Molecular recognition in the HIV-1 capsid/cyclophilin A complex.
Abstract
The HIV-1 capsid protein (CA) makes an essential interaction with the human peptidyl prolyl isomerase, cyclophilin A (CypA), that results in packaging of CypA into the virion at a CA to CypA stoichiometry of approximately 10:1. The 231 amino acid residue capsid protein is composed of an amino-terminal CypA binding domain (1 to approximately 151; CA151) and a carboxyl-terminal dimerization domain (approximately 151 to 231). We find that CypA binds dimeric CA and monomeric CA151 with identical intrinsic affinities (K[d] = 16(+/-4) microM). This result demonstrates that capsid dimerization and cyclophilin A binding are not thermodynamically coupled and suggests that the substoichiometric ratio of CypA in the HIV-1 virion results from the intrinsic stability of the CA/CypA complex. In the known co-crystal structure of the CA151/CypA complex, CypA binding is mediated exclusively by an exposed capsid loop that spans residues Pro85 to Pro93. The energetic contributions to CypA binding were quantified for each residue in this loop, and the results demonstrate that the Gly89-Pro90 dipeptide is the primary cyclophilin A recognition motif, with Pro85, Val86, His87, Ala88, and Pro93 also making energetically favorable contacts. These studies reveal that the active site of CypA, which can catalyze the isomerization of proline residues in vitro, also functions as a sequence-specific, protein-binding motif in HIV-1 replication.
Submission Details
ID: AXsUwn94
Submitter: Shu-Ching Ou
Submission Date: Feb. 22, 2019, 12:13 p.m.
Version: 1
Publication Details
Yoo S;Myszka DG;Yeh C;McMurray M;Hill CP;Sundquist WI,J Mol Biol (1997) Molecular recognition in the HIV-1 capsid/cyclophilin A complex. PMID:9223641Additional Information
Two sets of ΔΔG values are reported. One is from direct calculations using relative Kd, and the other set is reported from the AB-Bind article (DOI: 10.1002/pro.2829)
Study Summary
| Number of data points | 84 |
| Proteins | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein |
| Unique complexes | 17 |
| Assays/Quantities/Protocols | Experimental Assay: Kd ; Derived Quantity: ΔΔG_AB-Bind ; Derived Quantity: ΔΔG ; Derived Quantity: Fold decrease in Kd ; Derived Quantity: SD of Kd |
| Libraries | Variants for CypA-CA |
Structure view and single mutant data analysis
Study data
| Colors: | D | E | R | H | K | S | T | N | Q | A | V | I | L | M | F | Y | W | C | G | P |
|---|
Data Distribution
Studies with similar sequences (approximate matches)
Correlation with other assays (exact sequence matches)
Relevant PDB Entries
| Structure ID | Release Date | Resolution | Structure Title |
|---|---|---|---|
| 3DIK | 2008-09-16 | Pseudo-atomic model of the HIV-1 CA hexameric lattice | |
| 1GWP | 2002-06-21 | STRUCTURE OF THE N-TERMINAL DOMAIN OF THE MATURE HIV-1 CAPSID PROTEIN | |
| 6N3U | 2018-12-12 | MicroED Structure of the CTD-SP1 fragment of HIV-1 Gag with bound maturation inhibitor Bevirimat. | |
| 1ESK | 2000-04-26 | SOLUTION STRUCTURE OF NCP7 FROM HIV-1 | |
| 1BVG | 1996-08-17 | HIV-1 PROTEASE-DMP323 COMPLEX IN SOLUTION, NMR MINIMIZED AVERAGE STRUCTURE | |
| 2HMX | 1996-01-29 | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 MATRIX PROTEIN | |
| 2M8L | 2013-11-20 | HIV capsid dimer structure | |
| 1UPH | 2004-01-08 | HIV-1 Myristoylated Matrix | |
| 2M8P | 2013-11-20 | The structure of the W184AM185A mutant of the HIV-1 capsid protein | |
| 2N0T | 2015-08-26 | Structural ensemble of the enzyme cyclophilin reveals an orchestrated mode of action at atomic resolution | |
| 2L6E | 2010-12-29 | NMR Structure of the monomeric mutant C-terminal domain of HIV-1 Capsid in complex with stapled peptide Inhibitor | |
| 1BVE | 1996-08-17 | HIV-1 PROTEASE-DMP323 COMPLEX IN SOLUTION, NMR, 28 STRUCTURES | |
| 6X63 | 2020-09-02 | Atomic-Resolution Structure of HIV-1 Capsid Tubes by Magic Angle Spinning NMR | |
| 5T82 | 2017-01-18 | HIV-1 reverse transcriptase thumb subdomain | |
| 1OCA | 1997-11-19 | HUMAN CYCLOPHILIN A, UNLIGATED, NMR, 20 STRUCTURES | |
| 1TAM | 1996-07-11 | HUMAN IMMUNODEFICIENCY VIRUS, NMR, MINIMIZED AVERAGE STRUCTURE | |
| 1WJE | 1998-12-16 | SOLUTION STRUCTURE OF H12C MUTANT OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE COMPLEXED TO CADMIUM, NMR, MINIMIZED AVERAGE STRUCTURE | |
| 2JZW | 2009-01-13 | How the HIV-1 nucleocapsid protein binds and destabilises the (-)primer binding site during reverse transcription | |
| 1WJA | 1998-05-13 | SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (D FORM), NMR, REGULARIZED MEAN STRUCTURE | |
| 5I1R | 2016-03-30 | Quantitative characterization of configurational space sampled by HIV-1 nucleocapsid using solution NMR and X-ray scattering | |
| 2EXF | 2007-04-24 | Solution structure of the HIV-1 nucleocapsid (NCp7(12-55)) complexed with the DNA (-) Primer Binding Site | |
| 1MFS | 1998-06-17 | DYNAMICAL BEHAVIOR OF THE HIV-1 NUCLEOCAPSID PROTEIN; NMR, 30 STRUCTURES | |
| 2H3Q | 2006-07-25 | Solution structure of HIV-1 myrMA bound to di-C4-phosphatidylinositol-(4,5)-bisphosphate | |
| 5IRT | 2016-06-22 | Dimerization interface of the noncrystalline HIV-1 capsid protein lattice from solid state NMR spectroscopy of tubular assemblies | |
| 2JPR | 2007-10-09 | Joint refinement of the HIV-1 CA-NTD in complex with the assembly inhibitor CAP-1 | |
| 1U57 | 2005-02-08 | NMR structure of the (345-392)Gag sequence from HIV-1 | |
| 2MZU | 2015-04-22 | Extending the eNOE data set of large proteins by evaluation of NOEs with unresolved diagonals | |
| 2L46 | 2011-12-14 | C-terminal zinc finger of the HIVNCp7 with platinated DNA | |
| 2KOD | 2009-11-24 | A high-resolution NMR structure of the dimeric C-terminal domain of HIV-1 CA | |
| 1F6U | 2000-10-09 | NMR structure of the HIV-1 nucleocapsid protein bound to stem-loop sl2 of the psi-RNA packaging signal. Implications for genome recognition | |
| 2L45 | 2011-12-14 | C-terminal zinc knuckle of the HIVNCp7 with DNA | |
| 4JEC | 2013-07-24 | Joint neutron and X-ray structure of per-deuterated HIV-1 protease in complex with clinical inhibitor amprenavir | |
| 1WJD | 1998-05-13 | SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (E FORM), NMR, 38 STRUCTURES | |
| 2M3Z | 2013-02-27 | NMR solution structure of HIV-1 nucleocapsid protein in complex with an inhibitor displaying a 2 inhibitors:1 NC stoichiometry | |
| 6WAP | 2020-09-02 | Atomic-Resolution Structure of HIV-1 Capsid Tubes by Magic Angle Spinning NMR | |
| 1QMC | 1999-12-14 | C-terminal DNA-binding domain of HIV-1 integrase, NMR, 42 structures | |
| 2LF4 | 2011-11-09 | Structure of a monomeric mutant of the HIV-1 capsid protein | |
| 1Q9P | 2004-03-02 | Solution structure of the mature HIV-1 protease monomer | |
| 1HVN | 1994-01-31 | ZINC-AND SEQUENCE-DEPENDENT BINDING TO NUCLEIC ACIDS BY THE N-TERMINAL ZINC FINGER DOMAIN OF THE HIV-1 NUCLEOCAPSID PROTEIN: NMR STRUCTURE OF THE COMPLEX WITH THE PSI-SITE ANALOG, D/ACGCC | |
| 1WJF | 1998-12-16 | SOLUTION STRUCTURE OF H12C MUTANT OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE COMPLEXED TO CADMIUM, NMR, 40 STRUCTURES | |
| 6RWG | 2020-05-20 | Structure of HIV-1 CAcSP1NC mutant(W41A,M42A) interacting with maturation inhibitor EP39 | |
| 2MGU | 2014-02-12 | Structure of the complex between calmodulin and the binding domain of HIV-1 matrix protein | |
| 2JYG | 2008-02-26 | Solution Structure of the W184A/M185A Mutant of the Carboxy-terminal Dimerization Domain of the HIV-1 Capsid Protein | |
| 2H3Z | 2006-07-25 | Structure of the HIV-1 matrix protein bound to di-C4-phosphatidylinositol-(4,5)-bisphosphate | |
| 2H3F | 2006-07-25 | Solution structure of the HIV-1 MA protein | |
| 5E5K | 2016-05-04 | Joint X-ray/neutron structure of HIV-1 protease triple mutant (V32I,I47V,V82I) with darunavir at pH 4.3 | |
| 2M8N | 2013-11-20 | HIV-1 capsid monomer structure | |
| 1WJC | 1998-05-13 | SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (E FORM), NMR, REGULARIZED MEAN STRUCTURE | |
| 3CYS | 1994-08-31 | DETERMINATION OF THE NMR SOLUTION STRUCTURE OF THE CYCLOPHILIN A-CYCLOSPORIN A COMPLEX | |
| 2LYA | 2013-02-13 | Structure of HIV-1 myr(-) matrix protein in complex with 1,2-dioctanoyl-sn-phosphatidylcholine | |
| 1HVO | 1994-01-31 | ZINC-AND SEQUENCE-DEPENDENT BINDING TO NUCLEIC ACIDS BY THE N-TERMINAL ZINC FINGER DOMAIN OF THE HIV-1 NUCLEOCAPSID PROTEIN: NMR STRUCTURE OF THE COMPLEX WITH THE PSI-SITE ANALOG, D/ACGCC | |
| 2JYL | 2008-02-12 | Solution Structure of A Double Mutant of The Carboxy-terminal Dimerization Domain of The HIV-1 Capsid Protein | |
| 2MS4 | 2015-09-09 | Cyclophilin a complexed with a fragment of crk-ii | |
| 2LYB | 2013-02-13 | Structure of HIV-1 myr(-) matrix protein in complex with 1,2-dioctanoyl-sn-phosphatidyl-L-serine | |
| 1NCP | 1993-10-31 | STRUCTURAL CHARACTERIZATION OF A 39 RESIDUE SYNTHETIC PEPTIDE CONTAINING THE TWO ZINC BINDING DOMAINS FROM THE HIV-1 P7 NUCLEOCAPSID PROTEIN BY CD AND NMR SPECTROSCOPY | |
| 1O1W | 2003-02-18 | SOLUTION STRUCTURE OF THE RNASE H DOMAIN OF THE HIV-1 REVERSE TRANSCRIPTASE IN THE PRESENCE OF MAGNESIUM | |
| 2H3V | 2006-07-25 | Structure of the HIV-1 Matrix protein bound to di-C8-phosphatidylinositol-(4,5)-bisphosphate | |
| 2C55 | 2005-11-02 | Solution Structure of the Human Immunodeficiency Virus Type 1 p6 Protein | |
| 1AAF | 1994-01-31 | NUCLEOCAPSID ZINC FINGERS DETECTED IN RETROVIRUSES: EXAFS STUDIES ON INTACT VIRUSES AND THE SOLUTION-STATE STRUCTURE OF THE NUCLEOCAPSID PROTEIN FROM HIV-1 | |
| 2L4L | 2010-12-08 | Structural insights into the cTAR DNA recognition by the HIV-1 Nucleocapsid protein: role of sugar deoxyriboses in the binding polarity of NC | |
| 1WJB | 1998-05-13 | SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (D FORM), NMR, 40 STRUCTURES | |
| 2H3I | 2006-07-25 | Solution structure of the HIV-1 myristoylated Matrix protein | |
| 5YOK | 2018-07-18 | 0.85 | Structure of HIV-1 Protease in Complex with Inhibitor KNI-1657 |
| 3A2O | 2010-03-02 | 0.88 | Crystal Structure of HIV-1 Protease Complexed with KNI-1689 |
| 3FX5 | 2009-03-24 | 0.93 | Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by High Resolution X-ray Crystallography |
| 3DJK | 2008-09-30 | 1.0 | Wild Type HIV-1 Protease with potent Antiviral inhibitor GRL-0255A |
| 3NU3 | 2010-08-25 | 1.02 | Wild Type HIV-1 Protease with Antiviral Drug Amprenavir |
| 3NDX | 2011-07-20 | 1.03 | HIV-1 Protease Saquinavir:Ritonavir 1:50 complex structure |
| 1NH0 | 2004-04-13 | 1.03 | 1.03 A structure of HIV-1 protease: inhibitor binding inside and outside the active site |
| 2J9J | 2007-08-28 | 1.04 | Atomic-resolution Crystal Structure of Chemically-Synthesized HIV-1 Protease Complexed with Inhibitor JG-365 |
| 3D1Y | 2008-05-27 | 1.05 | Crystal structure of HIV-1 mutant I54V and inhibitor SAQUINA |
| 3BVA | 2008-04-01 | 1.05 | Cystal structure of HIV-1 Active Site Mutant D25N and p2-NC analog inhibitor |
| 3D20 | 2008-05-27 | 1.05 | Crystal structure of HIV-1 mutant I54V and inhibitor DARUNAVIA |
| 3D1X | 2008-06-03 | 1.05 | Crystal structure of HIV-1 mutant I54M and inhibitor saquinavir |
| 4HE9 | 2013-08-21 | 1.06 | Crystal Structure of HIV-1 protease mutants I54M complexed with inhibitor GRL-0519 |
| 2JE4 | 2007-08-28 | 1.07 | Atomic-resolution crystal structure of chemically-synthesized HIV-1 protease in complex with JG-365 |
| 3DK1 | 2009-05-12 | 1.07 | Wild Type HIV-1 Protease with potent Antiviral inhibitor GRL-0105A |
| 1KZK | 2002-04-03 | 1.09 | JE-2147-HIV Protease Complex |
| 2AVO | 2006-01-24 | 1.1 | Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S |
| 2AVS | 2006-01-24 | 1.1 | kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, and G73S |
| 2AVM | 2006-01-24 | 1.1 | Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S |
| 2AOG | 2006-01-17 | 1.1 | Crystal structure analysis of HIV-1 protease mutant V82A with a substrate analog P2-NC |
| 4EJD | 2013-05-01 | 1.1 | HIV Protease (PR) dimer in closed form with pepstatin in active site and fragment 1F1 in the outside/top of flap |
| 2QD7 | 2008-04-22 | 1.11 | HIV-1 Protease Mutant V82A with potent Antiviral inhibitor GRL-98065 |
| 4ZIP | 2015-07-15 | 1.11 | HIV-1 wild Type protease with GRL-0648A (a isophthalamide-derived P2-Ligand) |
| 3DS4 | 2008-09-02 | 1.12 | HIV-1 capsid C-terminal domain mutant (L211S) in complex with an inhibitor of particle assembly (CAI) |
| 3TOH | 2012-08-15 | 1.12 | HIV-1 Protease - Epoxydic Inhibitor Complex (pH 9 - Orthorombic Crystal form P212121) |
| 6DV4 | 2018-10-31 | 1.14 | HIV-1 wild type protease with GRL-04315A, a tetrahydronaphthalene carboxamide with (R)-Boc-amine and (S)-hydroxyl functionalities as the P2 ligand |
| 3NDW | 2011-07-20 | 1.14 | HIV-1 Protease Saquinavir:Ritonavir 1:15 complex structure |
| 5F66 | 2015-12-30 | 1.15 | High-resolution isotropic multiconformer synchrotron model of CypA at 273 K |
| 4N1M | 2015-08-12 | 1.15 | Structure of Cyclophilin A in complex with GlyPro. |
| 3NU6 | 2010-08-25 | 1.16 | Crystal Structure of HIV-1 Protease Mutant I54M with Antiviral Drug Amprenavir |
| 6GS6 | 2019-06-26 | 1.16 | Cyclophilin A single mutant D66A in complex with an inhibitor. |
| 5JG1 | 2016-09-21 | 1.16 | HIV-1 wild Type protease with GRL-031-14A (a Adamantane P1-Ligand with tetrahydropyrano-tetrahydrofuran in P2 and isobutylamine in P1') |
| 6GJL | 2018-11-07 | 1.16 | Cyclophilin A complexed with tri-vector ligand 10. |
| 3I6O | 2009-09-29 | 1.17 | Crystal structure of wild type HIV-1 protease with macrocyclic inhibitor GRL-0216A |
| 6VCE | 2020-07-01 | 1.18 | HIV-1 wild type protease with GRL-026-18A, a crown-like tetrahydropyranotetrahydrofuran with a bridged methylene group as a P2 ligand |
| 4MC9 | 2014-04-02 | 1.19 | HIV protease in complex with AA74 |
| 2X25 | 2010-03-23 | 1.2 | Free acetyl-CypA orthorhombic form |
| 3DS2 | 2008-09-02 | 1.2 | HIV-1 capsid C-terminal domain mutant (Y169A) |
| 6DV0 | 2018-10-31 | 1.2 | HIV-1 wild type protease with GRL-02815A, a thiochroman heterocycle with (S)-Boc-amine functionality as the P2 ligand |
| 2J9K | 2007-08-28 | 1.2 | Atomic-resolution Crystal Structure of Chemically-Synthesized HIV-1 Protease Complexed with Inhibitor MVT-101 |
| 4YUO | 2015-05-20 | 1.2 | High-resolution multiconformer synchrotron model of CypA at 273 K |
| 1T3R | 2005-05-03 | 1.2 | HIV protease wild-type in complex with TMC114 inhibitor |
| 1K1T | 2002-07-10 | 1.2 | Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance |
| 5AGZ | 2015-05-06 | 1.2 | Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II) |
| 2QCI | 2008-04-22 | 1.2 | HIV-1 Protease mutant D30N with potent Antiviral inhibitor GRL-98065 |
| 3NU4 | 2010-08-25 | 1.2 | Crystal Structure of HIV-1 Protease Mutant V32I with Antiviral Drug Amprenavir |
| 6DIF | 2018-10-17 | 1.2 | Wild-type HIV-1 protease in complex with tipranavir |
| 2R8N | 2008-07-29 | 1.2 | Structural Analysis of the Unbound Form of HIV-1 Subtype C Protease |
| 3CYX | 2008-05-27 | 1.2 | Crystal structure of HIV-1 mutant I50V and inhibitor saquinavira |
| 4FL8 | 2012-10-17 | 1.2 | HIV-1 protease complexed with gem-diol-amine tetrahedral intermediate |
| 6PRF | 2019-09-18 | 1.21 | HIV-1 Protease multiple drug resistant clinical isolate mutant PR20 with GRL-14213A |
| 4HDP | 2013-08-14 | 1.22 | Crystal Structure of HIV-1 protease mutants I50V complexed with inhibitor GRL-0519 |
| 6E9A | 2018-11-07 | 1.22 | HIV-1 WILD TYPE PROTEASE WITH GRL-034-17A, (3aS, 5R, 6aR)-2-OXOHEXAHYD CYCLOPENTA[D]-5-OXAZOLYL URETHANE WITH A BICYCLIC OXAZOLIDINONE SCAFF AS THE P2 LIGAND |
| 5DGU | 2015-10-28 | 1.22 | Crystal Structure of HIV-1 Protease Inhibitors Containing Substituted fused-Tetrahydropyranyl Tetrahydrofuran as P2-Ligand GRL-004-11A |
| 2F8G | 2006-03-07 | 1.22 | HIV-1 protease mutant I50V complexed with inhibitor TMC114 |
| 4DFG | 2012-03-21 | 1.23 | Crystal Structure of Wild-type HIV-1 Protease with Cyclopentyltetrahydro- furanyl Urethanes as P2-ligand, GRL-0249A |
| 3TOG | 2012-08-15 | 1.24 | HIV-1 Protease - Epoxydic Inhibitor Complex (pH 9 - Monoclinic Crystal form P21) |
| 3NDU | 2011-07-20 | 1.25 | HIV-1 Protease Saquinavir:Ritonavir 1:5 complex structure |
| 5LUD | 2017-04-05 | 1.25 | Structure of Cyclophilin A in complex with 2,3-Diaminopyridine |
| 3VF5 | 2012-11-21 | 1.25 | Crystal Structure of HIV-1 Protease Mutant I47V with novel P1'-Ligands GRL-02031 |
| 6VOD | 2020-05-13 | 1.25 | HIV-1 wild type protease with GRL-052-16A, a tricyclic cyclohexane fused tetrahydrofuranofuran (CHf-THF) derivative as the P2 ligand |
| 1SDU | 2004-05-25 | 1.25 | Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site. |
| 2F81 | 2006-03-07 | 1.25 | HIV-1 Protease mutant L90M complexed with inhibitor TMC114 |
| 3K0M | 2009-12-08 | 1.25 | Cryogenic structure of CypA |
| 6DJ1 | 2018-10-17 | 1.26 | Wild-type HIV-1 protease in complex with Lopinavir |
| 5AH8 | 2015-05-06 | 1.26 | Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II) |
| 5UPZ | 2017-05-10 | 1.27 | HIV-1 wild Type protease with GRL-0518A , an isophthalamide-derived P2-P3 ligand with the para-hydoxymethyl sulfonamide isostere as the P2' group |
| 3OK9 | 2010-09-22 | 1.27 | Crystal structure of wild-type HIV-1 protease with new oxatricyclic designed inhibitor GRL-0519A |
| 2QD6 | 2008-04-22 | 1.28 | HIV-1 Protease Mutant I50V with potent Antiviral inhibitor GRL-98065 |
| 3NU5 | 2010-08-25 | 1.29 | Crystal Structure of HIV-1 Protease Mutant I50V with Antiviral Drug Amprenavir |
| 3H5B | 2009-06-16 | 1.29 | Crystal structure of wild type HIV-1 protease with novel P1'-ligand GRL-02031 |
| 4HDF | 2013-08-14 | 1.29 | Crystal Structure of HIV-1 protease mutants V82A complexed with inhibitor GRL-0519 |
| 6GJY | 2018-11-07 | 1.29 | Cyclophilin A complexed with tri-vector ligand 5. |
| 5BS4 | 2015-09-09 | 1.29 | HIV-1 wild Type protease with GRL-047-11A (a methylamine bis-Tetrahydrofuran P2-Ligand, 4-amino sulfonamide derivative) |
| 2AOC | 2006-01-17 | 1.3 | Crystal structure analysis of HIV-1 protease mutant I84V with a substrate analog P2-NC |
| 3HAU | 2011-04-27 | 1.3 | Crystal structure of chemically synthesized HIV-1 protease with reduced isostere MVT-101 inhibitor |
| 6E7J | 2018-11-07 | 1.3 | HIV-1 wild type protease with GRL-042-17A, 3-phenylhexahydro-2h-cyclopenta[d]oxazol-2-one with a bicyclic oxazolidinone scaffold as the P2 ligand |
| 3KFR | 2010-02-23 | 1.3 | HIV Protease (PR) dimer with inhibitor TL-3 bound and fragment 1F1 in the outside/top of flap |
| 5NOU | 2017-07-12 | 1.3 | Structure of cyclophilin A in complex with hexahydropyrimidin-2-one |
| 1SDT | 2004-05-25 | 1.3 | Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site. |
| 6VOE | 2020-05-13 | 1.3 | HIV-1 wild type protease with GRL-019-17A, a tricyclic cyclohexane fused tetrahydrofuranofuran (CHf-THF) derivative as the P2 ligand and a aminobenzothiazole(Abt)-based P2'-ligand |
| 2IEN | 2006-10-03 | 1.3 | Crystal structure analysis of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) |
| 4DQE | 2012-03-07 | 1.3 | Crystal Structure of (G16C/L38C) HIV-1 Protease in Complex with DRV |
| 3BVB | 2008-04-01 | 1.3 | Cystal structure of HIV-1 Active Site Mutant D25N and inhibitor Darunavir |
| 3HAW | 2011-04-27 | 1.3 | Crystal structure of [L-Ala51/51']HIV-1 protease with reduced isostere MVT-101 inhibitor |
| 3VF7 | 2012-11-21 | 1.3 | Crystal Structure of HIV-1 Protease Mutant L76V with novel P1'-Ligands GRL-02031 |
| 3D1Z | 2008-05-27 | 1.3 | Crystal structure of HIV-1 mutant I54M and inhibitor DARUNAVIR |
| 2A1E | 2006-02-21 | 1.3 | High resolution structure of HIV-1 PR with TS-126 |
| 2AVQ | 2006-01-24 | 1.3 | Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S |
| 4YHQ | 2015-06-10 | 1.3 | Crystal structure of multidrug resistant clinical isolate PR20 with GRL-5010A |
| 4U8W | 2014-11-05 | 1.3 | HIV-1 wild Type protease with GRL-050-10A (a Gem-difluoro-bis-Tetrahydrofuran as P2-Ligand) |
| 6FK1 | 2019-02-06 | 1.3 | Cyclophilin A |
| 4FLG | 2012-10-17 | 1.31 | HIV-1 protease mutant I47V complexed with reaction intermediate |
| 4MC6 | 2014-04-02 | 1.31 | HIV protease in complex with SA499 |
| 4J55 | 2013-05-15 | 1.31 | Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical isolate PR20 with the potent antiviral inhibitor GRL-02031 |
| 6DJ7 | 2018-10-17 | 1.31 | HIV-1 protease with mutation L76V in complex with GRL-5010 (gem-difluoro-bis-tetrahydrofuran as P2 ligand) |
| 3TL9 | 2012-04-25 | 1.32 | crystal structure of HIV protease model precursor/Saquinavir complex |
| 2AOF | 2006-01-17 | 1.32 | Crystal structure analysis of HIV-1 Protease mutant V82A with a substrate analog P1-P6 |
