Class I MHC is stabilized against thermal denaturation by physiological concentrations of NaCl.


Abstract

Class I MHC molecules are ternary complexes composed of an allotype specific heavy chain, a noncovalently associated protein beta(2)-microglobulin (beta(2)m), and a peptide. The complexes are assembled in the endoplasmic reticulum by a complex series of chaperones and peptide-loading mechanisms. In the absence of beta(2)m or peptide, very little class I heavy chain is transported to the surface of the cell. Complexes that do not contain all three parts of the protein are not made productively in vivo and not at all in vitro. The ability of the complex to withstand thermal denaturation in vitro has been shown to be related to the binding affinity of the peptide. Paradoxically, some low-affinity peptide complexes denature at or below human basal body temperatures in vitro but are effective biological agents in vivo. Here we show that these complexes are stabilized against thermal denaturation by physiological cosolvents and maximally stabilized by 150 mM NaCl. While the degree of stabilization by 150 mM NaCl is greatest for low-affinity peptide/MHC complexes, the mechanism of stabilization is independent of peptide sequence. This effect is hypothesized to occur by multiple mechanisms including increasing the affinity of beta(2)m for the complex and charge screening. Study holds ProTherm entries: 8533, 8534, 8535, 8536, 8537, 8538, 8539, 8540, 8541, 8542, 8543, 8544, 8545, 8546, 8547, 8548, 8549, 8550, 8551, 8552, 8553, 8554, 8555, 8556, 8557, 8558 Extra Details: The peptide is IISAVVGIL chaperones; peptide-loading mechanisms; binding affinity;,peptide; charge screening

Submission Details

ID: BW9QVoo7

Submitter: Connie Wang

Submission Date: April 24, 2018, 8:36 p.m.

Version: 1

Publication Details
Batalia MA;Kirksey TJ;Sharma A;Jiang L;Abastado JP;Yan S;Zhao R;Collins EJ,Biochemistry (2000) Class I MHC is stabilized against thermal denaturation by physiological concentrations of NaCl. PMID:10913316
Additional Information

Structure view and single mutant data analysis

Study data

No weblogo for data of varying length.
Colors: D E R H K S T N Q A V I L M F Y W C G P
 

Data Distribution

Studies with similar sequences (approximate matches)

Correlation with other assays (exact sequence matches)


