Molecular recognition in the HIV-1 capsid/cyclophilin A complex.


Abstract

The HIV-1 capsid protein (CA) makes an essential interaction with the human peptidyl prolyl isomerase, cyclophilin A (CypA), that results in packaging of CypA into the virion at a CA to CypA stoichiometry of approximately 10:1. The 231 amino acid residue capsid protein is composed of an amino-terminal CypA binding domain (1 to approximately 151; CA151) and a carboxyl-terminal dimerization domain (approximately 151 to 231). We find that CypA binds dimeric CA and monomeric CA151 with identical intrinsic affinities (K[d] = 16(+/-4) microM). This result demonstrates that capsid dimerization and cyclophilin A binding are not thermodynamically coupled and suggests that the substoichiometric ratio of CypA in the HIV-1 virion results from the intrinsic stability of the CA/CypA complex. In the known co-crystal structure of the CA151/CypA complex, CypA binding is mediated exclusively by an exposed capsid loop that spans residues Pro85 to Pro93. The energetic contributions to CypA binding were quantified for each residue in this loop, and the results demonstrate that the Gly89-Pro90 dipeptide is the primary cyclophilin A recognition motif, with Pro85, Val86, His87, Ala88, and Pro93 also making energetically favorable contacts. These studies reveal that the active site of CypA, which can catalyze the isomerization of proline residues in vitro, also functions as a sequence-specific, protein-binding motif in HIV-1 replication.

Submission Details

ID: AXsUwn94

Submitter: Shu-Ching Ou

Submission Date: Feb. 22, 2019, 12:13 p.m.

Version: 1

Publication Details
Yoo S;Myszka DG;Yeh C;McMurray M;Hill CP;Sundquist WI,J Mol Biol (1997) Molecular recognition in the HIV-1 capsid/cyclophilin A complex. PMID:9223641
Additional Information

Two sets of ΔΔG values are reported. One is from direct calculations using relative Kd, and the other set is reported from the AB-Bind article (DOI: 10.1002/pro.2829)

Structure view and single mutant data analysis

Study data

No weblogo for data of varying length.
Colors: D E R H K S T N Q A V I L M F Y W C G P
 

Data Distribution

Studies with similar sequences (approximate matches)

Correlation with other assays (exact sequence matches)