| 2O4L | 2006-12-12 | 1.33 | Crystal Structure of HIV-1 Protease (Q7K, I50V) in Complex with Tipranavir |
| 5UOV | 2017-05-10 | 1.33 | HIV-1 wild Type protease with GRL-1118A , an isophthalamide-derived P2-P3 ligand with the sulfonamide isostere as the P2' group |
| 3TH9 | 2011-09-28 | 1.34 | Crystal Structure of HIV-1 Protease Mutant Q7K V32I L63I with a cyclic sulfonamide inhibitor |
| 5BRY | 2015-09-09 | 1.34 | HIV-1 wild Type protease with GRL-011-11A (a methylamine bis-Tetrahydrofuran P2-Ligand, sulfonamide isostere derivate) |
| 4YUH | 2015-10-14 | 1.34 | Multiconformer synchrotron model of CypA at 150 K |
| 6GJM | 2018-11-07 | 1.35 | Cyclophilin A complexed with tri-vector ligand 4. |
| 3NUO | 2010-08-25 | 1.35 | Crystal Structure of HIV-1 Protease Mutant L90M with Antiviral Drug Amprenavir |
| 1T7I | 2005-05-10 | 1.35 | The structural and thermodynamic basis for the binding of TMC114, a next-generation HIV-1 protease inhibitor. |
| 2BB9 | 2005-11-15 | 1.35 | Structure of HIV1 protease and AKC4p_133a complex. |
| 4YE3 | 2015-06-10 | 1.35 | Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 with Inhibitor GRL-4410A |
| 5AHA | 2015-05-06 | 1.35 | Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II) |
| 2QD8 | 2008-04-22 | 1.35 | HIV-1 Protease Mutant I84V with potent Antiviral inhibitor GRL-98065 |
| 5NOS | 2017-07-12 | 1.35 | Structure of cyclophilin A in complex with 3-amino-1H-pyridin-2-one |
| 3TKG | 2012-04-25 | 1.36 | crystal structure of HIV model protease precursor/saquinavir complex |
| 6DJ2 | 2018-10-17 | 1.36 | HIV-1 protease with single mutation L76V in complex with Lopinavir |
| 3QN8 | 2012-02-08 | 1.38 | HIV-1 protease (mutant Q7K L33I L63I) in complex with a novel inhibitor |
| 4U1J | 2015-04-08 | 1.38 | HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential HIV-1 escape through identical epitopes |
| 6I42 | 2020-02-19 | 1.38 | Structure of the alpha-Synuclein PreNAC/Cyclophilin A-complex |
| 6GJJ | 2018-11-07 | 1.38 | Cyclophilin A complexed with tri-vector ligand 2. |
| 3UCB | 2012-03-28 | 1.38 | Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Darunavir |
| 4U7V | 2015-03-25 | 1.38 | Structure of wild-type HIV protease in complex with degraded photosensitive inhibitor |
| 4YUI | 2015-10-14 | 1.38 | Multiconformer synchrotron model of CypA at 180 K |
| 4MC1 | 2014-04-02 | 1.39 | HIV protease in complex with SA526P |
| 3K4V | 2010-06-09 | 1.39 | New crystal form of HIV-1 Protease/Saquinavir structure reveals carbamylation of N-terminal proline |
| 3K0N | 2009-12-08 | 1.39 | Room temperature structure of CypA |
| 3QIH | 2012-02-01 | 1.39 | HIV-1 protease (mutant Q7K L33I L63I) in complex with a novel inhibitor |
| 3QAA | 2011-12-21 | 1.4 | HIV-1 wild type protease with a substituted bis-Tetrahydrofuran inhibitor, GRL-044-10A |
| 3QIO | 2011-04-20 | 1.4 | Crystal Structure of HIV-1 RNase H with engineered E. coli loop and N-hydroxy quinazolinedione inhibitor |
| 4DGD | 2012-02-08 | 1.4 | TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant |
| 5T9Z | 2017-01-25 | 1.4 | Discovery of a Potent Cyclophilin Inhibitor (Compound 6) based on Structural Simplification of Sanglifehrin A |
| 6X3Y | 2020-06-24 | 1.4 | Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors |
| 2AOI | 2006-01-17 | 1.4 | Crystal structure analysis of HIV-1 protease with a substrate analog P1-P6 |
| 2XDE | 2010-12-22 | 1.4 | Crystal structure of the complex of PF-3450074 with an engineered HIV capsid N terminal domain |
| 3KA2 | 2011-04-27 | 1.4 | Crystal structure of chemically synthesized 203 amino acid 'covalent dimer' [L-Ala;Gly51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.4 A resolution |
| 1SDV | 2004-05-25 | 1.4 | Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site. |
| 3CYW | 2008-05-27 | 1.4 | Effect of Flap Mutations on Structure of HIV-1 Protease and Inhibition by Saquinavir and Darunavir |
| 2X2A | 2010-03-23 | 1.4 | Free acetyl-CypA trigonal form |
| 2AOD | 2006-01-17 | 1.4 | Crystal structure analysis of HIV-1 protease with a substrate analog P2-NC |
| 4FM6 | 2012-10-17 | 1.4 | HIV-1 protease mutant V32I complexed with reaction intermediate |
| 2QNP | 2008-04-15 | 1.41 | HIV-1 Protease in complex with a iodo decorated pyrrolidine-based inhibitor |
| 4YUJ | 2015-10-14 | 1.42 | Multiconformer synchrotron model of CypA at 240 K |
| 4YUL | 2015-10-14 | 1.42 | Multiconformer synchrotron model of CypA at 280 K |
| 2AOH | 2006-01-17 | 1.42 | Crystal structure analysis of HIV-1 Protease mutant V82A with a substrate analog P6-PR |
| 5WC7 | 2018-04-18 | 1.43 | CypA Mutant - I97V S99T C115S |
| 5NOY | 2017-07-12 | 1.43 | Structure of cyclophilin A in complex with 3,4-diaminobenzamide |
| 3VFA | 2012-11-21 | 1.43 | Crystal Structure of HIV-1 Protease Mutant V82A with novel P1'-Ligands GRL-02031 |
| 5AH9 | 2015-05-06 | 1.44 | Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II) |
| 2FNT | 2006-09-05 | 1.44 | Crystal structure of a drug-resistant (V82A) inactive (D25N) HIV-1 protease complexed with AP2V variant of HIV-1 NC-p1 substrate. |
| 3PWR | 2011-04-20 | 1.45 | HIV-1 Protease Mutant L76V complexed with Saquinavir |
| 3O9I | 2011-08-10 | 1.45 | Crystal Structure of wild-type HIV-1 Protease in complex with af61 |
| 3TOF | 2012-08-15 | 1.45 | HIV-1 Protease - Epoxydic Inhibitor Complex (pH 6 - Orthorombic Crystal form P212121) |
| 3QP0 | 2012-02-15 | 1.45 | HIV-1 protease (mutant Q7K L33I L63I) in complex with a novel inhibitor |
| 2F80 | 2006-03-07 | 1.45 | HIV-1 Protease mutant D30N complexed with inhibitor TMC114 |
| 3ST5 | 2011-08-17 | 1.45 | Crystal structure of wild-type HIV-1 protease with C3-Substituted Hexahydrocyclopentafuranyl Urethane as P2-Ligand, GRL-0489A |
| 5NOT | 2017-07-12 | 1.45 | Structure of cyclophilin A in complex with 4-chloropyrimidin-5-amine |
| 3QBF | 2012-01-18 | 1.45 | HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor |
| 3NYG | 2011-11-02 | 1.45 | X-ray structure of ester chemical analogue [O-Gly51,O-Gly51']HIV-1 protease complexed with MVT-101 inhibitor |
| 3WNF | 2013-12-25 | 1.45 | Cyclic hexapeptide CKIDNC in complex with HIV-1 integrase |
| 3UFN | 2012-03-28 | 1.45 | Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Saquinavir |
| 3PWM | 2011-04-20 | 1.46 | HIV-1 Protease Mutant L76V with Darunavir |
| 6OYD | 2020-05-20 | 1.46 | X-ray crystal structure of wild type HIV-1 protease in complex with GRL-004 |
| 4HEG | 2013-08-21 | 1.46 | Crystal Structure of HIV-1 protease mutants R8Q complexed with inhibitor GRL-0519 |
| 6O48 | 2019-06-19 | 1.46 | Wild-type HIV-1 protease in complex with a substrate analog CA-p2 |
| 3B7V | 2007-12-18 | 1.46 | HIV-1 protease complexed with gem-diol-amine tetrahedral intermediate NLLTQI |
| 6B3F | 2018-01-03 | 1.46 | Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,5S)-5-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide |
| 4N1S | 2015-08-12 | 1.47 | Structure of Cyclophilin A in complex with benzohydrazide. |
| 6MCR | 2019-04-24 | 1.48 | X-ray crystal structure of wild type HIV-1 protease in complex with GRL-001 |
| 4YUK | 2015-10-14 | 1.48 | Multiconformer synchrotron model of CypA at 260 K |
| 4YUG | 2015-10-14 | 1.48 | Multiconformer synchrotron model of CypA at 100 K |
| 2QNN | 2008-04-15 | 1.48 | HIV-1 protease in complex with a multiple decorated pyrrolidine-based inhibitor |
| 5TA2 | 2017-01-25 | 1.48 | Discovery of a Potent Cyclophilin Inhibitor (Compound 7) based on Structural Simplification of Sanglifehrin A |
| 6DIL | 2018-10-17 | 1.48 | HIV-1 protease with single mutation L76V in complex with tipranavir |
| 5NOW | 2017-07-12 | 1.48 | Structure of cyclophilin A in complex with pyridine-3,4-diamine |
| 6B38 | 2018-01-03 | 1.48 | Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,6R)-6-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide |
| 5JFP | 2016-09-21 | 1.49 | HIV-1 wild Type protease with GRL-097-13A (a Adamantane P1-Ligand with bis-THF in P2 and isobutylamine in P1') |
| 5NOX | 2017-07-12 | 1.49 | Structure of cyclophilin A in complex with 2-chloropyridin-3-amine |
| 4HDB | 2013-08-14 | 1.49 | Crystal Structure of HIV-1 protease mutants D30N complexed with inhibitor GRL-0519 |
| 2FGV | 2006-11-07 | 1.5 | X-ray crystal structure of HIV-1 Protease T80N variant in complex with the inhibitor saquinavir used to explore the role of invariant Thr80 in HIV-1 protease structure, function, and viral infectivity. |
| 6J1W | 2019-09-25 | 1.5 | The structure of HLA-A*3001/RT313 |
| 3WNH | 2013-12-25 | 1.5 | Cyclic hexapeptide PKZDNv in complex with HIV-1 integrase |
| 4Q1Y | 2015-02-18 | 1.5 | Mutations Outside the Active Site of HIV-1 Protease Alter Enzyme Structure and Dynamic Ensemble of the Active Site to Confer Drug Resistance |
| 2AVV | 2006-01-24 | 1.5 | Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, and G73S |
| 6X4P | 2020-06-24 | 1.5 | Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: (2R,5S,11S,14S,18E)-2,11,17,17-tetramethyl-14-(propan-2-yl)-15-oxa-3,9,12,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone (compound 28) |
| 5HSV | 2017-08-16 | 1.5 | X-Ray structure of a CypA-Alisporivir complex at 1.5 angstrom resolution |
| 5AHB | 2015-05-06 | 1.5 | Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II) |
| 5YOJ | 2018-07-11 | 1.5 | Structure of A17 HIV-1 Protease in Complex with Inhibitor KNI-1657 |
| 4YUM | 2015-10-14 | 1.5 | Multiconformer synchrotron model of CypA at 300 K |
| 2PWR | 2008-04-15 | 1.5 | HIV-1 protease in complex with a carbamoyl decorated pyrrolidine-based inhibitor |
| 3NUJ | 2010-08-25 | 1.5 | Crystal Structure of HIV-1 Protease Mutant I54V with Antiviral Drug Amprenavir |
| 4NX4 | 2014-02-26 | 1.5 | Re-refinement of CAP-1 HIV-CA complex |
| 3B80 | 2007-12-18 | 1.5 | HIV-1 protease mutant I54V complexed with gem-diol-amine intermediate NLLTQI |
| 5AH6 | 2015-05-06 | 1.5 | Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II) |
| 4DQB | 2012-03-07 | 1.5 | Crystal Structure of wild-type HIV-1 Protease in Complex with DRV |
| 5AHC | 2015-05-06 | 1.5 | Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II) |
| 4QJ6 | 2014-10-29 | 1.5 | Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with p1-p6 substrate variant (L449F) |
| 2WLW | 2009-09-22 | 1.5 | Structure of the N-terminal capsid domain of HIV-2 |
| 6X4O | 2020-06-24 | 1.5 | Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: (2R,5S,11S,14S,18E)-2,11-dimethyl-14-(propan-2-yl)-3-oxa-9,12,15,21,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(26),18,20,22,24,27-hexaene-4,10,13,16-tetrone (compound 21) |
| 5TA4 | 2017-01-25 | 1.5 | Discovery of a Potent Cyclophilin Inhibitor (Compound 8) based on Structural Simplification of Sanglifehrin A |
| 6X4M | 2020-06-24 | 1.5 | Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: tert-butyl [(2S)-1-{[(3S,17S)-2,16-dioxo-10,15-dioxa-1,21-diazatricyclo[15.3.1.1~5,9~]docosa-5(22),6,8-trien-3-yl]amino}-3-methyl-1-oxobutan-2-yl]carbamate (compound 3) |
| 6B3G | 2018-01-03 | 1.5 | Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,6S)-6-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide |
| 3NWQ | 2011-11-02 | 1.5 | X-ray structure of ester chemical analogue [O-Ile50,O-Ile50']HIV-1 protease complexed with MVT-101 |
| 1XL2 | 2005-06-07 | 1.5 | HIV-1 Protease in complex with pyrrolidinmethanamine |
| 6BTA | 2018-04-18 | 1.5 | CypA Mutant - S99T C115S |
| 4A6C | 2012-05-09 | 1.5 | Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based HIV-1 Protease Inhibitors |
| 4N1N | 2015-08-12 | 1.5 | Structure of Cyclophilin A in complex with Benzamide. |
| 6X4N | 2020-06-24 | 1.51 | Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: (2R,5S,11S,14S,18E)-2,11,17,17-tetramethyl-14-(propan-2-yl)-3-oxa-9,12,15,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone (compound 24) |
| 4G1Q | 2013-02-06 | 1.51 | Crystal structure of HIV-1 reverse transcriptase (RT) in complex with Rilpivirine (TMC278, Edurant), a non-nucleoside rt-inhibiting drug |
| 6MCS | 2019-04-24 | 1.52 | X-ray crystal structure of wild type HIV-1 protease in complex with GRL-003 |
| 6PYL | 2019-11-27 | 1.52 | Crystal Structure of HLA-B*2703 in complex with KK10, an HIV peptide |
| 5ULT | 2017-05-03 | 1.53 | HIV-1 wild Type protease with GRL-100-13A (a Crown-like Oxotricyclic Core as the P2-Ligand with the sulfonamide isostere as the P2' group) |
| 4ZLS | 2015-07-15 | 1.53 | HIV-1 wild Type protease with GRL-096-13A (a Boc-derivative P2-Ligand, 3,-5-dimethylbiphenyl P1-Ligand) |
| 4E43 | 2012-05-30 | 1.54 | HIV protease (PR) dimer with acetate in exo site and peptide in active site |
| 2AOE | 2006-01-17 | 1.54 | crystal structure analysis of HIV-1 protease mutant V82A with a substrate analog CA-P2 |
| 4QJA | 2014-10-29 | 1.54 | Crystal structure of inactive HIV-1 protease in complex with p1-p6 substrate variant (P453L) |
| 2O4S | 2006-12-12 | 1.54 | Crystal Structure of HIV-1 Protease (Q7K) in Complex with Lopinavir |
| 6OYR | 2020-05-20 | 1.54 | X-ray crystal structure of wild type HIV-1 protease in complex with GRL-002 |
| 3ZPT | 2013-11-06 | 1.54 | Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors |
| 1K1U | 2002-07-10 | 1.55 | Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance |
| 5AH7 | 2015-02-18 | 1.55 | Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II) |
| 4CPS | 2014-12-17 | 1.55 | Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol |
| 3K0O | 2009-12-08 | 1.55 | Room temperature structure of CypA mutant Ser99Thr |
| 2PQZ | 2008-04-15 | 1.55 | HIV-1 Protease in complex with a pyrrolidine-based inhibitor |
| 3VFB | 2012-11-21 | 1.55 | Crystal Structure of HIV-1 Protease Mutant N88D with novel P1'-Ligands GRL-02031 |
| 3ZPS | 2013-11-06 | 1.55 | Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors |
| 3TKW | 2012-04-25 | 1.55 | Crystal structure of HIV protease model precursor/Darunavir complex |
| 1DAZ | 2000-05-03 | 1.55 | Structural and kinetic analysis of drug resistant mutants of HIV-1 protease |
| 5NMH | 2017-11-15 | 1.55 | HLA A02 presenting SLYNTIATL |
| 4J54 | 2013-05-15 | 1.55 | Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical isolate PR20 with the potent antiviral inhibitor GRL-0519A |
| 4MC2 | 2014-04-02 | 1.56 | HIV protease in complex with SA525P |
| 6U5E | 2020-01-29 | 1.56 | RT XFEL structure of CypA solved using celloluse carrier media |
| 4YUN | 2015-10-14 | 1.58 | Multiconformer synchrotron model of CypA at 310 K |
| 1AWQ | 1998-03-18 | 1.58 | CYPA COMPLEXED WITH HAGPIA (PSEUDO-SYMMETRIC MONOMER) |
| 1AWR | 1998-03-18 | 1.58 | CYPA COMPLEXED WITH HAGPIA |
| 2R43 | 2008-09-09 | 1.58 | I50V HIV-1 protease in complex with an amino decorated pyrrolidine-based inhibitor |
| 4U1H | 2015-04-08 | 1.59 | HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential HIV-1 escape through identical epitopes |
| 3QRS | 2012-02-22 | 1.59 | HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor |
| 4COC | 2014-06-04 | 1.59 | HIV-1 capsid C-terminal domain mutant (Y169L) |
| 1EXQ | 2000-11-03 | 1.6 | CRYSTAL STRUCTURE OF THE HIV-1 INTEGRASE CATALYTIC CORE DOMAIN |
| 3BXS | 2008-03-25 | 1.6 | Crystal Structures Of Highly Constrained Substrate And Hydrolysis Products Bound To HIV-1 Protease. Implications For Catalytic Mechanism |
| 2Z4O | 2008-04-22 | 1.6 | Wild Type HIV-1 Protease with potent Antiviral inhibitor GRL-98065 |
| 6GJI | 2018-11-07 | 1.6 | Cyclophilin A complexed with the tri-vector ligand 8. |
| 3EKW | 2009-09-01 | 1.6 | Crystal structure of the inhibitor Atazanavir (ATV) in complex with a multi-drug resistance HIV-1 protease variant (L10I/G48V/I54V/V64I/V82A) Refer: FLAP+ in citation. |
| 3HLO | 2011-07-27 | 1.6 | Crystal structure of chemically synthesized 'covalent dimer' [Gly51/D-Ala51']HIV-1 protease |
| 2AOJ | 2006-01-17 | 1.6 | Crystal structure analysis of HIV-1 protease with a substrate analog P6-PR |
| 5NOQ | 2017-07-12 | 1.6 | Structure of cyclophilin A in complex with 3-chloropyridin-2-amine |
| 1YND | 2005-04-05 | 1.6 | Structure of human cyclophilin A in complex with the novel immunosuppressant sanglifehrin A at 1.6A resolution |
| 3DS1 | 2008-09-02 | 1.6 | HIV-1 capsid C-terminal domain mutant (E187A) in complex with an inhibitor of particle assembly (CAI) |
| 3OUB | 2011-03-30 | 1.6 | MDR769 HIV-1 protease complexed with NC/p1 hepta-peptide |
| 3BXR | 2008-03-25 | 1.6 | Crystal Structures Of Highly Constrained Substrate And Hydrolysis Products Bound To HIV-1 Protease. Implications For Catalytic Mechanism |
| 2O4K | 2006-12-12 | 1.6 | Crystal Structure of HIV-1 Protease (Q7K) in Complex with Atazanavir |
| 3FSM | 2010-01-05 | 1.6 | CRYSTAL STRUCTURE OF A CHEMICALLY SYNTHESIZED 203 AMINO ACID 'COVALENT DIMER' [L-Ala51,D-Ala51'] HIV-1 PROTEASE MOLECULE |
| 6B3C | 2018-01-03 | 1.6 | Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,6R)-6-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide |
| 3EL9 | 2009-09-01 | 1.6 | Crystal structure of atazanavir (ATV) in complex with a multidrug HIV-1 protease (V82T/I84V) |
| 3EL5 | 2009-09-01 | 1.6 | Crystal structure of nelfinavir (NFV) complexed with a multidrug variant (ACT) (V82T/I84V) of HIV-1 protease |
| 3JVY | 2009-12-08 | 1.6 | HIV-1 Protease Mutant G86A with DARUNAVIR |
| 4G9D | 2013-03-20 | 1.6 | Crystal Structure of HLA B2705-KK10 |
| 3DS0 | 2008-09-02 | 1.6 | HIV-1 capsid C-terminal domain mutant (N183A) in complex with an inhibitor of particle assembly (CAI) |
| 3OU4 | 2011-03-30 | 1.6 | MDR769 HIV-1 protease complexed with TF/PR hepta-peptide |
| 4G8I | 2013-03-20 | 1.6 | Crystal Structure of HLA B2705-KK10-L6M |
| 3QPJ | 2012-02-15 | 1.61 | HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor |
| 3IAW | 2011-04-27 | 1.61 | Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution |
| 5NOZ | 2017-07-12 | 1.61 | Structure of cyclophilin A in complex with 3,4-diaminobenzohydrazide |
| 6C8X | 2018-12-05 | 1.61 | Wild-type HIV-1 protease in complex with a phenylboronic acid (P2') analog of darunavir |
| 6B3H | 2018-01-03 | 1.62 | Crystal Structure of HIV Protease complexed with N-(2-(2-((6R,9S)-2,2-dioxido-2-thia-1,7-diazabicyclo[4.3.1]decan-9-yl)ethyl)-3-fluorophenyl)-3,3-bis(4-fluorophenyl)propanamide |
| 5DGW | 2015-10-28 | 1.62 | Crystal Structure of HIV-1 Protease Inhibitor GRL-105-11A Containing Substituted fused-Tetrahydropyranyl Tetrahydrofuran as P2-Ligand |
| 6U5C | 2020-01-29 | 1.62 | RT XFEL structure of CypA solved using MESH injection system |
| 3QRO | 2012-02-22 | 1.62 | HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor |
| 2CPL | 1993-10-31 | 1.63 | SIMILARITIES AND DIFFERENCES BETWEEN HUMAN CYCLOPHILIN A AND OTHER BETA-BARREL STRUCTURES. STRUCTURAL REFINEMENT AT 1.63 ANGSTROMS RESOLUTION |
| 6B36 | 2018-01-03 | 1.63 | Crystal Structure of HIV Protease complexed with (S)-N-(3-fluoro-2-(2-(1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide |
| 3UF3 | 2012-03-28 | 1.63 | Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical isolate PR20 |
| 2CYH | 1996-07-11 | 1.64 | CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE ALA-PRO |
| 4IPY | 2013-10-16 | 1.64 | HIV capsid C-terminal domain |
| 3K0P | 2009-12-08 | 1.65 | Cryogenic structure of CypA mutant Ser99Thr |
| 5KRT | 2016-09-28 | 1.65 | HIV-1 Integrase Catalytic Core Domain (CCD) in Complex with a Fragment-Derived Allosteric Inhibitor |
| 3CKT | 2009-03-24 | 1.65 | HIV-1 protease in complex with a dimethylallyl decorated pyrrolidine based inhibitor (orthorombic space group) |
| 3OXX | 2011-09-28 | 1.65 | Crystal Structure of HIV-1 I50V, A71V Protease in Complex with the Protease Inhibitor Atazanavir |
| 3O9G | 2011-08-10 | 1.65 | Crystal Structure of wild-type HIV-1 Protease in complex with af53 |
| 2ZGA | 2009-02-03 | 1.65 | HIV-1 protease in complex with a dimethylallyl decorated pyrrolidine based inhibitor (hexagonal space group) |
| 4OBK | 2014-11-26 | 1.65 | Crystal structure of inactive HIV-1 protease in complex with the P1-P6 substrate variant (L449F/S451N) |
| 2XXM | 2011-10-12 | 1.65 | Crystal structure of the HIV-1 capsid protein C-terminal domain in complex with a camelid VHH and the CAI peptide. |
| 6U5D | 2020-01-29 | 1.65 | RT XFEL structure of CypA solved using LCP injection system |
| 2NPH | 2006-12-19 | 1.65 | Crystal structure of HIV1 protease in situ product complex |
| 4CF8 | 2013-12-11 | 1.65 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 1ZPK | 2006-04-25 | 1.65 | Crystal structure of the complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2 |
| 3KT2 | 2010-02-16 | 1.65 | Crystal Structure of N88D mutant HIV-1 Protease |