Relevant PDB Entries

Structure ID Release Date Resolution Structure Title
1LK2 2003-11-11 1.35 1.35A crystal structure of H-2Kb complexed with the GNYSFYAL peptide
1G7P 2002-07-17 1.5 CRYSTAL STRUCTURE OF MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND YEAST ALPHA-GLUCOSIDASE
1KPU 2003-06-10 1.5 High resolution crystal structure of the MHC class I complex H-2Kb/VSV8
5WEU 2017-10-18 1.58 Crystal Structure of H2-Dd with disulfide-linked 10mer peptide
3G08 2009-12-08 1.6 Crystal structure of the alpha-galactosylceramide analog OCH in complex with mouse CD1d
1G7Q 2002-07-17 1.6 CRYSTAL STRUCTURE OF MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND MUC1 VNTR PEPTIDE SAPDTRPA
3GMO 2009-11-10 1.6 Structure of mouse CD1d in complex with C8PhF
3UO1 2012-07-25 1.64 Structure of a monoclonal antibody complexed with its MHC-I antigen
3V4U 2012-07-25 1.64 Structure of a monoclonal antibody complexed with its MHC-I antigen
6C6F 2019-01-30 1.67 Structure of glycolipid aGSA[26,P5p] in complex with mouse CD1d
3GMN 2009-11-10 1.7 Structure of mouse CD1d in complex with C10Ph
3ECB 2009-07-14 1.7 Crystal structure of mouse H-2Dd in complex with peptide P18-I10 derived from human immunodeficiency virus envelope glycoprotein 120
3GML 2009-11-10 1.7 Structure of mouse CD1d in complex with C6Ph
3V52 2012-07-25 1.7 Structure of a monoclonal antibody complexed with its MHC-I antigen
3UYR 2012-07-25 1.7 Structure of a monoclonal antibody complexed with its MHC-I antigen
3T1F 2011-09-21 1.7 Crystal structure of the mouse CD1d-Glc-DAG-s2 complex
1FZK 2001-03-28 1.7 MHC CLASS I NATURAL MUTANT H-2KBM1 HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND SENDAI VIRUS NUCLEOPROTEIN
3GMP 2009-11-10 1.7 Structure of mouse CD1d in complex with PBS-25
1KPV 2003-06-10 1.71 High resolution crystal structure of the MHC class I complex H-2Kb/SEV9
5TW2 2017-09-20 1.75 Structure of mouse CD1d with bound alpha-galactosylsphingamide JG168
1LEG 2002-06-19 1.75 Crystal Structure of H-2Kb bound to the dEV8 peptide
5M02 2017-12-20 1.75 Crystal structure of murine P14 TCR / H-2Db with PF, modified gp33 peptide from LCMV
6GB6 2019-03-06 1.78 Structure of H-2Kb with dipeptide GL
6C6J 2019-01-30 1.79 Structure of glycolipid aGSA[8,P5p] in complex with mouse CD1d
3GMQ 2009-11-10 1.8 Structure of mouse CD1d expressed in SF9 cells, no ligand added
3GMM 2009-11-10 1.8 Structure of mouse CD1d in complex with C8Ph
2ZSV 2008-11-04 1.8 Crystal structure of H-2Kb in complex with JHMV epitope S598
1T0N 2004-11-23 1.8 Conformational switch in polymorphic H-2K molecules containing an HSV peptide
1FZM 2001-03-28 1.8 MHC CLASS I NATURAL MUTANT H-2KBM8 HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND VESICULAR STOMATITIS VIRUS NUCLEOPROTEIN
2QRT 2007-11-06 1.8 Crystal Structure of a disulfide trapped single chain trimer composed of the MHC I heavy chain H-2Kb Y84C, beta-2microglobulin, and ovalbumin-derived peptide.
1FZO 2001-03-28 1.8 MHC CLASS I NATURAL MUTANT H-2KBM8 HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND SENDAI VIRUS NUCLEOPROTEIN
5EFI 2016-03-30 1.8 Crystal structure of mouse CD1d in complex with the p99p lipopeptide
5FKP 2016-03-30 1.8 Crystal structure of the mouse CD1d in complex with the p99 peptide
2FIK 2006-03-21 1.8 Structure of a microbial glycosphingolipid bound to mouse CD1d
5TW5 2017-09-20 1.85 Structure of mouse CD1d with bound glycosphingolipid JJ112
3ILP 2010-01-26 1.85 Structure of mCD1d with bound glycolipid BbGL-2f from Borrelia burgdorferi
6G9Q 2019-04-24 1.89 Ternary complex of P14 TCR with murine MHC class I H-2 Db in complex with self-antigen derived from dopamine monooxygenase.
2AKR 2005-12-06 1.9 Structural basis of sulfatide presentation by mouse CD1d
1U58 2005-07-19 1.9 Crystal structure of the murine cytomegalovirus MHC-I homolog m144
3GMR 2009-11-10 1.9 Structure of mouse CD1d in complex with C8Ph, different space group
5OQG 2018-04-11 1.9 Crystal structure of a single chain trimer composed of the MHC I heavy chain H-2Kb W167A, beta-2microglobulin, and and ovalbumin-derived peptide.
2CLZ 2006-06-14 1.9 Mhc Class I Natural Mutant H-2Kbm8 Heavy Chain Complexed With beta-2 Microglobulin and pBM1 peptide
1FZJ 2001-03-28 1.9 MHC CLASS I NATURAL MUTANT H-2KBM1 HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND VESICULAR STOMATITIS VIRUS NUCLEOPROTEIN
4L8D 2013-10-16 1.9 Crystal structure of the H2Db in complex with the NP-N5D peptide
2CLV 2006-06-14 1.9 MHC Class I Natural Mutant H-2Kbm8 Heavy Chain Complexed With beta-2 Microglobulin and pBM8 peptide
1RJY 2004-12-14 1.9 Mhc Class I Natural Mutant H-2Kbm8 Heavy Chain Complexed With beta-2 Microglobulin and Herpes Simplex Virus Glycoprotein B Peptide
