
5VQT 2017-08-23 2.56 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 2-chloro-N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacetamide (JLJ686), a Non-nucleoside Inhibitor
5VQV 2017-08-23 2.58 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacrylamide (JLJ684), a Non-nucleoside Inhibitor
4NCG 2014-02-12 2.58 Discovery of Doravirine, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses
6ANQ 2018-08-15 2.59 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 8.5
1S9E 2004-05-11 2.6 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R129385
3T19 2011-10-26 2.6 Crystal structure of HIV-1 reverse transcriptase (wild type) in complex with inhibitor M05
4WYM 2014-12-17 2.6 Structural basis of HIV-1 capsid recognition by CPSF6
6IKA 2019-01-30 2.6 HIV-1 reverse transcriptase with Q151M/G112S/D113A/Y115F/F116Y/F160L/I159L:DNA:entecavir-triphosphate ternary complex
1FB7 2000-12-13 2.6 CRYSTAL STRUCTURE OF AN IN VIVO HIV-1 PROTEASE MUTANT IN COMPLEX WITH SAQUINAVIR: INSIGHTS INTO THE MECHANISMS OF DRUG RESISTANCE
1A43 1999-02-09 2.6 STRUCTURE OF THE HIV-1 CAPSID PROTEIN DIMERIZATION DOMAIN AT 2.6A RESOLUTION
3FFI 2009-12-15 2.6 HIV-1 RT with pyridone non-nucleoside inhibitor
5XN0 2018-02-07 2.6 HIV-1 reverse transcriptase Q151M:DNA binary complex
6AN8 2018-08-15 2.6 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 8.0
3DRP 2008-10-14 2.6 HIV reverse transcriptase in complex with inhibitor R8e
4ZHR 2015-11-11 2.6 Structure of HIV-1 RT Q151M mutant
6AXX 2018-09-12 2.6 Structure of the T58A/I124A mutant of the HIV-1 capsid protein
1TKT 2004-12-07 2.6 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW426318
5C24 2015-07-29 2.6 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 7-((4-((4-cyanophenyl)amino)-1,3,5-triazin-2-yl)amino)-6,8-dimethylindolizine-2-carbonitrile (JLJ605), a non-nucleoside inhibitor
1JLF 2001-10-03 2.6 CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
5VQU 2017-08-23 2.6 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-2-fluoro-N-methylacetamide (JLJ683), a Non-nucleoside Inhibitor
1BAJ 1998-10-14 2.6 HIV-1 CAPSID PROTEIN C-TERMINAL FRAGMENT PLUS GAG P2 DOMAIN
1JLG 2001-10-03 2.6 CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH UC-781
1REV 1996-10-14 2.6 HIV-1 REVERSE TRANSCRIPTASE
6AVT 2018-08-15 2.6 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 9.5 WITH CROSS-LINKING TO FIRST BASE TEMPLATE OVERHANG
1S1V 2004-06-29 2.6 Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with TNK-651
6B2H 2018-09-26 2.6 P38A/T216I mutant of the HIV-1 capsid protein
3QO9 2011-05-04 2.6 Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with TSAO-T, a non-nucleoside RT inhibitor (NNRTI)
2ITG 1997-03-12 2.6 CATALYTIC DOMAIN OF HIV-1 INTEGRASE: ORDERED ACTIVE SITE IN THE F185H CONSTRUCT
6ASW 2018-08-15 2.61 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 9.0
1LWC 2002-10-30 2.62 CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
6GL1 2018-08-08 2.62 HLA-E*01:03 in complex with the HIV epitope, RL9HIV
4RW6 2015-04-29 2.63 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) variant in complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor
5EU7 2016-09-28 2.64 Crystal structure of HIV-1 integrase catalytic core in complex with Fab