| 5UFZ | 2018-01-10 | 1.65 | HIV-1 Protease complexed with Inhibitor: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2S)-1-(1-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}cyclopropyl)-1-hydroxy-3-phenylpropan-2-yl]carbamate |
| 1W8M | 2004-09-30 | 1.65 | Enzymatic and Structural Characterisation of Non Peptide Ligand Cyclophilin Complexes |
| 4N1Q | 2015-08-12 | 1.65 | Structure of Cyclophilin A in complex with cyclohexanecarboxamide. |
| 6P9A | 2020-04-15 | 1.66 | HIV-1 Protease multiple mutant PRS5B with Darunavir |
| 3KDB | 2010-03-02 | 1.66 | Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10006 |
| 5NMK | 2017-11-15 | 1.66 | HLA A02 presenting SLFNTIAVL |
| 6BZ2 | 2018-02-28 | 1.67 | Crystal structure of wild-type HIV-1 protease with a novel HIV-1 inhibitor GRL-14213A of 6-5-5-ring fused crown-like tetrahydropyranofuran as the P2-ligand, a cyclopropylaminobenzothiazole as the P2'-ligand and 3,5-difluorophenylmethyl as the P1-ligand |
| 4IPZ | 2013-11-06 | 1.67 | SmBz bound to Cyclophilin A |
| 4QJ7 | 2014-10-29 | 1.67 | Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with p1-p6 substrate variant (R452S) |
| 4OBF | 2014-11-26 | 1.68 | Crystal Structure of Nelfinavir-Resistant, Inactive HIV-1 Protease Variant (D30N/N88D) in Complex with the p1-p6 substrate variant (S451N) |
| 6GJR | 2018-11-07 | 1.69 | Cyclophilin A complexed with tri-vector ligand 9. |
| 2WHH | 2009-12-01 | 1.69 | HIV-1 protease tethered dimer Q-product complex along with nucleophilic water molecule |
| 4EPJ | 2012-06-06 | 1.69 | Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate p2-NC |
| 3AVI | 2012-02-15 | 1.7 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
| 4F75 | 2013-05-15 | 1.7 | Crystal Structure of active HIV-1 Protease in Complex with the N terminal product of the substrate RH-IN |
| 3I8W | 2009-12-01 | 1.7 | Crystal structure of a metallacarborane inhibitor bound to HIV protease |
| 5KUV | 2016-08-10 | 1.7 | Human cyclophilin A at 100K, Data set 8 |
| 3EL1 | 2009-09-01 | 1.7 | Crystal Structure of wild-type HIV protease in complex with the inhibitor, Atazanavir |
| 3AVA | 2012-01-18 | 1.7 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
| 1W8V | 2004-09-30 | 1.7 | Enzymatic and structural characterization of non peptide ligand cyclophilin complexes |
| 5KUL | 2016-09-07 | 1.7 | Human cyclophilin A at 100K, Data set 1 |
| 3AVF | 2012-01-18 | 1.7 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
| 1M9X | 2003-05-27 | 1.7 | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,A88M,G89A Complex. |
| 3ZSR | 2012-07-11 | 1.7 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
| 4CHO | 2013-12-11 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 3OUA | 2011-03-30 | 1.7 | MDR769 HIV-1 protease complexed with p1/p6 hepta-peptide |
| 2BUO | 2005-07-21 | 1.7 | HIV-1 capsid C-terminal domain in complex with an inhibitor of particle assembly |
| 5KV0 | 2016-08-31 | 1.7 | Human cyclophilin A at 278K, Data set 2 |
| 3OU3 | 2011-03-30 | 1.7 | MDR769 HIV-1 protease complexed with PR/RT hepta-peptide |
| 1B9F | 1999-07-19 | 1.7 | MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY |
| 5XOS | 2017-06-14 | 1.7 | Crystal structure of HLA-B35 in complex with a pepetide antigen |
| 4CIE | 2014-01-08 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 4DGB | 2012-02-08 | 1.7 | TRIMCyp cyclophilin domain from Macaca mulatta: HIV-2 CA cyclophilin-binding loop complex |
| 1A8O | 1998-10-14 | 1.7 | HIV CAPSID C-TERMINAL DOMAIN |
| 3OTS | 2011-03-30 | 1.7 | MDR769 HIV-1 protease complexed with MA/CA hepta-peptide |
| 4CEQ | 2013-11-20 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 4E91 | 2012-04-25 | 1.7 | Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BD3 |
| 3ZT2 | 2012-07-11 | 1.7 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
| 2WKZ | 2009-12-15 | 1.7 | HIV-1 Protease Inhibitors Containing a Tertiary Alcohol in the Transition-State Mimic with Improved Cell-Based Antiviral Activity |
| 5KV3 | 2016-08-10 | 1.7 | Human cyclophilin A at 278K, Data set 5 |
| 5KUZ | 2016-08-10 | 1.7 | Human cyclophilin A at 278K, Data set 1 |
| 3AV9 | 2012-01-18 | 1.7 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
| 5KUS | 2016-08-10 | 1.7 | Human cyclophilin A at 100K, Data set 6 |
| 5JPA | 2016-08-10 | 1.7 | Hexameric HIV-1 CA H12Y mutant |
| 4CGF | 2013-12-04 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 4CER | 2013-11-20 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 4CHY | 2013-12-18 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 3O9H | 2011-08-10 | 1.7 | Crystal Structure of wild-type HIV-1 Protease in complex with kd26 |
| 3NLS | 2011-09-07 | 1.7 | Crystal Structure of HIV-1 Protease in Complex with KNI-10772 |
| 3IXO | 2010-03-02 | 1.7 | Crystal Structure of uncomplexed HIV_1 Protease Subtype A |
| 6GJN | 2018-11-07 | 1.7 | Cyclophilin A complexed with tri-vector ligand 15. |
| 4CJQ | 2014-01-08 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 5KV2 | 2016-08-10 | 1.7 | Human cyclophilin A at 278K, Data set 4 |
| 4CEZ | 2013-11-27 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 5KV6 | 2016-08-10 | 1.7 | Human cyclophilin A at 278K, Data set 8 |
| 5KV4 | 2016-08-10 | 1.7 | Human cyclophilin A at 278K, Data set 6 |
| 5KUN | 2016-08-10 | 1.7 | Human cyclophilin A at 100K, Data set 2 |
| 5JFU | 2016-09-21 | 1.7 | HIV-1 wild Type protease with GRL-007-14A (a Adamantane P1-Ligand with bis-THF in P2 and benzylamine in P1') |
| 3AVG | 2012-01-18 | 1.7 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
| 5KUU | 2016-08-31 | 1.7 | Human cyclophilin A at 100K, Data set 7 |
| 1K2B | 2002-07-10 | 1.7 | Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance |
| 2BBB | 2005-11-15 | 1.7 | Structure of HIV1 protease and hh1_173_3a complex. |
| 3ZSQ | 2012-07-11 | 1.7 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
| 4CPW | 2014-12-17 | 1.7 | Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol |
| 1FFI | 2001-06-01 | 1.7 | STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES |
| 3WNE | 2013-12-25 | 1.7 | Cyclic hexapeptide PKIDNG in complex with HIV-1 integrase |
| 4U7Q | 2015-03-25 | 1.7 | Structure of wild-type HIV protease in complex with photosensitive inhibitor PDI-6 |
| 4AH9 | 2012-12-19 | 1.7 | Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification |
| 4CPT | 2014-12-17 | 1.7 | Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol |
| 3QIN | 2011-04-20 | 1.7 | Crystal Structure of HIV-1 RNase H p15 with engineered E. coli loop and pyrimidinol carboxylic acid inhibitor |
| 4CIG | 2014-01-08 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 5KUR | 2016-09-07 | 1.7 | Human cyclophilin A at 100K, Data set 5 |
| 5KUO | 2016-08-31 | 1.7 | Human cyclophilin A at 100K, Data set 3 |
| 3I7E | 2009-09-29 | 1.7 | Co-crystal structure of HIV-1 protease bound to a mutant resistant inhibitor UIC-98038 |
| 1DIF | 1996-03-08 | 1.7 | HIV-1 PROTEASE IN COMPLEX WITH A DIFLUOROKETONE CONTAINING INHIBITOR A79285 |
| 4CJU | 2014-01-22 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 1B9D | 1999-07-19 | 1.7 | MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY |
| 1HYV | 2001-04-04 | 1.7 | HIV INTEGRASE CORE DOMAIN COMPLEXED WITH TETRAPHENYL ARSONIUM |
| 5KUQ | 2016-08-10 | 1.7 | Human cyclophilin A at 100K, Data set 4 |
| 5KRS | 2016-09-28 | 1.7 | HIV-1 Integrase Catalytic Core Domain in Complex with an Allosteric Inhibitor, 3-(1H-pyrrol-1-yl)-2-thiophenecarboxylic acid |
| 5KV5 | 2016-08-10 | 1.7 | Human cyclophilin A at 278K, Data set 7 |
| 4CJ3 | 2014-01-08 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 5KV1 | 2016-08-10 | 1.7 | Human cyclophilin A at 278K, Data set 3 |
| 3O9F | 2011-08-10 | 1.7 | Crystal Structure of wild-type HIV-1 Protease in complex with kd27 |
| 4OVL | 2014-03-05 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 5KUW | 2016-08-10 | 1.7 | Human cyclophilin A at 100K, Data set 9 |
| 4EQ0 | 2012-06-06 | 1.7 | Crystal Structure of inactive single chain variant of HIV-1 Protease in Complex with the substrate p2-NC |
| 4CEF | 2013-11-20 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 5KV7 | 2016-08-31 | 1.7 | Human cyclophilin A at 278K, Data set 9 |
| 3AVJ | 2012-01-18 | 1.7 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
| 3OQ7 | 2011-04-06 | 1.71 | Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants |
| 3HBO | 2010-05-26 | 1.71 | Crystal structure of chemically synthesized [D-Ala51/51']HIV-1 protease |
| 4QAG | 2014-06-04 | 1.71 | Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNASE H domain of HIV-1 reverse transcriptase |
| 4CJT | 2014-01-08 | 1.71 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 3OQD | 2011-04-06 | 1.71 | Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants |
| 1M9E | 2003-05-27 | 1.72 | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A Complex. |
| 3NDT | 2011-07-20 | 1.72 | HIV-1 Protease Saquinavir:Ritonavir 1:1 complex structure |
| 1M9F | 2003-05-27 | 1.73 | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,A88M Complex. |
| 3QRM | 2012-02-22 | 1.73 | HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor |
| 1XL5 | 2005-06-07 | 1.73 | HIV-1 Protease in complex with amidhyroxysulfone |
| 3BHE | 2008-12-09 | 1.75 | HIV-1 protease in complex with a three armed pyrrolidine derivative |
| 3WNG | 2013-12-25 | 1.75 | Cyclic hexapeptide PKIDNp in complex with HIV-1 integrase |
| 2UXZ | 2008-05-20 | 1.75 | Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary- Alcohol-Containing Transition-State Mimic |
| 3ZT1 | 2012-07-11 | 1.75 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
| 4CK1 | 2014-01-22 | 1.75 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 6DJ5 | 2018-10-17 | 1.75 | HIV-1 protease with mutation L76V in complex with GRL-0519 (tris-tetrahydrofuran as P2 ligand) |
| 4CJK | 2014-01-08 | 1.75 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 1D4L | 2000-10-11 | 1.75 | HIV-1 PROTEASE COMPLEXED WITH A MACROCYCLIC PEPTIDOMIMETIC INHIBITOR |
| 3ZSV | 2012-07-11 | 1.75 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
| 3AVK | 2012-01-18 | 1.75 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
| 4N1O | 2015-08-12 | 1.75 | Structure of Cyclophilin A in complex with Saccharin. |
| 3OTY | 2011-03-30 | 1.75 | MDR769 HIV-1 protease complexed with RT/RH hepta-peptide |
| 3ZSO | 2012-07-11 | 1.75 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based design |
| 6P9B | 2020-04-15 | 1.75 | HIV-1 Protease multiple drug resistant mutant PRS5B with Amprenavir |
| 4CEC | 2013-11-20 | 1.75 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 5HRN | 2016-12-14 | 1.75 | HIV Integrase Catalytic Domain containing F185K mutation complexed with GSK0002 |
| 4I8Z | 2013-07-24 | 1.75 | Crystal structure of wild type HIV-1 protease in complex with non-peptidic inhibitor, GRL008 |
| 4CED | 2013-11-20 | 1.75 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 3EKV | 2009-09-01 | 1.75 | Crystal structure of the wild type HIV-1 protease with the inhibitor, Amprenavir |
| 4OBJ | 2014-11-26 | 1.75 | Crystal Structure of Inactive HIV-1 Protease in Complex with the p1-p6 substrate variant (S451N) |
| 4CGG | 2013-12-04 | 1.75 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 1B6L | 2000-01-07 | 1.75 | HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 4 |
| 4AHS | 2012-12-19 | 1.75 | Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification |
| 4CEB | 2013-11-20 | 1.75 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 4YUP | 2015-10-14 | 1.75 | Multiconformer fixed-target X-ray free electron (XFEL) model of CypA at 273 K |
| 1MTR | 1996-08-01 | 1.75 | HIV-1 PROTEASE COMPLEXED WITH A CYCLIC PHE-ILE-VAL PEPTIDOMIMETIC INHIBITOR |
| 3OXV | 2011-09-28 | 1.75 | Crystal Structure of HIV-1 I50V, A71 Protease in Complex with the protease inhibitor amprenavir. |
| 3OY4 | 2011-02-09 | 1.76 | Crystal Structure of HIV-1 L76V Protease in Complex with the Protease Inhibitor Darunavir. |
| 5JL4 | 2017-10-04 | 1.76 | Inhibitor resistant mutant catalytic core domain of HIV-1 Integrase |
| 2UY0 | 2008-05-20 | 1.76 | Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary- Alcohol-Containing Transition-State Mimic |
| 4CGH | 2013-12-04 | 1.76 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 1MIK | 1996-03-08 | 1.76 | THE ROLE OF WATER MOLECULES IN THE STRUCTURE-BASED DESIGN OF (5-HYDROXYNORVALINE)-2-CYCLOSPORIN: SYNTHESIS, BIOLOGICAL ACTIVITY, AND CRYSTALLOGRAPHIC ANALYSIS WITH CYCLOPHILIN A |
| 5YRS | 2018-03-07 | 1.76 | X-ray Snapshot of HIV-1 Protease in Action: Observation of Tetrahedral Intermediate and Its SIHB with Catalytic Aspartate |
| 3LZU | 2010-08-11 | 1.76 | Crystal Structure of a Nelfinavir Resistant HIV-1 CRF01_AE Protease variant (N88S) in Complex with the Protease Inhibitor Darunavir. |
| 3KFP | 2010-02-23 | 1.77 | HIV Protease (PR) with inhibitor TL-3 bound, and DMSOs in exo site |
| 4CJL | 2014-01-08 | 1.77 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 3AVC | 2012-01-18 | 1.77 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
| 4U0C | 2014-11-12 | 1.77 | Hexameric HIV-1 CA in complex with Nup153 peptide, P6 crystal form |
| 3KFN | 2010-02-23 | 1.77 | HIV Protease (PR) with inhibitor TL-3 and fragment hit 4D9 by soaking |
| 1FEJ | 2001-06-01 | 1.78 | STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES |
| 4OBG | 2014-11-26 | 1.78 | Crystal Structure of Nelfinavir-Resistant, Inactive HIV-1 Protease (D30N/N88D) in Complex with the p1-p6 substrate. |
| 2PWC | 2008-04-15 | 1.78 | HIV-1 protease in complex with a amino decorated pyrrolidine-based inhibitor |
| 4DQH | 2012-03-07 | 1.79 | Crystal Structure of (R14C/E65C) HIV-1 Protease in complex with DRV |
| 4EJK | 2013-05-01 | 1.79 | HIV Protease (PR) dimer in closed form with pepstatin in active site and fragment 1F1-N in the outside/top of flap |
| 1EC0 | 2002-06-26 | 1.79 | HIV-1 protease in complex with the inhibitor bea403 |
| 4Q5M | 2015-04-08 | 1.79 | D30N tethered HIV-1 protease dimer/saquinavir complex |
| 4GB2 | 2013-07-31 | 1.79 | HIV-1 protease (mutant Q7K L33I L63I) in complex with a bicyclic pyrrolidine inhibitor |
| 4CK3 | 2014-01-22 | 1.79 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 1QBU | 1997-10-15 | 1.8 | HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY |
| 2XGY | 2010-09-22 | 1.8 | Complex of Rabbit Endogenous Lentivirus (RELIK)Capsid with Cyclophilin A |
| 4CJ4 | 2014-01-08 | 1.8 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 1PRO | 1996-08-17 | 1.8 | HIV-1 PROTEASE DIMER COMPLEXED WITH A-98881 |
| 2XYF | 2011-12-07 | 1.8 | HIV-1 Inhibitors with a Tertiary-Alcohol-containing Transition-State Mimic and various P2 and P1 prime Substituents |
| 3GI0 | 2011-08-10 | 1.8 | Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [l-ala51,d-ala51'] hiv-1 protease molecule complexed with jg-365 inhibitor |
| 3BGC | 2008-09-02 | 1.8 | HIV-1 protease in complex with a benzyl decorated oligoamine |
| 3NXN | 2011-11-02 | 1.8 | X-ray structure of ester chemical analogue 'covalent dimer' [Ile50,O-Ile50']HIV-1 protease complexed with KVS-1 inhibitor |
| 1W8L | 2004-09-30 | 1.8 | Enzymatic and structural characterization of non peptide ligand cyclophilin complexes |
| 4N1R | 2015-08-12 | 1.8 | Structure of Cyclophilin A in complex with benzenesulfonohydrazide. |
| 3KT5 | 2010-02-16 | 1.8 | Crystal Structure of N88S mutant HIV-1 Protease |
| 3NF7 | 2011-04-27 | 1.8 | Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design |
| 3OU1 | 2011-03-30 | 1.8 | MDR769 HIV-1 protease complexed with RH/IN hepta-peptide |
| 3KDD | 2010-03-02 | 1.8 | Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10265 |
| 2ZD1 | 2008-02-12 | 1.8 | Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with TMC278 (Rilpivirine), A Non-nucleoside RT Inhibitor |
| 4CPR | 2014-12-17 | 1.8 | Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol |
| 3OUD | 2011-03-30 | 1.8 | MDR769 HIV-1 protease complexed with CA/p2 hepta-peptide |
| 1FGL | 1997-04-01 | 1.8 | Cyclophilin A complexed with a fragment of HIV-1 GAG protein |
| 1CWL | 1998-07-15 | 1.8 | HUMAN CYCLOPHILIN A COMPLEXED WITH 4 4-HYDROXY-MELEU CYCLOSPORIN |
| 2QI4 | 2008-04-22 | 1.8 | Crystal structure of protease inhibitor, MIT-2-AD93 in complex with wild type HIV-1 protease |
| 3GGU | 2009-08-11 | 1.8 | HIV PR drug resistant patient's variant in complex with darunavir |
| 4ICL | 2013-02-06 | 1.8 | HIV-1 reverse transcriptase with bound fragment at the incoming dNTP binding site |
| 1BWB | 1998-09-30 | 1.8 | HIV-1 PROTEASE (V82F/I84V) DOUBLE MUTANT COMPLEXED WITH SD146 OF DUPONT PHARMACEUTICALS |
| 4CJR | 2014-01-08 | 1.8 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 1QBS | 1997-10-15 | 1.8 | HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY |
| 6AOC | 2018-08-08 | 1.8 | Crystal Structure of an N-Hydroxythienopyrimidine-2,4-dione RNase H Active Site Inhibitor with Multiple Binding Modes to HIV Reverse Transcriptase |
| 2R3T | 2008-09-02 | 1.8 | I50V HIV-1 protease mutant in complex with a carbamoyl decorated pyrrolidine-based inhibitor |
| 3GI5 | 2010-03-09 | 1.8 | Crystal structure of protease inhibitor, KB62 in complex with wild type HIV-1 protease |
| 2FXE | 2007-02-20 | 1.8 | X-ray crystal structure of HIV-1 protease CRM mutant complexed with atazanavir (BMS-232632) |
| 1HVK | 1994-04-30 | 1.8 | INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE |
| 4CEE | 2013-11-27 | 1.8 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 6X3R | 2020-06-24 | 1.8 | Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors |
| 3KFS | 2010-02-23 | 1.8 | HIV Protease (PR) dimer with inhibitor TL-3 bound and fragment 2F4 in the outside/top of flap |
| 4EQJ | 2012-06-06 | 1.8 | Crystal Structure of inactive single chain variant of HIV-1 Protease in Complex with the substrate RT-RH |
| 1W5W | 2004-12-22 | 1.8 | HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor |
| 1G35 | 2001-06-06 | 1.8 | CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR, AHA024 |
| 4AHT | 2012-12-19 | 1.8 | Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification |
| 4K4Q | 2013-09-18 | 1.8 | TL-3 inhibited Trp6Ala HIV Protease with 3-bromo-2,6-dimethoxybenzoic acid bound in flap site |
| 1HVL | 1994-04-30 | 1.8 | INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE |
| 1CWJ | 1998-08-26 | 1.8 | HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL 3-S-METHYL-SARCOSINE CYCLOSPORIN |
| 4A6B | 2012-05-09 | 1.8 | Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based HIV-1 Protease Inhibitors |
| 6X4Q | 2020-06-24 | 1.8 | Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: (2R,5S,11S,14S,18E)-14-cyclobutyl-2,11,17,17-tetramethyl-15-oxa-3,9,12,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone (compound 33) |
| 3ZSW | 2012-07-11 | 1.8 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
| 1CWK | 1998-07-15 | 1.8 | HUMAN CYCLOPHILIN A COMPLEXED WITH 1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORIN |
| 4J5J | 2013-05-15 | 1.8 | Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Amprenavir |
| 5NOR | 2017-07-12 | 1.8 | Structure of cyclophilin A in complex with 3-methylpyridin-2-amine |
| 4CHZ | 2013-12-18 | 1.8 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 3KF0 | 2010-02-23 | 1.8 | HIV Protease with fragment 4D9 bound |
| 4AHV | 2012-12-19 | 1.8 | Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification |
| 3JVW | 2009-12-08 | 1.8 | HIV-1 Protease Mutant G86A with symmetric inhibitor DMP323 |
| 1HVR | 1995-01-26 | 1.8 | RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS |
| 5VCK | 2018-04-18 | 1.8 | HIV Protease (PR) with TL-3 in the active site and (Z)-N-(thiazol-2-yl)-N'-tosylcarbamimidate in the exosite |
| 6PJG | 2020-07-01 | 1.8 | HIV-1 Protease NL4-3 WT in Complex with LR3-97 |
| 1FG6 | 2001-06-01 | 1.8 | STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES |
| 3AO2 | 2011-03-16 | 1.8 | Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase |
| 3EKY | 2009-09-01 | 1.8 | Crystal Structure of wild-type HIV protease in complex with the inhibitor, Atazanavir |
| 3HDK | 2010-04-28 | 1.8 | Crystal structure of chemically synthesized [Aib51/51']HIV-1 protease |
| 1HVH | 1998-12-30 | 1.8 | NONPEPTIDE CYCLIC CYANOGUANIDINES AS HIV PROTEASE INHIBITORS |
| 3ZPU | 2013-11-06 | 1.8 | Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors |
| 1HXW | 1998-02-04 | 1.8 | HIV-1 PROTEASE DIMER COMPLEXED WITH A-84538 |
| 3ZCM | 2012-12-05 | 1.8 | Small molecule inhibitors of the LEDGF site of HIV integrase identified by fragment screening and structure based design. |