3PWU 2011-08-24 1.9 An immmunodominant CTL epitope from rinderpest virus presented by cattle MHC class I molecule N*01801(BoLA-A11)
3VJ6 2012-03-14 1.9 Structure of the MHC class Ib molecule Qa-1b
1WBX 2005-01-19 1.9 CRYSTAL STRUCTURES OF MURINE MHC CLASS I H-2 Db AND Kb MOLECULES IN COMPLEX WITH CTL EPITOPES FROM INFLUENZA A VIRUS: IMPLICATIONS FOR TCR REPERTOIRE SELECTION AND IMMUNODOMINANCE
3CC5 2009-03-03 1.91 H-2Db complex with human gp100
6I8C 2019-10-02 1.92 Crystal structure of the murine beta-2-microglobulin
4MS8 2014-09-24 1.92 42F3 TCR pCPB9/H-2Ld Complex
6MJJ 2019-01-09 1.93 Crystal structure of the mCD1d/xxm (JJ290) /iNKTCR ternary complex
6C69 2019-01-30 1.94 Structure of glycolipid aGSA[12,6P] in complex with mouse CD1d
6CYW 2019-04-10 1.95 Structure of sphingomyelin in complex with mouse CD1d
5M00 2017-12-20 1.95 Crystal structure of murine P14 TCR complex with H-2Db and Y4A, modified gp33 peptide from LCMV
2Q7Y 2008-04-01 1.95 Structure of the endogenous iNKT cell ligand iGb3 bound to mCD1d
3ERY 2008-11-25 1.95 Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors
5M01 2017-10-25 1.95 Crystal structure of murine P14 TCR/ H-2Db complex with PA, modified gp33 peptide from LCMV
5T7G 2017-10-11 1.96 Crystal Structure of Murine MHC-I H-2Dd in complex with Murine Beta2-Microglobulin and a Variant of Peptide (PT9) of HIV gp120 MN Isolate (IGPGRAFYT)
3WS6 2014-03-26 1.98 Crystal Structure of H-2D in complex with a mimotopic peptide
5E8O 2016-02-03 1.98 The structure of the TEIPP associated altered peptide ligand Trh4-p2ABU in complex with H-2D(b)
1S7S 2004-05-04 1.99 Crystal structures of the murine class I major histocompatibility complex H-2Kb in complex with LCMV-derived gp33 index peptide and three of its escape variants
1S7Q 2004-05-04 1.99 Crystal structures of the murine class I major histocompatibility complex H-2Kb in complex with LCMV-derived gp33 index peptide and three of its escape variants
6E1I 2019-07-17 1.99 HLA-A*0201 single chain trimer with murine H2K alpha 3 domain and HPV.16 E7 peptide YMLDLQPET
4HV8 2013-02-27 2.0 Crystal Structure of H2Db-H155A-NPM6I
4HUU 2013-02-27 2.0 Crystal Structure of H2Db-NPM6I
5E8P 2016-02-03 2.0 The structure of the TEIPP associated altered peptide ligand Trh4-p5NLE in complex with H-2D(b)
1WBZ 2005-01-19 2.0 CRYSTAL STRUCTURES OF MURINE MHC CLASS I H-2 Db AND Kb MOLECULES IN COMPLEX WITH CTL EPITOPES FROM INFLUENZA A VIRUS: IMPLICATIONS FOR TCR REPERTOIRE SELECTION AND IMMUNODOMINANCE
2QRS 2007-11-06 2.0 Crystal Structure of a single chain trimer composed of the MHC I heavy chain H-2Kb Y84A, beta-2microglobulin, and ovalbumin-derived peptide.
3QUL 2012-03-21 2.0 Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 altered peptide ligand (Y4S)
1T0M 2004-11-23 2.0 Conformational switch in polymorphic H-2K molecules containing an HSV peptide
6C6H 2019-01-30 2.0 Structure of glycolipid aGSA[8,P5m] in complex with mouse CD1d
1JUF 2002-03-20 2.0 Structure of Minor Histocompatibility Antigen peptide, H13b, complexed to H2-Db
6MP0 2018-11-07 2.0 Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with the TRP1-M9 peptide
4PGE 2015-01-07 2.0 MHC Class I in complex with modified Sendai virus nucleoprotein peptide FAPGNYPAW
4PV9 2014-04-23 2.0 Crystal Structure of H2Kb-Q600V complex
3P9M 2011-10-19 2.0 Crystal Structure of H2-Kb in complex with a mutant of the chicken ovalbumin epitope OVA-G4
3P9L 2011-10-19 2.0 Crystal Structure of H2-Kb in complex with the chicken ovalbumin epitope OVA
2QRI 2007-11-06 2.0 Crystal structure of a single chain trimer composed of the MHC I heavy chain H-2Kb WT, beta-2microglobulin, and ovalbumin-derived peptide.
6CW9 2019-04-03 2.0 Structure of alpha-GC[8,16P] bound by CD1d and in complex with the Va14Vb8.2 TCR
3ROO 2012-04-04 2.0 Murine class I major histocompatibility complex H-2Kb in complex with immunodominant LCMV-derived gp34-41 peptide
6MJ4 2019-01-09 2.0 Crystal structure of MCD1D/INKTCR TERNARY COMPLEX bound to glycolipid (XXW)
3FON 2010-01-12 2.03 Crystal structure of the Class I MHC Molecule H-2Kwm7 with a Single Self Peptide VNDIFEAI
6CXE 2019-04-10 2.05 Structure of alpha-GSA[26,6P] bound by CD1d and in complex with the Va14Vb8.2 TCR
3ILQ 2010-01-26 2.05 Structure of mCD1d with bound glycolipid BbGL-2c from Borrelia burgdorferi
5OQH 2018-04-18 2.05 Crystal Structure of a disulfide trapped single chain trimer composed of the MHC I heavy chain H-2Kb Y84C K66A mutant, beta-2microglobulin, and ovalbumin-derived peptide
5VCL 2017-10-25 2.05 Structure of the Qdm peptide bound to Qa-1a
6MIV 2019-01-09 2.05 Crystal structure of the mCD1d/xxq (JJ300)/iNKTCR ternary complex
6C6C 2019-01-30 2.08 Structure of glycolipid aGSA[20,6P] in complex with mouse CD1d
