Stabilization of the ribosomal protein S6 by trehalose is counterbalanced by the formation of a putative off-pathway species.


Abstract

The effect of trehalose on folding and stability of the small ribosomal protein S6 was studied. Non-disruptive point mutations distributed along the protein structure were analyzed to characterize the stabilizing effect of trehalose and map the folding pathway of S6. On average, the stability of the wild-type and S6 mutants increases by 3 kcal/mol M trehalose. Despite the non-specific thermodynamic stabilization mechanism, trehalose particularly stabilizes the less destabilized mutants. Folding/unfolding kinetics shows clearly that trehalose induces the collapse of the unfolded state to an off-pathway intermediate with non-native diffuse contacts. This state is similar to the collapsed state induced by high concentrations of stabilizing salts, as previously reported. Although it leads to the accumulation of this off-pathway intermediate, trehalose does not change the compactness of the transition state ensemble. Furthermore, the productive folding pathway of S6 is not affected by trehalose as shown by a Phi-value analysis. The unfolded state ensemble of S6 should be more compact in the presence of trehalose and therefore destabilized due to decreased conformational entropy. Increased compaction of the unfolded state ensemble might also occur for more stable mutants of S6, thus explaining the synergistic effect of trehalose and point mutations on protein stabilization. Study holds ProTherm entries: 19619, 19620, 19621, 19622, 19623, 19624, 19625, 19626, 19627, 19629, 19630, 19631, 19632, 19633, 19634, 19635, 19636, 19637, 19638, 19639, 19640, 19641, 19642, 19643, 19644, 19645, 19646, 19647, 19648, 19649, 19650, 19651, 19652, 19653, 19654, 19655, 19656, 19657, 19658, 19659, 19660, 19661, 19662, 19663, 19664, 19665, 19666, 19667, 19668, 19669, 19670, 19671, 19672, 19673, 19674, 19675, 19676, 19677, 19678, 19679, 19680, 19681, 19682, 19683, 19684, 19685, 19686 Extra Details: ribosomal protein S6; trehalose; protein folding and stability; off-pathway intermediate

Submission Details

ID: AZTuVvTv

Submitter: Connie Wang

Submission Date: April 24, 2018, 8:51 p.m.

Version: 1

Publication Details
Chen L;Cabrita GJ;Otzen DE;Melo EP,J. Mol. Biol. (2005) Stabilization of the ribosomal protein S6 by trehalose is counterbalanced by the formation of a putative off-pathway species. PMID:16002092
Additional Information

Structure view and single mutant data analysis

Study data

No weblogo for data of varying length.
Colors: D E R H K S T N Q A V I L M F Y W C G P
 

Data Distribution

Studies with similar sequences (approximate matches)

Correlation with other assays (exact sequence matches)