| 4CJS | 2014-01-08 | 1.8 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 5KAO | 2016-08-31 | 1.8 | Crystal structure of wild type HIV-1 protease in complex with GRL-10413 |
| 4LH4 | 2013-12-25 | 1.8 | Dual inhibition of HIV-1 replication by Integrase-LEDGF allosteric inhibitors is predominant at post-integration stage during virus production rather than at integration |
| 1BCK | 1998-09-16 | 1.8 | HUMAN CYCLOPHILIN A COMPLEXED WITH 2-THR CYCLOSPORIN |
| 1HWR | 1999-03-23 | 1.8 | MOLECULAR RECOGNITION OF CYCLIC UREA HIV PROTEASE INHIBITORS |
| 1QBR | 1997-10-15 | 1.8 | HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY |
| 1W5V | 2004-12-01 | 1.8 | HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor |
| 4CIF | 2014-01-08 | 1.8 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 1EC3 | 2002-06-26 | 1.8 | HIV-1 protease in complex with the inhibitor MSA367 |
| 4E92 | 2012-04-25 | 1.8 | Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BM4 |
| 3JW2 | 2009-12-08 | 1.8 | HIV-1 Protease Mutant G86S with DARUNAVIR |
| 4CEA | 2013-11-20 | 1.8 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 4K4R | 2013-09-18 | 1.8 | TL-3 inhibited Trp6Ala HIV Protease with 1-bromo-2-napthoic acid bound in exosite |
| 4CP7 | 2014-12-10 | 1.8 | Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol |
| 1SP5 | 2005-07-19 | 1.8 | Crystal structure of HIV-1 protease complexed with a product of autoproteolysis |
| 1D4H | 2002-06-26 | 1.81 | HIV-1 Protease in complex with the inhibitor BEA435 |
| 2R38 | 2008-09-02 | 1.81 | I84V HIV-1 protease mutant in complex with a carbamoyl decorated pyrrolidine-based inhibitor |
| 1D4J | 2002-06-26 | 1.81 | HIV-1 protease in complex with the inhibitor MSL370 |
| 1D4I | 2002-06-26 | 1.81 | HIV-1 protease in complex with the inhibitor BEA425 |
| 1EBW | 2002-06-26 | 1.81 | HIV-1 protease in complex with the inhibitor BEA322 |
| 5HRP | 2016-12-14 | 1.81 | HIV Integrase Catalytic Domain containing F185K + A124T mutations complexed with GSK0002 |
| 4EP3 | 2012-06-06 | 1.81 | Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate CA-p2 |
| 4OJR | 2014-06-11 | 1.82 | Crystal Structure of the HIV-1 Integrase catalytic domain with GSK1264 |
| 4CPU | 2014-12-17 | 1.82 | Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol |
| 6OOT | 2019-08-21 | 1.82 | HIV-1 Protease NL4-3 L89V, L90M Mutant in complex with darunavir |
| 3BC4 | 2008-09-02 | 1.82 | I84V HIV-1 protease in complex with a pyrrolidine diester |
| 4QJ9 | 2014-10-29 | 1.83 | Crystal structure of inactive HIV-1 protease in complex with p1-p6 substrate variant (R452S) |
| 1IIQ | 2002-04-12 | 1.83 | CRYSTAL STRUCTURE OF HIV-1 PROTEASE COMPLEXED WITH A HYDROXYETHYLAMINE PEPTIDOMIMETIC INHIBITOR |
| 3GI6 | 2010-03-09 | 1.84 | Crystal structure of protease inhibitor, AD78 in complex with wild type HIV-1 protease |
| 5TC2 | 2018-04-04 | 1.84 | C-terminal domain of HIV-1 integrase, crystal structure |
| 2QI7 | 2008-04-22 | 1.85 | Crystal structure of protease inhibitor, MIT-2-AD86 in complex with wild type HIV-1 protease |
| 1B6M | 2000-01-07 | 1.85 | HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 6 |
| 3NU9 | 2010-08-25 | 1.85 | Crystal Structure of HIV-1 Protease Mutant I84V with Antiviral Drug Amprenavir |
| 4CK2 | 2014-01-22 | 1.85 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 4OBH | 2014-11-26 | 1.85 | Crystal Structure of Inactive HIV-1 Protease in Complex with the p1-p6 substrate variant (L449F) |
| 1FF0 | 2001-06-01 | 1.85 | STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES. |
| 2QHY | 2008-04-22 | 1.85 | Crystal Structure of protease inhibitor, MIT-1-AC86 in complex with wild type HIV-1 protease |
| 6PJH | 2020-07-01 | 1.85 | HIV-1 Protease NL4-3 WT in Complex with LR3-28 |
| 1Z1R | 2005-03-22 | 1.85 | HIV-1 protease complexed with Macrocyclic peptidomimetic inhibitor 2 |
| 2PYN | 2008-02-26 | 1.85 | HIV-1 PR mutant in complex with nelfinavir |
| 2QI5 | 2008-04-22 | 1.85 | Crystal structure of protease inhibitor, MIT-2-KC08 in complex with wild type HIV-1 protease |
| 2QHZ | 2008-04-22 | 1.85 | Crystal structure of protease inhibitor, MIT-1-AC87 in complex with wild type HIV-1 protease |
| 4Q1W | 2015-02-18 | 1.85 | Mutations Outside the Active Site of HIV-1 Protease Alter Enzyme Structure and Dynamic Ensemble of the Active Site to Confer Drug Resistance |
| 4F76 | 2013-05-15 | 1.85 | Crystal Structure of the active HIV-1 Protease in Complex with the products of p1-p6 substrate |
| 4COP | 2014-06-04 | 1.85 | HIV-1 capsid C-terminal domain mutant (Y169S) |
| 4CPX | 2014-12-17 | 1.85 | Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol |
| 3MXE | 2010-11-10 | 1.85 | Crystal structure of HIV-1 protease inhibitor, KC32 complexed with wild-type protease |
| 1FG8 | 2001-06-01 | 1.85 | STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES |
| 3GI4 | 2010-03-09 | 1.85 | Crystal structure of protease inhibitor, KB60 in complex with wild type HIV-1 protease |
| 1Z1H | 2005-03-22 | 1.85 | HIV-1 protease complexed with macrocyclic peptidomimetic inhibitor 3 |
| 1D4K | 2000-10-11 | 1.85 | HIV-1 PROTEASE COMPLEXED WITH A MACROCYCLIC PEPTIDOMIMETIC INHIBITOR |
| 3AVB | 2012-01-18 | 1.85 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
| 2FNS | 2006-09-05 | 1.85 | Crystal structure of wild-type inactive (D25N) HIV-1 protease complexed with wild-type HIV-1 NC-p1 substrate. |
| 4CES | 2013-11-20 | 1.85 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 4CF0 | 2013-11-20 | 1.85 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 2QI6 | 2008-04-22 | 1.85 | Crystal structure of protease inhibitor, MIT-2-KB98 in complex with wild type HIV-1 protease |
| 1B6K | 2000-01-07 | 1.85 | HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 5 |
| 4KFB | 2013-05-15 | 1.85 | HIV-1 reverse transcriptase with bound fragment at NNRTI adjacent site |
| 1B6J | 2000-01-07 | 1.85 | HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 1 |
| 3DLK | 2008-10-07 | 1.85 | Crystal Structure of an engineered form of the HIV-1 Reverse Transcriptase, RT69A |
| 6D0D | 2019-05-01 | 1.85 | X-ray crystal structure of wild type HIV-1 protease in complex with GRL-087-13 |
| 1CWO | 1998-08-12 | 1.86 | HUMAN CYCLOPHILIN A COMPLEXED WITH THR2, LEU5, D-HIV8, LEU10 CYCLOSPORIN |
| 5HRS | 2016-12-14 | 1.86 | HIV Integrase Catalytic Domain containing F185K + A124N + T125A mutations complexed with GSK0002 |
| 1CWC | 1996-01-29 | 1.86 | IMPROVED BINDING AFFINITY FOR CYCLOPHILIN A BY A CYCLOSPORIN DERIVATIVE SINGLY MODIFIED AT ITS EFFECTOR DOMAIN |
| 6OXT | 2019-08-21 | 1.86 | HIV-1 Protease NL4-3 WT in Complex with LR-84 |
| 1CWH | 1998-07-15 | 1.86 | HUMAN CYCLOPHILIN A COMPLEXED WITH 3-D-SER CYCLOSPORIN |
| 1CWF | 1998-07-15 | 1.86 | HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL CYCLOSPORIN |
| 6OXU | 2019-08-21 | 1.86 | HIV-1 Protease NL4-3 WT in Complex with LR-99 |
| 4ID1 | 2013-05-01 | 1.87 | HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor |
| 3AVM | 2012-01-18 | 1.88 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
| 3AVL | 2012-01-18 | 1.88 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
| 1DW6 | 2000-07-26 | 1.88 | Structural and kinetic analysis of drug resistant mutants of HIV-1 protease |
| 5HRR | 2016-12-14 | 1.88 | HIV Integrase Catalytic Domain containing F185K + A124N + T125S mutations complexed with GSK0002 |
| 3AVH | 2012-01-18 | 1.88 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
| 2XV6 | 2011-10-12 | 1.89 | Crystal structure of the HIV-1 capsid protein C-terminal domain (146- 220) in complex with a camelid VHH. |
| 6PJD | 2020-07-01 | 1.89 | HIV-1 Protease NL4-3 WT in Complex with LR2-32 |
| 6OXQ | 2019-08-21 | 1.89 | HIV-1 Protease NL4-3 WT in Complex with UMass8 |
| 4N1P | 2015-08-12 | 1.9 | Structure of Cyclophilin A in complex with Picolinamide. |
| 3R4B | 2011-09-21 | 1.9 | Crystal Structure of Wild-type HIV-1 Protease in Complex With TMC310911 |
| 1FFF | 2001-06-01 | 1.9 | STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE : HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES. |
| 1W5Y | 2004-10-07 | 1.9 | HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor |
| 4CFC | 2013-11-27 | 1.9 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 1MES | 1998-04-15 | 1.9 | HIV-1 MUTANT (I84V) PROTEASE COMPLEXED WITH DMP323 |
| 4F73 | 2013-05-15 | 1.9 | Crystal Structure of active HIV-1 Protease in Complex with the N terminal product of CA-p2 cleavage site |
| 4EP2 | 2012-06-06 | 1.9 | Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate RT-RH |
| 2WL0 | 2009-12-15 | 1.9 | HIV-1 Protease Inhibitors Containing a Tertiary Alcohol in the Transition-State Mimic with Improved Cell-Based Antiviral Activity |
| 6PJI | 2020-07-01 | 1.9 | HIV-1 Protease NL4-3 WT in Complex with LR3-43 |
| 1HPV | 1995-03-31 | 1.9 | CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH VX-478, A POTENT AND ORALLY BIOAVAILABLE INHIBITOR OF THE ENZYME |
| 1CWI | 1998-08-12 | 1.9 | HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL 3-(N-METHYL)-D-ALANINE CYCLOSPORIN |
| 3BGB | 2008-09-02 | 1.9 | HIV-1 protease in complex with a isobutyl decorated oligoamine |
| 3NWX | 2011-11-02 | 1.9 | X-ray structure of ester chemical analogue [O-Ile50,O-Ile50']HIV-1 protease complexed with KVS-1 inhibitor |
| 4CJF | 2014-01-08 | 1.9 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 6C0O | 2018-08-01 | 1.9 | Crystal structure of HIV-1 K103N mutant reverse transcriptase in complex with non-nucleoside inhibitor 25a |
| 4AHR | 2012-12-19 | 1.9 | Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification |
| 3CYH | 1996-07-11 | 1.9 | CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE SER-PRO |
| 1BWA | 1998-10-30 | 1.9 | HIV-1 PROTEASE (V82F/I84V) DOUBLE MUTANT COMPLEXED WITH XV638 OF DUPONT PHARMACEUTICALS |
| 3NF8 | 2011-04-27 | 1.9 | Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design |
| 4DQF | 2012-03-07 | 1.9 | Crystal Structure of (G16A/L38A) HIV-1 Protease in Complex with DRV |
| 2PYM | 2008-02-26 | 1.9 | HIV-1 PR mutant in complex with nelfinavir |
| 1M9D | 2003-05-27 | 1.9 | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) O-type chimera Complex. |
| 4CHP | 2013-12-11 | 1.9 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 4DGA | 2012-02-08 | 1.9 | TRIMCyp cyclophilin domain from Macaca mulatta: HIV-1 CA(O-loop) complex |
| 1MT7 | 2003-01-07 | 1.9 | Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy |
| 2GON | 2006-09-26 | 1.9 | Xray Structure of Gag133-278 |
| 4QGI | 2014-07-16 | 1.9 | X-ray crystal structure of HIV-1 protease variant G48T/L89M in complex with Saquinavir |
| 2AID | 1997-10-15 | 1.9 | STRUCTURE OF A NON-PEPTIDE INHIBITOR COMPLEXED WITH HIV-1 PROTEASE: DEVELOPING A CYCLE OF STRUCTURE-BASED DRUG DESIGN |
| 4OBD | 2014-11-26 | 1.9 | Crystal Structure of Nelfinavir-Resistant, Inactive HIV-1 Protease (D30N/N88D) in Complex with the p1-p6 substrate variant (L449F/S451N) |
| 6BJ3 | 2018-07-25 | 1.9 | TCR55 in complex with HIV(Pol448-456)/HLA-B35 |
| 2ALF | 2005-08-23 | 1.9 | crystal structure of human CypA mutant K131A |
| 3H47 | 2009-06-23 | 1.9 | X-ray Structure of Hexameric HIV-1 CA |
| 3NF6 | 2011-04-27 | 1.9 | Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design |
| 2ZYE | 2009-03-24 | 1.9 | Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by Neutron Crystallography |
| 4CJE | 2014-01-08 | 1.9 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 1SGU | 2004-10-05 | 1.9 | Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease |
| 1MER | 1998-04-15 | 1.9 | HIV-1 MUTANT (I84V) PROTEASE COMPLEXED WITH DMP450 |
| 1W5X | 2004-12-22 | 1.9 | HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor |
| 3MGE | 2010-07-21 | 1.9 | X-ray Structure of Hexameric HIV-1 CA |
| 2PWM | 2007-09-25 | 1.9 | Crystal Structure of HIV-1 CA146 A92E real cell |
| 6OOS | 2019-08-21 | 1.9 | HIV-1 Protease NL4-3 L90M Mutant in complex with darunavir |
| 1MEU | 1998-04-15 | 1.9 | HIV-1 MUTANT (V82F, I84V) PROTEASE COMPLEXED WITH DMP323 |
| 4CEO | 2013-11-20 | 1.9 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 1M9Y | 2003-05-27 | 1.9 | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,G89A Complex. |
| 4NYF | 2014-06-25 | 1.9 | HIV integrase in complex with inhibitor |
| 1MET | 1998-04-15 | 1.9 | HIV-1 MUTANT (V82F) PROTEASE COMPLEXED WITH DMP323 |
| 1FGC | 2001-06-01 | 1.9 | STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES |
| 5HGN | 2016-08-10 | 1.9 | Hexameric HIV-1 CA, apo form |
| 5TSX | 2017-11-08 | 1.9 | HIV-1 CA hexamer with NUP153 peptide - P1 crystal form |
| 1G6L | 2000-11-15 | 1.9 | 1.9A CRYSTAL STRUCTURE OF TETHERED HIV-1 PROTEASE |
| 4Q1X | 2015-02-18 | 1.9 | Mutations Outside the Active Site of HIV-1 Protease Alter Enzyme Structure and Dynamic Ensemble of the Active Site to Confer Drug Resistance |
| 4AHU | 2012-12-19 | 1.9 | Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification |
| 2BPY | 1999-02-23 | 1.9 | HIV-1 protease-inhibitor complex |
| 6ES8 | 2018-08-15 | 1.9 | HIV capsid hexamer with IP6 ligand |
| 4G9F | 2013-03-20 | 1.9 | Crystal Structure of C12C TCR-HLAB2705-KK10-L6M |
| 4E1M | 2012-04-25 | 1.9 | Crystal Structure of HIV-1 Integrase with a non-catayltic site inhibitor |
| 2BPV | 1999-02-23 | 1.9 | HIV-1 protease-inhibitor complex |
| 2R3W | 2008-09-02 | 1.92 | I84V HIV-1 protease in complex with a amino decorated pyrrolidine-based inhibitor |
| 6C0J | 2018-08-01 | 1.92 | Crystal structure of HIV-1 reverse transcriptase in complex with non-nucleoside inhibitor K-5a2 |
| 6PJE | 2020-07-01 | 1.92 | HIV-1 Protease NL4-3 WT in Complex with LR2-43 |
| 4U1I | 2015-04-08 | 1.92 | HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential HIV-1 escape through identical epitopes |
| 4Y1D | 2015-05-13 | 1.93 | Cyclic hexapeptide cyc[NdPopPKID] in complex with HIV-1 integrase core domain |
| 6PJM | 2020-07-01 | 1.93 | HIV-1 Protease NL4-3 WT in Complex with LR2-35 |
| 1ZJ7 | 2006-05-09 | 1.93 | Crystal structure of a complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[S-CH(OH)CH2NH]-PHE-GLU-PHE-NH2 |
| 6CGF | 2018-08-01 | 1.94 | Crystal structure of HIV-1 Y188L mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2 |
| 6PJF | 2020-07-01 | 1.94 | HIV-1 Protease NL4-3 WT in Complex with LR2-44 |
| 6GJP | 2018-11-07 | 1.94 | Cyclophilin A complexed with tri-vector ligand 7. |
| 6C8Y | 2018-12-05 | 1.94 | D30N HIV-1 protease in complex with a phenylboronic acid (P2') analog of darunavir |
| 4DQC | 2012-03-07 | 1.94 | Crystal Structure of (G16C/L38C) HIV-1 Protease in Complex with DRV |
| 2QI3 | 2008-04-22 | 1.95 | Crystal structure of protease inhibitor, MIT-2-AD94 in complex with wild type HIV-1 protease |
| 1BIZ | 1998-08-19 | 1.95 | HIV-1 INTEGRASE CORE DOMAIN |
| 3NF9 | 2011-04-27 | 1.95 | Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design |
| 4CJW | 2014-01-22 | 1.95 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 4CF1 | 2013-12-18 | 1.95 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 1BIS | 1998-08-19 | 1.95 | HIV-1 INTEGRASE CORE DOMAIN |
| 6D0E | 2019-05-01 | 1.95 | X-ray crystal structure of wild type HIV-1 protease in complex with GRL-084-13 |
| 3LZS | 2010-08-11 | 1.95 | Crystal Structure of HIV-1 CRF01_AE Protease in Complex with Darunavir |
| 2X2D | 2010-03-23 | 1.95 | acetyl-CypA:HIV-1 N-term capsid domain complex |
| 1G2K | 2001-06-01 | 1.95 | HIV-1 PROTEASE WITH CYCLIC SULFAMIDE INHIBITOR, AHA047 |
| 5HGP | 2016-10-19 | 1.95 | Hexameric HIV-1 CA in complex with hexacarboxybenzene |
| 4HLA | 2013-07-24 | 1.95 | Crystal structure of wild type HIV-1 protease in complex with darunavir |
| 3OXW | 2011-09-28 | 1.95 | Crystal Structure of HIV-1 I50V, A71V Protease in Complex with the Protease Inhibitor Darunavir |
| 4CFB | 2013-11-27 | 1.95 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 3ZT3 | 2012-07-11 | 1.95 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
| 4ID5 | 2013-02-06 | 1.95 | HIV-1 reverse transcriptase with bound fragment at the RNase H primer grip site |
| 3ZSX | 2012-07-11 | 1.95 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
| 4CHQ | 2013-12-11 | 1.95 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 3ZT0 | 2012-07-11 | 1.95 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
| 4XRQ | 2015-07-15 | 1.95 | Disulfide stabilized HIV-1 CA hexamer 4mut (S41A, Q67H, V165I, L172I) in complex with PF-3450074 |
| 6PJO | 2020-07-01 | 1.95 | HIV-1 Protease NL4-3 WT in Complex with LR2-42 |
| 6C0L | 2018-08-01 | 1.95 | Crystal structure of HIV-1 E138K mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2 |
| 4KO0 | 2013-08-14 | 1.95 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH an anilinylpyrimidine derivative (JLJ-135) |
| 4CJV | 2014-01-22 | 1.95 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 3MXD | 2010-11-10 | 1.95 | Crystal structure of HIV-1 protease inhibitor KC53 in complex with wild-type protease |
| 4CF2 | 2013-11-20 | 1.95 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 3LPU | 2010-05-12 | 1.95 | HIV integrase |
| 3NFA | 2011-04-27 | 1.95 | Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design |
| 4IG3 | 2013-02-06 | 1.95 | HIV-1 reverse transcriptase with bound fragment near Knuckles site |
| 4CJ5 | 2014-01-08 | 1.95 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 4LQW | 2013-08-14 | 1.95 | Crystal structure of HIV-1 capsid N-terminal domain in complex with NUP358 cyclophilin |
| 6OXY | 2019-08-21 | 1.96 | HIV-1 Protease NL4-3 WT in Complex with LR2-19 |
| 6OXZ | 2019-08-21 | 1.96 | HIV-1 Protease NL4-3 WT in Complex with LR2-20 |
| 6OXX | 2019-08-21 | 1.96 | HIV-1 Protease NL4-3 WT in Complex with LR2-18 |
| 4I8W | 2013-07-24 | 1.96 | Crystal structure of wild type HIV-1 protease in complex with non-peptidic inhibitor, GRL007 |
| 6DUF | 2018-08-01 | 1.96 | Crystal structure of HIV-1 reverse transcriptase V106A/F227L mutant in complex with non-nucleoside inhibitor 25a |
| 6C0K | 2018-08-01 | 1.96 | Crystal structure of HIV-1 K103N mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2 |
| 3EKT | 2009-09-01 | 1.97 | Crystal Structure of the inhibitor Darunavir (DRV) in complex with a multi-drug resistant HIV-1 protease variant (L10F/G48V/I54V/V64I/V82A) (Refer: FLAP+ in citation.) |
| 6PJC | 2020-07-01 | 1.97 | HIV-1 Protease NL4-3 WT in Complex with LR4-41 |
| 1D4Y | 1999-10-13 | 1.97 | HIV-1 PROTEASE TRIPLE MUTANT/TIPRANAVIR COMPLEX |
| 6OXP | 2019-08-21 | 1.97 | HIV-1 Protease NL4-3 WT in Complex with UMass3 |
| 3EKX | 2009-09-01 | 1.97 | Crystal structure of the wild-type HIV-1 protease with the inhibitor, Nelfinavir |
| 6OXW | 2019-08-21 | 1.98 | HIV-1 Protease NL4-3 WT in Complex with LR-100 |
| 1ZSF | 2006-04-25 | 1.98 | Crystal Structure of Complex of a Hydroxyethylamine Inhibitor with HIV-1 Protease at 2.0A Resolution |
| 6PJB | 2020-07-01 | 1.98 | HIV-1 Protease NL4-3 WT in Complex with Lopinavir |
| 6PJN | 2020-07-01 | 1.98 | HIV-1 Protease NL4-3 WT in Complex with LR2-41 |
| 6BHS | 2018-08-01 | 1.98 | HIV-1 CA hexamer in complex with IP6, hexagonal crystal form |
| 3LRY | 2010-03-09 | 1.98 | Crystal structure of synthetic HIV-1 capsid C-terminal domain (CCA) |
| 6OY2 | 2019-08-21 | 1.99 | HIV-1 Protease NL4-3 WT in Complex with LR2-25 |
| 6PJL | 2020-07-01 | 1.99 | HIV-1 Protease NL4-3 WT in Complex with LR3-95 |
| 6OXV | 2019-08-21 | 1.99 | HIV-1 Protease NL4-3 WT in Complex with LR-85 |
| 6OXS | 2019-08-21 | 1.99 | HIV-1 Protease NL4-3 WT in Complex with LR-76 |
| 1F7A | 2001-06-27 | 2.0 | HOW DOES A SYMMETRIC DIMER RECOGNIZE AN ASYMMETRIC SUBSTRATE? A SUBSTRATE COMPLEX OF HIV-1 PROTEASE. |
| 1AJX | 1997-09-17 | 2.0 | HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC UREA INHIBITOR AHA001 |
| 4JMU | 2013-10-30 | 2.0 | Crystal structure of HIV matrix residues 1-111 in complex with inhibitor |
| 2FGU | 2006-11-07 | 2.0 | X-ray crystal structure of HIV-1 Protease T80S variant in complex with the inhibitor saquinavir used to explore the role of invariant Thr80 in HIV-1 protease structure, function, and viral infectivity. |
| 2QI1 | 2008-04-22 | 2.0 | Crystal structure of protease inhibitor, MIT-1-KK81 in complex with wild type HIV-1 protease |
| 6DUH | 2018-08-01 | 2.0 | Crystal structure of HIV-1 reverse transcriptase Y181I mutant in complex with non-nucleoside inhibitor 25a |
| 1A30 | 1998-04-29 | 2.0 | HIV-1 PROTEASE COMPLEXED WITH A TRIPEPTIDE INHIBITOR |
| 1M9C | 2003-05-27 | 2.0 | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type Complex. |
| 6B2K | 2018-09-26 | 2.0 | E45A/R132T mutant of HIV-1 capsid protein |