1RK1 2004-12-14 2.1 Mhc Class I Natural H-2Kb Heavy Chain Complexed With beta-2 Microglobulin and Herpes Simplex Virus Mutant Glycoprotein B Peptide
1MHC 1996-01-29 2.1 MODEL OF MHC CLASS I H2-M3 WITH NONAPEPTIDE FROM RAT ND1 REFINED AT 2.3 ANGSTROMS RESOLUTION
3FOM 2010-01-12 2.1 Crystal structure of the Class I MHC Molecule H-2Kwm7 with a Single Self Peptide IQQSIERL
1OSZ 1999-01-13 2.1 MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND AN (L4V) MUTANT OF THE VESICULAR STOMATITIS VIRUS NUCLEOPROTEIN
1PQZ 2004-07-06 2.1 MURINE CYTOMEGALOVIRUS IMMUNOMODULATORY PROTEIN M144
3E6H 2009-08-18 2.1 MHC CLASS I H-2Dd heavy chain complexed with Beta-2 Microglobulin and a variant peptide, PI10, from the human immunodeficiency virus (BaL) envelope glycoprotein 120
2ZOK 2008-06-10 2.1 Crystal structure of H-2Db in complex with JHMV epitope S510
1NEZ 2003-04-08 2.1 The Crystal Structure of a TL/CD8aa Complex at 2.1A resolution:Implications for Memory T cell Generation, Co-receptor Preference and Affinity
3TBV 2012-08-08 2.1 CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX WITH THE LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (A2G,V3P,Y4A)
5WLG 2017-11-15 2.1 Crystal Structure of H-2Db with the GAP501 peptide (SQL)
4HS3 2014-05-07 2.1 Crystal structure of H-2Kb with a disulfide stabilized F pocket in complex with the LCMV derived peptide GP34
5IVX 2017-03-29 2.1 Crystal Structure of B4.2.3 T-Cell Receptor and H2-Dd P18-I10 Complex
3TJH 2011-12-07 2.12 42F3-p3A1/H2-Ld complex
6GB7 2019-03-06 2.15 Structure of H-2Db with scoop loop from tapasin
6A97 2018-12-05 2.15 Crystal structure of MHC-like MILL2
1LEK 2002-06-26 2.15 Crystal Structure of H-2Kbm3 bound to dEV8
3TBW 2012-08-08 2.15 CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX WITH THE LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (A2G, V3P, Y4S)
6OJP 2019-08-21 2.17 Structure of glycolipid alpha-GSA[8,6P] in complex with mouse CD1d
6C6E 2019-01-30 2.18 Structure of glycolipid aGSA[26,6P] in complex with mouse CD1d
1JPF 2001-10-24 2.18 Crystal Structure Of The LCMV Peptidic Epitope Gp276 In Complex With The Murine Class I Mhc Molecule H-2Db
1YN7 2005-06-28 2.2 Crystal structure of a mouse MHC class I protein, H2-Db, in complex with a mutated peptide (R7A) of the influenza A acid polymerase
1JPG 2001-10-24 2.2 Crystal Structure Of The LCMV Peptidic Epitope Np396 In Complex With The Murine Class I Mhc Molecule H-2Db
4ZUU 2016-04-06 2.2 Crystal structure of Equine MHC I(Eqca-N*00602) in complexed with equine infectious anaemia virus (EIAV) derived peptide Gag-CF9
1S7U 2004-05-04 2.2 Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 index peptide and three of its escape variants
5WLI 2017-11-15 2.2 Crystal Structure of H-2Db with the GAP501 peptide (SQL)
3RUG 2011-08-03 2.2 Crystal structure of Valpha10-Vbeta8.1 NKT TCR in complex with CD1d-alphaglucosylceramide (C20:2)
4L8B 2013-10-16 2.2 Crystal structure of the H2Db in complex with the NP-N5H peptide
1S7V 2004-05-04 2.2 Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 index peptide and three of its escape variants
3PAB 2011-10-19 2.2 Crystal Structure of H2-Kb in complex with a mutant of the chicken ovalbumin epitope OVA-E1
1YN6 2005-06-28 2.2 Crystal structure of a mouse MHC class I protein, H2-Db, in complex with a peptide from the influenza A acid polymerase
4HUX 2013-02-27 2.2 Crystal Structure of H2Db-H155A-NP
1Z5L 2005-07-19 2.2 Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D
1KBG 1999-02-09 2.2 MHC Class I H-2KB Presented Glycopeptide RGY8-6H-GAL2
6CWE 2019-04-03 2.2 Structure of alpha-GSA[8,6P] bound by CD1d and in complex with the Va14Vb8.2 TCR
1INQ 2002-03-20 2.2 Structure of Minor Histocompatibility Antigen peptide, H13a, complexed to H2-Db
6MP1 2018-11-07 2.21 Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with the mutant TRP1-K8 peptide
4MX7 2014-10-01 2.24 Structure of mouse CD1d in complex with dioleoyl-phosphatidic acid
5E8N 2016-02-03 2.25 The structure of the TEIPP associated Trh4 peptide in complex with H-2D(b)
3QUY 2011-06-29 2.25 Structure of the mouse CD1d-BnNH-GSL-1'-iNKT TCR complex
5OQF 2018-04-11 2.27 Crystal structure of a single chain trimer composed of the MHC 1 heavy chain H2-Kb WT, beta-2microglobulin, and ovalbumin derived peptide
3MA7 2011-03-16 2.29 Crystal structure of Cardiolipin bound to mouse CD1D
3P4O 2011-10-12 2.3 Crystal Structure of H2-Kb in complex with the mutant NP205-LCMV-V3A epitope YTAKYPNL, an 8-mer modified peptide from the LCMV
6GB5 2019-03-06 2.3 Structure of H-2Db with truncated SEV peptide and GL
6MJI 2019-01-09 2.3 Crystal structure of the mCD1d/xxs (JJ304) /iNKTCR ternary complex