Relevant PDB Entries

Structure ID Release Date Resolution Structure Title
2KJW 2009-12-22 Solution structure and backbone dynamics of the permutant P54-55
2KJV 2009-12-22 Solution structure and backbone dynamics of the ribosomal protein S6wt
3ZZP 2011-11-23 0.96 Circular permutant of ribosomal protein S6, lacking edge strand beta- 2 of wild-type S6.
1CQM 2000-09-08 1.65 PROTEIN AGGREGATION AND ALZHEIMER'S DISEASE: CRYSTALLOGRAPHIC ANALYSIS OF THE PHENOMENON. ENGINEERED VERSION OF THE RIBOSOMAL PROTEIN S6 USED AS A STABLE SCAFFOLD TO STUDY OLIGOMERIZATION.
1LOU 1998-11-30 1.95 RIBOSOMAL PROTEIN S6
1EG0 2000-03-06 11.5 FITTING OF COMPONENTS WITH KNOWN STRUCTURE INTO AN 11.5 A CRYO-EM MAP OF THE E.COLI 70S RIBOSOME
1ML5 2003-01-14 14.0 Structure of the E. coli ribosomal termination complex with release factor 2
1RIS 1994-09-30 2.0 CRYSTAL STRUCTURE OF THE RIBOSOMAL PROTEIN S6 FROM THERMUS THERMOPHILUS
1CQN 2000-09-08 2.1 PROTEIN AGGREGATION AND ALZHEIMER'S DISEASE: CRYSTALLOGRAPHIC ANALYSIS OF THE PHENOMENON. ENGINEERED VERSION OF THE RIBOSOMAL PROTEIN S6 USED AS A STABLE SCAFFOLD TO STUDY OLIGOMERIZATION.
1QJH 2000-06-29 2.2 Protein Aggregation and Alzheimer's Disease: Crystallographic Analysis of the Phenomenon. Engineered version of the ribosomal protein S6 used as a stable scaffold to study oligomerization.
2BVZ 2005-10-26 2.2 Mutant of the Ribosomal Protein S6
4Y4O 2015-03-18 2.3 Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to protein Y (YfiA) at 2.3A resolution
2BXJ 2005-10-26 2.4 Double Mutant of the Ribosomal Protein S6
4W2F 2014-10-15 2.4 Crystal structure of the Thermus thermophilus 70S ribosome in complex with amicoumacin, mRNA and three deacylated tRNAs in the A, P and E sites
2VQE 2008-04-29 2.5 Modified uridines with C5-methylene substituents at the first position of the tRNA anticodon stabilize U-G wobble pairing during decoding
4Y4P 2015-03-18 2.5 Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to mRNA and A-, P- and E-site tRNAs at 2.5A resolution
4W2G 2014-10-15 2.55 Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (soaked), mRNA and three deacylated tRNAs in the A, P and E sites
1VY5 2014-08-20 2.55 Crystal structure of the Thermus thermophilus 70S ribosome in the post-catalysis state of peptide bond formation containing dipeptydil-tRNA in the A site and deacylated tRNA in the P site.
6CAE 2018-04-18 2.6 Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution
5J8B 2016-05-25 2.6 Crystal structure of Elongation Factor 4 (EF-4/LepA) in complex with GDPCP bound to the Thermus thermophilus 70S ribosome
6ND5 2019-03-20 2.6 Crystal structure of the Thermus thermophilus 70S ribosome in complex with chloramphenicol and bound to mRNA and A-, P-, and E-site tRNAs at 2.60A resolution
5DOY 2015-12-30 2.6 Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution
6CFL 2018-03-07 2.6 Crystal structure of the Thermus thermophilus 70S ribosome in complex with lysyl-CAM and bound to protein Y (YfiA) at 2.6A resolution
1VY4 2014-08-20 2.6 Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing acylated tRNA-substrates in the A and P sites.
5J4B 2016-04-27 2.6 Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (co-crystallized) and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution
5WIT 2018-02-14 2.6 Crystal structure of the Thermus thermophilus 70S ribosome in complex with pikromycin and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution
1G1X 2000-10-30 2.6 STRUCTURE OF RIBOSOMAL PROTEINS S15, S6, S18, AND 16S RIBOSOMAL RNA
4Z3S 2015-06-03 2.65 Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic A201A, mRNA and three tRNAs in the A, P and E sites at 2.65A resolution
4W2I 2014-10-15 2.7 Crystal structure of the Thermus thermophilus 70S ribosome in complex with negamycin, mRNA and three deacylated tRNAs in the A, P and E sites
4V8I 2014-07-09 2.7 Crystal structure of YfiA bound to the 70S ribosome.
5WIS 2018-02-14 2.7 Crystal structure of the Thermus thermophilus 70S ribosome in complex with methymycin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution
5HD1 2016-04-06 2.7 Crystal structure of antimicrobial peptide Pyrrhocoricin bound to the Thermus thermophilus 70S ribosome
4W2H 2014-10-15 2.7 Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (co-crystallized), mRNA and deacylated tRNA in the P site
5W4K 2017-08-30 2.7 Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution
6CFK 2018-03-07 2.7 Crystal structure of the Thermus thermophilus 70S ribosome in complex with D-histidyl-CAM and bound to protein Y (YfiA) at 2.7A resolution
6O97 2019-04-17 2.75 Crystal structure of the Thermus thermophilus 70S ribosome in complex with propylamycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.75A resolution
1VY7 2014-08-20 2.8 Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Cytidine-Puromycin in the A site and acylated tRNA in the P site.
4WQF 2015-01-28 2.8 Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G and fusidic acid in the post-translocational state
5FDV 2016-01-27 2.8 Crystal structure of the Pyrrhocoricin antimicrobial peptide bound to the Thermus thermophilus 70S ribosome
4V51 2014-07-09 2.8 Structure of the Thermus thermophilus 70S ribosome complexed with mRNA, tRNA and paromomycin
5F8K 2016-02-03 2.8 Crystal structure of the Bac7(1-16) antimicrobial peptide bound to the Thermus thermophilus 70S ribosome
