The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing.


Abstract

Viral immune evasion by sequence variation is a major hindrance to HIV-1 vaccine design. To address this challenge, our group has developed a computational model, rooted in physics, that aims to predict the fitness landscape of HIV-1 proteins in order to design vaccine immunogens that lead to impaired viral fitness, thus blocking viable escape routes. Here, we advance the computational models to address previous limitations, and directly test model predictions against in vitro fitness measurements of HIV-1 strains containing multiple Gag mutations. We incorporated regularization into the model fitting procedure to address finite sampling. Further, we developed a model that accounts for the specific identity of mutant amino acids (Potts model), generalizing our previous approach (Ising model) that is unable to distinguish between different mutant amino acids. Gag mutation combinations (17 pairs, 1 triple and 25 single mutations within these) predicted to be either harmful to HIV-1 viability or fitness-neutral were introduced into HIV-1 NL4-3 by site-directed mutagenesis and replication capacities of these mutants were assayed in vitro. The predicted and measured fitness of the corresponding mutants for the original Ising model (r = -0.74, p = 3.6×10-6) are strongly correlated, and this was further strengthened in the regularized Ising model (r = -0.83, p = 3.7×10-12). Performance of the Potts model (r = -0.73, p = 9.7×10-9) was similar to that of the Ising model, indicating that the binary approximation is sufficient for capturing fitness effects of common mutants at sites of low amino acid diversity. However, we show that the Potts model is expected to improve predictive power for more variable proteins. Overall, our results support the ability of the computational models to robustly predict the relative fitness of mutant viral strains, and indicate the potential value of this approach for understanding viral immune evasion, and harnessing this knowledge for immunogen design.

Submission Details

ID: LKkeX8UC4

Submitter: Connie Wang

Submission Date: Oct. 22, 2018, 10:46 a.m.

Version: 1

Publication Details
Mann JK;Barton JP;Ferguson AL;Omarjee S;Walker BD;Chakraborty A;Ndung'u T,PLoS Comput Biol (2014) The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing. PMID:25102049
Additional Information

Study Summary

Number of data points 38
Proteins Gag-Pol polyprotein
Unique complexes 38
Assays/Quantities/Protocols Experimental Assay: Replication capacity ratio
Libraries Supplmental Table 1: Replication Capacity of Gag p24

Structure view and single mutant data analysis

Study data

No weblogo for data of varying length.
Colors: D E R H K S T N Q A V I L M F Y W C G P
 

Data Distribution

Studies with similar sequences (approximate matches)

Correlation with other assays (exact sequence matches)