3KLI 2010-09-22 2.65 Crystal structure of unliganded AZT-resistant HIV-1 Reverse Transcriptase
3DI6 2008-08-19 2.65 HIV-1 RT with pyridazinone non-nucleoside inhibitor
6BSH 2018-01-03 2.65 Structure of HIV-1 RT complexed with RNA/DNA hybrid in the RNA hydrolysis mode
2B6A 2005-11-01 2.65 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with THR-50
1KLM 1998-03-18 2.65 HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH BHAP U-90152
4GW6 2013-05-01 2.65 HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor
6OUN 2019-07-24 2.66 Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (-)3TC-TP
3M8P 2010-05-19 2.67 HIV-1 RT with NNRTI TMC-125
4RW4 2015-04-29 2.67 Crystal Structure of HIV-1 Reverse Transcriptase (K103N,Y181C) variant in complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor
4KSE 2014-08-13 2.68 Crystal structure of a HIV p51 (219-230) deletion mutant
6BHT 2018-08-01 2.69 HIV-1 CA hexamer in complex with IP6, orthorhombic crystal form
4LSL 2013-12-25 2.69 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-(4-chloro-2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ476), a non-nucleoside inhibitor
3C6U 2008-04-22 2.7 Crystal Structure of HIV Reverse Transcriptase in complex with inhibitor 22
1C0T 2000-07-19 2.7 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+21.1326
5TUQ 2017-06-28 2.7 Crystal Structure of a 6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione Inhibitor in Complex with HIV Reverse Transcriptase
3C6T 2008-04-22 2.7 Crystal Structure of HIV Reverse Transcriptase in complex with inhibitor 14
3KK1 2010-03-23 2.7 HIV-1 reverse transcriptase-DNA complex with nuceotide inhibitor GS-9148-diphosphate bound in nucleotide site
3V6D 2012-01-18 2.7 Crystal structure of HIV-1 reverse transcriptase (RT) cross-linked with AZT-terminated DNA
3DS3 2008-09-02 2.7 HIV-1 capsid C-terminal domain mutant (Y169A) in complex with an inhibitor of particle assembly (CAI)
3I0S 2009-08-25 2.7 crystal structure of HIV reverse transcriptase in complex with inhibitor 7
1HQU 2001-05-30 2.7 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
1HQE 2001-05-30 2.7 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
1DLO 1996-08-01 2.7 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
1HHP 1992-10-15 2.7 THE THREE-DIMENSIONAL STRUCTURE OF THE ASPARTYL PROTEASE FROM THE HIV-1 ISOLATE BRU
5TXP 2017-04-05 2.7 STRUCTURE OF Q151M complex (A62V, V75I, F77L, F116Y, Q151M) mutant HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DDATP
3M8Q 2010-05-19 2.7 HIV-1 RT with AMINOPYRIMIDINE NNRTI
4XFZ 2015-06-10 2.7 Structure of the native full-length HIV-1 capsid protein in complex with PF-3450074 (PF74)
3H4E 2009-06-23 2.7 X-ray Structure of Hexameric HIV-1 CA
4I2Q 2013-01-16 2.7 Crystal structure of K103N/Y181C mutant of HIV-1 reverse transcriptase in complex with rilpivirine (TMC278) analogue
5TXM 2017-04-05 2.7 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DDATP
1S1W 2004-06-29 2.7 Crystal structure of V106A mutant HIV-1 reverse transcriptase in complex with UC-781
5TER 2017-01-11 2.7 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-chloro-7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-8-methyl-2-naphthonitrile (JLJ651), a Non-nucleoside Inhibitor