Relevant PDB Entries

Structure ID Release Date Resolution Structure Title
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3TOG 2012-08-15 1.24 HIV-1 Protease - Epoxydic Inhibitor Complex (pH 9 - Monoclinic Crystal form P21)
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3PWR 2011-04-20 1.45 HIV-1 Protease Mutant L76V complexed with Saquinavir
5NOT 2017-07-12 1.45 Structure of cyclophilin A in complex with 4-chloropyrimidin-5-amine
3B7V 2007-12-18 1.46 HIV-1 protease complexed with gem-diol-amine tetrahedral intermediate NLLTQI
3PWM 2011-04-20 1.46 HIV-1 Protease Mutant L76V with Darunavir
6B3F 2018-01-03 1.46 Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,5S)-5-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide
4HEG 2013-08-21 1.46 Crystal Structure of HIV-1 protease mutants R8Q complexed with inhibitor GRL-0519
6O48 2019-06-19 1.46 Wild-type HIV-1 protease in complex with a substrate analog CA-p2
4N1S 2015-08-12 1.47 Structure of Cyclophilin A in complex with benzohydrazide.
6B38 2018-01-03 1.48 Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,6R)-6-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide
5NOW 2017-07-12 1.48 Structure of cyclophilin A in complex with pyridine-3,4-diamine
2QNN 2008-04-15 1.48 HIV-1 protease in complex with a multiple decorated pyrrolidine-based inhibitor
6DIL 2018-10-17 1.48 HIV-1 protease with single mutation L76V in complex with tipranavir
4YUK 2015-10-14 1.48 Multiconformer synchrotron model of CypA at 260 K
5TA2 2017-01-25 1.48 Discovery of a Potent Cyclophilin Inhibitor (Compound 7) based on Structural Simplification of Sanglifehrin A
6MCR 2019-04-24 1.48 X-ray crystal structure of wild type HIV-1 protease in complex with GRL-001
4YUG 2015-10-14 1.48 Multiconformer synchrotron model of CypA at 100 K
5JFP 2016-09-21 1.49 HIV-1 wild Type protease with GRL-097-13A (a Adamantane P1-Ligand with bis-THF in P2 and isobutylamine in P1')
5NOX 2017-07-12 1.49 Structure of cyclophilin A in complex with 2-chloropyridin-3-amine
4HDB 2013-08-14 1.49 Crystal Structure of HIV-1 protease mutants D30N complexed with inhibitor GRL-0519
5TA4 2017-01-25 1.5 Discovery of a Potent Cyclophilin Inhibitor (Compound 8) based on Structural Simplification of Sanglifehrin A
5YOJ 2018-07-11 1.5 Structure of A17 HIV-1 Protease in Complex with Inhibitor KNI-1657
4DQB 2012-03-07 1.5 Crystal Structure of wild-type HIV-1 Protease in Complex with DRV
3NUJ 2010-08-25 1.5 Crystal Structure of HIV-1 Protease Mutant I54V with Antiviral Drug Amprenavir
5AHC 2015-05-06 1.5 Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
1XL2 2005-06-07 1.5 HIV-1 Protease in complex with pyrrolidinmethanamine
3WNH 2013-12-25 1.5 Cyclic hexapeptide PKZDNv in complex with HIV-1 integrase
2WLW 2009-09-22 1.5 Structure of the N-terminal capsid domain of HIV-2
4Q1Y 2015-02-18 1.5 Mutations Outside the Active Site of HIV-1 Protease Alter Enzyme Structure and Dynamic Ensemble of the Active Site to Confer Drug Resistance
4NX4 2014-02-26 1.5 Re-refinement of CAP-1 HIV-CA complex
3NWQ 2011-11-02 1.5 X-ray structure of ester chemical analogue [O-Ile50,O-Ile50']HIV-1 protease complexed with MVT-101
5AH6 2015-05-06 1.5 Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
4A6C 2012-05-09 1.5 Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based HIV-1 Protease Inhibitors
2FGV 2006-11-07 1.5 X-ray crystal structure of HIV-1 Protease T80N variant in complex with the inhibitor saquinavir used to explore the role of invariant Thr80 in HIV-1 protease structure, function, and viral infectivity.
5HSV 2017-08-16 1.5 X-Ray structure of a CypA-Alisporivir complex at 1.5 angstrom resolution
4N1N 2015-08-12 1.5 Structure of Cyclophilin A in complex with Benzamide.
4QJ6 2014-10-29 1.5 Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with p1-p6 substrate variant (L449F)
2PWR 2008-04-15 1.5 HIV-1 protease in complex with a carbamoyl decorated pyrrolidine-based inhibitor
3B80 2007-12-18 1.5 HIV-1 protease mutant I54V complexed with gem-diol-amine intermediate NLLTQI
2AVV 2006-01-24 1.5 Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, and G73S
6B3G 2018-01-03 1.5 Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,6S)-6-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide
6BTA 2018-04-18 1.5 CypA Mutant - S99T C115S
4YUM 2015-10-14 1.5 Multiconformer synchrotron model of CypA at 300 K
5AHB 2015-05-06 1.5 Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
4G1Q 2013-02-06 1.51 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with Rilpivirine (TMC278, Edurant), a non-nucleoside rt-inhibiting drug
6MCS 2019-04-24 1.52 X-ray crystal structure of wild type HIV-1 protease in complex with GRL-003
5ULT 2017-05-03 1.53 HIV-1 wild Type protease with GRL-100-13A (a Crown-like Oxotricyclic Core as the P2-Ligand with the sulfonamide isostere as the P2' group)
4ZLS 2015-07-15 1.53 HIV-1 wild Type protease with GRL-096-13A (a Boc-derivative P2-Ligand, 3,-5-dimethylbiphenyl P1-Ligand)
2AOE 2006-01-17 1.54 crystal structure analysis of HIV-1 protease mutant V82A with a substrate analog CA-P2
3ZPT 2013-11-06 1.54 Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors
4QJA 2014-10-29 1.54 Crystal structure of inactive HIV-1 protease in complex with p1-p6 substrate variant (P453L)
4E43 2012-05-30 1.54 HIV protease (PR) dimer with acetate in exo site and peptide in active site
2O4S 2006-12-12 1.54 Crystal Structure of HIV-1 Protease (Q7K) in Complex with Lopinavir
4J54 2013-05-15 1.55 Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical isolate PR20 with the potent antiviral inhibitor GRL-0519A
4CPS 2014-12-17 1.55 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
3TKW 2012-04-25 1.55 Crystal structure of HIV protease model precursor/Darunavir complex
2PQZ 2008-04-15 1.55 HIV-1 Protease in complex with a pyrrolidine-based inhibitor
5AH7 2015-02-18 1.55 Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
3K0O 2009-12-08 1.55 Room temperature structure of CypA mutant Ser99Thr
1K1U 2002-07-10 1.55 Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
1DAZ 2000-05-03 1.55 Structural and kinetic analysis of drug resistant mutants of HIV-1 protease
3ZPS 2013-11-06 1.55 Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors
3VFB 2012-11-21 1.55 Crystal Structure of HIV-1 Protease Mutant N88D with novel P1'-Ligands GRL-02031
5NMH 2017-11-15 1.55 HLA A02 presenting SLYNTIATL
4MC2 2014-04-02 1.56 HIV protease in complex with SA525P
1AWQ 1998-03-18 1.58 CYPA COMPLEXED WITH HAGPIA (PSEUDO-SYMMETRIC MONOMER)
2R43 2008-09-09 1.58 I50V HIV-1 protease in complex with an amino decorated pyrrolidine-based inhibitor
1AWR 1998-03-18 1.58 CYPA COMPLEXED WITH HAGPIA
4YUN 2015-10-14 1.58 Multiconformer synchrotron model of CypA at 310 K
3QRS 2012-02-22 1.59 HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor
4U1H 2015-04-08 1.59 HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential HIV-1 escape through identical epitopes
4COC 2014-06-04 1.59 HIV-1 capsid C-terminal domain mutant (Y169L)
6GJI 2018-11-07 1.6 Cyclophilin A complexed with the tri-vector ligand 8.
6B3C 2018-01-03 1.6 Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,6R)-6-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide
3EL9 2009-09-01 1.6 Crystal structure of atazanavir (ATV) in complex with a multidrug HIV-1 protease (V82T/I84V)
1YND 2005-04-05 1.6 Structure of human cyclophilin A in complex with the novel immunosuppressant sanglifehrin A at 1.6A resolution
4G9D 2013-03-20 1.6 Crystal Structure of HLA B2705-KK10
3EL5 2009-09-01 1.6 Crystal structure of nelfinavir (NFV) complexed with a multidrug variant (ACT) (V82T/I84V) of HIV-1 protease
5NOQ 2017-07-12 1.6 Structure of cyclophilin A in complex with 3-chloropyridin-2-amine
3DS0 2008-09-02 1.6 HIV-1 capsid C-terminal domain mutant (N183A) in complex with an inhibitor of particle assembly (CAI)
1EXQ 2000-11-03 1.6 CRYSTAL STRUCTURE OF THE HIV-1 INTEGRASE CATALYTIC CORE DOMAIN
3OUB 2011-03-30 1.6 MDR769 HIV-1 protease complexed with NC/p1 hepta-peptide
4G8I 2013-03-20 1.6 Crystal Structure of HLA B2705-KK10-L6M
3BXS 2008-03-25 1.6 Crystal Structures Of Highly Constrained Substrate And Hydrolysis Products Bound To HIV-1 Protease. Implications For Catalytic Mechanism
3HLO 2011-07-27 1.6 Crystal structure of chemically synthesized 'covalent dimer' [Gly51/D-Ala51']HIV-1 protease
3BXR 2008-03-25 1.6 Crystal Structures Of Highly Constrained Substrate And Hydrolysis Products Bound To HIV-1 Protease. Implications For Catalytic Mechanism
3DS1 2008-09-02 1.6 HIV-1 capsid C-terminal domain mutant (E187A) in complex with an inhibitor of particle assembly (CAI)
3FSM 2010-01-05 1.6 CRYSTAL STRUCTURE OF A CHEMICALLY SYNTHESIZED 203 AMINO ACID 'COVALENT DIMER' [L-Ala51,D-Ala51'] HIV-1 PROTEASE MOLECULE
3EKW 2009-09-01 1.6 Crystal structure of the inhibitor Atazanavir (ATV) in complex with a multi-drug resistance HIV-1 protease variant (L10I/G48V/I54V/V64I/V82A) Refer: FLAP+ in citation.
3OU4 2011-03-30 1.6 MDR769 HIV-1 protease complexed with TF/PR hepta-peptide
2AOJ 2006-01-17 1.6 Crystal structure analysis of HIV-1 protease with a substrate analog P6-PR
2Z4O 2008-04-22 1.6 Wild Type HIV-1 Protease with potent Antiviral inhibitor GRL-98065
2O4K 2006-12-12 1.6 Crystal Structure of HIV-1 Protease (Q7K) in Complex with Atazanavir
3JVY 2009-12-08 1.6 HIV-1 Protease Mutant G86A with DARUNAVIR
3IAW 2011-04-27 1.61 Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution
3QPJ 2012-02-15 1.61 HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor
5NOZ 2017-07-12 1.61 Structure of cyclophilin A in complex with 3,4-diaminobenzohydrazide
6C8X 2018-12-05 1.61 Wild-type HIV-1 protease in complex with a phenylboronic acid (P2') analog of darunavir
6B3H 2018-01-03 1.62 Crystal Structure of HIV Protease complexed with N-(2-(2-((6R,9S)-2,2-dioxido-2-thia-1,7-diazabicyclo[4.3.1]decan-9-yl)ethyl)-3-fluorophenyl)-3,3-bis(4-fluorophenyl)propanamide
5DGW 2015-10-28 1.62 Crystal Structure of HIV-1 Protease Inhibitor GRL-105-11A Containing Substituted fused-Tetrahydropyranyl Tetrahydrofuran as P2-Ligand
3QRO 2012-02-22 1.62 HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor
6B36 2018-01-03 1.63 Crystal Structure of HIV Protease complexed with (S)-N-(3-fluoro-2-(2-(1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide
2CPL 1993-10-31 1.63 SIMILARITIES AND DIFFERENCES BETWEEN HUMAN CYCLOPHILIN A AND OTHER BETA-BARREL STRUCTURES. STRUCTURAL REFINEMENT AT 1.63 ANGSTROMS RESOLUTION
3UF3 2012-03-28 1.63 Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical isolate PR20
2CYH 1996-07-11 1.64 CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE ALA-PRO
4IPY 2013-10-16 1.64 HIV capsid C-terminal domain
3CKT 2009-03-24 1.65 HIV-1 protease in complex with a dimethylallyl decorated pyrrolidine based inhibitor (orthorombic space group)
1ZPK 2006-04-25 1.65 Crystal structure of the complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
2ZGA 2009-02-03 1.65 HIV-1 protease in complex with a dimethylallyl decorated pyrrolidine based inhibitor (hexagonal space group)
5UFZ 2018-01-10 1.65 HIV-1 Protease complexed with Inhibitor: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2S)-1-(1-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}cyclopropyl)-1-hydroxy-3-phenylpropan-2-yl]carbamate
2XXM 2011-10-12 1.65 Crystal structure of the HIV-1 capsid protein C-terminal domain in complex with a camelid VHH and the CAI peptide.
3O9G 2011-08-10 1.65 Crystal Structure of wild-type HIV-1 Protease in complex with af53
4CF8 2013-12-11 1.65 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3OXX 2011-09-28 1.65 Crystal Structure of HIV-1 I50V, A71V Protease in Complex with the Protease Inhibitor Atazanavir
2NPH 2006-12-19 1.65 Crystal structure of HIV1 protease in situ product complex
1W8M 2004-09-30 1.65 Enzymatic and Structural Characterisation of Non Peptide Ligand Cyclophilin Complexes
3KT2 2010-02-16 1.65 Crystal Structure of N88D mutant HIV-1 Protease
4N1Q 2015-08-12 1.65 Structure of Cyclophilin A in complex with cyclohexanecarboxamide.
3K0P 2009-12-08 1.65 Cryogenic structure of CypA mutant Ser99Thr
4OBK 2014-11-26 1.65 Crystal structure of inactive HIV-1 protease in complex with the P1-P6 substrate variant (L449F/S451N)
5KRT 2016-09-28 1.65 HIV-1 Integrase Catalytic Core Domain (CCD) in Complex with a Fragment-Derived Allosteric Inhibitor
3KDB 2010-03-02 1.66 Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10006
5NMK 2017-11-15 1.66 HLA A02 presenting SLFNTIAVL
6BZ2 2018-02-28 1.67 Crystal structure of wild-type HIV-1 protease with a novel HIV-1 inhibitor GRL-14213A of 6-5-5-ring fused crown-like tetrahydropyranofuran as the P2-ligand, a cyclopropylaminobenzothiazole as the P2'-ligand and 3,5-difluorophenylmethyl as the P1-ligand
4QJ7 2014-10-29 1.67 Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with p1-p6 substrate variant (R452S)
4IPZ 2013-11-06 1.67 SmBz bound to Cyclophilin A
4OBF 2014-11-26 1.68 Crystal Structure of Nelfinavir-Resistant, Inactive HIV-1 Protease Variant (D30N/N88D) in Complex with the p1-p6 substrate variant (S451N)
4EPJ 2012-06-06 1.69 Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate p2-NC
6GJR 2018-11-07 1.69 Cyclophilin A complexed with tri-vector ligand 9.
2WHH 2009-12-01 1.69 HIV-1 protease tethered dimer Q-product complex along with nucleophilic water molecule
1DIF 1996-03-08 1.7 HIV-1 PROTEASE IN COMPLEX WITH A DIFLUOROKETONE CONTAINING INHIBITOR A79285
3ZSR 2012-07-11 1.7 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
5KV1 2016-08-10 1.7 Human cyclophilin A at 278K, Data set 3
5KUV 2016-08-10 1.7 Human cyclophilin A at 100K, Data set 8
2BBB 2005-11-15 1.7 Structure of HIV1 protease and hh1_173_3a complex.
2WKZ 2009-12-15 1.7 HIV-1 Protease Inhibitors Containing a Tertiary Alcohol in the Transition-State Mimic with Improved Cell-Based Antiviral Activity
1K2B 2002-07-10 1.7 Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
3QIN 2011-04-20 1.7 Crystal Structure of HIV-1 RNase H p15 with engineered E. coli loop and pyrimidinol carboxylic acid inhibitor
5KV0 2016-08-31 1.7 Human cyclophilin A at 278K, Data set 2
3I7E 2009-09-29 1.7 Co-crystal structure of HIV-1 protease bound to a mutant resistant inhibitor UIC-98038
5KUL 2016-09-07 1.7 Human cyclophilin A at 100K, Data set 1
5KV3 2016-08-10 1.7 Human cyclophilin A at 278K, Data set 5
1B9F 1999-07-19 1.7 MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY
5KRS 2016-09-28 1.7 HIV-1 Integrase Catalytic Core Domain in Complex with an Allosteric Inhibitor, 3-(1H-pyrrol-1-yl)-2-thiophenecarboxylic acid
5XOS 2017-06-14 1.7 Crystal structure of HLA-B35 in complex with a pepetide antigen
5KV4 2016-08-10 1.7 Human cyclophilin A at 278K, Data set 6
5KV6 2016-08-10 1.7 Human cyclophilin A at 278K, Data set 8
5KUS 2016-08-10 1.7 Human cyclophilin A at 100K, Data set 6
4CIE 2014-01-08 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4CEZ 2013-11-27 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3AVG 2012-01-18 1.7 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
3OTS 2011-03-30 1.7 MDR769 HIV-1 protease complexed with MA/CA hepta-peptide
4CEQ 2013-11-20 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4E91 2012-04-25 1.7 Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BD3
5KUW 2016-08-10 1.7 Human cyclophilin A at 100K, Data set 9
5KV7 2016-08-31 1.7 Human cyclophilin A at 278K, Data set 9
5KV2 2016-08-10 1.7 Human cyclophilin A at 278K, Data set 4
4CPT 2014-12-17 1.7 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
2BUO 2005-07-21 1.7 HIV-1 capsid C-terminal domain in complex with an inhibitor of particle assembly
4CJ3 2014-01-08 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3ZT2 2012-07-11 1.7 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
3WNE 2013-12-25 1.7 Cyclic hexapeptide PKIDNG in complex with HIV-1 integrase
1HYV 2001-04-04 1.7 HIV INTEGRASE CORE DOMAIN COMPLEXED WITH TETRAPHENYL ARSONIUM
4DGB 2012-02-08 1.7 TRIMCyp cyclophilin domain from Macaca mulatta: HIV-2 CA cyclophilin-binding loop complex
4U7Q 2015-03-25 1.7 Structure of wild-type HIV protease in complex with photosensitive inhibitor PDI-6
4CGF 2013-12-04 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
5KUO 2016-08-31 1.7 Human cyclophilin A at 100K, Data set 3
5JPA 2016-08-10 1.7 Hexameric HIV-1 CA H12Y mutant
3AVA 2012-01-18 1.7 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
4CHY 2013-12-18 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3OUA 2011-03-30 1.7 MDR769 HIV-1 protease complexed with p1/p6 hepta-peptide
3AVJ 2012-01-18 1.7 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
4CER 2013-11-20 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4OVL 2014-03-05 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
5KUZ 2016-08-10 1.7 Human cyclophilin A at 278K, Data set 1
3NLS 2011-09-07 1.7 Crystal Structure of HIV-1 Protease in Complex with KNI-10772
1M9X 2003-05-27 1.7 X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,A88M,G89A Complex.
3IXO 2010-03-02 1.7 Crystal Structure of uncomplexed HIV_1 Protease Subtype A
3I8W 2009-12-01 1.7 Crystal structure of a metallacarborane inhibitor bound to HIV protease
3O9H 2011-08-10 1.7 Crystal Structure of wild-type HIV-1 Protease in complex with kd26
3AVI 2012-02-15 1.7 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
3ZSQ 2012-07-11 1.7 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
5JFU 2016-09-21 1.7 HIV-1 wild Type protease with GRL-007-14A (a Adamantane P1-Ligand with bis-THF in P2 and benzylamine in P1')
5KUN 2016-08-10 1.7 Human cyclophilin A at 100K, Data set 2
4CIG 2014-01-08 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4CJQ 2014-01-08 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4CJU 2014-01-22 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
5KUR 2016-09-07 1.7 Human cyclophilin A at 100K, Data set 5
4CHO 2013-12-11 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4CEF 2013-11-20 1.7 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3EL1 2009-09-01 1.7 Crystal Structure of wild-type HIV protease in complex with the inhibitor, Atazanavir
6GJN 2018-11-07 1.7 Cyclophilin A complexed with tri-vector ligand 15.
5KV5 2016-08-10 1.7 Human cyclophilin A at 278K, Data set 7