Relevant PDB Entries

Structure ID Release Date Resolution Structure Title
2L6E 2010-12-29 NMR Structure of the monomeric mutant C-terminal domain of HIV-1 Capsid in complex with stapled peptide Inhibitor
2LYA 2013-02-13 Structure of HIV-1 myr(-) matrix protein in complex with 1,2-dioctanoyl-sn-phosphatidylcholine
6X63 2020-09-02 Atomic-Resolution Structure of HIV-1 Capsid Tubes by Magic Angle Spinning NMR
1QMC 1999-12-14 C-terminal DNA-binding domain of HIV-1 integrase, NMR, 42 structures
2JZW 2009-01-13 How the HIV-1 nucleocapsid protein binds and destabilises the (-)primer binding site during reverse transcription
1Q9P 2004-03-02 Solution structure of the mature HIV-1 protease monomer
2H3I 2006-07-25 Solution structure of the HIV-1 myristoylated Matrix protein
1ESK 2000-04-26 SOLUTION STRUCTURE OF NCP7 FROM HIV-1
2MGU 2014-02-12 Structure of the complex between calmodulin and the binding domain of HIV-1 matrix protein
2H3Q 2006-07-25 Solution structure of HIV-1 myrMA bound to di-C4-phosphatidylinositol-(4,5)-bisphosphate
1WJC 1998-05-13 SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (E FORM), NMR, REGULARIZED MEAN STRUCTURE
1NCP 1993-10-31 STRUCTURAL CHARACTERIZATION OF A 39 RESIDUE SYNTHETIC PEPTIDE CONTAINING THE TWO ZINC BINDING DOMAINS FROM THE HIV-1 P7 NUCLEOCAPSID PROTEIN BY CD AND NMR SPECTROSCOPY
1WJA 1998-05-13 SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (D FORM), NMR, REGULARIZED MEAN STRUCTURE
1BVE 1996-08-17 HIV-1 PROTEASE-DMP323 COMPLEX IN SOLUTION, NMR, 28 STRUCTURES
2L45 2011-12-14 C-terminal zinc knuckle of the HIVNCp7 with DNA
2H3Z 2006-07-25 Structure of the HIV-1 matrix protein bound to di-C4-phosphatidylinositol-(4,5)-bisphosphate
2EXF 2007-04-24 Solution structure of the HIV-1 nucleocapsid (NCp7(12-55)) complexed with the DNA (-) Primer Binding Site
3DIK 2008-09-16 Pseudo-atomic model of the HIV-1 CA hexameric lattice
2H3F 2006-07-25 Solution structure of the HIV-1 MA protein
5IRT 2016-06-22 Dimerization interface of the noncrystalline HIV-1 capsid protein lattice from solid state NMR spectroscopy of tubular assemblies
5T82 2017-01-18 HIV-1 reverse transcriptase thumb subdomain
6WAP 2020-09-02 Atomic-Resolution Structure of HIV-1 Capsid Tubes by Magic Angle Spinning NMR
2M3Z 2013-02-27 NMR solution structure of HIV-1 nucleocapsid protein in complex with an inhibitor displaying a 2 inhibitors:1 NC stoichiometry
1WJE 1998-12-16 SOLUTION STRUCTURE OF H12C MUTANT OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE COMPLEXED TO CADMIUM, NMR, MINIMIZED AVERAGE STRUCTURE
2JYL 2008-02-12 Solution Structure of A Double Mutant of The Carboxy-terminal Dimerization Domain of The HIV-1 Capsid Protein
1IHV 1996-10-14 SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, MINIMIZED AVERAGE STRUCTURE
2M8L 2013-11-20 HIV capsid dimer structure
1O1W 2003-02-18 SOLUTION STRUCTURE OF THE RNASE H DOMAIN OF THE HIV-1 REVERSE TRANSCRIPTASE IN THE PRESENCE OF MAGNESIUM
1AAF 1994-01-31 NUCLEOCAPSID ZINC FINGERS DETECTED IN RETROVIRUSES: EXAFS STUDIES ON INTACT VIRUSES AND THE SOLUTION-STATE STRUCTURE OF THE NUCLEOCAPSID PROTEIN FROM HIV-1
2LF4 2011-11-09 Structure of a monomeric mutant of the HIV-1 capsid protein
1BVG 1996-08-17 HIV-1 PROTEASE-DMP323 COMPLEX IN SOLUTION, NMR MINIMIZED AVERAGE STRUCTURE
2LYB 2013-02-13 Structure of HIV-1 myr(-) matrix protein in complex with 1,2-dioctanoyl-sn-phosphatidyl-L-serine
1IHW 1996-07-11 SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 40 STRUCTURES
2H3V 2006-07-25 Structure of the HIV-1 Matrix protein bound to di-C8-phosphatidylinositol-(4,5)-bisphosphate
2JYG 2008-02-26 Solution Structure of the W184A/M185A Mutant of the Carboxy-terminal Dimerization Domain of the HIV-1 Capsid Protein
2M8P 2013-11-20 The structure of the W184AM185A mutant of the HIV-1 capsid protein
2L4L 2010-12-08 Structural insights into the cTAR DNA recognition by the HIV-1 Nucleocapsid protein: role of sugar deoxyriboses in the binding polarity of NC
1UPH 2004-01-08 HIV-1 Myristoylated Matrix
5E5K 2016-05-04 Joint X-ray/neutron structure of HIV-1 protease triple mutant (V32I,I47V,V82I) with darunavir at pH 4.3
2L46 2011-12-14 C-terminal zinc finger of the HIVNCp7 with platinated DNA
2M8N 2013-11-20 HIV-1 capsid monomer structure
2C55 2005-11-02 Solution Structure of the Human Immunodeficiency Virus Type 1 p6 Protein
1TAM 1996-07-11 HUMAN IMMUNODEFICIENCY VIRUS, NMR, MINIMIZED AVERAGE STRUCTURE
1WJB 1998-05-13 SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (D FORM), NMR, 40 STRUCTURES
4JEC 2013-07-24 Joint neutron and X-ray structure of per-deuterated HIV-1 protease in complex with clinical inhibitor amprenavir
1MFS 1998-06-17 DYNAMICAL BEHAVIOR OF THE HIV-1 NUCLEOCAPSID PROTEIN; NMR, 30 STRUCTURES
2HMX 1996-01-29 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 MATRIX PROTEIN
1WJD 1998-05-13 SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (E FORM), NMR, 38 STRUCTURES
2KOD 2009-11-24 A high-resolution NMR structure of the dimeric C-terminal domain of HIV-1 CA
1WJF 1998-12-16 SOLUTION STRUCTURE OF H12C MUTANT OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE COMPLEXED TO CADMIUM, NMR, 40 STRUCTURES
6RWG 2020-05-20 Structure of HIV-1 CAcSP1NC mutant(W41A,M42A) interacting with maturation inhibitor EP39
1GWP 2002-06-21 STRUCTURE OF THE N-TERMINAL DOMAIN OF THE MATURE HIV-1 CAPSID PROTEIN
2JPR 2007-10-09 Joint refinement of the HIV-1 CA-NTD in complex with the assembly inhibitor CAP-1
1F6U 2000-10-09 NMR structure of the HIV-1 nucleocapsid protein bound to stem-loop sl2 of the psi-RNA packaging signal. Implications for genome recognition
5YOK 2018-07-18 0.85 Structure of HIV-1 Protease in Complex with Inhibitor KNI-1657
3A2O 2010-03-02 0.88 Crystal Structure of HIV-1 Protease Complexed with KNI-1689
3FX5 2009-03-24 0.93 Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by High Resolution X-ray Crystallography
3DJK 2008-09-30 1.0 Wild Type HIV-1 Protease with potent Antiviral inhibitor GRL-0255A
3NU3 2010-08-25 1.02 Wild Type HIV-1 Protease with Antiviral Drug Amprenavir
1NH0 2004-04-13 1.03 1.03 A structure of HIV-1 protease: inhibitor binding inside and outside the active site
3NDX 2011-07-20 1.03 HIV-1 Protease Saquinavir:Ritonavir 1:50 complex structure
2J9J 2007-08-28 1.04 Atomic-resolution Crystal Structure of Chemically-Synthesized HIV-1 Protease Complexed with Inhibitor JG-365
3D20 2008-05-27 1.05 Crystal structure of HIV-1 mutant I54V and inhibitor DARUNAVIA
3BVA 2008-04-01 1.05 Cystal structure of HIV-1 Active Site Mutant D25N and p2-NC analog inhibitor
3D1X 2008-06-03 1.05 Crystal structure of HIV-1 mutant I54M and inhibitor saquinavir
3D1Y 2008-05-27 1.05 Crystal structure of HIV-1 mutant I54V and inhibitor SAQUINA
4HE9 2013-08-21 1.06 Crystal Structure of HIV-1 protease mutants I54M complexed with inhibitor GRL-0519
2JE4 2007-08-28 1.07 Atomic-resolution crystal structure of chemically-synthesized HIV-1 protease in complex with JG-365
3DK1 2009-05-12 1.07 Wild Type HIV-1 Protease with potent Antiviral inhibitor GRL-0105A
1KZK 2002-04-03 1.09 JE-2147-HIV Protease Complex
2AVO 2006-01-24 1.1 Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S
2AVM 2006-01-24 1.1 Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S
2AVS 2006-01-24 1.1 kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, and G73S
2AOG 2006-01-17 1.1 Crystal structure analysis of HIV-1 protease mutant V82A with a substrate analog P2-NC
4EJD 2013-05-01 1.1 HIV Protease (PR) dimer in closed form with pepstatin in active site and fragment 1F1 in the outside/top of flap
4ZIP 2015-07-15 1.11 HIV-1 wild Type protease with GRL-0648A (a isophthalamide-derived P2-Ligand)
2QD7 2008-04-22 1.11 HIV-1 Protease Mutant V82A with potent Antiviral inhibitor GRL-98065
3TOH 2012-08-15 1.12 HIV-1 Protease - Epoxydic Inhibitor Complex (pH 9 - Orthorombic Crystal form P212121)
3DS4 2008-09-02 1.12 HIV-1 capsid C-terminal domain mutant (L211S) in complex with an inhibitor of particle assembly (CAI)
6DV4 2018-10-31 1.14 HIV-1 wild type protease with GRL-04315A, a tetrahydronaphthalene carboxamide with (R)-Boc-amine and (S)-hydroxyl functionalities as the P2 ligand
3NDW 2011-07-20 1.14 HIV-1 Protease Saquinavir:Ritonavir 1:15 complex structure
5JG1 2016-09-21 1.16 HIV-1 wild Type protease with GRL-031-14A (a Adamantane P1-Ligand with tetrahydropyrano-tetrahydrofuran in P2 and isobutylamine in P1')
3NU6 2010-08-25 1.16 Crystal Structure of HIV-1 Protease Mutant I54M with Antiviral Drug Amprenavir
3I6O 2009-09-29 1.17 Crystal structure of wild type HIV-1 protease with macrocyclic inhibitor GRL-0216A
6VCE 2020-07-01 1.18 HIV-1 wild type protease with GRL-026-18A, a crown-like tetrahydropyranotetrahydrofuran with a bridged methylene group as a P2 ligand
4MC9 2014-04-02 1.19 HIV protease in complex with AA74
6DIF 2018-10-17 1.2 Wild-type HIV-1 protease in complex with tipranavir
1K1T 2002-07-10 1.2 Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
6DV0 2018-10-31 1.2 HIV-1 wild type protease with GRL-02815A, a thiochroman heterocycle with (S)-Boc-amine functionality as the P2 ligand
2QCI 2008-04-22 1.2 HIV-1 Protease mutant D30N with potent Antiviral inhibitor GRL-98065
1T3R 2005-05-03 1.2 HIV protease wild-type in complex with TMC114 inhibitor
2J9K 2007-08-28 1.2 Atomic-resolution Crystal Structure of Chemically-Synthesized HIV-1 Protease Complexed with Inhibitor MVT-101
5AGZ 2015-05-06 1.2 Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
4FL8 2012-10-17 1.2 HIV-1 protease complexed with gem-diol-amine tetrahedral intermediate
3CYX 2008-05-27 1.2 Crystal structure of HIV-1 mutant I50V and inhibitor saquinavira
3NU4 2010-08-25 1.2 Crystal Structure of HIV-1 Protease Mutant V32I with Antiviral Drug Amprenavir
3DS2 2008-09-02 1.2 HIV-1 capsid C-terminal domain mutant (Y169A)
6PRF 2019-09-18 1.21 HIV-1 Protease multiple drug resistant clinical isolate mutant PR20 with GRL-14213A
5DGU 2015-10-28 1.22 Crystal Structure of HIV-1 Protease Inhibitors Containing Substituted fused-Tetrahydropyranyl Tetrahydrofuran as P2-Ligand GRL-004-11A
2F8G 2006-03-07 1.22 HIV-1 protease mutant I50V complexed with inhibitor TMC114
4HDP 2013-08-14 1.22 Crystal Structure of HIV-1 protease mutants I50V complexed with inhibitor GRL-0519
6E9A 2018-11-07 1.22 HIV-1 WILD TYPE PROTEASE WITH GRL-034-17A, (3aS, 5R, 6aR)-2-OXOHEXAHYD CYCLOPENTA[D]-5-OXAZOLYL URETHANE WITH A BICYCLIC OXAZOLIDINONE SCAFF AS THE P2 LIGAND
4DFG 2012-03-21 1.23 Crystal Structure of Wild-type HIV-1 Protease with Cyclopentyltetrahydro- furanyl Urethanes as P2-ligand, GRL-0249A
3TOG 2012-08-15 1.24 HIV-1 Protease - Epoxydic Inhibitor Complex (pH 9 - Monoclinic Crystal form P21)
3VF5 2012-11-21 1.25 Crystal Structure of HIV-1 Protease Mutant I47V with novel P1'-Ligands GRL-02031
1SDU 2004-05-25 1.25 Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site.
3NDU 2011-07-20 1.25 HIV-1 Protease Saquinavir:Ritonavir 1:5 complex structure
2F81 2006-03-07 1.25 HIV-1 Protease mutant L90M complexed with inhibitor TMC114
6VOD 2020-05-13 1.25 HIV-1 wild type protease with GRL-052-16A, a tricyclic cyclohexane fused tetrahydrofuranofuran (CHf-THF) derivative as the P2 ligand
5AH8 2015-05-06 1.26 Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
6DJ1 2018-10-17 1.26 Wild-type HIV-1 protease in complex with Lopinavir
5UPZ 2017-05-10 1.27 HIV-1 wild Type protease with GRL-0518A , an isophthalamide-derived P2-P3 ligand with the para-hydoxymethyl sulfonamide isostere as the P2' group
3OK9 2010-09-22 1.27 Crystal structure of wild-type HIV-1 protease with new oxatricyclic designed inhibitor GRL-0519A
2QD6 2008-04-22 1.28 HIV-1 Protease Mutant I50V with potent Antiviral inhibitor GRL-98065
3NU5 2010-08-25 1.29 Crystal Structure of HIV-1 Protease Mutant I50V with Antiviral Drug Amprenavir
4HDF 2013-08-14 1.29 Crystal Structure of HIV-1 protease mutants V82A complexed with inhibitor GRL-0519
3H5B 2009-06-16 1.29 Crystal structure of wild type HIV-1 protease with novel P1'-ligand GRL-02031
5BS4 2015-09-09 1.29 HIV-1 wild Type protease with GRL-047-11A (a methylamine bis-Tetrahydrofuran P2-Ligand, 4-amino sulfonamide derivative)
6VOE 2020-05-13 1.3 HIV-1 wild type protease with GRL-019-17A, a tricyclic cyclohexane fused tetrahydrofuranofuran (CHf-THF) derivative as the P2 ligand and a aminobenzothiazole(Abt)-based P2'-ligand
4YHQ 2015-06-10 1.3 Crystal structure of multidrug resistant clinical isolate PR20 with GRL-5010A
6T6E 2020-07-22 1.3 Crystal Structure of the C-terminal domain of the HIV-1 Integrase (PNL4-3)
4U8W 2014-11-05 1.3 HIV-1 wild Type protease with GRL-050-10A (a Gem-difluoro-bis-Tetrahydrofuran as P2-Ligand)
2AVQ 2006-01-24 1.3 Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S
2A1E 2006-02-21 1.3 High resolution structure of HIV-1 PR with TS-126
4DQE 2012-03-07 1.3 Crystal Structure of (G16C/L38C) HIV-1 Protease in Complex with DRV
2IEN 2006-10-03 1.3 Crystal structure analysis of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017)
3HAW 2011-04-27 1.3 Crystal structure of [L-Ala51/51']HIV-1 protease with reduced isostere MVT-101 inhibitor
1SDT 2004-05-25 1.3 Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site.
3HAU 2011-04-27 1.3 Crystal structure of chemically synthesized HIV-1 protease with reduced isostere MVT-101 inhibitor
3VF7 2012-11-21 1.3 Crystal Structure of HIV-1 Protease Mutant L76V with novel P1'-Ligands GRL-02031
3KFR 2010-02-23 1.3 HIV Protease (PR) dimer with inhibitor TL-3 bound and fragment 1F1 in the outside/top of flap
6E7J 2018-11-07 1.3 HIV-1 wild type protease with GRL-042-17A, 3-phenylhexahydro-2h-cyclopenta[d]oxazol-2-one with a bicyclic oxazolidinone scaffold as the P2 ligand
3BVB 2008-04-01 1.3 Cystal structure of HIV-1 Active Site Mutant D25N and inhibitor Darunavir
3D1Z 2008-05-27 1.3 Crystal structure of HIV-1 mutant I54M and inhibitor DARUNAVIR
2AOC 2006-01-17 1.3 Crystal structure analysis of HIV-1 protease mutant I84V with a substrate analog P2-NC
4FLG 2012-10-17 1.31 HIV-1 protease mutant I47V complexed with reaction intermediate
6DJ7 2018-10-17 1.31 HIV-1 protease with mutation L76V in complex with GRL-5010 (gem-difluoro-bis-tetrahydrofuran as P2 ligand)
4MC6 2014-04-02 1.31 HIV protease in complex with SA499
6KMP 2020-07-29 1.31 100K X-ray structure of HIV-1 protease triple mutant (V32I,I47V,V82I) with tetrahedral intermediate mimic KVS-1
4J55 2013-05-15 1.31 Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical isolate PR20 with the potent antiviral inhibitor GRL-02031
2AOF 2006-01-17 1.32 Crystal structure analysis of HIV-1 Protease mutant V82A with a substrate analog P1-P6
3TL9 2012-04-25 1.32 crystal structure of HIV protease model precursor/Saquinavir complex
5UOV 2017-05-10 1.33 HIV-1 wild Type protease with GRL-1118A , an isophthalamide-derived P2-P3 ligand with the sulfonamide isostere as the P2' group
2O4L 2006-12-12 1.33 Crystal Structure of HIV-1 Protease (Q7K, I50V) in Complex with Tipranavir
5BRY 2015-09-09 1.34 HIV-1 wild Type protease with GRL-011-11A (a methylamine bis-Tetrahydrofuran P2-Ligand, sulfonamide isostere derivate)
3TH9 2011-09-28 1.34 Crystal Structure of HIV-1 Protease Mutant Q7K V32I L63I with a cyclic sulfonamide inhibitor
1T7I 2005-05-10 1.35 The structural and thermodynamic basis for the binding of TMC114, a next-generation HIV-1 protease inhibitor.
3NUO 2010-08-25 1.35 Crystal Structure of HIV-1 Protease Mutant L90M with Antiviral Drug Amprenavir
4YE3 2015-06-10 1.35 Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 with Inhibitor GRL-4410A
2BB9 2005-11-15 1.35 Structure of HIV1 protease and AKC4p_133a complex.
5AHA 2015-05-06 1.35 Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
2QD8 2008-04-22 1.35 HIV-1 Protease Mutant I84V with potent Antiviral inhibitor GRL-98065
3TKG 2012-04-25 1.36 crystal structure of HIV model protease precursor/saquinavir complex
6DJ2 2018-10-17 1.36 HIV-1 protease with single mutation L76V in complex with Lopinavir
3QN8 2012-02-08 1.38 HIV-1 protease (mutant Q7K L33I L63I) in complex with a novel inhibitor
4U7V 2015-03-25 1.38 Structure of wild-type HIV protease in complex with degraded photosensitive inhibitor
4U1J 2015-04-08 1.38 HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential HIV-1 escape through identical epitopes
3UCB 2012-03-28 1.38 Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Darunavir
3QIH 2012-02-01 1.39 HIV-1 protease (mutant Q7K L33I L63I) in complex with a novel inhibitor
3K4V 2010-06-09 1.39 New crystal form of HIV-1 Protease/Saquinavir structure reveals carbamylation of N-terminal proline
4MC1 2014-04-02 1.39 HIV protease in complex with SA526P
2AOD 2006-01-17 1.4 Crystal structure analysis of HIV-1 protease with a substrate analog P2-NC
3CYW 2008-05-27 1.4 Effect of Flap Mutations on Structure of HIV-1 Protease and Inhibition by Saquinavir and Darunavir
2AOI 2006-01-17 1.4 Crystal structure analysis of HIV-1 protease with a substrate analog P1-P6
4FM6 2012-10-17 1.4 HIV-1 protease mutant V32I complexed with reaction intermediate
3QIO 2011-04-20 1.4 Crystal Structure of HIV-1 RNase H with engineered E. coli loop and N-hydroxy quinazolinedione inhibitor
2XDE 2010-12-22 1.4 Crystal structure of the complex of PF-3450074 with an engineered HIV capsid N terminal domain
3QAA 2011-12-21 1.4 HIV-1 wild type protease with a substituted bis-Tetrahydrofuran inhibitor, GRL-044-10A
1SDV 2004-05-25 1.4 Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site.
3KA2 2011-04-27 1.4 Crystal structure of chemically synthesized 203 amino acid 'covalent dimer' [L-Ala;Gly51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.4 A resolution
2QNP 2008-04-15 1.41 HIV-1 Protease in complex with a iodo decorated pyrrolidine-based inhibitor
2AOH 2006-01-17 1.42 Crystal structure analysis of HIV-1 Protease mutant V82A with a substrate analog P6-PR
3VFA 2012-11-21 1.43 Crystal Structure of HIV-1 Protease Mutant V82A with novel P1'-Ligands GRL-02031
2FNT 2006-09-05 1.44 Crystal structure of a drug-resistant (V82A) inactive (D25N) HIV-1 protease complexed with AP2V variant of HIV-1 NC-p1 substrate.
5AH9 2015-05-06 1.44 Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
2F80 2006-03-07 1.45 HIV-1 Protease mutant D30N complexed with inhibitor TMC114
3ST5 2011-08-17 1.45 Crystal structure of wild-type HIV-1 protease with C3-Substituted Hexahydrocyclopentafuranyl Urethane as P2-Ligand, GRL-0489A
3PWR 2011-04-20 1.45 HIV-1 Protease Mutant L76V complexed with Saquinavir
3QP0 2012-02-15 1.45 HIV-1 protease (mutant Q7K L33I L63I) in complex with a novel inhibitor
3TOF 2012-08-15 1.45 HIV-1 Protease - Epoxydic Inhibitor Complex (pH 6 - Orthorombic Crystal form P212121)
3QBF 2012-01-18 1.45 HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor
3WNF 2013-12-25 1.45 Cyclic hexapeptide CKIDNC in complex with HIV-1 integrase
3NYG 2011-11-02 1.45 X-ray structure of ester chemical analogue [O-Gly51,O-Gly51']HIV-1 protease complexed with MVT-101 inhibitor
3O9I 2011-08-10 1.45 Crystal Structure of wild-type HIV-1 Protease in complex with af61
3UFN 2012-03-28 1.45 Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Saquinavir
6O48 2019-06-19 1.46 Wild-type HIV-1 protease in complex with a substrate analog CA-p2
6OYD 2020-05-20 1.46 X-ray crystal structure of wild type HIV-1 protease in complex with GRL-004
3B7V 2007-12-18 1.46 HIV-1 protease complexed with gem-diol-amine tetrahedral intermediate NLLTQI
4HEG 2013-08-21 1.46 Crystal Structure of HIV-1 protease mutants R8Q complexed with inhibitor GRL-0519
6B3F 2018-01-03 1.46 Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,5S)-5-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide
3PWM 2011-04-20 1.46 HIV-1 Protease Mutant L76V with Darunavir
2QNN 2008-04-15 1.48 HIV-1 protease in complex with a multiple decorated pyrrolidine-based inhibitor
6DIL 2018-10-17 1.48 HIV-1 protease with single mutation L76V in complex with tipranavir
6MCR 2019-04-24 1.48 X-ray crystal structure of wild type HIV-1 protease in complex with GRL-001
6B38 2018-01-03 1.48 Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,6R)-6-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide
4HDB 2013-08-14 1.49 Crystal Structure of HIV-1 protease mutants D30N complexed with inhibitor GRL-0519
5JFP 2016-09-21 1.49 HIV-1 wild Type protease with GRL-097-13A (a Adamantane P1-Ligand with bis-THF in P2 and isobutylamine in P1')
5YOJ 2018-07-11 1.5 Structure of A17 HIV-1 Protease in Complex with Inhibitor KNI-1657
4NX4 2014-02-26 1.5 Re-refinement of CAP-1 HIV-CA complex
2FGV 2006-11-07 1.5 X-ray crystal structure of HIV-1 Protease T80N variant in complex with the inhibitor saquinavir used to explore the role of invariant Thr80 in HIV-1 protease structure, function, and viral infectivity.
1XL2 2005-06-07 1.5 HIV-1 Protease in complex with pyrrolidinmethanamine
5AH6 2015-05-06 1.5 Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
5AHB 2015-05-06 1.5 Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
3WNH 2013-12-25 1.5 Cyclic hexapeptide PKZDNv in complex with HIV-1 integrase