| 1MT9 | 2003-01-07 | 2.0 | Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy |
| 4QJ8 | 2014-10-29 | 2.0 | Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with p1-p6 substrate variant (P453L) |
| 1A94 | 1999-01-13 | 2.0 | STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES |
| 1B6P | 2000-01-07 | 2.0 | HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 7 |
| 1A8K | 1999-01-13 | 2.0 | CRYSTALLOGRAPHIC ANALYSIS OF HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEASE WITH AN ANALOG OF THE CONSERVED CA-P2 SUBSTRATE: INTERACTIONS WITH FREQUENTLY OCCURRING GLUTAMIC ACID RESIDUE AT P2' POSITION OF SUBSTRATES |
| 3LPT | 2010-05-12 | 2.0 | HIV integrase |
| 2NXD | 2007-09-18 | 2.0 | Structure of HIV-1 protease D25N complexed with rt-rh analogue peptide GLY-ALA-ASP-ILE-PHE*TYR-LEU-ASP-GLY-ALA |
| 6H09 | 2018-08-15 | 2.0 | HIV capsid hexamer with IP6 ligand |
| 1CWM | 1998-07-15 | 2.0 | HUMAN CYCLOPHILIN A COMPLEXED WITH 4 MEILE CYCLOSPORIN |
| 1HVJ | 1994-04-30 | 2.0 | INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE |
| 1AJV | 1997-08-20 | 2.0 | HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006 |
| 4FE6 | 2012-07-18 | 2.0 | Crystal Structure of HIV-1 Protease in Complex with an enamino-oxindole inhibitor |
| 1NPW | 2003-02-04 | 2.0 | Crystal structure of HIV protease complexed with LGZ479 |
| 1TSQ | 2005-03-29 | 2.0 | CRYSTAL STRUCTURE OF AP2V SUBSTRATE VARIANT OF NC-P1 DECAMER PEPTIDE IN COMPLEX WITH V82A/D25N HIV-1 PROTEASE MUTANT |
| 1ODX | 1997-04-01 | 2.0 | HIV-1 Proteinase mutant A71T, V82A |
| 4CJP | 2014-01-08 | 2.0 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 1BV9 | 1998-09-30 | 2.0 | HIV-1 PROTEASE (I84V) COMPLEXED WITH XV638 OF DUPONT PHARMACEUTICALS |
| 2XYE | 2011-12-07 | 2.0 | HIV-1 Inhibitors with a Tertiary-Alcohol-containing Transition-State Mimic and various P2 and P1 prime Substituents |
| 6PJK | 2020-07-01 | 2.0 | HIV-1 Protease NL4-3 WT in Complex with LR3-29 |
| 1NPV | 2003-02-04 | 2.0 | Crystal structure of HIV-1 protease complexed with LDC271 |
| 1DMP | 1997-11-12 | 2.0 | STRUCTURE OF HIV-1 PROTEASE COMPLEX |
| 1HPX | 1996-03-08 | 2.0 | HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR KNI-272 |
| 1MRW | 2003-11-04 | 2.0 | Structure of HIV protease (Mutant Q7K L33I L63I) complexed with KNI-577 |
| 5VJ3 | 2018-04-18 | 2.0 | HIV Protease (PR) in open form with Mg2+ in active site and HIVE-9 in eye site |
| 1ODY | 1999-02-16 | 2.0 | HIV-1 PROTEASE COMPLEXED WITH AN INHIBITOR LP-130 |
| 2NXL | 2007-09-18 | 2.0 | Structure of HIV-1 protease D25N complexed with the rt-rh analogue peptide GLY-ALA-GLU-VAL-PHE*TYR-VAL-ASP-GLY-ALA |
| 1KJ7 | 2002-03-06 | 2.0 | SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES |
| 1BL3 | 1998-09-30 | 2.0 | CATALYTIC DOMAIN OF HIV-1 INTEGRASE |
| 1HIV | 1993-10-31 | 2.0 | CRYSTAL STRUCTURE OF A COMPLEX OF HIV-1 PROTEASE WITH A DIHYDROETHYLENE-CONTAINING INHIBITOR: COMPARISONS WITH MOLECULAR MODELING |
| 3EL0 | 2009-09-01 | 2.0 | Crystal structure of the inhibitor Nelfinavir (NFV) in complex with a multi-drug resistant HIV-1 protease variant (L10I/G48V/I54V/V64I/V82A) (Refer: FLAP+ in citation) |
| 1ZBG | 2006-04-18 | 2.0 | Crystal structure of a complex of mutant hiv-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2 |
| 6OY0 | 2019-08-21 | 2.0 | HIV-1 Protease NL4-3 WT in Complex with LR2-21 |
| 2O4N | 2006-12-12 | 2.0 | Crystal Structure of HIV-1 Protease (TRM Mutant) in Complex with Tipranavir |
| 2Q3K | 2007-08-21 | 2.0 | Crystal Structure of Lysine Sulfonamide Inhibitor Reveals the Displacement of the Conserved Flap Water Molecule in HIV-1 Protease |
| 1EC2 | 2002-06-26 | 2.0 | HIV-1 protease in complex with the inhibitor BEA428 |
| 6C0N | 2018-08-01 | 2.0 | Crystal structure of HIV-1 reverse transcriptase in complex with non-nucleoside inhibitor 25a |
| 6V2F | 2020-07-01 | 2.0 | Crystal structure of the HIV capsid hexamer bound to the small molecule long-acting inhibitor, GS-6207 |
| 5NOV | 2017-07-12 | 2.0 | Structure of cyclophilin A in complex with hexahydropyrimidine-2-thione |
| 5HVP | 1991-10-15 | 2.0 | CRYSTALLOGRAPHIC ANALYSIS OF A COMPLEX BETWEEN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AND ACETYL-PEPSTATIN AT 2.0-ANGSTROMS RESOLUTION |
| 6J1V | 2019-09-25 | 2.0 | The structure of HLA-A*3003/RT313 |
| 4CGD | 2013-12-04 | 2.0 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 4CHN | 2013-12-11 | 2.0 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 7UPJ | 1997-04-21 | 2.0 | HIV-1 PROTEASE/U101935 COMPLEX |
| 4QNB | 2014-12-31 | 2.0 | Disulfide stabilized HIV-1 CA hexamer in complex with PHENYL-L-PHENYLALANINAMIDE inhibitor |
| 1AXA | 1998-04-15 | 2.0 | ACTIVE-SITE MOBILITY IN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AS DEMONSTRATED BY CRYSTAL STRUCTURE OF A28S MUTANT |
| 1NPA | 2004-01-27 | 2.0 | crystal structure of HIV-1 protease-hup |
| 1MSM | 2003-11-04 | 2.0 | The HIV protease (mutant Q7K L33I L63I) complexed with KNI-764 (an inhibitor) |
| 5T9W | 2017-01-25 | 2.0 | Discovery of a Potent Cyclophilin Inhibitor (Compound 5) based on Structural Simplification of Sanglifehrin A |
| 1BV7 | 1998-09-30 | 2.0 | COUNTERACTING HIV-1 PROTEASE DRUG RESISTANCE: STRUCTURAL ANALYSIS OF MUTANT PROTEASES COMPLEXED WITH XV638 AND SD146, CYCLIC UREA AMIDES WITH BROAD SPECIFICITIES |
| 1HTG | 1994-07-31 | 2.0 | X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE |
| 1KJF | 2002-03-06 | 2.0 | SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES |
| 1KJH | 2002-03-06 | 2.0 | SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES |
| 1HSG | 1996-04-03 | 2.0 | CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES |
| 5V5L | 2017-06-14 | 2.0 | Crystal structure of HLA-B*5801 complex with HIV-1 gag derived peptide TW10 |
| 4E1N | 2012-04-25 | 2.0 | Crystal Structure of HIV-1 Integrase with a non-catayltic site inhibitor |
| 5VEA | 2018-04-25 | 2.0 | HIV Protease (PR) with TL-3 in active site and 4-methylbenzene-1,2-diamine in exosite |
| 1RL8 | 2005-04-19 | 2.0 | Crystal structure of the complex of resistant strain of hiv-1 protease(v82a mutant) with ritonavir |
| 1KJG | 2002-03-06 | 2.0 | SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES |
| 1VBS | 1999-01-13 | 2.0 | STRUCTURE OF CYCLOPHILIN COMPLEXED WITH (D)ALA CONTAINING TETRAPEPTIDE |
| 2AZ8 | 2006-02-28 | 2.0 | HIV-1 Protease NL4-3 in complex with inhibitor, TL-3 |
| 1MSN | 2003-11-04 | 2.0 | The HIV protease (mutant Q7K L33I L63I V82F I84V) complexed with KNI-764 (an inhibitor) |
| 5T6Z | 2017-03-01 | 2.0 | KIR3DL1 in complex with HLA-B*57:01-TW10 |
| 3DOX | 2008-09-09 | 2.0 | X-ray structure of HIV-1 protease in situ product complex |
| 3OUC | 2011-03-30 | 2.0 | MDR769 HIV-1 protease complexed with p2/NC hepta-peptide |
| 5HGO | 2016-08-10 | 2.0 | Hexameric HIV-1 CA R18G mutant |
| 2AQU | 2006-08-29 | 2.0 | Structure of HIV-1 protease bound to atazanavir |
| 6OY1 | 2019-08-21 | 2.0 | HIV-1 Protease NL4-3 WT in Complex with LR2-26 |
| 6OXO | 2019-08-21 | 2.0 | HIV-1 Protease NL4-3 WT in Complex with LR2-91 |
| 3EL4 | 2009-09-01 | 2.0 | Crystal structure of inhibitor saquinavir (SQV) complexed with the multidrug HIV-1 protease variant L63P/V82T/I84V |
| 1MRX | 2003-11-04 | 2.0 | Structure of HIV protease (Mutant Q7K L33I L63I V82F I84V ) complexed with KNI-577 |
| 1K6V | 2002-02-06 | 2.0 | LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE |
| 6CPN | 2018-06-06 | 2.0 | Crystal structure of DR11 presenting the RQ13 peptide |
| 3ZSZ | 2012-07-11 | 2.0 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
| 3TLH | 1998-12-09 | 2.0 | STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITHAN EFFICIENT INHIBITOR OF FIV PR |
| 6EX9 | 2018-06-06 | 2.01 | Crystal Structure of HIV-1 Integrase Catalytic Core Domain with Inhibitor Peptide |
| 1EBZ | 2002-06-26 | 2.01 | HIV-1 protease in complex with the inhibitor BEA388 |
| 2AZC | 2006-02-28 | 2.01 | HIV-1 Protease NL4-3 6X mutant |
| 4XRO | 2015-07-15 | 2.01 | Disulfide stabilized HIV-1 CA hexamer 4mut (S41A, Q67H, V165I, L172I) |
| 3DPH | 2008-09-02 | 2.01 | HIV-1 capsid C-terminal domain mutant (L211S) |
| 1B92 | 1999-07-19 | 2.02 | MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY |
| 1ZPA | 2005-05-31 | 2.02 | HIV Protease with Scripps AB-3 Inhibitor |
| 2B4J | 2005-10-25 | 2.02 | Structural basis for the recognition between HIV-1 integrase and LEDGF/p75 |
| 2AZB | 2006-02-28 | 2.03 | HIV-1 Protease NL4-3 3X mutant in complex with inhibitor, TL-3 |
| 4U0E | 2014-11-12 | 2.04 | Hexameric HIV-1 CA in complex with PF3450074 |
| 6OXR | 2019-08-21 | 2.04 | HIV-1 Protease NL4-3 WT in Complex with LR-82 |
| 3K2P | 2010-02-09 | 2.04 | HIV-1 Reverse Transcriptase Isolated RnaseH Domain with the Inhibitor beta-thujaplicinol Bound at the Active Site |
| 5HGM | 2016-08-10 | 2.04 | Hexameric HIV-1 CA in complex with dATP |
| 6C0R | 2018-08-01 | 2.05 | Crystal structure of HIV-1 K103N/Y181C mutant reverse transcriptase in complex with non-nucleoside inhibitor 25a |
| 6OMT | 2019-08-21 | 2.05 | HIV-1 capsid hexamer R18D mutant |
| 1CPI | 1996-03-08 | 2.05 | REGIOSELECTIVE STRUCTURAL AND FUNCTIONAL MIMICRY OF PEPTIDES. DESIGN OF HYDROLYTICALLY STABLE CYCLIC PEPTIDOMIMETIC INHIBITORS OF HIV-1 PROTEASE |
| 4O0J | 2014-07-02 | 2.05 | HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[4-(4-chlorophenyl)-6-(3,4-dimethylphenyl)-2,5-dimethylpyridin-3-yl]ethanoic acid |
| 4CFA | 2013-11-27 | 2.05 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 6C0P | 2018-08-01 | 2.05 | Crystal structure of HIV-1 E138K mutant reverse transcriptase in complex with non-nucleoside inhibitor 25a |
| 4U0A | 2014-11-12 | 2.05 | Hexameric HIV-1 CA in complex with CPSF6 peptide, P6 crystal form |
| 3U7S | 2012-01-18 | 2.05 | HIV PR drug resistant patient's variant in complex with darunavir |
| 5TEO | 2017-09-27 | 2.05 | Dimer of HIV-1 Gag CTD-SP1 fragment |
| 4IFV | 2013-02-06 | 2.05 | Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-Ray Crystallographic Fragment Screening |
| 1ZSR | 2006-04-25 | 2.06 | Crystal structure of wild type HIV-1 protease (BRU isolate) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[S-CH(OH)CH2NH]-PHE-GLU-PHE-NH2 |
| 1EBK | 2000-07-26 | 2.06 | Structural and kinetic analysis of drug resistant mutants of HIV-1 protease |
| 4CGI | 2013-12-04 | 2.07 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 3PSU | 2011-12-07 | 2.07 | HIV-1 protease in complex with an isobutyl decorated oligoamine (symmetric binding mode) |
| 4JLH | 2013-05-01 | 2.09 | HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor |
| 3QIP | 2011-04-20 | 2.09 | Structure of HIV-1 reverse transcriptase in complex with an RNase H inhibitor and nevirapine |
| 5W4O | 2018-06-20 | 2.09 | Structure of the R18A mutant of the HIV-1 capsid protein |
| 4IDK | 2013-02-06 | 2.1 | HIV-1 reverse transcriptase with bound fragment at the 428 site |
| 1CWA | 1996-01-29 | 2.1 | X-RAY STRUCTURE OF A MONOMERIC CYCLOPHILIN A-CYCLOSPORIN A CRYSTAL COMPLEX AT 2.1 ANGSTROMS RESOLUTION |
| 1EC1 | 2002-06-26 | 2.1 | HIV-1 protease in complex with the inhibitor BEA409 |
| 3EM4 | 2009-09-01 | 2.1 | Crystal structure of atazanavir (ATV) in complex with I50L/A71V drug-resistant HIV-1 protease |
| 1TSU | 2005-03-29 | 2.1 | CRYSTAL STRUCTURE OF DECAMER NCP1 SUBSTRATE PEPTIDE IN COMPLEX WITH WILD-TYPE D25N HIV-1 PROTEASE VARIANT |
| 4CE9 | 2013-11-20 | 2.1 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 1LV1 | 2002-06-19 | 2.1 | Crystal Structure Analysis of the non-active site mutant of tethered HIV-1 protease to 2.1A resolution |
| 3AVN | 2012-01-18 | 2.1 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
| 4CF9 | 2013-11-27 | 2.1 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 2RMA | 1995-02-07 | 2.1 | Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A |
| 5CYM | 2015-12-30 | 2.1 | HIV-1 reverse transcriptase complexed with 4-iodopyrazole |
| 4IFY | 2013-02-06 | 2.1 | HIV-1 reverse transcriptase with bound fragment at the Knuckles site |
| 1QS4 | 1999-11-17 | 2.1 | Core domain of HIV-1 integrase complexed with Mg++ and 1-(5-chloroindol-3-yl)-3-hydroxy-3-(2H-tetrazol-5-yl)-propenone |
| 2QI0 | 2008-04-22 | 2.1 | Crystal structure of protease inhibitor, MIT-1-KK80 in complex with wild type HIV-1 protease |
| 5T70 | 2017-03-01 | 2.1 | KIR3DL1 in complex with HLA-B*57:01 presenting TSNLQEQIGW |
| 1QBT | 1997-10-15 | 2.1 | HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY |
| 6OPW | 2019-09-04 | 2.1 | HIV-1 Protease NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, A71V, V82F, I84V Mutant in complex with darunavir |
| 2RMB | 1995-02-07 | 2.1 | Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A |
| 1NMK | 2003-04-01 | 2.1 | The Sanglifehrin-Cyclophilin Interaction: Degradation Work, Synthetic Macrocyclic Analogues, X-ray Crystal Structure and Binding Data |
| 2X4U | 2010-03-02 | 2.1 | Crystal structure of MHC CLass I HLA-A2.1 bound to HIV-1 Peptide RT468-476 |
| 4CYH | 1996-07-11 | 2.1 | CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE HIS-PRO |
| 5CYH | 1996-07-11 | 2.1 | CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE GLY-PRO |
| 1T7K | 2004-10-05 | 2.1 | Crystal Structure of HIV Protease complexed with Arylsulfonamide azacyclic urea |
| 3EM6 | 2009-09-01 | 2.1 | Crystal structure of I50L/A71V mutant of hiv-1 protease in complex with inhibitor darunavir |
| 4PHV | 1993-10-31 | 2.1 | X-RAY CRYSTAL STRUCTURE OF THE HIV PROTEASE COMPLEX WITH L-700,417, AN INHIBITOR WITH PSEUDO C2 SYMMETRY |
| 3T3C | 2012-06-20 | 2.1 | Structure of HIV PR resistant patient derived mutant (comprising 22 mutations) in complex with DRV |
| 4FAF | 2012-08-29 | 2.1 | Substrate CA/p2 in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant |
| 3BGR | 2008-02-12 | 2.1 | Crystal structure of K103N/Y181C mutant HIV-1 reverse transcriptase (RT) in complex with TMC278 (Rilpivirine), a non-nucleoside RT inhibitor |
| 1ODW | 1997-04-01 | 2.1 | Native HIV-1 Proteinase |
| 2YNG | 2013-01-09 | 2.12 | HIV-1 Reverse Transcriptase in complex with inhibitor GSK560 |
| 2YKN | 2011-08-17 | 2.12 | Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with a Difluoromethylbenzoxazole (DFMB) Pyrimidine Thioether derivative, a non-nucleoside RT inhibitor (NNRTI) |
| 6OPY | 2019-09-04 | 2.13 | HIV-1 Protease NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, A71V, L76V, V82F, I84V Mutant in complex with darunavir |
| 5IND | 2016-10-05 | 2.13 | Crystal structure of HLA-B5801, a protective HLA allele for HIV-1 infection |
| 4QJ2 | 2014-10-29 | 2.13 | Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with WT p1-p6 substrate |
| 6OOU | 2019-08-21 | 2.13 | Crystal structure of HIV-1 Protease NL4-3 L89V Mutant in complex with darunavir |
| 3RDD | 2012-03-21 | 2.14 | Human Cyclophilin A Complexed with an Inhibitor |
| 4CFD | 2013-11-27 | 2.15 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 3EKP | 2009-09-01 | 2.15 | Crystal Structure of the inhibitor Amprenavir (APV) in complex with a multi-drug resistant HIV-1 protease variant (L10I/G48V/I54V/V64I/V82A)Refer: FLAP+ in citation |
| 1ZTZ | 2005-11-01 | 2.15 | Crystal structure of HIV protease- metallacarborane complex |
| 1IZI | 2002-12-23 | 2.15 | Inhibitor of HIV protease with unusual binding mode potently inhibiting multi-resistant protease mutants |
| 4CGJ | 2013-12-04 | 2.15 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
| 6JCF | 2019-07-17 | 2.15 | Cryogenic structure of HIV-1 Integrase catalytic core domain by synchrotron |
| 5CYQ | 2015-12-30 | 2.15 | HIV-1 reverse transcriptase complexed with 4-bromopyrazole |
| 3LZV | 2010-08-11 | 2.15 | Structure of Nelfinavir-resistant HIV-1 protease (D30N/N88D) in complex with Darunavir. |
| 1MT8 | 2003-01-07 | 2.15 | Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy |
| 4DG1 | 2012-06-20 | 2.15 | Crystal structure of HIV-1 reverse transcriptase (RT) with polymorphism mutation K172A and K173A |
| 4GVM | 2013-05-01 | 2.16 | HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor |
| 5W4P | 2018-06-20 | 2.19 | Structure of the E28A mutant of the HIV-1 capsid protein |
| 4LH5 | 2013-12-25 | 2.19 | Dual inhibition of HIV-1 replication by Integrase-LEDGF allosteric inhibitors is predominant at post-integration stage during virus production rather than at integration |
| 3DLG | 2008-08-12 | 2.2 | Crystal structure of hiv-1 reverse transcriptase in complex with GW564511. |
| 4F74 | 2013-05-15 | 2.2 | Crystal Structure of active HIV-1 Protease in Complex with the N terminal product of the substrate MA-CA. |
| 5OI2 | 2018-03-07 | 2.2 | Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 |
| 6OPZ | 2019-09-04 | 2.2 | HIV-1 Protease NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, I54L, A71V, L76V, V82F, I84V Mutant in complex with darunavir |
| 3EM3 | 2009-09-01 | 2.2 | Crystal structure of amprenavir (APV) in complex with a drug resistant HIV-1 protease variant (I50L/A71V). |
| 1HIH | 1995-07-10 | 2.2 | COMPARATIVE ANALYSIS OF THE X-RAY STRUCTURES OF HIV-1 AND HIV-2 PROTEASES IN COMPLEX WITH CGP 53820, A NOVEL PSEUDOSYMMETRIC INHIBITOR |
| 1N49 | 2003-01-07 | 2.2 | Viability of a Drug-Resistant HIV-1 Protease Variant: Structural Insights for Better Anti-Viral Therapy |
| 1YTH | 1997-03-12 | 2.2 | SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT |
| 5OIA | 2018-03-07 | 2.2 | Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 |
| 1RTH | 1996-04-03 | 2.2 | HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES |
| 3ODI | 2011-02-16 | 2.2 | Crystal structure of cyclophilin A in complex with Voclosporin E-ISA247 |
| 2Q63 | 2008-02-26 | 2.2 | HIV-1 PR mutant in complex with nelfinavir |
| 1T7J | 2005-05-10 | 2.2 | crystal structure of inhibitor amprenavir in complex with a multi-drug resistant variant of HIV-1 protease (L63P/V82T/I84V) |
| 4DGE | 2012-02-08 | 2.2 | TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant, HIV-1 CA(O-loop) complex |
| 1K6C | 2002-02-06 | 2.2 | LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE |
| 1HEG | 1994-05-31 | 2.2 | The crystal structures at 2.2 angstroms resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations |
| 6ELI | 2018-04-11 | 2.2 | Structure of HIV-1 reverse transcriptase (RT) in complex with rilpivirine and an RNase H inhibitor XZ462 |
| 1HAR | 1995-04-20 | 2.2 | 2.2 ANGSTROMS RESOLUTION STRUCTURE OF THE AMINO-TERMINAL HALF OF HIV-1 REVERSE TRANSCRIPTASE (FINGERS AND PALM SUBDOMAINS) |
| 1AID | 1997-10-15 | 2.2 | STRUCTURE OF A NON-PEPTIDE INHIBITOR COMPLEXED WITH HIV-1 PROTEASE: DEVELOPING A CYCLE OF STRUCTURE-BASED DRUG DESIGN |
| 2QAK | 2008-07-01 | 2.2 | HIV-1 PR mutant in complex with nelfinavir |
| 1Z8C | 2006-03-21 | 2.2 | Crystal structure of the complex of mutant HIV-1 protease (l63P, A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2 |
| 1VRT | 1996-04-03 | 2.2 | HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES |
| 2B7Z | 2006-11-14 | 2.2 | Structure of HIV-1 protease mutant bound to indinavir |
| 1HTF | 1994-07-31 | 2.2 | X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE |
| 3KDC | 2010-03-16 | 2.2 | Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10074 |
| 1U8G | 2004-11-02 | 2.2 | Crystal structure of a HIV-1 Protease in complex with peptidomimetic inhibitor KI2-PHE-GLU-GLU-NH2 |
| 1CWB | 1996-01-29 | 2.2 | THE X-RAY STRUCTURE OF (MEBM2T)1-CYCLOSPORIN COMPLEXED WITH CYCLOPHILIN A PROVIDES AN EXPLANATION FOR ITS ANOMALOUSLY HIGH IMMUNOSUPPRESSIVE ACTIVITY |
| 1BHL | 1998-10-14 | 2.2 | CACODYLATED CATALYTIC DOMAIN OF HIV-1 INTEGRASE |
| 3ZSY | 2012-07-11 | 2.2 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
| 1HEF | 1994-05-31 | 2.2 | The crystal structures at 2.2 angstroms resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations |
| 1K6P | 2002-02-06 | 2.2 | LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE |
| 1LZQ | 2003-04-29 | 2.2 | Crystal structure of the complex of mutant HIV-1 protease (A71V, V82T, I84V) with an ethylenamine peptidomimetic inhibitor BOC-PHE-PSI[CH2CH2NH]-PHE-GLU-PHE-NH2 |
| 3ZT4 | 2012-07-18 | 2.2 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
| 3EKQ | 2009-09-01 | 2.2 | Crystal structure of inhibitor saquinavir (SQV) in complex with multi-drug resistant HIV-1 protease (L63P/V82T/I84V) (referred to as ACT in paper) |
| 1E27 | 2000-09-12 | 2.2 | Nonstandard peptide binding of HLA-B*5101 complexed with HIV immunodominant epitope KM1(LPPVVAKEI) |
| 3UHL | 2012-03-28 | 2.2 | Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with p2-NC substrate analog |
| 1K2C | 2002-07-10 | 2.2 | Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance |
| 6B2J | 2018-09-26 | 2.21 | E45A mutant of HIV-1 capsid protein (other crystal form) |
| 1UPJ | 1996-10-14 | 2.22 | HIV-1 PROTEASE COMPLEX WITH U095438 [3-[1-(4-BROMOPHENYL) ISOBUTYL]-4-HYDROXYCOUMARIN |
| 4U0F | 2014-11-12 | 2.22 | Hexameric HIV-1 CA in Complex with BI-2 |
| 6DUG | 2018-08-01 | 2.22 | Crystal structure of HIV-1 reverse transcriptase K101P mutant in complex with non-nucleoside inhibitor 25a |
| 3T11 | 2012-08-22 | 2.22 | Dimeric inhibitor of HIV-1 protease. |
| 5VQZ | 2017-08-23 | 2.23 | Crystal Structure of HIV-1 Reverse Transcriptase (K103N, Y181C) Variant in Complex with 2-chloro-N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacetamide (JLJ686), a Non-nucleoside Inhibitor |
| 3LP1 | 2010-06-09 | 2.23 | HIV-1 reverse transcriptase with inhibitor |
| 3TTP | 2012-09-26 | 2.23 | Structure of multiresistant HIV-1 protease in complex with darunavir |
| 6UL5 | 2020-02-05 | 2.23 | Crystal structure of HIV-1 reverse transcriptase (RT) in complex with 4-[(4-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy}thieno[3,2-d]pyrimidin-2-yl)amino]-2-fluorobenzonitrile (24b), a non-nucleoside RT inhibitor |
| 4O55 | 2014-07-02 | 2.24 | HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[6-(5-chloro-1H-benzimidazol-2-yl)-2,5-dimethyl-4-phenylpyridin-3-yl]ethanoic acid |
| 1K6T | 2002-02-06 | 2.25 | LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE |
| 3OQA | 2011-04-06 | 2.25 | Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants |
| 1SJH | 2004-08-17 | 2.25 | HLA-DR1 complexed with a 13 residue HIV capsid peptide |
| 3PJ6 | 2011-04-06 | 2.25 | Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants |
| 1HVS | 1995-02-14 | 2.25 | STRUCTURAL BASIS OF DRUG RESISTANCE FOR THE V82A MUTANT OF HIV-1 PROTEASE: BACKBONE FLEXIBILITY AND SUBSITE REPACKING |
| 2NXM | 2007-09-18 | 2.25 | Structure of HIV-1 protease D25N complexed with the rt-rh analogue peptide GLY-ALA-GLN-THR-PHE*TYR-VAL-ASP-GLY-ALA |
| 1EBY | 2002-06-26 | 2.29 | HIV-1 protease in complex with the inhibitor BEA369 |
| 5W4Q | 2018-06-20 | 2.29 | Structure of the R18A/E28A mutant of the HIV-1 capsid protein |
| 5T9U | 2017-01-25 | 2.3 | Discovery of a Potent Cyclophilin Inhibitor (Compound 3) based on Structural Simplification of Sanglifehrin A |
| 1SBG | 1994-10-15 | 2.3 | AN ORALLY-BIOAVAILABLE HIV-1 PROTEASE INHIBITOR CONTAINING AN IMIDAZOLE-DERIVED PEPTIDE BOND REPLACEMENT. CRYSTALLOGRAPHIC AND PHARMACOKINETIC ANALYSIS |
| 3DYA | 2008-11-25 | 2.3 | HIV-1 RT with non-nucleoside inhibitor annulated Pyrazole 1 |
| 4Y1C | 2015-02-25 | 2.3 | Cyclic hexapeptide cyc[NdPopPKID] in complex with HIV-1 integrase core domain |
| 1GNO | 1996-11-08 | 2.3 | HIV-1 PROTEASE (WILD TYPE) COMPLEXED WITH U89360E (INHIBITOR) |
| 5OI3 | 2018-03-07 | 2.3 | Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 |
| 2R5Q | 2007-11-20 | 2.3 | Crystal Structure Analysis of HIV-1 Subtype C Protease Complexed with Nelfinavir |
| 1HYZ | 2001-04-04 | 2.3 | HIV INTEGRASE CORE DOMAIN COMPLEXED WITH A DERIVATIVE OF TETRAPHENYL ARSONIUM. |
| 2OPS | 2007-05-22 | 2.3 | Crystal Structure of Y188C Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X. |
| 1GNM | 1996-11-08 | 2.3 | HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASP (V82D) COMPLEXED WITH U89360E (INHIBITOR) |
| 6AXR | 2018-09-12 | 2.3 | Structure of the P122A mutant of the HIV-1 capsid protein |
| 1YTG | 1997-03-12 | 2.3 | SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT |
| 1A9M | 1998-06-17 | 2.3 | G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E |
| 3LAK | 2010-02-23 | 2.3 | Crystal structure of HIV-1 reverse transcriptase in complex with N1-heterocycle pyrimidinedione non-nucleoside inhibitor |
| 4KV8 | 2013-07-31 | 2.3 | Crystal structure of HIV RT in complex with BILR0355BS |
| 1VBT | 1999-01-13 | 2.3 | Structure of cyclophilin complexed with sulfur-substituted tetrapeptide AAPF |
| 1HPS | 1994-08-31 | 2.3 | RATIONAL DESIGN, SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS OF A HYDROXYETHYLENE-BASED HIV-1 PROTEASE INHIBITOR CONTAINING A HETEROCYCLIC P1'-P2' AMIDE BOND ISOSTERE |
| 4I2P | 2013-01-16 | 2.3 | Crystal structure of HIV-1 reverse transcriptase in complex with rilpivirine (TMC278) based analogue |
| 1HXB | 1997-03-12 | 2.3 | HIV-1 proteinase complexed with RO 31-8959 |
| 6KDN | 2020-03-04 | 2.3 | HIV-1 reverse transcriptase with Q151M/Y115F/F116Y:DNA:dGTP ternary complex |
| 1ITG | 1995-05-08 | 2.3 | CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE: SIMILARITY TO OTHER POLYNUCLEOTIDYL TRANSFERASES |
| 1GNN | 1996-11-08 | 2.3 | HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASN (V82N) COMPLEXED WITH U89360E (INHIBITOR) |
| 2QNQ | 2008-04-15 | 2.3 | HIV-1 Protease in complex with a chloro decorated pyrrolidine-based inhibitor |
| 2R5P | 2007-11-20 | 2.3 | Crystal Structure Analysis of HIV-1 Subtype C Protease Complexed with Indinavir |
| 4HVP | 1990-04-15 | 2.3 | Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 Angstroms resolution |
| 5D3G | 2015-09-30 | 2.3 | Structure of HIV-1 Reverse Transcriptase Bound to a Novel 38-mer Hairpin Template-Primer DNA Aptamer |
| 1HIW | 1996-10-14 | 2.3 | TRIMERIC HIV-1 MATRIX PROTEIN |
| 1TCX | 1996-12-07 | 2.3 | HIV TRIPLE MUTANT PROTEASE COMPLEXED WITH INHIBITOR SB203386 |
| 1ZLF | 2006-04-25 | 2.3 | Crystal structure of a complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor |
| 1HBV | 1995-07-10 | 2.3 | A CHECK ON RATIONAL DRUG DESIGN. CRYSTAL STRUCTURE OF A COMPLEX OF HIV-1 PROTEASE WITH A NOVEL GAMMA-TURN MIMETIC |
| 3MEC | 2010-05-12 | 2.3 | HIV-1 Reverse Transcriptase in Complex with TMC125 |
| 1HOS | 1993-10-31 | 2.3 | INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE BY A C2-SYMMETRIC PHOSPHINATE SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS |
| 2RKI | 2008-04-22 | 2.3 | Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with a triazole derived NNRTI |
| 4K4P | 2013-09-18 | 2.31 | TL-3 inhibited Trp6Ala HIV Protease |
| 3ODL | 2011-02-16 | 2.31 | Crystal structure of cyclophilin A in complex with Voclosporin Z-ISA247 |
| 2Z54 | 2008-07-01 | 2.31 | The Influence of I47A Mutation on Reduced Susceptibility to the Protease Inhibitor Lopinavir |
| 6VLM | 2020-05-13 | 2.32 | Core Catalytic Domain of HIV Integrase in complex with virtual screening hit |
| 6KDM | 2020-03-04 | 2.32 | HIV-1 reverse transcriptase with Q151M/Y115F/F116Y:DNA:entecavir 5'-triphosphate ternary complex |
| 3K0Q | 2009-12-08 | 2.32 | Cryogenic structure of CypA mutant Ser99Thr (2) |
| 6UM8 | 2020-03-04 | 2.33 | HIV Integrase in complex with Compound-14 |
| 1AWV | 1998-03-18 | 2.34 | CYPA COMPLEXED WITH HVGPIA |
| 1AWU | 1998-03-18 | 2.34 | CYPA COMPLEXED WITH HVGPIA (PSEUDO-SYMMETRIC MONOMER) |
| 5KGW | 2016-10-19 | 2.34 | HIV1 catalytic core domain in complex with inhibitor: (2~{S})-2-[3-(3,4-dihydro-2~{H}-chromen-6-yl)-1-methyl-indol-2-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid |
| 5VQY | 2017-08-23 | 2.35 | Crystal Structure of HIV-1 Reverse Transcriptase (K103N, Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacrylamide (JLJ684), a Non-nucleoside Inhibitor |
| 4EJ8 | 2013-05-01 | 2.35 | Apo HIV Protease (PR) dimer in closed form with fragment 1F1 in the outside/top of flap |
| 5OI8 | 2018-03-07 | 2.35 | Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 |
| 1RTJ | 1996-04-03 | 2.35 | MECHANISM OF INHIBITION OF HIV-1 REVERSE TRANSCRIPTASE BY NON-NUCLEOSIDE INHIBITORS |
| 4CPQ | 2014-12-17 | 2.35 | Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol |
| 1AK4 | 1997-10-15 | 2.36 | HUMAN CYCLOPHILIN A BOUND TO THE AMINO-TERMINAL DOMAIN OF HIV-1 CAPSID |
| 2YNF | 2013-01-09 | 2.36 | HIV-1 Reverse Transcriptase Y188L mutant in complex with inhibitor GSK560 |
| 4O5B | 2014-07-02 | 2.37 | HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[6-(5-chloro-1H-benzimidazol-2-yl)-2,5-dimethyl-4-phenylpyridin-3-yl]ethanoic acid |
| 6ECL | 2019-08-21 | 2.38 | Crystal Structure of a 1,2,4-Triazole Allosteric RNase H Inhibitor in Complex with HIV Reverse Transcriptase |
| 5XN2 | 2018-02-07 | 2.38 | HIV-1 reverse transcriptase Q151M:DNA:dGTP ternary complex |
| 6EWA | 2018-11-07 | 2.39 | Crystal structure of HLA-A2 in complex with LILRB1 |
| 1RMH | 1996-10-14 | 2.4 | RECOMBINANT CYCLOPHILIN A FROM HUMAN T CELL |
| 3T1A | 2011-10-26 | 2.4 | Crystal Structure of HIV-1 Reverse Transcriptase (K103N mutant) in Complex with Inhibitor M05 |
| 1K6Y | 2001-12-21 | 2.4 | Crystal Structure of a Two-Domain Fragment of HIV-1 Integrase |
| 1Q94 | 2004-06-01 | 2.4 | Structures of HLA-A*1101 in complex with immunodominant nonamer and decamer HIV-1 epitopes clearly reveal the presence of a middle anchor residue |
| 1VRU | 1996-04-03 | 2.4 | HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES |
| 5K14 | 2016-06-29 | 2.4 | HIV-1 Reverse Transcriptase in complex with a 2,6-difluorophenyl DAPY analog |
| 2RF2 | 2008-01-01 | 2.4 | HIV reverse transcriptase in complex with inhibitor 7e (NNRTI) |
| 1VIJ | 1999-01-13 | 2.4 | HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR HOE/BAY 793 HEXAGONAL FORM |
| 5VQX | 2017-08-23 | 2.4 | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with 2-chloro-N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacetamide (JLJ686), a Non-nucleoside Inhibitor |
| 6O9E | 2019-10-23 | 2.4 | Structure of HIV-1 Reverse Transcriptase in complex with DNA and INDOPY-1 |
| 1HRH | 1992-01-15 | 2.4 | CRYSTAL STRUCTURE OF THE RIBONUCLEASE H DOMAIN OF HIV-1 REVERSE TRANSCRIPTASE |
| 3MEE | 2010-05-12 | 2.4 | HIV-1 Reverse Transcriptase in Complex with TMC278 |
| 6CQL | 2018-06-06 | 2.4 | Crystal structure of F24 TCR -DR11-RQ13 peptide complex |
| 6CPO | 2018-06-06 | 2.4 | Crystal structure of DR15 presenting the RQ13 peptide |
| 3DS5 | 2008-09-02 | 2.4 | HIV-1 capsid C-terminal domain mutant (N183A) |
| 4G8G | 2013-03-20 | 2.4 | Crystal Structure of C12C TCR-HA B2705-KK10 |
| 1VIK | 1998-12-09 | 2.4 | HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR HOE/BAY 793 ORTHORHOMBIC FORM |
| 6AXT | 2018-09-12 | 2.4 | Structure of the T58S/T107I/P122A mutant of the HIV-1 capsid protein |
| 6AYA | 2018-09-12 | 2.4 | Structure of the native full-length HIV-1 capsid protein in complex with Nup153 peptide |
| 6AXS | 2018-09-12 | 2.4 | Structure of the V11I/T58A/P122A mutant of the HIV-1 capsid protein |
| 7HVP | 1993-07-15 | 2.4 | X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN A SYNTHETIC PROTEASE OF HUMAN IMMUNODEFICIENCY VIRUS 1 AND A SUBSTRATE-BASED HYDROXYETHYLAMINE INHIBITOR |
| 5OI5 | 2018-03-07 | 2.4 | Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 |
| 1S1T | 2004-06-29 | 2.4 | Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with UC-781 |
| 6AXW | 2018-09-12 | 2.4 | Structure of the I124A mutant of the HIV-1 capsid protein |
| 2X2C | 2010-03-23 | 2.41 | acetyl-CypA:cyclosporine complex |
| 6B2G | 2018-09-26 | 2.41 | P38A mutant of HIV-1 capsid protein |
| 3K0R | 2009-12-08 | 2.42 | Cryogenic structure of CypA mutant Arg55Lys |
| 2BE2 | 2005-12-06 | 2.43 | Crystal structure of HIV-1 reverse transcriptase (RT) in complex with R221239 |
| 5J2M | 2016-08-03 | 2.43 | HIV-1 reverse transcriptase in complex with DNA and EFdA-triphosphate, a translocation-defective RT inhibitor |
| 6IK9 | 2019-01-30 | 2.43 | HIV-1 reverse transcriptase with Q151M/G112S/D113A/Y115F/F116Y/F160L/I159L:DNA:dGTP ternary complex |
| 4XFX | 2015-06-10 | 2.43 | Structure of the native full-length HIV-1 capsid protein |
| 4EJL | 2013-05-01 | 2.44 | Apo HIV Protease (PR) dimer in closed form with fragment 1F1-N in the outside/top of flap |
| 6BSG | 2018-01-03 | 2.44 | Structure of HIV-1 RT complexed with RNA/DNA hybrid in an RNA hydrolysis-off mode |
| 4COE | 2014-12-10 | 2.45 | Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol |
| 6CPL | 2018-06-06 | 2.45 | Crystal structure of DR11 presenting the gag293 epitope |
| 1M0B | 2004-01-13 | 2.45 | HIV-1 protease in complex with an ethyleneamine inhibitor |
| 4QLH | 2014-08-06 | 2.45 | Crystal structure of drug resistant V82S/V1082S HIV-1 Protease |
| 4DMN | 2012-03-21 | 2.45 | HIV-1 Integrase Catalytical Core Domain |
| 5XN1 | 2018-02-07 | 2.45 | HIV-1 reverse transcriptase Q151M:DNA:entecavir-triphosphate ternary complex |
| 1SJE | 2004-08-17 | 2.45 | HLA-DR1 complexed with a 16 residue HIV capsid peptide bound in a hairpin conformation |
| 4WE1 | 2014-12-03 | 2.49 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ600) |
| 2YNI | 2013-01-09 | 2.49 | HIV-1 Reverse Transcriptase in complex with inhibitor GSK952 |
| 1BIU | 1998-08-19 | 2.5 | HIV-1 INTEGRASE CORE DOMAIN COMPLEXED WITH MG++ |
| 6AY9 | 2018-09-12 | 2.5 | Structure of the native full-length HIV-1 capsid protein in complex with CPSF6 peptide |
| 5VQW | 2017-08-23 | 2.5 | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)acrylamide (JLJ685), a Non-nucleoside Inhibitor |
| 5TXL | 2017-04-05 | 2.5 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP |
| 1SH9 | 2004-10-05 | 2.5 | Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease |
| 1C1B | 2000-07-21 | 2.5 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GCA-186 |
| 3MED | 2010-05-12 | 2.5 | HIV-1 K103N Reverse Transcriptase in Complex with TMC125 |
| 1A8G | 1998-07-15 | 2.5 | HIV-1 PROTEASE IN COMPLEX WITH SDZ283-910 |
| 2Q64 | 2008-02-26 | 2.5 | HIV-1 PR mutant in complex with nelfinavir |
| 5IM7 | 2016-10-05 | 2.5 | Crystal structure of HLA-B5801, a protective HLA allele for HIV-1 infection |
| 2IAJ | 2006-12-19 | 2.5 | Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with ATP |
| 6CQN | 2018-06-06 | 2.5 | Crystal structure of F5 TCR -DR11-RQ13 peptide complex |
| 5VQS | 2017-08-23 | 2.5 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)acrylamide (JLJ685), a Non-nucleoside Inhibitor |
| 1HPO | 1997-04-21 | 2.5 | HIV-1 PROTEASE TRIPLE MUTANT/U103265 COMPLEX |
| 6X4B | 2020-07-22 | 2.5 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-5-fluoro-8-methyl-2-naphthonitrile (JLJ655), a Non-nucleoside Inhibitor |
| 2HND | 2006-09-05 | 2.5 | Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with Nevirapine |
| 3P05 | 2011-01-12 | 2.5 | X-ray structure of pentameric HIV-1 CA |
| 6AMO | 2018-08-15 | 2.5 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 7.0 |
| 6B2I | 2018-09-26 | 2.5 | E45A mutant of the HIV-1 capsid protein |
| 6U5G | 2020-01-29 | 2.5 | MicroED structure of a FIB-milled CypA Crystal |
| 1MTB | 2003-01-07 | 2.5 | Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy |
| 4I7F | 2013-02-20 | 2.5 | HIV-1 Reverse Transcriptase in complex with a phosphonate analog of nevirapine |
| 1EP4 | 2000-09-27 | 2.5 | Crystal structure of HIV-1 reverse transcriptase in complex with S-1153 |
| 3N3I | 2010-06-09 | 2.5 | Crystal Structure of G48V/C95F tethered HIV-1 Protease/Saquinavir complex |
| 1AAQ | 1994-06-22 | 2.5 | HYDROXYETHYLENE ISOSTERE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE: STRUCTURE-ACTIVITY ANALYSIS USING ENZYME KINETICS, X-RAY CRYSTALLOGRAPHY, AND INFECTED T-CELL ASSAYS |
| 1JLA | 2001-10-03 | 2.5 | CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-651 |
| 3DLE | 2008-08-12 | 2.5 | Crystal structure of hiv-1 reverse transcriptase in complex with GF128590. |
| 1C1C | 2000-07-21 | 2.5 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-6123 |
| 1JKH | 2001-10-03 | 2.5 | CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ) |
| 3AID | 1997-09-17 | 2.5 | A NEW CLASS OF HIV-1 PROTEASE INHIBITOR: THE CRYSTALLOGRAPHIC STRUCTURE, INHIBITION AND CHEMICAL SYNTHESIS OF AN AMINIMIDE PEPTIDE ISOSTERE |
| 6AVM | 2018-08-15 | 2.5 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 9.5 WITH CROSS-LINKING TO SECOND BASE TEMPLATE OVERHANG |
| 5TSV | 2017-11-08 | 2.5 | HIV-1 CA hexamer with NUP153 peptide - R3 crystal form |
| 1D4S | 1999-10-12 | 2.5 | HIV-1 PROTEASE V82F/I84V DOUBLE MUTANT/TIPRANAVIR COMPLEX |
| 4IG0 | 2013-02-06 | 2.5 | HIV-1 reverse transcriptase with bound fragment at the 507 site |
| 1BI4 | 1998-11-04 | 2.5 | CATALYTIC DOMAIN OF HIV-1 INTEGRASE |
| 3GGA | 2009-05-26 | 2.5 | HIV Protease inhibitors with pseudo-symmetric cores |
| 2HNY | 2006-09-05 | 2.5 | Crystal Structure of E138K Mutant HIV-1 Reverse Transcriptase in Complex with Nevirapine |
| 6JCG | 2019-07-17 | 2.5 | Room temperature structure of HIV-1 Integrase catalytic core domain by serial femtosecond crystallography. |
| 3ISN | 2010-03-16 | 2.5 | Crystal structure of HIV-1 RT bound to A 6-vinylpyrimidine inhibitor |
| 8HVP | 1993-10-31 | 2.5 | STRUCTURE AT 2.5-ANGSTROMS RESOLUTION OF CHEMICALLY SYNTHESIZED HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE COMPLEXED WITH A HYDROXYETHYLENE*-BASED INHIBITOR |
| 1HHJ | 1993-10-31 | 2.5 | THE ANTIGENIC IDENTITY OF PEPTIDE(SLASH)MHC COMPLEXES: A COMPARISON OF THE CONFORMATION OF FIVE PEPTIDES PRESENTED BY HLA-A2 |
| 1BDQ | 1998-08-12 | 2.5 | HIV-1 (2:31-37, 47, 82) PROTEASE COMPLEXED WITH INHIBITOR SB203386 |
| 2AZ9 | 2006-02-28 | 2.5 | HIV-1 Protease NL4-3 1X mutant |
| 1FK9 | 2000-11-03 | 2.5 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ) |
| 2BPZ | 1999-02-23 | 2.5 | HIV-1 protease-inhibitor complex |
| 3LAL | 2010-02-23 | 2.51 | Crystal structure of HIV-1 reverse transcriptase in complex with N1-ethyl pyrimidinedione non-nucleoside inhibitor |
| 6KDJ | 2020-03-04 | 2.51 | HIV-1 reverse transcriptase with Q151M/Y115F/F116Y:DNA:lamivudine 5'-triphosphate ternary complex |
| 3TAM | 2011-10-26 | 2.51 | Crystal structure of HIV-1 reverse transcriptase (K103N mutant) in complex with inhibitor M06 |
| 4PQU | 2014-06-18 | 2.51 | Crystal structure of HIV-1 Reverse Transcriptase in complex with RNA/DNA and dATP |
| 1C0U | 2000-07-19 | 2.52 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+50.0934 |
| 5J2P | 2016-08-03 | 2.53 | HIV-1 reverse transcriptase in complex with DNA that has incorporated EFdA-MP at the P-(post-translocation) site and a second EFdA-MP at the N-(pre-translocation) site |
| 6OR7 | 2019-07-24 | 2.53 | Structure of HIV-1 Reverse Transcriptase (RT) in complex with DNA AND (-)FTC-TP |
| 6X4A | 2020-07-22 | 2.54 | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with 5-chloro-7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-8-methyl-2-naphthonitrile (JLJ651), a Non-nucleoside Inhibitor |
| 2OPP | 2007-05-22 | 2.55 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with GW420867X. |
| 1AWS | 1998-03-18 | 2.55 | SECYPA COMPLEXED WITH HAGPIA (PSEUDO-SYMMETRIC MONOMER) |
| 3LAN | 2010-02-23 | 2.55 | Crystal structure of HIV-1 reverse transcriptase in complex with N1-butyl pyrimidinedione non-nucleoside inhibitor |
| 6P1X | 2019-07-24 | 2.55 | Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and L-ddCTP |
| 2R05 | 2007-12-18 | 2.55 | Crystal Structure of ALIX/AIP1 in complex with the HIV-1 YPLASL Late Domain |
| 1RT1 | 1997-04-21 | 2.55 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH MKC-442 |
| 3IS9 | 2010-04-07 | 2.55 | Crystal structure of the HIV-1 reverse transcriptase (RT) in complex with the alkenyldiarylmethane (ADAM) Non-nucleoside RT Inhibitor dimethyl 3,3'-(6-methoxy-6-oxohex-1-ene-1,1-diyl)bis(5-cyano-6-methoxybenzoate). |
| 1RT2 | 1997-04-21 | 2.55 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH TNK-651 |
| 5VQR | 2017-08-23 | 2.55 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacrylamide (JLJ684), a Non-nucleoside Inhibitor |
| 1AWT | 1998-03-18 | 2.55 | SECYPA COMPLEXED WITH HAGPIA |
| 5TXO | 2017-04-05 | 2.55 | STRUCTURE OF Q151M complex (A62V, V75I, F77L, F116Y, Q151M) mutant HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP |
| 1ZKF | 2006-04-11 | 2.55 | Cyrstal Structure of Human Cyclophilin-A in Complex with suc-AGPF-pNA |
| 5TXN | 2017-04-05 | 2.55 | STRUCTURE OF Q151M MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP |
| 5VQQ | 2017-08-23 | 2.55 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-2-fluoro-N-methylacetamide (JLJ683), a Non-nucleoside Inhibitor |
| 6KDK | 2020-03-04 | 2.56 | HIV-1 reverse transcriptase with Q151M/Y115F/F116Y:DNA:dCTP ternary complex |
| 5VQT | 2017-08-23 | 2.56 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 2-chloro-N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacetamide (JLJ686), a Non-nucleoside Inhibitor |
| 6UJZ | 2019-12-25 | 2.56 | HIV-1 wild-type reverse transcriptase-DNA complex with (+)-FTC-TP |
| 6KDO | 2020-03-04 | 2.57 | HIV-1 reverse transcriptase with Q151M/Y115F/F116Y/M184V/F160M:DNA:lamivudine 5'-triphosphate ternary complex |
| 5VQV | 2017-08-23 | 2.58 | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacrylamide (JLJ684), a Non-nucleoside Inhibitor |