1WBY 2005-01-19 2.3 CRYSTAL STRUCTURES OF MURINE MHC CLASS I H-2 Db AND Kb MOLECULES IN COMPLEX WITH CTL EPITOPES FROM INFLUENZA A VIRUS: IMPLICATIONS FOR TCR REPERTOIRE SELECTION AND IMMUNODOMINANCE
4PGC 2015-01-07 2.3 MHC Class I in complex with modified Sendai virus nucleoprotein peptide FAPGN(3,5-diiodotyrosine)PAL
3CH1 2009-03-31 2.3 Crystal structure of H-2Db in complex with chimeric gp100
6BMH 2018-01-31 2.3 Crystal structure of MHC-I like protein
4ZUV 2016-04-06 2.3 Crystal structure of Equine MHC I(Eqca-N*00602) in complexed with equine infectious anaemia virus (EIAV) derived peptide Env-RW12
3QI9 2012-02-15 2.3 Crystal structure of mouse CD1d-alpha-phosphotidylinositol with mouse Valpha14-Vbeta6 2A3-D NKT TCR
1NAN 2003-03-11 2.3 MCH CLASS I H-2KB MOLECULE COMPLEXED WITH PBM1 PEPTIDE
3QUZ 2011-06-29 2.3 Structure of the mouse CD1d-NU-alpha-GalCer-iNKT TCR complex
1K8D 2001-12-19 2.3 crystal structure of the non-classical MHC class Ib Qa-2 complexed with a self peptide
1KJ3 2002-03-27 2.3 Mhc Class I H-2Kb molecule complexed with pKB1 peptide
5J6H 2016-07-13 2.3 Recognition of the MHC class Ib molecule H2-Q10 by the natural killer cell receptor Ly49C
3TBT 2012-08-08 2.3 CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX WITH THE LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (V3P, Y4S)
2VAA 1996-06-20 2.3 MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND VESICULAR STOMATITIS VIRUS NUCLEOPROTEIN
1QO3 2000-01-02 2.3 Complex between NK cell receptor Ly49A and its MHC class I ligand H-2Dd
1S7T 2004-05-04 2.3 Crystal structures of the murine class I major histocompatibility complex H-2Kb in complex with LCMV-derived gp33 index peptide and three of its escape variants
4PV8 2014-04-23 2.31 Crystal Structure of H2Kb-Q600F complex
3WS3 2014-03-26 2.34 Crystal Structure of H-2D in complex with an insulin derived peptide
2OI9 2007-04-24 2.35 Structure of the 2C/Ld/QL9 allogeneic complex
5KD7 2017-10-11 2.35 Crystal Structure of Murine MHC-I H-2Dd in complex with Murine Beta2-Microglobulin and a Variant of Peptide (PV9) of HIV gp120 MN Isolate (IGPGRAFYV)
6MJA 2019-01-09 2.35 Crystal structure of the mCD1d/xxo (JJ294) /iNKTCR ternary complex
6CX9 2019-04-10 2.36 Structure of alpha-GSA[16,6P] bound by CD1d and in complex with the Va14Vb8.2 TCR
1BII 1998-10-14 2.4 THE CRYSTAL STRUCTURE OF H-2DD MHC CLASS I IN COMPLEX WITH THE HIV-1 DERIVED PEPTIDE P18-110
5JWE 2017-05-24 2.4 Crystal structure of H-2Db in complex with the LCMV-derived GP92-101 peptide
6CX5 2019-04-10 2.4 Structure of alpha-GSA[8,8P] bound by CD1d and in complex with the Va14Vb8.2 TCR
1LD9 1998-05-06 2.4 THE THREE-DIMENSIONAL STRUCTURE OF AN H-2LD PEPTIDE COMPLEX EXPLAINS THE UNIQUE INTERACTION OF LD WITH BETA2M AND PEPTIDE
6H6H 2019-08-14 2.4 Crystal structures of the murine class I major histocompatibility complex H-2Dbm13 in complex with adenovirus-derived peptide Ad10
1MWA 2002-11-27 2.4 2C/H-2KBM3/DEV8 ALLOGENEIC COMPLEX
6H6D 2019-08-14 2.4 Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with adenovirus-derived peptide Ad10
1HOC 1994-04-30 2.4 THE THREE-DIMENSIONAL STRUCTURE OF H-2DB AT 2.4 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ANTIGEN-DETERMINANT SELECTION
5OQI 2018-04-11 2.4 Crystal Structure of a disulfide trapped single chain trimer composed of the MHC I heavy chain H-2Kb Y84C E63A mutant, beta-2microglobulin, and ovalbumin-derived peptide
4PG9 2015-01-07 2.4 MHC Class I in complex with Sendai virus nucleoprotein peptide FAPGNYPAL
5MZM 2018-03-21 2.4 Structure of H-2Db in complex with TEIPP APL Trh4 p3P
1S7W 2004-05-04 2.4 Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 index peptide and three of its escape variants
3QUK 2012-03-21 2.41 Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 altered peptide ligand (Y4A)
1S7X 2004-05-04 2.41 Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 index peptide and three of its escape variants
3E6F 2009-08-18 2.41 MHC CLASS I H-2Dd Heavy chain complexed with Beta-2 Microglobulin and a variant peptide, PA9, from the Human immunodeficiency virus (BaL) envelope glycoprotein 120
6BMK 2018-01-31 2.43 Crystal structure of MHC-I like protein
6OOR 2019-07-17 2.45 Structure of 1B1 bound to mouse CD1d
6C6A 2019-01-30 2.45 Structure of glycolipid aGSA[16,6P] in complex with mouse CD1d
6C5M 2019-01-30 2.45 Structure of glycolipid aGSA[8,9] in complex with mouse CD1d
6MJ6 2019-01-09 2.45 Crystal structure of the mCD1d/xxx (JJ166) /iNKTCR ternary complex
3TBS 2012-08-08 2.49 CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX THE WITH LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (V3P,Y4A)
3TBY 2012-08-08 2.5 CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX WITH THE LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (V3P, Y4F)