2PWR 2008-04-15 1.5 HIV-1 protease in complex with a carbamoyl decorated pyrrolidine-based inhibitor
3NWQ 2011-11-02 1.5 X-ray structure of ester chemical analogue [O-Ile50,O-Ile50']HIV-1 protease complexed with MVT-101
3NUJ 2010-08-25 1.5 Crystal Structure of HIV-1 Protease Mutant I54V with Antiviral Drug Amprenavir
4QJ6 2014-10-29 1.5 Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with p1-p6 substrate variant (L449F)
6B3G 2018-01-03 1.5 Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,6S)-6-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide
4Q1Y 2015-02-18 1.5 Mutations Outside the Active Site of HIV-1 Protease Alter Enzyme Structure and Dynamic Ensemble of the Active Site to Confer Drug Resistance
4DQB 2012-03-07 1.5 Crystal Structure of wild-type HIV-1 Protease in Complex with DRV
6J1W 2019-09-25 1.5 The structure of HLA-A*3001/RT313
3B80 2007-12-18 1.5 HIV-1 protease mutant I54V complexed with gem-diol-amine intermediate NLLTQI
2AVV 2006-01-24 1.5 Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, and G73S
5AHC 2015-05-06 1.5 Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
4A6C 2012-05-09 1.5 Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based HIV-1 Protease Inhibitors
4G1Q 2013-02-06 1.51 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with Rilpivirine (TMC278, Edurant), a non-nucleoside rt-inhibiting drug
6PYL 2019-11-27 1.52 Crystal Structure of HLA-B*2703 in complex with KK10, an HIV peptide
6MCS 2019-04-24 1.52 X-ray crystal structure of wild type HIV-1 protease in complex with GRL-003
5ULT 2017-05-03 1.53 HIV-1 wild Type protease with GRL-100-13A (a Crown-like Oxotricyclic Core as the P2-Ligand with the sulfonamide isostere as the P2' group)
4ZLS 2015-07-15 1.53 HIV-1 wild Type protease with GRL-096-13A (a Boc-derivative P2-Ligand, 3,-5-dimethylbiphenyl P1-Ligand)
6OYR 2020-05-20 1.54 X-ray crystal structure of wild type HIV-1 protease in complex with GRL-002
4QJA 2014-10-29 1.54 Crystal structure of inactive HIV-1 protease in complex with p1-p6 substrate variant (P453L)
4E43 2012-05-30 1.54 HIV protease (PR) dimer with acetate in exo site and peptide in active site
2AOE 2006-01-17 1.54 crystal structure analysis of HIV-1 protease mutant V82A with a substrate analog CA-P2
3ZPT 2013-11-06 1.54 Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors
2O4S 2006-12-12 1.54 Crystal Structure of HIV-1 Protease (Q7K) in Complex with Lopinavir
3VFB 2012-11-21 1.55 Crystal Structure of HIV-1 Protease Mutant N88D with novel P1'-Ligands GRL-02031
3ZPS 2013-11-06 1.55 Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors
1K1U 2002-07-10 1.55 Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
1DAZ 2000-05-03 1.55 Structural and kinetic analysis of drug resistant mutants of HIV-1 protease
5AH7 2015-02-18 1.55 Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
3TKW 2012-04-25 1.55 Crystal structure of HIV protease model precursor/Darunavir complex
4J54 2013-05-15 1.55 Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical isolate PR20 with the potent antiviral inhibitor GRL-0519A
2PQZ 2008-04-15 1.55 HIV-1 Protease in complex with a pyrrolidine-based inhibitor
4CPS 2014-12-17 1.55 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
4MC2 2014-04-02 1.56 HIV protease in complex with SA525P
2R43 2008-09-09 1.58 I50V HIV-1 protease in complex with an amino decorated pyrrolidine-based inhibitor
3QRS 2012-02-22 1.59 HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor
4U1H 2015-04-08 1.59 HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential HIV-1 escape through identical epitopes
4COC 2014-06-04 1.59 HIV-1 capsid C-terminal domain mutant (Y169L)
3EKW 2009-09-01 1.6 Crystal structure of the inhibitor Atazanavir (ATV) in complex with a multi-drug resistance HIV-1 protease variant (L10I/G48V/I54V/V64I/V82A) Refer: FLAP+ in citation.
3JVY 2009-12-08 1.6 HIV-1 Protease Mutant G86A with DARUNAVIR
3EL5 2009-09-01 1.6 Crystal structure of nelfinavir (NFV) complexed with a multidrug variant (ACT) (V82T/I84V) of HIV-1 protease
3DS1 2008-09-02 1.6 HIV-1 capsid C-terminal domain mutant (E187A) in complex with an inhibitor of particle assembly (CAI)
3BXR 2008-03-25 1.6 Crystal Structures Of Highly Constrained Substrate And Hydrolysis Products Bound To HIV-1 Protease. Implications For Catalytic Mechanism
3OU4 2011-03-30 1.6 MDR769 HIV-1 protease complexed with TF/PR hepta-peptide
3EL9 2009-09-01 1.6 Crystal structure of atazanavir (ATV) in complex with a multidrug HIV-1 protease (V82T/I84V)
3DS0 2008-09-02 1.6 HIV-1 capsid C-terminal domain mutant (N183A) in complex with an inhibitor of particle assembly (CAI)
1EXQ 2000-11-03 1.6 CRYSTAL STRUCTURE OF THE HIV-1 INTEGRASE CATALYTIC CORE DOMAIN
3HLO 2011-07-27 1.6 Crystal structure of chemically synthesized 'covalent dimer' [Gly51/D-Ala51']HIV-1 protease
2AOJ 2006-01-17 1.6 Crystal structure analysis of HIV-1 protease with a substrate analog P6-PR
3BXS 2008-03-25 1.6 Crystal Structures Of Highly Constrained Substrate And Hydrolysis Products Bound To HIV-1 Protease. Implications For Catalytic Mechanism
4G8I 2013-03-20 1.6 Crystal Structure of HLA B2705-KK10-L6M
2O4K 2006-12-12 1.6 Crystal Structure of HIV-1 Protease (Q7K) in Complex with Atazanavir
2Z4O 2008-04-22 1.6 Wild Type HIV-1 Protease with potent Antiviral inhibitor GRL-98065
4G9D 2013-03-20 1.6 Crystal Structure of HLA B2705-KK10
3OUB 2011-03-30 1.6 MDR769 HIV-1 protease complexed with NC/p1 hepta-peptide
6B3C 2018-01-03 1.6 Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,6R)-6-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide
3FSM 2010-01-05 1.6 CRYSTAL STRUCTURE OF A CHEMICALLY SYNTHESIZED 203 AMINO ACID 'COVALENT DIMER' [L-Ala51,D-Ala51'] HIV-1 PROTEASE MOLECULE
3QPJ 2012-02-15 1.61 HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor
6C8X 2018-12-05 1.61 Wild-type HIV-1 protease in complex with a phenylboronic acid (P2') analog of darunavir
3IAW 2011-04-27 1.61 Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution
6B3H 2018-01-03 1.62 Crystal Structure of HIV Protease complexed with N-(2-(2-((6R,9S)-2,2-dioxido-2-thia-1,7-diazabicyclo[4.3.1]decan-9-yl)ethyl)-3-fluorophenyl)-3,3-bis(4-fluorophenyl)propanamide
5DGW 2015-10-28 1.62 Crystal Structure of HIV-1 Protease Inhibitor GRL-105-11A Containing Substituted fused-Tetrahydropyranyl Tetrahydrofuran as P2-Ligand
3QRO 2012-02-22 1.62 HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor
6B36 2018-01-03 1.63 Crystal Structure of HIV Protease complexed with (S)-N-(3-fluoro-2-(2-(1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide
3UF3 2012-03-28 1.63 Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical isolate PR20
4IPY 2013-10-16 1.64 HIV capsid C-terminal domain
3OXX 2011-09-28 1.65 Crystal Structure of HIV-1 I50V, A71V Protease in Complex with the Protease Inhibitor Atazanavir
3CKT 2009-03-24 1.65 HIV-1 protease in complex with a dimethylallyl decorated pyrrolidine based inhibitor (orthorombic space group)
5KRT 2016-09-28 1.65 HIV-1 Integrase Catalytic Core Domain (CCD) in Complex with a Fragment-Derived Allosteric Inhibitor
2NPH 2006-12-19 1.65 Crystal structure of HIV1 protease in situ product complex
2XXM 2011-10-12 1.65 Crystal structure of the HIV-1 capsid protein C-terminal domain in complex with a camelid VHH and the CAI peptide.
4OBK 2014-11-26 1.65 Crystal structure of inactive HIV-1 protease in complex with the P1-P6 substrate variant (L449F/S451N)
2ZGA 2009-02-03 1.65 HIV-1 protease in complex with a dimethylallyl decorated pyrrolidine based inhibitor (hexagonal space group)
3KT2 2010-02-16 1.65 Crystal Structure of N88D mutant HIV-1 Protease
1ZPK 2006-04-25 1.65 Crystal structure of the complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
3O9G 2011-08-10 1.65 Crystal Structure of wild-type HIV-1 Protease in complex with af53
4CF8 2013-12-11 1.65 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
5UFZ 2018-01-10 1.65 HIV-1 Protease complexed with Inhibitor: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2S)-1-(1-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}cyclopropyl)-1-hydroxy-3-phenylpropan-2-yl]carbamate
3KDB 2010-03-02 1.66 Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10006
6P9A 2020-04-15 1.66 HIV-1 Protease multiple mutant PRS5B with Darunavir
4QJ7 2014-10-29 1.67 Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with p1-p6 substrate variant (R452S)
6BZ2 2018-02-28 1.67 Crystal structure of wild-type HIV-1 protease with a novel HIV-1 inhibitor GRL-14213A of 6-5-5-ring fused crown-like tetrahydropyranofuran as the P2-ligand, a cyclopropylaminobenzothiazole as the P2'-ligand and 3,5-difluorophenylmethyl as the P1-ligand
4OBF 2014-11-26 1.68 Crystal Structure of Nelfinavir-Resistant, Inactive HIV-1 Protease Variant (D30N/N88D) in Complex with the p1-p6 substrate variant (S451N)
4EPJ 2012-06-06 1.69 Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate p2-NC
2WHH 2009-12-01 1.69 HIV-1 protease tethered dimer Q-product complex along with nucleophilic water molecule
5XOS 2017-06-14 1.7 Crystal structure of HLA-B35 in complex with a pepetide antigen
1FFI 2001-06-01 1.7 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
5JPA 2016-08-10 1.7 Hexameric HIV-1 CA H12Y mutant
4OVL 2014-03-05 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4EQ0 2012-06-06 1.7 Crystal Structure of inactive single chain variant of HIV-1 Protease in Complex with the substrate p2-NC
4AH9 2012-12-19 1.7 Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification
3AVI 2012-02-15 1.7 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
4CPT 2014-12-17 1.7 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
3ZSR 2012-07-11 1.7 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
3AVA 2012-01-18 1.7 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
3OUA 2011-03-30 1.7 MDR769 HIV-1 protease complexed with p1/p6 hepta-peptide
3O9F 2011-08-10 1.7 Crystal Structure of wild-type HIV-1 Protease in complex with kd27
3AV9 2012-01-18 1.7 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
4CHO 2013-12-11 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4CGF 2013-12-04 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4CHY 2013-12-18 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4CJU 2014-01-22 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1HYV 2001-04-04 1.7 HIV INTEGRASE CORE DOMAIN COMPLEXED WITH TETRAPHENYL ARSONIUM
4CEZ 2013-11-27 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3ZSQ 2012-07-11 1.7 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
4CJ3 2014-01-08 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3AVG 2012-01-18 1.7 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
5KRS 2016-09-28 1.7 HIV-1 Integrase Catalytic Core Domain in Complex with an Allosteric Inhibitor, 3-(1H-pyrrol-1-yl)-2-thiophenecarboxylic acid
4E91 2012-04-25 1.7 Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BD3
4U7Q 2015-03-25 1.7 Structure of wild-type HIV protease in complex with photosensitive inhibitor PDI-6
3AVF 2012-01-18 1.7 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
2WKZ 2009-12-15 1.7 HIV-1 Protease Inhibitors Containing a Tertiary Alcohol in the Transition-State Mimic with Improved Cell-Based Antiviral Activity
3O9H 2011-08-10 1.7 Crystal Structure of wild-type HIV-1 Protease in complex with kd26
3WNE 2013-12-25 1.7 Cyclic hexapeptide PKIDNG in complex with HIV-1 integrase
5JFU 2016-09-21 1.7 HIV-1 wild Type protease with GRL-007-14A (a Adamantane P1-Ligand with bis-THF in P2 and benzylamine in P1')
1K2B 2002-07-10 1.7 Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
3AVJ 2012-01-18 1.7 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
4CIE 2014-01-08 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3OTS 2011-03-30 1.7 MDR769 HIV-1 protease complexed with MA/CA hepta-peptide
4F75 2013-05-15 1.7 Crystal Structure of active HIV-1 Protease in Complex with the N terminal product of the substrate RH-IN
3ZT2 2012-07-11 1.7 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
4CEQ 2013-11-20 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3EL1 2009-09-01 1.7 Crystal Structure of wild-type HIV protease in complex with the inhibitor, Atazanavir
1A8O 1998-10-14 1.7 HIV CAPSID C-TERMINAL DOMAIN
4CIG 2014-01-08 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1DIF 1996-03-08 1.7 HIV-1 PROTEASE IN COMPLEX WITH A DIFLUOROKETONE CONTAINING INHIBITOR A79285
4CPW 2014-12-17 1.7 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
2BBB 2005-11-15 1.7 Structure of HIV1 protease and hh1_173_3a complex.
4CEF 2013-11-20 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4CJQ 2014-01-08 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3QIN 2011-04-20 1.7 Crystal Structure of HIV-1 RNase H p15 with engineered E. coli loop and pyrimidinol carboxylic acid inhibitor
3OU3 2011-03-30 1.7 MDR769 HIV-1 protease complexed with PR/RT hepta-peptide
4CER 2013-11-20 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3NLS 2011-09-07 1.7 Crystal Structure of HIV-1 Protease in Complex with KNI-10772
1B9F 1999-07-19 1.7 MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY
3I7E 2009-09-29 1.7 Co-crystal structure of HIV-1 protease bound to a mutant resistant inhibitor UIC-98038
1B9D 1999-07-19 1.7 MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY
3I8W 2009-12-01 1.7 Crystal structure of a metallacarborane inhibitor bound to HIV protease
3OQ7 2011-04-06 1.71 Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants
3OQD 2011-04-06 1.71 Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants
4QAG 2014-06-04 1.71 Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNASE H domain of HIV-1 reverse transcriptase
3HBO 2010-05-26 1.71 Crystal structure of chemically synthesized [D-Ala51/51']HIV-1 protease
4CJT 2014-01-08 1.71 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3NDT 2011-07-20 1.72 HIV-1 Protease Saquinavir:Ritonavir 1:1 complex structure
3QRM 2012-02-22 1.73 HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor
1XL5 2005-06-07 1.73 HIV-1 Protease in complex with amidhyroxysulfone
4CGG 2013-12-04 1.75 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3ZSV 2012-07-11 1.75 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
5HRN 2016-12-14 1.75 HIV Integrase Catalytic Domain containing F185K mutation complexed with GSK0002
3BHE 2008-12-09 1.75 HIV-1 protease in complex with a three armed pyrrolidine derivative
4AHS 2012-12-19 1.75 Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification
4CK1 2014-01-22 1.75 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3OTY 2011-03-30 1.75 MDR769 HIV-1 protease complexed with RT/RH hepta-peptide
3AVK 2012-01-18 1.75 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
4I8Z 2013-07-24 1.75 Crystal structure of wild type HIV-1 protease in complex with non-peptidic inhibitor, GRL008
4CEC 2013-11-20 1.75 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3OXV 2011-09-28 1.75 Crystal Structure of HIV-1 I50V, A71 Protease in Complex with the protease inhibitor amprenavir.
4CJK 2014-01-08 1.75 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3EKV 2009-09-01 1.75 Crystal structure of the wild type HIV-1 protease with the inhibitor, Amprenavir
3ZSO 2012-07-11 1.75 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based design
4OBJ 2014-11-26 1.75 Crystal Structure of Inactive HIV-1 Protease in Complex with the p1-p6 substrate variant (S451N)
4CED 2013-11-20 1.75 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
6P9B 2020-04-15 1.75 HIV-1 Protease multiple drug resistant mutant PRS5B with Amprenavir
2UXZ 2008-05-20 1.75 Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary- Alcohol-Containing Transition-State Mimic
6DJ5 2018-10-17 1.75 HIV-1 protease with mutation L76V in complex with GRL-0519 (tris-tetrahydrofuran as P2 ligand)
1MTR 1996-08-01 1.75 HIV-1 PROTEASE COMPLEXED WITH A CYCLIC PHE-ILE-VAL PEPTIDOMIMETIC INHIBITOR
1B6L 2000-01-07 1.75 HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 4
4CEB 2013-11-20 1.75 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3ZT1 2012-07-11 1.75 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
3WNG 2013-12-25 1.75 Cyclic hexapeptide PKIDNp in complex with HIV-1 integrase
1D4L 2000-10-11 1.75 HIV-1 PROTEASE COMPLEXED WITH A MACROCYCLIC PEPTIDOMIMETIC INHIBITOR
5YRS 2018-03-07 1.76 X-ray Snapshot of HIV-1 Protease in Action: Observation of Tetrahedral Intermediate and Its SIHB with Catalytic Aspartate
4CGH 2013-12-04 1.76 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3OY4 2011-02-09 1.76 Crystal Structure of HIV-1 L76V Protease in Complex with the Protease Inhibitor Darunavir.
2UY0 2008-05-20 1.76 Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary- Alcohol-Containing Transition-State Mimic
5JL4 2017-10-04 1.76 Inhibitor resistant mutant catalytic core domain of HIV-1 Integrase
3AVC 2012-01-18 1.77 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
3KFP 2010-02-23 1.77 HIV Protease (PR) with inhibitor TL-3 bound, and DMSOs in exo site
3KFN 2010-02-23 1.77 HIV Protease (PR) with inhibitor TL-3 and fragment hit 4D9 by soaking
4CJL 2014-01-08 1.77 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4U0C 2014-11-12 1.77 Hexameric HIV-1 CA in complex with Nup153 peptide, P6 crystal form
2PWC 2008-04-15 1.78 HIV-1 protease in complex with a amino decorated pyrrolidine-based inhibitor
4OBG 2014-11-26 1.78 Crystal Structure of Nelfinavir-Resistant, Inactive HIV-1 Protease (D30N/N88D) in Complex with the p1-p6 substrate.
1FEJ 2001-06-01 1.78 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
4CK3 2014-01-22 1.79 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1EC0 2002-06-26 1.79 HIV-1 protease in complex with the inhibitor bea403
4GB2 2013-07-31 1.79 HIV-1 protease (mutant Q7K L33I L63I) in complex with a bicyclic pyrrolidine inhibitor
4DQH 2012-03-07 1.79 Crystal Structure of (R14C/E65C) HIV-1 Protease in complex with DRV
4EJK 2013-05-01 1.79 HIV Protease (PR) dimer in closed form with pepstatin in active site and fragment 1F1-N in the outside/top of flap
4Q5M 2015-04-08 1.79 D30N tethered HIV-1 protease dimer/saquinavir complex
1HXW 1998-02-04 1.8 HIV-1 PROTEASE DIMER COMPLEXED WITH A-84538
1HVR 1995-01-26 1.8 RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS
3ZCM 2012-12-05 1.8 Small molecule inhibitors of the LEDGF site of HIV integrase identified by fragment screening and structure based design.
4ICL 2013-02-06 1.8 HIV-1 reverse transcriptase with bound fragment at the incoming dNTP binding site
4CIF 2014-01-08 1.8 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4CJ4 2014-01-08 1.8 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1QBU 1997-10-15 1.8 HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
4CJS 2014-01-08 1.8 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3BGC 2008-09-02 1.8 HIV-1 protease in complex with a benzyl decorated oligoamine
4CP7 2014-12-10 1.8 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
1HVL 1994-04-30 1.8 INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE
4K4R 2013-09-18 1.8 TL-3 inhibited Trp6Ala HIV Protease with 1-bromo-2-napthoic acid bound in exosite
4CEE 2013-11-27 1.8 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
5VCK 2018-04-18 1.8 HIV Protease (PR) with TL-3 in the active site and (Z)-N-(thiazol-2-yl)-N'-tosylcarbamimidate in the exosite
3ZPU 2013-11-06 1.8 Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors
3JW2 2009-12-08 1.8 HIV-1 Protease Mutant G86S with DARUNAVIR
1QBS 1997-10-15 1.8 HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
1HVK 1994-04-30 1.8 INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE
4AHT 2012-12-19 1.8 Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification
3OU1 2011-03-30 1.8 MDR769 HIV-1 protease complexed with RH/IN hepta-peptide
3NF7 2011-04-27 1.8 Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design
2FXE 2007-02-20 1.8 X-ray crystal structure of HIV-1 protease CRM mutant complexed with atazanavir (BMS-232632)
4CEA 2013-11-20 1.8 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3NXN 2011-11-02 1.8 X-ray structure of ester chemical analogue 'covalent dimer' [Ile50,O-Ile50']HIV-1 protease complexed with KVS-1 inhibitor
4EQJ 2012-06-06 1.8 Crystal Structure of inactive single chain variant of HIV-1 Protease in Complex with the substrate RT-RH
3GGU 2009-08-11 1.8 HIV PR drug resistant patient's variant in complex with darunavir
3AO2 2011-03-16 1.8 Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase
3KT5 2010-02-16 1.8 Crystal Structure of N88S mutant HIV-1 Protease
4K4Q 2013-09-18 1.8 TL-3 inhibited Trp6Ala HIV Protease with 3-bromo-2,6-dimethoxybenzoic acid bound in flap site
6PJG 2020-07-01 1.8 HIV-1 Protease NL4-3 WT in Complex with LR3-97
3JVW 2009-12-08 1.8 HIV-1 Protease Mutant G86A with symmetric inhibitor DMP323
4A6B 2012-05-09 1.8 Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based HIV-1 Protease Inhibitors
3KF0 2010-02-23 1.8 HIV Protease with fragment 4D9 bound
1G35 2001-06-06 1.8 CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR, AHA024
