The HIV-1 capsid protein (CA) makes an essential interaction with the human peptidyl prolyl isomerase, cyclophilin A (CypA), that results in packaging of CypA into the virion at a CA to CypA stoichiometry of approximately 10:1. The 231 amino acid residue capsid protein is composed of an amino-terminal CypA binding domain (1 to approximately 151; CA151) and a carboxyl-terminal dimerization domain (approximately 151 to 231). We find that CypA binds dimeric CA and monomeric CA151 with identical intrinsic affinities (K[d] = 16(+/-4) microM). This result demonstrates that capsid dimerization and cyclophilin A binding are not thermodynamically coupled and suggests that the substoichiometric ratio of CypA in the HIV-1 virion results from the intrinsic stability of the CA/CypA complex. In the known co-crystal structure of the CA151/CypA complex, CypA binding is mediated exclusively by an exposed capsid loop that spans residues Pro85 to Pro93. The energetic contributions to CypA binding were quantified for each residue in this loop, and the results demonstrate that the Gly89-Pro90 dipeptide is the primary cyclophilin A recognition motif, with Pro85, Val86, His87, Ala88, and Pro93 also making energetically favorable contacts. These studies reveal that the active site of CypA, which can catalyze the isomerization of proline residues in vitro, also functions as a sequence-specific, protein-binding motif in HIV-1 replication.
ID: AXsUwn94
Submitter: Shu-Ching Ou
Submission Date: Feb. 22, 2019, 12:13 p.m.
Version: 1
Two sets of ΔΔG values are reported. One is from direct calculations using relative Kd, and the other set is reported from the AB-Bind article (DOI: 10.1002/pro.2829)
Number of data points | 84 |
Proteins | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein |
Unique complexes | 17 |
Assays/Quantities/Protocols | Experimental Assay: Kd ; Derived Quantity: ΔΔG_AB-Bind ; Derived Quantity: ΔΔG ; Derived Quantity: Fold decrease in Kd ; Derived Quantity: SD of Kd |
Libraries | Variants for CypA-CA |
Colors: | D | E | R | H | K | S | T | N | Q | A | V | I | L | M | F | Y | W | C | G | P |
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Structure ID | Release Date | Resolution | Structure Title |
---|---|---|---|
2C55 | 2005-11-02 | Solution Structure of the Human Immunodeficiency Virus Type 1 p6 Protein | |
2HMX | 1996-01-29 | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 MATRIX PROTEIN | |
4JEC | 2013-07-24 | Joint neutron and X-ray structure of per-deuterated HIV-1 protease in complex with clinical inhibitor amprenavir | |
2JYG | 2008-02-26 | Solution Structure of the W184A/M185A Mutant of the Carboxy-terminal Dimerization Domain of the HIV-1 Capsid Protein | |
1Q9P | 2004-03-02 | Solution structure of the mature HIV-1 protease monomer | |
2MS4 | 2015-09-09 | Cyclophilin a complexed with a fragment of crk-ii | |
1BVG | 1996-08-17 | HIV-1 PROTEASE-DMP323 COMPLEX IN SOLUTION, NMR MINIMIZED AVERAGE STRUCTURE | |
2MZU | 2015-04-22 | Extending the eNOE data set of large proteins by evaluation of NOEs with unresolved diagonals | |
2L6E | 2010-12-29 | NMR Structure of the monomeric mutant C-terminal domain of HIV-1 Capsid in complex with stapled peptide Inhibitor | |
1WJE | 1998-12-16 | SOLUTION STRUCTURE OF H12C MUTANT OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE COMPLEXED TO CADMIUM, NMR, MINIMIZED AVERAGE STRUCTURE | |
5IRT | 2016-06-22 | Dimerization interface of the noncrystalline HIV-1 capsid protein lattice from solid state NMR spectroscopy of tubular assemblies | |
1TAM | 1996-07-11 | HUMAN IMMUNODEFICIENCY VIRUS, NMR, MINIMIZED AVERAGE STRUCTURE | |
1NCP | 1993-10-31 | STRUCTURAL CHARACTERIZATION OF A 39 RESIDUE SYNTHETIC PEPTIDE CONTAINING THE TWO ZINC BINDING DOMAINS FROM THE HIV-1 P7 NUCLEOCAPSID PROTEIN BY CD AND NMR SPECTROSCOPY | |
2M3Z | 2013-02-27 | NMR solution structure of HIV-1 nucleocapsid protein in complex with an inhibitor displaying a 2 inhibitors:1 NC stoichiometry | |
2M8N | 2013-11-20 | HIV-1 capsid monomer structure | |
2M8P | 2013-11-20 | The structure of the W184AM185A mutant of the HIV-1 capsid protein | |
1WJC | 1998-05-13 | SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (E FORM), NMR, REGULARIZED MEAN STRUCTURE | |
2L4L | 2010-12-08 | Structural insights into the cTAR DNA recognition by the HIV-1 Nucleocapsid protein: role of sugar deoxyriboses in the binding polarity of NC | |
1UPH | 2004-01-08 | HIV-1 Myristoylated Matrix | |
1AAF | 1994-01-31 | NUCLEOCAPSID ZINC FINGERS DETECTED IN RETROVIRUSES: EXAFS STUDIES ON INTACT VIRUSES AND THE SOLUTION-STATE STRUCTURE OF THE NUCLEOCAPSID PROTEIN FROM HIV-1 | |
1HVO | 1994-01-31 | ZINC-AND SEQUENCE-DEPENDENT BINDING TO NUCLEIC ACIDS BY THE N-TERMINAL ZINC FINGER DOMAIN OF THE HIV-1 NUCLEOCAPSID PROTEIN: NMR STRUCTURE OF THE COMPLEX WITH THE PSI-SITE ANALOG, D/ACGCC | |
3DIK | 2008-09-16 | Pseudo-atomic model of the HIV-1 CA hexameric lattice | |
1WJB | 1998-05-13 | SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (D FORM), NMR, 40 STRUCTURES | |
5E5K | 2016-05-04 | Joint X-ray/neutron structure of HIV-1 protease triple mutant (V32I,I47V,V82I) with darunavir at pH 4.3 | |
2EXF | 2007-04-24 | Solution structure of the HIV-1 nucleocapsid (NCp7(12-55)) complexed with the DNA (-) Primer Binding Site | |
1O1W | 2003-02-18 | SOLUTION STRUCTURE OF THE RNASE H DOMAIN OF THE HIV-1 REVERSE TRANSCRIPTASE IN THE PRESENCE OF MAGNESIUM | |
3CYS | 1994-08-31 | DETERMINATION OF THE NMR SOLUTION STRUCTURE OF THE CYCLOPHILIN A-CYCLOSPORIN A COMPLEX | |
2L45 | 2011-12-14 | C-terminal zinc knuckle of the HIVNCp7 with DNA | |
2M8L | 2013-11-20 | HIV capsid dimer structure | |
1U57 | 2005-02-08 | NMR structure of the (345-392)Gag sequence from HIV-1 | |
1QMC | 1999-12-14 | C-terminal DNA-binding domain of HIV-1 integrase, NMR, 42 structures | |
1WJD | 1998-05-13 | SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (E FORM), NMR, 38 STRUCTURES | |
2N0T | 2015-08-26 | Structural ensemble of the enzyme cyclophilin reveals an orchestrated mode of action at atomic resolution | |
1WJF | 1998-12-16 | SOLUTION STRUCTURE OF H12C MUTANT OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE COMPLEXED TO CADMIUM, NMR, 40 STRUCTURES | |
1GWP | 2002-06-21 | STRUCTURE OF THE N-TERMINAL DOMAIN OF THE MATURE HIV-1 CAPSID PROTEIN | |
2JZW | 2009-01-13 | How the HIV-1 nucleocapsid protein binds and destabilises the (-)primer binding site during reverse transcription | |
2JPR | 2007-10-09 | Joint refinement of the HIV-1 CA-NTD in complex with the assembly inhibitor CAP-1 | |
2LF4 | 2011-11-09 | Structure of a monomeric mutant of the HIV-1 capsid protein | |
1WJA | 1998-05-13 | SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (D FORM), NMR, REGULARIZED MEAN STRUCTURE | |
2KOD | 2009-11-24 | A high-resolution NMR structure of the dimeric C-terminal domain of HIV-1 CA | |
6N3U | 2018-12-12 | MicroED Structure of the CTD-SP1 fragment of HIV-1 Gag with bound maturation inhibitor Bevirimat. | |
5I1R | 2016-03-30 | Quantitative characterization of configurational space sampled by HIV-1 nucleocapsid using solution NMR and X-ray scattering | |
1HVN | 1994-01-31 | ZINC-AND SEQUENCE-DEPENDENT BINDING TO NUCLEIC ACIDS BY THE N-TERMINAL ZINC FINGER DOMAIN OF THE HIV-1 NUCLEOCAPSID PROTEIN: NMR STRUCTURE OF THE COMPLEX WITH THE PSI-SITE ANALOG, D/ACGCC | |
2LYB | 2013-02-13 | Structure of HIV-1 myr(-) matrix protein in complex with 1,2-dioctanoyl-sn-phosphatidyl-L-serine | |
1ESK | 2000-04-26 | SOLUTION STRUCTURE OF NCP7 FROM HIV-1 | |
2JYL | 2008-02-12 | Solution Structure of A Double Mutant of The Carboxy-terminal Dimerization Domain of The HIV-1 Capsid Protein | |
1MFS | 1998-06-17 | DYNAMICAL BEHAVIOR OF THE HIV-1 NUCLEOCAPSID PROTEIN; NMR, 30 STRUCTURES | |
2LYA | 2013-02-13 | Structure of HIV-1 myr(-) matrix protein in complex with 1,2-dioctanoyl-sn-phosphatidylcholine | |
2H3F | 2006-07-25 | Solution structure of the HIV-1 MA protein | |
2H3V | 2006-07-25 | Structure of the HIV-1 Matrix protein bound to di-C8-phosphatidylinositol-(4,5)-bisphosphate | |
2L46 | 2011-12-14 | C-terminal zinc finger of the HIVNCp7 with platinated DNA | |
2H3Z | 2006-07-25 | Structure of the HIV-1 matrix protein bound to di-C4-phosphatidylinositol-(4,5)-bisphosphate | |
1OCA | 1997-11-19 | HUMAN CYCLOPHILIN A, UNLIGATED, NMR, 20 STRUCTURES | |
2H3I | 2006-07-25 | Solution structure of the HIV-1 myristoylated Matrix protein | |
1F6U | 2000-10-09 | NMR structure of the HIV-1 nucleocapsid protein bound to stem-loop sl2 of the psi-RNA packaging signal. Implications for genome recognition | |
2H3Q | 2006-07-25 | Solution structure of HIV-1 myrMA bound to di-C4-phosphatidylinositol-(4,5)-bisphosphate | |
5T82 | 2017-01-18 | HIV-1 reverse transcriptase thumb subdomain | |
1BVE | 1996-08-17 | HIV-1 PROTEASE-DMP323 COMPLEX IN SOLUTION, NMR, 28 STRUCTURES | |
5YOK | 2018-07-18 | 0.85 | Structure of HIV-1 Protease in Complex with Inhibitor KNI-1657 |
3A2O | 2010-03-02 | 0.88 | Crystal Structure of HIV-1 Protease Complexed with KNI-1689 |
3FX5 | 2009-03-24 | 0.93 | Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by High Resolution X-ray Crystallography |
3DJK | 2008-09-30 | 1.0 | Wild Type HIV-1 Protease with potent Antiviral inhibitor GRL-0255A |
3NU3 | 2010-08-25 | 1.02 | Wild Type HIV-1 Protease with Antiviral Drug Amprenavir |
3NDX | 2011-07-20 | 1.03 | HIV-1 Protease Saquinavir:Ritonavir 1:50 complex structure |
1NH0 | 2004-04-13 | 1.03 | 1.03 A structure of HIV-1 protease: inhibitor binding inside and outside the active site |