6CFJ 2018-03-07 2.8 Crystal structure of the Thermus thermophilus 70S ribosome in complex with histidyl-CAM and bound to mRNA and A-, P-, and E-site tRNAs at 2.8A resolution
5HCR 2016-04-06 2.8 Crystal structure of antimicrobial peptide Oncocin 10wt bound to the Thermus thermophilus 70S ribosome
4WPO 2015-01-28 2.8 Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the pre-translocational state
3T1Y 2012-01-25 2.8 Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a human anti-codon stem loop (HASL) of transfer RNA Lysine 3 (TRNALYS3) bound to an mRNA with an AAG-codon in the A-site and paromomycin
2UUB 2007-05-15 2.8 Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUU-codon in the A-site and paromomycin.
6OF1 2019-04-17 2.8 Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution
5VP2 2017-06-28 2.8 Crystal structure of the Thermus thermophilus 70S ribosome in complex with madumycin II and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution
4WQY 2015-01-28 2.8 Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the post-translocational state (without fusitic acid)
5J4C 2016-04-27 2.8 Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (soaked) and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution
4WQU 2015-01-28 2.8 Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G trapped by the antibiotic dityromycin
5HCQ 2016-04-06 2.8 Crystal structure of antimicrobial peptide Oncocin d15-19 bound to the Thermus thermophilus 70S ribosome
6ND6 2019-02-20 2.85 Crystal structure of the Thermus thermophilus 70S ribosome in complex with erythromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.85A resolution
4V9H 2014-07-09 2.86 Crystal structure of the ribosome bound to elongation factor G in the guanosine triphosphatase state
5HCP 2016-04-06 2.89 Crystal structure of antimicrobial peptide Metalnikowin bound to the Thermus thermophilus 70S ribosome
4Z8C 2015-05-20 2.9 Crystal structure of the Thermus thermophilus 70S ribosome bound to translation inhibitor oncocin
1VY6 2014-08-20 2.9 Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Puromycin in the A site and acylated tRNA in the P site.
2UUA 2007-05-15 2.9 Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUC-codon in the A-site and paromomycin.
4W2E 2014-10-01 2.9 Crystal structure of Elongation Factor 4 (EF4/LepA) bound to the Thermus thermophilus 70S ribosome
4B3M 2013-08-07 2.9 Crystal structure of the 30S ribosome in complex with compound 1
2VQF 2008-04-29 2.9 Modified uridines with C5-methylene substituents at the first position of the tRNA anticodon stabilize U-G wobble pairing during decoding
5FDU 2016-01-27 2.9 Crystal structure of the Metalnikowin I antimicrobial peptide bound to the Thermus thermophilus 70S ribosome
2UXC 2007-05-08 2.9 Crystal structure of an extended tRNA anticodon stem loop in complex with its cognate mRNA UCGU in the context of the Thermus thermophilus 30S subunit.
4LNT 2014-08-06 2.94 Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-U on the Ribosome
5NDK 2017-12-13 2.95 Crystal structure of aminoglycoside TC007 co-crystallized with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA
4V90 2014-07-09 2.95 Thermus thermophilus Ribosome
4WSD 2015-06-10 2.95 Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site and with antibiotic paromomycin.
5E81 2016-01-27 2.95 Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with wobble pair
5IBB 2016-05-25 2.96 Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAVal in the A-site
6GSJ 2018-07-04 2.96 Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAThr in the A-site
5IB7 2016-05-25 2.99 Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet, near-cognate tRNALys with U-G mismatch in the A-site and antibiotic paromomycin
1FJG 2000-09-25 3.0 STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH THE ANTIBIOTICS STREPTOMYCIN, SPECTINOMYCIN, AND PAROMOMYCIN
4B3R 2013-08-07 3.0 Crystal structure of the 30S ribosome in complex with compound 30
4V7X 2014-07-09 3.0 Structure of the Thermus thermophilus ribosome complexed with erythromycin.
4V8B 2014-07-09 3.0 Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex).
4V67 2014-07-09 3.0 Crystal structure of a translation termination complex formed with release factor RF2.
4V9R 2014-07-09 3.0 Crystal structure of antibiotic DITYROMYCIN bound to 70S ribosome
4V7W 2014-07-09 3.0 Structure of the Thermus thermophilus ribosome complexed with chloramphenicol.
5HAU 2016-04-06 3.0 Crystal structure of antimicrobial peptide Bac7(1-19) bound to the Thermus thermophilus 70S ribosome
4V7Y 2014-07-09 3.0 Structure of the Thermus thermophilus 70S ribosome complexed with azithromycin.
4V8D 2014-07-09 3.0 Structure analysis of ribosomal decoding (cognate tRNA-tyr complex).
4B3T 2013-08-07 3.0 Crystal structure of the 30S ribosome in complex with compound 39
1XMQ 2004-12-14 3.0 Crystal Structure of t6A37-ASLLysUUU AAA-mRNA Bound to the Decoding Center
1N32 2002-11-29 3.0 Structure of the Thermus thermophilus 30S ribosomal subunit bound to codon and near-cognate transfer RNA anticodon stem-loop mismatched at the first codon position at the a site with paromomycin
4V7L 2014-07-09 3.0 The structures of viomycin bound to the 70S ribosome.
4V8G 2014-07-09 3.0 Crystal structure of RMF bound to the 70S ribosome.
4LFB 2014-07-02 3.01 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
5J3C 2016-10-12 3.04 Thermus thermophilus 70S termination complex containing E. coli RF1
