Evaluation of the energetic contribution of an ionic network to beta-sheet stability.


Abstract

We have evaluated the interaction energy of a three-residue ionic network constructed on the beta-sheet surface of protein G using double mutant cycles. Although the two individual ion pairs were each stabilizing by 0.6 kcal/mol, the excess gain in stability for the triad was small (0.06 kcal/mol). Study holds ProTherm entries: 12839, 12840, 12841, 12842, 12843, 12844, 12845, 12846, 12847, 12848, 12849, 12850, 12851, 12852, 12853, 12854 Extra Details: beta-sheet; protein stability; protein design; electrostatics; side chain,interactions

Submission Details

ID: EXbrF2br3

Submitter: Connie Wang

Submission Date: April 24, 2018, 8:44 p.m.

Version: 1

Publication Details
Lassila KS;Datta D;Mayo SL,Protein Sci. (2002) Evaluation of the energetic contribution of an ionic network to beta-sheet stability. PMID:11847291
Additional Information

Sequence Assay Result Units