1B9D 1999-07-19 1.7 MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY
4AH9 2012-12-19 1.7 Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification
5KUQ 2016-08-10 1.7 Human cyclophilin A at 100K, Data set 4
1A8O 1998-10-14 1.7 HIV CAPSID C-TERMINAL DOMAIN
5KUU 2016-08-31 1.7 Human cyclophilin A at 100K, Data set 7
4F75 2013-05-15 1.7 Crystal Structure of active HIV-1 Protease in Complex with the N terminal product of the substrate RH-IN
1FFI 2001-06-01 1.7 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
3OU3 2011-03-30 1.7 MDR769 HIV-1 protease complexed with PR/RT hepta-peptide
4EQ0 2012-06-06 1.7 Crystal Structure of inactive single chain variant of HIV-1 Protease in Complex with the substrate p2-NC
3O9F 2011-08-10 1.7 Crystal Structure of wild-type HIV-1 Protease in complex with kd27
3AVF 2012-01-18 1.7 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
1W8V 2004-09-30 1.7 Enzymatic and structural characterization of non peptide ligand cyclophilin complexes
4CPW 2014-12-17 1.7 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
3AV9 2012-01-18 1.7 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
3HBO 2010-05-26 1.71 Crystal structure of chemically synthesized [D-Ala51/51']HIV-1 protease
4CJT 2014-01-08 1.71 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4QAG 2014-06-04 1.71 Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNASE H domain of HIV-1 reverse transcriptase
3OQD 2011-04-06 1.71 Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants
3OQ7 2011-04-06 1.71 Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants
1M9E 2003-05-27 1.72 X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A Complex.
3NDT 2011-07-20 1.72 HIV-1 Protease Saquinavir:Ritonavir 1:1 complex structure
1M9F 2003-05-27 1.73 X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,A88M Complex.
3QRM 2012-02-22 1.73 HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor
1XL5 2005-06-07 1.73 HIV-1 Protease in complex with amidhyroxysulfone
4CEC 2013-11-20 1.75 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4CK1 2014-01-22 1.75 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3EKV 2009-09-01 1.75 Crystal structure of the wild type HIV-1 protease with the inhibitor, Amprenavir
3OXV 2011-09-28 1.75 Crystal Structure of HIV-1 I50V, A71 Protease in Complex with the protease inhibitor amprenavir.
1MTR 1996-08-01 1.75 HIV-1 PROTEASE COMPLEXED WITH A CYCLIC PHE-ILE-VAL PEPTIDOMIMETIC INHIBITOR
4CGG 2013-12-04 1.75 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4CED 2013-11-20 1.75 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4I8Z 2013-07-24 1.75 Crystal structure of wild type HIV-1 protease in complex with non-peptidic inhibitor, GRL008
3OTY 2011-03-30 1.75 MDR769 HIV-1 protease complexed with RT/RH hepta-peptide
4OBJ 2014-11-26 1.75 Crystal Structure of Inactive HIV-1 Protease in Complex with the p1-p6 substrate variant (S451N)
4CEB 2013-11-20 1.75 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3ZT1 2012-07-11 1.75 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
5HRN 2016-12-14 1.75 HIV Integrase Catalytic Domain containing F185K mutation complexed with GSK0002
3ZSO 2012-07-11 1.75 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based design
1B6L 2000-01-07 1.75 HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 4
4AHS 2012-12-19 1.75 Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification
3AVK 2012-01-18 1.75 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
2UXZ 2008-05-20 1.75 Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary- Alcohol-Containing Transition-State Mimic
3ZSV 2012-07-11 1.75 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
6DJ5 2018-10-17 1.75 HIV-1 protease with mutation L76V in complex with GRL-0519 (tris-tetrahydrofuran as P2 ligand)
3BHE 2008-12-09 1.75 HIV-1 protease in complex with a three armed pyrrolidine derivative
3WNG 2013-12-25 1.75 Cyclic hexapeptide PKIDNp in complex with HIV-1 integrase
4YUP 2015-10-14 1.75 Multiconformer fixed-target X-ray free electron (XFEL) model of CypA at 273 K
4CJK 2014-01-08 1.75 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1D4L 2000-10-11 1.75 HIV-1 PROTEASE COMPLEXED WITH A MACROCYCLIC PEPTIDOMIMETIC INHIBITOR
4N1O 2015-08-12 1.75 Structure of Cyclophilin A in complex with Saccharin.
3LZU 2010-08-11 1.76 Crystal Structure of a Nelfinavir Resistant HIV-1 CRF01_AE Protease variant (N88S) in Complex with the Protease Inhibitor Darunavir.
4CGH 2013-12-04 1.76 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1MIK 1996-03-08 1.76 THE ROLE OF WATER MOLECULES IN THE STRUCTURE-BASED DESIGN OF (5-HYDROXYNORVALINE)-2-CYCLOSPORIN: SYNTHESIS, BIOLOGICAL ACTIVITY, AND CRYSTALLOGRAPHIC ANALYSIS WITH CYCLOPHILIN A
2UY0 2008-05-20 1.76 Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary- Alcohol-Containing Transition-State Mimic
5JL4 2017-10-04 1.76 Inhibitor resistant mutant catalytic core domain of HIV-1 Integrase
3OY4 2011-02-09 1.76 Crystal Structure of HIV-1 L76V Protease in Complex with the Protease Inhibitor Darunavir.
5YRS 2018-03-07 1.76 X-ray Snapshot of HIV-1 Protease in Action: Observation of Tetrahedral Intermediate and Its SIHB with Catalytic Aspartate
4CJL 2014-01-08 1.77 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4U0C 2014-11-12 1.77 Hexameric HIV-1 CA in complex with Nup153 peptide, P6 crystal form
3KFP 2010-02-23 1.77 HIV Protease (PR) with inhibitor TL-3 bound, and DMSOs in exo site
3KFN 2010-02-23 1.77 HIV Protease (PR) with inhibitor TL-3 and fragment hit 4D9 by soaking
3AVC 2012-01-18 1.77 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
1FEJ 2001-06-01 1.78 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
2PWC 2008-04-15 1.78 HIV-1 protease in complex with a amino decorated pyrrolidine-based inhibitor
4OBG 2014-11-26 1.78 Crystal Structure of Nelfinavir-Resistant, Inactive HIV-1 Protease (D30N/N88D) in Complex with the p1-p6 substrate.
4DQH 2012-03-07 1.79 Crystal Structure of (R14C/E65C) HIV-1 Protease in complex with DRV
4CK3 2014-01-22 1.79 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4EJK 2013-05-01 1.79 HIV Protease (PR) dimer in closed form with pepstatin in active site and fragment 1F1-N in the outside/top of flap
1EC0 2002-06-26 1.79 HIV-1 protease in complex with the inhibitor bea403
4GB2 2013-07-31 1.79 HIV-1 protease (mutant Q7K L33I L63I) in complex with a bicyclic pyrrolidine inhibitor
4Q5M 2015-04-08 1.79 D30N tethered HIV-1 protease dimer/saquinavir complex
1HVL 1994-04-30 1.8 INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE
1PRO 1996-08-17 1.8 HIV-1 PROTEASE DIMER COMPLEXED WITH A-98881
1HVR 1995-01-26 1.8 RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS
3ZCM 2012-12-05 1.8 Small molecule inhibitors of the LEDGF site of HIV integrase identified by fragment screening and structure based design.
4CP7 2014-12-10 1.8 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
1W5W 2004-12-22 1.8 HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor
3KDD 2010-03-02 1.8 Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10265
5KAO 2016-08-31 1.8 Crystal structure of wild type HIV-1 protease in complex with GRL-10413
2QI4 2008-04-22 1.8 Crystal structure of protease inhibitor, MIT-2-AD93 in complex with wild type HIV-1 protease
1HWR 1999-03-23 1.8 MOLECULAR RECOGNITION OF CYCLIC UREA HIV PROTEASE INHIBITORS
4A6B 2012-05-09 1.8 Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based HIV-1 Protease Inhibitors
3KT5 2010-02-16 1.8 Crystal Structure of N88S mutant HIV-1 Protease
4CEE 2013-11-27 1.8 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1HVK 1994-04-30 1.8 INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE
1W5V 2004-12-01 1.8 HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor
4N1R 2015-08-12 1.8 Structure of Cyclophilin A in complex with benzenesulfonohydrazide.
6AOC 2018-08-08 1.8 Crystal Structure of an N-Hydroxythienopyrimidine-2,4-dione RNase H Active Site Inhibitor with Multiple Binding Modes to HIV Reverse Transcriptase
2FXE 2007-02-20 1.8 X-ray crystal structure of HIV-1 protease CRM mutant complexed with atazanavir (BMS-232632)
2R3T 2008-09-02 1.8 I50V HIV-1 protease mutant in complex with a carbamoyl decorated pyrrolidine-based inhibitor
3GI5 2010-03-09 1.8 Crystal structure of protease inhibitor, KB62 in complex with wild type HIV-1 protease
3OUD 2011-03-30 1.8 MDR769 HIV-1 protease complexed with CA/p2 hepta-peptide
4ICL 2013-02-06 1.8 HIV-1 reverse transcriptase with bound fragment at the incoming dNTP binding site
1CWK 1998-07-15 1.8 HUMAN CYCLOPHILIN A COMPLEXED WITH 1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORIN
3GGU 2009-08-11 1.8 HIV PR drug resistant patient's variant in complex with darunavir
3ZPU 2013-11-06 1.8 Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors
1HVH 1998-12-30 1.8 NONPEPTIDE CYCLIC CYANOGUANIDINES AS HIV PROTEASE INHIBITORS
1BCK 1998-09-16 1.8 HUMAN CYCLOPHILIN A COMPLEXED WITH 2-THR CYCLOSPORIN
1EC3 2002-06-26 1.8 HIV-1 protease in complex with the inhibitor MSA367
1QBR 1997-10-15 1.8 HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
4J5J 2013-05-15 1.8 Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Amprenavir
2XGY 2010-09-22 1.8 Complex of Rabbit Endogenous Lentivirus (RELIK)Capsid with Cyclophilin A
4AHV 2012-12-19 1.8 Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification
4LH4 2013-12-25 1.8 Dual inhibition of HIV-1 replication by Integrase-LEDGF allosteric inhibitors is predominant at post-integration stage during virus production rather than at integration
4CIF 2014-01-08 1.8 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4K4Q 2013-09-18 1.8 TL-3 inhibited Trp6Ala HIV Protease with 3-bromo-2,6-dimethoxybenzoic acid bound in flap site
3OU1 2011-03-30 1.8 MDR769 HIV-1 protease complexed with RH/IN hepta-peptide
2XYF 2011-12-07 1.8 HIV-1 Inhibitors with a Tertiary-Alcohol-containing Transition-State Mimic and various P2 and P1 prime Substituents
4CEA 2013-11-20 1.8 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4CPR 2014-12-17 1.8 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
3NXN 2011-11-02 1.8 X-ray structure of ester chemical analogue 'covalent dimer' [Ile50,O-Ile50']HIV-1 protease complexed with KVS-1 inhibitor
4CJ4 2014-01-08 1.8 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4EQJ 2012-06-06 1.8 Crystal Structure of inactive single chain variant of HIV-1 Protease in Complex with the substrate RT-RH
3NF7 2011-04-27 1.8 Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design
3GI0 2011-08-10 1.8 Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [l-ala51,d-ala51'] hiv-1 protease molecule complexed with jg-365 inhibitor
3AO2 2011-03-16 1.8 Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase
4CJS 2014-01-08 1.8 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1BWB 1998-09-30 1.8 HIV-1 PROTEASE (V82F/I84V) DOUBLE MUTANT COMPLEXED WITH SD146 OF DUPONT PHARMACEUTICALS
4CHZ 2013-12-18 1.8 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3KF0 2010-02-23 1.8 HIV Protease with fragment 4D9 bound
4E92 2012-04-25 1.8 Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BM4
4AHT 2012-12-19 1.8 Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification
3JVW 2009-12-08 1.8 HIV-1 Protease Mutant G86A with symmetric inhibitor DMP323
1FGL 1997-04-01 1.8 Cyclophilin A complexed with a fragment of HIV-1 GAG protein
1G35 2001-06-06 1.8 CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR, AHA024
4K4R 2013-09-18 1.8 TL-3 inhibited Trp6Ala HIV Protease with 1-bromo-2-napthoic acid bound in exosite
1FG6 2001-06-01 1.8 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
3ZSW 2012-07-11 1.8 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
3BGC 2008-09-02 1.8 HIV-1 protease in complex with a benzyl decorated oligoamine
3KFS 2010-02-23 1.8 HIV Protease (PR) dimer with inhibitor TL-3 bound and fragment 2F4 in the outside/top of flap
1SP5 2005-07-19 1.8 Crystal structure of HIV-1 protease complexed with a product of autoproteolysis
3HDK 2010-04-28 1.8 Crystal structure of chemically synthesized [Aib51/51']HIV-1 protease
1QBS 1997-10-15 1.8 HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
1QBU 1997-10-15 1.8 HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
3EKY 2009-09-01 1.8 Crystal Structure of wild-type HIV protease in complex with the inhibitor, Atazanavir
1W8L 2004-09-30 1.8 Enzymatic and structural characterization of non peptide ligand cyclophilin complexes
1CWL 1998-07-15 1.8 HUMAN CYCLOPHILIN A COMPLEXED WITH 4 4-HYDROXY-MELEU CYCLOSPORIN
1HXW 1998-02-04 1.8 HIV-1 PROTEASE DIMER COMPLEXED WITH A-84538
1CWJ 1998-08-26 1.8 HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL 3-S-METHYL-SARCOSINE CYCLOSPORIN
5NOR 2017-07-12 1.8 Structure of cyclophilin A in complex with 3-methylpyridin-2-amine
3JW2 2009-12-08 1.8 HIV-1 Protease Mutant G86S with DARUNAVIR
4CJR 2014-01-08 1.8 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
5VCK 2018-04-18 1.8 HIV Protease (PR) with TL-3 in the active site and (Z)-N-(thiazol-2-yl)-N'-tosylcarbamimidate in the exosite
2ZD1 2008-02-12 1.8 Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with TMC278 (Rilpivirine), A Non-nucleoside RT Inhibitor
1D4I 2002-06-26 1.81 HIV-1 protease in complex with the inhibitor BEA425
5HRP 2016-12-14 1.81 HIV Integrase Catalytic Domain containing F185K + A124T mutations complexed with GSK0002
1D4H 2002-06-26 1.81 HIV-1 Protease in complex with the inhibitor BEA435
4EP3 2012-06-06 1.81 Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate CA-p2
1EBW 2002-06-26 1.81 HIV-1 protease in complex with the inhibitor BEA322
2R38 2008-09-02 1.81 I84V HIV-1 protease mutant in complex with a carbamoyl decorated pyrrolidine-based inhibitor
1D4J 2002-06-26 1.81 HIV-1 protease in complex with the inhibitor MSL370
3BC4 2008-09-02 1.82 I84V HIV-1 protease in complex with a pyrrolidine diester
4CPU 2014-12-17 1.82 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
4OJR 2014-06-11 1.82 Crystal Structure of the HIV-1 Integrase catalytic domain with GSK1264
4QJ9 2014-10-29 1.83 Crystal structure of inactive HIV-1 protease in complex with p1-p6 substrate variant (R452S)
1IIQ 2002-04-12 1.83 CRYSTAL STRUCTURE OF HIV-1 PROTEASE COMPLEXED WITH A HYDROXYETHYLAMINE PEPTIDOMIMETIC INHIBITOR
3GI6 2010-03-09 1.84 Crystal structure of protease inhibitor, AD78 in complex with wild type HIV-1 protease
5TC2 2018-04-04 1.84 C-terminal domain of HIV-1 integrase, crystal structure
3GI4 2010-03-09 1.85 Crystal structure of protease inhibitor, KB60 in complex with wild type HIV-1 protease
1FF0 2001-06-01 1.85 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES.
1Z1H 2005-03-22 1.85 HIV-1 protease complexed with macrocyclic peptidomimetic inhibitor 3
3DLK 2008-10-07 1.85 Crystal Structure of an engineered form of the HIV-1 Reverse Transcriptase, RT69A
2QI7 2008-04-22 1.85 Crystal structure of protease inhibitor, MIT-2-AD86 in complex with wild type HIV-1 protease
4COP 2014-06-04 1.85 HIV-1 capsid C-terminal domain mutant (Y169S)
6D0D 2019-05-01 1.85 X-ray crystal structure of wild type HIV-1 protease in complex with GRL-087-13
2QHY 2008-04-22 1.85 Crystal Structure of protease inhibitor, MIT-1-AC86 in complex with wild type HIV-1 protease
4CF0 2013-11-20 1.85 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
2QHZ 2008-04-22 1.85 Crystal structure of protease inhibitor, MIT-1-AC87 in complex with wild type HIV-1 protease
1B6J 2000-01-07 1.85 HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 1
2PYN 2008-02-26 1.85 HIV-1 PR mutant in complex with nelfinavir
4CPX 2014-12-17 1.85 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
4CK2 2014-01-22 1.85 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1Z1R 2005-03-22 1.85 HIV-1 protease complexed with Macrocyclic peptidomimetic inhibitor 2
1D4K 2000-10-11 1.85 HIV-1 PROTEASE COMPLEXED WITH A MACROCYCLIC PEPTIDOMIMETIC INHIBITOR
2QI5 2008-04-22 1.85 Crystal structure of protease inhibitor, MIT-2-KC08 in complex with wild type HIV-1 protease
4KFB 2013-05-15 1.85 HIV-1 reverse transcriptase with bound fragment at NNRTI adjacent site
3NU9 2010-08-25 1.85 Crystal Structure of HIV-1 Protease Mutant I84V with Antiviral Drug Amprenavir
4OBH 2014-11-26 1.85 Crystal Structure of Inactive HIV-1 Protease in Complex with the p1-p6 substrate variant (L449F)
4CES 2013-11-20 1.85 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
2QI6 2008-04-22 1.85 Crystal structure of protease inhibitor, MIT-2-KB98 in complex with wild type HIV-1 protease
1B6M 2000-01-07 1.85 HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 6
4Q1W 2015-02-18 1.85 Mutations Outside the Active Site of HIV-1 Protease Alter Enzyme Structure and Dynamic Ensemble of the Active Site to Confer Drug Resistance
2FNS 2006-09-05 1.85 Crystal structure of wild-type inactive (D25N) HIV-1 protease complexed with wild-type HIV-1 NC-p1 substrate.
4F76 2013-05-15 1.85 Crystal Structure of the active HIV-1 Protease in Complex with the products of p1-p6 substrate
3AVB 2012-01-18 1.85 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
1B6K 2000-01-07 1.85 HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 5
1FG8 2001-06-01 1.85 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
3MXE 2010-11-10 1.85 Crystal structure of HIV-1 protease inhibitor, KC32 complexed with wild-type protease
1CWH 1998-07-15 1.86 HUMAN CYCLOPHILIN A COMPLEXED WITH 3-D-SER CYCLOSPORIN
1CWF 1998-07-15 1.86 HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL CYCLOSPORIN
1CWO 1998-08-12 1.86 HUMAN CYCLOPHILIN A COMPLEXED WITH THR2, LEU5, D-HIV8, LEU10 CYCLOSPORIN
1CWC 1996-01-29 1.86 IMPROVED BINDING AFFINITY FOR CYCLOPHILIN A BY A CYCLOSPORIN DERIVATIVE SINGLY MODIFIED AT ITS EFFECTOR DOMAIN
5HRS 2016-12-14 1.86 HIV Integrase Catalytic Domain containing F185K + A124N + T125A mutations complexed with GSK0002
4ID1 2013-05-01 1.87 HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor
5HRR 2016-12-14 1.88 HIV Integrase Catalytic Domain containing F185K + A124N + T125S mutations complexed with GSK0002
3AVH 2012-01-18 1.88 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
3AVM 2012-01-18 1.88 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