4WR6 2015-06-10 3.05 Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site.
4WT1 2015-06-10 3.05 Complex of 70S ribosome with tRNA-Phe and mRNA with A-A mismatch in the second position in the A-site
4WRA 2015-06-10 3.05 Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site and with antibiotic paromomycin.
1J5E 2002-04-12 3.05 Structure of the Thermus thermophilus 30S Ribosomal Subunit
1XNQ 2004-12-14 3.05 Structure of an Inosine-Adenine Wobble Base Pair Complex in the Context of the Decoding Center
4WRO 2015-06-10 3.05 Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site
4KHP 2013-06-05 3.1 Structure of the Thermus thermophilus 30S ribosomal subunit in complex with de-6-MSA-pactamycin
4WZD 2015-06-10 3.1 Complex of 70S ribosome with cognate tRNA-Tyr in the P-site
4V8H 2014-07-09 3.1 Crystal structure of HPF bound to the 70S ribosome.
4WQ1 2015-06-10 3.1 Complex of 70S ribosome with tRNA-Tyr and mRNA with C-A mismatch in the first position in the A-site.
4V8N 2014-07-09 3.1 The crystal structure of agmatidine tRNA-Ile2 bound to the 70S ribosome in the A and P site.
5DOX 2015-12-30 3.1 Crystal structure of the Thermus thermophilus 70S ribosome in complex with Hygromycin-A at 3.1A resolution
1XNR 2004-12-14 3.1 Crystal Structure of an Inosine-Cytosine Wobble Base Pair in the Context of the Decoding Center
2UU9 2007-05-15 3.1 Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUG-codon in the A-site and paromomycin.
4V5P 2014-07-09 3.1 The crystal structure of EF-Tu and A9C-tRNA-Trp bound to a near- cognate codon on the 70S ribosome
4V5L 2014-07-09 3.1 The structure of EF-Tu and aminoacyl-tRNA bound to the 70S ribosome with a GTP analog
4V6F 2014-07-09 3.1 Elongation complex of the 70S ribosome with three tRNAs and mRNA.
5EL6 2016-01-27 3.1 Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position and antibiotic paromomycin
4YZV 2015-10-21 3.1 Precleavage 70S structure of the P. vulgaris HigB deltaH92 toxin bound to the ACA codon
4V5Q 2014-07-09 3.1 The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a near- cognate codon on the 70S ribosome
4V9B 2014-07-09 3.1 Crystal Structure of the 70S ribosome with tigecycline.
4V5J 2014-07-09 3.1 Structure of the 70S ribosome bound to Release factor 2 and a substrate analog provides insights into catalysis of peptide release
6QNR 2019-06-19 3.1 70S ribosome elongation complex (EC) with experimentally assigned potassium ions
4ZER 2015-05-20 3.1 Crystal structure of the Onc112 antimicrobial peptide bound to the Thermus thermophilus 70S ribosome
4V9S 2014-07-09 3.1 Crystal structure of antibiotic GE82832 bound to 70S ribosome
4V8Q 2014-07-09 3.1 Complex of SmpB, a tmRNA fragment and EF-Tu-GDP-Kirromycin with the 70S ribosome
5J4D 2016-05-18 3.1 E. coli release factor 1 bound to the 70S ribosome in response to a pseudouridylated stop codon
4V5R 2014-07-09 3.1 The crystal structure of EF-Tu and Trp-tRNA-Trp bound to a cognate codon on the 70S ribosome.
4JYA 2013-06-26 3.1 Crystal structures of pseudouridinilated stop codons with ASLs
4V7Z 2014-07-09 3.1 Structure of the Thermus thermophilus 70S ribosome complexed with telithromycin.
4V5S 2014-07-09 3.1 The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a cognate codon on the 70S ribosome.
2UXB 2007-07-31 3.1 Crystal structure of an extended tRNA anticodon stem loop in complex with its cognate mRNA GGGU in the context of the Thermus thermophilus 30S subunit.
4V87 2014-07-09 3.1 Crystal structure analysis of ribosomal decoding.
2UUC 2007-05-22 3.1 Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUA-codon in the A-site and paromomycin.
4V6A 2014-07-09 3.1 Structure of EF-P bound to the 70S ribosome.
5DFE 2016-10-12 3.1 70S termination complex containing E. coli RF2
3T1H 2012-01-25 3.11 Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a human anti-codon stem loop (HASL) of transfer RNA lysine 3 (tRNALys3) bound to an mRNA with an AAA-codon in the A-site and Paromomycin
1IBL 2001-05-04 3.11 STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH A MESSENGER RNA FRAGMENT AND COGNATE TRANSFER RNA ANTICODON STEM-LOOP BOUND AT THE A SITE AND WITH THE ANTIBIOTIC PAROMOMYCIN
5IB8 2016-05-25 3.13 Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNALys with U-G mismatch in the A-site
4LT8 2014-08-06 3.14 Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-G on the Ribosome
6CZR 2019-04-10 3.14 The structure of amicetin bound to the 70S ribosome
4JI1 2013-11-06 3.14 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4LF7 2014-07-02 3.15 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4LF8 2014-07-02 3.15 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4B3S 2013-08-07 3.15 Crystal structure of the 30S ribosome in complex with compound 37
5EL4 2016-01-27 3.15 Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position
5NDJ 2018-05-02 3.15 Crystal structure of aminoglycoside TC007 in complex with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA (soaking)
4WQR 2015-06-10 3.15 Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the first position in the A-site.
5EL7 2016-01-27 3.15 Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position and antibiotic paromomycin
5EL5 2016-01-27 3.15 Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position
4JV5 2013-06-26 3.16 Crystal structures of pseudouridinilated stop codons with ASLs