| 4NCG | 2014-02-12 | 2.58 | Discovery of Doravirine, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses |
| 6ANQ | 2018-08-15 | 2.59 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 8.5 |
| 6UJY | 2019-12-25 | 2.59 | HIV-1 wild-type reverse transcriptase-DNA complex with (-)-3TC-TP |
| 6B2H | 2018-09-26 | 2.6 | P38A/T216I mutant of the HIV-1 capsid protein |
| 3T19 | 2011-10-26 | 2.6 | Crystal structure of HIV-1 reverse transcriptase (wild type) in complex with inhibitor M05 |
| 6AVT | 2018-08-15 | 2.6 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 9.5 WITH CROSS-LINKING TO FIRST BASE TEMPLATE OVERHANG |
| 3QO9 | 2011-05-04 | 2.6 | Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with TSAO-T, a non-nucleoside RT inhibitor (NNRTI) |
| 5XN0 | 2018-02-07 | 2.6 | HIV-1 reverse transcriptase Q151M:DNA binary complex |
| 1REV | 1996-10-14 | 2.6 | HIV-1 REVERSE TRANSCRIPTASE |
| 1JLF | 2001-10-03 | 2.6 | CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE |
| 4WYM | 2014-12-17 | 2.6 | Structural basis of HIV-1 capsid recognition by CPSF6 |
| 4ZHR | 2015-11-11 | 2.6 | Structure of HIV-1 RT Q151M mutant |
| 1BAJ | 1998-10-14 | 2.6 | HIV-1 CAPSID PROTEIN C-TERMINAL FRAGMENT PLUS GAG P2 DOMAIN |
| 1S9E | 2004-05-11 | 2.6 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R129385 |
| 6AN8 | 2018-08-15 | 2.6 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 8.0 |
| 5C24 | 2015-07-29 | 2.6 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 7-((4-((4-cyanophenyl)amino)-1,3,5-triazin-2-yl)amino)-6,8-dimethylindolizine-2-carbonitrile (JLJ605), a non-nucleoside inhibitor |
| 3FFI | 2009-12-15 | 2.6 | HIV-1 RT with pyridone non-nucleoside inhibitor |
| 1A43 | 1999-02-09 | 2.6 | STRUCTURE OF THE HIV-1 CAPSID PROTEIN DIMERIZATION DOMAIN AT 2.6A RESOLUTION |
| 5VQU | 2017-08-23 | 2.6 | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-2-fluoro-N-methylacetamide (JLJ683), a Non-nucleoside Inhibitor |
| 1S1V | 2004-06-29 | 2.6 | Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with TNK-651 |
| 1TKT | 2004-12-07 | 2.6 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW426318 |
| 1FB7 | 2000-12-13 | 2.6 | CRYSTAL STRUCTURE OF AN IN VIVO HIV-1 PROTEASE MUTANT IN COMPLEX WITH SAQUINAVIR: INSIGHTS INTO THE MECHANISMS OF DRUG RESISTANCE |
| 3DRP | 2008-10-14 | 2.6 | HIV reverse transcriptase in complex with inhibitor R8e |
| 2ITG | 1997-03-12 | 2.6 | CATALYTIC DOMAIN OF HIV-1 INTEGRASE: ORDERED ACTIVE SITE IN THE F185H CONSTRUCT |
| 6X4E | 2020-07-22 | 2.6 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with methyl 2-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)acetate (JLJ681), a Non-nucleoside Inhibitor |
| 6AXX | 2018-09-12 | 2.6 | Structure of the T58A/I124A mutant of the HIV-1 capsid protein |
| 6IKA | 2019-01-30 | 2.6 | HIV-1 reverse transcriptase with Q151M/G112S/D113A/Y115F/F116Y/F160L/I159L:DNA:entecavir-triphosphate ternary complex |
| 1JLG | 2001-10-03 | 2.6 | CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH UC-781 |
| 2R02 | 2007-12-18 | 2.6 | Crystal Structure of ALIX/AIP1 in complex with the HIV-1 YPLTSL Late Domain |
| 6ASW | 2018-08-15 | 2.61 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 9.0 |
| 1LWC | 2002-10-30 | 2.62 | CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE |
| 6GL1 | 2018-08-08 | 2.62 | HLA-E*01:03 in complex with the HIV epitope, RL9HIV |
| 4RW6 | 2015-04-29 | 2.63 | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) variant in complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor |
| 6UIR | 2019-12-25 | 2.64 | HIV-1 M184V reverse transcriptase-DNA complex with (-)-FTC-TP |
| 5EU7 | 2016-09-28 | 2.64 | Crystal structure of HIV-1 integrase catalytic core in complex with Fab |
| 3KLI | 2010-09-22 | 2.65 | Crystal structure of unliganded AZT-resistant HIV-1 Reverse Transcriptase |
| 3DI6 | 2008-08-19 | 2.65 | HIV-1 RT with pyridazinone non-nucleoside inhibitor |
| 6BSH | 2018-01-03 | 2.65 | Structure of HIV-1 RT complexed with RNA/DNA hybrid in the RNA hydrolysis mode |
| 2B6A | 2005-11-01 | 2.65 | Crystal structure of HIV-1 reverse transcriptase (RT) in complex with THR-50 |
| 6X4D | 2020-07-22 | 2.65 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(cyclopropylmethyl)-7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-8-methyl-2-naphthonitrile (JLJ678), a Non-nucleoside Inhibitor |
| 4DGC | 2012-02-08 | 2.65 | TRIMCyp cyclophilin domain from Macaca mulatta: cyclosporin A complex |
| 4GW6 | 2013-05-01 | 2.65 | HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor |
| 1KLM | 1998-03-18 | 2.65 | HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH BHAP U-90152 |
| 6OUN | 2019-07-24 | 2.66 | Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (-)3TC-TP |
| 3M8P | 2010-05-19 | 2.67 | HIV-1 RT with NNRTI TMC-125 |
| 5KGX | 2016-10-19 | 2.67 | HIV1 catalytic core domain in complex with an inhibitor (2~{S})-2-[3-(3,4-dihydro-2~{H}-chromen-6-yl)-1-methyl-indol-2-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid |
| 4RW4 | 2015-04-29 | 2.67 | Crystal Structure of HIV-1 Reverse Transcriptase (K103N,Y181C) variant in complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor |
| 4KSE | 2014-08-13 | 2.68 | Crystal structure of a HIV p51 (219-230) deletion mutant |
| 4LSL | 2013-12-25 | 2.69 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-(4-chloro-2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ476), a non-nucleoside inhibitor |
| 6BHT | 2018-08-01 | 2.69 | HIV-1 CA hexamer in complex with IP6, orthorhombic crystal form |
| 5TXM | 2017-04-05 | 2.7 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DDATP |
| 5TUQ | 2017-06-28 | 2.7 | Crystal Structure of a 6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione Inhibitor in Complex with HIV Reverse Transcriptase |
| 3QLH | 2011-12-21 | 2.7 | HIV-1 Reverse Transcriptase in Complex with Manicol at the RNase H Active Site and TMC278 (Rilpivirine) at the NNRTI Binding Pocket |
| 2FDE | 2006-02-21 | 2.7 | Wild type HIV protease bound with GW0385 |
| 3GGX | 2009-05-26 | 2.7 | HIV Protease, pseudo-symmetric inhibitors |
| 3C6U | 2008-04-22 | 2.7 | Crystal Structure of HIV Reverse Transcriptase in complex with inhibitor 22 |
| 6UJX | 2019-12-25 | 2.7 | HIV-1 wild-type reverse transcriptase-DNA complex with (-)-FTC-TP |
| 3I0S | 2009-08-25 | 2.7 | crystal structure of HIV reverse transcriptase in complex with inhibitor 7 |
| 5TXP | 2017-04-05 | 2.7 | STRUCTURE OF Q151M complex (A62V, V75I, F77L, F116Y, Q151M) mutant HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DDATP |
| 1S1W | 2004-06-29 | 2.7 | Crystal structure of V106A mutant HIV-1 reverse transcriptase in complex with UC-781 |
| 3V6D | 2012-01-18 | 2.7 | Crystal structure of HIV-1 reverse transcriptase (RT) cross-linked with AZT-terminated DNA |
| 4I2Q | 2013-01-16 | 2.7 | Crystal structure of K103N/Y181C mutant of HIV-1 reverse transcriptase in complex with rilpivirine (TMC278) analogue |
| 3PHV | 1992-01-15 | 2.7 | X-RAY ANALYSIS OF HIV-1 PROTEINASE AT 2.7 ANGSTROMS RESOLUTION CONFIRMS STRUCTURAL HOMOLOGY AMONG RETROVIRAL ENZYMES |
| 3H4E | 2009-06-23 | 2.7 | X-ray Structure of Hexameric HIV-1 CA |
| 5TER | 2017-01-11 | 2.7 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-chloro-7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-8-methyl-2-naphthonitrile (JLJ651), a Non-nucleoside Inhibitor |
| 1HQE | 2001-05-30 | 2.7 | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 |
| 1DLO | 1996-08-01 | 2.7 | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 |
| 3C6T | 2008-04-22 | 2.7 | Crystal Structure of HIV Reverse Transcriptase in complex with inhibitor 14 |
| 3KK1 | 2010-03-23 | 2.7 | HIV-1 reverse transcriptase-DNA complex with nuceotide inhibitor GS-9148-diphosphate bound in nucleotide site |
| 1HHP | 1992-10-15 | 2.7 | THE THREE-DIMENSIONAL STRUCTURE OF THE ASPARTYL PROTEASE FROM THE HIV-1 ISOLATE BRU |
| 3M8Q | 2010-05-19 | 2.7 | HIV-1 RT with AMINOPYRIMIDINE NNRTI |
| 1C0T | 2000-07-19 | 2.7 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+21.1326 |
| 3DS3 | 2008-09-02 | 2.7 | HIV-1 capsid C-terminal domain mutant (Y169A) in complex with an inhibitor of particle assembly (CAI) |
| 6AN2 | 2018-08-15 | 2.7 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 7.5 |
| 1HQU | 2001-05-30 | 2.7 | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 |
| 4XFZ | 2015-06-10 | 2.7 | Structure of the native full-length HIV-1 capsid protein in complex with PF-3450074 (PF74) |
| 4O4G | 2014-11-05 | 2.71 | Crystal Structure of HIV-1 Reverse Transcriptase in complex with 4-((4-(mesitylamino)-1,3,5-triazin-2-yl)amino)benzonitrile (JLJ527), a non-nucleoside inhibitor |
| 6X4F | 2020-07-22 | 2.72 | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with methyl 2-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)acetate (JLJ681), a Non-nucleoside Inhibitor |
| 1EET | 2001-02-07 | 2.73 | HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH THE INHIBITOR MSC204 |
| 6R6Q | 2020-05-06 | 2.73 | HIV capsid hexamer with IP5 ligand |
| 6DTW | 2019-07-31 | 2.74 | HIV-1 Reverse Transcriptase Y181C Mutant in complex with JLJ 578 |
| 6X49 | 2020-07-22 | 2.74 | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with 7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ649), a Non-nucleoside Inhibitor |
| 6P1I | 2019-07-24 | 2.74 | Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and dCTP |
| 5HRO | 2016-06-01 | 2.75 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A DNA aptamer and an Alpha-carboxy nucleoside phosphonate inhibitor (alpha-CNP) |
| 6CQJ | 2018-06-06 | 2.75 | Crystal structure of DR1 presenting the RQ13 peptide |
| 6UIS | 2019-12-25 | 2.75 | HIV-1 M184V reverse transcriptase-DNA complex with dCTP |
| 5NMG | 2017-11-15 | 2.75 | 868 TCR in complex with HLA A02 presenting SLYFNTIAVL |
| 5O2U | 2017-06-21 | 2.76 | Llama VHH in complex with p24 |
| 6UK0 | 2019-12-25 | 2.76 | HIV-1 M184V reverse transcriptase-DNA complex |
| 3LAM | 2010-02-23 | 2.76 | Crystal structure of HIV-1 reverse transcriptase in complex with N1-propyl pyrimidinedione non-nucleoside inhibitor |
| 6X47 | 2020-07-22 | 2.77 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ649), a Non-nucleoside Inhibitor |
| 6AXV | 2018-09-12 | 2.77 | Structure of the T58S/T107I/P122A mutant of the HIV-1 capsid protein in complex with PF-3450074 (PF74) |
| 6AXY | 2018-09-12 | 2.78 | Structure of the V11I/T58A/I124A mutant of the HIV-1 capsid protein |
| 4DQG | 2012-03-07 | 2.79 | Crystal Structure of apo(G16C/L38C) HIV-1 Protease |
| 5J2Q | 2016-08-03 | 2.79 | HIV-1 reverse transcriptase in complex with DNA that has incorporated a mismatched EFdA-MP at the N-(pre-translocation) site |
| 3LP0 | 2010-06-09 | 2.79 | HIV-1 reverse transcriptase with inhibitor |
| 5XOT | 2017-06-14 | 2.79 | Crystal structure of pHLA-B35 in complex with TU55 T cell receptor |
| 1DTQ | 2000-03-20 | 2.8 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-1 (PETT131A94) |
| 3HVP | 1989-10-15 | 2.8 | CONSERVED FOLDING IN RETROVIRAL PROTEASES. CRYSTAL STRUCTURE OF A SYNTHETIC HIV-1 PROTEASE |
| 2HMI | 1998-10-14 | 2.8 | HIV-1 REVERSE TRANSCRIPTASE/FRAGMENT OF FAB 28/DNA COMPLEX |
| 2VG5 | 2007-12-11 | 2.8 | Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors |
| 3ITH | 2010-03-16 | 2.8 | Crystal structure of the HIV-1 reverse transcriptase bound to a 6-vinylpyrimidine inhibitor |
| 1HTE | 1994-07-31 | 2.8 | X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE |
| 1EX4 | 2000-06-07 | 2.8 | HIV-1 INTEGRASE CATALYTIC CORE AND C-TERMINAL DOMAIN |
| 2BPX | 1999-02-23 | 2.8 | HIV-1 protease-inhibitor complex |
| 3S85 | 2012-04-11 | 2.8 | Discovery of New HIV Protease Inhibitors with Potential for Convenient Dosing and Reduced Side Effects: A-790742 and A-792611. |
| 3LP3 | 2010-06-09 | 2.8 | p15 HIV RNaseH domain with inhibitor MK3 |
| 3IG1 | 2010-01-26 | 2.8 | HIV-1 Reverse Transcriptase with the Inhibitor beta-Thujaplicinol Bound at the RNase H Active Site |
| 3LP2 | 2010-06-09 | 2.8 | HIV-1 reverse transcriptase with inhibitor |
| 4U0B | 2014-11-12 | 2.8 | Hexamer HIV-1 CA in complex with CPSF6 peptide, P212121 crystal form |
| 1LWF | 2002-10-30 | 2.8 | CRYSTAL STRUCTURE OF A MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMQ+M184V: M41L/D67N/K70R/M184V/T215Y) IN COMPLEX WITH NEVIRAPINE |
| 1LW0 | 2002-10-30 | 2.8 | CRYSTAL STRUCTURE OF T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE |
| 1RDH | 1994-05-31 | 2.8 | CRYSTALLOGRAPHIC ANALYSES OF AN ACTIVE HIV-1 RIBONUCLEASE H DOMAIN SHOW STRUCTURAL FEATURES THAT DISTINGUISH IT FROM THE INACTIVE FORM |
| 1S1X | 2004-06-29 | 2.8 | Crystal structure of V108I mutant HIV-1 reverse transcriptase in complex with nevirapine |
| 3V4I | 2012-01-18 | 2.8 | Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and AZTTP |
| 6PUY | 2020-02-12 | 2.8 | Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and INSTI XZ426 (compound 4d) |
| 2WON | 2010-08-11 | 2.8 | Crystal Structure of UK-453061 bound to HIV-1 Reverse Transcriptase (wild-type). |
| 1TV6 | 2004-07-20 | 2.8 | HIV-1 Reverse Transcriptase Complexed with CP-94,707 |
| 1TL3 | 2004-12-07 | 2.8 | Crystal structure of hiv-1 reverse transcriptase in complex with gw450557 |
| 4XFY | 2015-06-10 | 2.8 | Structure of the native full-length dehydrated HIV-1 capsid protein |
| 3D3T | 2008-07-08 | 2.8 | Crystal Structure of HIV-1 CRF01_AE in complex with the substrate p1-p6 |
| 1RT6 | 1999-07-29 | 2.8 | HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC38 |
| 3IRX | 2010-04-07 | 2.8 | Crystal Structure of HIV-1 reverse transcriptase (RT) in complex with the Non-nucleoside RT Inhibitor (E)-S-Methyl 5-(1-(3,7-Dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-5-(5-methyl-1,3,4-oxadiazol-2-yl)pent-1-enyl)-2-methoxy-3-methylbenzothioate. |
| 1M63 | 2002-09-25 | 2.8 | Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes |
| 1R0A | 2004-08-03 | 2.8 | Crystal structure of HIV-1 reverse transcriptase covalently tethered to DNA template-primer solved to 2.8 angstroms |
| 6CQQ | 2018-06-06 | 2.8 | Crystal structure of F24 TCR -DR15-RQ13 peptide complex |
| 1JLE | 2001-10-03 | 2.8 | CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE |
| 1BDR | 1998-10-14 | 2.8 | HIV-1 (2: 31, 33-37) PROTEASE COMPLEXED WITH INHIBITOR SB203386 |
| 1S9G | 2004-05-11 | 2.8 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R120394. |
| 9HVP | 1992-04-15 | 2.8 | Design, activity and 2.8 Angstroms crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease |
| 2OPQ | 2007-05-22 | 2.8 | Crystal Structure of L100I Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X. |
| 2BPW | 1999-02-23 | 2.8 | HIV-1 protease-inhibitor complex |
| 1HNI | 1995-06-03 | 2.8 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN A COMPLEX WITH THE NONNUCLEOSIDE INHIBITOR ALPHA-APA R 95845 AT 2.8 ANGSTROMS RESOLUTION |
| 1IKX | 2001-06-06 | 2.8 | K103N Mutant HIV-1 Reverse Transcriptase in Complex with the Inhibitor PNU142721 |
| 6PUZ | 2020-02-12 | 2.8 | Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and INSTI XZ446 (compound 4f) |
| 1BDL | 1998-08-12 | 2.8 | HIV-1 (2:31-37) PROTEASE COMPLEXED WITH INHIBITOR SB203386 |
| 3MEG | 2010-05-12 | 2.8 | HIV-1 K103N Reverse Transcriptase in Complex with TMC278 |
| 6BHJ | 2018-10-31 | 2.81 | Structure of HIV-1 Reverse Transcriptase Bound to a 38-mer Hairpin Template-Primer RNA-DNA Aptamer |
| 1LWE | 2002-10-30 | 2.81 | CRYSTAL STRUCTURE OF M41L/T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMN) IN COMPLEX WITH NEVIRAPINE |
| 1TKZ | 2004-12-07 | 2.81 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW429576 |
| 6UIT | 2019-12-25 | 2.81 | HIV-1 wild-type reverse transcriptase-DNA complex with dCTP |
| 2VG7 | 2007-12-11 | 2.82 | Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors |
| 5C25 | 2015-07-29 | 2.84 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 6-((4-((4-cyanophenyl)amino)-1,3,5-triazin-2-yl)amino)-5,7-dimethyl-2-naphthonitrile (JLJ639), a Non-nucleoside Inhibitor |
| 3V81 | 2012-01-18 | 2.85 | Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and the nonnucleoside inhibitor nevirapine |
| 5TW3 | 2017-03-15 | 2.85 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)-4-fluorophenoxy)-7-fluoro-2-naphthonitrile (JLJ636), a Non-nucleoside Inhibitor |
| 4H4M | 2012-12-05 | 2.85 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor |
| 1QE1 | 1999-08-30 | 2.85 | CRYSTAL STRUCTURE OF 3TC-RESISTANT M184I MUTANT OF HIV-1 REVERSE TRANSCRIPTASE |
| 1TKX | 2004-12-07 | 2.85 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745 |
| 6OTZ | 2019-07-24 | 2.86 | Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (+)FTC-TP |
| 6X4C | 2020-07-22 | 2.86 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)-4-fluorophenoxy)-5,8-dimethyl-2-naphthonitrile (JLJ658), a Non-nucleoside Inhibitor |
| 4MFB | 2013-11-06 | 2.88 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)indolizine-2-carbonitrile (JLJ555), a non-nucleoside inhibitor |
| 5V5M | 2017-06-14 | 2.88 | Crystal structure of HLA-B*5701 complex with HIV-1 gag derived peptide TW10 |
| 5INC | 2016-10-05 | 2.88 | Crystal structure of HLA-B5801, a protective HLA allele for HIV-1 infection |
| 4RW8 | 2015-04-29 | 2.88 | Crystal Structure of HIV-1 Reverse Transcriptase in complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ532), a non-nucleoside inhibitor' |
| 5NMF | 2017-11-15 | 2.89 | 868 TCR in complex with HLA A02 presenting SLYNTIATL |
| 4R5P | 2015-03-11 | 2.89 | Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and a nucleoside triphosphate mimic alpha-carboxy nucleoside phosphonate inhibitor |
| 3DRR | 2008-10-14 | 2.89 | HIV reverse transcriptase Y181C mutant in complex with inhibitor R8e |
| 6BSJ | 2018-01-03 | 2.89 | Structure of HIV-1 RT complexed with an RNA/DNA hybrid sequence non-preferred for RNA hydrolysis |
| 4KKO | 2013-08-14 | 2.89 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 4-((4-methoxy-6-(2-morpholinoethoxy)-1,3,5-triazin-2-yl)amino)-2-((3-methylbut-2-en-1-yl)oxy)benzonitrile (JLJ513), a non-nucleoside inhibitor |
| 4O44 | 2014-05-21 | 2.89 | Crystal Structure of HIV-1 Reverse Transcriptase in complex with 4-((4-(mesitylamino)-6-(3-morpholinopropoxy)-1,3,5-triazin-2-yl)amino)benzonitrile (JLJ529), a non-nucleoside inhibitor |
| 1TL1 | 2004-12-07 | 2.9 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW451211 |
| 3KK3 | 2010-03-23 | 2.9 | HIV-1 reverse transcriptase-DNA complex with GS-9148 terminated primer |
| 2YNH | 2013-01-09 | 2.9 | HIV-1 Reverse Transcriptase in complex with inhibitor GSK500 |
| 1RT4 | 1999-07-29 | 2.9 | HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC781 |
| 3DOK | 2008-08-12 | 2.9 | Crystal structure of K103N mutant HIV-1 reverse transcriptase in complex with GW678248. |
| 6PUW | 2020-02-12 | 2.9 | Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and Bictegravir (BIC) |
| 4PUO | 2014-06-18 | 2.9 | Crystal structure of HIV-1 reverse transcriptase in complex with RNA/DNA and Nevirapine |
| 5HP1 | 2016-06-01 | 2.9 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A DNA aptamer and FOSCARNET, a Pyrophosphate analog |
| 1FKO | 2000-11-03 | 2.9 | CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ) |
| 2OPR | 2007-05-22 | 2.9 | Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X. |
| 1RT5 | 1999-07-29 | 2.9 | HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC10 |
| 1FKP | 2000-11-03 | 2.9 | CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE |
| 5J2N | 2016-08-03 | 2.9 | HIV-1 reverse transcriptase in complex with DNA that has incorporated EFdA-MP at the P-(post-translocation) site and dTMP at the N-(pre-translocation) site |
| 1S6P | 2004-05-11 | 2.9 | CRYSTAL STRUCTURE OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R100943 |
| 6PUT | 2020-02-12 | 2.9 | Structure of HIV cleaved synaptic complex (CSC) intasome bound with calcium |
| 1KJ4 | 2002-03-06 | 2.9 | SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES |
| 6OE3 | 2019-05-15 | 2.9 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-7-fluoro-2-naphthonitrile (JLJ635), a Non-nucleoside Inhibitor |
| 3KLH | 2010-09-22 | 2.9 | Crystal structure of AZT-Resistant HIV-1 Reverse Transcriptase crosslinked to post-translocation AZTMP-Terminated DNA (COMPLEX P) |
| 5J1E | 2016-06-15 | 2.9 | Crystal Structure of a Hydroxypyridone Carboxylic Acid Active-Site RNase H Inhibitor in Complex with HIV Reverse Transcriptase |
| 2ZE2 | 2008-02-12 | 2.9 | Crystal structure of L100I/K103N mutant HIV-1 reverse transcriptase (RT) in complex with TMC278 (rilpivirine), a non-nucleoside RT inhibitor |