3PHV 1992-01-15 2.7 X-RAY ANALYSIS OF HIV-1 PROTEINASE AT 2.7 ANGSTROMS RESOLUTION CONFIRMS STRUCTURAL HOMOLOGY AMONG RETROVIRAL ENZYMES
3GGX 2009-05-26 2.7 HIV Protease, pseudo-symmetric inhibitors
2FDE 2006-02-21 2.7 Wild type HIV protease bound with GW0385
3QLH 2011-12-21 2.7 HIV-1 Reverse Transcriptase in Complex with Manicol at the RNase H Active Site and TMC278 (Rilpivirine) at the NNRTI Binding Pocket
6AN2 2018-08-15 2.7 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 7.5
4O4G 2014-11-05 2.71 Crystal Structure of HIV-1 Reverse Transcriptase in complex with 4-((4-(mesitylamino)-1,3,5-triazin-2-yl)amino)benzonitrile (JLJ527), a non-nucleoside inhibitor
1EET 2001-02-07 2.73 HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH THE INHIBITOR MSC204
6P1I 2019-07-24 2.74 Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and dCTP
6CQJ 2018-06-06 2.75 Crystal structure of DR1 presenting the RQ13 peptide
5HRO 2016-06-01 2.75 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A DNA aptamer and an Alpha-carboxy nucleoside phosphonate inhibitor (alpha-CNP)
3LAM 2010-02-23 2.76 Crystal structure of HIV-1 reverse transcriptase in complex with N1-propyl pyrimidinedione non-nucleoside inhibitor
5O2U 2017-06-21 2.76 Llama VHH in complex with p24
6AXV 2018-09-12 2.77 Structure of the T58S/T107I/P122A mutant of the HIV-1 capsid protein in complex with PF-3450074 (PF74)
6AXY 2018-09-12 2.78 Structure of the V11I/T58A/I124A mutant of the HIV-1 capsid protein
5XOT 2017-06-14 2.79 Crystal structure of pHLA-B35 in complex with TU55 T cell receptor
4DQG 2012-03-07 2.79 Crystal Structure of apo(G16C/L38C) HIV-1 Protease
3LP0 2010-06-09 2.79 HIV-1 reverse transcriptase with inhibitor
5J2Q 2016-08-03 2.79 HIV-1 reverse transcriptase in complex with DNA that has incorporated a mismatched EFdA-MP at the N-(pre-translocation) site
1R0A 2004-08-03 2.8 Crystal structure of HIV-1 reverse transcriptase covalently tethered to DNA template-primer solved to 2.8 angstroms
1S9G 2004-05-11 2.8 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R120394.
1HTE 1994-07-31 2.8 X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE
1RDH 1994-05-31 2.8 CRYSTALLOGRAPHIC ANALYSES OF AN ACTIVE HIV-1 RIBONUCLEASE H DOMAIN SHOW STRUCTURAL FEATURES THAT DISTINGUISH IT FROM THE INACTIVE FORM
4U0B 2014-11-12 2.8 Hexamer HIV-1 CA in complex with CPSF6 peptide, P212121 crystal form
2VG5 2007-12-11 2.8 Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors
9HVP 1992-04-15 2.8 Design, activity and 2.8 Angstroms crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease
1BDL 1998-08-12 2.8 HIV-1 (2:31-37) PROTEASE COMPLEXED WITH INHIBITOR SB203386
1IKX 2001-06-06 2.8 K103N Mutant HIV-1 Reverse Transcriptase in Complex with the Inhibitor PNU142721
3ITH 2010-03-16 2.8 Crystal structure of the HIV-1 reverse transcriptase bound to a 6-vinylpyrimidine inhibitor
2HMI 1998-10-14 2.8 HIV-1 REVERSE TRANSCRIPTASE/FRAGMENT OF FAB 28/DNA COMPLEX
1DTQ 2000-03-20 2.8 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-1 (PETT131A94)
4XFY 2015-06-10 2.8 Structure of the native full-length dehydrated HIV-1 capsid protein
2WON 2010-08-11 2.8 Crystal Structure of UK-453061 bound to HIV-1 Reverse Transcriptase (wild-type).