6GSL 2018-07-04 3.16 Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAArg in the A-site
6BZ6 2018-11-14 3.18 Thermus thermophilus 70S complex containing 16S G347U ram mutation and empty A site
4WU1 2015-06-10 3.2 Complex of 70S ribosome with tRNA-Tyr and mRNA with G-U mismatch in the second position in the P-site
6C5L 2018-02-21 3.2 Conformation of methylated GGQ in the Peptidyl Transferase Center during translation termination (T. thermophilus)
6FKR 2018-03-28 3.2 Crystal structure of the dolphin proline-rich antimicrobial peptide Tur1A bound to the Thermus thermophilus 70S ribosome
5J30 2016-10-12 3.2 Thermus thermophilus 70S termination complex containing E. coli RF1
1I94 2001-04-12 3.2 CRYSTAL STRUCTURES OF THE SMALL RIBOSOMAL SUBUNIT WITH TETRACYCLINE, EDEINE AND IF3
4V95 2014-07-09 3.2 Crystal structure of YAEJ bound to the 70S ribosome
5E7K 2016-01-27 3.2 Structure of T. thermophilus 70S ribosome complex with mRNA and cognate tRNALys in the A-site
4GKK 2013-06-05 3.2 Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a human mitochondrial anticodon stem loop (ASL) of transfer RNA Methionine (TRNAMET) bound to an mRNA with an AUA-codon in the A-site and paromomycin
4V5K 2014-07-09 3.2 Structure of cytotoxic domain of colicin E3 bound to the 70S ribosome
2UXD 2007-10-02 3.2 Crystal structure of an extended tRNA anticodon stem loop in complex with its cognate mRNA CGGG in the context of the Thermus thermophilus 30S subunit.
1HR0 2001-01-24 3.2 CRYSTAL STRUCTURE OF INITIATION FACTOR IF1 BOUND TO THE 30S RIBOSOMAL SUBUNIT
5UQ8 2018-03-07 3.2 70S ribosome complex with dnaX mRNA stem-loop and E-site tRNA ('out' conformation)
6N1D 2019-04-03 3.2 X-ray Crystal complex showing Spontaneous Ribosomal Translocation of mRNA and tRNAs into a Chimeric Hybrid State
4V8A 2014-07-09 3.2 The structure of thermorubin in complex with the 70S ribosome from Thermus thermophilus.
4V63 2014-07-09 3.21 Structural basis for translation termination on the 70S ribosome.
4L47 2014-08-06 3.22 Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U on the Ribosome
1XMO 2004-12-14 3.25 Crystal Structure of mnm5U34t6A37-tRNALysUUU Complexed with AAG-mRNA in the Decoding Center
4DR2 2012-11-14 3.25 Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with multiple copies of paromomycin molecules bound
5V8I 2018-03-28 3.25 Thermus thermophilus 70S ribosome lacking ribosomal protein uS17
4LF9 2014-07-02 3.28 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
6GZQ 2018-10-24 3.28 T. thermophilus hibernating 70S ribosome
4DV7 2013-02-27 3.29 Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, A915G, bound with streptomycin
4GKJ 2013-06-05 3.3 Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a human mitochondrial anticodon stem loop (ASL) of transfer RNA Methionine (TRNAMET) bound to an mRNA with an AUG-codon in the A-site and paromomycin.
2E5L 2007-05-15 3.3 A snapshot of the 30S ribosomal subunit capturing mRNA via the Shine- Dalgarno interaction
5CZP 2016-10-12 3.3 70S termination complex containing E. coli RF2
4V8C 2014-07-09 3.3 Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex with paromomycin).
4V9I 2014-07-09 3.3 Crystal structure of thermus thermophilus 70S in complex with tRNAs and mRNA containing a pseudouridine in a stop codon
5WNV 2018-02-21 3.3 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4V8E 2014-07-09 3.3 Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).
1HNZ 2001-02-21 3.3 STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH HYGROMYCIN B
4WSM 2015-06-10 3.3 Complex of 70S ribosome with tRNA-Leu and mRNA with G-U mismatch in the first position in the A- and P-sites
2ZM6 2009-04-14 3.3 Crystal structure of the Thermus thermophilus 30S ribosomal subunit
4V7J 2014-07-09 3.3 Structure of RelE nuclease bound to the 70S ribosome (precleavage state)
1FKA 2000-09-04 3.3 STRUCTURE OF FUNCTIONALLY ACTIVATED SMALL RIBOSOMAL SUBUNIT AT 3.3 A RESOLUTION
4DV6 2013-02-27 3.3 Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, A915G
5WNP 2018-02-21 3.3 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
5WNT 2018-02-21 3.3 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4V8F 2014-07-09 3.3 Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).
4V9A 2014-07-09 3.3 Crystal Structure of the 70S ribosome with tetracycline.
4WZO 2015-06-10 3.3 Complex of 70S ribosome with tRNA-fMet and mRNA
4W4G 2015-10-21 3.3 Postcleavage state of 70S bound to HigB toxin and AAA (lysine) codon
4DR6 2012-11-14 3.3 Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, near-cognate transfer RNA anticodon stem-loop mismatched at the first codon position and streptomycin bound
4V5C 2014-07-09 3.3 Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A-site tRNA, deacylated P-site tRNA, and E-site tRNA.
1IBK 2001-05-04 3.31 STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH THE ANTIBIOTIC PAROMOMYCIN
1IBM 2001-05-04 3.31 STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH A MESSENGER RNA FRAGMENT AND COGNATE TRANSFER RNA ANTICODON STEM-LOOP BOUND AT THE A SITE
4LF6 2014-07-02 3.31 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
6MPF 2019-04-24 3.33 Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a 2-thiocytidine (s2C32) and inosine (I34) modified anticodon stem loop (ASL) of Escherichia coli transfer RNA Arginine 1 (TRNAARG1) bound to an mRNA with an CGC-codon in the A-site and paromomycin