2J9J | 2007-08-28 | 1.04 | Atomic-resolution Crystal Structure of Chemically-Synthesized HIV-1 Protease Complexed with Inhibitor JG-365 |
3D1Y | 2008-05-27 | 1.05 | Crystal structure of HIV-1 mutant I54V and inhibitor SAQUINA |
3BVA | 2008-04-01 | 1.05 | Cystal structure of HIV-1 Active Site Mutant D25N and p2-NC analog inhibitor |
3D1X | 2008-06-03 | 1.05 | Crystal structure of HIV-1 mutant I54M and inhibitor saquinavir |
3D20 | 2008-05-27 | 1.05 | Crystal structure of HIV-1 mutant I54V and inhibitor DARUNAVIA |
4HE9 | 2013-08-21 | 1.06 | Crystal Structure of HIV-1 protease mutants I54M complexed with inhibitor GRL-0519 |
3DK1 | 2009-05-12 | 1.07 | Wild Type HIV-1 Protease with potent Antiviral inhibitor GRL-0105A |
2JE4 | 2007-08-28 | 1.07 | Atomic-resolution crystal structure of chemically-synthesized HIV-1 protease in complex with JG-365 |
1KZK | 2002-04-03 | 1.09 | JE-2147-HIV Protease Complex |
2AOG | 2006-01-17 | 1.1 | Crystal structure analysis of HIV-1 protease mutant V82A with a substrate analog P2-NC |
2AVO | 2006-01-24 | 1.1 | Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S |
2AVM | 2006-01-24 | 1.1 | Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S |
4EJD | 2013-05-01 | 1.1 | HIV Protease (PR) dimer in closed form with pepstatin in active site and fragment 1F1 in the outside/top of flap |
2AVS | 2006-01-24 | 1.1 | kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, and G73S |
2QD7 | 2008-04-22 | 1.11 | HIV-1 Protease Mutant V82A with potent Antiviral inhibitor GRL-98065 |
4ZIP | 2015-07-15 | 1.11 | HIV-1 wild Type protease with GRL-0648A (a isophthalamide-derived P2-Ligand) |
3TOH | 2012-08-15 | 1.12 | HIV-1 Protease - Epoxydic Inhibitor Complex (pH 9 - Orthorombic Crystal form P212121) |
3DS4 | 2008-09-02 | 1.12 | HIV-1 capsid C-terminal domain mutant (L211S) in complex with an inhibitor of particle assembly (CAI) |
6DV4 | 2018-10-31 | 1.14 | HIV-1 wild type protease with GRL-04315A, a tetrahydronaphthalene carboxamide with (R)-Boc-amine and (S)-hydroxyl functionalities as the P2 ligand |
3NDW | 2011-07-20 | 1.14 | HIV-1 Protease Saquinavir:Ritonavir 1:15 complex structure |
4N1M | 2015-08-12 | 1.15 | Structure of Cyclophilin A in complex with GlyPro. |
5F66 | 2015-12-30 | 1.15 | High-resolution isotropic multiconformer synchrotron model of CypA at 273 K |
6GS6 | 2019-06-26 | 1.16 | Cyclophilin A single mutant D66A in complex with an inhibitor. |
5JG1 | 2016-09-21 | 1.16 | HIV-1 wild Type protease with GRL-031-14A (a Adamantane P1-Ligand with tetrahydropyrano-tetrahydrofuran in P2 and isobutylamine in P1') |
6GJL | 2018-11-07 | 1.16 | Cyclophilin A complexed with tri-vector ligand 10. |
3NU6 | 2010-08-25 | 1.16 | Crystal Structure of HIV-1 Protease Mutant I54M with Antiviral Drug Amprenavir |
3I6O | 2009-09-29 | 1.17 | Crystal structure of wild type HIV-1 protease with macrocyclic inhibitor GRL-0216A |
4MC9 | 2014-04-02 | 1.19 | HIV protease in complex with AA74 |
3DS2 | 2008-09-02 | 1.2 | HIV-1 capsid C-terminal domain mutant (Y169A) |
6DV0 | 2018-10-31 | 1.2 | HIV-1 wild type protease with GRL-02815A, a thiochroman heterocycle with (S)-Boc-amine functionality as the P2 ligand |
2X25 | 2010-03-23 | 1.2 | Free acetyl-CypA orthorhombic form |
2J9K | 2007-08-28 | 1.2 | Atomic-resolution Crystal Structure of Chemically-Synthesized HIV-1 Protease Complexed with Inhibitor MVT-101 |
1T3R | 2005-05-03 | 1.2 | HIV protease wild-type in complex with TMC114 inhibitor |
2R8N | 2008-07-29 | 1.2 | Structural Analysis of the Unbound Form of HIV-1 Subtype C Protease |
5AGZ | 2015-05-06 | 1.2 | Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II) |
4YUO | 2015-05-20 | 1.2 | High-resolution multiconformer synchrotron model of CypA at 273 K |
1K1T | 2002-07-10 | 1.2 | Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance |
4FL8 | 2012-10-17 | 1.2 | HIV-1 protease complexed with gem-diol-amine tetrahedral intermediate |
3NU4 | 2010-08-25 | 1.2 | Crystal Structure of HIV-1 Protease Mutant V32I with Antiviral Drug Amprenavir |
2QCI | 2008-04-22 | 1.2 | HIV-1 Protease mutant D30N with potent Antiviral inhibitor GRL-98065 |
6DIF | 2018-10-17 | 1.2 | Wild-type HIV-1 protease in complex with tipranavir |
3CYX | 2008-05-27 | 1.2 | Crystal structure of HIV-1 mutant I50V and inhibitor saquinavira |
6PRF | 2019-09-18 | 1.21 | HIV-1 Protease multiple drug resistant clinical isolate mutant PR20 with GRL-14213A |
2F8G | 2006-03-07 | 1.22 | HIV-1 protease mutant I50V complexed with inhibitor TMC114 |
4HDP | 2013-08-14 | 1.22 | Crystal Structure of HIV-1 protease mutants I50V complexed with inhibitor GRL-0519 |
6E9A | 2018-11-07 | 1.22 | HIV-1 WILD TYPE PROTEASE WITH GRL-034-17A, (3aS, 5R, 6aR)-2-OXOHEXAHYD CYCLOPENTA[D]-5-OXAZOLYL URETHANE WITH A BICYCLIC OXAZOLIDINONE SCAFF AS THE P2 LIGAND |
5DGU | 2015-10-28 | 1.22 | Crystal Structure of HIV-1 Protease Inhibitors Containing Substituted fused-Tetrahydropyranyl Tetrahydrofuran as P2-Ligand GRL-004-11A |
4DFG | 2012-03-21 | 1.23 | Crystal Structure of Wild-type HIV-1 Protease with Cyclopentyltetrahydro- furanyl Urethanes as P2-ligand, GRL-0249A |
3TOG | 2012-08-15 | 1.24 | HIV-1 Protease - Epoxydic Inhibitor Complex (pH 9 - Monoclinic Crystal form P21) |
1SDU | 2004-05-25 | 1.25 | Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site. |
3VF5 | 2012-11-21 | 1.25 | Crystal Structure of HIV-1 Protease Mutant I47V with novel P1'-Ligands GRL-02031 |
3K0M | 2009-12-08 | 1.25 | Cryogenic structure of CypA |
2F81 | 2006-03-07 | 1.25 | HIV-1 Protease mutant L90M complexed with inhibitor TMC114 |
5LUD | 2017-04-05 | 1.25 | Structure of Cyclophilin A in complex with 2,3-Diaminopyridine |
3NDU | 2011-07-20 | 1.25 | HIV-1 Protease Saquinavir:Ritonavir 1:5 complex structure |
5AH8 | 2015-05-06 | 1.26 | Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II) |
6DJ1 | 2018-10-17 | 1.26 | Wild-type HIV-1 protease in complex with Lopinavir |
5UPZ | 2017-05-10 | 1.27 | HIV-1 wild Type protease with GRL-0518A , an isophthalamide-derived P2-P3 ligand with the para-hydoxymethyl sulfonamide isostere as the P2' group |
3OK9 | 2010-09-22 | 1.27 | Crystal structure of wild-type HIV-1 protease with new oxatricyclic designed inhibitor GRL-0519A |
2QD6 | 2008-04-22 | 1.28 | HIV-1 Protease Mutant I50V with potent Antiviral inhibitor GRL-98065 |
3H5B | 2009-06-16 | 1.29 | Crystal structure of wild type HIV-1 protease with novel P1'-ligand GRL-02031 |
6GJY | 2018-11-07 | 1.29 | Cyclophilin A complexed with tri-vector ligand 5. |
5BS4 | 2015-09-09 | 1.29 | HIV-1 wild Type protease with GRL-047-11A (a methylamine bis-Tetrahydrofuran P2-Ligand, 4-amino sulfonamide derivative) |
4HDF | 2013-08-14 | 1.29 | Crystal Structure of HIV-1 protease mutants V82A complexed with inhibitor GRL-0519 |
3NU5 | 2010-08-25 | 1.29 | Crystal Structure of HIV-1 Protease Mutant I50V with Antiviral Drug Amprenavir |
3HAW | 2011-04-27 | 1.3 | Crystal structure of [L-Ala51/51']HIV-1 protease with reduced isostere MVT-101 inhibitor |
4YHQ | 2015-06-10 | 1.3 | Crystal structure of multidrug resistant clinical isolate PR20 with GRL-5010A |
4U8W | 2014-11-05 | 1.3 | HIV-1 wild Type protease with GRL-050-10A (a Gem-difluoro-bis-Tetrahydrofuran as P2-Ligand) |
2A1E | 2006-02-21 | 1.3 | High resolution structure of HIV-1 PR with TS-126 |
3D1Z | 2008-05-27 | 1.3 | Crystal structure of HIV-1 mutant I54M and inhibitor DARUNAVIR |
3BVB | 2008-04-01 | 1.3 | Cystal structure of HIV-1 Active Site Mutant D25N and inhibitor Darunavir |
3KFR | 2010-02-23 | 1.3 | HIV Protease (PR) dimer with inhibitor TL-3 bound and fragment 1F1 in the outside/top of flap |
4DQE | 2012-03-07 | 1.3 | Crystal Structure of (G16C/L38C) HIV-1 Protease in Complex with DRV |
2AVQ | 2006-01-24 | 1.3 | Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S |
3VF7 | 2012-11-21 | 1.3 | Crystal Structure of HIV-1 Protease Mutant L76V with novel P1'-Ligands GRL-02031 |
2IEN | 2006-10-03 | 1.3 | Crystal structure analysis of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) |
2AOC | 2006-01-17 | 1.3 | Crystal structure analysis of HIV-1 protease mutant I84V with a substrate analog P2-NC |
5NOU | 2017-07-12 | 1.3 | Structure of cyclophilin A in complex with hexahydropyrimidin-2-one |
6E7J | 2018-11-07 | 1.3 | HIV-1 wild type protease with GRL-042-17A, 3-phenylhexahydro-2h-cyclopenta[d]oxazol-2-one with a bicyclic oxazolidinone scaffold as the P2 ligand |
1SDT | 2004-05-25 | 1.3 | Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site. |
3HAU | 2011-04-27 | 1.3 | Crystal structure of chemically synthesized HIV-1 protease with reduced isostere MVT-101 inhibitor |
6FK1 | 2019-02-06 | 1.3 | Cyclophilin A |
4J55 | 2013-05-15 | 1.31 | Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical isolate PR20 with the potent antiviral inhibitor GRL-02031 |
4MC6 | 2014-04-02 | 1.31 | HIV protease in complex with SA499 |
4FLG | 2012-10-17 | 1.31 | HIV-1 protease mutant I47V complexed with reaction intermediate |
6DJ7 | 2018-10-17 | 1.31 | HIV-1 protease with mutation L76V in complex with GRL-5010 (gem-difluoro-bis-tetrahydrofuran as P2 ligand) |
2AOF | 2006-01-17 | 1.32 | Crystal structure analysis of HIV-1 Protease mutant V82A with a substrate analog P1-P6 |
3TL9 | 2012-04-25 | 1.32 | crystal structure of HIV protease model precursor/Saquinavir complex |
5UOV | 2017-05-10 | 1.33 | HIV-1 wild Type protease with GRL-1118A , an isophthalamide-derived P2-P3 ligand with the sulfonamide isostere as the P2' group |
2O4L | 2006-12-12 | 1.33 | Crystal Structure of HIV-1 Protease (Q7K, I50V) in Complex with Tipranavir |
3TH9 | 2011-09-28 | 1.34 | Crystal Structure of HIV-1 Protease Mutant Q7K V32I L63I with a cyclic sulfonamide inhibitor |