3LP3 2010-06-09 2.8 p15 HIV RNaseH domain with inhibitor MK3
2BPX 1999-02-23 2.8 HIV-1 protease-inhibitor complex
1RT6 1999-07-29 2.8 HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC38
3MEG 2010-05-12 2.8 HIV-1 K103N Reverse Transcriptase in Complex with TMC278
6CQQ 2018-06-06 2.8 Crystal structure of F24 TCR -DR15-RQ13 peptide complex
3IG1 2010-01-26 2.8 HIV-1 Reverse Transcriptase with the Inhibitor beta-Thujaplicinol Bound at the RNase H Active Site
1TV6 2004-07-20 2.8 HIV-1 Reverse Transcriptase Complexed with CP-94,707
2OPQ 2007-05-22 2.8 Crystal Structure of L100I Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
1JLE 2001-10-03 2.8 CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE
1LW0 2002-10-30 2.8 CRYSTAL STRUCTURE OF T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
2BPW 1999-02-23 2.8 HIV-1 protease-inhibitor complex
1HNI 1995-06-03 2.8 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN A COMPLEX WITH THE NONNUCLEOSIDE INHIBITOR ALPHA-APA R 95845 AT 2.8 ANGSTROMS RESOLUTION
3S85 2012-04-11 2.8 Discovery of New HIV Protease Inhibitors with Potential for Convenient Dosing and Reduced Side Effects: A-790742 and A-792611.
3V4I 2012-01-18 2.8 Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and AZTTP
1LWF 2002-10-30 2.8 CRYSTAL STRUCTURE OF A MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMQ+M184V: M41L/D67N/K70R/M184V/T215Y) IN COMPLEX WITH NEVIRAPINE
1EX4 2000-06-07 2.8 HIV-1 INTEGRASE CATALYTIC CORE AND C-TERMINAL DOMAIN
3IRX 2010-04-07 2.8 Crystal Structure of HIV-1 reverse transcriptase (RT) in complex with the Non-nucleoside RT Inhibitor (E)-S-Methyl 5-(1-(3,7-Dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-5-(5-methyl-1,3,4-oxadiazol-2-yl)pent-1-enyl)-2-methoxy-3-methylbenzothioate.
3LP2 2010-06-09 2.8 HIV-1 reverse transcriptase with inhibitor
1BDR 1998-10-14 2.8 HIV-1 (2: 31, 33-37) PROTEASE COMPLEXED WITH INHIBITOR SB203386
3HVP 1989-10-15 2.8 CONSERVED FOLDING IN RETROVIRAL PROTEASES. CRYSTAL STRUCTURE OF A SYNTHETIC HIV-1 PROTEASE
1S1X 2004-06-29 2.8 Crystal structure of V108I mutant HIV-1 reverse transcriptase in complex with nevirapine
1TL3 2004-12-07 2.8 Crystal structure of hiv-1 reverse transcriptase in complex with gw450557
1LWE 2002-10-30 2.81 CRYSTAL STRUCTURE OF M41L/T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMN) IN COMPLEX WITH NEVIRAPINE
6BHJ 2018-10-31 2.81 Structure of HIV-1 Reverse Transcriptase Bound to a 38-mer Hairpin Template-Primer RNA-DNA Aptamer
1TKZ 2004-12-07 2.81 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW429576
2VG7 2007-12-11 2.82 Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors
5C25 2015-07-29 2.84 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 6-((4-((4-cyanophenyl)amino)-1,3,5-triazin-2-yl)amino)-5,7-dimethyl-2-naphthonitrile (JLJ639), a Non-nucleoside Inhibitor
1TKX 2004-12-07 2.85 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745
3V81 2012-01-18 2.85 Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and the nonnucleoside inhibitor nevirapine
5TW3 2017-03-15 2.85 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)-4-fluorophenoxy)-7-fluoro-2-naphthonitrile (JLJ636), a Non-nucleoside Inhibitor
4H4M 2012-12-05 2.85 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor
1QE1 1999-08-30 2.85 CRYSTAL STRUCTURE OF 3TC-RESISTANT M184I MUTANT OF HIV-1 REVERSE TRANSCRIPTASE
6OTZ 2019-07-24 2.86 Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (+)FTC-TP