1DW6 2000-07-26 1.88 Structural and kinetic analysis of drug resistant mutants of HIV-1 protease
3AVL 2012-01-18 1.88 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
2XV6 2011-10-12 1.89 Crystal structure of the HIV-1 capsid protein C-terminal domain (146- 220) in complex with a camelid VHH.
4F73 2013-05-15 1.9 Crystal Structure of active HIV-1 Protease in Complex with the N terminal product of CA-p2 cleavage site
2BPV 1999-02-23 1.9 HIV-1 protease-inhibitor complex
2ZYE 2009-03-24 1.9 Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by Neutron Crystallography
1HPV 1995-03-31 1.9 CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH VX-478, A POTENT AND ORALLY BIOAVAILABLE INHIBITOR OF THE ENZYME
2PWM 2007-09-25 1.9 Crystal Structure of HIV-1 CA146 A92E real cell
3R4B 2011-09-21 1.9 Crystal Structure of Wild-type HIV-1 Protease in Complex With TMC310911
4DQF 2012-03-07 1.9 Crystal Structure of (G16A/L38A) HIV-1 Protease in Complex with DRV
4CEO 2013-11-20 1.9 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1G6L 2000-11-15 1.9 1.9A CRYSTAL STRUCTURE OF TETHERED HIV-1 PROTEASE
1MT7 2003-01-07 1.9 Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
4OBD 2014-11-26 1.9 Crystal Structure of Nelfinavir-Resistant, Inactive HIV-1 Protease (D30N/N88D) in Complex with the p1-p6 substrate variant (L449F/S451N)
1MES 1998-04-15 1.9 HIV-1 MUTANT (I84V) PROTEASE COMPLEXED WITH DMP323
4DGA 2012-02-08 1.9 TRIMCyp cyclophilin domain from Macaca mulatta: HIV-1 CA(O-loop) complex
2GON 2006-09-26 1.9 Xray Structure of Gag133-278
1MEU 1998-04-15 1.9 HIV-1 MUTANT (V82F, I84V) PROTEASE COMPLEXED WITH DMP323
4G9F 2013-03-20 1.9 Crystal Structure of C12C TCR-HLAB2705-KK10-L6M
1FGC 2001-06-01 1.9 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
1SGU 2004-10-05 1.9 Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease
2WL0 2009-12-15 1.9 HIV-1 Protease Inhibitors Containing a Tertiary Alcohol in the Transition-State Mimic with Improved Cell-Based Antiviral Activity
3BGB 2008-09-02 1.9 HIV-1 protease in complex with a isobutyl decorated oligoamine
4CHP 2013-12-11 1.9 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4CFC 2013-11-27 1.9 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
2BPY 1999-02-23 1.9 HIV-1 protease-inhibitor complex
3MGE 2010-07-21 1.9 X-ray Structure of Hexameric HIV-1 CA
4CJF 2014-01-08 1.9 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
2PYM 2008-02-26 1.9 HIV-1 PR mutant in complex with nelfinavir
4Q1X 2015-02-18 1.9 Mutations Outside the Active Site of HIV-1 Protease Alter Enzyme Structure and Dynamic Ensemble of the Active Site to Confer Drug Resistance
1BWA 1998-10-30 1.9 HIV-1 PROTEASE (V82F/I84V) DOUBLE MUTANT COMPLEXED WITH XV638 OF DUPONT PHARMACEUTICALS
6ES8 2018-08-15 1.9 HIV capsid hexamer with IP6 ligand
4N1P 2015-08-12 1.9 Structure of Cyclophilin A in complex with Picolinamide.
4NYF 2014-06-25 1.9 HIV integrase in complex with inhibitor
6BJ3 2018-07-25 1.9 TCR55 in complex with HIV(Pol448-456)/HLA-B35
6C0O 2018-08-01 1.9 Crystal structure of HIV-1 K103N mutant reverse transcriptase in complex with non-nucleoside inhibitor 25a
1M9Y 2003-05-27 1.9 X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,G89A Complex.
1FFF 2001-06-01 1.9 STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE : HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES.
4QGI 2014-07-16 1.9 X-ray crystal structure of HIV-1 protease variant G48T/L89M in complex with Saquinavir
4CJE 2014-01-08 1.9 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4E1M 2012-04-25 1.9 Crystal Structure of HIV-1 Integrase with a non-catayltic site inhibitor
1MET 1998-04-15 1.9 HIV-1 MUTANT (V82F) PROTEASE COMPLEXED WITH DMP323
1MER 1998-04-15 1.9 HIV-1 MUTANT (I84V) PROTEASE COMPLEXED WITH DMP450
5HGN 2016-08-10 1.9 Hexameric HIV-1 CA, apo form
3CYH 1996-07-11 1.9 CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE SER-PRO
4AHU 2012-12-19 1.9 Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification
3NWX 2011-11-02 1.9 X-ray structure of ester chemical analogue [O-Ile50,O-Ile50']HIV-1 protease complexed with KVS-1 inhibitor
1W5X 2004-12-22 1.9 HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor
1M9D 2003-05-27 1.9 X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) O-type chimera Complex.
3NF8 2011-04-27 1.9 Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design
1CWI 1998-08-12 1.9 HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL 3-(N-METHYL)-D-ALANINE CYCLOSPORIN
5TSX 2017-11-08 1.9 HIV-1 CA hexamer with NUP153 peptide - P1 crystal form
4EP2 2012-06-06 1.9 Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate RT-RH
4AHR 2012-12-19 1.9 Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification
3H47 2009-06-23 1.9 X-ray Structure of Hexameric HIV-1 CA
1W5Y 2004-10-07 1.9 HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor
2ALF 2005-08-23 1.9 crystal structure of human CypA mutant K131A
2AID 1997-10-15 1.9 STRUCTURE OF A NON-PEPTIDE INHIBITOR COMPLEXED WITH HIV-1 PROTEASE: DEVELOPING A CYCLE OF STRUCTURE-BASED DRUG DESIGN
3NF6 2011-04-27 1.9 Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design
2R3W 2008-09-02 1.92 I84V HIV-1 protease in complex with a amino decorated pyrrolidine-based inhibitor
6C0J 2018-08-01 1.92 Crystal structure of HIV-1 reverse transcriptase in complex with non-nucleoside inhibitor K-5a2
4U1I 2015-04-08 1.92 HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential HIV-1 escape through identical epitopes
4Y1D 2015-05-13 1.93 Cyclic hexapeptide cyc[NdPopPKID] in complex with HIV-1 integrase core domain
1ZJ7 2006-05-09 1.93 Crystal structure of a complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[S-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
6C8Y 2018-12-05 1.94 D30N HIV-1 protease in complex with a phenylboronic acid (P2') analog of darunavir
6CGF 2018-08-01 1.94 Crystal structure of HIV-1 Y188L mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2
6GJP 2018-11-07 1.94 Cyclophilin A complexed with tri-vector ligand 7.
4DQC 2012-03-07 1.94 Crystal Structure of (G16C/L38C) HIV-1 Protease in Complex with DRV
1BIS 1998-08-19 1.95 HIV-1 INTEGRASE CORE DOMAIN
4CF1 2013-12-18 1.95 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4CJV 2014-01-22 1.95 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
6D0E 2019-05-01 1.95 X-ray crystal structure of wild type HIV-1 protease in complex with GRL-084-13
4CJW 2014-01-22 1.95 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
2QI3 2008-04-22 1.95 Crystal structure of protease inhibitor, MIT-2-AD94 in complex with wild type HIV-1 protease
4CHQ 2013-12-11 1.95 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4KO0 2013-08-14 1.95 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH an anilinylpyrimidine derivative (JLJ-135)
4CJ5 2014-01-08 1.95 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4IG3 2013-02-06 1.95 HIV-1 reverse transcriptase with bound fragment near Knuckles site
1G2K 2001-06-01 1.95 HIV-1 PROTEASE WITH CYCLIC SULFAMIDE INHIBITOR, AHA047
4ID5 2013-02-06 1.95 HIV-1 reverse transcriptase with bound fragment at the RNase H primer grip site
4LQW 2013-08-14 1.95 Crystal structure of HIV-1 capsid N-terminal domain in complex with NUP358 cyclophilin
3ZSX 2012-07-11 1.95 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
4CF2 2013-11-20 1.95 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3LZS 2010-08-11 1.95 Crystal Structure of HIV-1 CRF01_AE Protease in Complex with Darunavir
3NF9 2011-04-27 1.95 Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design
5HGP 2016-10-19 1.95 Hexameric HIV-1 CA in complex with hexacarboxybenzene
4CFB 2013-11-27 1.95 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3ZT3 2012-07-11 1.95 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
1BIZ 1998-08-19 1.95 HIV-1 INTEGRASE CORE DOMAIN
3OXW 2011-09-28 1.95 Crystal Structure of HIV-1 I50V, A71V Protease in Complex with the Protease Inhibitor Darunavir
2X2D 2010-03-23 1.95 acetyl-CypA:HIV-1 N-term capsid domain complex
4HLA 2013-07-24 1.95 Crystal structure of wild type HIV-1 protease in complex with darunavir
6C0L 2018-08-01 1.95 Crystal structure of HIV-1 E138K mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2
3MXD 2010-11-10 1.95 Crystal structure of HIV-1 protease inhibitor KC53 in complex with wild-type protease
3LPU 2010-05-12 1.95 HIV integrase
3ZT0 2012-07-11 1.95 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
3NFA 2011-04-27 1.95 Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design
4XRQ 2015-07-15 1.95 Disulfide stabilized HIV-1 CA hexamer 4mut (S41A, Q67H, V165I, L172I) in complex with PF-3450074
4I8W 2013-07-24 1.96 Crystal structure of wild type HIV-1 protease in complex with non-peptidic inhibitor, GRL007
6DUF 2018-08-01 1.96 Crystal structure of HIV-1 reverse transcriptase V106A/F227L mutant in complex with non-nucleoside inhibitor 25a
6C0K 2018-08-01 1.96 Crystal structure of HIV-1 K103N mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2
1D4Y 1999-10-13 1.97 HIV-1 PROTEASE TRIPLE MUTANT/TIPRANAVIR COMPLEX
3EKX 2009-09-01 1.97 Crystal structure of the wild-type HIV-1 protease with the inhibitor, Nelfinavir
3EKT 2009-09-01 1.97 Crystal Structure of the inhibitor Darunavir (DRV) in complex with a multi-drug resistant HIV-1 protease variant (L10F/G48V/I54V/V64I/V82A) (Refer: FLAP+ in citation.)
3LRY 2010-03-09 1.98 Crystal structure of synthetic HIV-1 capsid C-terminal domain (CCA)
6BHS 2018-08-01 1.98 HIV-1 CA hexamer in complex with IP6, hexagonal crystal form
1ZSF 2006-04-25 1.98 Crystal Structure of Complex of a Hydroxyethylamine Inhibitor with HIV-1 Protease at 2.0A Resolution
1NPV 2003-02-04 2.0 Crystal structure of HIV-1 protease complexed with LDC271
6H09 2018-08-15 2.0 HIV capsid hexamer with IP6 ligand
3EL4 2009-09-01 2.0 Crystal structure of inhibitor saquinavir (SQV) complexed with the multidrug HIV-1 protease variant L63P/V82T/I84V
1HPX 1996-03-08 2.0 HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR KNI-272
1ZBG 2006-04-18 2.0 Crystal structure of a complex of mutant hiv-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
4E1N 2012-04-25 2.0 Crystal Structure of HIV-1 Integrase with a non-catayltic site inhibitor
4FE6 2012-07-18 2.0 Crystal Structure of HIV-1 Protease in Complex with an enamino-oxindole inhibitor
1MT9 2003-01-07 2.0 Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
1KJF 2002-03-06 2.0 SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES
1M9C 2003-05-27 2.0 X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type Complex.
1B6P 2000-01-07 2.0 HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 7
1HTG 1994-07-31 2.0 X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE
2NXL 2007-09-18 2.0 Structure of HIV-1 protease D25N complexed with the rt-rh analogue peptide GLY-ALA-GLU-VAL-PHE*TYR-VAL-ASP-GLY-ALA
6B2K 2018-09-26 2.0 E45A/R132T mutant of HIV-1 capsid protein
1VBS 1999-01-13 2.0 STRUCTURE OF CYCLOPHILIN COMPLEXED WITH (D)ALA CONTAINING TETRAPEPTIDE
1A30 1998-04-29 2.0 HIV-1 PROTEASE COMPLEXED WITH A TRIPEPTIDE INHIBITOR
1HVJ 1994-04-30 2.0 INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE
1A94 1999-01-13 2.0 STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES
5NOV 2017-07-12 2.0 Structure of cyclophilin A in complex with hexahydropyrimidine-2-thione
4QNB 2014-12-31 2.0 Disulfide stabilized HIV-1 CA hexamer in complex with PHENYL-L-PHENYLALANINAMIDE inhibitor
1MSN 2003-11-04 2.0 The HIV protease (mutant Q7K L33I L63I V82F I84V) complexed with KNI-764 (an inhibitor)
5T6Z 2017-03-01 2.0 KIR3DL1 in complex with HLA-B*57:01-TW10
1BV9 1998-09-30 2.0 HIV-1 PROTEASE (I84V) COMPLEXED WITH XV638 OF DUPONT PHARMACEUTICALS
1A8K 1999-01-13 2.0 CRYSTALLOGRAPHIC ANALYSIS OF HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEASE WITH AN ANALOG OF THE CONSERVED CA-P2 SUBSTRATE: INTERACTIONS WITH FREQUENTLY OCCURRING GLUTAMIC ACID RESIDUE AT P2' POSITION OF SUBSTRATES
2QI1 2008-04-22 2.0 Crystal structure of protease inhibitor, MIT-1-KK81 in complex with wild type HIV-1 protease
4JMU 2013-10-30 2.0 Crystal structure of HIV matrix residues 1-111 in complex with inhibitor
4QJ8 2014-10-29 2.0 Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with p1-p6 substrate variant (P453L)
3DOX 2008-09-09 2.0 X-ray structure of HIV-1 protease in situ product complex
6DUH 2018-08-01 2.0 Crystal structure of HIV-1 reverse transcriptase Y181I mutant in complex with non-nucleoside inhibitor 25a
4CGD 2013-12-04 2.0 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
2XYE 2011-12-07 2.0 HIV-1 Inhibitors with a Tertiary-Alcohol-containing Transition-State Mimic and various P2 and P1 prime Substituents
3OUC 2011-03-30 2.0 MDR769 HIV-1 protease complexed with p2/NC hepta-peptide
1K6V 2002-02-06 2.0 LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE
2NXD 2007-09-18 2.0 Structure of HIV-1 protease D25N complexed with rt-rh analogue peptide GLY-ALA-ASP-ILE-PHE*TYR-LEU-ASP-GLY-ALA
1RL8 2005-04-19 2.0 Crystal structure of the complex of resistant strain of hiv-1 protease(v82a mutant) with ritonavir
3EL0 2009-09-01 2.0 Crystal structure of the inhibitor Nelfinavir (NFV) in complex with a multi-drug resistant HIV-1 protease variant (L10I/G48V/I54V/V64I/V82A) (Refer: FLAP+ in citation)
1AXA 1998-04-15 2.0 ACTIVE-SITE MOBILITY IN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AS DEMONSTRATED BY CRYSTAL STRUCTURE OF A28S MUTANT
1MSM 2003-11-04 2.0 The HIV protease (mutant Q7K L33I L63I) complexed with KNI-764 (an inhibitor)
1DMP 1997-11-12 2.0 STRUCTURE OF HIV-1 PROTEASE COMPLEX
5VJ3 2018-04-18 2.0 HIV Protease (PR) in open form with Mg2+ in active site and HIVE-9 in eye site
5VEA 2018-04-25 2.0 HIV Protease (PR) with TL-3 in active site and 4-methylbenzene-1,2-diamine in exosite
1AJX 1997-09-17 2.0 HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC UREA INHIBITOR AHA001
6C0N 2018-08-01 2.0 Crystal structure of HIV-1 reverse transcriptase in complex with non-nucleoside inhibitor 25a
1MRX 2003-11-04 2.0 Structure of HIV protease (Mutant Q7K L33I L63I V82F I84V ) complexed with KNI-577
1F7A 2001-06-27 2.0 HOW DOES A SYMMETRIC DIMER RECOGNIZE AN ASYMMETRIC SUBSTRATE? A SUBSTRATE COMPLEX OF HIV-1 PROTEASE.
1TSQ 2005-03-29 2.0 CRYSTAL STRUCTURE OF AP2V SUBSTRATE VARIANT OF NC-P1 DECAMER PEPTIDE IN COMPLEX WITH V82A/D25N HIV-1 PROTEASE MUTANT
2O4N 2006-12-12 2.0 Crystal Structure of HIV-1 Protease (TRM Mutant) in Complex with Tipranavir
2Q3K 2007-08-21 2.0 Crystal Structure of Lysine Sulfonamide Inhibitor Reveals the Displacement of the Conserved Flap Water Molecule in HIV-1 Protease
2AQU 2006-08-29 2.0 Structure of HIV-1 protease bound to atazanavir
1HIV 1993-10-31 2.0 CRYSTAL STRUCTURE OF A COMPLEX OF HIV-1 PROTEASE WITH A DIHYDROETHYLENE-CONTAINING INHIBITOR: COMPARISONS WITH MOLECULAR MODELING
1CWM 1998-07-15 2.0 HUMAN CYCLOPHILIN A COMPLEXED WITH 4 MEILE CYCLOSPORIN
2FGU 2006-11-07 2.0 X-ray crystal structure of HIV-1 Protease T80S variant in complex with the inhibitor saquinavir used to explore the role of invariant Thr80 in HIV-1 protease structure, function, and viral infectivity.
1KJG 2002-03-06 2.0 SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES
1BV7 1998-09-30 2.0 COUNTERACTING HIV-1 PROTEASE DRUG RESISTANCE: STRUCTURAL ANALYSIS OF MUTANT PROTEASES COMPLEXED WITH XV638 AND SD146, CYCLIC UREA AMIDES WITH BROAD SPECIFICITIES
1ODY 1999-02-16 2.0 HIV-1 PROTEASE COMPLEXED WITH AN INHIBITOR LP-130
1NPA 2004-01-27 2.0 crystal structure of HIV-1 protease-hup
4CJP 2014-01-08 2.0 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1NPW 2003-02-04 2.0 Crystal structure of HIV protease complexed with LGZ479
5HGO 2016-08-10 2.0 Hexameric HIV-1 CA R18G mutant
1EC2 2002-06-26 2.0 HIV-1 protease in complex with the inhibitor BEA428
3TLH 1998-12-09 2.0 STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITHAN EFFICIENT INHIBITOR OF FIV PR
1BL3 1998-09-30 2.0 CATALYTIC DOMAIN OF HIV-1 INTEGRASE
4CHN 2013-12-11 2.0 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1KJ7 2002-03-06 2.0 SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES
3LPT 2010-05-12 2.0 HIV integrase
3ZSZ 2012-07-11 2.0 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
1KJH 2002-03-06 2.0 SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES
5T9W 2017-01-25 2.0 Discovery of a Potent Cyclophilin Inhibitor (Compound 5) based on Structural Simplification of Sanglifehrin A
5HVP 1991-10-15 2.0 CRYSTALLOGRAPHIC ANALYSIS OF A COMPLEX BETWEEN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AND ACETYL-PEPSTATIN AT 2.0-ANGSTROMS RESOLUTION
6CPN 2018-06-06 2.0 Crystal structure of DR11 presenting the RQ13 peptide
1AJV 1997-08-20 2.0 HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006
1HSG 1996-04-03 2.0 CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES
2AZ8 2006-02-28 2.0 HIV-1 Protease NL4-3 in complex with inhibitor, TL-3
1ODX 1997-04-01 2.0 HIV-1 Proteinase mutant A71T, V82A
1MRW 2003-11-04 2.0 Structure of HIV protease (Mutant Q7K L33I L63I) complexed with KNI-577
5V5L 2017-06-14 2.0 Crystal structure of HLA-B*5801 complex with HIV-1 gag derived peptide TW10
7UPJ 1997-04-21 2.0 HIV-1 PROTEASE/U101935 COMPLEX
6EX9 2018-06-06 2.01 Crystal Structure of HIV-1 Integrase Catalytic Core Domain with Inhibitor Peptide
3DPH 2008-09-02 2.01 HIV-1 capsid C-terminal domain mutant (L211S)
2AZC 2006-02-28 2.01 HIV-1 Protease NL4-3 6X mutant
1EBZ 2002-06-26 2.01 HIV-1 protease in complex with the inhibitor BEA388
4XRO 2015-07-15 2.01 Disulfide stabilized HIV-1 CA hexamer 4mut (S41A, Q67H, V165I, L172I)
1B92 1999-07-19 2.02 MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY
1ZPA 2005-05-31 2.02 HIV Protease with Scripps AB-3 Inhibitor
2B4J 2005-10-25 2.02 Structural basis for the recognition between HIV-1 integrase and LEDGF/p75
2AZB 2006-02-28 2.03 HIV-1 Protease NL4-3 3X mutant in complex with inhibitor, TL-3
4U0E 2014-11-12 2.04 Hexameric HIV-1 CA in complex with PF3450074
3K2P 2010-02-09 2.04 HIV-1 Reverse Transcriptase Isolated RnaseH Domain with the Inhibitor beta-thujaplicinol Bound at the Active Site
5HGM 2016-08-10 2.04 Hexameric HIV-1 CA in complex with dATP
3U7S 2012-01-18 2.05 HIV PR drug resistant patient's variant in complex with darunavir
