Probing the native strain iin alpha1-antitrypsin.


Abstract

Study holds ProTherm entries: 9330, 9331, 9332, 9333, 9334, 9335, 9336, 9337, 9338, 9339 Extra Details: additive : EDTA(1 mM), thermostable; hydrophobic core; metastable protein

Submission Details

ID: EDozh3Qs3

Submitter: Connie Wang

Submission Date: April 24, 2018, 8:37 p.m.

Version: 1

Publication Details
Lee KN;Park SD;Yu MH,Nat. Struct. Biol. (1996) Probing the native strain iin alpha1-antitrypsin. PMID:8646533
Additional Information

Structure view and single mutant data analysis

Study data

No weblogo for data of varying length.
Colors: D E R H K S T N Q A V I L M F Y W C G P
 

Data Distribution

Studies with similar sequences (approximate matches)

Correlation with other assays (exact sequence matches)


Relevant PDB Entries

Structure ID Release Date Resolution Structure Title
1ATU 1997-05-11T00:00:00+0000 2.7 UNCLEAVED ALPHA-1-ANTITRYPSIN
1D5S 1999-10-11T00:00:00+0000 3.0 CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER
1D5S 1999-10-11T00:00:00+0000 3.0 CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER
1EZX 2000-05-12T00:00:00+0000 2.6 CRYSTAL STRUCTURE OF A SERPIN:PROTEASE COMPLEX
1EZX 2000-05-12T00:00:00+0000 2.6 CRYSTAL STRUCTURE OF A SERPIN:PROTEASE COMPLEX
1HP7 2000-12-12T00:00:00+0000 2.1 A 2.1 ANGSTROM STRUCTURE OF AN UNCLEAVED ALPHA-1-ANTITRYPSIN SHOWS VARIABILITY OF THE REACTIVE CENTER AND OTHER LOOPS
1IZ2 2002-09-19T00:00:00+0000 2.2 Interactions causing the kinetic trap in serpin protein folding
1KCT 1996-08-06T00:00:00+0000 3.46 ALPHA1-ANTITRYPSIN
1OO8 2003-03-03T00:00:00+0000 2.65 CRYSTAL STRUCTURE OF A1PI-PITTSBURGH IN THE NATIVE CONFORMATION
1OPH 2003-03-05T00:00:00+0000 2.3 NON-COVALENT COMPLEX BETWEEN ALPHA-1-PI-PITTSBURGH AND S195A TRYPSIN

Relevant UniProtKB Entries

Percent Identity Matching Chains Protein Accession Entry Name
93.1 Alpha-1-antitrypsin O00394 A1AT_CHLAE
92.4 Alpha-1-antitrypsin P01010 A1AT_PAPAN
96.4 Alpha-1-antitrypsin Q5RCW5 A1AT_PONAB
100.0 Alpha-1-antitrypsin P01009 A1AT_HUMAN