4YUH | 2015-10-14 | 1.34 | Multiconformer synchrotron model of CypA at 150 K |
5BRY | 2015-09-09 | 1.34 | HIV-1 wild Type protease with GRL-011-11A (a methylamine bis-Tetrahydrofuran P2-Ligand, sulfonamide isostere derivate) |
4YE3 | 2015-06-10 | 1.35 | Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 with Inhibitor GRL-4410A |
5NOS | 2017-07-12 | 1.35 | Structure of cyclophilin A in complex with 3-amino-1H-pyridin-2-one |
5AHA | 2015-05-06 | 1.35 | Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II) |
6GJM | 2018-11-07 | 1.35 | Cyclophilin A complexed with tri-vector ligand 4. |
2QD8 | 2008-04-22 | 1.35 | HIV-1 Protease Mutant I84V with potent Antiviral inhibitor GRL-98065 |
3NUO | 2010-08-25 | 1.35 | Crystal Structure of HIV-1 Protease Mutant L90M with Antiviral Drug Amprenavir |
2BB9 | 2005-11-15 | 1.35 | Structure of HIV1 protease and AKC4p_133a complex. |
1T7I | 2005-05-10 | 1.35 | The structural and thermodynamic basis for the binding of TMC114, a next-generation HIV-1 protease inhibitor. |
6DJ2 | 2018-10-17 | 1.36 | HIV-1 protease with single mutation L76V in complex with Lopinavir |
3TKG | 2012-04-25 | 1.36 | crystal structure of HIV model protease precursor/saquinavir complex |
3UCB | 2012-03-28 | 1.38 | Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Darunavir |
6GJJ | 2018-11-07 | 1.38 | Cyclophilin A complexed with tri-vector ligand 2. |
4U7V | 2015-03-25 | 1.38 | Structure of wild-type HIV protease in complex with degraded photosensitive inhibitor |
4YUI | 2015-10-14 | 1.38 | Multiconformer synchrotron model of CypA at 180 K |
4U1J | 2015-04-08 | 1.38 | HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential HIV-1 escape through identical epitopes |
3QN8 | 2012-02-08 | 1.38 | HIV-1 protease (mutant Q7K L33I L63I) in complex with a novel inhibitor |
4MC1 | 2014-04-02 | 1.39 | HIV protease in complex with SA526P |
3QIH | 2012-02-01 | 1.39 | HIV-1 protease (mutant Q7K L33I L63I) in complex with a novel inhibitor |
3K0N | 2009-12-08 | 1.39 | Room temperature structure of CypA |
3K4V | 2010-06-09 | 1.39 | New crystal form of HIV-1 Protease/Saquinavir structure reveals carbamylation of N-terminal proline |
2XDE | 2010-12-22 | 1.4 | Crystal structure of the complex of PF-3450074 with an engineered HIV capsid N terminal domain |
3QIO | 2011-04-20 | 1.4 | Crystal Structure of HIV-1 RNase H with engineered E. coli loop and N-hydroxy quinazolinedione inhibitor |
3KA2 | 2011-04-27 | 1.4 | Crystal structure of chemically synthesized 203 amino acid 'covalent dimer' [L-Ala;Gly51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.4 A resolution |
5T9Z | 2017-01-25 | 1.4 | Discovery of a Potent Cyclophilin Inhibitor (Compound 6) based on Structural Simplification of Sanglifehrin A |
2AOI | 2006-01-17 | 1.4 | Crystal structure analysis of HIV-1 protease with a substrate analog P1-P6 |
2X2A | 2010-03-23 | 1.4 | Free acetyl-CypA trigonal form |
4FM6 | 2012-10-17 | 1.4 | HIV-1 protease mutant V32I complexed with reaction intermediate |
4DGD | 2012-02-08 | 1.4 | TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant |
2AOD | 2006-01-17 | 1.4 | Crystal structure analysis of HIV-1 protease with a substrate analog P2-NC |
3QAA | 2011-12-21 | 1.4 | HIV-1 wild type protease with a substituted bis-Tetrahydrofuran inhibitor, GRL-044-10A |
3CYW | 2008-05-27 | 1.4 | Effect of Flap Mutations on Structure of HIV-1 Protease and Inhibition by Saquinavir and Darunavir |
1SDV | 2004-05-25 | 1.4 | Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site. |
2QNP | 2008-04-15 | 1.41 | HIV-1 Protease in complex with a iodo decorated pyrrolidine-based inhibitor |
4YUJ | 2015-10-14 | 1.42 | Multiconformer synchrotron model of CypA at 240 K |
2AOH | 2006-01-17 | 1.42 | Crystal structure analysis of HIV-1 Protease mutant V82A with a substrate analog P6-PR |
4YUL | 2015-10-14 | 1.42 | Multiconformer synchrotron model of CypA at 280 K |
5NOY | 2017-07-12 | 1.43 | Structure of cyclophilin A in complex with 3,4-diaminobenzamide |
3VFA | 2012-11-21 | 1.43 | Crystal Structure of HIV-1 Protease Mutant V82A with novel P1'-Ligands GRL-02031 |
5WC7 | 2018-04-18 | 1.43 | CypA Mutant - I97V S99T C115S |
5AH9 | 2015-05-06 | 1.44 | Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II) |
2FNT | 2006-09-05 | 1.44 | Crystal structure of a drug-resistant (V82A) inactive (D25N) HIV-1 protease complexed with AP2V variant of HIV-1 NC-p1 substrate. |
3QP0 | 2012-02-15 | 1.45 | HIV-1 protease (mutant Q7K L33I L63I) in complex with a novel inhibitor |
3NYG | 2011-11-02 | 1.45 | X-ray structure of ester chemical analogue [O-Gly51,O-Gly51']HIV-1 protease complexed with MVT-101 inhibitor |
3UFN | 2012-03-28 | 1.45 | Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Saquinavir |
2F80 | 2006-03-07 | 1.45 | HIV-1 Protease mutant D30N complexed with inhibitor TMC114 |
3TOF | 2012-08-15 | 1.45 | HIV-1 Protease - Epoxydic Inhibitor Complex (pH 6 - Orthorombic Crystal form P212121) |
3ST5 | 2011-08-17 | 1.45 | Crystal structure of wild-type HIV-1 protease with C3-Substituted Hexahydrocyclopentafuranyl Urethane as P2-Ligand, GRL-0489A |
3WNF | 2013-12-25 | 1.45 | Cyclic hexapeptide CKIDNC in complex with HIV-1 integrase |
3O9I | 2011-08-10 | 1.45 | Crystal Structure of wild-type HIV-1 Protease in complex with af61 |
3QBF | 2012-01-18 | 1.45 | HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor |
3PWR | 2011-04-20 | 1.45 | HIV-1 Protease Mutant L76V complexed with Saquinavir |
5NOT | 2017-07-12 | 1.45 | Structure of cyclophilin A in complex with 4-chloropyrimidin-5-amine |
3B7V | 2007-12-18 | 1.46 | HIV-1 protease complexed with gem-diol-amine tetrahedral intermediate NLLTQI |
3PWM | 2011-04-20 | 1.46 | HIV-1 Protease Mutant L76V with Darunavir |
6B3F | 2018-01-03 | 1.46 | Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,5S)-5-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide |
4HEG | 2013-08-21 | 1.46 | Crystal Structure of HIV-1 protease mutants R8Q complexed with inhibitor GRL-0519 |
6O48 | 2019-06-19 | 1.46 | Wild-type HIV-1 protease in complex with a substrate analog CA-p2 |
4N1S | 2015-08-12 | 1.47 | Structure of Cyclophilin A in complex with benzohydrazide. |
6B38 | 2018-01-03 | 1.48 | Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,6R)-6-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide |
5NOW | 2017-07-12 | 1.48 | Structure of cyclophilin A in complex with pyridine-3,4-diamine |
2QNN | 2008-04-15 | 1.48 | HIV-1 protease in complex with a multiple decorated pyrrolidine-based inhibitor |
6DIL | 2018-10-17 | 1.48 | HIV-1 protease with single mutation L76V in complex with tipranavir |
4YUK | 2015-10-14 | 1.48 | Multiconformer synchrotron model of CypA at 260 K |
5TA2 | 2017-01-25 | 1.48 | Discovery of a Potent Cyclophilin Inhibitor (Compound 7) based on Structural Simplification of Sanglifehrin A |
6MCR | 2019-04-24 | 1.48 | X-ray crystal structure of wild type HIV-1 protease in complex with GRL-001 |
4YUG | 2015-10-14 | 1.48 | Multiconformer synchrotron model of CypA at 100 K |
5JFP | 2016-09-21 | 1.49 | HIV-1 wild Type protease with GRL-097-13A (a Adamantane P1-Ligand with bis-THF in P2 and isobutylamine in P1') |
5NOX | 2017-07-12 | 1.49 | Structure of cyclophilin A in complex with 2-chloropyridin-3-amine |
4HDB | 2013-08-14 | 1.49 | Crystal Structure of HIV-1 protease mutants D30N complexed with inhibitor GRL-0519 |
5TA4 | 2017-01-25 | 1.5 | Discovery of a Potent Cyclophilin Inhibitor (Compound 8) based on Structural Simplification of Sanglifehrin A |
5YOJ | 2018-07-11 | 1.5 | Structure of A17 HIV-1 Protease in Complex with Inhibitor KNI-1657 |
4DQB | 2012-03-07 | 1.5 | Crystal Structure of wild-type HIV-1 Protease in Complex with DRV |
3NUJ | 2010-08-25 | 1.5 | Crystal Structure of HIV-1 Protease Mutant I54V with Antiviral Drug Amprenavir |
5AHC | 2015-05-06 | 1.5 | Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II) |
1XL2 | 2005-06-07 | 1.5 | HIV-1 Protease in complex with pyrrolidinmethanamine |
3WNH | 2013-12-25 | 1.5 | Cyclic hexapeptide PKZDNv in complex with HIV-1 integrase |
2WLW | 2009-09-22 | 1.5 | Structure of the N-terminal capsid domain of HIV-2 |
4Q1Y | 2015-02-18 | 1.5 | Mutations Outside the Active Site of HIV-1 Protease Alter Enzyme Structure and Dynamic Ensemble of the Active Site to Confer Drug Resistance |
4NX4 | 2014-02-26 | 1.5 | Re-refinement of CAP-1 HIV-CA complex |
3NWQ | 2011-11-02 | 1.5 | X-ray structure of ester chemical analogue [O-Ile50,O-Ile50']HIV-1 protease complexed with MVT-101 |
5AH6 | 2015-05-06 | 1.5 | Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II) |
4A6C | 2012-05-09 | 1.5 | Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based HIV-1 Protease Inhibitors |
2FGV | 2006-11-07 | 1.5 | X-ray crystal structure of HIV-1 Protease T80N variant in complex with the inhibitor saquinavir used to explore the role of invariant Thr80 in HIV-1 protease structure, function, and viral infectivity. |
5HSV | 2017-08-16 | 1.5 | X-Ray structure of a CypA-Alisporivir complex at 1.5 angstrom resolution |
4N1N | 2015-08-12 | 1.5 | Structure of Cyclophilin A in complex with Benzamide. |
4QJ6 | 2014-10-29 | 1.5 | Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with p1-p6 substrate variant (L449F) |
2PWR | 2008-04-15 | 1.5 | HIV-1 protease in complex with a carbamoyl decorated pyrrolidine-based inhibitor |
3B80 | 2007-12-18 | 1.5 | HIV-1 protease mutant I54V complexed with gem-diol-amine intermediate NLLTQI |
2AVV | 2006-01-24 | 1.5 | Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, and G73S |
6B3G | 2018-01-03 | 1.5 | Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,6S)-6-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide |
6BTA | 2018-04-18 | 1.5 | CypA Mutant - S99T C115S |
4YUM | 2015-10-14 | 1.5 | Multiconformer synchrotron model of CypA at 300 K |
5AHB | 2015-05-06 | 1.5 | Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II) |
4G1Q | 2013-02-06 | 1.51 | Crystal structure of HIV-1 reverse transcriptase (RT) in complex with Rilpivirine (TMC278, Edurant), a non-nucleoside rt-inhibiting drug |
6MCS | 2019-04-24 | 1.52 | X-ray crystal structure of wild type HIV-1 protease in complex with GRL-003 |
5ULT | 2017-05-03 | 1.53 | HIV-1 wild Type protease with GRL-100-13A (a Crown-like Oxotricyclic Core as the P2-Ligand with the sulfonamide isostere as the P2' group) |
4ZLS | 2015-07-15 | 1.53 | HIV-1 wild Type protease with GRL-096-13A (a Boc-derivative P2-Ligand, 3,-5-dimethylbiphenyl P1-Ligand) |
2AOE | 2006-01-17 | 1.54 | crystal structure analysis of HIV-1 protease mutant V82A with a substrate analog CA-P2 |
3ZPT | 2013-11-06 | 1.54 | Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors |
4QJA | 2014-10-29 | 1.54 | Crystal structure of inactive HIV-1 protease in complex with p1-p6 substrate variant (P453L) |
4E43 | 2012-05-30 | 1.54 | HIV protease (PR) dimer with acetate in exo site and peptide in active site |
2O4S | 2006-12-12 | 1.54 | Crystal Structure of HIV-1 Protease (Q7K) in Complex with Lopinavir |
4J54 | 2013-05-15 | 1.55 | Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical isolate PR20 with the potent antiviral inhibitor GRL-0519A |
4CPS | 2014-12-17 | 1.55 | Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol |
3TKW | 2012-04-25 | 1.55 | Crystal structure of HIV protease model precursor/Darunavir complex |
2PQZ | 2008-04-15 | 1.55 | HIV-1 Protease in complex with a pyrrolidine-based inhibitor |
5AH7 | 2015-02-18 | 1.55 | Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II) |
3K0O | 2009-12-08 | 1.55 | Room temperature structure of CypA mutant Ser99Thr |
1K1U | 2002-07-10 | 1.55 | Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance |
1DAZ | 2000-05-03 | 1.55 | Structural and kinetic analysis of drug resistant mutants of HIV-1 protease |
3ZPS | 2013-11-06 | 1.55 | Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors |
3VFB | 2012-11-21 | 1.55 | Crystal Structure of HIV-1 Protease Mutant N88D with novel P1'-Ligands GRL-02031 |
5NMH | 2017-11-15 | 1.55 | HLA A02 presenting SLYNTIATL |
4MC2 | 2014-04-02 | 1.56 | HIV protease in complex with SA525P |
1AWQ | 1998-03-18 | 1.58 | CYPA COMPLEXED WITH HAGPIA (PSEUDO-SYMMETRIC MONOMER) |
2R43 | 2008-09-09 | 1.58 | I50V HIV-1 protease in complex with an amino decorated pyrrolidine-based inhibitor |
1AWR | 1998-03-18 | 1.58 | CYPA COMPLEXED WITH HAGPIA |
4YUN | 2015-10-14 | 1.58 | Multiconformer synchrotron model of CypA at 310 K |
3QRS | 2012-02-22 | 1.59 | HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor |
4U1H | 2015-04-08 | 1.59 | HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential HIV-1 escape through identical epitopes |
4COC | 2014-06-04 | 1.59 | HIV-1 capsid C-terminal domain mutant (Y169L) |
6GJI | 2018-11-07 | 1.6 | Cyclophilin A complexed with the tri-vector ligand 8. |
6B3C | 2018-01-03 | 1.6 | Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,6R)-6-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide |
3EL9 | 2009-09-01 | 1.6 | Crystal structure of atazanavir (ATV) in complex with a multidrug HIV-1 protease (V82T/I84V) |
1YND | 2005-04-05 | 1.6 | Structure of human cyclophilin A in complex with the novel immunosuppressant sanglifehrin A at 1.6A resolution |
4G9D | 2013-03-20 | 1.6 | Crystal Structure of HLA B2705-KK10 |
3EL5 | 2009-09-01 | 1.6 | Crystal structure of nelfinavir (NFV) complexed with a multidrug variant (ACT) (V82T/I84V) of HIV-1 protease |
5NOQ | 2017-07-12 | 1.6 | Structure of cyclophilin A in complex with 3-chloropyridin-2-amine |
3DS0 | 2008-09-02 | 1.6 | HIV-1 capsid C-terminal domain mutant (N183A) in complex with an inhibitor of particle assembly (CAI) |
1EXQ | 2000-11-03 | 1.6 | CRYSTAL STRUCTURE OF THE HIV-1 INTEGRASE CATALYTIC CORE DOMAIN |
3OUB | 2011-03-30 | 1.6 | MDR769 HIV-1 protease complexed with NC/p1 hepta-peptide |
4G8I | 2013-03-20 | 1.6 | Crystal Structure of HLA B2705-KK10-L6M |
3BXS | 2008-03-25 | 1.6 | Crystal Structures Of Highly Constrained Substrate And Hydrolysis Products Bound To HIV-1 Protease. Implications For Catalytic Mechanism |
3HLO | 2011-07-27 | 1.6 | Crystal structure of chemically synthesized 'covalent dimer' [Gly51/D-Ala51']HIV-1 protease |
3BXR | 2008-03-25 | 1.6 | Crystal Structures Of Highly Constrained Substrate And Hydrolysis Products Bound To HIV-1 Protease. Implications For Catalytic Mechanism |
3DS1 | 2008-09-02 | 1.6 | HIV-1 capsid C-terminal domain mutant (E187A) in complex with an inhibitor of particle assembly (CAI) |
3FSM | 2010-01-05 | 1.6 | CRYSTAL STRUCTURE OF A CHEMICALLY SYNTHESIZED 203 AMINO ACID 'COVALENT DIMER' [L-Ala51,D-Ala51'] HIV-1 PROTEASE MOLECULE |
3EKW | 2009-09-01 | 1.6 | Crystal structure of the inhibitor Atazanavir (ATV) in complex with a multi-drug resistance HIV-1 protease variant (L10I/G48V/I54V/V64I/V82A) Refer: FLAP+ in citation. |
3OU4 | 2011-03-30 | 1.6 | MDR769 HIV-1 protease complexed with TF/PR hepta-peptide |
2AOJ | 2006-01-17 | 1.6 | Crystal structure analysis of HIV-1 protease with a substrate analog P6-PR |
2Z4O | 2008-04-22 | 1.6 | Wild Type HIV-1 Protease with potent Antiviral inhibitor GRL-98065 |
2O4K | 2006-12-12 | 1.6 | Crystal Structure of HIV-1 Protease (Q7K) in Complex with Atazanavir |
3JVY | 2009-12-08 | 1.6 | HIV-1 Protease Mutant G86A with DARUNAVIR |
3IAW | 2011-04-27 | 1.61 | Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution |
3QPJ | 2012-02-15 | 1.61 | HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor |
5NOZ | 2017-07-12 | 1.61 | Structure of cyclophilin A in complex with 3,4-diaminobenzohydrazide |
6C8X | 2018-12-05 | 1.61 | Wild-type HIV-1 protease in complex with a phenylboronic acid (P2') analog of darunavir |
6B3H | 2018-01-03 | 1.62 | Crystal Structure of HIV Protease complexed with N-(2-(2-((6R,9S)-2,2-dioxido-2-thia-1,7-diazabicyclo[4.3.1]decan-9-yl)ethyl)-3-fluorophenyl)-3,3-bis(4-fluorophenyl)propanamide |
5DGW | 2015-10-28 | 1.62 | Crystal Structure of HIV-1 Protease Inhibitor GRL-105-11A Containing Substituted fused-Tetrahydropyranyl Tetrahydrofuran as P2-Ligand |
3QRO | 2012-02-22 | 1.62 | HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor |
6B36 | 2018-01-03 | 1.63 | Crystal Structure of HIV Protease complexed with (S)-N-(3-fluoro-2-(2-(1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide |
2CPL | 1993-10-31 | 1.63 | SIMILARITIES AND DIFFERENCES BETWEEN HUMAN CYCLOPHILIN A AND OTHER BETA-BARREL STRUCTURES. STRUCTURAL REFINEMENT AT 1.63 ANGSTROMS RESOLUTION |
3UF3 | 2012-03-28 | 1.63 | Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical isolate PR20 |
2CYH | 1996-07-11 | 1.64 | CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE ALA-PRO |
4IPY | 2013-10-16 | 1.64 | HIV capsid C-terminal domain |
3CKT | 2009-03-24 | 1.65 | HIV-1 protease in complex with a dimethylallyl decorated pyrrolidine based inhibitor (orthorombic space group) |
1ZPK | 2006-04-25 | 1.65 | Crystal structure of the complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2 |
2ZGA | 2009-02-03 | 1.65 | HIV-1 protease in complex with a dimethylallyl decorated pyrrolidine based inhibitor (hexagonal space group) |
5UFZ | 2018-01-10 | 1.65 | HIV-1 Protease complexed with Inhibitor: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2S)-1-(1-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}cyclopropyl)-1-hydroxy-3-phenylpropan-2-yl]carbamate |
2XXM | 2011-10-12 | 1.65 | Crystal structure of the HIV-1 capsid protein C-terminal domain in complex with a camelid VHH and the CAI peptide. |
3O9G | 2011-08-10 | 1.65 | Crystal Structure of wild-type HIV-1 Protease in complex with af53 |
4CF8 | 2013-12-11 | 1.65 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
3OXX | 2011-09-28 | 1.65 | Crystal Structure of HIV-1 I50V, A71V Protease in Complex with the Protease Inhibitor Atazanavir |
2NPH | 2006-12-19 | 1.65 | Crystal structure of HIV1 protease in situ product complex |
1W8M | 2004-09-30 | 1.65 | Enzymatic and Structural Characterisation of Non Peptide Ligand Cyclophilin Complexes |
3KT2 | 2010-02-16 | 1.65 | Crystal Structure of N88D mutant HIV-1 Protease |
4N1Q | 2015-08-12 | 1.65 | Structure of Cyclophilin A in complex with cyclohexanecarboxamide. |
3K0P | 2009-12-08 | 1.65 | Cryogenic structure of CypA mutant Ser99Thr |
4OBK | 2014-11-26 | 1.65 | Crystal structure of inactive HIV-1 protease in complex with the P1-P6 substrate variant (L449F/S451N) |
5KRT | 2016-09-28 | 1.65 | HIV-1 Integrase Catalytic Core Domain (CCD) in Complex with a Fragment-Derived Allosteric Inhibitor |
3KDB | 2010-03-02 | 1.66 | Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10006 |
5NMK | 2017-11-15 | 1.66 | HLA A02 presenting SLFNTIAVL |
6BZ2 | 2018-02-28 | 1.67 | Crystal structure of wild-type HIV-1 protease with a novel HIV-1 inhibitor GRL-14213A of 6-5-5-ring fused crown-like tetrahydropyranofuran as the P2-ligand, a cyclopropylaminobenzothiazole as the P2'-ligand and 3,5-difluorophenylmethyl as the P1-ligand |
4QJ7 | 2014-10-29 | 1.67 | Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with p1-p6 substrate variant (R452S) |
4IPZ | 2013-11-06 | 1.67 | SmBz bound to Cyclophilin A |
4OBF | 2014-11-26 | 1.68 | Crystal Structure of Nelfinavir-Resistant, Inactive HIV-1 Protease Variant (D30N/N88D) in Complex with the p1-p6 substrate variant (S451N) |
4EPJ | 2012-06-06 | 1.69 | Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate p2-NC |