4RW8 2015-04-29 2.88 Crystal Structure of HIV-1 Reverse Transcriptase in complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ532), a non-nucleoside inhibitor'
5V5M 2017-06-14 2.88 Crystal structure of HLA-B*5701 complex with HIV-1 gag derived peptide TW10
4MFB 2013-11-06 2.88 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)indolizine-2-carbonitrile (JLJ555), a non-nucleoside inhibitor
4R5P 2015-03-11 2.89 Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and a nucleoside triphosphate mimic alpha-carboxy nucleoside phosphonate inhibitor
3DRR 2008-10-14 2.89 HIV reverse transcriptase Y181C mutant in complex with inhibitor R8e
4KKO 2013-08-14 2.89 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 4-((4-methoxy-6-(2-morpholinoethoxy)-1,3,5-triazin-2-yl)amino)-2-((3-methylbut-2-en-1-yl)oxy)benzonitrile (JLJ513), a non-nucleoside inhibitor
6BSJ 2018-01-03 2.89 Structure of HIV-1 RT complexed with an RNA/DNA hybrid sequence non-preferred for RNA hydrolysis
4O44 2014-05-21 2.89 Crystal Structure of HIV-1 Reverse Transcriptase in complex with 4-((4-(mesitylamino)-6-(3-morpholinopropoxy)-1,3,5-triazin-2-yl)amino)benzonitrile (JLJ529), a non-nucleoside inhibitor
2OPR 2007-05-22 2.9 Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
5HP1 2016-06-01 2.9 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A DNA aptamer and FOSCARNET, a Pyrophosphate analog
1SV5 2004-05-11 2.9 CRYSTAL STRUCTURE OF K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R165335
3DOK 2008-08-12 2.9 Crystal structure of K103N mutant HIV-1 reverse transcriptase in complex with GW678248.
1RT4 1999-07-29 2.9 HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC781
3HVT 1994-10-15 2.9 STRUCTURAL BASIS OF ASYMMETRY IN THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE HETERODIMER
3KLH 2010-09-22 2.9 Crystal structure of AZT-Resistant HIV-1 Reverse Transcriptase crosslinked to post-translocation AZTMP-Terminated DNA (COMPLEX P)
3KK2 2010-03-23 2.9 HIV-1 reverse transcriptase-DNA complex with dATP bound in the nucleotide binding site
1S6P 2004-05-11 2.9 CRYSTAL STRUCTURE OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R100943
2ZE2 2008-02-12 2.9 Crystal structure of L100I/K103N mutant HIV-1 reverse transcriptase (RT) in complex with TMC278 (rilpivirine), a non-nucleoside RT inhibitor
1RT5 1999-07-29 2.9 HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC10
2B5J 2005-12-06 2.9 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with JANSSEN-R165481
5J2N 2016-08-03 2.9 HIV-1 reverse transcriptase in complex with DNA that has incorporated EFdA-MP at the P-(post-translocation) site and dTMP at the N-(pre-translocation) site
3KK3 2010-03-23 2.9 HIV-1 reverse transcriptase-DNA complex with GS-9148 terminated primer
2YKM 2011-08-17 2.9 Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with a Difluoromethylbenzoxazole (DFMB) Pyrimidine Thioether derivative, a non-nucleoside RT inhibitor (NNRTI)
4PUO 2014-06-18 2.9 Crystal structure of HIV-1 reverse transcriptase in complex with RNA/DNA and Nevirapine
5J1E 2016-06-15 2.9 Crystal Structure of a Hydroxypyridone Carboxylic Acid Active-Site RNase H Inhibitor in Complex with HIV Reverse Transcriptase
4H4O 2012-12-05 2.9 Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with (E)-3-(3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)- 4-fluorophenoxy)-5-fluorophenyl)acrylonitrile (JLJ506), A Non-nucleoside inhibitor