1HVH 1998-12-30 1.8 NONPEPTIDE CYCLIC CYANOGUANIDINES AS HIV PROTEASE INHIBITORS
3OUD 2011-03-30 1.8 MDR769 HIV-1 protease complexed with CA/p2 hepta-peptide
2QI4 2008-04-22 1.8 Crystal structure of protease inhibitor, MIT-2-AD93 in complex with wild type HIV-1 protease
1HWR 1999-03-23 1.8 MOLECULAR RECOGNITION OF CYCLIC UREA HIV PROTEASE INHIBITORS
1EC3 2002-06-26 1.8 HIV-1 protease in complex with the inhibitor MSA367
3KDD 2010-03-02 1.8 Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10265
3GI0 2011-08-10 1.8 Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [l-ala51,d-ala51'] hiv-1 protease molecule complexed with jg-365 inhibitor
3ZSW 2012-07-11 1.8 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
3GI5 2010-03-09 1.8 Crystal structure of protease inhibitor, KB62 in complex with wild type HIV-1 protease
1W5V 2004-12-01 1.8 HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor
1FG6 2001-06-01 1.8 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
4CPR 2014-12-17 1.8 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
1W5W 2004-12-22 1.8 HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor
2R3T 2008-09-02 1.8 I50V HIV-1 protease mutant in complex with a carbamoyl decorated pyrrolidine-based inhibitor
5KAO 2016-08-31 1.8 Crystal structure of wild type HIV-1 protease in complex with GRL-10413
6AOC 2018-08-08 1.8 Crystal Structure of an N-Hydroxythienopyrimidine-2,4-dione RNase H Active Site Inhibitor with Multiple Binding Modes to HIV Reverse Transcriptase
3EKY 2009-09-01 1.8 Crystal Structure of wild-type HIV protease in complex with the inhibitor, Atazanavir
4CJR 2014-01-08 1.8 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1QBR 1997-10-15 1.8 HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
1BWB 1998-09-30 1.8 HIV-1 PROTEASE (V82F/I84V) DOUBLE MUTANT COMPLEXED WITH SD146 OF DUPONT PHARMACEUTICALS
1SP5 2005-07-19 1.8 Crystal structure of HIV-1 protease complexed with a product of autoproteolysis
4LH4 2013-12-25 1.8 Dual inhibition of HIV-1 replication by Integrase-LEDGF allosteric inhibitors is predominant at post-integration stage during virus production rather than at integration
2ZD1 2008-02-12 1.8 Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with TMC278 (Rilpivirine), A Non-nucleoside RT Inhibitor
1FGL 1997-04-01 1.8 Cyclophilin A complexed with a fragment of HIV-1 GAG protein
3KFS 2010-02-23 1.8 HIV Protease (PR) dimer with inhibitor TL-3 bound and fragment 2F4 in the outside/top of flap
4CHZ 2013-12-18 1.8 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4E92 2012-04-25 1.8 Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BM4
3HDK 2010-04-28 1.8 Crystal structure of chemically synthesized [Aib51/51']HIV-1 protease
4AHV 2012-12-19 1.8 Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification
4J5J 2013-05-15 1.8 Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Amprenavir
2XYF 2011-12-07 1.8 HIV-1 Inhibitors with a Tertiary-Alcohol-containing Transition-State Mimic and various P2 and P1 prime Substituents
1PRO 1996-08-17 1.8 HIV-1 PROTEASE DIMER COMPLEXED WITH A-98881
5HRP 2016-12-14 1.81 HIV Integrase Catalytic Domain containing F185K + A124T mutations complexed with GSK0002
1D4I 2002-06-26 1.81 HIV-1 protease in complex with the inhibitor BEA425
4EP3 2012-06-06 1.81 Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate CA-p2
1D4J 2002-06-26 1.81 HIV-1 protease in complex with the inhibitor MSL370
1EBW 2002-06-26 1.81 HIV-1 protease in complex with the inhibitor BEA322
1D4H 2002-06-26 1.81 HIV-1 Protease in complex with the inhibitor BEA435
2R38 2008-09-02 1.81 I84V HIV-1 protease mutant in complex with a carbamoyl decorated pyrrolidine-based inhibitor
6OOT 2019-08-21 1.82 HIV-1 Protease NL4-3 L89V, L90M Mutant in complex with darunavir
3BC4 2008-09-02 1.82 I84V HIV-1 protease in complex with a pyrrolidine diester
4CPU 2014-12-17 1.82 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
4OJR 2014-06-11 1.82 Crystal Structure of the HIV-1 Integrase catalytic domain with GSK1264
1IIQ 2002-04-12 1.83 CRYSTAL STRUCTURE OF HIV-1 PROTEASE COMPLEXED WITH A HYDROXYETHYLAMINE PEPTIDOMIMETIC INHIBITOR
4QJ9 2014-10-29 1.83 Crystal structure of inactive HIV-1 protease in complex with p1-p6 substrate variant (R452S)
5TC2 2018-04-04 1.84 C-terminal domain of HIV-1 integrase, crystal structure
3GI6 2010-03-09 1.84 Crystal structure of protease inhibitor, AD78 in complex with wild type HIV-1 protease
4CF0 2013-11-20 1.85 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
6PJH 2020-07-01 1.85 HIV-1 Protease NL4-3 WT in Complex with LR3-28
2QI7 2008-04-22 1.85 Crystal structure of protease inhibitor, MIT-2-AD86 in complex with wild type HIV-1 protease
3DLK 2008-10-07 1.85 Crystal Structure of an engineered form of the HIV-1 Reverse Transcriptase, RT69A
3MXE 2010-11-10 1.85 Crystal structure of HIV-1 protease inhibitor, KC32 complexed with wild-type protease
6D0D 2019-05-01 1.85 X-ray crystal structure of wild type HIV-1 protease in complex with GRL-087-13
4CES 2013-11-20 1.85 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4COP 2014-06-04 1.85 HIV-1 capsid C-terminal domain mutant (Y169S)
4Q1W 2015-02-18 1.85 Mutations Outside the Active Site of HIV-1 Protease Alter Enzyme Structure and Dynamic Ensemble of the Active Site to Confer Drug Resistance
2QI5 2008-04-22 1.85 Crystal structure of protease inhibitor, MIT-2-KC08 in complex with wild type HIV-1 protease
2FNS 2006-09-05 1.85 Crystal structure of wild-type inactive (D25N) HIV-1 protease complexed with wild-type HIV-1 NC-p1 substrate.
2QHZ 2008-04-22 1.85 Crystal structure of protease inhibitor, MIT-1-AC87 in complex with wild type HIV-1 protease
1B6K 2000-01-07 1.85 HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 5
1FG8 2001-06-01 1.85 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
2QHY 2008-04-22 1.85 Crystal Structure of protease inhibitor, MIT-1-AC86 in complex with wild type HIV-1 protease
4OBH 2014-11-26 1.85 Crystal Structure of Inactive HIV-1 Protease in Complex with the p1-p6 substrate variant (L449F)
3GI4 2010-03-09 1.85 Crystal structure of protease inhibitor, KB60 in complex with wild type HIV-1 protease
1D4K 2000-10-11 1.85 HIV-1 PROTEASE COMPLEXED WITH A MACROCYCLIC PEPTIDOMIMETIC INHIBITOR
1B6J 2000-01-07 1.85 HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 1
3NU9 2010-08-25 1.85 Crystal Structure of HIV-1 Protease Mutant I84V with Antiviral Drug Amprenavir
1FF0 2001-06-01 1.85 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES.
1Z1R 2005-03-22 1.85 HIV-1 protease complexed with Macrocyclic peptidomimetic inhibitor 2
4CPX 2014-12-17 1.85 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
3AVB 2012-01-18 1.85 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
2PYN 2008-02-26 1.85 HIV-1 PR mutant in complex with nelfinavir
4KFB 2013-05-15 1.85 HIV-1 reverse transcriptase with bound fragment at NNRTI adjacent site
4CK2 2014-01-22 1.85 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4F76 2013-05-15 1.85 Crystal Structure of the active HIV-1 Protease in Complex with the products of p1-p6 substrate
1Z1H 2005-03-22 1.85 HIV-1 protease complexed with macrocyclic peptidomimetic inhibitor 3
1B6M 2000-01-07 1.85 HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 6
2QI6 2008-04-22 1.85 Crystal structure of protease inhibitor, MIT-2-KB98 in complex with wild type HIV-1 protease
6OXU 2019-08-21 1.86 HIV-1 Protease NL4-3 WT in Complex with LR-99
5HRS 2016-12-14 1.86 HIV Integrase Catalytic Domain containing F185K + A124N + T125A mutations complexed with GSK0002
6OXT 2019-08-21 1.86 HIV-1 Protease NL4-3 WT in Complex with LR-84
4ID1 2013-05-01 1.87 HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor
3AVM 2012-01-18 1.88 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
3AVL 2012-01-18 1.88 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
1DW6 2000-07-26 1.88 Structural and kinetic analysis of drug resistant mutants of HIV-1 protease
5HRR 2016-12-14 1.88 HIV Integrase Catalytic Domain containing F185K + A124N + T125S mutations complexed with GSK0002
3AVH 2012-01-18 1.88 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
6OXQ 2019-08-21 1.89 HIV-1 Protease NL4-3 WT in Complex with UMass8
6PJD 2020-07-01 1.89 HIV-1 Protease NL4-3 WT in Complex with LR2-32
2XV6 2011-10-12 1.89 Crystal structure of the HIV-1 capsid protein C-terminal domain (146- 220) in complex with a camelid VHH.
4F73 2013-05-15 1.9 Crystal Structure of active HIV-1 Protease in Complex with the N terminal product of CA-p2 cleavage site
4E1M 2012-04-25 1.9 Crystal Structure of HIV-1 Integrase with a non-catayltic site inhibitor
2WL0 2009-12-15 1.9 HIV-1 Protease Inhibitors Containing a Tertiary Alcohol in the Transition-State Mimic with Improved Cell-Based Antiviral Activity
4CJE 2014-01-08 1.9 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1MEU 1998-04-15 1.9 HIV-1 MUTANT (V82F, I84V) PROTEASE COMPLEXED WITH DMP323
1HPV 1995-03-31 1.9 CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH VX-478, A POTENT AND ORALLY BIOAVAILABLE INHIBITOR OF THE ENZYME
4Q1X 2015-02-18 1.9 Mutations Outside the Active Site of HIV-1 Protease Alter Enzyme Structure and Dynamic Ensemble of the Active Site to Confer Drug Resistance
4G9F 2013-03-20 1.9 Crystal Structure of C12C TCR-HLAB2705-KK10-L6M
1MET 1998-04-15 1.9 HIV-1 MUTANT (V82F) PROTEASE COMPLEXED WITH DMP323
1FGC 2001-06-01 1.9 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
3MGE 2010-07-21 1.9 X-ray Structure of Hexameric HIV-1 CA
6PJI 2020-07-01 1.9 HIV-1 Protease NL4-3 WT in Complex with LR3-43
2ZYE 2009-03-24 1.9 Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by Neutron Crystallography
2PWM 2007-09-25 1.9 Crystal Structure of HIV-1 CA146 A92E real cell
4CFC 2013-11-27 1.9 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
2PYM 2008-02-26 1.9 HIV-1 PR mutant in complex with nelfinavir
1SGU 2004-10-05 1.9 Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease
2BPV 1999-02-23 1.9 HIV-1 protease-inhibitor complex
1MER 1998-04-15 1.9 HIV-1 MUTANT (I84V) PROTEASE COMPLEXED WITH DMP450
4DGA 2012-02-08 1.9 TRIMCyp cyclophilin domain from Macaca mulatta: HIV-1 CA(O-loop) complex
6OOS 2019-08-21 1.9 HIV-1 Protease NL4-3 L90M Mutant in complex with darunavir
3H47 2009-06-23 1.9 X-ray Structure of Hexameric HIV-1 CA
3NWX 2011-11-02 1.9 X-ray structure of ester chemical analogue [O-Ile50,O-Ile50']HIV-1 protease complexed with KVS-1 inhibitor
1G6L 2000-11-15 1.9 1.9A CRYSTAL STRUCTURE OF TETHERED HIV-1 PROTEASE
4QGI 2014-07-16 1.9 X-ray crystal structure of HIV-1 protease variant G48T/L89M in complex with Saquinavir
3BGB 2008-09-02 1.9 HIV-1 protease in complex with a isobutyl decorated oligoamine
1MES 1998-04-15 1.9 HIV-1 MUTANT (I84V) PROTEASE COMPLEXED WITH DMP323
4EP2 2012-06-06 1.9 Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate RT-RH
1BWA 1998-10-30 1.9 HIV-1 PROTEASE (V82F/I84V) DOUBLE MUTANT COMPLEXED WITH XV638 OF DUPONT PHARMACEUTICALS
2GON 2006-09-26 1.9 Xray Structure of Gag133-278
1FFF 2001-06-01 1.9 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE : HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES.
4AHR 2012-12-19 1.9 Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification
1MT7 2003-01-07 1.9 Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
5TSX 2017-11-08 1.9 HIV-1 CA hexamer with NUP153 peptide - P1 crystal form
3NF6 2011-04-27 1.9 Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design
6BJ3 2018-07-25 1.9 TCR55 in complex with HIV(Pol448-456)/HLA-B35
4OBD 2014-11-26 1.9 Crystal Structure of Nelfinavir-Resistant, Inactive HIV-1 Protease (D30N/N88D) in Complex with the p1-p6 substrate variant (L449F/S451N)
1W5Y 2004-10-07 1.9 HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor
3NF8 2011-04-27 1.9 Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design
2AID 1997-10-15 1.9 STRUCTURE OF A NON-PEPTIDE INHIBITOR COMPLEXED WITH HIV-1 PROTEASE: DEVELOPING A CYCLE OF STRUCTURE-BASED DRUG DESIGN
2BPY 1999-02-23 1.9 HIV-1 protease-inhibitor complex
4DQF 2012-03-07 1.9 Crystal Structure of (G16A/L38A) HIV-1 Protease in Complex with DRV
6C0O 2018-08-01 1.9 Crystal structure of HIV-1 K103N mutant reverse transcriptase in complex with non-nucleoside inhibitor 25a
5HGN 2016-08-10 1.9 Hexameric HIV-1 CA, apo form
1W5X 2004-12-22 1.9 HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor
6ES8 2018-08-15 1.9 HIV capsid hexamer with IP6 ligand
4CHP 2013-12-11 1.9 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4AHU 2012-12-19 1.9 Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification
3R4B 2011-09-21 1.9 Crystal Structure of Wild-type HIV-1 Protease in Complex With TMC310911
4CEO 2013-11-20 1.9 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1M9D 2003-05-27 1.9 X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) O-type chimera Complex.
4NYF 2014-06-25 1.9 HIV integrase in complex with inhibitor
4CJF 2014-01-08 1.9 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
2R3W 2008-09-02 1.92 I84V HIV-1 protease in complex with a amino decorated pyrrolidine-based inhibitor
6PJE 2020-07-01 1.92 HIV-1 Protease NL4-3 WT in Complex with LR2-43
6C0J 2018-08-01 1.92 Crystal structure of HIV-1 reverse transcriptase in complex with non-nucleoside inhibitor K-5a2
4U1I 2015-04-08 1.92 HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential HIV-1 escape through identical epitopes
1ZJ7 2006-05-09 1.93 Crystal structure of a complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[S-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
6PJM 2020-07-01 1.93 HIV-1 Protease NL4-3 WT in Complex with LR2-35
4Y1D 2015-05-13 1.93 Cyclic hexapeptide cyc[NdPopPKID] in complex with HIV-1 integrase core domain
6C8Y 2018-12-05 1.94 D30N HIV-1 protease in complex with a phenylboronic acid (P2') analog of darunavir
4DQC 2012-03-07 1.94 Crystal Structure of (G16C/L38C) HIV-1 Protease in Complex with DRV
6PJF 2020-07-01 1.94 HIV-1 Protease NL4-3 WT in Complex with LR2-44
6CGF 2018-08-01 1.94 Crystal structure of HIV-1 Y188L mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2
4XRQ 2015-07-15 1.95 Disulfide stabilized HIV-1 CA hexamer 4mut (S41A, Q67H, V165I, L172I) in complex with PF-3450074
3NFA 2011-04-27 1.95 Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design
6C0L 2018-08-01 1.95 Crystal structure of HIV-1 E138K mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2
1BIZ 1998-08-19 1.95 HIV-1 INTEGRASE CORE DOMAIN
1BIS 1998-08-19 1.95 HIV-1 INTEGRASE CORE DOMAIN
4CJV 2014-01-22 1.95 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
2X2D 2010-03-23 1.95 acetyl-CypA:HIV-1 N-term capsid domain complex
3OXW 2011-09-28 1.95 Crystal Structure of HIV-1 I50V, A71V Protease in Complex with the Protease Inhibitor Darunavir
4LQW 2013-08-14 1.95 Crystal structure of HIV-1 capsid N-terminal domain in complex with NUP358 cyclophilin
3ZT0 2012-07-11 1.95 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
4HLA 2013-07-24 1.95 Crystal structure of wild type HIV-1 protease in complex with darunavir
4ID5 2013-02-06 1.95 HIV-1 reverse transcriptase with bound fragment at the RNase H primer grip site
4CF2 2013-11-20 1.95 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
2QI3 2008-04-22 1.95 Crystal structure of protease inhibitor, MIT-2-AD94 in complex with wild type HIV-1 protease
6PJO 2020-07-01 1.95 HIV-1 Protease NL4-3 WT in Complex with LR2-42
4KO0 2013-08-14 1.95 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH an anilinylpyrimidine derivative (JLJ-135)
3NF9 2011-04-27 1.95 Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design
5HGP 2016-10-19 1.95 Hexameric HIV-1 CA in complex with hexacarboxybenzene
3LPU 2010-05-12 1.95 HIV integrase
4CJW 2014-01-22 1.95 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4CFB 2013-11-27 1.95 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4CJ5 2014-01-08 1.95 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4IG3 2013-02-06 1.95 HIV-1 reverse transcriptase with bound fragment near Knuckles site
3ZT3 2012-07-11 1.95 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
1G2K 2001-06-01 1.95 HIV-1 PROTEASE WITH CYCLIC SULFAMIDE INHIBITOR, AHA047
3MXD 2010-11-10 1.95 Crystal structure of HIV-1 protease inhibitor KC53 in complex with wild-type protease
4CF1 2013-12-18 1.95 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4CHQ 2013-12-11 1.95 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
6D0E 2019-05-01 1.95 X-ray crystal structure of wild type HIV-1 protease in complex with GRL-084-13
3ZSX 2012-07-11 1.95 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
6OXX 2019-08-21 1.96 HIV-1 Protease NL4-3 WT in Complex with LR2-18
6C0K 2018-08-01 1.96 Crystal structure of HIV-1 K103N mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2
4I8W 2013-07-24 1.96 Crystal structure of wild type HIV-1 protease in complex with non-peptidic inhibitor, GRL007
6DUF 2018-08-01 1.96 Crystal structure of HIV-1 reverse transcriptase V106A/F227L mutant in complex with non-nucleoside inhibitor 25a
6OXY 2019-08-21 1.96 HIV-1 Protease NL4-3 WT in Complex with LR2-19
6OXZ 2019-08-21 1.96 HIV-1 Protease NL4-3 WT in Complex with LR2-20
6PJC 2020-07-01 1.97 HIV-1 Protease NL4-3 WT in Complex with LR4-41
3EKT 2009-09-01 1.97 Crystal Structure of the inhibitor Darunavir (DRV) in complex with a multi-drug resistant HIV-1 protease variant (L10F/G48V/I54V/V64I/V82A) (Refer: FLAP+ in citation.)
1D4Y 1999-10-13 1.97 HIV-1 PROTEASE TRIPLE MUTANT/TIPRANAVIR COMPLEX
3EKX 2009-09-01 1.97 Crystal structure of the wild-type HIV-1 protease with the inhibitor, Nelfinavir
6OXP 2019-08-21 1.97 HIV-1 Protease NL4-3 WT in Complex with UMass3
3LRY 2010-03-09 1.98 Crystal structure of synthetic HIV-1 capsid C-terminal domain (CCA)
6PJB 2020-07-01 1.98 HIV-1 Protease NL4-3 WT in Complex with Lopinavir
6PJN 2020-07-01 1.98 HIV-1 Protease NL4-3 WT in Complex with LR2-41
6OXW 2019-08-21 1.98 HIV-1 Protease NL4-3 WT in Complex with LR-100
6BHS 2018-08-01 1.98 HIV-1 CA hexamer in complex with IP6, hexagonal crystal form
1ZSF 2006-04-25 1.98 Crystal Structure of Complex of a Hydroxyethylamine Inhibitor with HIV-1 Protease at 2.0A Resolution
6OY2 2019-08-21 1.99 HIV-1 Protease NL4-3 WT in Complex with LR2-25
6OXV 2019-08-21 1.99 HIV-1 Protease NL4-3 WT in Complex with LR-85
6PJL 2020-07-01 1.99 HIV-1 Protease NL4-3 WT in Complex with LR3-95
6OXS 2019-08-21 1.99 HIV-1 Protease NL4-3 WT in Complex with LR-76
4QNB 2014-12-31 2.0 Disulfide stabilized HIV-1 CA hexamer in complex with PHENYL-L-PHENYLALANINAMIDE inhibitor
1EC2 2002-06-26 2.0 HIV-1 protease in complex with the inhibitor BEA428
1ODX 1997-04-01 2.0 HIV-1 Proteinase mutant A71T, V82A
3OUC 2011-03-30 2.0 MDR769 HIV-1 protease complexed with p2/NC hepta-peptide
1MRW 2003-11-04 2.0 Structure of HIV protease (Mutant Q7K L33I L63I) complexed with KNI-577
1KJF 2002-03-06 2.0 SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES
1NPA 2004-01-27 2.0 crystal structure of HIV-1 protease-hup
3ZSZ 2012-07-11 2.0 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
4FE6 2012-07-18 2.0 Crystal Structure of HIV-1 Protease in Complex with an enamino-oxindole inhibitor
2AQU 2006-08-29 2.0 Structure of HIV-1 protease bound to atazanavir
2QI1 2008-04-22 2.0 Crystal structure of protease inhibitor, MIT-1-KK81 in complex with wild type HIV-1 protease
1A94 1999-01-13 2.0 STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES
2FGU 2006-11-07 2.0 X-ray crystal structure of HIV-1 Protease T80S variant in complex with the inhibitor saquinavir used to explore the role of invariant Thr80 in HIV-1 protease structure, function, and viral infectivity.
2AZ8 2006-02-28 2.0 HIV-1 Protease NL4-3 in complex with inhibitor, TL-3
1BL3 1998-09-30 2.0 CATALYTIC DOMAIN OF HIV-1 INTEGRASE
4CJP 2014-01-08 2.0 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1BV9 1998-09-30 2.0 HIV-1 PROTEASE (I84V) COMPLEXED WITH XV638 OF DUPONT PHARMACEUTICALS
2O4N 2006-12-12 2.0 Crystal Structure of HIV-1 Protease (TRM Mutant) in Complex with Tipranavir
7UPJ 1997-04-21 2.0 HIV-1 PROTEASE/U101935 COMPLEX
6OXO 2019-08-21 2.0 HIV-1 Protease NL4-3 WT in Complex with LR2-91
1A8K 1999-01-13 2.0 CRYSTALLOGRAPHIC ANALYSIS OF HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEASE WITH AN ANALOG OF THE CONSERVED CA-P2 SUBSTRATE: INTERACTIONS WITH FREQUENTLY OCCURRING GLUTAMIC ACID RESIDUE AT P2' POSITION OF SUBSTRATES
3LPT 2010-05-12 2.0 HIV integrase
4E1N 2012-04-25 2.0 Crystal Structure of HIV-1 Integrase with a non-catayltic site inhibitor
2NXD 2007-09-18 2.0 Structure of HIV-1 protease D25N complexed with rt-rh analogue peptide GLY-ALA-ASP-ILE-PHE*TYR-LEU-ASP-GLY-ALA
1MSM 2003-11-04 2.0 The HIV protease (mutant Q7K L33I L63I) complexed with KNI-764 (an inhibitor)
4CGD 2013-12-04 2.0 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
6C0N 2018-08-01 2.0 Crystal structure of HIV-1 reverse transcriptase in complex with non-nucleoside inhibitor 25a
4JMU 2013-10-30 2.0 Crystal structure of HIV matrix residues 1-111 in complex with inhibitor