3CPL 2008-11-18 2.5 Crystal Structure of H-2Db in complex with a variant M6A of the NP366 peptide from influenza A virus
1VAD 1996-06-20 2.5 MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND YEAST ALPHA-GLUCOSIDASE
6CXF 2019-04-10 2.5 Structure of alpha-GSA[26,P5p] bound by CD1d and in complex with the Va14Vb8.2 TCR
2E7L 2007-04-24 2.5 Structure of a high-affinity mutant of the 2C TCR in complex with Ld/QL9
1FO0 2000-10-02 2.5 MURINE ALLOREACTIVE SCFV TCR-PEPTIDE-MHC CLASS I MOLECULE COMPLEX
1VAC 1996-06-20 2.5 MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND CHICKEN OVALBUMIN
2VAB 1996-06-20 2.5 MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND SENDAI VIRUS NUCLEOPROTEIN
3FOL 2010-01-12 2.5 Crystal structure of the Class I MHC Molecule H-2Kwm7 with a Single Self Peptide VNDIFERI
4HUV 2013-02-27 2.5 Crystal Structure of H2Db-NPM6W
3P4N 2011-10-12 2.5 Crystal Structure of H2-Kb in complex with the NP205-PV epitope YTVKFPNM, an 8-mer peptide from PV
2MHA 1993-10-31 2.5 CRYSTAL STRUCTURE OF THE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I H-2KB MOLECULE CONTAINING A SINGLE VIRAL PEPTIDE: IMPLICATIONS FOR PEPTIDE BINDING AND T-CELL RECEPTOR RECOGNITION
1ZT1 2005-10-18 2.5 crystal structure of class I MHC H-2Kk in complex with an octapeptide
5JWD 2017-05-24 2.5 Crystal structure of H-2Db in complex with the LCMV-derived GP392-401 peptide
3P4M 2011-10-12 2.5 Crystal Structure of H2-Kb in complex with the NP205-LCMV epitope YTVKYPNL, an 8-mer peptide from the LCMV
3SCM 2011-10-05 2.5 Crystal structure of autoreactive-Valpha14-Vbeta6 NKT TCR in complex with CD1d-isoglobotrihexosylceramide
3AU1 2011-10-12 2.5 Crystal structure of mouse CD1d in complex with ganglioside GD3
2CII 2006-03-29 2.55 The crystal structure of H-2Db complexed with a partial peptide epitope suggests an MHC Class I assembly-intermediate
4NSK 2014-01-01 2.6 CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX WITH LCMV-DERIVED GP33 ALTERED PEPTIDE ligand V3P
1FFP 2002-12-11 2.6 CRYSTAL STRUCTURE OF MURINE CLASS I H-2DB COMPLEXED WITH PEPTIDE GP33 (C9M/K1S)
6BNL 2018-04-04 2.6 Crystal structure of TCR-MHC-like molecule
4MXQ 2015-08-19 2.6 42F3 TCR pCPC5/H-2Ld Complex
1RJZ 2004-12-14 2.6 Mhc Class I Natural Mutant H-2Kbm8 Heavy Chain Complexed With beta-2 Microglobulin and Herpies Simplex Virus Mutant Glycoprotein B Peptide
4ZUT 2016-04-06 2.6 Crystal structure of Equine MHC I(Eqca-N*00602) in complexed with equine infectious anaemia virus (EIAV) derived peptide Gag-GW12
3FTG 2009-12-29 2.6 Crystal Structure of H2Db in complex with NP366-N3A variant peptide from influenza
3BUY 2008-03-25 2.6 MHC-I in complex with peptide
4Y16 2015-06-03 2.6 Crystal structure of the mCD1d/NC-aGC/iNKTCR ternary complex
2FWO 2006-02-21 2.6 MHC Class I H-2Kd heavy chain in complex with beta-2microglobulin and peptide derived from influenza nucleoprotein
3CCH 2009-03-10 2.6 H-2Db complex with murine gp100
4MQ7 2013-12-18 2.6 Structure of human CD1d-sulfatide
3DMM 2009-07-14 2.6 Crystal structure of the CD8 alpha beta/H-2Dd complex
6CX7 2019-04-10 2.6 Structure of alpha-GSA[12,6P] bound by CD1d and in complex with the Va14Vb8.2 TCR
4ZUS 2016-04-06 2.6 Crystal structure of Equine MHC I(Eqca-N*00602) in complexed with equine infectious anaemia virus (EIAV) derived peptide REV-QW11
3ROL 2012-04-04 2.6 Murine class I major histocompatibility complex H-2Kb in complex with post-translationally modified LCMV-derived gp34-41 peptide, comprising a nitrotyrosine at position 3
4ZUW 2016-04-06 2.6 Crystal structure of Equine MHC I(Eqca-N*00601) in complexed with equine infectious anaemia virus (EIAV) derived peptide Gag-GW12
1RK0 2004-12-14 2.61 Mhc Class I H-2Kb Heavy Chain Complexed With beta-2 Microglobulin and Herpes Simplex Virus Glycoprotein B peptide
2GAZ 2006-09-26 2.61 Mycobacterial lipoglycan presentation by CD1d
5WET 2017-10-18 2.64 Crystal Structure of H2-Dd with disulfide-linked 6mer peptide
5SWZ 2016-10-05 2.65 Crystal Structure of NP1-B17 TCR-H2Db-NP complex
2VE6 2008-01-22 2.65 Crystal structure of a Murine MHC class I H2-Db molecule in complex with a photocleavable peptide
6CXA 2019-04-10 2.65 Structure of alpha-GSA[20,6P] bound by CD1d and in complex with the Va14Vb8.2 TCR
1QLF 1999-09-01 2.65 MHC CLASS I H-2DB COMPLEXED WITH GLYCOPEPTIDE K3G
1FFO 2002-12-11 2.65 CRYSTAL STRUCTURE OF MURINE CLASS I H-2DB COMPLEXED WITH SYNTHETIC PEPTIDE GP33 (C9M/K1A)
1CD1 1997-10-15 2.67 CD1(MOUSE) ANTIGEN PRESENTING MOLECULE
1NAM 2003-03-11 2.7 MURINE ALLOREACTIVE SCFV TCR-PEPTIDE-MHC CLASS I MOLECULE COMPLEX
1HYR 2001-05-23 2.7 CRYSTAL STRUCTURE OF HUMAN MICA IN COMPLEX WITH NATURAL KILLER CELL RECEPTOR NKG2D
1FFN 2002-12-11 2.7 CRYSTAL STRUCTURE OF MURINE CLASS I H-2DB COMPLEXED WITH PEPTIDE GP33(C9M)