6GJR | 2018-11-07 | 1.69 | Cyclophilin A complexed with tri-vector ligand 9. |
2WHH | 2009-12-01 | 1.69 | HIV-1 protease tethered dimer Q-product complex along with nucleophilic water molecule |
1DIF | 1996-03-08 | 1.7 | HIV-1 PROTEASE IN COMPLEX WITH A DIFLUOROKETONE CONTAINING INHIBITOR A79285 |
3ZSR | 2012-07-11 | 1.7 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
5KV1 | 2016-08-10 | 1.7 | Human cyclophilin A at 278K, Data set 3 |
5KUV | 2016-08-10 | 1.7 | Human cyclophilin A at 100K, Data set 8 |
2BBB | 2005-11-15 | 1.7 | Structure of HIV1 protease and hh1_173_3a complex. |
2WKZ | 2009-12-15 | 1.7 | HIV-1 Protease Inhibitors Containing a Tertiary Alcohol in the Transition-State Mimic with Improved Cell-Based Antiviral Activity |
1K2B | 2002-07-10 | 1.7 | Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance |
3QIN | 2011-04-20 | 1.7 | Crystal Structure of HIV-1 RNase H p15 with engineered E. coli loop and pyrimidinol carboxylic acid inhibitor |
5KV0 | 2016-08-31 | 1.7 | Human cyclophilin A at 278K, Data set 2 |
3I7E | 2009-09-29 | 1.7 | Co-crystal structure of HIV-1 protease bound to a mutant resistant inhibitor UIC-98038 |
5KUL | 2016-09-07 | 1.7 | Human cyclophilin A at 100K, Data set 1 |
5KV3 | 2016-08-10 | 1.7 | Human cyclophilin A at 278K, Data set 5 |
1B9F | 1999-07-19 | 1.7 | MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY |
5KRS | 2016-09-28 | 1.7 | HIV-1 Integrase Catalytic Core Domain in Complex with an Allosteric Inhibitor, 3-(1H-pyrrol-1-yl)-2-thiophenecarboxylic acid |
5XOS | 2017-06-14 | 1.7 | Crystal structure of HLA-B35 in complex with a pepetide antigen |
5KV4 | 2016-08-10 | 1.7 | Human cyclophilin A at 278K, Data set 6 |
5KV6 | 2016-08-10 | 1.7 | Human cyclophilin A at 278K, Data set 8 |
5KUS | 2016-08-10 | 1.7 | Human cyclophilin A at 100K, Data set 6 |
4CIE | 2014-01-08 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4CEZ | 2013-11-27 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
3AVG | 2012-01-18 | 1.7 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
3OTS | 2011-03-30 | 1.7 | MDR769 HIV-1 protease complexed with MA/CA hepta-peptide |
4CEQ | 2013-11-20 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4E91 | 2012-04-25 | 1.7 | Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BD3 |
5KUW | 2016-08-10 | 1.7 | Human cyclophilin A at 100K, Data set 9 |
5KV7 | 2016-08-31 | 1.7 | Human cyclophilin A at 278K, Data set 9 |
5KV2 | 2016-08-10 | 1.7 | Human cyclophilin A at 278K, Data set 4 |
4CPT | 2014-12-17 | 1.7 | Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol |
2BUO | 2005-07-21 | 1.7 | HIV-1 capsid C-terminal domain in complex with an inhibitor of particle assembly |
4CJ3 | 2014-01-08 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
3ZT2 | 2012-07-11 | 1.7 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
3WNE | 2013-12-25 | 1.7 | Cyclic hexapeptide PKIDNG in complex with HIV-1 integrase |
1HYV | 2001-04-04 | 1.7 | HIV INTEGRASE CORE DOMAIN COMPLEXED WITH TETRAPHENYL ARSONIUM |
4DGB | 2012-02-08 | 1.7 | TRIMCyp cyclophilin domain from Macaca mulatta: HIV-2 CA cyclophilin-binding loop complex |
4U7Q | 2015-03-25 | 1.7 | Structure of wild-type HIV protease in complex with photosensitive inhibitor PDI-6 |
4CGF | 2013-12-04 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
5KUO | 2016-08-31 | 1.7 | Human cyclophilin A at 100K, Data set 3 |
5JPA | 2016-08-10 | 1.7 | Hexameric HIV-1 CA H12Y mutant |
3AVA | 2012-01-18 | 1.7 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
4CHY | 2013-12-18 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
3OUA | 2011-03-30 | 1.7 | MDR769 HIV-1 protease complexed with p1/p6 hepta-peptide |
3AVJ | 2012-01-18 | 1.7 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
4CER | 2013-11-20 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4OVL | 2014-03-05 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
5KUZ | 2016-08-10 | 1.7 | Human cyclophilin A at 278K, Data set 1 |
3NLS | 2011-09-07 | 1.7 | Crystal Structure of HIV-1 Protease in Complex with KNI-10772 |
1M9X | 2003-05-27 | 1.7 | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,A88M,G89A Complex. |
3IXO | 2010-03-02 | 1.7 | Crystal Structure of uncomplexed HIV_1 Protease Subtype A |
3I8W | 2009-12-01 | 1.7 | Crystal structure of a metallacarborane inhibitor bound to HIV protease |
3O9H | 2011-08-10 | 1.7 | Crystal Structure of wild-type HIV-1 Protease in complex with kd26 |
3AVI | 2012-02-15 | 1.7 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
3ZSQ | 2012-07-11 | 1.7 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
5JFU | 2016-09-21 | 1.7 | HIV-1 wild Type protease with GRL-007-14A (a Adamantane P1-Ligand with bis-THF in P2 and benzylamine in P1') |
5KUN | 2016-08-10 | 1.7 | Human cyclophilin A at 100K, Data set 2 |
4CIG | 2014-01-08 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4CJQ | 2014-01-08 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4CJU | 2014-01-22 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
5KUR | 2016-09-07 | 1.7 | Human cyclophilin A at 100K, Data set 5 |
4CHO | 2013-12-11 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4CEF | 2013-11-20 | 1.7 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
3EL1 | 2009-09-01 | 1.7 | Crystal Structure of wild-type HIV protease in complex with the inhibitor, Atazanavir |
6GJN | 2018-11-07 | 1.7 | Cyclophilin A complexed with tri-vector ligand 15. |
5KV5 | 2016-08-10 | 1.7 | Human cyclophilin A at 278K, Data set 7 |
1B9D | 1999-07-19 | 1.7 | MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY |
4AH9 | 2012-12-19 | 1.7 | Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification |
5KUQ | 2016-08-10 | 1.7 | Human cyclophilin A at 100K, Data set 4 |
1A8O | 1998-10-14 | 1.7 | HIV CAPSID C-TERMINAL DOMAIN |
5KUU | 2016-08-31 | 1.7 | Human cyclophilin A at 100K, Data set 7 |
4F75 | 2013-05-15 | 1.7 | Crystal Structure of active HIV-1 Protease in Complex with the N terminal product of the substrate RH-IN |
1FFI | 2001-06-01 | 1.7 | STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES |
3OU3 | 2011-03-30 | 1.7 | MDR769 HIV-1 protease complexed with PR/RT hepta-peptide |
4EQ0 | 2012-06-06 | 1.7 | Crystal Structure of inactive single chain variant of HIV-1 Protease in Complex with the substrate p2-NC |
3O9F | 2011-08-10 | 1.7 | Crystal Structure of wild-type HIV-1 Protease in complex with kd27 |
3AVF | 2012-01-18 | 1.7 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
1W8V | 2004-09-30 | 1.7 | Enzymatic and structural characterization of non peptide ligand cyclophilin complexes |
4CPW | 2014-12-17 | 1.7 | Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol |
3AV9 | 2012-01-18 | 1.7 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
3HBO | 2010-05-26 | 1.71 | Crystal structure of chemically synthesized [D-Ala51/51']HIV-1 protease |
4CJT | 2014-01-08 | 1.71 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4QAG | 2014-06-04 | 1.71 | Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNASE H domain of HIV-1 reverse transcriptase |
3OQD | 2011-04-06 | 1.71 | Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants |
3OQ7 | 2011-04-06 | 1.71 | Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants |
1M9E | 2003-05-27 | 1.72 | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A Complex. |
3NDT | 2011-07-20 | 1.72 | HIV-1 Protease Saquinavir:Ritonavir 1:1 complex structure |
1M9F | 2003-05-27 | 1.73 | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,A88M Complex. |
3QRM | 2012-02-22 | 1.73 | HIV-1 protease (mutant Q7K L33I L63I) in complex with a three-armed pyrrolidine-based inhibitor |
1XL5 | 2005-06-07 | 1.73 | HIV-1 Protease in complex with amidhyroxysulfone |
4CEC | 2013-11-20 | 1.75 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4CK1 | 2014-01-22 | 1.75 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
3EKV | 2009-09-01 | 1.75 | Crystal structure of the wild type HIV-1 protease with the inhibitor, Amprenavir |
3OXV | 2011-09-28 | 1.75 | Crystal Structure of HIV-1 I50V, A71 Protease in Complex with the protease inhibitor amprenavir. |
1MTR | 1996-08-01 | 1.75 | HIV-1 PROTEASE COMPLEXED WITH A CYCLIC PHE-ILE-VAL PEPTIDOMIMETIC INHIBITOR |
4CGG | 2013-12-04 | 1.75 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4CED | 2013-11-20 | 1.75 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4I8Z | 2013-07-24 | 1.75 | Crystal structure of wild type HIV-1 protease in complex with non-peptidic inhibitor, GRL008 |
3OTY | 2011-03-30 | 1.75 | MDR769 HIV-1 protease complexed with RT/RH hepta-peptide |
4OBJ | 2014-11-26 | 1.75 | Crystal Structure of Inactive HIV-1 Protease in Complex with the p1-p6 substrate variant (S451N) |
4CEB | 2013-11-20 | 1.75 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
3ZT1 | 2012-07-11 | 1.75 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
5HRN | 2016-12-14 | 1.75 | HIV Integrase Catalytic Domain containing F185K mutation complexed with GSK0002 |
3ZSO | 2012-07-11 | 1.75 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based design |
1B6L | 2000-01-07 | 1.75 | HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 4 |
4AHS | 2012-12-19 | 1.75 | Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification |
3AVK | 2012-01-18 | 1.75 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
2UXZ | 2008-05-20 | 1.75 | Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary- Alcohol-Containing Transition-State Mimic |
3ZSV | 2012-07-11 | 1.75 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
6DJ5 | 2018-10-17 | 1.75 | HIV-1 protease with mutation L76V in complex with GRL-0519 (tris-tetrahydrofuran as P2 ligand) |