4U0A 2014-11-12 2.05 Hexameric HIV-1 CA in complex with CPSF6 peptide, P6 crystal form
4CFA 2013-11-27 2.05 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
4IFV 2013-02-06 2.05 Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-Ray Crystallographic Fragment Screening
6C0R 2018-08-01 2.05 Crystal structure of HIV-1 K103N/Y181C mutant reverse transcriptase in complex with non-nucleoside inhibitor 25a
4O0J 2014-07-02 2.05 HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[4-(4-chlorophenyl)-6-(3,4-dimethylphenyl)-2,5-dimethylpyridin-3-yl]ethanoic acid
1CPI 1996-03-08 2.05 REGIOSELECTIVE STRUCTURAL AND FUNCTIONAL MIMICRY OF PEPTIDES. DESIGN OF HYDROLYTICALLY STABLE CYCLIC PEPTIDOMIMETIC INHIBITORS OF HIV-1 PROTEASE
5TEO 2017-09-27 2.05 Dimer of HIV-1 Gag CTD-SP1 fragment
6C0P 2018-08-01 2.05 Crystal structure of HIV-1 E138K mutant reverse transcriptase in complex with non-nucleoside inhibitor 25a
1EBK 2000-07-26 2.06 Structural and kinetic analysis of drug resistant mutants of HIV-1 protease
1ZSR 2006-04-25 2.06 Crystal structure of wild type HIV-1 protease (BRU isolate) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[S-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
4CGI 2013-12-04 2.07 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
3PSU 2011-12-07 2.07 HIV-1 protease in complex with an isobutyl decorated oligoamine (symmetric binding mode)
4JLH 2013-05-01 2.09 HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor
3QIP 2011-04-20 2.09 Structure of HIV-1 reverse transcriptase in complex with an RNase H inhibitor and nevirapine
5W4O 2018-06-20 2.09 Structure of the R18A mutant of the HIV-1 capsid protein
3AVN 2012-01-18 2.1 Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site
5CYH 1996-07-11 2.1 CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE GLY-PRO
1ODW 1997-04-01 2.1 Native HIV-1 Proteinase
3T3C 2012-06-20 2.1 Structure of HIV PR resistant patient derived mutant (comprising 22 mutations) in complex with DRV
4PHV 1993-10-31 2.1 X-RAY CRYSTAL STRUCTURE OF THE HIV PROTEASE COMPLEX WITH L-700,417, AN INHIBITOR WITH PSEUDO C2 SYMMETRY
3EM6 2009-09-01 2.1 Crystal structure of I50L/A71V mutant of hiv-1 protease in complex with inhibitor darunavir
4IDK 2013-02-06 2.1 HIV-1 reverse transcriptase with bound fragment at the 428 site
1T7K 2004-10-05 2.1 Crystal Structure of HIV Protease complexed with Arylsulfonamide azacyclic urea
4CE9 2013-11-20 2.1 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1TSU 2005-03-29 2.1 CRYSTAL STRUCTURE OF DECAMER NCP1 SUBSTRATE PEPTIDE IN COMPLEX WITH WILD-TYPE D25N HIV-1 PROTEASE VARIANT
2RMA 1995-02-07 2.1 Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A
4CF9 2013-11-27 2.1 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1NMK 2003-04-01 2.1 The Sanglifehrin-Cyclophilin Interaction: Degradation Work, Synthetic Macrocyclic Analogues, X-ray Crystal Structure and Binding Data
5T70 2017-03-01 2.1 KIR3DL1 in complex with HLA-B*57:01 presenting TSNLQEQIGW
2X4U 2010-03-02 2.1 Crystal structure of MHC CLass I HLA-A2.1 bound to HIV-1 Peptide RT468-476
1CWA 1996-01-29 2.1 X-RAY STRUCTURE OF A MONOMERIC CYCLOPHILIN A-CYCLOSPORIN A CRYSTAL COMPLEX AT 2.1 ANGSTROMS RESOLUTION
4FAF 2012-08-29 2.1 Substrate CA/p2 in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant
1LV1 2002-06-19 2.1 Crystal Structure Analysis of the non-active site mutant of tethered HIV-1 protease to 2.1A resolution
2RMB 1995-02-07 2.1 Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A
4IFY 2013-02-06 2.1 HIV-1 reverse transcriptase with bound fragment at the Knuckles site
3BGR 2008-02-12 2.1 Crystal structure of K103N/Y181C mutant HIV-1 reverse transcriptase (RT) in complex with TMC278 (Rilpivirine), a non-nucleoside RT inhibitor
2QI0 2008-04-22 2.1 Crystal structure of protease inhibitor, MIT-1-KK80 in complex with wild type HIV-1 protease
1EC1 2002-06-26 2.1 HIV-1 protease in complex with the inhibitor BEA409
5CYM 2015-12-30 2.1 HIV-1 reverse transcriptase complexed with 4-iodopyrazole
3EM4 2009-09-01 2.1 Crystal structure of atazanavir (ATV) in complex with I50L/A71V drug-resistant HIV-1 protease
4CYH 1996-07-11 2.1 CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE HIS-PRO
1QS4 1999-11-17 2.1 Core domain of HIV-1 integrase complexed with Mg++ and 1-(5-chloroindol-3-yl)-3-hydroxy-3-(2H-tetrazol-5-yl)-propenone
1QBT 1997-10-15 2.1 HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
2YKN 2011-08-17 2.12 Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with a Difluoromethylbenzoxazole (DFMB) Pyrimidine Thioether derivative, a non-nucleoside RT inhibitor (NNRTI)
2YNG 2013-01-09 2.12 HIV-1 Reverse Transcriptase in complex with inhibitor GSK560
5IND 2016-10-05 2.13 Crystal structure of HLA-B5801, a protective HLA allele for HIV-1 infection
4QJ2 2014-10-29 2.13 Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with WT p1-p6 substrate
3RDD 2012-03-21 2.14 Human Cyclophilin A Complexed with an Inhibitor
4CGJ 2013-12-04 2.15 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1MT8 2003-01-07 2.15 Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
5CYQ 2015-12-30 2.15 HIV-1 reverse transcriptase complexed with 4-bromopyrazole
4CFD 2013-11-27 2.15 Interrogating HIV integrase for compounds that bind- a SAMPL challenge
1IZI 2002-12-23 2.15 Inhibitor of HIV protease with unusual binding mode potently inhibiting multi-resistant protease mutants
1ZTZ 2005-11-01 2.15 Crystal structure of HIV protease- metallacarborane complex
6JCF 2019-07-17 2.15 Cryogenic structure of HIV-1 Integrase catalytic core domain by synchrotron
3LZV 2010-08-11 2.15 Structure of Nelfinavir-resistant HIV-1 protease (D30N/N88D) in complex with Darunavir.
4DG1 2012-06-20 2.15 Crystal structure of HIV-1 reverse transcriptase (RT) with polymorphism mutation K172A and K173A
3EKP 2009-09-01 2.15 Crystal Structure of the inhibitor Amprenavir (APV) in complex with a multi-drug resistant HIV-1 protease variant (L10I/G48V/I54V/V64I/V82A)Refer: FLAP+ in citation
4GVM 2013-05-01 2.16 HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor
4LH5 2013-12-25 2.19 Dual inhibition of HIV-1 replication by Integrase-LEDGF allosteric inhibitors is predominant at post-integration stage during virus production rather than at integration
5W4P 2018-06-20 2.19 Structure of the E28A mutant of the HIV-1 capsid protein
4DGE 2012-02-08 2.2 TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant, HIV-1 CA(O-loop) complex
1YTH 1997-03-12 2.2 SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT
3ZT4 2012-07-18 2.2 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
1U8G 2004-11-02 2.2 Crystal structure of a HIV-1 Protease in complex with peptidomimetic inhibitor KI2-PHE-GLU-GLU-NH2
1VRT 1996-04-03 2.2 HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
3ZSY 2012-07-11 2.2 Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
3EKQ 2009-09-01 2.2 Crystal structure of inhibitor saquinavir (SQV) in complex with multi-drug resistant HIV-1 protease (L63P/V82T/I84V) (referred to as ACT in paper)
1E27 2000-09-12 2.2 Nonstandard peptide binding of HLA-B*5101 complexed with HIV immunodominant epitope KM1(LPPVVAKEI)
1LZQ 2003-04-29 2.2 Crystal structure of the complex of mutant HIV-1 protease (A71V, V82T, I84V) with an ethylenamine peptidomimetic inhibitor BOC-PHE-PSI[CH2CH2NH]-PHE-GLU-PHE-NH2
5OIA 2018-03-07 2.2 Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
1RTH 1996-04-03 2.2 HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
3UHL 2012-03-28 2.2 Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with p2-NC substrate analog
1HAR 1995-04-20 2.2 2.2 ANGSTROMS RESOLUTION STRUCTURE OF THE AMINO-TERMINAL HALF OF HIV-1 REVERSE TRANSCRIPTASE (FINGERS AND PALM SUBDOMAINS)
2QAK 2008-07-01 2.2 HIV-1 PR mutant in complex with nelfinavir
1Z8C 2006-03-21 2.2 Crystal structure of the complex of mutant HIV-1 protease (l63P, A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
4F74 2013-05-15 2.2 Crystal Structure of active HIV-1 Protease in Complex with the N terminal product of the substrate MA-CA.
1AID 1997-10-15 2.2 STRUCTURE OF A NON-PEPTIDE INHIBITOR COMPLEXED WITH HIV-1 PROTEASE: DEVELOPING A CYCLE OF STRUCTURE-BASED DRUG DESIGN
1K6C 2002-02-06 2.2 LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE
1N49 2003-01-07 2.2 Viability of a Drug-Resistant HIV-1 Protease Variant: Structural Insights for Better Anti-Viral Therapy
1HEF 1994-05-31 2.2 The crystal structures at 2.2 angstroms resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations
1HTF 1994-07-31 2.2 X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE
3EM3 2009-09-01 2.2 Crystal structure of amprenavir (APV) in complex with a drug resistant HIV-1 protease variant (I50L/A71V).
1BHL 1998-10-14 2.2 CACODYLATED CATALYTIC DOMAIN OF HIV-1 INTEGRASE
5OI2 2018-03-07 2.2 Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
1CWB 1996-01-29 2.2 THE X-RAY STRUCTURE OF (MEBM2T)1-CYCLOSPORIN COMPLEXED WITH CYCLOPHILIN A PROVIDES AN EXPLANATION FOR ITS ANOMALOUSLY HIGH IMMUNOSUPPRESSIVE ACTIVITY
2Q63 2008-02-26 2.2 HIV-1 PR mutant in complex with nelfinavir
3KDC 2010-03-16 2.2 Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10074
6ELI 2018-04-11 2.2 Structure of HIV-1 reverse transcriptase (RT) in complex with rilpivirine and an RNase H inhibitor XZ462
3ODI 2011-02-16 2.2 Crystal structure of cyclophilin A in complex with Voclosporin E-ISA247
1T7J 2005-05-10 2.2 crystal structure of inhibitor amprenavir in complex with a multi-drug resistant variant of HIV-1 protease (L63P/V82T/I84V)
2B7Z 2006-11-14 2.2 Structure of HIV-1 protease mutant bound to indinavir
1HIH 1995-07-10 2.2 COMPARATIVE ANALYSIS OF THE X-RAY STRUCTURES OF HIV-1 AND HIV-2 PROTEASES IN COMPLEX WITH CGP 53820, A NOVEL PSEUDOSYMMETRIC INHIBITOR
1K2C 2002-07-10 2.2 Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
1HEG 1994-05-31 2.2 The crystal structures at 2.2 angstroms resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations
1K6P 2002-02-06 2.2 LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE
3DLG 2008-08-12 2.2 Crystal structure of hiv-1 reverse transcriptase in complex with GW564511.
6B2J 2018-09-26 2.21 E45A mutant of HIV-1 capsid protein (other crystal form)
1UPJ 1996-10-14 2.22 HIV-1 PROTEASE COMPLEX WITH U095438 [3-[1-(4-BROMOPHENYL) ISOBUTYL]-4-HYDROXYCOUMARIN
4U0F 2014-11-12 2.22 Hexameric HIV-1 CA in Complex with BI-2
3T11 2012-08-22 2.22 Dimeric inhibitor of HIV-1 protease.
6DUG 2018-08-01 2.22 Crystal structure of HIV-1 reverse transcriptase K101P mutant in complex with non-nucleoside inhibitor 25a
3TTP 2012-09-26 2.23 Structure of multiresistant HIV-1 protease in complex with darunavir
5VQZ 2017-08-23 2.23 Crystal Structure of HIV-1 Reverse Transcriptase (K103N, Y181C) Variant in Complex with 2-chloro-N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacetamide (JLJ686), a Non-nucleoside Inhibitor
3LP1 2010-06-09 2.23 HIV-1 reverse transcriptase with inhibitor
4O55 2014-07-02 2.24 HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[6-(5-chloro-1H-benzimidazol-2-yl)-2,5-dimethyl-4-phenylpyridin-3-yl]ethanoic acid
2NXM 2007-09-18 2.25 Structure of HIV-1 protease D25N complexed with the rt-rh analogue peptide GLY-ALA-GLN-THR-PHE*TYR-VAL-ASP-GLY-ALA
3PJ6 2011-04-06 2.25 Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants
1SJH 2004-08-17 2.25 HLA-DR1 complexed with a 13 residue HIV capsid peptide
1HVS 1995-02-14 2.25 STRUCTURAL BASIS OF DRUG RESISTANCE FOR THE V82A MUTANT OF HIV-1 PROTEASE: BACKBONE FLEXIBILITY AND SUBSITE REPACKING
1K6T 2002-02-06 2.25 LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE
3OQA 2011-04-06 2.25 Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants
5W4Q 2018-06-20 2.29 Structure of the R18A/E28A mutant of the HIV-1 capsid protein
1EBY 2002-06-26 2.29 HIV-1 protease in complex with the inhibitor BEA369
1ITG 1995-05-08 2.3 CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE: SIMILARITY TO OTHER POLYNUCLEOTIDYL TRANSFERASES
5D3G 2015-09-30 2.3 Structure of HIV-1 Reverse Transcriptase Bound to a Novel 38-mer Hairpin Template-Primer DNA Aptamer
2R5Q 2007-11-20 2.3 Crystal Structure Analysis of HIV-1 Subtype C Protease Complexed with Nelfinavir
1GNO 1996-11-08 2.3 HIV-1 PROTEASE (WILD TYPE) COMPLEXED WITH U89360E (INHIBITOR)
1HBV 1995-07-10 2.3 A CHECK ON RATIONAL DRUG DESIGN. CRYSTAL STRUCTURE OF A COMPLEX OF HIV-1 PROTEASE WITH A NOVEL GAMMA-TURN MIMETIC
4Y1C 2015-02-25 2.3 Cyclic hexapeptide cyc[NdPopPKID] in complex with HIV-1 integrase core domain
4KV8 2013-07-31 2.3 Crystal structure of HIV RT in complex with BILR0355BS
1GNN 1996-11-08 2.3 HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASN (V82N) COMPLEXED WITH U89360E (INHIBITOR)
1SBG 1994-10-15 2.3 AN ORALLY-BIOAVAILABLE HIV-1 PROTEASE INHIBITOR CONTAINING AN IMIDAZOLE-DERIVED PEPTIDE BOND REPLACEMENT. CRYSTALLOGRAPHIC AND PHARMACOKINETIC ANALYSIS
1A9M 1998-06-17 2.3 G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E
1HOS 1993-10-31 2.3 INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE BY A C2-SYMMETRIC PHOSPHINATE SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS
5T9U 2017-01-25 2.3 Discovery of a Potent Cyclophilin Inhibitor (Compound 3) based on Structural Simplification of Sanglifehrin A
6AXR 2018-09-12 2.3 Structure of the P122A mutant of the HIV-1 capsid protein
2QNQ 2008-04-15 2.3 HIV-1 Protease in complex with a chloro decorated pyrrolidine-based inhibitor
1GNM 1996-11-08 2.3 HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASP (V82D) COMPLEXED WITH U89360E (INHIBITOR)
1ZLF 2006-04-25 2.3 Crystal structure of a complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor
3LAK 2010-02-23 2.3 Crystal structure of HIV-1 reverse transcriptase in complex with N1-heterocycle pyrimidinedione non-nucleoside inhibitor
4I2P 2013-01-16 2.3 Crystal structure of HIV-1 reverse transcriptase in complex with rilpivirine (TMC278) based analogue
3DYA 2008-11-25 2.3 HIV-1 RT with non-nucleoside inhibitor annulated Pyrazole 1
1HPS 1994-08-31 2.3 RATIONAL DESIGN, SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS OF A HYDROXYETHYLENE-BASED HIV-1 PROTEASE INHIBITOR CONTAINING A HETEROCYCLIC P1'-P2' AMIDE BOND ISOSTERE
2R5P 2007-11-20 2.3 Crystal Structure Analysis of HIV-1 Subtype C Protease Complexed with Indinavir
5OI3 2018-03-07 2.3 Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
4HVP 1990-04-15 2.3 Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 Angstroms resolution
1HXB 1997-03-12 2.3 HIV-1 proteinase complexed with RO 31-8959
1HIW 1996-10-14 2.3 TRIMERIC HIV-1 MATRIX PROTEIN
2RKI 2008-04-22 2.3 Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with a triazole derived NNRTI
3MEC 2010-05-12 2.3 HIV-1 Reverse Transcriptase in Complex with TMC125
1VBT 1999-01-13 2.3 Structure of cyclophilin complexed with sulfur-substituted tetrapeptide AAPF
2OPS 2007-05-22 2.3 Crystal Structure of Y188C Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
1HYZ 2001-04-04 2.3 HIV INTEGRASE CORE DOMAIN COMPLEXED WITH A DERIVATIVE OF TETRAPHENYL ARSONIUM.
1YTG 1997-03-12 2.3 SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT
1TCX 1996-12-07 2.3 HIV TRIPLE MUTANT PROTEASE COMPLEXED WITH INHIBITOR SB203386
2Z54 2008-07-01 2.31 The Influence of I47A Mutation on Reduced Susceptibility to the Protease Inhibitor Lopinavir
4K4P 2013-09-18 2.31 TL-3 inhibited Trp6Ala HIV Protease
3ODL 2011-02-16 2.31 Crystal structure of cyclophilin A in complex with Voclosporin Z-ISA247
3K0Q 2009-12-08 2.32 Cryogenic structure of CypA mutant Ser99Thr (2)
1AWV 1998-03-18 2.34 CYPA COMPLEXED WITH HVGPIA
5KGW 2016-10-19 2.34 HIV1 catalytic core domain in complex with inhibitor: (2~{S})-2-[3-(3,4-dihydro-2~{H}-chromen-6-yl)-1-methyl-indol-2-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid
1AWU 1998-03-18 2.34 CYPA COMPLEXED WITH HVGPIA (PSEUDO-SYMMETRIC MONOMER)
4EJ8 2013-05-01 2.35 Apo HIV Protease (PR) dimer in closed form with fragment 1F1 in the outside/top of flap
5VQY 2017-08-23 2.35 Crystal Structure of HIV-1 Reverse Transcriptase (K103N, Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacrylamide (JLJ684), a Non-nucleoside Inhibitor
5OI8 2018-03-07 2.35 Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
1RTJ 1996-04-03 2.35 MECHANISM OF INHIBITION OF HIV-1 REVERSE TRANSCRIPTASE BY NON-NUCLEOSIDE INHIBITORS
4CPQ 2014-12-17 2.35 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
2YNF 2013-01-09 2.36 HIV-1 Reverse Transcriptase Y188L mutant in complex with inhibitor GSK560
1AK4 1997-10-15 2.36 HUMAN CYCLOPHILIN A BOUND TO THE AMINO-TERMINAL DOMAIN OF HIV-1 CAPSID
4O5B 2014-07-02 2.37 HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[6-(5-chloro-1H-benzimidazol-2-yl)-2,5-dimethyl-4-phenylpyridin-3-yl]ethanoic acid
5XN2 2018-02-07 2.38 HIV-1 reverse transcriptase Q151M:DNA:dGTP ternary complex
6ECL 2019-08-21 2.38 Crystal Structure of a 1,2,4-Triazole Allosteric RNase H Inhibitor in Complex with HIV Reverse Transcriptase
6EWA 2018-11-07 2.39 Crystal structure of HLA-A2 in complex with LILRB1
6AXT 2018-09-12 2.4 Structure of the T58S/T107I/P122A mutant of the HIV-1 capsid protein
5OI5 2018-03-07 2.4 Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
6CQL 2018-06-06 2.4 Crystal structure of F24 TCR -DR11-RQ13 peptide complex
6AXW 2018-09-12 2.4 Structure of the I124A mutant of the HIV-1 capsid protein
1RMH 1996-10-14 2.4 RECOMBINANT CYCLOPHILIN A FROM HUMAN T CELL
1VIK 1998-12-09 2.4 HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR HOE/BAY 793 ORTHORHOMBIC FORM
3T1A 2011-10-26 2.4 Crystal Structure of HIV-1 Reverse Transcriptase (K103N mutant) in Complex with Inhibitor M05
7HVP 1993-07-15 2.4 X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN A SYNTHETIC PROTEASE OF HUMAN IMMUNODEFICIENCY VIRUS 1 AND A SUBSTRATE-BASED HYDROXYETHYLAMINE INHIBITOR
1K6Y 2001-12-21 2.4 Crystal Structure of a Two-Domain Fragment of HIV-1 Integrase
1HRH 1992-01-15 2.4 CRYSTAL STRUCTURE OF THE RIBONUCLEASE H DOMAIN OF HIV-1 REVERSE TRANSCRIPTASE
1VRU 1996-04-03 2.4 HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
5VQX 2017-08-23 2.4 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with 2-chloro-N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacetamide (JLJ686), a Non-nucleoside Inhibitor