6MPI 2019-04-24 3.33 Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a 2-thiocytidine (s2C32) and inosine (I34) modified anticodon stem loop (ASL) of Escherichia coli transfer RNA Arginine 1 (TRNAARG1) bound to an mRNA with an CGU-codon in the A-site and paromomycin
5VPO 2018-09-26 3.34 The 70S P-site ASL SufA6 complex
4LF4 2014-07-02 3.34 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4DR3 2012-11-14 3.35 Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with streptomycin bound
1N33 2002-11-29 3.35 Structure of the Thermus thermophilus 30S ribosomal subunit bound to codon and near-cognate transfer rna anticodon stem-loop mismatched at the second codon position at the a site with paromomycin
4JI3 2013-11-06 3.35 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4V8X 2014-07-09 3.35 Structure of Thermus thermophilus ribosome
4X64 2015-11-18 3.35 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4X65 2015-11-18 3.35 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
2HHH 2006-09-26 3.35 Crystal structure of kasugamycin bound to the 30S ribosomal subunit
6GSK 2018-07-04 3.36 Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNAThr in the A-site
4DUY 2013-02-27 3.39 Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, U13C
5BR8 2015-11-18 3.4 Ambient-temperature crystal structure of 30S ribosomal subunit from Thermus thermophilus in complex with paromomycin
4V9Q 2014-07-09 3.4 Crystal Structure of Blasticidin S Bound to Thermus Thermophilus 70S Ribosome.
1HNX 2001-02-21 3.4 STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH PACTAMYCIN
6B4V 2018-02-07 3.4 Antibiotic blasticidin S and E. coli release factor 1 bound to the 70S ribosome
6CAQ 2018-07-25 3.4 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
6CAR 2018-07-25 3.4 Serial Femtosecond X-ray Crystal Structure of 30S ribosomal subunit from Thermus thermophilus in complex with Sisomicin
1HNW 2001-02-21 3.4 STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH TETRACYCLINE
4YPB 2015-10-21 3.4 Precleavage 70S structure of the P. vulgaris HigB DeltaH92 toxin bound to the AAA codon
6BOH 2018-05-23 3.4 Antibiotic blasticidin S and E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome
4V9N 2014-07-09 3.4 Crystal structure of the 70S ribosome bound with the Q253P mutant of release factor RF2.
4K0K 2013-06-26 3.4 Crystal structure of the Thermus thermophilus 30S ribosomal subunit complexed with a serine-ASL and mRNA containing a stop codon
4WT8 2015-01-21 3.4 Crystal Structure of bactobolin A bound to 70S ribosome-tRNA complex
6CAP 2018-07-25 3.4 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus in complex with Sisomicin
5WNU 2018-02-21 3.4 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4V84 2014-07-09 3.4 Crystal structure of a complex containing domain 3 of CrPV IGR IRES RNA bound to the 70S ribosome.
4YHH 2015-04-08 3.42 Crystal structure of the 30S ribosomal subunit from Thermus thermophilus in complex with tigecycline
1VVJ 2014-08-06 3.44 Crystal Structure of Frameshift Suppressor tRNA SufA6 bound to Codon CCC-G on the Ribosome
4V7M 2014-07-09 3.45 The structures of Capreomycin bound to the 70S ribosome.
4V5E 2014-07-09 3.45 Insights into translational termination from the structure of RF2 bound to the ribosome
4DR5 2012-11-14 3.45 Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, crystallographically disordered cognate transfer RNA anticodon stem-loop and streptomycin bound
4X66 2015-11-18 3.45 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4X62 2015-11-18 3.45 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
6CAO 2018-07-25 3.45 Structure of the ribosomal decoding complex at ambient temperature
6MKN 2019-04-24 3.46 Structure of the Thermus thermophilus 30S ribosomal subunit complexed with an inosine (I34) modified anticodon stem loop (ASL) of Escherichia coli transfer RNA Arginine 2 (TRNAARG2) bound to an mRNA with an CGU-codon in the A-site and paromomycin
4LSK 2014-08-06 3.48 Crystal Structure of tRNA Proline (CGG) Bound to Codon CCG-G on the Ribosome
4JI0 2013-11-06 3.49 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
5WNS 2018-02-21 3.5 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4V5A 2014-07-09 3.5 Structure of the Ribosome Recycling Factor bound to the Thermus thermophilus 70S ribosome with mRNA, ASL-Phe and tRNA-fMet
6BUW 2018-11-14 3.5 Thermus thermophilus 70S complex containing 16S G299A ram mutation and empty A site.
5WNQ 2018-02-21 3.5 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
6QNQ 2019-06-19 3.5 70S ribosome initiation complex (IC) with experimentally assigned potassium ions
4V9K 2014-07-09 3.5 70S ribosome translocation intermediate GDPNP-I containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.
4JI7 2013-11-06 3.5 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4TUE 2015-05-13 3.5 Crystal structure of ASL-SufJ bound to Codon ACC-U on the Ribosome
5WNR 2018-02-21 3.5 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4AQY 2012-07-18 3.5 Structure of ribosome-apramycin complexes
5IWA 2016-04-27 3.5 Crystal structure of the 30S ribosomal subunit from Thermus thermophilus in complex with the GE81112 peptide antibiotic
4V5D 2014-07-09 3.5 Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A- and P-site tRNAs, and E-site tRNA.
6CAS 2018-07-25 3.5 Serial Femtosecond X-ray Crystal Structure of 30S ribosomal subunit from Thermus thermophilus in complex with N1MS