6DUH 2018-08-01 2.0 Crystal structure of HIV-1 reverse transcriptase Y181I mutant in complex with non-nucleoside inhibitor 25a
1AXA 1998-04-15 2.0 ACTIVE-SITE MOBILITY IN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AS DEMONSTRATED BY CRYSTAL STRUCTURE OF A28S MUTANT
5T6Z 2017-03-01 2.0 KIR3DL1 in complex with HLA-B*57:01-TW10
5HGO 2016-08-10 2.0 Hexameric HIV-1 CA R18G mutant
3EL0 2009-09-01 2.0 Crystal structure of the inhibitor Nelfinavir (NFV) in complex with a multi-drug resistant HIV-1 protease variant (L10I/G48V/I54V/V64I/V82A) (Refer: FLAP+ in citation)
1HTG 1994-07-31 2.0 X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE
6V2F 2020-07-01 2.0 Crystal structure of the HIV capsid hexamer bound to the small molecule long-acting inhibitor, GS-6207
2XYE 2011-12-07 2.0 HIV-1 Inhibitors with a Tertiary-Alcohol-containing Transition-State Mimic and various P2 and P1 prime Substituents
1MSN 2003-11-04 2.0 The HIV protease (mutant Q7K L33I L63I V82F I84V) complexed with KNI-764 (an inhibitor)
1ODY 1999-02-16 2.0 HIV-1 PROTEASE COMPLEXED WITH AN INHIBITOR LP-130
1F7A 2001-06-27 2.0 HOW DOES A SYMMETRIC DIMER RECOGNIZE AN ASYMMETRIC SUBSTRATE? A SUBSTRATE COMPLEX OF HIV-1 PROTEASE.
6CPN 2018-06-06 2.0 Crystal structure of DR11 presenting the RQ13 peptide
1AJX 1997-09-17 2.0 HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC UREA INHIBITOR AHA001
1MRX 2003-11-04 2.0 Structure of HIV protease (Mutant Q7K L33I L63I V82F I84V ) complexed with KNI-577
1KJG 2002-03-06 2.0 SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES
1KJ7 2002-03-06 2.0 SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES
1RL8 2005-04-19 2.0 Crystal structure of the complex of resistant strain of hiv-1 protease(v82a mutant) with ritonavir
4CHN 2013-12-11 2.0 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
6PJK 2020-07-01 2.0 HIV-1 Protease NL4-3 WT in Complex with LR3-29
1B6P 2000-01-07 2.0 HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 7
1HVJ 1994-04-30 2.0 INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE
6OY0 2019-08-21 2.0 HIV-1 Protease NL4-3 WT in Complex with LR2-21
1A30 1998-04-29 2.0 HIV-1 PROTEASE COMPLEXED WITH A TRIPEPTIDE INHIBITOR
1MT9 2003-01-07 2.0 Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
6B2K 2018-09-26 2.0 E45A/R132T mutant of HIV-1 capsid protein
5HVP 1991-10-15 2.0 CRYSTALLOGRAPHIC ANALYSIS OF A COMPLEX BETWEEN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AND ACETYL-PEPSTATIN AT 2.0-ANGSTROMS RESOLUTION
5V5L 2017-06-14 2.0 Crystal structure of HLA-B*5801 complex with HIV-1 gag derived peptide TW10
6J1V 2019-09-25 2.0 The structure of HLA-A*3003/RT313
1KJH 2002-03-06 2.0 SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES
2Q3K 2007-08-21 2.0 Crystal Structure of Lysine Sulfonamide Inhibitor Reveals the Displacement of the Conserved Flap Water Molecule in HIV-1 Protease
6H09 2018-08-15 2.0 HIV capsid hexamer with IP6 ligand
1TSQ 2005-03-29 2.0 CRYSTAL STRUCTURE OF AP2V SUBSTRATE VARIANT OF NC-P1 DECAMER PEPTIDE IN COMPLEX WITH V82A/D25N HIV-1 PROTEASE MUTANT
1AJV 1997-08-20 2.0 HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006
2NXL 2007-09-18 2.0 Structure of HIV-1 protease D25N complexed with the rt-rh analogue peptide GLY-ALA-GLU-VAL-PHE*TYR-VAL-ASP-GLY-ALA
1HPX 1996-03-08 2.0 HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR KNI-272
3EL4 2009-09-01 2.0 Crystal structure of inhibitor saquinavir (SQV) complexed with the multidrug HIV-1 protease variant L63P/V82T/I84V
1K6V 2002-02-06 2.0 LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE
3TLH 1998-12-09 2.0 STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITHAN EFFICIENT INHIBITOR OF FIV PR
6OY1 2019-08-21 2.0 HIV-1 Protease NL4-3 WT in Complex with LR2-26
1ZBG 2006-04-18 2.0 Crystal structure of a complex of mutant hiv-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
1BV7 1998-09-30 2.0 COUNTERACTING HIV-1 PROTEASE DRUG RESISTANCE: STRUCTURAL ANALYSIS OF MUTANT PROTEASES COMPLEXED WITH XV638 AND SD146, CYCLIC UREA AMIDES WITH BROAD SPECIFICITIES
5VJ3 2018-04-18 2.0 HIV Protease (PR) in open form with Mg2+ in active site and HIVE-9 in eye site
3DOX 2008-09-09 2.0 X-ray structure of HIV-1 protease in situ product complex
1HSG 1996-04-03 2.0 CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES
1NPV 2003-02-04 2.0 Crystal structure of HIV-1 protease complexed with LDC271
5VEA 2018-04-25 2.0 HIV Protease (PR) with TL-3 in active site and 4-methylbenzene-1,2-diamine in exosite
1DMP 1997-11-12 2.0 STRUCTURE OF HIV-1 PROTEASE COMPLEX
1NPW 2003-02-04 2.0 Crystal structure of HIV protease complexed with LGZ479
4QJ8 2014-10-29 2.0 Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with p1-p6 substrate variant (P453L)
1HIV 1993-10-31 2.0 CRYSTAL STRUCTURE OF A COMPLEX OF HIV-1 PROTEASE WITH A DIHYDROETHYLENE-CONTAINING INHIBITOR: COMPARISONS WITH MOLECULAR MODELING
1EBZ 2002-06-26 2.01 HIV-1 protease in complex with the inhibitor BEA388
4XRO 2015-07-15 2.01 Disulfide stabilized HIV-1 CA hexamer 4mut (S41A, Q67H, V165I, L172I)
2AZC 2006-02-28 2.01 HIV-1 Protease NL4-3 6X mutant
6EX9 2018-06-06 2.01 Crystal Structure of HIV-1 Integrase Catalytic Core Domain with Inhibitor Peptide
3DPH 2008-09-02 2.01 HIV-1 capsid C-terminal domain mutant (L211S)
1ZPA 2005-05-31 2.02 HIV Protease with Scripps AB-3 Inhibitor
2B4J 2005-10-25 2.02 Structural basis for the recognition between HIV-1 integrase and LEDGF/p75
1B92 1999-07-19 2.02 MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY
2AZB 2006-02-28 2.03 HIV-1 Protease NL4-3 3X mutant in complex with inhibitor, TL-3
5HGM 2016-08-10 2.04 Hexameric HIV-1 CA in complex with dATP
3K2P 2010-02-09 2.04 HIV-1 Reverse Transcriptase Isolated RnaseH Domain with the Inhibitor beta-thujaplicinol Bound at the Active Site
6OXR 2019-08-21 2.04 HIV-1 Protease NL4-3 WT in Complex with LR-82
4U0E 2014-11-12 2.04 Hexameric HIV-1 CA in complex with PF3450074
4CFA 2013-11-27 2.05 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4O0J 2014-07-02 2.05 HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[4-(4-chlorophenyl)-6-(3,4-dimethylphenyl)-2,5-dimethylpyridin-3-yl]ethanoic acid
4IFV 2013-02-06 2.05 Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-Ray Crystallographic Fragment Screening
6C0P 2018-08-01 2.05 Crystal structure of HIV-1 E138K mutant reverse transcriptase in complex with non-nucleoside inhibitor 25a
3U7S 2012-01-18 2.05 HIV PR drug resistant patient's variant in complex with darunavir
5TEO 2017-09-27 2.05 Dimer of HIV-1 Gag CTD-SP1 fragment
6C0R 2018-08-01 2.05 Crystal structure of HIV-1 K103N/Y181C mutant reverse transcriptase in complex with non-nucleoside inhibitor 25a
4U0A 2014-11-12 2.05 Hexameric HIV-1 CA in complex with CPSF6 peptide, P6 crystal form
1CPI 1996-03-08 2.05 REGIOSELECTIVE STRUCTURAL AND FUNCTIONAL MIMICRY OF PEPTIDES. DESIGN OF HYDROLYTICALLY STABLE CYCLIC PEPTIDOMIMETIC INHIBITORS OF HIV-1 PROTEASE
6OMT 2019-08-21 2.05 HIV-1 capsid hexamer R18D mutant
1ZSR 2006-04-25 2.06 Crystal structure of wild type HIV-1 protease (BRU isolate) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[S-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
1EBK 2000-07-26 2.06 Structural and kinetic analysis of drug resistant mutants of HIV-1 protease
3PSU 2011-12-07 2.07 HIV-1 protease in complex with an isobutyl decorated oligoamine (symmetric binding mode)
4CGI 2013-12-04 2.07 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4JLH 2013-05-01 2.09 HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor
3QIP 2011-04-20 2.09 Structure of HIV-1 reverse transcriptase in complex with an RNase H inhibitor and nevirapine
5W4O 2018-06-20 2.09 Structure of the R18A mutant of the HIV-1 capsid protein
1T7K 2004-10-05 2.1 Crystal Structure of HIV Protease complexed with Arylsulfonamide azacyclic urea
2QI0 2008-04-22 2.1 Crystal structure of protease inhibitor, MIT-1-KK80 in complex with wild type HIV-1 protease
1QS4 1999-11-17 2.1 Core domain of HIV-1 integrase complexed with Mg++ and 1-(5-chloroindol-3-yl)-3-hydroxy-3-(2H-tetrazol-5-yl)-propenone
6LMQ 2020-09-23 2.1 Crystal structure of HIV-1 integrase catalytic core domain in complex with 2-(tert-butoxy)-2-[3-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)-6-methanesulfonamido-2,3',4',5-tetramethyl-[1,1'-biphenyl]-4-yl]acetic acid
2X4U 2010-03-02 2.1 Crystal structure of MHC CLass I HLA-A2.1 bound to HIV-1 Peptide RT468-476
4CE9 2013-11-20 2.1 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4IDK 2013-02-06 2.1 HIV-1 reverse transcriptase with bound fragment at the 428 site
4CF9 2013-11-27 2.1 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1EC1 2002-06-26 2.1 HIV-1 protease in complex with the inhibitor BEA409
5CYM 2015-12-30 2.1 HIV-1 reverse transcriptase complexed with 4-iodopyrazole
5T70 2017-03-01 2.1 KIR3DL1 in complex with HLA-B*57:01 presenting TSNLQEQIGW
1ODW 1997-04-01 2.1 Native HIV-1 Proteinase
4FAF 2012-08-29 2.1 Substrate CA/p2 in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant
3BGR 2008-02-12 2.1 Crystal structure of K103N/Y181C mutant HIV-1 reverse transcriptase (RT) in complex with TMC278 (Rilpivirine), a non-nucleoside RT inhibitor
3AVN 2012-01-18 2.1 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
1QBT 1997-10-15 2.1 HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
1TSU 2005-03-29 2.1 CRYSTAL STRUCTURE OF DECAMER NCP1 SUBSTRATE PEPTIDE IN COMPLEX WITH WILD-TYPE D25N HIV-1 PROTEASE VARIANT
4PHV 1993-10-31 2.1 X-RAY CRYSTAL STRUCTURE OF THE HIV PROTEASE COMPLEX WITH L-700,417, AN INHIBITOR WITH PSEUDO C2 SYMMETRY
6OPW 2019-09-04 2.1 HIV-1 Protease NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, A71V, V82F, I84V Mutant in complex with darunavir
3EM6 2009-09-01 2.1 Crystal structure of I50L/A71V mutant of hiv-1 protease in complex with inhibitor darunavir
3T3C 2012-06-20 2.1 Structure of HIV PR resistant patient derived mutant (comprising 22 mutations) in complex with DRV
3EM4 2009-09-01 2.1 Crystal structure of atazanavir (ATV) in complex with I50L/A71V drug-resistant HIV-1 protease
1LV1 2002-06-19 2.1 Crystal Structure Analysis of the non-active site mutant of tethered HIV-1 protease to 2.1A resolution
4IFY 2013-02-06 2.1 HIV-1 reverse transcriptase with bound fragment at the Knuckles site
2YKN 2011-08-17 2.12 Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with a Difluoromethylbenzoxazole (DFMB) Pyrimidine Thioether derivative, a non-nucleoside RT inhibitor (NNRTI)
2YNG 2013-01-09 2.12 HIV-1 Reverse Transcriptase in complex with inhibitor GSK560
6OPY 2019-09-04 2.13 HIV-1 Protease NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, A71V, L76V, V82F, I84V Mutant in complex with darunavir
6OOU 2019-08-21 2.13 Crystal structure of HIV-1 Protease NL4-3 L89V Mutant in complex with darunavir
3EKP 2009-09-01 2.15 Crystal Structure of the inhibitor Amprenavir (APV) in complex with a multi-drug resistant HIV-1 protease variant (L10I/G48V/I54V/V64I/V82A)Refer: FLAP+ in citation
6JCF 2019-07-17 2.15 Cryogenic structure of HIV-1 Integrase catalytic core domain by synchrotron
1ZTZ 2005-11-01 2.15 Crystal structure of HIV protease- metallacarborane complex
4CFD 2013-11-27 2.15 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1IZI 2002-12-23 2.15 Inhibitor of HIV protease with unusual binding mode potently inhibiting multi-resistant protease mutants
3LZV 2010-08-11 2.15 Structure of Nelfinavir-resistant HIV-1 protease (D30N/N88D) in complex with Darunavir.
1MT8 2003-01-07 2.15 Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
4DG1 2012-06-20 2.15 Crystal structure of HIV-1 reverse transcriptase (RT) with polymorphism mutation K172A and K173A
5CYQ 2015-12-30 2.15 HIV-1 reverse transcriptase complexed with 4-bromopyrazole
4CGJ 2013-12-04 2.15 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4GVM 2013-05-01 2.16 HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor
5W4P 2018-06-20 2.19 Structure of the E28A mutant of the HIV-1 capsid protein
4LH5 2013-12-25 2.19 Dual inhibition of HIV-1 replication by Integrase-LEDGF allosteric inhibitors is predominant at post-integration stage during virus production rather than at integration
3ZSY 2012-07-11 2.2 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
3DLG 2008-08-12 2.2 Crystal structure of hiv-1 reverse transcriptase in complex with GW564511.
1BHL 1998-10-14 2.2 CACODYLATED CATALYTIC DOMAIN OF HIV-1 INTEGRASE
1HIH 1995-07-10 2.2 COMPARATIVE ANALYSIS OF THE X-RAY STRUCTURES OF HIV-1 AND HIV-2 PROTEASES IN COMPLEX WITH CGP 53820, A NOVEL PSEUDOSYMMETRIC INHIBITOR
3ZT4 2012-07-18 2.2 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
1K2C 2002-07-10 2.2 Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
6OPZ 2019-09-04 2.2 HIV-1 Protease NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, I54L, A71V, L76V, V82F, I84V Mutant in complex with darunavir
2QAK 2008-07-01 2.2 HIV-1 PR mutant in complex with nelfinavir
4F74 2013-05-15 2.2 Crystal Structure of active HIV-1 Protease in Complex with the N terminal product of the substrate MA-CA.
3UHL 2012-03-28 2.2 Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with p2-NC substrate analog
1HTF 1994-07-31 2.2 X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE
1Z8C 2006-03-21 2.2 Crystal structure of the complex of mutant HIV-1 protease (l63P, A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
1VRT 1996-04-03 2.2 HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
1N49 2003-01-07 2.2 Viability of a Drug-Resistant HIV-1 Protease Variant: Structural Insights for Better Anti-Viral Therapy
1YTH 1997-03-12 2.2 SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT
1RTH 1996-04-03 2.2 HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
3EKQ 2009-09-01 2.2 Crystal structure of inhibitor saquinavir (SQV) in complex with multi-drug resistant HIV-1 protease (L63P/V82T/I84V) (referred to as ACT in paper)
4DGE 2012-02-08 2.2 TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant, HIV-1 CA(O-loop) complex
1HEF 1994-05-31 2.2 The crystal structures at 2.2 angstroms resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations
5OIA 2018-03-07 2.2 Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
1AID 1997-10-15 2.2 STRUCTURE OF A NON-PEPTIDE INHIBITOR COMPLEXED WITH HIV-1 PROTEASE: DEVELOPING A CYCLE OF STRUCTURE-BASED DRUG DESIGN
1HAR 1995-04-20 2.2 2.2 ANGSTROMS RESOLUTION STRUCTURE OF THE AMINO-TERMINAL HALF OF HIV-1 REVERSE TRANSCRIPTASE (FINGERS AND PALM SUBDOMAINS)
1K6C 2002-02-06 2.2 LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE
1U8G 2004-11-02 2.2 Crystal structure of a HIV-1 Protease in complex with peptidomimetic inhibitor KI2-PHE-GLU-GLU-NH2
1T7J 2005-05-10 2.2 crystal structure of inhibitor amprenavir in complex with a multi-drug resistant variant of HIV-1 protease (L63P/V82T/I84V)
2B7Z 2006-11-14 2.2 Structure of HIV-1 protease mutant bound to indinavir
1K6P 2002-02-06 2.2 LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE
5OI2 2018-03-07 2.2 Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
3EM3 2009-09-01 2.2 Crystal structure of amprenavir (APV) in complex with a drug resistant HIV-1 protease variant (I50L/A71V).
1LZQ 2003-04-29 2.2 Crystal structure of the complex of mutant HIV-1 protease (A71V, V82T, I84V) with an ethylenamine peptidomimetic inhibitor BOC-PHE-PSI[CH2CH2NH]-PHE-GLU-PHE-NH2
6ELI 2018-04-11 2.2 Structure of HIV-1 reverse transcriptase (RT) in complex with rilpivirine and an RNase H inhibitor XZ462
3KDC 2010-03-16 2.2 Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10074
1HEG 1994-05-31 2.2 The crystal structures at 2.2 angstroms resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations
2Q63 2008-02-26 2.2 HIV-1 PR mutant in complex with nelfinavir
6B2J 2018-09-26 2.21 E45A mutant of HIV-1 capsid protein (other crystal form)
4U0F 2014-11-12 2.22 Hexameric HIV-1 CA in Complex with BI-2
1UPJ 1996-10-14 2.22 HIV-1 PROTEASE COMPLEX WITH U095438 [3-[1-(4-BROMOPHENYL) ISOBUTYL]-4-HYDROXYCOUMARIN
6VKV 2020-10-21 2.22 Co-crystal structure of GS-6207 bound to HIV-1 capsid hexamer
6DUG 2018-08-01 2.22 Crystal structure of HIV-1 reverse transcriptase K101P mutant in complex with non-nucleoside inhibitor 25a
3T11 2012-08-22 2.22 Dimeric inhibitor of HIV-1 protease.
5VQZ 2017-08-23 2.23 Crystal Structure of HIV-1 Reverse Transcriptase (K103N, Y181C) Variant in Complex with 2-chloro-N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacetamide (JLJ686), a Non-nucleoside Inhibitor
3LP1 2010-06-09 2.23 HIV-1 reverse transcriptase with inhibitor
6UL5 2020-02-05 2.23 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with 4-[(4-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy}thieno[3,2-d]pyrimidin-2-yl)amino]-2-fluorobenzonitrile (24b), a non-nucleoside RT inhibitor
3TTP 2012-09-26 2.23 Structure of multiresistant HIV-1 protease in complex with darunavir
4O55 2014-07-02 2.24 HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[6-(5-chloro-1H-benzimidazol-2-yl)-2,5-dimethyl-4-phenylpyridin-3-yl]ethanoic acid
2NXM 2007-09-18 2.25 Structure of HIV-1 protease D25N complexed with the rt-rh analogue peptide GLY-ALA-GLN-THR-PHE*TYR-VAL-ASP-GLY-ALA
1K6T 2002-02-06 2.25 LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE
1HVS 1995-02-14 2.25 STRUCTURAL BASIS OF DRUG RESISTANCE FOR THE V82A MUTANT OF HIV-1 PROTEASE: BACKBONE FLEXIBILITY AND SUBSITE REPACKING
3PJ6 2011-04-06 2.25 Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants
3OQA 2011-04-06 2.25 Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants
5W4Q 2018-06-20 2.29 Structure of the R18A/E28A mutant of the HIV-1 capsid protein
1EBY 2002-06-26 2.29 HIV-1 protease in complex with the inhibitor BEA369
1GNO 1996-11-08 2.3 HIV-1 PROTEASE (WILD TYPE) COMPLEXED WITH U89360E (INHIBITOR)
4I2P 2013-01-16 2.3 Crystal structure of HIV-1 reverse transcriptase in complex with rilpivirine (TMC278) based analogue
5D3G 2015-09-30 2.3 Structure of HIV-1 Reverse Transcriptase Bound to a Novel 38-mer Hairpin Template-Primer DNA Aptamer
1TCX 1996-12-07 2.3 HIV TRIPLE MUTANT PROTEASE COMPLEXED WITH INHIBITOR SB203386
2QNQ 2008-04-15 2.3 HIV-1 Protease in complex with a chloro decorated pyrrolidine-based inhibitor
5OI3 2018-03-07 2.3 Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
1HOS 1993-10-31 2.3 INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE BY A C2-SYMMETRIC PHOSPHINATE SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS
1SBG 1994-10-15 2.3 AN ORALLY-BIOAVAILABLE HIV-1 PROTEASE INHIBITOR CONTAINING AN IMIDAZOLE-DERIVED PEPTIDE BOND REPLACEMENT. CRYSTALLOGRAPHIC AND PHARMACOKINETIC ANALYSIS
1GNN 1996-11-08 2.3 HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASN (V82N) COMPLEXED WITH U89360E (INHIBITOR)
4Y1C 2015-02-25 2.3 Cyclic hexapeptide cyc[NdPopPKID] in complex with HIV-1 integrase core domain
1GNM 1996-11-08 2.3 HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASP (V82D) COMPLEXED WITH U89360E (INHIBITOR)
1HYZ 2001-04-04 2.3 HIV INTEGRASE CORE DOMAIN COMPLEXED WITH A DERIVATIVE OF TETRAPHENYL ARSONIUM.
2OPS 2007-05-22 2.3 Crystal Structure of Y188C Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
1YTG 1997-03-12 2.3 SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT
1HPS 1994-08-31 2.3 RATIONAL DESIGN, SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS OF A HYDROXYETHYLENE-BASED HIV-1 PROTEASE INHIBITOR CONTAINING A HETEROCYCLIC P1'-P2' AMIDE BOND ISOSTERE
3MEC 2010-05-12 2.3 HIV-1 Reverse Transcriptase in Complex with TMC125
2RKI 2008-04-22 2.3 Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with a triazole derived NNRTI
1A9M 1998-06-17 2.3 G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E
1HIW 1996-10-14 2.3 TRIMERIC HIV-1 MATRIX PROTEIN
4KV8 2013-07-31 2.3 Crystal structure of HIV RT in complex with BILR0355BS
4HVP 1990-04-15 2.3 Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 Angstroms resolution
3LAK 2010-02-23 2.3 Crystal structure of HIV-1 reverse transcriptase in complex with N1-heterocycle pyrimidinedione non-nucleoside inhibitor
1ZLF 2006-04-25 2.3 Crystal structure of a complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor
6KDN 2020-03-04 2.3 HIV-1 reverse transcriptase with Q151M/Y115F/F116Y:DNA:dGTP ternary complex
1HXB 1997-03-12 2.3 HIV-1 proteinase complexed with RO 31-8959
3DYA 2008-11-25 2.3 HIV-1 RT with non-nucleoside inhibitor annulated Pyrazole 1
6AXR 2018-09-12 2.3 Structure of the P122A mutant of the HIV-1 capsid protein
1ITG 1995-05-08 2.3 CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE: SIMILARITY TO OTHER POLYNUCLEOTIDYL TRANSFERASES
1HBV 1995-07-10 2.3 A CHECK ON RATIONAL DRUG DESIGN. CRYSTAL STRUCTURE OF A COMPLEX OF HIV-1 PROTEASE WITH A NOVEL GAMMA-TURN MIMETIC
4K4P 2013-09-18 2.31 TL-3 inhibited Trp6Ala HIV Protease
2Z54 2008-07-01 2.31 The Influence of I47A Mutation on Reduced Susceptibility to the Protease Inhibitor Lopinavir
6KDM 2020-03-04 2.32 HIV-1 reverse transcriptase with Q151M/Y115F/F116Y:DNA:entecavir 5'-triphosphate ternary complex