3MEE 2010-05-12 2.4 HIV-1 Reverse Transcriptase in Complex with TMC278
5K14 2016-06-29 2.4 HIV-1 Reverse Transcriptase in complex with a 2,6-difluorophenyl DAPY analog
4G8G 2013-03-20 2.4 Crystal Structure of C12C TCR-HA B2705-KK10
6CPO 2018-06-06 2.4 Crystal structure of DR15 presenting the RQ13 peptide
6AXS 2018-09-12 2.4 Structure of the V11I/T58A/P122A mutant of the HIV-1 capsid protein
6AYA 2018-09-12 2.4 Structure of the native full-length HIV-1 capsid protein in complex with Nup153 peptide
1VIJ 1999-01-13 2.4 HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR HOE/BAY 793 HEXAGONAL FORM
6O9E 2019-10-23 2.4 Structure of HIV-1 Reverse Transcriptase in complex with DNA and INDOPY-1
3DS5 2008-09-02 2.4 HIV-1 capsid C-terminal domain mutant (N183A)
1Q94 2004-06-01 2.4 Structures of HLA-A*1101 in complex with immunodominant nonamer and decamer HIV-1 epitopes clearly reveal the presence of a middle anchor residue
2RF2 2008-01-01 2.4 HIV reverse transcriptase in complex with inhibitor 7e (NNRTI)
1S1T 2004-06-29 2.4 Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with UC-781
2X2C 2010-03-23 2.41 acetyl-CypA:cyclosporine complex
6B2G 2018-09-26 2.41 P38A mutant of HIV-1 capsid protein
3K0R 2009-12-08 2.42 Cryogenic structure of CypA mutant Arg55Lys
5J2M 2016-08-03 2.43 HIV-1 reverse transcriptase in complex with DNA and EFdA-triphosphate, a translocation-defective RT inhibitor
2BE2 2005-12-06 2.43 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with R221239
6IK9 2019-01-30 2.43 HIV-1 reverse transcriptase with Q151M/G112S/D113A/Y115F/F116Y/F160L/I159L:DNA:dGTP ternary complex
4XFX 2015-06-10 2.43 Structure of the native full-length HIV-1 capsid protein
6BSG 2018-01-03 2.44 Structure of HIV-1 RT complexed with RNA/DNA hybrid in an RNA hydrolysis-off mode
4EJL 2013-05-01 2.44 Apo HIV Protease (PR) dimer in closed form with fragment 1F1-N in the outside/top of flap
1M0B 2004-01-13 2.45 HIV-1 protease in complex with an ethyleneamine inhibitor
4DMN 2012-03-21 2.45 HIV-1 Integrase Catalytical Core Domain
4QLH 2014-08-06 2.45 Crystal structure of drug resistant V82S/V1082S HIV-1 Protease
5XN1 2018-02-07 2.45 HIV-1 reverse transcriptase Q151M:DNA:entecavir-triphosphate ternary complex
4COE 2014-12-10 2.45 Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol
1SJE 2004-08-17 2.45 HLA-DR1 complexed with a 16 residue HIV capsid peptide bound in a hairpin conformation
6CPL 2018-06-06 2.45 Crystal structure of DR11 presenting the gag293 epitope
4WE1 2014-12-03 2.49 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ600)
2YNI 2013-01-09 2.49 HIV-1 Reverse Transcriptase in complex with inhibitor GSK952
6AMO 2018-08-15 2.5 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 7.0
3N3I 2010-06-09 2.5 Crystal Structure of G48V/C95F tethered HIV-1 Protease/Saquinavir complex
1D4S 1999-10-12 2.5 HIV-1 PROTEASE V82F/I84V DOUBLE MUTANT/TIPRANAVIR COMPLEX
1HPO 1997-04-21 2.5 HIV-1 PROTEASE TRIPLE MUTANT/U103265 COMPLEX
1EP4 2000-09-27 2.5 Crystal structure of HIV-1 reverse transcriptase in complex with S-1153
4IG0 2013-02-06 2.5 HIV-1 reverse transcriptase with bound fragment at the 507 site
1BDQ 1998-08-12 2.5 HIV-1 (2:31-37, 47, 82) PROTEASE COMPLEXED WITH INHIBITOR SB203386
6B2I 2018-09-26 2.5 E45A mutant of the HIV-1 capsid protein
6AY9 2018-09-12 2.5 Structure of the native full-length HIV-1 capsid protein in complex with CPSF6 peptide
1SH9 2004-10-05 2.5 Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease
4I7F 2013-02-20 2.5 HIV-1 Reverse Transcriptase in complex with a phosphonate analog of nevirapine
3GGA 2009-05-26 2.5 HIV Protease inhibitors with pseudo-symmetric cores
1BI4 1998-11-04 2.5 CATALYTIC DOMAIN OF HIV-1 INTEGRASE
5TSV 2017-11-08 2.5 HIV-1 CA hexamer with NUP153 peptide - R3 crystal form
3MED 2010-05-12 2.5 HIV-1 K103N Reverse Transcriptase in Complex with TMC125
5VQS 2017-08-23 2.5 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)acrylamide (JLJ685), a Non-nucleoside Inhibitor
1FK9 2000-11-03 2.5 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
1BIU 1998-08-19 2.5 HIV-1 INTEGRASE CORE DOMAIN COMPLEXED WITH MG++
2BPZ 1999-02-23 2.5 HIV-1 protease-inhibitor complex
1HHJ 1993-10-31 2.5 THE ANTIGENIC IDENTITY OF PEPTIDE(SLASH)MHC COMPLEXES: A COMPARISON OF THE CONFORMATION OF FIVE PEPTIDES PRESENTED BY HLA-A2
5VQW 2017-08-23 2.5 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)acrylamide (JLJ685), a Non-nucleoside Inhibitor
5IM7 2016-10-05 2.5 Crystal structure of HLA-B5801, a protective HLA allele for HIV-1 infection
2AZ9 2006-02-28 2.5 HIV-1 Protease NL4-3 1X mutant
8HVP 1993-10-31 2.5 STRUCTURE AT 2.5-ANGSTROMS RESOLUTION OF CHEMICALLY SYNTHESIZED HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE COMPLEXED WITH A HYDROXYETHYLENE*-BASED INHIBITOR
1MTB 2003-01-07 2.5 Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
2HNY 2006-09-05 2.5 Crystal Structure of E138K Mutant HIV-1 Reverse Transcriptase in Complex with Nevirapine
3AID 1997-09-17 2.5 A NEW CLASS OF HIV-1 PROTEASE INHIBITOR: THE CRYSTALLOGRAPHIC STRUCTURE, INHIBITION AND CHEMICAL SYNTHESIS OF AN AMINIMIDE PEPTIDE ISOSTERE
3P05 2011-01-12 2.5 X-ray structure of pentameric HIV-1 CA
6CQN 2018-06-06 2.5 Crystal structure of F5 TCR -DR11-RQ13 peptide complex
2HND 2006-09-05 2.5 Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with Nevirapine
1JKH 2001-10-03 2.5 CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
6JCG 2019-07-17 2.5 Room temperature structure of HIV-1 Integrase catalytic core domain by serial femtosecond crystallography.
2IAJ 2006-12-19 2.5 Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with ATP
1JLA 2001-10-03 2.5 CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-651
1A8G 1998-07-15 2.5 HIV-1 PROTEASE IN COMPLEX WITH SDZ283-910
5TXL 2017-04-05 2.5 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP
2Q64 2008-02-26 2.5 HIV-1 PR mutant in complex with nelfinavir
3ISN 2010-03-16 2.5 Crystal structure of HIV-1 RT bound to A 6-vinylpyrimidine inhibitor
1C1B 2000-07-21 2.5 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GCA-186
6AVM 2018-08-15 2.5 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 9.5 WITH CROSS-LINKING TO SECOND BASE TEMPLATE OVERHANG
1AAQ 1994-06-22 2.5 HYDROXYETHYLENE ISOSTERE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE: STRUCTURE-ACTIVITY ANALYSIS USING ENZYME KINETICS, X-RAY CRYSTALLOGRAPHY, AND INFECTED T-CELL ASSAYS
3DLE 2008-08-12 2.5 Crystal structure of hiv-1 reverse transcriptase in complex with GF128590.
1C1C 2000-07-21 2.5 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-6123
4PQU 2014-06-18 2.51 Crystal structure of HIV-1 Reverse Transcriptase in complex with RNA/DNA and dATP
3LAL 2010-02-23 2.51 Crystal structure of HIV-1 reverse transcriptase in complex with N1-ethyl pyrimidinedione non-nucleoside inhibitor
3TAM 2011-10-26 2.51 Crystal structure of HIV-1 reverse transcriptase (K103N mutant) in complex with inhibitor M06
1C0U 2000-07-19 2.52 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+50.0934
6OR7 2019-07-24 2.53 Structure of HIV-1 Reverse Transcriptase (RT) in complex with DNA AND (-)FTC-TP
5J2P 2016-08-03 2.53 HIV-1 reverse transcriptase in complex with DNA that has incorporated EFdA-MP at the P-(post-translocation) site and a second EFdA-MP at the N-(pre-translocation) site
3IS9 2010-04-07 2.55 Crystal structure of the HIV-1 reverse transcriptase (RT) in complex with the alkenyldiarylmethane (ADAM) Non-nucleoside RT Inhibitor dimethyl 3,3'-(6-methoxy-6-oxohex-1-ene-1,1-diyl)bis(5-cyano-6-methoxybenzoate).
1ZKF 2006-04-11 2.55 Cyrstal Structure of Human Cyclophilin-A in Complex with suc-AGPF-pNA
5TXN 2017-04-05 2.55 STRUCTURE OF Q151M MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP
2R05 2007-12-18 2.55 Crystal Structure of ALIX/AIP1 in complex with the HIV-1 YPLASL Late Domain
1AWS 1998-03-18 2.55 SECYPA COMPLEXED WITH HAGPIA (PSEUDO-SYMMETRIC MONOMER)
1RT2 1997-04-21 2.55 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH TNK-651
1AWT 1998-03-18 2.55 SECYPA COMPLEXED WITH HAGPIA
2OPP 2007-05-22 2.55 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with GW420867X.
5VQQ 2017-08-23 2.55 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-2-fluoro-N-methylacetamide (JLJ683), a Non-nucleoside Inhibitor
3LAN 2010-02-23 2.55 Crystal structure of HIV-1 reverse transcriptase in complex with N1-butyl pyrimidinedione non-nucleoside inhibitor
5VQR 2017-08-23 2.55 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacrylamide (JLJ684), a Non-nucleoside Inhibitor
5TXO 2017-04-05 2.55 STRUCTURE OF Q151M complex (A62V, V75I, F77L, F116Y, Q151M) mutant HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP
6P1X 2019-07-24 2.55 Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and L-ddCTP
1RT1 1997-04-21 2.55 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH MKC-442
5VQT 2017-08-23 2.56 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 2-chloro-N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacetamide (JLJ686), a Non-nucleoside Inhibitor
4NCG 2014-02-12 2.58 Discovery of Doravirine, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses
5VQV 2017-08-23 2.58 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacrylamide (JLJ684), a Non-nucleoside Inhibitor
6ANQ 2018-08-15 2.59 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 8.5
3FFI 2009-12-15 2.6 HIV-1 RT with pyridone non-nucleoside inhibitor
6AN8 2018-08-15 2.6 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 8.0
1TKT 2004-12-07 2.6 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW426318
2ITG 1997-03-12 2.6 CATALYTIC DOMAIN OF HIV-1 INTEGRASE: ORDERED ACTIVE SITE IN THE F185H CONSTRUCT
3T19 2011-10-26 2.6 Crystal structure of HIV-1 reverse transcriptase (wild type) in complex with inhibitor M05
4ZHR 2015-11-11 2.6 Structure of HIV-1 RT Q151M mutant
1S9E 2004-05-11 2.6 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R129385
6IKA 2019-01-30 2.6 HIV-1 reverse transcriptase with Q151M/G112S/D113A/Y115F/F116Y/F160L/I159L:DNA:entecavir-triphosphate ternary complex
5C24 2015-07-29 2.6 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 7-((4-((4-cyanophenyl)amino)-1,3,5-triazin-2-yl)amino)-6,8-dimethylindolizine-2-carbonitrile (JLJ605), a non-nucleoside inhibitor
1S1V 2004-06-29 2.6 Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with TNK-651
6AXX 2018-09-12 2.6 Structure of the T58A/I124A mutant of the HIV-1 capsid protein
2R02 2007-12-18 2.6 Crystal Structure of ALIX/AIP1 in complex with the HIV-1 YPLTSL Late Domain
1JLF 2001-10-03 2.6 CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
1JLG 2001-10-03 2.6 CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH UC-781
1FB7 2000-12-13 2.6 CRYSTAL STRUCTURE OF AN IN VIVO HIV-1 PROTEASE MUTANT IN COMPLEX WITH SAQUINAVIR: INSIGHTS INTO THE MECHANISMS OF DRUG RESISTANCE
1BAJ 1998-10-14 2.6 HIV-1 CAPSID PROTEIN C-TERMINAL FRAGMENT PLUS GAG P2 DOMAIN
5XN0 2018-02-07 2.6 HIV-1 reverse transcriptase Q151M:DNA binary complex
4WYM 2014-12-17 2.6 Structural basis of HIV-1 capsid recognition by CPSF6
5VQU 2017-08-23 2.6 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-2-fluoro-N-methylacetamide (JLJ683), a Non-nucleoside Inhibitor
1REV 1996-10-14 2.6 HIV-1 REVERSE TRANSCRIPTASE
3DRP 2008-10-14 2.6 HIV reverse transcriptase in complex with inhibitor R8e
6AVT 2018-08-15 2.6 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 9.5 WITH CROSS-LINKING TO FIRST BASE TEMPLATE OVERHANG
1A43 1999-02-09 2.6 STRUCTURE OF THE HIV-1 CAPSID PROTEIN DIMERIZATION DOMAIN AT 2.6A RESOLUTION
6B2H 2018-09-26 2.6 P38A/T216I mutant of the HIV-1 capsid protein
3QO9 2011-05-04 2.6 Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with TSAO-T, a non-nucleoside RT inhibitor (NNRTI)
6ASW 2018-08-15 2.61 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 9.0
6GL1 2018-08-08 2.62 HLA-E*01:03 in complex with the HIV epitope, RL9HIV
1LWC 2002-10-30 2.62 CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
4RW6 2015-04-29 2.63 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) variant in complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor
5EU7 2016-09-28 2.64 Crystal structure of HIV-1 integrase catalytic core in complex with Fab
4DGC 2012-02-08 2.65 TRIMCyp cyclophilin domain from Macaca mulatta: cyclosporin A complex
4GW6 2013-05-01 2.65 HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor
3DI6 2008-08-19 2.65 HIV-1 RT with pyridazinone non-nucleoside inhibitor
6BSH 2018-01-03 2.65 Structure of HIV-1 RT complexed with RNA/DNA hybrid in the RNA hydrolysis mode
2B6A 2005-11-01 2.65 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with THR-50
3KLI 2010-09-22 2.65 Crystal structure of unliganded AZT-resistant HIV-1 Reverse Transcriptase
1KLM 1998-03-18 2.65 HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH BHAP U-90152
6OUN 2019-07-24 2.66 Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (-)3TC-TP
4RW4 2015-04-29 2.67 Crystal Structure of HIV-1 Reverse Transcriptase (K103N,Y181C) variant in complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor
5KGX 2016-10-19 2.67 HIV1 catalytic core domain in complex with an inhibitor (2~{S})-2-[3-(3,4-dihydro-2~{H}-chromen-6-yl)-1-methyl-indol-2-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid
3M8P 2010-05-19 2.67 HIV-1 RT with NNRTI TMC-125
4KSE 2014-08-13 2.68 Crystal structure of a HIV p51 (219-230) deletion mutant
6BHT 2018-08-01 2.69 HIV-1 CA hexamer in complex with IP6, orthorhombic crystal form
4LSL 2013-12-25 2.69 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-(4-chloro-2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ476), a non-nucleoside inhibitor
3PHV 1992-01-15 2.7 X-RAY ANALYSIS OF HIV-1 PROTEINASE AT 2.7 ANGSTROMS RESOLUTION CONFIRMS STRUCTURAL HOMOLOGY AMONG RETROVIRAL ENZYMES
1C0T 2000-07-19 2.7 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+21.1326
1HQE 2001-05-30 2.7 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
5TER 2017-01-11 2.7 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-chloro-7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-8-methyl-2-naphthonitrile (JLJ651), a Non-nucleoside Inhibitor
5TUQ 2017-06-28 2.7 Crystal Structure of a 6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione Inhibitor in Complex with HIV Reverse Transcriptase
1S1W 2004-06-29 2.7 Crystal structure of V106A mutant HIV-1 reverse transcriptase in complex with UC-781
3GGX 2009-05-26 2.7 HIV Protease, pseudo-symmetric inhibitors
3C6T 2008-04-22 2.7 Crystal Structure of HIV Reverse Transcriptase in complex with inhibitor 14
3QLH 2011-12-21 2.7 HIV-1 Reverse Transcriptase in Complex with Manicol at the RNase H Active Site and TMC278 (Rilpivirine) at the NNRTI Binding Pocket
6AN2 2018-08-15 2.7 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 7.5
3DS3 2008-09-02 2.7 HIV-1 capsid C-terminal domain mutant (Y169A) in complex with an inhibitor of particle assembly (CAI)
3KK1 2010-03-23 2.7 HIV-1 reverse transcriptase-DNA complex with nuceotide inhibitor GS-9148-diphosphate bound in nucleotide site
3M8Q 2010-05-19 2.7 HIV-1 RT with AMINOPYRIMIDINE NNRTI
4XFZ 2015-06-10 2.7 Structure of the native full-length HIV-1 capsid protein in complex with PF-3450074 (PF74)
3H4E 2009-06-23 2.7 X-ray Structure of Hexameric HIV-1 CA
3I0S 2009-08-25 2.7 crystal structure of HIV reverse transcriptase in complex with inhibitor 7
5TXM 2017-04-05 2.7 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DDATP
3C6U 2008-04-22 2.7 Crystal Structure of HIV Reverse Transcriptase in complex with inhibitor 22
2FDE 2006-02-21 2.7 Wild type HIV protease bound with GW0385
3V6D 2012-01-18 2.7 Crystal structure of HIV-1 reverse transcriptase (RT) cross-linked with AZT-terminated DNA
1HHP 1992-10-15 2.7 THE THREE-DIMENSIONAL STRUCTURE OF THE ASPARTYL PROTEASE FROM THE HIV-1 ISOLATE BRU
1HQU 2001-05-30 2.7 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
1DLO 1996-08-01 2.7 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
4I2Q 2013-01-16 2.7 Crystal structure of K103N/Y181C mutant of HIV-1 reverse transcriptase in complex with rilpivirine (TMC278) analogue
5TXP 2017-04-05 2.7 STRUCTURE OF Q151M complex (A62V, V75I, F77L, F116Y, Q151M) mutant HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DDATP
4O4G 2014-11-05 2.71 Crystal Structure of HIV-1 Reverse Transcriptase in complex with 4-((4-(mesitylamino)-1,3,5-triazin-2-yl)amino)benzonitrile (JLJ527), a non-nucleoside inhibitor
1EET 2001-02-07 2.73 HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH THE INHIBITOR MSC204
6DTW 2019-07-31 2.74 HIV-1 Reverse Transcriptase Y181C Mutant in complex with JLJ 578
6P1I 2019-07-24 2.74 Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and dCTP
5NMG 2017-11-15 2.75 868 TCR in complex with HLA A02 presenting SLYFNTIAVL
5HRO 2016-06-01 2.75 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A DNA aptamer and an Alpha-carboxy nucleoside phosphonate inhibitor (alpha-CNP)
6CQJ 2018-06-06 2.75 Crystal structure of DR1 presenting the RQ13 peptide
3LAM 2010-02-23 2.76 Crystal structure of HIV-1 reverse transcriptase in complex with N1-propyl pyrimidinedione non-nucleoside inhibitor
5O2U 2017-06-21 2.76 Llama VHH in complex with p24
6AXV 2018-09-12 2.77 Structure of the T58S/T107I/P122A mutant of the HIV-1 capsid protein in complex with PF-3450074 (PF74)
6AXY 2018-09-12 2.78 Structure of the V11I/T58A/I124A mutant of the HIV-1 capsid protein
5XOT 2017-06-14 2.79 Crystal structure of pHLA-B35 in complex with TU55 T cell receptor
5J2Q 2016-08-03 2.79 HIV-1 reverse transcriptase in complex with DNA that has incorporated a mismatched EFdA-MP at the N-(pre-translocation) site
3LP0 2010-06-09 2.79 HIV-1 reverse transcriptase with inhibitor
4DQG 2012-03-07 2.79 Crystal Structure of apo(G16C/L38C) HIV-1 Protease
1HTE 1994-07-31 2.8 X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE
4XFY 2015-06-10 2.8 Structure of the native full-length dehydrated HIV-1 capsid protein
1LWF 2002-10-30 2.8 CRYSTAL STRUCTURE OF A MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMQ+M184V: M41L/D67N/K70R/M184V/T215Y) IN COMPLEX WITH NEVIRAPINE
1M63 2002-09-25 2.8 Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
9HVP 1992-04-15 2.8 Design, activity and 2.8 Angstroms crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease
4U0B 2014-11-12 2.8 Hexamer HIV-1 CA in complex with CPSF6 peptide, P212121 crystal form
1EX4 2000-06-07 2.8 HIV-1 INTEGRASE CATALYTIC CORE AND C-TERMINAL DOMAIN
1IKX 2001-06-06 2.8 K103N Mutant HIV-1 Reverse Transcriptase in Complex with the Inhibitor PNU142721
2BPX 1999-02-23 2.8 HIV-1 protease-inhibitor complex
1TV6 2004-07-20 2.8 HIV-1 Reverse Transcriptase Complexed with CP-94,707
3LP3 2010-06-09 2.8 p15 HIV RNaseH domain with inhibitor MK3
3ITH 2010-03-16 2.8 Crystal structure of the HIV-1 reverse transcriptase bound to a 6-vinylpyrimidine inhibitor
3LP2 2010-06-09 2.8 HIV-1 reverse transcriptase with inhibitor
1BDR 1998-10-14 2.8 HIV-1 (2: 31, 33-37) PROTEASE COMPLEXED WITH INHIBITOR SB203386
2OPQ 2007-05-22 2.8 Crystal Structure of L100I Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
1BDL 1998-08-12 2.8 HIV-1 (2:31-37) PROTEASE COMPLEXED WITH INHIBITOR SB203386
1HNI 1995-06-03 2.8 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN A COMPLEX WITH THE NONNUCLEOSIDE INHIBITOR ALPHA-APA R 95845 AT 2.8 ANGSTROMS RESOLUTION
3HVP 1989-10-15 2.8 CONSERVED FOLDING IN RETROVIRAL PROTEASES. CRYSTAL STRUCTURE OF A SYNTHETIC HIV-1 PROTEASE
1LW0 2002-10-30 2.8 CRYSTAL STRUCTURE OF T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
1S1X 2004-06-29 2.8 Crystal structure of V108I mutant HIV-1 reverse transcriptase in complex with nevirapine
2BPW 1999-02-23 2.8 HIV-1 protease-inhibitor complex
3S85 2012-04-11 2.8 Discovery of New HIV Protease Inhibitors with Potential for Convenient Dosing and Reduced Side Effects: A-790742 and A-792611.
6CQQ 2018-06-06 2.8 Crystal structure of F24 TCR -DR15-RQ13 peptide complex
3IRX 2010-04-07 2.8 Crystal Structure of HIV-1 reverse transcriptase (RT) in complex with the Non-nucleoside RT Inhibitor (E)-S-Methyl 5-(1-(3,7-Dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-5-(5-methyl-1,3,4-oxadiazol-2-yl)pent-1-enyl)-2-methoxy-3-methylbenzothioate.
1DTQ 2000-03-20 2.8 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-1 (PETT131A94)
2HMI 1998-10-14 2.8 HIV-1 REVERSE TRANSCRIPTASE/FRAGMENT OF FAB 28/DNA COMPLEX
2WON 2010-08-11 2.8 Crystal Structure of UK-453061 bound to HIV-1 Reverse Transcriptase (wild-type).
3MEG 2010-05-12 2.8 HIV-1 K103N Reverse Transcriptase in Complex with TMC278
1RDH 1994-05-31 2.8 CRYSTALLOGRAPHIC ANALYSES OF AN ACTIVE HIV-1 RIBONUCLEASE H DOMAIN SHOW STRUCTURAL FEATURES THAT DISTINGUISH IT FROM THE INACTIVE FORM
1JLE 2001-10-03 2.8 CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE
1S9G 2004-05-11 2.8 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R120394.
3D3T 2008-07-08 2.8 Crystal Structure of HIV-1 CRF01_AE in complex with the substrate p1-p6
1TL3 2004-12-07 2.8 Crystal structure of hiv-1 reverse transcriptase in complex with gw450557
3IG1 2010-01-26 2.8 HIV-1 Reverse Transcriptase with the Inhibitor beta-Thujaplicinol Bound at the RNase H Active Site
3V4I 2012-01-18 2.8 Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and AZTTP
1R0A 2004-08-03 2.8 Crystal structure of HIV-1 reverse transcriptase covalently tethered to DNA template-primer solved to 2.8 angstroms
1RT6 1999-07-29 2.8 HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC38
2VG5 2007-12-11 2.8 Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors
1TKZ 2004-12-07 2.81 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW429576
1LWE 2002-10-30 2.81 CRYSTAL STRUCTURE OF M41L/T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMN) IN COMPLEX WITH NEVIRAPINE
6BHJ 2018-10-31 2.81 Structure of HIV-1 Reverse Transcriptase Bound to a 38-mer Hairpin Template-Primer RNA-DNA Aptamer
2VG7 2007-12-11 2.82 Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors
5C25 2015-07-29 2.84 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 6-((4-((4-cyanophenyl)amino)-1,3,5-triazin-2-yl)amino)-5,7-dimethyl-2-naphthonitrile (JLJ639), a Non-nucleoside Inhibitor
4H4M 2012-12-05 2.85 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor
3V81 2012-01-18 2.85 Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and the nonnucleoside inhibitor nevirapine
1QE1 1999-08-30 2.85 CRYSTAL STRUCTURE OF 3TC-RESISTANT M184I MUTANT OF HIV-1 REVERSE TRANSCRIPTASE
1TKX 2004-12-07 2.85 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745
5TW3 2017-03-15 2.85 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)-4-fluorophenoxy)-7-fluoro-2-naphthonitrile (JLJ636), a Non-nucleoside Inhibitor
6OTZ 2019-07-24 2.86 Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (+)FTC-TP
5V5M 2017-06-14 2.88 Crystal structure of HLA-B*5701 complex with HIV-1 gag derived peptide TW10
5INC 2016-10-05 2.88 Crystal structure of HLA-B5801, a protective HLA allele for HIV-1 infection
4RW8 2015-04-29 2.88 Crystal Structure of HIV-1 Reverse Transcriptase in complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ532), a non-nucleoside inhibitor'
4MFB 2013-11-06 2.88 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)indolizine-2-carbonitrile (JLJ555), a non-nucleoside inhibitor
6BSJ 2018-01-03 2.89 Structure of HIV-1 RT complexed with an RNA/DNA hybrid sequence non-preferred for RNA hydrolysis
4R5P 2015-03-11 2.89 Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and a nucleoside triphosphate mimic alpha-carboxy nucleoside phosphonate inhibitor
4O44 2014-05-21 2.89 Crystal Structure of HIV-1 Reverse Transcriptase in complex with 4-((4-(mesitylamino)-6-(3-morpholinopropoxy)-1,3,5-triazin-2-yl)amino)benzonitrile (JLJ529), a non-nucleoside inhibitor
5NMF 2017-11-15 2.89 868 TCR in complex with HLA A02 presenting SLYNTIATL
3DRR 2008-10-14 2.89 HIV reverse transcriptase Y181C mutant in complex with inhibitor R8e
4KKO 2013-08-14 2.89 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 4-((4-methoxy-6-(2-morpholinoethoxy)-1,3,5-triazin-2-yl)amino)-2-((3-methylbut-2-en-1-yl)oxy)benzonitrile (JLJ513), a non-nucleoside inhibitor
1TL1 2004-12-07 2.9 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW451211
6OE3 2019-05-15 2.9 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-7-fluoro-2-naphthonitrile (JLJ635), a Non-nucleoside Inhibitor
2YNH 2013-01-09 2.9 HIV-1 Reverse Transcriptase in complex with inhibitor GSK500
3HVT 1994-10-15 2.9 STRUCTURAL BASIS OF ASYMMETRY IN THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE HETERODIMER
1FKP 2000-11-03 2.9 CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
1S6P 2004-05-11 2.9 CRYSTAL STRUCTURE OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R100943
3DOK 2008-08-12 2.9 Crystal structure of K103N mutant HIV-1 reverse transcriptase in complex with GW678248.
2ZE2 2008-02-12 2.9 Crystal structure of L100I/K103N mutant HIV-1 reverse transcriptase (RT) in complex with TMC278 (rilpivirine), a non-nucleoside RT inhibitor
5J1E 2016-06-15 2.9 Crystal Structure of a Hydroxypyridone Carboxylic Acid Active-Site RNase H Inhibitor in Complex with HIV Reverse Transcriptase
5J2N 2016-08-03 2.9 HIV-1 reverse transcriptase in complex with DNA that has incorporated EFdA-MP at the P-(post-translocation) site and dTMP at the N-(pre-translocation) site
1FKO 2000-11-03 2.9 CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
3KK2 2010-03-23 2.9 HIV-1 reverse transcriptase-DNA complex with dATP bound in the nucleotide binding site
1RT4 1999-07-29 2.9 HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC781
2B5J 2005-12-06 2.9 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with JANSSEN-R165481
5HP1 2016-06-01 2.9 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A DNA aptamer and FOSCARNET, a Pyrophosphate analog
3KK3 2010-03-23 2.9 HIV-1 reverse transcriptase-DNA complex with GS-9148 terminated primer
4PUO 2014-06-18 2.9 Crystal structure of HIV-1 reverse transcriptase in complex with RNA/DNA and Nevirapine
2YKM 2011-08-17 2.9 Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with a Difluoromethylbenzoxazole (DFMB) Pyrimidine Thioether derivative, a non-nucleoside RT inhibitor (NNRTI)
1SV5 2004-05-11 2.9 CRYSTAL STRUCTURE OF K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R165335
3KLH 2010-09-22 2.9 Crystal structure of AZT-Resistant HIV-1 Reverse Transcriptase crosslinked to post-translocation AZTMP-Terminated DNA (COMPLEX P)
1RT5 1999-07-29 2.9 HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC10
4H4O 2012-12-05 2.9 Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with (E)-3-(3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)- 4-fluorophenoxy)-5-fluorophenyl)acrylonitrile (JLJ506), A Non-nucleoside inhibitor
2OPR 2007-05-22 2.9 Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
1KJ4 2002-03-06 2.9 SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES
6BHR 2018-08-08 2.91 HIV-1 immature CTD-SP1 hexamer in complex with IP6
5NME 2017-11-15 2.94 868 TCR in complex with HLA A02 presenting SLYNTVATL
5HLF 2016-02-10 2.95 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A 38-MER HAIRPIN TEMPLATE-PRIMER DNA APTAMER AND AN ALPHA-CARBOXYPHOSPHONATE INHIBITOR
2BAN 2005-12-06 2.95 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with JANSSEN-R157208
3E01 2008-11-25 2.95 HIV-RT with non-nucleoside inhibitor annulated pyrazole 2
3NBP 2010-08-18 2.95 HIV-1 reverse transcriptase with aminopyrimidine inhibitor 2
3I0R 2009-08-25 2.98 crystal structure of HIV reverse transcriptase in complex with inhibitor 3
4RW9 2015-04-29 2.99 Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) variant in complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ532), a non-nucleoside inhibitor
6P2G 2019-07-24 2.99 Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and D-ddCTP
1DTT 2000-04-02 3.0 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-2 (PETT130A94)
1AUM 1998-01-14 3.0 HIV CAPSID C-TERMINAL DOMAIN (CAC146)
2HVP 1989-04-19 3.0 THREE-DIMENSIONAL STRUCTURE OF ASPARTYL PROTEASE FROM HUMAN IMMUNODEFICIENCY VIRUS HIV-1
1S6Q 2004-05-11 3.0 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R147681
1LW2 2002-10-30 3.0 CRYSTAL STRUCTURE OF T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH 1051U91
2HNZ 2006-09-05 3.0 Crystal Structure of E138K Mutant HIV-1 Reverse Transcriptase in Complex with PETT-2
1JLQ 2001-08-22 3.0 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH 739W94
5I3U 2016-06-01 3.0 STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE N-SITE COMPLEX; CATALYTIC INCORPORATION OF AZTMP to A DNA aptamer in CRYSTAL
1T05 2004-05-11 3.0 HIV-1 reverse transcriptase crosslinked to template-primer with tenofovir-diphosphate bound as the incoming nucleotide substrate
1JLB 2001-10-03 3.0 CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
1SUQ 2004-05-11 3.0 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R185545
3JSM 2009-09-29 3.0 K65R mutant HIV-1 reverse transcriptase cross-linked to DS-DNA and complexed with tenofovir-diphosphate as the incoming nucleotide substrate
1RT7 1999-07-29 3.0 HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC84
6N3J 2018-12-12 3.0 MicroED Structure of the CTD-SP1 fragment of HIV-1 Gag
1IKV 2001-06-06 3.0 K103N Mutant HIV-1 Reverse Transcriptase in Complex with Efivarenz
1RTI 1996-04-03 3.0 HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
1JLC 2001-10-03 3.0 CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-2
1HPZ 2001-05-30 3.0 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
1RT3 1999-02-16 3.0 AZT DRUG RESISTANT HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH 1051U91
1HYS 2001-03-26 3.0 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A POLYPURINE TRACT RNA:DNA
1E28 2000-09-12 3.0 Nonstandard peptide binding of HLA-B*5101 complexed with HIV immunodominant epitope KM2(TAFTIPSI)
4PWD 2014-06-18 3.0 Crystal structure of HIV-1 reverse transcriptase in complex with bulge-RNA/DNA and Nevirapine
1N6Q 2003-01-14 3.0 HIV-1 Reverse Transcriptase Crosslinked to pre-translocation AZTMP-terminated DNA (complex N)
1S1U 2004-06-29 3.0 Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with nevirapine
5W5W 2018-06-20 3.0 HIV Protease (PR) in open form with Mg2+ in active site and HIVE-9 in eye site
2IC3 2006-12-19 3.0 Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with Nonnucleoside Inhibitor HBY 097
2UPJ 1996-10-14 3.0 HIV-1 PROTEASE COMPLEX WITH U100313 ([3-[[3-[CYCLOPROPYL [4-HYDROXY-2OXO-6-[1-(PHENYLMETHYL)PROPYL]-2H-PYRAN-3-YL] METHYL]PHENYL]AMINO]-3-OXO-PROPYL]CARBAMIC ACID TERT-BUTYL ESTER)
1TVR 1997-03-12 3.0 HIV-1 RT/9-CL TIBO
4U0D 2014-11-12 3.0 Hexameric HIV-1 CA in complex with Nup153 peptide, P212121 crystal form
1HNV 1995-07-10 3.0 STRUCTURE OF HIV-1 RT(SLASH)TIBO R 86183 COMPLEX REVEALS SIMILARITY IN THE BINDING OF DIVERSE NONNUCLEOSIDE INHIBITORS
1IKW 2001-06-06 3.0 Wild Type HIV-1 Reverse Transcriptase in Complex with Efavirenz
1YT9 2005-04-12 3.0 HIV Protease with oximinoarylsulfonamide bound
5UV5 2017-08-16 3.0 Crystal Structure of a 2-Hydroxyisoquinoline-1,3-dione RNase H Active Site Inhibitor with Multiple Binding Modes to HIV Reverse Transcriptase
1IKY 2001-06-06 3.0 HIV-1 Reverse Transcriptase in Complex with the Inhibitor MSC194
4RW7 2015-04-29 3.01 Crystal Structure of HIV-1 Reverse Transcriptase (K103N, Y181C) variant in complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ532), a non-nucleoside inhibitor
2VG6 2007-12-11 3.01 Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors
6CQR 2018-06-06 3.04 Crystal structure of F24 TCR -DR1-RQ13 peptide complex
5HBM 2016-02-24 3.04 Crystal Structure of a Dihydroxycoumarin RNase H Active-Site Inhibitor in Complex with HIV-1 Reverse Transcriptase
3GGV 2009-05-26 3.09 HIV Protease, pseudo-symmetric inhibitors
1FQX 2001-03-14 3.1 CRYSTAL STRUCTURE OF THE COMPLEX OF HIV-1 PROTEASE WITH A PEPTIDOMIMETIC INHIBITOR
1N5Y 2003-01-28 3.1 HIV-1 Reverse Transcriptase Crosslinked to Post-Translocation AZTMP-Terminated DNA (Complex P)
5HGL 2016-08-10 3.1 Hexameric HIV-1 CA, open conformation
5FDL 2016-02-17 3.1 Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with IDX899
3KJV 2010-03-23 3.1 HIV-1 reverse transcriptase in complex with DNA
1BQM 1999-01-06 3.1 HIV-1 RT/HBY 097
3W39 2013-02-13 3.1 Crystal structure of HLA-B*5201 in complexed with HIV immunodominant epitope (TAFTIPSI)
1MF8 2002-10-16 3.1 Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin
1T03 2004-05-11 3.1 HIV-1 reverse transcriptase crosslinked to tenofovir terminated template-primer (complex P)
4LSN 2013-12-25 3.1 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-bromo-5-(4-chloro-2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ518), a non-nucleoside inhibitor
5TEP 2017-01-11 3.1 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ649), a Non-nucleoside Inhibitor
3KLF 2010-09-22 3.15 Crystal structure of wild-type HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA
3DRS 2008-10-14 3.15 HIV reverse transcriptase K103N mutant in complex with inhibitor R8D
2I5J 2006-12-05 3.15 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with DHBNH, an RNASE H inhibitor
2WOM 2010-08-11 3.2 Crystal Structure of UK-453061 bound to HIV-1 Reverse Transcriptase (K103N).
3KLE 2010-09-22 3.2 Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA
1RTD 1998-12-09 3.2 STRUCTURE OF A CATALYTIC COMPLEX OF HIV-1 REVERSE TRANSCRIPTASE: IMPLICATIONS FOR NUCLEOSIDE ANALOG DRUG RESISTANCE
6MQA 2019-06-19 3.2 Structure of HIV-1 CA P207S
1HMV 1995-03-31 3.2 THE STRUCTURE OF UNLIGANDED REVERSE TRANSCRIPTASE FROM THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
6MQO 2019-06-19 3.2 Structure of HIV-1 CA G208R
1UWB 1997-05-15 3.2 TYR 181 CYS HIV-1 RT/8-CL TIBO
6BSI 2018-01-03 3.25 Structure of HIV-1 RT complexed with an RNA/DNA hybrid containing the polypurine-tract sequence
4B3O 2013-01-16 3.3 Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface
6MQP 2019-06-19 3.3 Structure of HIV-1 CA T210K
5I42 2016-06-01 3.3 Structure of HIV-1 Reverse Transcriptase in complex with a DNA aptamer, AZTTP, and CA(2+) ion
4Q0B 2014-06-18 3.3 Crystal structure of HIV-1 reverse transcriptase in complex with gap-RNA/DNA and Nevirapine
3JYT 2009-10-06 3.3 K65R mutant HIV-1 reverse transcriptase cross-linked to DS-DNA and complexed with DATP as the incoming nucleotide substrate
1BQN 1999-01-06 3.3 TYR 188 LEU HIV-1 RT/HBY 097
6DTX 2019-07-31 3.33 Wildtype HIV-1 Reverse Transcriptase in complex with JLJ 578
6BJ2 2018-07-25 3.35 TCR589 in complex with HIV(Pol448-456)/HLA-B35
1P7Q 2003-10-14 3.4 Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor
6EC2 2019-08-21 3.4 Structure of HIV-1 CA 1/3-hexamer
6ECN 2019-08-21 3.4 HIV-1 CA 1/2-hexamer-EE
1J5O 2002-06-14 3.5 CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE-PRIMER
5C42 2015-11-11 3.5 Crystal Structure of HIV-1 Reverse Transcriptase (K101P) Variant in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)indolizine-2-carbonitrile (JLJ555), a non-nucleoside inhibitor
3KLG 2010-09-22 3.65 Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to pre-translocation AZTMP-Terminated DNA (COMPLEX N)
1AFV 1997-08-20 3.7 HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3
5L93 2016-07-13 3.9 An atomic model of HIV-1 CA-SP1 reveals structures regulating assembly and maturation
5U1C 2017-01-11 3.9 Structure of tetrameric HIV-1 Strand Transfer Complex Intasome
6HAK 2019-04-03 3.95 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with a double stranded RNA represents the RT transcription initiation complex prior to nucleotide incorporation
3DTJ 2008-09-02 4.0 HIV-1 capsid C-terminal domain mutant (E187A)
6ECO 2019-09-18 4.2 Hexamer-2-Foldon HIV-1 capsid platform
6B19 2018-04-25 4.5 Architecture of HIV-1 reverse transcriptase initiation complex core
1HVU 1999-01-13 4.75 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE COMPLEXED WITH A 33-BASE NUCLEOTIDE RNA PSEUDOKNOT
4B3P 2013-01-16 4.84 Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface
4B3Q 2013-01-16 5.0 Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface
5UPW 2017-03-01 5.0 CryoEM Structure Refinement by Integrating NMR Chemical Shifts with Molecular Dynamics Simulations
5KP9 2016-12-07 5.7 Structure of Nanoparticle Released from Enveloped Protein Nanoparticle
3P0A 2011-01-12 5.95 X-ray structure of pentameric HIV-1 CA
3GV2 2009-06-23 7.0 X-ray Structure of Hexameric HIV-1 CA
5FJB 2016-03-16 9.0 Cyclophilin A Stabilize HIV-1 Capsid through a Novel Non- canonical Binding Site