4V83 2014-07-09 3.5 Crystal structure of a complex containing domain 3 from the PSIV IGR IRES RNA bound to the 70S ribosome.
4V6G 2014-07-09 3.5 Initiation complex of 70S ribosome with two tRNAs and mRNA.
5UQ7 2018-03-07 3.5 70S ribosome complex with dnaX mRNA stemloop and E-site tRNA ('in' conformation)
4V9L 2014-07-09 3.5 70S Ribosome translocation intermediate FA-3.6A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.
4V97 2014-07-09 3.52 Crystal structure of the bacterial ribosome ram mutation G299A.
4NXN 2014-05-21 3.54 Crystal Structure of the 30S ribosomal subunit from a GidB (RsmG) mutant of Thermus thermophilus (HB8), bound with streptomycin
6DTI 2019-04-24 3.54 Structure of the Thermus thermophilus 30S ribosomal subunit complexed with an unmodifed anticodon stem loop (ASL) of Escherichia coli transfer RNA Arginine 2 (TRNAARG2) bound to an mRNA with an CGU-codon in the A-site and paromomycin
5LMN 2016-10-05 3.55 Structure of bacterial 30S-IF1-IF3-mRNA translation pre-initiation complex (state-1A)
4DV3 2013-02-27 3.55 Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, C912A, bound with streptomycin
4JI6 2013-11-06 3.55 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
6BOK 2018-05-23 3.55 E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome
4TUB 2015-05-13 3.6 Crystal structure of tRNA-Thr bound to Codon ACC-C on the Ribosome
4V5F 2014-07-09 3.6 The structure of the ribosome with elongation factor G trapped in the post-translocational state
4YY3 2016-07-06 3.6 30S ribosomal subunit- HigB complex
4DR1 2012-11-14 3.6 Crystal structure of the apo 30S ribosomal subunit from Thermus thermophilus (HB8)
4TUA 2015-05-13 3.6 Crystal structure of ASL-Thr bound to Codon ACC-A on the Ribosome
4LFC 2014-07-02 3.6 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4TUC 2015-05-13 3.6 Crystal structure of ASL-SufJ bound to Codon ACC-A on the Ribosome
5ZLU 2018-08-01 3.6 Ribosome Structure bound to ABC-F protein.
4ZSN 2016-09-07 3.6 70S-wild-type HigB toxin complex bound to a AAA lysine codon
4V7K 2014-07-09 3.6 Structure of RelE nuclease bound to the 70S ribosome (postcleavage state)
4TUD 2015-05-13 3.6 Crystal structure of ASL-SufJ bound to Codon ACC-C on the Ribosome
4V5G 2014-07-09 3.6 The crystal structure of the 70S ribosome bound to EF-Tu and tRNA
4P6F 2014-10-01 3.6 Crystal structure of the peptolide 12C bound to bacterial ribosome
4V7P 2014-07-09 3.62 Recognition of the amber stop codon by release factor RF1.
5D8B 2015-10-14 3.63 Crystal structure of T. thermophilus ribosome containing a P-site wobble mismatch
6NDK 2019-02-27 3.64 Structure of ASLSufA6 A37.5 bound to the 70S A site
4JI2 2013-11-06 3.64 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4DV4 2013-02-27 3.65 Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, A914G
4DUZ 2013-02-27 3.65 Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, U13C, bound with streptomycin
4LFA 2014-07-02 3.65 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
1N36 2002-11-29 3.65 Structure of the Thermus thermophilus 30S ribosomal subunit in the presence of crystallographically disordered codon and near-cognate transfer RNA anticodon stem-loop mismatched at the second codon position
4NXM 2014-05-21 3.65 Crystal Structure of the 30S ribosomal subunit from a GidB (RsmG) mutant of Thermus thermophilus (HB8)
4DV2 2013-02-27 3.65 Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, C912A
4P70 2014-08-13 3.68 Crystal Structure of Unmodified tRNA Proline (CGG) Bound to Codon CCG on the Ribosome
4DV5 2013-02-27 3.68 Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, A914G, bound with streptomycin
6BZ7 2018-11-14 3.68 Thermus thermophilus 70S containing 16S G299A point mutation and near-cognate ASL Leucine in A site.
4JI4 2013-11-06 3.69 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
3OTO 2010-09-29 3.69 Crystal Structure of the 30S ribosomal subunit from a KsgA mutant of Thermus thermophilus (HB8)
4V8U 2014-07-09 3.7 Crystal Structure of 70S Ribosome with Both Cognate tRNAs in the E and P Sites Representing an Authentic Elongation Complex.
6Q95 2019-02-27 3.7 Structure of tmRNA SmpB bound in A site of T. thermophilus 70S ribosome
4V4I 2014-07-09 3.71 Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements.
6BZ8 2018-11-14 3.74 Thermus thermophilus 70S containing 16S G347U point mutation and near-cognate ASL Leucine in A site
4JI8 2013-11-06 3.74 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4DR7 2012-11-14 3.75 Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, crystallographically disordered near-cognate transfer RNA anticodon stem-loop mismatched at the second codon position, and streptomycin bound
4LF5 2014-07-02 3.75 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4V8O 2014-07-09 3.8 Crystal structure of the hybrid state of ribosome in complex with the guanosine triphosphatase release factor 3
4W29 2014-10-01 3.8 70S ribosome translocation intermediate containing elongation factor EFG/GDP/fusidic acid, mRNA, and tRNAs trapped in the AP/AP pe/E chimeric hybrid state.
2F4V 2006-07-04 3.8 30S ribosome + designer antibiotic
4XEJ 2015-02-25 3.8 IRES bound to bacterial Ribosome
4OX9 2014-04-09 3.8 Crystal structure of the aminoglycoside resistance methyltransferase NpmA bound to the 30S ribosomal subunit