2FO4 2006-11-14 2.7 Enhanced MHC class I binding and immune responses through anchor modification of the non-canonical tumor associated MUC1-8 peptide
4PGD 2015-01-07 2.7 MHC Class I in complex with modified Sendai virus nucleoprotein peptide FAPGNYPAF
6G9R 2019-04-24 2.7 Murine class I major histocompatibility complex H-2 Db in complex with self-antigen derived from dopamine monooxygenase.
1ZHB 2005-06-14 2.7 Crystal Structure Of The Murine Class I Major Histocompatibility Complex Of H-2Db, B2-Microglobulin, and a 9-Residue Peptide Derived from rat dopamine beta-monooxigenase
3TA3 2011-11-23 2.7 Structure of the mouse CD1d-Glc-DAG-s2-iNKT TCR complex
3ARB 2011-03-30 2.7 Ternary crystal structure of the NKT TCR-CD1d-alpha-galactosylceramide analogue-OCH
2ZOL 2008-06-10 2.7 Crystal structure of H-2Db in complex with the W513S variant of JHMV epitope S510
2F74 2006-02-14 2.7 Murine MHC class I H-2Db in complex with human b2-microglobulin and LCMV-derived immunodminant peptide gp33
3L3H 2010-03-16 2.7 X-ray crystal structure of the F6A mutant of influenza A acid polymerase epitope PA224 bound to murine H2-Db MHC
1KJ2 2002-03-27 2.71 Murine Alloreactive ScFv TCR-Peptide-MHC Class I Molecule Complex
5WES 2017-10-18 2.71 Crystal Structure H2-Dd with disulfide-linked 5mer peptide
3O8X 2010-09-29 2.74 Recognition of Glycolipid Antigen by iNKT Cell TCR
3TFK 2011-12-07 2.75 42F3-p4B10/H2-Ld
1FG2 2000-10-04 2.75 CRYSTAL STRUCTURE OF THE LCMV PEPTIDIC EPITOPE GP33 IN COMPLEX WITH THE MURINE CLASS I MHC MOLECULE H-2DB
6MIY 2019-01-09 2.75 Crystal structure of the mCD1d/xxa (JJ239)/iNKTCR ternary complex
3TF7 2011-12-07 2.75 42F3 QL9/H2-Ld complex
3O9W 2010-09-29 2.8 Recognition of a Glycolipid Antigen by the iNKT Cell TCR
3RTQ 2012-02-22 2.8 Structure of the mouse CD1d-HS44-iNKT TCR complex
1BZ9 1999-05-24 2.8 CRYSTAL STRUCTURE OF MURINE CLASS I MHC H2-DB COMPLEXED WITH A SYNTHETIC PEPTIDE P1027
4IHO 2013-09-11 2.8 Crystal structure of H-2Db Y159F in complex with chimeric gp100
4L8C 2013-10-16 2.8 Crystal structure of the H2Db in complex with the NP-N3D peptide
4PGB 2015-01-07 2.8 MHC Class I in complex with modified Sendai virus nucleoprotein peptide FAPGNWPAL
2ZSW 2008-11-04 2.8 Crystal structure of H-2Kb in complex with the Q600Y variant of JHMV epitope S598
3HE7 2009-07-28 2.8 Crystal structure of mouse CD1d-alpha-galactosylceramide with mouse Valpha14-Vbeta7 NKT TCR
3SDA 2011-10-05 2.8 Crystal structure of autoreactive-Valpha14-Vbeta6 NKT TCR in complex with CD1d-beta-galactosylceramide
1G6R 2000-11-15 2.8 A FUNCTIONAL HOT SPOT FOR ANTIGEN RECOGNITION IN A SUPERAGONIST TCR/MHC COMPLEX
3ARE 2011-03-30 2.8 Ternary crystal structure of the mouse NKT TCR-CD1d-4'deoxy-alpha-galactosylceramide
3TVM 2012-02-01 2.8 Structure of the mouse CD1d-SMC124-iNKT TCR complex
4IRS 2013-09-04 2.8 Structure of the mouse CD1d-PyrC-alpha-GalCer-iNKT TCR complex
1BQH 1998-08-19 2.8 MURINE CD8AA ECTODOMAIN FRAGMENT IN COMPLEX WITH H-2KB/VSV8
3RZC 2011-08-24 2.8 Structure of the self-antigen iGb3 bound to mouse CD1d and in complex with the iNKT TCR
4PG2 2014-09-10 2.8 The crystal structure of H-2Db with a S-glutathionylated peptide
1ZHN 2005-07-19 2.8 Crystal Structure of mouse CD1d bound to the self ligand phosphatidylcholine
4ZAK 2015-07-01 2.82 Crystal structure of the mCD1d/DB06-1/iNKTCR ternary complex
5TIL 2017-11-01 2.83 Murine class I major histocompatibility complex H-2 Db in complex with LCMV-derived GP33 altered peptide V3P and T-cell receptor P14
6CW6 2019-04-03 2.85 Structure of alpha-GC[8,18] bound by CD1d and in complex with the Va14Vb8.2 TCR
6CWB 2019-04-03 2.85 Structure of alpha-GSA[8,4P] bound by CD1d and in complex with the Va14Vb8.2 TCR
1N5A 2003-01-07 2.85 Crystal structure of the Murine class I Major Histocompatibility Complex of H-2DB, B2-Microglobulin, and A 9-Residue immunodominant peptide epitope gp33 derived from LCMV
5SWS 2016-10-05 2.86 Crystal Structure of NP2-B17 TCR-H2Db-NP complex
4N0C 2015-08-19 2.9 42F3 TCR pCPE3/H-2Ld complex
3HE6 2009-07-28 2.9 Crystal structure of mouse CD1d-alpha-galactosylceramide with mouse Valpha14-Vbeta8.2 NKT TCR
2OL3 2007-04-03 2.9 crystal structure of BM3.3 ScFV TCR in complex with PBM8-H-2KBM8 MHC class I molecule
3RGV 2011-07-20 2.9 A single TCR bound to MHCI and MHC II reveals switchable TCR conformers
3C8K 2008-04-15 2.9 The crystal structure of Ly49C bound to H-2Kb
4Y4K 2015-05-27 2.9 Crystal structure of the mCD1d/EF77/iNKTCR ternary complex
3CVH 2008-09-23 2.9 How TCR-like antibody recognizes MHC-bound peptide
1P4L 2003-11-11 2.9 Crystal structure of NK receptor Ly49C mutant with its MHC class I ligand H-2Kb
1CE6 1999-03-26 2.9 MHC CLASS I H-2DB COMPLEXED WITH A SENDAI VIRUS NUCLEOPROTEIN PEPTIDE