3BHE | 2008-12-09 | 1.75 | HIV-1 protease in complex with a three armed pyrrolidine derivative |
3WNG | 2013-12-25 | 1.75 | Cyclic hexapeptide PKIDNp in complex with HIV-1 integrase |
4YUP | 2015-10-14 | 1.75 | Multiconformer fixed-target X-ray free electron (XFEL) model of CypA at 273 K |
4CJK | 2014-01-08 | 1.75 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
1D4L | 2000-10-11 | 1.75 | HIV-1 PROTEASE COMPLEXED WITH A MACROCYCLIC PEPTIDOMIMETIC INHIBITOR |
4N1O | 2015-08-12 | 1.75 | Structure of Cyclophilin A in complex with Saccharin. |
3LZU | 2010-08-11 | 1.76 | Crystal Structure of a Nelfinavir Resistant HIV-1 CRF01_AE Protease variant (N88S) in Complex with the Protease Inhibitor Darunavir. |
4CGH | 2013-12-04 | 1.76 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
1MIK | 1996-03-08 | 1.76 | THE ROLE OF WATER MOLECULES IN THE STRUCTURE-BASED DESIGN OF (5-HYDROXYNORVALINE)-2-CYCLOSPORIN: SYNTHESIS, BIOLOGICAL ACTIVITY, AND CRYSTALLOGRAPHIC ANALYSIS WITH CYCLOPHILIN A |
2UY0 | 2008-05-20 | 1.76 | Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary- Alcohol-Containing Transition-State Mimic |
5JL4 | 2017-10-04 | 1.76 | Inhibitor resistant mutant catalytic core domain of HIV-1 Integrase |
3OY4 | 2011-02-09 | 1.76 | Crystal Structure of HIV-1 L76V Protease in Complex with the Protease Inhibitor Darunavir. |
5YRS | 2018-03-07 | 1.76 | X-ray Snapshot of HIV-1 Protease in Action: Observation of Tetrahedral Intermediate and Its SIHB with Catalytic Aspartate |
4CJL | 2014-01-08 | 1.77 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4U0C | 2014-11-12 | 1.77 | Hexameric HIV-1 CA in complex with Nup153 peptide, P6 crystal form |
3KFP | 2010-02-23 | 1.77 | HIV Protease (PR) with inhibitor TL-3 bound, and DMSOs in exo site |
3KFN | 2010-02-23 | 1.77 | HIV Protease (PR) with inhibitor TL-3 and fragment hit 4D9 by soaking |
3AVC | 2012-01-18 | 1.77 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
1FEJ | 2001-06-01 | 1.78 | STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES |
2PWC | 2008-04-15 | 1.78 | HIV-1 protease in complex with a amino decorated pyrrolidine-based inhibitor |
4OBG | 2014-11-26 | 1.78 | Crystal Structure of Nelfinavir-Resistant, Inactive HIV-1 Protease (D30N/N88D) in Complex with the p1-p6 substrate. |
4DQH | 2012-03-07 | 1.79 | Crystal Structure of (R14C/E65C) HIV-1 Protease in complex with DRV |
4CK3 | 2014-01-22 | 1.79 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4EJK | 2013-05-01 | 1.79 | HIV Protease (PR) dimer in closed form with pepstatin in active site and fragment 1F1-N in the outside/top of flap |
1EC0 | 2002-06-26 | 1.79 | HIV-1 protease in complex with the inhibitor bea403 |
4GB2 | 2013-07-31 | 1.79 | HIV-1 protease (mutant Q7K L33I L63I) in complex with a bicyclic pyrrolidine inhibitor |
4Q5M | 2015-04-08 | 1.79 | D30N tethered HIV-1 protease dimer/saquinavir complex |
1HVL | 1994-04-30 | 1.8 | INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE |
1PRO | 1996-08-17 | 1.8 | HIV-1 PROTEASE DIMER COMPLEXED WITH A-98881 |
1HVR | 1995-01-26 | 1.8 | RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS |
3ZCM | 2012-12-05 | 1.8 | Small molecule inhibitors of the LEDGF site of HIV integrase identified by fragment screening and structure based design. |
4CP7 | 2014-12-10 | 1.8 | Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol |
1W5W | 2004-12-22 | 1.8 | HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor |
3KDD | 2010-03-02 | 1.8 | Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10265 |
5KAO | 2016-08-31 | 1.8 | Crystal structure of wild type HIV-1 protease in complex with GRL-10413 |
2QI4 | 2008-04-22 | 1.8 | Crystal structure of protease inhibitor, MIT-2-AD93 in complex with wild type HIV-1 protease |
1HWR | 1999-03-23 | 1.8 | MOLECULAR RECOGNITION OF CYCLIC UREA HIV PROTEASE INHIBITORS |
4A6B | 2012-05-09 | 1.8 | Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based HIV-1 Protease Inhibitors |
3KT5 | 2010-02-16 | 1.8 | Crystal Structure of N88S mutant HIV-1 Protease |
4CEE | 2013-11-27 | 1.8 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
1HVK | 1994-04-30 | 1.8 | INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE |
1W5V | 2004-12-01 | 1.8 | HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor |
4N1R | 2015-08-12 | 1.8 | Structure of Cyclophilin A in complex with benzenesulfonohydrazide. |
6AOC | 2018-08-08 | 1.8 | Crystal Structure of an N-Hydroxythienopyrimidine-2,4-dione RNase H Active Site Inhibitor with Multiple Binding Modes to HIV Reverse Transcriptase |
2FXE | 2007-02-20 | 1.8 | X-ray crystal structure of HIV-1 protease CRM mutant complexed with atazanavir (BMS-232632) |
2R3T | 2008-09-02 | 1.8 | I50V HIV-1 protease mutant in complex with a carbamoyl decorated pyrrolidine-based inhibitor |
3GI5 | 2010-03-09 | 1.8 | Crystal structure of protease inhibitor, KB62 in complex with wild type HIV-1 protease |
3OUD | 2011-03-30 | 1.8 | MDR769 HIV-1 protease complexed with CA/p2 hepta-peptide |
4ICL | 2013-02-06 | 1.8 | HIV-1 reverse transcriptase with bound fragment at the incoming dNTP binding site |
1CWK | 1998-07-15 | 1.8 | HUMAN CYCLOPHILIN A COMPLEXED WITH 1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORIN |
3GGU | 2009-08-11 | 1.8 | HIV PR drug resistant patient's variant in complex with darunavir |
3ZPU | 2013-11-06 | 1.8 | Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors |
1HVH | 1998-12-30 | 1.8 | NONPEPTIDE CYCLIC CYANOGUANIDINES AS HIV PROTEASE INHIBITORS |
1BCK | 1998-09-16 | 1.8 | HUMAN CYCLOPHILIN A COMPLEXED WITH 2-THR CYCLOSPORIN |
1EC3 | 2002-06-26 | 1.8 | HIV-1 protease in complex with the inhibitor MSA367 |
1QBR | 1997-10-15 | 1.8 | HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY |
4J5J | 2013-05-15 | 1.8 | Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Amprenavir |
2XGY | 2010-09-22 | 1.8 | Complex of Rabbit Endogenous Lentivirus (RELIK)Capsid with Cyclophilin A |
4AHV | 2012-12-19 | 1.8 | Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification |
4LH4 | 2013-12-25 | 1.8 | Dual inhibition of HIV-1 replication by Integrase-LEDGF allosteric inhibitors is predominant at post-integration stage during virus production rather than at integration |
4CIF | 2014-01-08 | 1.8 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4K4Q | 2013-09-18 | 1.8 | TL-3 inhibited Trp6Ala HIV Protease with 3-bromo-2,6-dimethoxybenzoic acid bound in flap site |
3OU1 | 2011-03-30 | 1.8 | MDR769 HIV-1 protease complexed with RH/IN hepta-peptide |
2XYF | 2011-12-07 | 1.8 | HIV-1 Inhibitors with a Tertiary-Alcohol-containing Transition-State Mimic and various P2 and P1 prime Substituents |
4CEA | 2013-11-20 | 1.8 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4CPR | 2014-12-17 | 1.8 | Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol |
3NXN | 2011-11-02 | 1.8 | X-ray structure of ester chemical analogue 'covalent dimer' [Ile50,O-Ile50']HIV-1 protease complexed with KVS-1 inhibitor |
4CJ4 | 2014-01-08 | 1.8 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4EQJ | 2012-06-06 | 1.8 | Crystal Structure of inactive single chain variant of HIV-1 Protease in Complex with the substrate RT-RH |
3NF7 | 2011-04-27 | 1.8 | Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design |
3GI0 | 2011-08-10 | 1.8 | Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [l-ala51,d-ala51'] hiv-1 protease molecule complexed with jg-365 inhibitor |
3AO2 | 2011-03-16 | 1.8 | Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase |
4CJS | 2014-01-08 | 1.8 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
1BWB | 1998-09-30 | 1.8 | HIV-1 PROTEASE (V82F/I84V) DOUBLE MUTANT COMPLEXED WITH SD146 OF DUPONT PHARMACEUTICALS |
4CHZ | 2013-12-18 | 1.8 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
3KF0 | 2010-02-23 | 1.8 | HIV Protease with fragment 4D9 bound |
4E92 | 2012-04-25 | 1.8 | Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BM4 |
4AHT | 2012-12-19 | 1.8 | Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification |
3JVW | 2009-12-08 | 1.8 | HIV-1 Protease Mutant G86A with symmetric inhibitor DMP323 |
1FGL | 1997-04-01 | 1.8 | Cyclophilin A complexed with a fragment of HIV-1 GAG protein |
1G35 | 2001-06-06 | 1.8 | CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR, AHA024 |
4K4R | 2013-09-18 | 1.8 | TL-3 inhibited Trp6Ala HIV Protease with 1-bromo-2-napthoic acid bound in exosite |
1FG6 | 2001-06-01 | 1.8 | STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES |
3ZSW | 2012-07-11 | 1.8 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
3BGC | 2008-09-02 | 1.8 | HIV-1 protease in complex with a benzyl decorated oligoamine |
3KFS | 2010-02-23 | 1.8 | HIV Protease (PR) dimer with inhibitor TL-3 bound and fragment 2F4 in the outside/top of flap |
1SP5 | 2005-07-19 | 1.8 | Crystal structure of HIV-1 protease complexed with a product of autoproteolysis |
3HDK | 2010-04-28 | 1.8 | Crystal structure of chemically synthesized [Aib51/51']HIV-1 protease |
1QBS | 1997-10-15 | 1.8 | HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY |
1QBU | 1997-10-15 | 1.8 | HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY |
3EKY | 2009-09-01 | 1.8 | Crystal Structure of wild-type HIV protease in complex with the inhibitor, Atazanavir |
1W8L | 2004-09-30 | 1.8 | Enzymatic and structural characterization of non peptide ligand cyclophilin complexes |
1CWL | 1998-07-15 | 1.8 | HUMAN CYCLOPHILIN A COMPLEXED WITH 4 4-HYDROXY-MELEU CYCLOSPORIN |
1HXW | 1998-02-04 | 1.8 | HIV-1 PROTEASE DIMER COMPLEXED WITH A-84538 |
1CWJ | 1998-08-26 | 1.8 | HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL 3-S-METHYL-SARCOSINE CYCLOSPORIN |