6VLM 2020-05-13 2.32 Core Catalytic Domain of HIV Integrase in complex with virtual screening hit
6UM8 2020-03-04 2.33 HIV Integrase in complex with Compound-14
5KGW 2016-10-19 2.34 HIV1 catalytic core domain in complex with inhibitor: (2~{S})-2-[3-(3,4-dihydro-2~{H}-chromen-6-yl)-1-methyl-indol-2-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid
1RTJ 1996-04-03 2.35 MECHANISM OF INHIBITION OF HIV-1 REVERSE TRANSCRIPTASE BY NON-NUCLEOSIDE INHIBITORS
5OI8 2018-03-07 2.35 Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
5VQY 2017-08-23 2.35 Crystal Structure of HIV-1 Reverse Transcriptase (K103N, Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacrylamide (JLJ684), a Non-nucleoside Inhibitor
4EJ8 2013-05-01 2.35 Apo HIV Protease (PR) dimer in closed form with fragment 1F1 in the outside/top of flap
4CPQ 2014-12-17 2.35 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
1AK4 1997-10-15 2.36 HUMAN CYCLOPHILIN A BOUND TO THE AMINO-TERMINAL DOMAIN OF HIV-1 CAPSID
2YNF 2013-01-09 2.36 HIV-1 Reverse Transcriptase Y188L mutant in complex with inhibitor GSK560
4O5B 2014-07-02 2.37 HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[6-(5-chloro-1H-benzimidazol-2-yl)-2,5-dimethyl-4-phenylpyridin-3-yl]ethanoic acid
6ECL 2019-08-21 2.38 Crystal Structure of a 1,2,4-Triazole Allosteric RNase H Inhibitor in Complex with HIV Reverse Transcriptase
5XN2 2018-02-07 2.38 HIV-1 reverse transcriptase Q151M:DNA:dGTP ternary complex
6EWA 2018-11-07 2.39 Crystal structure of HLA-A2 in complex with LILRB1
6AXW 2018-09-12 2.4 Structure of the I124A mutant of the HIV-1 capsid protein
2RF2 2008-01-01 2.4 HIV reverse transcriptase in complex with inhibitor 7e (NNRTI)
1VRU 1996-04-03 2.4 HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
1VIJ 1999-01-13 2.4 HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR HOE/BAY 793 HEXAGONAL FORM
7HVP 1993-07-15 2.4 X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN A SYNTHETIC PROTEASE OF HUMAN IMMUNODEFICIENCY VIRUS 1 AND A SUBSTRATE-BASED HYDROXYETHYLAMINE INHIBITOR
6AYA 2018-09-12 2.4 Structure of the native full-length HIV-1 capsid protein in complex with Nup153 peptide
3DS5 2008-09-02 2.4 HIV-1 capsid C-terminal domain mutant (N183A)
5K14 2016-06-29 2.4 HIV-1 Reverse Transcriptase in complex with a 2,6-difluorophenyl DAPY analog
3T1A 2011-10-26 2.4 Crystal Structure of HIV-1 Reverse Transcriptase (K103N mutant) in Complex with Inhibitor M05
1Q94 2004-06-01 2.4 Structures of HLA-A*1101 in complex with immunodominant nonamer and decamer HIV-1 epitopes clearly reveal the presence of a middle anchor residue
5OI5 2018-03-07 2.4 Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
1HRH 1992-01-15 2.4 CRYSTAL STRUCTURE OF THE RIBONUCLEASE H DOMAIN OF HIV-1 REVERSE TRANSCRIPTASE
6AXS 2018-09-12 2.4 Structure of the V11I/T58A/P122A mutant of the HIV-1 capsid protein
1VIK 1998-12-09 2.4 HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR HOE/BAY 793 ORTHORHOMBIC FORM
1K6Y 2001-12-21 2.4 Crystal Structure of a Two-Domain Fragment of HIV-1 Integrase
6CPO 2018-06-06 2.4 Crystal structure of DR15 presenting the RQ13 peptide
6VRG 2020-09-09 2.4 Structure of HIV-1 integrase with native amino-terminal sequence
4G8G 2013-03-20 2.4 Crystal Structure of C12C TCR-HA B2705-KK10
6O9E 2019-10-23 2.4 Structure of HIV-1 Reverse Transcriptase in complex with DNA and INDOPY-1
6AXT 2018-09-12 2.4 Structure of the T58S/T107I/P122A mutant of the HIV-1 capsid protein
1S1T 2004-06-29 2.4 Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with UC-781
6CQL 2018-06-06 2.4 Crystal structure of F24 TCR -DR11-RQ13 peptide complex
5VQX 2017-08-23 2.4 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with 2-chloro-N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacetamide (JLJ686), a Non-nucleoside Inhibitor
3MEE 2010-05-12 2.4 HIV-1 Reverse Transcriptase in Complex with TMC278
6B2G 2018-09-26 2.41 P38A mutant of HIV-1 capsid protein
4XFX 2015-06-10 2.43 Structure of the native full-length HIV-1 capsid protein
6IK9 2019-01-30 2.43 HIV-1 reverse transcriptase with Q151M/G112S/D113A/Y115F/F116Y/F160L/I159L:DNA:dGTP ternary complex
5J2M 2016-08-03 2.43 HIV-1 reverse transcriptase in complex with DNA and EFdA-triphosphate, a translocation-defective RT inhibitor
2BE2 2005-12-06 2.43 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with R221239
6BSG 2018-01-03 2.44 Structure of HIV-1 RT complexed with RNA/DNA hybrid in an RNA hydrolysis-off mode
4EJL 2013-05-01 2.44 Apo HIV Protease (PR) dimer in closed form with fragment 1F1-N in the outside/top of flap
1M0B 2004-01-13 2.45 HIV-1 protease in complex with an ethyleneamine inhibitor
5XN1 2018-02-07 2.45 HIV-1 reverse transcriptase Q151M:DNA:entecavir-triphosphate ternary complex
4QLH 2014-08-06 2.45 Crystal structure of drug resistant V82S/V1082S HIV-1 Protease
6CPL 2018-06-06 2.45 Crystal structure of DR11 presenting the gag293 epitope
4COE 2014-12-10 2.45 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
4DMN 2012-03-21 2.45 HIV-1 Integrase Catalytical Core Domain
4WE1 2014-12-03 2.49 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ600)
2YNI 2013-01-09 2.49 HIV-1 Reverse Transcriptase in complex with inhibitor GSK952
6AY9 2018-09-12 2.5 Structure of the native full-length HIV-1 capsid protein in complex with CPSF6 peptide
2Q64 2008-02-26 2.5 HIV-1 PR mutant in complex with nelfinavir
1JKH 2001-10-03 2.5 CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
6JCG 2019-07-17 2.5 Room temperature structure of HIV-1 Integrase catalytic core domain by serial femtosecond crystallography.
5VQS 2017-08-23 2.5 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)acrylamide (JLJ685), a Non-nucleoside Inhibitor
2AZ9 2006-02-28 2.5 HIV-1 Protease NL4-3 1X mutant
3P05 2011-01-12 2.5 X-ray structure of pentameric HIV-1 CA
1C1C 2000-07-21 2.5 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-6123
5TSV 2017-11-08 2.5 HIV-1 CA hexamer with NUP153 peptide - R3 crystal form
1JLA 2001-10-03 2.5 CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-651
1AAQ 1994-06-22 2.5 HYDROXYETHYLENE ISOSTERE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE: STRUCTURE-ACTIVITY ANALYSIS USING ENZYME KINETICS, X-RAY CRYSTALLOGRAPHY, AND INFECTED T-CELL ASSAYS
6B2I 2018-09-26 2.5 E45A mutant of the HIV-1 capsid protein
4IG0 2013-02-06 2.5 HIV-1 reverse transcriptase with bound fragment at the 507 site
6CQN 2018-06-06 2.5 Crystal structure of F5 TCR -DR11-RQ13 peptide complex
2HNY 2006-09-05 2.5 Crystal Structure of E138K Mutant HIV-1 Reverse Transcriptase in Complex with Nevirapine
6LMI 2020-09-23 2.5 Crystal structure of HIV-1 integrase catalytic core domain in complex with 2-(tert-butoxy)-2-[3-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methanesulfonamido-2,3',4',5-tetramethyl-[1,1'-biphenyl]-4-yl]acetic acid
1BIU 1998-08-19 2.5 HIV-1 INTEGRASE CORE DOMAIN COMPLEXED WITH MG++
3MED 2010-05-12 2.5 HIV-1 K103N Reverse Transcriptase in Complex with TMC125
4I7F 2013-02-20 2.5 HIV-1 Reverse Transcriptase in complex with a phosphonate analog of nevirapine
1EP4 2000-09-27 2.5 Crystal structure of HIV-1 reverse transcriptase in complex with S-1153
1FK9 2000-11-03 2.5 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
1BI4 1998-11-04 2.5 CATALYTIC DOMAIN OF HIV-1 INTEGRASE
1SH9 2004-10-05 2.5 Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease
6AMO 2018-08-15 2.5 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 7.0
2HND 2006-09-05 2.5 Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with Nevirapine
1HPO 1997-04-21 2.5 HIV-1 PROTEASE TRIPLE MUTANT/U103265 COMPLEX
8HVP 1993-10-31 2.5 STRUCTURE AT 2.5-ANGSTROMS RESOLUTION OF CHEMICALLY SYNTHESIZED HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE COMPLEXED WITH A HYDROXYETHYLENE*-BASED INHIBITOR
2BPZ 1999-02-23 2.5 HIV-1 protease-inhibitor complex
1C1B 2000-07-21 2.5 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GCA-186
5TXL 2017-04-05 2.5 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP
1BDQ 1998-08-12 2.5 HIV-1 (2:31-37, 47, 82) PROTEASE COMPLEXED WITH INHIBITOR SB203386
3N3I 2010-06-09 2.5 Crystal Structure of G48V/C95F tethered HIV-1 Protease/Saquinavir complex
5IM7 2016-10-05 2.5 Crystal structure of HLA-B5801, a protective HLA allele for HIV-1 infection
3AID 1997-09-17 2.5 A NEW CLASS OF HIV-1 PROTEASE INHIBITOR: THE CRYSTALLOGRAPHIC STRUCTURE, INHIBITION AND CHEMICAL SYNTHESIS OF AN AMINIMIDE PEPTIDE ISOSTERE
3ISN 2010-03-16 2.5 Crystal structure of HIV-1 RT bound to A 6-vinylpyrimidine inhibitor
3DLE 2008-08-12 2.5 Crystal structure of hiv-1 reverse transcriptase in complex with GF128590.
1A8G 1998-07-15 2.5 HIV-1 PROTEASE IN COMPLEX WITH SDZ283-910
6AVM 2018-08-15 2.5 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 9.5 WITH CROSS-LINKING TO SECOND BASE TEMPLATE OVERHANG
5VQW 2017-08-23 2.5 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)acrylamide (JLJ685), a Non-nucleoside Inhibitor
3GGA 2009-05-26 2.5 HIV Protease inhibitors with pseudo-symmetric cores
1MTB 2003-01-07 2.5 Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
6X4B 2020-07-22 2.5 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-5-fluoro-8-methyl-2-naphthonitrile (JLJ655), a Non-nucleoside Inhibitor
1D4S 1999-10-12 2.5 HIV-1 PROTEASE V82F/I84V DOUBLE MUTANT/TIPRANAVIR COMPLEX
2IAJ 2006-12-19 2.5 Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with ATP
6KDJ 2020-03-04 2.51 HIV-1 reverse transcriptase with Q151M/Y115F/F116Y:DNA:lamivudine 5'-triphosphate ternary complex
4PQU 2014-06-18 2.51 Crystal structure of HIV-1 Reverse Transcriptase in complex with RNA/DNA and dATP
3TAM 2011-10-26 2.51 Crystal structure of HIV-1 reverse transcriptase (K103N mutant) in complex with inhibitor M06
3LAL 2010-02-23 2.51 Crystal structure of HIV-1 reverse transcriptase in complex with N1-ethyl pyrimidinedione non-nucleoside inhibitor
1C0U 2000-07-19 2.52 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+50.0934
5J2P 2016-08-03 2.53 HIV-1 reverse transcriptase in complex with DNA that has incorporated EFdA-MP at the P-(post-translocation) site and a second EFdA-MP at the N-(pre-translocation) site
6OR7 2019-07-24 2.53 Structure of HIV-1 Reverse Transcriptase (RT) in complex with DNA AND (-)FTC-TP
6WPF 2020-11-04 2.53 Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and d4T
6X4A 2020-07-22 2.54 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with 5-chloro-7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-8-methyl-2-naphthonitrile (JLJ651), a Non-nucleoside Inhibitor
5TXO 2017-04-05 2.55 STRUCTURE OF Q151M complex (A62V, V75I, F77L, F116Y, Q151M) mutant HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP
1RT2 1997-04-21 2.55 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH TNK-651
3IS9 2010-04-07 2.55 Crystal structure of the HIV-1 reverse transcriptase (RT) in complex with the alkenyldiarylmethane (ADAM) Non-nucleoside RT Inhibitor dimethyl 3,3'-(6-methoxy-6-oxohex-1-ene-1,1-diyl)bis(5-cyano-6-methoxybenzoate).
6P1X 2019-07-24 2.55 Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and L-ddCTP
2OPP 2007-05-22 2.55 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with GW420867X.
5VQR 2017-08-23 2.55 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacrylamide (JLJ684), a Non-nucleoside Inhibitor
5TXN 2017-04-05 2.55 STRUCTURE OF Q151M MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP
3LAN 2010-02-23 2.55 Crystal structure of HIV-1 reverse transcriptase in complex with N1-butyl pyrimidinedione non-nucleoside inhibitor
5VQQ 2017-08-23 2.55 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-2-fluoro-N-methylacetamide (JLJ683), a Non-nucleoside Inhibitor
1RT1 1997-04-21 2.55 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH MKC-442
6UJZ 2019-12-25 2.56 HIV-1 wild-type reverse transcriptase-DNA complex with (+)-FTC-TP
5VQT 2017-08-23 2.56 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 2-chloro-N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacetamide (JLJ686), a Non-nucleoside Inhibitor
6KDK 2020-03-04 2.56 HIV-1 reverse transcriptase with Q151M/Y115F/F116Y:DNA:dCTP ternary complex
6KDO 2020-03-04 2.57 HIV-1 reverse transcriptase with Q151M/Y115F/F116Y/M184V/F160M:DNA:lamivudine 5'-triphosphate ternary complex
5VQV 2017-08-23 2.58 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacrylamide (JLJ684), a Non-nucleoside Inhibitor
4NCG 2014-02-12 2.58 Discovery of Doravirine, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses
6ANQ 2018-08-15 2.59 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 8.5
6UJY 2019-12-25 2.59 HIV-1 wild-type reverse transcriptase-DNA complex with (-)-3TC-TP
1REV 1996-10-14 2.6 HIV-1 REVERSE TRANSCRIPTASE
1S1V 2004-06-29 2.6 Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with TNK-651
6AXX 2018-09-12 2.6 Structure of the T58A/I124A mutant of the HIV-1 capsid protein
1JLF 2001-10-03 2.6 CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
3T19 2011-10-26 2.6 Crystal structure of HIV-1 reverse transcriptase (wild type) in complex with inhibitor M05
6AVT 2018-08-15 2.6 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 9.5 WITH CROSS-LINKING TO FIRST BASE TEMPLATE OVERHANG
6X4E 2020-07-22 2.6 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with methyl 2-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)acetate (JLJ681), a Non-nucleoside Inhibitor
1TKT 2004-12-07 2.6 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW426318
3DRP 2008-10-14 2.6 HIV reverse transcriptase in complex with inhibitor R8e
5VQU 2017-08-23 2.6 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-2-fluoro-N-methylacetamide (JLJ683), a Non-nucleoside Inhibitor
4ZHR 2015-11-11 2.6 Structure of HIV-1 RT Q151M mutant
6IKA 2019-01-30 2.6 HIV-1 reverse transcriptase with Q151M/G112S/D113A/Y115F/F116Y/F160L/I159L:DNA:entecavir-triphosphate ternary complex
5C24 2015-07-29 2.6 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 7-((4-((4-cyanophenyl)amino)-1,3,5-triazin-2-yl)amino)-6,8-dimethylindolizine-2-carbonitrile (JLJ605), a non-nucleoside inhibitor
5XN0 2018-02-07 2.6 HIV-1 reverse transcriptase Q151M:DNA binary complex
3FFI 2009-12-15 2.6 HIV-1 RT with pyridone non-nucleoside inhibitor
1JLG 2001-10-03 2.6 CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH UC-781
1FB7 2000-12-13 2.6 CRYSTAL STRUCTURE OF AN IN VIVO HIV-1 PROTEASE MUTANT IN COMPLEX WITH SAQUINAVIR: INSIGHTS INTO THE MECHANISMS OF DRUG RESISTANCE
4WYM 2014-12-17 2.6 Structural basis of HIV-1 capsid recognition by CPSF6
2ITG 1997-03-12 2.6 CATALYTIC DOMAIN OF HIV-1 INTEGRASE: ORDERED ACTIVE SITE IN THE F185H CONSTRUCT
3QO9 2011-05-04 2.6 Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with TSAO-T, a non-nucleoside RT inhibitor (NNRTI)
1A43 1999-02-09 2.6 STRUCTURE OF THE HIV-1 CAPSID PROTEIN DIMERIZATION DOMAIN AT 2.6A RESOLUTION
6AN8 2018-08-15 2.6 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 8.0
6B2H 2018-09-26 2.6 P38A/T216I mutant of the HIV-1 capsid protein
1S9E 2004-05-11 2.6 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R129385
1BAJ 1998-10-14 2.6 HIV-1 CAPSID PROTEIN C-TERMINAL FRAGMENT PLUS GAG P2 DOMAIN
6ASW 2018-08-15 2.61 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 9.0
1LWC 2002-10-30 2.62 CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
6GL1 2018-08-08 2.62 HLA-E*01:03 in complex with the HIV epitope, RL9HIV
4RW6 2015-04-29 2.63 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) variant in complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor
5EU7 2016-09-28 2.64 Crystal structure of HIV-1 integrase catalytic core in complex with Fab
6UIR 2019-12-25 2.64 HIV-1 M184V reverse transcriptase-DNA complex with (-)-FTC-TP
3KLI 2010-09-22 2.65 Crystal structure of unliganded AZT-resistant HIV-1 Reverse Transcriptase
3DI6 2008-08-19 2.65 HIV-1 RT with pyridazinone non-nucleoside inhibitor
6X4D 2020-07-22 2.65 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(cyclopropylmethyl)-7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-8-methyl-2-naphthonitrile (JLJ678), a Non-nucleoside Inhibitor
2B6A 2005-11-01 2.65 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with THR-50
4GW6 2013-05-01 2.65 HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor
1KLM 1998-03-18 2.65 HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH BHAP U-90152
6BSH 2018-01-03 2.65 Structure of HIV-1 RT complexed with RNA/DNA hybrid in the RNA hydrolysis mode
6OUN 2019-07-24 2.66 Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (-)3TC-TP
4RW4 2015-04-29 2.67 Crystal Structure of HIV-1 Reverse Transcriptase (K103N,Y181C) variant in complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor
5KGX 2016-10-19 2.67 HIV1 catalytic core domain in complex with an inhibitor (2~{S})-2-[3-(3,4-dihydro-2~{H}-chromen-6-yl)-1-methyl-indol-2-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid
3M8P 2010-05-19 2.67 HIV-1 RT with NNRTI TMC-125
4KSE 2014-08-13 2.68 Crystal structure of a HIV p51 (219-230) deletion mutant
6BHT 2018-08-01 2.69 HIV-1 CA hexamer in complex with IP6, orthorhombic crystal form
4LSL 2013-12-25 2.69 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-(4-chloro-2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ476), a non-nucleoside inhibitor
5TXP 2017-04-05 2.7 STRUCTURE OF Q151M complex (A62V, V75I, F77L, F116Y, Q151M) mutant HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DDATP
1DLO 1996-08-01 2.7 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
1HHP 1992-10-15 2.7 THE THREE-DIMENSIONAL STRUCTURE OF THE ASPARTYL PROTEASE FROM THE HIV-1 ISOLATE BRU
1S1W 2004-06-29 2.7 Crystal structure of V106A mutant HIV-1 reverse transcriptase in complex with UC-781
3V6D 2012-01-18 2.7 Crystal structure of HIV-1 reverse transcriptase (RT) cross-linked with AZT-terminated DNA
3H4E 2009-06-23 2.7 X-ray Structure of Hexameric HIV-1 CA
5TXM 2017-04-05 2.7 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DDATP
6AN2 2018-08-15 2.7 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 7.5
3GGX 2009-05-26 2.7 HIV Protease, pseudo-symmetric inhibitors
3C6U 2008-04-22 2.7 Crystal Structure of HIV Reverse Transcriptase in complex with inhibitor 22
4I2Q 2013-01-16 2.7 Crystal structure of K103N/Y181C mutant of HIV-1 reverse transcriptase in complex with rilpivirine (TMC278) analogue
5TUQ 2017-06-28 2.7 Crystal Structure of a 6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione Inhibitor in Complex with HIV Reverse Transcriptase
1HQU 2001-05-30 2.7 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
3C6T 2008-04-22 2.7 Crystal Structure of HIV Reverse Transcriptase in complex with inhibitor 14
4XFZ 2015-06-10 2.7 Structure of the native full-length HIV-1 capsid protein in complex with PF-3450074 (PF74)
2FDE 2006-02-21 2.7 Wild type HIV protease bound with GW0385
1C0T 2000-07-19 2.7 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+21.1326
3KK1 2010-03-23 2.7 HIV-1 reverse transcriptase-DNA complex with nuceotide inhibitor GS-9148-diphosphate bound in nucleotide site
6UJX 2019-12-25 2.7 HIV-1 wild-type reverse transcriptase-DNA complex with (-)-FTC-TP
5TER 2017-01-11 2.7 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-chloro-7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-8-methyl-2-naphthonitrile (JLJ651), a Non-nucleoside Inhibitor
1HQE 2001-05-30 2.7 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
3QLH 2011-12-21 2.7 HIV-1 Reverse Transcriptase in Complex with Manicol at the RNase H Active Site and TMC278 (Rilpivirine) at the NNRTI Binding Pocket
3DS3 2008-09-02 2.7 HIV-1 capsid C-terminal domain mutant (Y169A) in complex with an inhibitor of particle assembly (CAI)
3PHV 1992-01-15 2.7 X-RAY ANALYSIS OF HIV-1 PROTEINASE AT 2.7 ANGSTROMS RESOLUTION CONFIRMS STRUCTURAL HOMOLOGY AMONG RETROVIRAL ENZYMES
3I0S 2009-08-25 2.7 crystal structure of HIV reverse transcriptase in complex with inhibitor 7
3M8Q 2010-05-19 2.7 HIV-1 RT with AMINOPYRIMIDINE NNRTI
4O4G 2014-11-05 2.71 Crystal Structure of HIV-1 Reverse Transcriptase in complex with 4-((4-(mesitylamino)-1,3,5-triazin-2-yl)amino)benzonitrile (JLJ527), a non-nucleoside inhibitor
6WPH 2020-11-04 2.72 Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (-)-FTC
6X4F 2020-07-22 2.72 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with methyl 2-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)acetate (JLJ681), a Non-nucleoside Inhibitor
1EET 2001-02-07 2.73 HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH THE INHIBITOR MSC204
6R6Q 2020-05-06 2.73 HIV capsid hexamer with IP5 ligand
6WPJ 2020-11-04 2.73 Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and d4T
6P1I 2019-07-24 2.74 Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and dCTP
6X49 2020-07-22 2.74 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with 7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ649), a Non-nucleoside Inhibitor
6DTW 2019-07-31 2.74 HIV-1 Reverse Transcriptase Y181C Mutant in complex with JLJ 578
6CQJ 2018-06-06 2.75 Crystal structure of DR1 presenting the RQ13 peptide
