Mapping the transition state and pathway of protein folding by protein engineering.


Abstract

In the transition state for unfolding of barnase, the hydrophobic core between the major alpha-helix and beta-sheet is somewhat weakened, the C terminus of the major helix is largely intact but its N terminus is exposed and a major loop has been invaded by solvent. Study holds ProTherm entries: 1977, 1978, 1979, 1980, 1981, 1982, 1983, 1984, 1985, 1986 Extra Details: hydrophobic core; barnase; protein folding; beta-sheet;,alpha-helix; protein engineering; transition state

Submission Details

ID: J6XkLGUV

Submitter: Connie Wang

Submission Date: April 24, 2018, 8:18 p.m.

Version: 1

Publication Details
Matouschek A;Kellis JT;Serrano L;Fersht AR,Nature (1989) Mapping the transition state and pathway of protein folding by protein engineering. PMID:2739734
Additional Information

Sequence Assay Result Units