| 3KK2 | 2010-03-23 | 2.9 | HIV-1 reverse transcriptase-DNA complex with dATP bound in the nucleotide binding site |
| 2YKM | 2011-08-17 | 2.9 | Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with a Difluoromethylbenzoxazole (DFMB) Pyrimidine Thioether derivative, a non-nucleoside RT inhibitor (NNRTI) |
| 2B5J | 2005-12-06 | 2.9 | Crystal structure of HIV-1 reverse transcriptase (RT) in complex with JANSSEN-R165481 |
| 4H4O | 2012-12-05 | 2.9 | Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with (E)-3-(3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)- 4-fluorophenoxy)-5-fluorophenyl)acrylonitrile (JLJ506), A Non-nucleoside inhibitor |
| 3HVT | 1994-10-15 | 2.9 | STRUCTURAL BASIS OF ASYMMETRY IN THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE HETERODIMER |
| 1SV5 | 2004-05-11 | 2.9 | CRYSTAL STRUCTURE OF K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R165335 |
| 6BHR | 2018-08-08 | 2.91 | HIV-1 immature CTD-SP1 hexamer in complex with IP6 |
| 5NME | 2017-11-15 | 2.94 | 868 TCR in complex with HLA A02 presenting SLYNTVATL |
| 3E01 | 2008-11-25 | 2.95 | HIV-RT with non-nucleoside inhibitor annulated pyrazole 2 |
| 5HLF | 2016-02-10 | 2.95 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A 38-MER HAIRPIN TEMPLATE-PRIMER DNA APTAMER AND AN ALPHA-CARBOXYPHOSPHONATE INHIBITOR |
| 2BAN | 2005-12-06 | 2.95 | Crystal structure of HIV-1 reverse transcriptase (RT) in complex with JANSSEN-R157208 |
| 3NBP | 2010-08-18 | 2.95 | HIV-1 reverse transcriptase with aminopyrimidine inhibitor 2 |
| 6OBH | 2019-08-28 | 2.96 | Structure of HIV-1 CA 1/2-hexamer |
| 3I0R | 2009-08-25 | 2.98 | crystal structure of HIV reverse transcriptase in complex with inhibitor 3 |
| 6P2G | 2019-07-24 | 2.99 | Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and D-ddCTP |
| 4RW9 | 2015-04-29 | 2.99 | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) variant in complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ532), a non-nucleoside inhibitor |
| 5I3U | 2016-06-01 | 3.0 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE N-SITE COMPLEX; CATALYTIC INCORPORATION OF AZTMP to A DNA aptamer in CRYSTAL |
| 1RTI | 1996-04-03 | 3.0 | HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES |
| 6N3J | 2018-12-12 | 3.0 | MicroED Structure of the CTD-SP1 fragment of HIV-1 Gag |
| 1HYS | 2001-03-26 | 3.0 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A POLYPURINE TRACT RNA:DNA |
| 1RT3 | 1999-02-16 | 3.0 | AZT DRUG RESISTANT HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH 1051U91 |
| 1JLB | 2001-10-03 | 3.0 | CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE |
| 1LW2 | 2002-10-30 | 3.0 | CRYSTAL STRUCTURE OF T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH 1051U91 |
| 1TVR | 1997-03-12 | 3.0 | HIV-1 RT/9-CL TIBO |
| 1HPZ | 2001-05-30 | 3.0 | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 |
| 1E28 | 2000-09-12 | 3.0 | Nonstandard peptide binding of HLA-B*5101 complexed with HIV immunodominant epitope KM2(TAFTIPSI) |
| 1N6Q | 2003-01-14 | 3.0 | HIV-1 Reverse Transcriptase Crosslinked to pre-translocation AZTMP-terminated DNA (complex N) |
| 1S6Q | 2004-05-11 | 3.0 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R147681 |
| 1AUM | 1998-01-14 | 3.0 | HIV CAPSID C-TERMINAL DOMAIN (CAC146) |
| 1SUQ | 2004-05-11 | 3.0 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R185545 |
| 2HNZ | 2006-09-05 | 3.0 | Crystal Structure of E138K Mutant HIV-1 Reverse Transcriptase in Complex with PETT-2 |
| 3JSM | 2009-09-29 | 3.0 | K65R mutant HIV-1 reverse transcriptase cross-linked to DS-DNA and complexed with tenofovir-diphosphate as the incoming nucleotide substrate |
| 1RT7 | 1999-07-29 | 3.0 | HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC84 |
| 2UPJ | 1996-10-14 | 3.0 | HIV-1 PROTEASE COMPLEX WITH U100313 ([3-[[3-[CYCLOPROPYL [4-HYDROXY-2OXO-6-[1-(PHENYLMETHYL)PROPYL]-2H-PYRAN-3-YL] METHYL]PHENYL]AMINO]-3-OXO-PROPYL]CARBAMIC ACID TERT-BUTYL ESTER) |
| 2IC3 | 2006-12-19 | 3.0 | Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with Nonnucleoside Inhibitor HBY 097 |
| 4U0D | 2014-11-12 | 3.0 | Hexameric HIV-1 CA in complex with Nup153 peptide, P212121 crystal form |
| 1JLC | 2001-10-03 | 3.0 | CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-2 |
| 1YT9 | 2005-04-12 | 3.0 | HIV Protease with oximinoarylsulfonamide bound |
| 1JLQ | 2001-08-22 | 3.0 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH 739W94 |
| 5UV5 | 2017-08-16 | 3.0 | Crystal Structure of a 2-Hydroxyisoquinoline-1,3-dione RNase H Active Site Inhibitor with Multiple Binding Modes to HIV Reverse Transcriptase |
| 1T05 | 2004-05-11 | 3.0 | HIV-1 reverse transcriptase crosslinked to template-primer with tenofovir-diphosphate bound as the incoming nucleotide substrate |
| 1S1U | 2004-06-29 | 3.0 | Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with nevirapine |
| 2HVP | 1989-04-19 | 3.0 | THREE-DIMENSIONAL STRUCTURE OF ASPARTYL PROTEASE FROM HUMAN IMMUNODEFICIENCY VIRUS HIV-1 |
| 1DTT | 2000-04-02 | 3.0 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-2 (PETT130A94) |
| 1IKW | 2001-06-06 | 3.0 | Wild Type HIV-1 Reverse Transcriptase in Complex with Efavirenz |
| 5W5W | 2018-06-20 | 3.0 | HIV Protease (PR) in open form with Mg2+ in active site and HIVE-9 in eye site |
| 1IKY | 2001-06-06 | 3.0 | HIV-1 Reverse Transcriptase in Complex with the Inhibitor MSC194 |
| 4PWD | 2014-06-18 | 3.0 | Crystal structure of HIV-1 reverse transcriptase in complex with bulge-RNA/DNA and Nevirapine |
| 1HNV | 1995-07-10 | 3.0 | STRUCTURE OF HIV-1 RT(SLASH)TIBO R 86183 COMPLEX REVEALS SIMILARITY IN THE BINDING OF DIVERSE NONNUCLEOSIDE INHIBITORS |
| 1IKV | 2001-06-06 | 3.0 | K103N Mutant HIV-1 Reverse Transcriptase in Complex with Efivarenz |
| 4RW7 | 2015-04-29 | 3.01 | Crystal Structure of HIV-1 Reverse Transcriptase (K103N, Y181C) variant in complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ532), a non-nucleoside inhibitor |
| 2VG6 | 2007-12-11 | 3.01 | Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors |
| 5HBM | 2016-02-24 | 3.04 | Crystal Structure of a Dihydroxycoumarin RNase H Active-Site Inhibitor in Complex with HIV-1 Reverse Transcriptase |
| 6CQR | 2018-06-06 | 3.04 | Crystal structure of F24 TCR -DR1-RQ13 peptide complex |
| 3GGV | 2009-05-26 | 3.09 | HIV Protease, pseudo-symmetric inhibitors |
| 1T03 | 2004-05-11 | 3.1 | HIV-1 reverse transcriptase crosslinked to tenofovir terminated template-primer (complex P) |
| 5HGL | 2016-08-10 | 3.1 | Hexameric HIV-1 CA, open conformation |
| 5FDL | 2016-02-17 | 3.1 | Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with IDX899 |
| 1N5Y | 2003-01-28 | 3.1 | HIV-1 Reverse Transcriptase Crosslinked to Post-Translocation AZTMP-Terminated DNA (Complex P) |
| 4LSN | 2013-12-25 | 3.1 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-bromo-5-(4-chloro-2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ518), a non-nucleoside inhibitor |
| 3KJV | 2010-03-23 | 3.1 | HIV-1 reverse transcriptase in complex with DNA |
| 3W39 | 2013-02-13 | 3.1 | Crystal structure of HLA-B*5201 in complexed with HIV immunodominant epitope (TAFTIPSI) |
| 1FQX | 2001-03-14 | 3.1 | CRYSTAL STRUCTURE OF THE COMPLEX OF HIV-1 PROTEASE WITH A PEPTIDOMIMETIC INHIBITOR |
| 1MF8 | 2002-10-16 | 3.1 | Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin |
| 1BQM | 1999-01-06 | 3.1 | HIV-1 RT/HBY 097 |
| 3KLF | 2010-09-22 | 3.15 | Crystal structure of wild-type HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA |
| 2I5J | 2006-12-05 | 3.15 | Crystal structure of HIV-1 reverse transcriptase (RT) in complex with DHBNH, an RNASE H inhibitor |
| 3DRS | 2008-10-14 | 3.15 | HIV reverse transcriptase K103N mutant in complex with inhibitor R8D |
| 3KLE | 2010-09-22 | 3.2 | Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA |
| 6MQO | 2019-06-19 | 3.2 | Structure of HIV-1 CA G208R |
| 2WOM | 2010-08-11 | 3.2 | Crystal Structure of UK-453061 bound to HIV-1 Reverse Transcriptase (K103N). |
| 6MQA | 2019-06-19 | 3.2 | Structure of HIV-1 CA P207S |
| 1HMV | 1995-03-31 | 3.2 | THE STRUCTURE OF UNLIGANDED REVERSE TRANSCRIPTASE FROM THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 |
| 1RTD | 1998-12-09 | 3.2 | STRUCTURE OF A CATALYTIC COMPLEX OF HIV-1 REVERSE TRANSCRIPTASE: IMPLICATIONS FOR NUCLEOSIDE ANALOG DRUG RESISTANCE |
| 1UWB | 1997-05-15 | 3.2 | TYR 181 CYS HIV-1 RT/8-CL TIBO |
| 6BSI | 2018-01-03 | 3.25 | Structure of HIV-1 RT complexed with an RNA/DNA hybrid containing the polypurine-tract sequence |
| 5I42 | 2016-06-01 | 3.3 | Structure of HIV-1 Reverse Transcriptase in complex with a DNA aptamer, AZTTP, and CA(2+) ion |
| 4Q0B | 2014-06-18 | 3.3 | Crystal structure of HIV-1 reverse transcriptase in complex with gap-RNA/DNA and Nevirapine |
| 6MQP | 2019-06-19 | 3.3 | Structure of HIV-1 CA T210K |
| 3JYT | 2009-10-06 | 3.3 | K65R mutant HIV-1 reverse transcriptase cross-linked to DS-DNA and complexed with DATP as the incoming nucleotide substrate |
| 1BQN | 1999-01-06 | 3.3 | TYR 188 LEU HIV-1 RT/HBY 097 |
| 4B3O | 2013-01-16 | 3.3 | Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface |
| 6DTX | 2019-07-31 | 3.33 | Wildtype HIV-1 Reverse Transcriptase in complex with JLJ 578 |
| 6BJ2 | 2018-07-25 | 3.35 | TCR589 in complex with HIV(Pol448-456)/HLA-B35 |
| 6V3K | 2020-02-12 | 3.4 | Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and INSTI XZ419 (compound 4c) |
| 1P7Q | 2003-10-14 | 3.4 | Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor |
| 6ECN | 2019-08-21 | 3.4 | HIV-1 CA 1/2-hexamer-EE |
| 6EC2 | 2019-08-21 | 3.4 | Structure of HIV-1 CA 1/3-hexamer |
| 1J5O | 2002-06-14 | 3.5 | CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE-PRIMER |
| 5C42 | 2015-11-11 | 3.5 | Crystal Structure of HIV-1 Reverse Transcriptase (K101P) Variant in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)indolizine-2-carbonitrile (JLJ555), a non-nucleoside inhibitor |
| 3KLG | 2010-09-22 | 3.65 | Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to pre-translocation AZTMP-Terminated DNA (COMPLEX N) |
| 1AFV | 1997-08-20 | 3.7 | HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3 |
| 5U1C | 2017-01-11 | 3.9 | Structure of tetrameric HIV-1 Strand Transfer Complex Intasome |
| 5L93 | 2016-07-13 | 3.9 | An atomic model of HIV-1 CA-SP1 reveals structures regulating assembly and maturation |
| 6HAK | 2019-04-03 | 3.95 | Crystal structure of HIV-1 reverse transcriptase (RT) in complex with a double stranded RNA represents the RT transcription initiation complex prior to nucleotide incorporation |
| 3DTJ | 2008-09-02 | 4.0 | HIV-1 capsid C-terminal domain mutant (E187A) |
| 6Y9W | 2020-08-19 | 4.1 | Structure of the native full-length HIV-1 capsid protein in complex with Cyclophilin A from helical assembly (-13,8) |
| 6WAZ | 2020-06-24 | 4.1 | +1 extended HIV-1 reverse transcriptase initiation complex core (pre-translocation state) |
| 6WB0 | 2020-06-24 | 4.2 | +3 extended HIV-1 reverse transcriptase initiation complex core (pre-translocation state) |
| 6ECO | 2019-09-18 | 4.2 | Hexamer-2-Foldon HIV-1 capsid platform |
| 6Y9X | 2020-08-19 | 4.4 | Structure of the native full-length HIV-1 capsid protein in complex with Cyclophilin A from helical assembly (-13,7) |
| 6VDK | 2020-02-05 | 4.5 | CryoEM structure of HIV-1 conserved Intasome Core |
| 6WB2 | 2020-06-24 | 4.5 | +3 extended HIV-1 reverse transcriptase initiation complex core (displaced state) |
| 6B19 | 2018-04-25 | 4.5 | Architecture of HIV-1 reverse transcriptase initiation complex core |
| 6U8Q | 2020-02-05 | 4.67 | CryoEM structure of HIV-1 cleaved synaptic complex (CSC) intasome |
| 6WB1 | 2020-06-24 | 4.7 | +3 extended HIV-1 reverse transcriptase initiation complex core (intermediate state) |
| 1HVU | 1999-01-13 | 4.75 | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE COMPLEXED WITH A 33-BASE NUCLEOTIDE RNA PSEUDOKNOT |
| 6Y9Z | 2020-08-19 | 4.8 | Structure of the native full-length HIV-1 capsid protein in complex with Cyclophilin A from helical assembly (-13,9) |
| 4B3P | 2013-01-16 | 4.84 | Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface |
| 4B3Q | 2013-01-16 | 5.0 | Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface |
| 5UPW | 2017-03-01 | 5.0 | CryoEM Structure Refinement by Integrating NMR Chemical Shifts with Molecular Dynamics Simulations |
| 5KP9 | 2016-12-07 | 5.7 | Structure of Nanoparticle Released from Enveloped Protein Nanoparticle |
| 6ZDJ | 2020-08-19 | 5.8 | Structure of the native full-length HIV-1 capsid protein in complex with Cyclophilin A from helical assembly (-13,10) |
| 3P0A | 2011-01-12 | 5.95 | X-ray structure of pentameric HIV-1 CA |
| 6Y9Y | 2020-08-19 | 6.1 | Structure of the native full-length HIV-1 capsid protein in complex with Cyclophilin A from helical assembly (-7,13) |
| 6Y9V | 2020-08-19 | 6.9 | Structure of the native full-length HIV-1 capsid protein in complex with Cyclophilin A from helical assembly (-8,13) |
| 3GV2 | 2009-06-23 | 7.0 | X-ray Structure of Hexameric HIV-1 CA |
| 5FJB | 2016-03-16 | 9.0 | Cyclophilin A Stabilize HIV-1 Capsid through a Novel Non- canonical Binding Site |
Relevant UniProtKB Entries
| Percent Identity | Matching Chains | Protein | Accession | Entry Name |
|---|---|---|---|---|
| 200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P62938 | PPIA_CHLAE |
| 200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q0ZQL0 | PPIA_GORGO |
| 200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P62937 | PPIA_HUMAN |
| 200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q0ZQK8 | PPIA_HYLLA |
| 200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P62940 | PPIA_MACMU |
| 200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q0ZQK7 | PPIA_NOMLE |
| 200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q0ZQL2 | PPIA_PANPA |
| 200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q0ZQL1 | PPIA_PANTR |
| 200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P62941 | PPIA_PAPAN |
| 200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q5R8S7 | PPIA_PONPY |
| 200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q0ZQK6 | PPIA_SYMSY |
| 197.6 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P62935 | PPIA_BOVIN |
| 197.6 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P62936 | PPIA_PIG |
| 197.6 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q6DTV9 | PPIA_AOTTR |
| 197.6 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q0ZQK3 | PPIA_SAGOE |
| 194.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q8HXS3 | PPIA_FELCA |
| 194.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P14851 | PPIA_CRIGR |
| 192.6 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9TTC6 | PPIA_RABIT |
| 192.6 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P17742 | PPIA_MOUSE |
| 192.6 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P10111 | PPIA_RAT |
| 200.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P12493 | GAG_HV1N5 |
| 200.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P12497 | POL_HV1N5 |
| 198.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P05890 | GAG_HV1RH |
| 198.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P05889 | GAG_HV1W2 |
| 198.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P35962 | GAG_HV1Y2 |
| 198.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P05959 | POL_HV1RH |
| 198.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P35963 | POL_HV1Y2 |
| 197.2 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P20873 | GAG_HV1JR |
| 197.2 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P20875 | POL_HV1JR |
| 197.2 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P03349 | GAG_HV1A2 |
| 197.2 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P03369 | POL_HV1A2 |
| 195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P03347 | GAG_HV1B1 |
| 195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P04593 | GAG_HV1B5 |
| 195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P03348 | GAG_HV1BR |
| 195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P04591 | GAG_HV1H2 |
| 195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q70622 | GAG_HV1LW |
| 195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P03366 | POL_HV1B1 |
| 195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P04587 | POL_HV1B5 |
| 195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P03367 | POL_HV1BR |
| 195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P04585 | POL_HV1H2 |
| 195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P0C6F2 | POL_HV1LW |
| 195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P05888 | GAG_HV1MN |
| 195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P20889 | GAG_HV1OY |
| 195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P20892 | POL_HV1OY |
| 194.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P05887 | GAG_HV1C4 |
| 195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P12495 | GAG_HV1Z2 |
| 194.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P05960 | POL_HV1C4 |
| 194.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P05961 | POL_HV1MN |
| 195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P12499 | POL_HV1Z2 |
| 194.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q73367 | GAG_HV1B9 |
| 194.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q73368 | POL_HV1B9 |
| 194.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P04592 | GAG_HV1EL |
| 194.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P04589 | POL_HV1EL |
| 193.2 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P18800 | GAG_HV1ND |
| 193.2 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P18802 | POL_HV1ND |
| 194.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P12494 | GAG_HV1J3 |
| 194.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P12498 | POL_HV1J3 |
| 189.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9WC53 | GAG_HV1S2 |
| 189.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9WC54 | POL_HV1S2 |
| 189.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9QBZ6 | GAG_HV1MP |
| 189.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9QBZ5 | POL_HV1MP |
| 187.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9QBY4 | GAG_HV196 |
| 187.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9QBZ2 | GAG_HV1M2 |
| 187.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9QBY3 | POL_HV196 |
| 187.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9QBZ1 | POL_HV1M2 |
| 186.2 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9WC62 | GAG_HV1S9 |
| 186.2 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9WC63 | POL_HV1S9 |
| 189.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9Q721 | GAG_HV1V9 |
| 189.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9Q720 | POL_HV1V9 |
| 187.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | O12157 | GAG_HV192 |
| 187.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | O12158 | POL_HV192 |
| 187.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9QC00 | GAG_HV197 |
| 187.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9QBZ9 | POL_HV197 |
| 184.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q75001 | GAG_HV1ET |
| 184.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P04594 | GAG_HV1MA |
| 184.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q75002 | POL_HV1ET |
| 184.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P04588 | POL_HV1MA |
| 184.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9QSR4 | GAG_HV1VI |
| 184.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9QSR3 | POL_HV1VI |
| 187.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | O93182 | GAG_HV190 |
| 187.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | O93215 | POL_HV190 |
| 183.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q1A268 | GAG_SIVMB |
| 183.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q1A267 | POL_SIVMB |
| 183.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | O89291 | GAG_HV193 |
| 183.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | O89290 | POL_HV193 |
| 183.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P24736 | GAG_HV1U4 |
| 183.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P24740 | POL_HV1U4 |
| 182.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P0C1K7 | GAG_HV19N |
| 182.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | O89939 | GAG_HV1SE |
| 182.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | O41798 | POL_HV19N |
| 182.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | O89940 | POL_HV1SE |