5HRO 2016-06-01 2.75 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A DNA aptamer and an Alpha-carboxy nucleoside phosphonate inhibitor (alpha-CNP)
6UIS 2019-12-25 2.75 HIV-1 M184V reverse transcriptase-DNA complex with dCTP
5O2U 2017-06-21 2.76 Llama VHH in complex with p24
6UK0 2019-12-25 2.76 HIV-1 M184V reverse transcriptase-DNA complex
3LAM 2010-02-23 2.76 Crystal structure of HIV-1 reverse transcriptase in complex with N1-propyl pyrimidinedione non-nucleoside inhibitor
6AXV 2018-09-12 2.77 Structure of the T58S/T107I/P122A mutant of the HIV-1 capsid protein in complex with PF-3450074 (PF74)
6X47 2020-07-22 2.77 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ649), a Non-nucleoside Inhibitor
6AXY 2018-09-12 2.78 Structure of the V11I/T58A/I124A mutant of the HIV-1 capsid protein
5J2Q 2016-08-03 2.79 HIV-1 reverse transcriptase in complex with DNA that has incorporated a mismatched EFdA-MP at the N-(pre-translocation) site
5XOT 2017-06-14 2.79 Crystal structure of pHLA-B35 in complex with TU55 T cell receptor
4DQG 2012-03-07 2.79 Crystal Structure of apo(G16C/L38C) HIV-1 Protease
3LP0 2010-06-09 2.79 HIV-1 reverse transcriptase with inhibitor
3IG1 2010-01-26 2.8 HIV-1 Reverse Transcriptase with the Inhibitor beta-Thujaplicinol Bound at the RNase H Active Site
1TL3 2004-12-07 2.8 Crystal structure of hiv-1 reverse transcriptase in complex with gw450557
3HVP 1989-10-15 2.8 CONSERVED FOLDING IN RETROVIRAL PROTEASES. CRYSTAL STRUCTURE OF A SYNTHETIC HIV-1 PROTEASE
1HTE 1994-07-31 2.8 X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE
3MEG 2010-05-12 2.8 HIV-1 K103N Reverse Transcriptase in Complex with TMC278
1TV6 2004-07-20 2.8 HIV-1 Reverse Transcriptase Complexed with CP-94,707
4U0B 2014-11-12 2.8 Hexamer HIV-1 CA in complex with CPSF6 peptide, P212121 crystal form
3V4I 2012-01-18 2.8 Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and AZTTP
1S1X 2004-06-29 2.8 Crystal structure of V108I mutant HIV-1 reverse transcriptase in complex with nevirapine
2BPW 1999-02-23 2.8 HIV-1 protease-inhibitor complex
2VG5 2007-12-11 2.8 Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors
3IRX 2010-04-07 2.8 Crystal Structure of HIV-1 reverse transcriptase (RT) in complex with the Non-nucleoside RT Inhibitor (E)-S-Methyl 5-(1-(3,7-Dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-5-(5-methyl-1,3,4-oxadiazol-2-yl)pent-1-enyl)-2-methoxy-3-methylbenzothioate.
1RT6 1999-07-29 2.8 HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC38
6PUY 2020-02-12 2.8 Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and INSTI XZ426 (compound 4d)
1HNI 1995-06-03 2.8 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN A COMPLEX WITH THE NONNUCLEOSIDE INHIBITOR ALPHA-APA R 95845 AT 2.8 ANGSTROMS RESOLUTION
2BPX 1999-02-23 2.8 HIV-1 protease-inhibitor complex
2OPQ 2007-05-22 2.8 Crystal Structure of L100I Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
1EX4 2000-06-07 2.8 HIV-1 INTEGRASE CATALYTIC CORE AND C-TERMINAL DOMAIN
1IKX 2001-06-06 2.8 K103N Mutant HIV-1 Reverse Transcriptase in Complex with the Inhibitor PNU142721
1RDH 1994-05-31 2.8 CRYSTALLOGRAPHIC ANALYSES OF AN ACTIVE HIV-1 RIBONUCLEASE H DOMAIN SHOW STRUCTURAL FEATURES THAT DISTINGUISH IT FROM THE INACTIVE FORM
1LWF 2002-10-30 2.8 CRYSTAL STRUCTURE OF A MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMQ+M184V: M41L/D67N/K70R/M184V/T215Y) IN COMPLEX WITH NEVIRAPINE
3LP3 2010-06-09 2.8 p15 HIV RNaseH domain with inhibitor MK3
3S85 2012-04-11 2.8 Discovery of New HIV Protease Inhibitors with Potential for Convenient Dosing and Reduced Side Effects: A-790742 and A-792611.
1JLE 2001-10-03 2.8 CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE
6CQQ 2018-06-06 2.8 Crystal structure of F24 TCR -DR15-RQ13 peptide complex
2HMI 1998-10-14 2.8 HIV-1 REVERSE TRANSCRIPTASE/FRAGMENT OF FAB 28/DNA COMPLEX
3LP2 2010-06-09 2.8 HIV-1 reverse transcriptase with inhibitor
3ITH 2010-03-16 2.8 Crystal structure of the HIV-1 reverse transcriptase bound to a 6-vinylpyrimidine inhibitor
4XFY 2015-06-10 2.8 Structure of the native full-length dehydrated HIV-1 capsid protein
1DTQ 2000-03-20 2.8 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-1 (PETT131A94)
1S9G 2004-05-11 2.8 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R120394.
6PUZ 2020-02-12 2.8 Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and INSTI XZ446 (compound 4f)
1BDR 1998-10-14 2.8 HIV-1 (2: 31, 33-37) PROTEASE COMPLEXED WITH INHIBITOR SB203386
9HVP 1992-04-15 2.8 Design, activity and 2.8 Angstroms crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease
1BDL 1998-08-12 2.8 HIV-1 (2:31-37) PROTEASE COMPLEXED WITH INHIBITOR SB203386
1LW0 2002-10-30 2.8 CRYSTAL STRUCTURE OF T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
2WON 2010-08-11 2.8 Crystal Structure of UK-453061 bound to HIV-1 Reverse Transcriptase (wild-type).
1R0A 2004-08-03 2.8 Crystal structure of HIV-1 reverse transcriptase covalently tethered to DNA template-primer solved to 2.8 angstroms
1TKZ 2004-12-07 2.81 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW429576
6BHJ 2018-10-31 2.81 Structure of HIV-1 Reverse Transcriptase Bound to a 38-mer Hairpin Template-Primer RNA-DNA Aptamer
6UIT 2019-12-25 2.81 HIV-1 wild-type reverse transcriptase-DNA complex with dCTP
1LWE 2002-10-30 2.81 CRYSTAL STRUCTURE OF M41L/T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMN) IN COMPLEX WITH NEVIRAPINE
2VG7 2007-12-11 2.82 Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors
5C25 2015-07-29 2.84 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 6-((4-((4-cyanophenyl)amino)-1,3,5-triazin-2-yl)amino)-5,7-dimethyl-2-naphthonitrile (JLJ639), a Non-nucleoside Inhibitor
5TW3 2017-03-15 2.85 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)-4-fluorophenoxy)-7-fluoro-2-naphthonitrile (JLJ636), a Non-nucleoside Inhibitor
4H4M 2012-12-05 2.85 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor
1TKX 2004-12-07 2.85 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745
3V81 2012-01-18 2.85 Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and the nonnucleoside inhibitor nevirapine
1QE1 1999-08-30 2.85 CRYSTAL STRUCTURE OF 3TC-RESISTANT M184I MUTANT OF HIV-1 REVERSE TRANSCRIPTASE
6X4C 2020-07-22 2.86 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)-4-fluorophenoxy)-5,8-dimethyl-2-naphthonitrile (JLJ658), a Non-nucleoside Inhibitor
6OTZ 2019-07-24 2.86 Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (+)FTC-TP
4RW8 2015-04-29 2.88 Crystal Structure of HIV-1 Reverse Transcriptase in complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ532), a non-nucleoside inhibitor'
4MFB 2013-11-06 2.88 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)indolizine-2-carbonitrile (JLJ555), a non-nucleoside inhibitor
5V5M 2017-06-14 2.88 Crystal structure of HLA-B*5701 complex with HIV-1 gag derived peptide TW10
4R5P 2015-03-11 2.89 Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and a nucleoside triphosphate mimic alpha-carboxy nucleoside phosphonate inhibitor
6BSJ 2018-01-03 2.89 Structure of HIV-1 RT complexed with an RNA/DNA hybrid sequence non-preferred for RNA hydrolysis
4O44 2014-05-21 2.89 Crystal Structure of HIV-1 Reverse Transcriptase in complex with 4-((4-(mesitylamino)-6-(3-morpholinopropoxy)-1,3,5-triazin-2-yl)amino)benzonitrile (JLJ529), a non-nucleoside inhibitor
4KKO 2013-08-14 2.89 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 4-((4-methoxy-6-(2-morpholinoethoxy)-1,3,5-triazin-2-yl)amino)-2-((3-methylbut-2-en-1-yl)oxy)benzonitrile (JLJ513), a non-nucleoside inhibitor
3DRR 2008-10-14 2.89 HIV reverse transcriptase Y181C mutant in complex with inhibitor R8e
2ZE2 2008-02-12 2.9 Crystal structure of L100I/K103N mutant HIV-1 reverse transcriptase (RT) in complex with TMC278 (rilpivirine), a non-nucleoside RT inhibitor
1KJ4 2002-03-06 2.9 SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES
3KK2 2010-03-23 2.9 HIV-1 reverse transcriptase-DNA complex with dATP bound in the nucleotide binding site
5J2N 2016-08-03 2.9 HIV-1 reverse transcriptase in complex with DNA that has incorporated EFdA-MP at the P-(post-translocation) site and dTMP at the N-(pre-translocation) site
4PUO 2014-06-18 2.9 Crystal structure of HIV-1 reverse transcriptase in complex with RNA/DNA and Nevirapine
3HVT 1994-10-15 2.9 STRUCTURAL BASIS OF ASYMMETRY IN THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE HETERODIMER
2B5J 2005-12-06 2.9 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with JANSSEN-R165481
6PUW 2020-02-12 2.9 Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and Bictegravir (BIC)
4H4O 2012-12-05 2.9 Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with (E)-3-(3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)- 4-fluorophenoxy)-5-fluorophenyl)acrylonitrile (JLJ506), A Non-nucleoside inhibitor
2YNH 2013-01-09 2.9 HIV-1 Reverse Transcriptase in complex with inhibitor GSK500
3DOK 2008-08-12 2.9 Crystal structure of K103N mutant HIV-1 reverse transcriptase in complex with GW678248.
1FKO 2000-11-03 2.9 CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
3KK3 2010-03-23 2.9 HIV-1 reverse transcriptase-DNA complex with GS-9148 terminated primer
1TL1 2004-12-07 2.9 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW451211
6PUT 2020-02-12 2.9 Structure of HIV cleaved synaptic complex (CSC) intasome bound with calcium
6OE3 2019-05-15 2.9 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-7-fluoro-2-naphthonitrile (JLJ635), a Non-nucleoside Inhibitor
5HP1 2016-06-01 2.9 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A DNA aptamer and FOSCARNET, a Pyrophosphate analog
1SV5 2004-05-11 2.9 CRYSTAL STRUCTURE OF K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R165335
1FKP 2000-11-03 2.9 CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
2OPR 2007-05-22 2.9 Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
3KLH 2010-09-22 2.9 Crystal structure of AZT-Resistant HIV-1 Reverse Transcriptase crosslinked to post-translocation AZTMP-Terminated DNA (COMPLEX P)
2YKM 2011-08-17 2.9 Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with a Difluoromethylbenzoxazole (DFMB) Pyrimidine Thioether derivative, a non-nucleoside RT inhibitor (NNRTI)
5J1E 2016-06-15 2.9 Crystal Structure of a Hydroxypyridone Carboxylic Acid Active-Site RNase H Inhibitor in Complex with HIV Reverse Transcriptase
1RT5 1999-07-29 2.9 HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC10
1RT4 1999-07-29 2.9 HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC781
1S6P 2004-05-11 2.9 CRYSTAL STRUCTURE OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R100943
3NBP 2010-08-18 2.95 HIV-1 reverse transcriptase with aminopyrimidine inhibitor 2
3E01 2008-11-25 2.95 HIV-RT with non-nucleoside inhibitor annulated pyrazole 2
2BAN 2005-12-06 2.95 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with JANSSEN-R157208
5HLF 2016-02-10 2.95 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A 38-MER HAIRPIN TEMPLATE-PRIMER DNA APTAMER AND AN ALPHA-CARBOXYPHOSPHONATE INHIBITOR
6OBH 2019-08-28 2.96 Structure of HIV-1 CA 1/2-hexamer
3I0R 2009-08-25 2.98 crystal structure of HIV reverse transcriptase in complex with inhibitor 3
6P2G 2019-07-24 2.99 Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and D-ddCTP
4RW9 2015-04-29 2.99 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) variant in complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ532), a non-nucleoside inhibitor
1JLQ 2001-08-22 3.0 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH 739W94
4U0D 2014-11-12 3.0 Hexameric HIV-1 CA in complex with Nup153 peptide, P212121 crystal form
4PWD 2014-06-18 3.0 Crystal structure of HIV-1 reverse transcriptase in complex with bulge-RNA/DNA and Nevirapine
1HYS 2001-03-26 3.0 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A POLYPURINE TRACT RNA:DNA
5I3U 2016-06-01 3.0 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE N-SITE COMPLEX; CATALYTIC INCORPORATION OF AZTMP to A DNA aptamer in CRYSTAL
1IKV 2001-06-06 3.0 K103N Mutant HIV-1 Reverse Transcriptase in Complex with Efivarenz
1S1U 2004-06-29 3.0 Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with nevirapine
3JSM 2009-09-29 3.0 K65R mutant HIV-1 reverse transcriptase cross-linked to DS-DNA and complexed with tenofovir-diphosphate as the incoming nucleotide substrate
2IC3 2006-12-19 3.0 Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with Nonnucleoside Inhibitor HBY 097
1SUQ 2004-05-11 3.0 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R185545
1HNV 1995-07-10 3.0 STRUCTURE OF HIV-1 RT(SLASH)TIBO R 86183 COMPLEX REVEALS SIMILARITY IN THE BINDING OF DIVERSE NONNUCLEOSIDE INHIBITORS
1HPZ 2001-05-30 3.0 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
1RT3 1999-02-16 3.0 AZT DRUG RESISTANT HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH 1051U91
2HVP 1989-04-19 3.0 THREE-DIMENSIONAL STRUCTURE OF ASPARTYL PROTEASE FROM HUMAN IMMUNODEFICIENCY VIRUS HIV-1
1IKY 2001-06-06 3.0 HIV-1 Reverse Transcriptase in Complex with the Inhibitor MSC194
5W5W 2018-06-20 3.0 HIV Protease (PR) in open form with Mg2+ in active site and HIVE-9 in eye site
1E28 2000-09-12 3.0 Nonstandard peptide binding of HLA-B*5101 complexed with HIV immunodominant epitope KM2(TAFTIPSI)
1RT7 1999-07-29 3.0 HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC84
1S6Q 2004-05-11 3.0 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R147681
1TVR 1997-03-12 3.0 HIV-1 RT/9-CL TIBO
1RTI 1996-04-03 3.0 HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
1N6Q 2003-01-14 3.0 HIV-1 Reverse Transcriptase Crosslinked to pre-translocation AZTMP-terminated DNA (complex N)
1JLC 2001-10-03 3.0 CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-2
1LW2 2002-10-30 3.0 CRYSTAL STRUCTURE OF T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH 1051U91
1T05 2004-05-11 3.0 HIV-1 reverse transcriptase crosslinked to template-primer with tenofovir-diphosphate bound as the incoming nucleotide substrate
1YT9 2005-04-12 3.0 HIV Protease with oximinoarylsulfonamide bound
1DTT 2000-04-02 3.0 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-2 (PETT130A94)
1JLB 2001-10-03 3.0 CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
1AUM 1998-01-14 3.0 HIV CAPSID C-TERMINAL DOMAIN (CAC146)
1IKW 2001-06-06 3.0 Wild Type HIV-1 Reverse Transcriptase in Complex with Efavirenz
5UV5 2017-08-16 3.0 Crystal Structure of a 2-Hydroxyisoquinoline-1,3-dione RNase H Active Site Inhibitor with Multiple Binding Modes to HIV Reverse Transcriptase
2UPJ 1996-10-14 3.0 HIV-1 PROTEASE COMPLEX WITH U100313 ([3-[[3-[CYCLOPROPYL [4-HYDROXY-2OXO-6-[1-(PHENYLMETHYL)PROPYL]-2H-PYRAN-3-YL] METHYL]PHENYL]AMINO]-3-OXO-PROPYL]CARBAMIC ACID TERT-BUTYL ESTER)
2HNZ 2006-09-05 3.0 Crystal Structure of E138K Mutant HIV-1 Reverse Transcriptase in Complex with PETT-2
2VG6 2007-12-11 3.01 Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors
4RW7 2015-04-29 3.01 Crystal Structure of HIV-1 Reverse Transcriptase (K103N, Y181C) variant in complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ532), a non-nucleoside inhibitor
6CQR 2018-06-06 3.04 Crystal structure of F24 TCR -DR1-RQ13 peptide complex
5HBM 2016-02-24 3.04 Crystal Structure of a Dihydroxycoumarin RNase H Active-Site Inhibitor in Complex with HIV-1 Reverse Transcriptase
3GGV 2009-05-26 3.09 HIV Protease, pseudo-symmetric inhibitors
5FDL 2016-02-17 3.1 Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with IDX899
1FQX 2001-03-14 3.1 CRYSTAL STRUCTURE OF THE COMPLEX OF HIV-1 PROTEASE WITH A PEPTIDOMIMETIC INHIBITOR
4LSN 2013-12-25 3.1 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-bromo-5-(4-chloro-2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ518), a non-nucleoside inhibitor
1BQM 1999-01-06 3.1 HIV-1 RT/HBY 097
1N5Y 2003-01-28 3.1 HIV-1 Reverse Transcriptase Crosslinked to Post-Translocation AZTMP-Terminated DNA (Complex P)
3W39 2013-02-13 3.1 Crystal structure of HLA-B*5201 in complexed with HIV immunodominant epitope (TAFTIPSI)
3KJV 2010-03-23 3.1 HIV-1 reverse transcriptase in complex with DNA
5HGL 2016-08-10 3.1 Hexameric HIV-1 CA, open conformation
1T03 2004-05-11 3.1 HIV-1 reverse transcriptase crosslinked to tenofovir terminated template-primer (complex P)
2I5J 2006-12-05 3.15 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with DHBNH, an RNASE H inhibitor
3KLF 2010-09-22 3.15 Crystal structure of wild-type HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA
3DRS 2008-10-14 3.15 HIV reverse transcriptase K103N mutant in complex with inhibitor R8D
6MQA 2019-06-19 3.2 Structure of HIV-1 CA P207S
2WOM 2010-08-11 3.2 Crystal Structure of UK-453061 bound to HIV-1 Reverse Transcriptase (K103N).
1UWB 1997-05-15 3.2 TYR 181 CYS HIV-1 RT/8-CL TIBO
1RTD 1998-12-09 3.2 STRUCTURE OF A CATALYTIC COMPLEX OF HIV-1 REVERSE TRANSCRIPTASE: IMPLICATIONS FOR NUCLEOSIDE ANALOG DRUG RESISTANCE
1HMV 1995-03-31 3.2 THE STRUCTURE OF UNLIGANDED REVERSE TRANSCRIPTASE FROM THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
3KLE 2010-09-22 3.2 Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA
6MQO 2019-06-19 3.2 Structure of HIV-1 CA G208R
6BSI 2018-01-03 3.25 Structure of HIV-1 RT complexed with an RNA/DNA hybrid containing the polypurine-tract sequence
1BQN 1999-01-06 3.3 TYR 188 LEU HIV-1 RT/HBY 097
4B3O 2013-01-16 3.3 Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface
5I42 2016-06-01 3.3 Structure of HIV-1 Reverse Transcriptase in complex with a DNA aptamer, AZTTP, and CA(2+) ion
4Q0B 2014-06-18 3.3 Crystal structure of HIV-1 reverse transcriptase in complex with gap-RNA/DNA and Nevirapine
3JYT 2009-10-06 3.3 K65R mutant HIV-1 reverse transcriptase cross-linked to DS-DNA and complexed with DATP as the incoming nucleotide substrate
6MQP 2019-06-19 3.3 Structure of HIV-1 CA T210K
6DTX 2019-07-31 3.33 Wildtype HIV-1 Reverse Transcriptase in complex with JLJ 578
6BJ2 2018-07-25 3.35 TCR589 in complex with HIV(Pol448-456)/HLA-B35
1P7Q 2003-10-14 3.4 Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor
6V3K 2020-02-12 3.4 Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and INSTI XZ419 (compound 4c)
6ECN 2019-08-21 3.4 HIV-1 CA 1/2-hexamer-EE
6EC2 2019-08-21 3.4 Structure of HIV-1 CA 1/3-hexamer
5C42 2015-11-11 3.5 Crystal Structure of HIV-1 Reverse Transcriptase (K101P) Variant in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)indolizine-2-carbonitrile (JLJ555), a non-nucleoside inhibitor
1J5O 2002-06-14 3.5 CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE-PRIMER
6SKK 2020-08-26 3.6 Structure of the native full-length HIV-1 capsid protein in helical assembly (-13,8)
3KLG 2010-09-22 3.65 Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to pre-translocation AZTMP-Terminated DNA (COMPLEX N)
1AFV 1997-08-20 3.7 HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3
5U1C 2017-01-11 3.9 Structure of tetrameric HIV-1 Strand Transfer Complex Intasome
5L93 2016-07-13 3.9 An atomic model of HIV-1 CA-SP1 reveals structures regulating assembly and maturation
6HAK 2019-04-03 3.95 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with a double stranded RNA represents the RT transcription initiation complex prior to nucleotide incorporation
3DTJ 2008-09-02 4.0 HIV-1 capsid C-terminal domain mutant (E187A)
6WAZ 2020-06-24 4.1 +1 extended HIV-1 reverse transcriptase initiation complex core (pre-translocation state)
6WB0 2020-06-24 4.2 +3 extended HIV-1 reverse transcriptase initiation complex core (pre-translocation state)
6ECO 2019-09-18 4.2 Hexamer-2-Foldon HIV-1 capsid platform
6SLQ 2020-09-09 4.4 Structure of the native full-length HIV-1 capsid protein A92E in helical assembly (-12,11)
6SKN 2020-08-26 4.5 Structure of the native full-length HIV-1 capsid protein in helical assembly (-13,8)
6B19 2018-04-25 4.5 Architecture of HIV-1 reverse transcriptase initiation complex core
6VDK 2020-02-05 4.5 CryoEM structure of HIV-1 conserved Intasome Core
6WB2 2020-06-24 4.5 +3 extended HIV-1 reverse transcriptase initiation complex core (displaced state)
6U8Q 2020-02-05 4.67 CryoEM structure of HIV-1 cleaved synaptic complex (CSC) intasome
6SLU 2020-09-09 4.7 Structure of the native full-length HIV-1 capsid protein A92E in helical assembly (-13,11)
6WB1 2020-06-24 4.7 +3 extended HIV-1 reverse transcriptase initiation complex core (intermediate state)
1HVU 1999-01-13 4.75 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE COMPLEXED WITH A 33-BASE NUCLEOTIDE RNA PSEUDOKNOT
4B3P 2013-01-16 4.84 Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface
6SKM 2020-08-26 4.9 Structure of the native full-length HIV-1 capsid protein A92E in helical assembly (-13,12)
5UPW 2017-03-01 5.0 CryoEM Structure Refinement by Integrating NMR Chemical Shifts with Molecular Dynamics Simulations
6SMU 2020-09-09 5.0 Structure of the native full-length HIV-1 capsid protein in helical assembly (-13,12)
4B3Q 2013-01-16 5.0 Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface
3P0A 2011-01-12 5.95 X-ray structure of pentameric HIV-1 CA
6VWS 2020-10-21 6.08 Hexamer of Helical HIV capsid by RASTR method
3GV2 2009-06-23 7.0 X-ray Structure of Hexameric HIV-1 CA