5NOR | 2017-07-12 | 1.8 | Structure of cyclophilin A in complex with 3-methylpyridin-2-amine |
3JW2 | 2009-12-08 | 1.8 | HIV-1 Protease Mutant G86S with DARUNAVIR |
4CJR | 2014-01-08 | 1.8 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
5VCK | 2018-04-18 | 1.8 | HIV Protease (PR) with TL-3 in the active site and (Z)-N-(thiazol-2-yl)-N'-tosylcarbamimidate in the exosite |
2ZD1 | 2008-02-12 | 1.8 | Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with TMC278 (Rilpivirine), A Non-nucleoside RT Inhibitor |
1D4I | 2002-06-26 | 1.81 | HIV-1 protease in complex with the inhibitor BEA425 |
5HRP | 2016-12-14 | 1.81 | HIV Integrase Catalytic Domain containing F185K + A124T mutations complexed with GSK0002 |
1D4H | 2002-06-26 | 1.81 | HIV-1 Protease in complex with the inhibitor BEA435 |
4EP3 | 2012-06-06 | 1.81 | Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate CA-p2 |
1EBW | 2002-06-26 | 1.81 | HIV-1 protease in complex with the inhibitor BEA322 |
2R38 | 2008-09-02 | 1.81 | I84V HIV-1 protease mutant in complex with a carbamoyl decorated pyrrolidine-based inhibitor |
1D4J | 2002-06-26 | 1.81 | HIV-1 protease in complex with the inhibitor MSL370 |
3BC4 | 2008-09-02 | 1.82 | I84V HIV-1 protease in complex with a pyrrolidine diester |
4CPU | 2014-12-17 | 1.82 | Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol |
4OJR | 2014-06-11 | 1.82 | Crystal Structure of the HIV-1 Integrase catalytic domain with GSK1264 |
4QJ9 | 2014-10-29 | 1.83 | Crystal structure of inactive HIV-1 protease in complex with p1-p6 substrate variant (R452S) |
1IIQ | 2002-04-12 | 1.83 | CRYSTAL STRUCTURE OF HIV-1 PROTEASE COMPLEXED WITH A HYDROXYETHYLAMINE PEPTIDOMIMETIC INHIBITOR |
3GI6 | 2010-03-09 | 1.84 | Crystal structure of protease inhibitor, AD78 in complex with wild type HIV-1 protease |
5TC2 | 2018-04-04 | 1.84 | C-terminal domain of HIV-1 integrase, crystal structure |
3GI4 | 2010-03-09 | 1.85 | Crystal structure of protease inhibitor, KB60 in complex with wild type HIV-1 protease |
1FF0 | 2001-06-01 | 1.85 | STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES. |
1Z1H | 2005-03-22 | 1.85 | HIV-1 protease complexed with macrocyclic peptidomimetic inhibitor 3 |
3DLK | 2008-10-07 | 1.85 | Crystal Structure of an engineered form of the HIV-1 Reverse Transcriptase, RT69A |
2QI7 | 2008-04-22 | 1.85 | Crystal structure of protease inhibitor, MIT-2-AD86 in complex with wild type HIV-1 protease |
4COP | 2014-06-04 | 1.85 | HIV-1 capsid C-terminal domain mutant (Y169S) |
6D0D | 2019-05-01 | 1.85 | X-ray crystal structure of wild type HIV-1 protease in complex with GRL-087-13 |
2QHY | 2008-04-22 | 1.85 | Crystal Structure of protease inhibitor, MIT-1-AC86 in complex with wild type HIV-1 protease |
4CF0 | 2013-11-20 | 1.85 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
2QHZ | 2008-04-22 | 1.85 | Crystal structure of protease inhibitor, MIT-1-AC87 in complex with wild type HIV-1 protease |
1B6J | 2000-01-07 | 1.85 | HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 1 |
2PYN | 2008-02-26 | 1.85 | HIV-1 PR mutant in complex with nelfinavir |
4CPX | 2014-12-17 | 1.85 | Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol |
4CK2 | 2014-01-22 | 1.85 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
1Z1R | 2005-03-22 | 1.85 | HIV-1 protease complexed with Macrocyclic peptidomimetic inhibitor 2 |
1D4K | 2000-10-11 | 1.85 | HIV-1 PROTEASE COMPLEXED WITH A MACROCYCLIC PEPTIDOMIMETIC INHIBITOR |
2QI5 | 2008-04-22 | 1.85 | Crystal structure of protease inhibitor, MIT-2-KC08 in complex with wild type HIV-1 protease |
4KFB | 2013-05-15 | 1.85 | HIV-1 reverse transcriptase with bound fragment at NNRTI adjacent site |
3NU9 | 2010-08-25 | 1.85 | Crystal Structure of HIV-1 Protease Mutant I84V with Antiviral Drug Amprenavir |
4OBH | 2014-11-26 | 1.85 | Crystal Structure of Inactive HIV-1 Protease in Complex with the p1-p6 substrate variant (L449F) |
4CES | 2013-11-20 | 1.85 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
2QI6 | 2008-04-22 | 1.85 | Crystal structure of protease inhibitor, MIT-2-KB98 in complex with wild type HIV-1 protease |
1B6M | 2000-01-07 | 1.85 | HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 6 |
4Q1W | 2015-02-18 | 1.85 | Mutations Outside the Active Site of HIV-1 Protease Alter Enzyme Structure and Dynamic Ensemble of the Active Site to Confer Drug Resistance |
2FNS | 2006-09-05 | 1.85 | Crystal structure of wild-type inactive (D25N) HIV-1 protease complexed with wild-type HIV-1 NC-p1 substrate. |
4F76 | 2013-05-15 | 1.85 | Crystal Structure of the active HIV-1 Protease in Complex with the products of p1-p6 substrate |
3AVB | 2012-01-18 | 1.85 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
1B6K | 2000-01-07 | 1.85 | HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 5 |
1FG8 | 2001-06-01 | 1.85 | STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES |
3MXE | 2010-11-10 | 1.85 | Crystal structure of HIV-1 protease inhibitor, KC32 complexed with wild-type protease |
1CWH | 1998-07-15 | 1.86 | HUMAN CYCLOPHILIN A COMPLEXED WITH 3-D-SER CYCLOSPORIN |
1CWF | 1998-07-15 | 1.86 | HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL CYCLOSPORIN |
1CWO | 1998-08-12 | 1.86 | HUMAN CYCLOPHILIN A COMPLEXED WITH THR2, LEU5, D-HIV8, LEU10 CYCLOSPORIN |
1CWC | 1996-01-29 | 1.86 | IMPROVED BINDING AFFINITY FOR CYCLOPHILIN A BY A CYCLOSPORIN DERIVATIVE SINGLY MODIFIED AT ITS EFFECTOR DOMAIN |
5HRS | 2016-12-14 | 1.86 | HIV Integrase Catalytic Domain containing F185K + A124N + T125A mutations complexed with GSK0002 |
4ID1 | 2013-05-01 | 1.87 | HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor |
5HRR | 2016-12-14 | 1.88 | HIV Integrase Catalytic Domain containing F185K + A124N + T125S mutations complexed with GSK0002 |
3AVH | 2012-01-18 | 1.88 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
3AVM | 2012-01-18 | 1.88 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
1DW6 | 2000-07-26 | 1.88 | Structural and kinetic analysis of drug resistant mutants of HIV-1 protease |
3AVL | 2012-01-18 | 1.88 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
2XV6 | 2011-10-12 | 1.89 | Crystal structure of the HIV-1 capsid protein C-terminal domain (146- 220) in complex with a camelid VHH. |
4F73 | 2013-05-15 | 1.9 | Crystal Structure of active HIV-1 Protease in Complex with the N terminal product of CA-p2 cleavage site |
2BPV | 1999-02-23 | 1.9 | HIV-1 protease-inhibitor complex |
2ZYE | 2009-03-24 | 1.9 | Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by Neutron Crystallography |
1HPV | 1995-03-31 | 1.9 | CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH VX-478, A POTENT AND ORALLY BIOAVAILABLE INHIBITOR OF THE ENZYME |
2PWM | 2007-09-25 | 1.9 | Crystal Structure of HIV-1 CA146 A92E real cell |
3R4B | 2011-09-21 | 1.9 | Crystal Structure of Wild-type HIV-1 Protease in Complex With TMC310911 |
4DQF | 2012-03-07 | 1.9 | Crystal Structure of (G16A/L38A) HIV-1 Protease in Complex with DRV |
4CEO | 2013-11-20 | 1.9 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
1G6L | 2000-11-15 | 1.9 | 1.9A CRYSTAL STRUCTURE OF TETHERED HIV-1 PROTEASE |
1MT7 | 2003-01-07 | 1.9 | Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy |
4OBD | 2014-11-26 | 1.9 | Crystal Structure of Nelfinavir-Resistant, Inactive HIV-1 Protease (D30N/N88D) in Complex with the p1-p6 substrate variant (L449F/S451N) |
1MES | 1998-04-15 | 1.9 | HIV-1 MUTANT (I84V) PROTEASE COMPLEXED WITH DMP323 |
4DGA | 2012-02-08 | 1.9 | TRIMCyp cyclophilin domain from Macaca mulatta: HIV-1 CA(O-loop) complex |
2GON | 2006-09-26 | 1.9 | Xray Structure of Gag133-278 |
1MEU | 1998-04-15 | 1.9 | HIV-1 MUTANT (V82F, I84V) PROTEASE COMPLEXED WITH DMP323 |
4G9F | 2013-03-20 | 1.9 | Crystal Structure of C12C TCR-HLAB2705-KK10-L6M |
1FGC | 2001-06-01 | 1.9 | STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES |
1SGU | 2004-10-05 | 1.9 | Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease |
2WL0 | 2009-12-15 | 1.9 | HIV-1 Protease Inhibitors Containing a Tertiary Alcohol in the Transition-State Mimic with Improved Cell-Based Antiviral Activity |
3BGB | 2008-09-02 | 1.9 | HIV-1 protease in complex with a isobutyl decorated oligoamine |
4CHP | 2013-12-11 | 1.9 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4CFC | 2013-11-27 | 1.9 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
2BPY | 1999-02-23 | 1.9 | HIV-1 protease-inhibitor complex |
3MGE | 2010-07-21 | 1.9 | X-ray Structure of Hexameric HIV-1 CA |
4CJF | 2014-01-08 | 1.9 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
2PYM | 2008-02-26 | 1.9 | HIV-1 PR mutant in complex with nelfinavir |
4Q1X | 2015-02-18 | 1.9 | Mutations Outside the Active Site of HIV-1 Protease Alter Enzyme Structure and Dynamic Ensemble of the Active Site to Confer Drug Resistance |
1BWA | 1998-10-30 | 1.9 | HIV-1 PROTEASE (V82F/I84V) DOUBLE MUTANT COMPLEXED WITH XV638 OF DUPONT PHARMACEUTICALS |
6ES8 | 2018-08-15 | 1.9 | HIV capsid hexamer with IP6 ligand |
4N1P | 2015-08-12 | 1.9 | Structure of Cyclophilin A in complex with Picolinamide. |
4NYF | 2014-06-25 | 1.9 | HIV integrase in complex with inhibitor |
6BJ3 | 2018-07-25 | 1.9 | TCR55 in complex with HIV(Pol448-456)/HLA-B35 |
6C0O | 2018-08-01 | 1.9 | Crystal structure of HIV-1 K103N mutant reverse transcriptase in complex with non-nucleoside inhibitor 25a |
1M9Y | 2003-05-27 | 1.9 | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,G89A Complex. |
1FFF | 2001-06-01 | 1.9 | STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE : HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES. |