1FKP 2000-11-03 2.9 CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
2YNH 2013-01-09 2.9 HIV-1 Reverse Transcriptase in complex with inhibitor GSK500
6OE3 2019-05-15 2.9 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-7-fluoro-2-naphthonitrile (JLJ635), a Non-nucleoside Inhibitor
1TL1 2004-12-07 2.9 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW451211
1FKO 2000-11-03 2.9 CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
1KJ4 2002-03-06 2.9 SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES
3NBP 2010-08-18 2.95 HIV-1 reverse transcriptase with aminopyrimidine inhibitor 2
5HLF 2016-02-10 2.95 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A 38-MER HAIRPIN TEMPLATE-PRIMER DNA APTAMER AND AN ALPHA-CARBOXYPHOSPHONATE INHIBITOR
2BAN 2005-12-06 2.95 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with JANSSEN-R157208
3E01 2008-11-25 2.95 HIV-RT with non-nucleoside inhibitor annulated pyrazole 2
3I0R 2009-08-25 2.98 crystal structure of HIV reverse transcriptase in complex with inhibitor 3
4RW9 2015-04-29 2.99 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) variant in complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ532), a non-nucleoside inhibitor
6P2G 2019-07-24 2.99 Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and D-ddCTP
1IKY 2001-06-06 3.0 HIV-1 Reverse Transcriptase in Complex with the Inhibitor MSC194
1LW2 2002-10-30 3.0 CRYSTAL STRUCTURE OF T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH 1051U91
2UPJ 1996-10-14 3.0 HIV-1 PROTEASE COMPLEX WITH U100313 ([3-[[3-[CYCLOPROPYL [4-HYDROXY-2OXO-6-[1-(PHENYLMETHYL)PROPYL]-2H-PYRAN-3-YL] METHYL]PHENYL]AMINO]-3-OXO-PROPYL]CARBAMIC ACID TERT-BUTYL ESTER)
1RTI 1996-04-03 3.0 HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
1YT9 2005-04-12 3.0 HIV Protease with oximinoarylsulfonamide bound
2HNZ 2006-09-05 3.0 Crystal Structure of E138K Mutant HIV-1 Reverse Transcriptase in Complex with PETT-2
1S1U 2004-06-29 3.0 Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with nevirapine
1IKW 2001-06-06 3.0 Wild Type HIV-1 Reverse Transcriptase in Complex with Efavirenz
1JLB 2001-10-03 3.0 CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
1AUM 1998-01-14 3.0 HIV CAPSID C-TERMINAL DOMAIN (CAC146)
3JSM 2009-09-29 3.0 K65R mutant HIV-1 reverse transcriptase cross-linked to DS-DNA and complexed with tenofovir-diphosphate as the incoming nucleotide substrate
1T05 2004-05-11 3.0 HIV-1 reverse transcriptase crosslinked to template-primer with tenofovir-diphosphate bound as the incoming nucleotide substrate
2HVP 1989-04-19 3.0 THREE-DIMENSIONAL STRUCTURE OF ASPARTYL PROTEASE FROM HUMAN IMMUNODEFICIENCY VIRUS HIV-1
1RT7 1999-07-29 3.0 HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC84
1SUQ 2004-05-11 3.0 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R185545
1N6Q 2003-01-14 3.0 HIV-1 Reverse Transcriptase Crosslinked to pre-translocation AZTMP-terminated DNA (complex N)
1DTT 2000-04-02 3.0 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-2 (PETT130A94)
5I3U 2016-06-01 3.0 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE N-SITE COMPLEX; CATALYTIC INCORPORATION OF AZTMP to A DNA aptamer in CRYSTAL
1E28 2000-09-12 3.0 Nonstandard peptide binding of HLA-B*5101 complexed with HIV immunodominant epitope KM2(TAFTIPSI)
1JLC 2001-10-03 3.0 CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-2
1S6Q 2004-05-11 3.0 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R147681