1N34 2002-11-29 3.8 Structure of the Thermus thermophilus 30S ribosomal subunit in the presence of codon and crystallographically disordered near-cognate transfer rna anticodon stem-loop mismatched at the first codon position
5IMQ 2016-05-18 3.8 Structure of ribosome bound to cofactor at 3.8 angstrom resolution
5OT7 2018-02-14 3.8 Elongation factor G-ribosome complex captures in the absence of inhibitors.
4V4J 2014-07-09 3.83 Interactions and Dynamics of the Shine-Dalgarno Helix in the 70S Ribosome.
4DV1 2013-02-27 3.85 Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, U20G, bound with streptomycin
4DV0 2013-02-27 3.85 Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, U20G
4JI5 2013-11-06 3.85 Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4V9J 2014-07-09 3.86 70S ribosome translocation intermediate GDPNP-II containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.
4L71 2014-08-06 3.9 Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-A on the Ribosome
4LEL 2014-08-06 3.9 Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCG-G on the Ribosome
5VPP 2018-09-26 3.9 The 70S P-site tRNA SufA6 complex
4V8J 2014-07-09 3.9 Crystal structure of the bacterial ribosome ram mutation G347U.
4LFZ 2014-08-06 3.92 Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U in the Absence of Paromomycin
4DR4 2012-11-14 3.97 Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, cognate transfer RNA anticodon stem-loop and multiple copies of paromomycin molecules bound
4V9M 2014-07-09 4.0 70S Ribosome translocation intermediate FA-4.2A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.
5LMU 2016-10-05 4.0 Structure of bacterial 30S-IF3-mRNA-tRNA translation pre-initiation complex, closed form (state-4)
6GZZ 2018-10-24 4.13 T. thermophilus hibernating 100S ribosome (amc)
5LMT 2016-10-05 4.15 Structure of bacterial 30S-IF1-IF3-mRNA-tRNA translation pre-initiation complex(state-3)
5LMQ 2016-10-05 4.2 Structure of bacterial 30S-IF1-IF3-mRNA-tRNA translation pre-initiation complex, open form (state-2A)
1I96 2001-04-12 4.2 CRYSTAL STRUCTURE OF THE 30S RIBOSOMAL SUBUNIT FROM THERMUS THERMOPHILUS IN COMPLEX WITH THE TRANSLATION INITIATION FACTOR IF3 (C-TERMINAL DOMAIN)
4KVB 2014-06-04 4.2 Thermus thermophilus HB27 30S ribosomal subunit lacking ribosomal protein S17
5LMO 2016-10-05 4.3 Structure of bacterial 30S-IF1-IF3-mRNA translation pre-initiation complex (state-1B)
5LMR 2016-10-05 4.45 Structure of bacterial 30S-IF1-IF3-mRNA-tRNA translation pre-initiation complex(state-2B)
1I97 2001-04-12 4.5 CRYSTAL STRUCTURE OF THE 30S RIBOSOMAL SUBUNIT FROM THERMUS THERMOPHILUS IN COMPLEX WITH TETRACYCLINE
1I95 2001-04-12 4.5 CRYSTAL STRUCTURE OF THE 30S RIBOSOMAL SUBUNIT FROM THERMUS THERMOPHILUS IN COMPLEX WITH EDEINE
4V4Z 2014-07-09 4.51 70S Thermus thermophilous ribosome functional complex with mRNA and E- and P-site tRNAs at 4.5A.
6GZX 2018-10-24 4.57 T. thermophilus hibernating 100S ribosome (ice)
5A9Z 2015-10-14 4.7 Complex of Thermous thermophilus ribosome bound to BipA-GDPCP
5LMV 2016-10-05 4.9 Structure of bacterial 30S-IF1-IF2-IF3-mRNA-tRNA translation pre-initiation complex(state-III)
5AA0 2015-10-14 5.0 Complex of Thermous thermophilus ribosome (A-and P-site tRNA) bound to BipA-GDPCP
1JGQ 2001-07-20 5.0 The Path of Messenger RNA Through the Ribosome. THIS FILE, 1JGQ, CONTAINS THE 30S RIBOSOME SUBUNIT, THREE TRNA, AND MRNA MOLECULES. 50S RIBOSOME SUBUNIT IS IN THE FILE 1GIY
4V4X 2014-07-09 5.0 Crystal structure of the 70S Thermus thermophilus ribosome showing how the 16S 3'-end mimicks mRNA E and P codons.
5LMS 2016-10-05 5.1 Structure of bacterial 30S-IF1-IF3-mRNA-tRNA translation pre-initiation complex(state-2C)
5LMP 2016-10-05 5.35 Structure of bacterial 30S-IF1-IF3-mRNA translation pre-initiation complex (state-1C)
4V4Y 2014-07-09 5.5 Crystal structure of the 70S Thermus thermophilus ribosome with translocated and rotated Shine-Dalgarno Duplex.
4V42 2014-07-09 5.5 Crystal structure of the ribosome at 5.5 A resolution.
1QD7 1999-08-31 5.5 PARTIAL MODEL FOR 30S RIBOSOMAL SUBUNIT
4V4P 2014-07-09 5.5 Crystal structure of 70S ribosome with thrS operator and tRNAs.
1JGO 2001-07-20 5.6 The Path of Messenger RNA Through the Ribosome. THIS FILE, 1JGO, CONTAINS THE 30S RIBOSOME SUBUNIT, THREE TRNA, AND MRNA MOLECULES. 50S RIBOSOME SUBUNIT IS IN THE FILE 1GIY
5IMR 2016-05-18 5.7 Structure of ribosome bound to cofactor at 5.7 angstrom resolution
4V4R 2014-07-09 5.9 Crystal structure of the whole ribosomal complex.
4V68 2014-07-09 6.4 T. thermophilus 70S ribosome in complex with mRNA, tRNAs and EF-Tu.GDP.kirromycin ternary complex, fitted to a 6.4 A Cryo-EM map.
4V4T 2014-07-09 6.46 Crystal structure of the whole ribosomal complex with a stop codon in the A-site.
4V4S 2014-07-09 6.76 Crystal structure of the whole ribosomal complex.
1JGP 2001-07-20 7.0 The Path of Messenger RNA Through the Ribosome. THIS FILE, 1JGP, CONTAINS THE 30S RIBOSOME SUBUNIT, THREE TRNA, AND MRNA MOLECULES. 50S RIBOSOME SUBUNIT IS IN THE FILE 1GIY
4V5N 2014-07-09 7.6 tRNA translocation on the 70S ribosome: the post- translocational translocation intermediate TI(POST)
4V5M 2014-07-09 7.8 tRNA tranlocation on the 70S ribosome: the pre-translocational translocation intermediate TI(PRE)

Relevant UniProtKB Entries

Percent Identity Matching Chains Protein Accession Entry Name
100.0 30S ribosomal protein S6 P23370 RS6_THETH
100.0 30S ribosomal protein S6 Q5SLP8 RS6_THET8
100.0 30S ribosomal protein S6 P62666 RS6_THET2