Relevant UniProtKB Entries

Percent Identity Matching Chains Protein Accession Entry Name
97.3 Gag-Pol polyprotein P04586 POL_HV1Z6
93.1 Gag-Pol polyprotein P05889 GAG_HV1W2
92.2 Gag-Pol polyprotein P12493 GAG_HV1N5
93.8 Gag-Pol polyprotein P12498 POL_HV1J3
94.4 Gag-Pol polyprotein P05960 POL_HV1C4
92.8 Gag-Pol polyprotein P04589 POL_HV1EL
93.2 Gag-Pol polyprotein P05961 POL_HV1MN
93.7 Gag-Pol polyprotein P18802 POL_HV1ND
93.9 Gag-Pol polyprotein P12499 POL_HV1Z2
94.6 Gag-Pol polyprotein P05959 POL_HV1RH
94.4 Gag-Pol polyprotein P04587 POL_HV1B5
94.4 Gag-Pol polyprotein P20875 POL_HV1JR
96.1 Gag-Pol polyprotein P03369 POL_HV1A2
94.5 Gag-Pol polyprotein P03366 POL_HV1B1
95.0 Gag-Pol polyprotein P03367 POL_HV1BR
96.2 Gag-Pol polyprotein Q73368 POL_HV1B9
95.3 Gag-Pol polyprotein P20892 POL_HV1OY
95.5 Gag-Pol polyprotein P0C6F2 POL_HV1LW
95.5 Gag-Pol polyprotein P04585 POL_HV1H2
97.0 Gag-Pol polyprotein P35963 POL_HV1Y2
100.0 Gag-Pol polyprotein P12497 POL_HV1N5