1IKV 2001-06-06 3.0 K103N Mutant HIV-1 Reverse Transcriptase in Complex with Efivarenz
1HPZ 2001-05-30 3.0 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
1RT3 1999-02-16 3.0 AZT DRUG RESISTANT HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH 1051U91
2IC3 2006-12-19 3.0 Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with Nonnucleoside Inhibitor HBY 097
1HYS 2001-03-26 3.0 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A POLYPURINE TRACT RNA:DNA
4PWD 2014-06-18 3.0 Crystal structure of HIV-1 reverse transcriptase in complex with bulge-RNA/DNA and Nevirapine
5UV5 2017-08-16 3.0 Crystal Structure of a 2-Hydroxyisoquinoline-1,3-dione RNase H Active Site Inhibitor with Multiple Binding Modes to HIV Reverse Transcriptase
1JLQ 2001-08-22 3.0 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH 739W94
1HNV 1995-07-10 3.0 STRUCTURE OF HIV-1 RT(SLASH)TIBO R 86183 COMPLEX REVEALS SIMILARITY IN THE BINDING OF DIVERSE NONNUCLEOSIDE INHIBITORS
4U0D 2014-11-12 3.0 Hexameric HIV-1 CA in complex with Nup153 peptide, P212121 crystal form
1TVR 1997-03-12 3.0 HIV-1 RT/9-CL TIBO
5W5W 2018-06-20 3.0 HIV Protease (PR) in open form with Mg2+ in active site and HIVE-9 in eye site
4RW7 2015-04-29 3.01 Crystal Structure of HIV-1 Reverse Transcriptase (K103N, Y181C) variant in complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ532), a non-nucleoside inhibitor
2VG6 2007-12-11 3.01 Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors
6CQR 2018-06-06 3.04 Crystal structure of F24 TCR -DR1-RQ13 peptide complex
5HBM 2016-02-24 3.04 Crystal Structure of a Dihydroxycoumarin RNase H Active-Site Inhibitor in Complex with HIV-1 Reverse Transcriptase
3GGV 2009-05-26 3.09 HIV Protease, pseudo-symmetric inhibitors
1FQX 2001-03-14 3.1 CRYSTAL STRUCTURE OF THE COMPLEX OF HIV-1 PROTEASE WITH A PEPTIDOMIMETIC INHIBITOR
3KJV 2010-03-23 3.1 HIV-1 reverse transcriptase in complex with DNA
5FDL 2016-02-17 3.1 Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with IDX899
5HGL 2016-08-10 3.1 Hexameric HIV-1 CA, open conformation
5TEP 2017-01-11 3.1 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ649), a Non-nucleoside Inhibitor
1T03 2004-05-11 3.1 HIV-1 reverse transcriptase crosslinked to tenofovir terminated template-primer (complex P)
1N5Y 2003-01-28 3.1 HIV-1 Reverse Transcriptase Crosslinked to Post-Translocation AZTMP-Terminated DNA (Complex P)
1BQM 1999-01-06 3.1 HIV-1 RT/HBY 097
4LSN 2013-12-25 3.1 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-bromo-5-(4-chloro-2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ518), a non-nucleoside inhibitor
3W39 2013-02-13 3.1 Crystal structure of HLA-B*5201 in complexed with HIV immunodominant epitope (TAFTIPSI)
3DRS 2008-10-14 3.15 HIV reverse transcriptase K103N mutant in complex with inhibitor R8D
3KLF 2010-09-22 3.15 Crystal structure of wild-type HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA
2I5J 2006-12-05 3.15 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with DHBNH, an RNASE H inhibitor
1RTD 1998-12-09 3.2 STRUCTURE OF A CATALYTIC COMPLEX OF HIV-1 REVERSE TRANSCRIPTASE: IMPLICATIONS FOR NUCLEOSIDE ANALOG DRUG RESISTANCE
1UWB 1997-05-15 3.2 TYR 181 CYS HIV-1 RT/8-CL TIBO
1HMV 1995-03-31 3.2 THE STRUCTURE OF UNLIGANDED REVERSE TRANSCRIPTASE FROM THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
2WOM 2010-08-11 3.2 Crystal Structure of UK-453061 bound to HIV-1 Reverse Transcriptase (K103N).