3ARF 2011-03-30 2.9 Ternary crystal structure of the mouse NKT TCR-CD1d-C20:2
4NHU 2015-05-06 2.9 The M33 TCR p3M33l/H-2 Ld Complex
3QUX 2011-06-29 2.91 Structure of the mouse CD1d-alpha-C-GalCer-iNKT TCR complex
1S7R 2004-05-04 2.95 Crystal structures of the murine class I major histocompatibility complex H-2Kb in complex with LCMV-derived gp33 index peptide and three of its escape variants
3E3Q 2008-11-04 2.95 Structure of the 3alpham13 high-affinity mutant of the 2C TCR in complex with Ld/QL9
1N59 2003-01-07 2.95 Crystal structure of the Murine class I Major Histocompatibility Complex of H-2KB, B2-Microglobulin, and A 9-Residue immunodominant peptide epitope gp33 derived from LCMV
3ARG 2011-03-30 3.0 Ternary crystal structure of the mouse NKT TCR-CD1d-alpha-glucosylceramide(C20:2)
4APQ 2013-04-24 3.0 Crystal structure of autoreactive-Valpha14-Vbeta6 NKT TCR in complex with CD1d-sulfatide
1ZT7 2005-10-18 3.0 crystal structure of class I MHC H-2Kk in complex with a nonapeptide
3SDD 2011-10-05 3.0 Crystal structure of autoreactive-Valpha14-Vbeta6 NKT TCR in complex with CD1d-beta-lactosylceramide
2CKB 1998-04-29 3.0 STRUCTURE OF THE 2C/KB/DEV8 COMPLEX
1B3J 1999-07-09 3.0 STRUCTURE OF THE MHC CLASS I HOMOLOG MIC-A, A GAMMADELTA T CELL LIGAND
1N3N 2003-05-27 3.0 Crystal structure of a mycobacterial hsp60 epitope with the murine class I MHC molecule H-2Db
6MJQ 2019-01-09 3.0 Crystal structure of the mCD1d/xxp (JJ295) /iNKTCR ternary complex
4IRJ 2013-08-28 3.0 Structure of the mouse CD1d-4ClPhC-alpha-GalCer-iNKT TCR complex
6MSS 2019-10-02 3.0 Diversity in the type II Natural Killer T cell receptor repertoire and antigen specificity leads to differing CD1d docking strategies
4MNG 2013-12-18 3.01 Structure of the DP10.7 TCR with CD1d-sulfatide
3ARD 2011-03-30 3.01 Ternary crystal structure of the mouse NKT TCR-CD1d-3'deoxy-alpha-galactosylceramide
5KD4 2017-10-11 3.05 Crystal Structure of Murine MHC-I H-2Dd in complex with Murine Beta2-Microglobulin and a Variant of Peptide (PVI10) of HIV gp120 MN Isolate (IGPGRAFYVI)
4Y2D 2015-05-27 3.05 Crystal structure of the mCD1d/7DW8-5/iNKTCR ternary complex
4N5E 2015-08-19 3.06 42F3 TCR pCPA12/H-2Ld complex
4MVB 2015-08-19 3.09 42F3 pCPB7/H-2Ld Complex
1DDH 1999-01-13 3.1 MHC CLASS I H-2DD HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND AN IMMUNODOMINANT PEPTIDE P18-I10 FROM THE HUMAN IMMUNODEFICIENCY VIRUS ENVELOPE GLYCOPROTEIN 120
4EI5 2012-07-25 3.1 Crystal Structure of XV19 TCR in complex with CD1d-sulfatide C24:1
4Y4H 2015-05-27 3.1 Crystal structure of the mCD1d/GCK152/iNKTCR ternary complex
3SDC 2011-10-05 3.1 Crystal structure of autoreactive-Valpha14-Vbeta6 NKT TCR in complex with CD1d-globotrihexosylceramide
3UBX 2011-11-16 3.1 Crystal structure of the mouse CD1d-C20:2-aGalCer-L363 mAb Fab complex
3TO4 2011-12-14 3.1 Structure of mouse Valpha14Vbeta2-mouseCD1d-alpha-Galactosylceramide
1LDP 1998-06-17 3.1 CRYSTAL STRUCTURE OF MURINE MHC CLASS I H-2LD WITH A MIXTURE OF BOUND PEPTIDES
3TPU 2011-12-07 3.1 42F3 p5E8/H2-Ld complex
5VCJ 2018-04-04 3.16 Structure of alpha-galactosylphytosphingosine bound by CD1d and in complex with the Va14Vb8.2 TCR
4HUW 2013-02-27 3.16 Crystal Structure of H2Db-NPM6T
4Y4F 2015-05-27 3.19 Crystal structure of the mCD1d/GCK127/iNKTCR ternary complex
3PQY 2011-05-18 3.19 Crystal Structure of 6218 TCR in complex with the H2Db-PA224
3TN0 2011-12-14 3.2 Structure of mouse Va14Vb8.2NKT TCR-mouse CD1d-a-C-Galactosylceramide complex
6BNK 2018-04-04 3.2 Crystal structure of TCR-MHC-like molecule
5TJE 2017-11-01 3.2 Murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 and T cell receptor P14
1P1Z 2003-11-11 3.26 X-RAY CRYSTAL STRUCTURE OF THE LECTIN-LIKE NATURAL KILLER CELL RECEPTOR LY-49C BOUND TO ITS MHC CLASS I LIGAND H-2Kb
5J6G 2016-07-13 3.3 Recognition of the MHC class Ib molecule H2-Q10 by the natural killer cell receptor Ly49C
5OPI 2017-10-18 3.3 Crystal structure of the TAPBPR-MHC I peptide editing complex
4ELM 2012-07-25 3.48 Crystal structure of the mouse CD1d-lysosulfatide-Hy19.3 TCR complex
3E2H 2008-11-04 3.8 Structure of the m67 high-affinity mutant of the 2C TCR in complex with Ld/QL9

Relevant UniProtKB Entries

Percent Identity Matching Chains Protein Accession Entry Name
100.0 A H-2 class I histocompatibility antigen, D-B alpha chain P01899 HA11_MOUSE
93.8 A H-2 class I histocompatibility antigen, D-B alpha chain P01897 HA1L_MOUSE
95.4 A H-2 class I histocompatibility antigen, D-B alpha chain P01896 HA1Z_MOUSE
99.0 B H-2 class I histocompatibility antigen, D-B alpha chain P01887 B2MG_MOUSE
100.0 Minor histocompatibility antigen H13 Q9D8V0 HM13_MOUSE
95.8 Minor histocompatibility antigen H13 Q8TCT9 HM13_HUMAN
100.0 MHC class I polypeptide-related sequence A Q29983 MICA_HUMAN