Relevant UniProtKB Entries

Percent Identity Matching Chains Protein Accession Entry Name
200.0 A,B Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P62938 PPIA_CHLAE
200.0 A,B Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q0ZQL0 PPIA_GORGO
200.0 A,B Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P62937 PPIA_HUMAN
200.0 A,B Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q0ZQK8 PPIA_HYLLA
200.0 A,B Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P62940 PPIA_MACMU
200.0 A,B Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q0ZQK7 PPIA_NOMLE
200.0 A,B Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q0ZQL2 PPIA_PANPA
200.0 A,B Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q0ZQL1 PPIA_PANTR
200.0 A,B Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P62941 PPIA_PAPAN
200.0 A,B Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q5R8S7 PPIA_PONPY
200.0 A,B Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q0ZQK6 PPIA_SYMSY
197.6 A,B Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P62935 PPIA_BOVIN
197.6 A,B Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P62936 PPIA_PIG
197.6 A,B Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q6DTV9 PPIA_AOTTR
197.6 A,B Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q0ZQK3 PPIA_SAGOE
194.0 A,B Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q8HXS3 PPIA_FELCA
194.0 A,B Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P14851 PPIA_CRIGR
192.6 A,B Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q9TTC6 PPIA_RABIT
192.6 A,B Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P17742 PPIA_MOUSE
192.6 A,B Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P10111 PPIA_RAT
200.0 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P12493 GAG_HV1N5
200.0 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P12497 POL_HV1N5
198.6 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P05890 GAG_HV1RH
198.6 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P05889 GAG_HV1W2
198.6 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P35962 GAG_HV1Y2
198.6 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P05959 POL_HV1RH
198.6 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P35963 POL_HV1Y2
197.2 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P20873 GAG_HV1JR
197.2 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P20875 POL_HV1JR
197.2 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P03349 GAG_HV1A2
197.2 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P03369 POL_HV1A2
195.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P03347 GAG_HV1B1
195.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P04593 GAG_HV1B5
195.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P03348 GAG_HV1BR
195.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P04591 GAG_HV1H2
195.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q70622 GAG_HV1LW
195.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P03366 POL_HV1B1
195.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P04587 POL_HV1B5
195.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P03367 POL_HV1BR
195.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P04585 POL_HV1H2
195.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P0C6F2 POL_HV1LW
195.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P05888 GAG_HV1MN
195.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P20889 GAG_HV1OY
195.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P20892 POL_HV1OY
194.4 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P05887 GAG_HV1C4
195.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P12495 GAG_HV1Z2
194.4 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P05960 POL_HV1C4
194.4 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P05961 POL_HV1MN
195.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P12499 POL_HV1Z2
194.4 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q73367 GAG_HV1B9
194.4 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q73368 POL_HV1B9
194.4 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P04592 GAG_HV1EL
194.4 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P04589 POL_HV1EL
193.2 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P18800 GAG_HV1ND
193.2 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P18802 POL_HV1ND
194.4 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P12494 GAG_HV1J3
194.4 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P12498 POL_HV1J3
189.0 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q9WC53 GAG_HV1S2
189.0 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q9WC54 POL_HV1S2
189.0 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q9QBZ6 GAG_HV1MP
189.0 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q9QBZ5 POL_HV1MP
187.6 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q9QBY4 GAG_HV196
187.6 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q9QBZ2 GAG_HV1M2
187.6 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q9QBY3 POL_HV196
187.6 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q9QBZ1 POL_HV1M2
186.2 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q9WC62 GAG_HV1S9
186.2 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q9WC63 POL_HV1S9
189.0 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q9Q721 GAG_HV1V9
189.0 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q9Q720 POL_HV1V9
187.6 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein O12157 GAG_HV192
187.6 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein O12158 POL_HV192
187.6 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q9QC00 GAG_HV197
187.6 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q9QBZ9 POL_HV197
184.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q75001 GAG_HV1ET
184.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P04594 GAG_HV1MA
184.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q75002 POL_HV1ET
184.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P04588 POL_HV1MA
184.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q9QSR4 GAG_HV1VI
184.8 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q9QSR3 POL_HV1VI
187.6 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein O93182 GAG_HV190
187.6 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein O93215 POL_HV190
183.4 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q1A268 GAG_SIVMB
183.4 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein Q1A267 POL_SIVMB
183.4 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein O89291 GAG_HV193
183.4 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein O89290 POL_HV193
183.4 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P24736 GAG_HV1U4
183.4 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P24740 POL_HV1U4
182.0 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein P0C1K7 GAG_HV19N
182.0 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein O89939 GAG_HV1SE
182.0 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein O41798 POL_HV19N
182.0 C,D Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein O89940 POL_HV1SE