3KLE 2010-09-22 3.2 Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA
6BSI 2018-01-03 3.25 Structure of HIV-1 RT complexed with an RNA/DNA hybrid containing the polypurine-tract sequence
4Q0B 2014-06-18 3.3 Crystal structure of HIV-1 reverse transcriptase in complex with gap-RNA/DNA and Nevirapine
1BQN 1999-01-06 3.3 TYR 188 LEU HIV-1 RT/HBY 097
3JYT 2009-10-06 3.3 K65R mutant HIV-1 reverse transcriptase cross-linked to DS-DNA and complexed with DATP as the incoming nucleotide substrate
4B3O 2013-01-16 3.3 Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface
5I42 2016-06-01 3.3 Structure of HIV-1 Reverse Transcriptase in complex with a DNA aptamer, AZTTP, and CA(2+) ion
6BJ2 2018-07-25 3.35 TCR589 in complex with HIV(Pol448-456)/HLA-B35
1P7Q 2003-10-14 3.4 Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor
5C42 2015-11-11 3.5 Crystal Structure of HIV-1 Reverse Transcriptase (K101P) Variant in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)indolizine-2-carbonitrile (JLJ555), a non-nucleoside inhibitor
1J5O 2002-06-14 3.5 CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE-PRIMER
3KLG 2010-09-22 3.65 Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to pre-translocation AZTMP-Terminated DNA (COMPLEX N)
1AFV 1997-08-20 3.7 HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3
5L93 2016-07-13 3.9 An atomic model of HIV-1 CA-SP1 reveals structures regulating assembly and maturation
6HAK 2019-04-03 3.95 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with a double stranded RNA represents the RT transcription initiation complex prior to nucleotide incorporation
3DTJ 2008-09-02 4.0 HIV-1 capsid C-terminal domain mutant (E187A)
6B19 2018-04-25 4.5 Architecture of HIV-1 reverse transcriptase initiation complex core
1HVU 1999-01-13 4.75 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE COMPLEXED WITH A 33-BASE NUCLEOTIDE RNA PSEUDOKNOT
4B3P 2013-01-16 4.84 Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface
5UPW 2017-03-01 5.0 CryoEM Structure Refinement by Integrating NMR Chemical Shifts with Molecular Dynamics Simulations
4B3Q 2013-01-16 5.0 Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface
3P0A 2011-01-12 5.95 X-ray structure of pentameric HIV-1 CA
3GV2 2009-06-23 7.0 X-ray Structure of Hexameric HIV-1 CA

Relevant UniProtKB Entries

Percent Identity Matching Chains Protein Accession Entry Name
97.3 Gag-Pol polyprotein P04586 POL_HV1Z6
93.1 Gag-Pol polyprotein P05889 GAG_HV1W2
92.2 Gag-Pol polyprotein P12493 GAG_HV1N5
93.8 Gag-Pol polyprotein P12498 POL_HV1J3
94.4 Gag-Pol polyprotein P05960 POL_HV1C4
92.8 Gag-Pol polyprotein P04589 POL_HV1EL
93.2 Gag-Pol polyprotein P05961 POL_HV1MN
93.7 Gag-Pol polyprotein P18802 POL_HV1ND
93.9 Gag-Pol polyprotein P12499 POL_HV1Z2
94.6 Gag-Pol polyprotein P05959 POL_HV1RH
94.4 Gag-Pol polyprotein P04587 POL_HV1B5
94.4 Gag-Pol polyprotein P20875 POL_HV1JR
96.1 Gag-Pol polyprotein P03369 POL_HV1A2
94.5 Gag-Pol polyprotein P03366 POL_HV1B1
95.0 Gag-Pol polyprotein P03367 POL_HV1BR
96.2 Gag-Pol polyprotein Q73368 POL_HV1B9
95.3 Gag-Pol polyprotein P20892 POL_HV1OY
95.5 Gag-Pol polyprotein P0C6F2 POL_HV1LW
95.5 Gag-Pol polyprotein P04585 POL_HV1H2
97.0 Gag-Pol polyprotein P35963 POL_HV1Y2
100.0 Gag-Pol polyprotein P12497 POL_HV1N5