4QGI | 2014-07-16 | 1.9 | X-ray crystal structure of HIV-1 protease variant G48T/L89M in complex with Saquinavir |
4CJE | 2014-01-08 | 1.9 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4E1M | 2012-04-25 | 1.9 | Crystal Structure of HIV-1 Integrase with a non-catayltic site inhibitor |
1MET | 1998-04-15 | 1.9 | HIV-1 MUTANT (V82F) PROTEASE COMPLEXED WITH DMP323 |
1MER | 1998-04-15 | 1.9 | HIV-1 MUTANT (I84V) PROTEASE COMPLEXED WITH DMP450 |
5HGN | 2016-08-10 | 1.9 | Hexameric HIV-1 CA, apo form |
3CYH | 1996-07-11 | 1.9 | CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE SER-PRO |
4AHU | 2012-12-19 | 1.9 | Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification |
3NWX | 2011-11-02 | 1.9 | X-ray structure of ester chemical analogue [O-Ile50,O-Ile50']HIV-1 protease complexed with KVS-1 inhibitor |
1W5X | 2004-12-22 | 1.9 | HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor |
1M9D | 2003-05-27 | 1.9 | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) O-type chimera Complex. |
3NF8 | 2011-04-27 | 1.9 | Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design |
1CWI | 1998-08-12 | 1.9 | HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL 3-(N-METHYL)-D-ALANINE CYCLOSPORIN |
5TSX | 2017-11-08 | 1.9 | HIV-1 CA hexamer with NUP153 peptide - P1 crystal form |
4EP2 | 2012-06-06 | 1.9 | Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate RT-RH |
4AHR | 2012-12-19 | 1.9 | Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification |
3H47 | 2009-06-23 | 1.9 | X-ray Structure of Hexameric HIV-1 CA |
1W5Y | 2004-10-07 | 1.9 | HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor |
2ALF | 2005-08-23 | 1.9 | crystal structure of human CypA mutant K131A |
2AID | 1997-10-15 | 1.9 | STRUCTURE OF A NON-PEPTIDE INHIBITOR COMPLEXED WITH HIV-1 PROTEASE: DEVELOPING A CYCLE OF STRUCTURE-BASED DRUG DESIGN |
3NF6 | 2011-04-27 | 1.9 | Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design |
2R3W | 2008-09-02 | 1.92 | I84V HIV-1 protease in complex with a amino decorated pyrrolidine-based inhibitor |
6C0J | 2018-08-01 | 1.92 | Crystal structure of HIV-1 reverse transcriptase in complex with non-nucleoside inhibitor K-5a2 |
4U1I | 2015-04-08 | 1.92 | HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential HIV-1 escape through identical epitopes |
4Y1D | 2015-05-13 | 1.93 | Cyclic hexapeptide cyc[NdPopPKID] in complex with HIV-1 integrase core domain |
1ZJ7 | 2006-05-09 | 1.93 | Crystal structure of a complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[S-CH(OH)CH2NH]-PHE-GLU-PHE-NH2 |
6C8Y | 2018-12-05 | 1.94 | D30N HIV-1 protease in complex with a phenylboronic acid (P2') analog of darunavir |
6CGF | 2018-08-01 | 1.94 | Crystal structure of HIV-1 Y188L mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2 |
6GJP | 2018-11-07 | 1.94 | Cyclophilin A complexed with tri-vector ligand 7. |
4DQC | 2012-03-07 | 1.94 | Crystal Structure of (G16C/L38C) HIV-1 Protease in Complex with DRV |
1BIS | 1998-08-19 | 1.95 | HIV-1 INTEGRASE CORE DOMAIN |
4CF1 | 2013-12-18 | 1.95 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4CJV | 2014-01-22 | 1.95 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
6D0E | 2019-05-01 | 1.95 | X-ray crystal structure of wild type HIV-1 protease in complex with GRL-084-13 |
4CJW | 2014-01-22 | 1.95 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
2QI3 | 2008-04-22 | 1.95 | Crystal structure of protease inhibitor, MIT-2-AD94 in complex with wild type HIV-1 protease |
4CHQ | 2013-12-11 | 1.95 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4KO0 | 2013-08-14 | 1.95 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH an anilinylpyrimidine derivative (JLJ-135) |
4CJ5 | 2014-01-08 | 1.95 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4IG3 | 2013-02-06 | 1.95 | HIV-1 reverse transcriptase with bound fragment near Knuckles site |
1G2K | 2001-06-01 | 1.95 | HIV-1 PROTEASE WITH CYCLIC SULFAMIDE INHIBITOR, AHA047 |
4ID5 | 2013-02-06 | 1.95 | HIV-1 reverse transcriptase with bound fragment at the RNase H primer grip site |
4LQW | 2013-08-14 | 1.95 | Crystal structure of HIV-1 capsid N-terminal domain in complex with NUP358 cyclophilin |
3ZSX | 2012-07-11 | 1.95 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
4CF2 | 2013-11-20 | 1.95 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
3LZS | 2010-08-11 | 1.95 | Crystal Structure of HIV-1 CRF01_AE Protease in Complex with Darunavir |
3NF9 | 2011-04-27 | 1.95 | Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design |
5HGP | 2016-10-19 | 1.95 | Hexameric HIV-1 CA in complex with hexacarboxybenzene |
4CFB | 2013-11-27 | 1.95 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
3ZT3 | 2012-07-11 | 1.95 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
1BIZ | 1998-08-19 | 1.95 | HIV-1 INTEGRASE CORE DOMAIN |
3OXW | 2011-09-28 | 1.95 | Crystal Structure of HIV-1 I50V, A71V Protease in Complex with the Protease Inhibitor Darunavir |
2X2D | 2010-03-23 | 1.95 | acetyl-CypA:HIV-1 N-term capsid domain complex |
4HLA | 2013-07-24 | 1.95 | Crystal structure of wild type HIV-1 protease in complex with darunavir |
6C0L | 2018-08-01 | 1.95 | Crystal structure of HIV-1 E138K mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2 |
3MXD | 2010-11-10 | 1.95 | Crystal structure of HIV-1 protease inhibitor KC53 in complex with wild-type protease |
3LPU | 2010-05-12 | 1.95 | HIV integrase |
3ZT0 | 2012-07-11 | 1.95 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
3NFA | 2011-04-27 | 1.95 | Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design |
4XRQ | 2015-07-15 | 1.95 | Disulfide stabilized HIV-1 CA hexamer 4mut (S41A, Q67H, V165I, L172I) in complex with PF-3450074 |
4I8W | 2013-07-24 | 1.96 | Crystal structure of wild type HIV-1 protease in complex with non-peptidic inhibitor, GRL007 |
6DUF | 2018-08-01 | 1.96 | Crystal structure of HIV-1 reverse transcriptase V106A/F227L mutant in complex with non-nucleoside inhibitor 25a |
6C0K | 2018-08-01 | 1.96 | Crystal structure of HIV-1 K103N mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2 |
1D4Y | 1999-10-13 | 1.97 | HIV-1 PROTEASE TRIPLE MUTANT/TIPRANAVIR COMPLEX |
3EKX | 2009-09-01 | 1.97 | Crystal structure of the wild-type HIV-1 protease with the inhibitor, Nelfinavir |
3EKT | 2009-09-01 | 1.97 | Crystal Structure of the inhibitor Darunavir (DRV) in complex with a multi-drug resistant HIV-1 protease variant (L10F/G48V/I54V/V64I/V82A) (Refer: FLAP+ in citation.) |
3LRY | 2010-03-09 | 1.98 | Crystal structure of synthetic HIV-1 capsid C-terminal domain (CCA) |
6BHS | 2018-08-01 | 1.98 | HIV-1 CA hexamer in complex with IP6, hexagonal crystal form |
1ZSF | 2006-04-25 | 1.98 | Crystal Structure of Complex of a Hydroxyethylamine Inhibitor with HIV-1 Protease at 2.0A Resolution |
1NPV | 2003-02-04 | 2.0 | Crystal structure of HIV-1 protease complexed with LDC271 |
6H09 | 2018-08-15 | 2.0 | HIV capsid hexamer with IP6 ligand |
3EL4 | 2009-09-01 | 2.0 | Crystal structure of inhibitor saquinavir (SQV) complexed with the multidrug HIV-1 protease variant L63P/V82T/I84V |
1HPX | 1996-03-08 | 2.0 | HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR KNI-272 |
1ZBG | 2006-04-18 | 2.0 | Crystal structure of a complex of mutant hiv-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2 |
4E1N | 2012-04-25 | 2.0 | Crystal Structure of HIV-1 Integrase with a non-catayltic site inhibitor |
4FE6 | 2012-07-18 | 2.0 | Crystal Structure of HIV-1 Protease in Complex with an enamino-oxindole inhibitor |
1MT9 | 2003-01-07 | 2.0 | Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy |
1KJF | 2002-03-06 | 2.0 | SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES |
1M9C | 2003-05-27 | 2.0 | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type Complex. |
1B6P | 2000-01-07 | 2.0 | HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 7 |
1HTG | 1994-07-31 | 2.0 | X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE |
2NXL | 2007-09-18 | 2.0 | Structure of HIV-1 protease D25N complexed with the rt-rh analogue peptide GLY-ALA-GLU-VAL-PHE*TYR-VAL-ASP-GLY-ALA |
6B2K | 2018-09-26 | 2.0 | E45A/R132T mutant of HIV-1 capsid protein |
1VBS | 1999-01-13 | 2.0 | STRUCTURE OF CYCLOPHILIN COMPLEXED WITH (D)ALA CONTAINING TETRAPEPTIDE |
1A30 | 1998-04-29 | 2.0 | HIV-1 PROTEASE COMPLEXED WITH A TRIPEPTIDE INHIBITOR |
1HVJ | 1994-04-30 | 2.0 | INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE |
1A94 | 1999-01-13 | 2.0 | STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES |
5NOV | 2017-07-12 | 2.0 | Structure of cyclophilin A in complex with hexahydropyrimidine-2-thione |
4QNB | 2014-12-31 | 2.0 | Disulfide stabilized HIV-1 CA hexamer in complex with PHENYL-L-PHENYLALANINAMIDE inhibitor |
1MSN | 2003-11-04 | 2.0 | The HIV protease (mutant Q7K L33I L63I V82F I84V) complexed with KNI-764 (an inhibitor) |
5T6Z | 2017-03-01 | 2.0 | KIR3DL1 in complex with HLA-B*57:01-TW10 |
1BV9 | 1998-09-30 | 2.0 | HIV-1 PROTEASE (I84V) COMPLEXED WITH XV638 OF DUPONT PHARMACEUTICALS |
1A8K | 1999-01-13 | 2.0 | CRYSTALLOGRAPHIC ANALYSIS OF HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEASE WITH AN ANALOG OF THE CONSERVED CA-P2 SUBSTRATE: INTERACTIONS WITH FREQUENTLY OCCURRING GLUTAMIC ACID RESIDUE AT P2' POSITION OF SUBSTRATES |
2QI1 | 2008-04-22 | 2.0 | Crystal structure of protease inhibitor, MIT-1-KK81 in complex with wild type HIV-1 protease |
4JMU | 2013-10-30 | 2.0 | Crystal structure of HIV matrix residues 1-111 in complex with inhibitor |
4QJ8 | 2014-10-29 | 2.0 | Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with p1-p6 substrate variant (P453L) |
3DOX | 2008-09-09 | 2.0 | X-ray structure of HIV-1 protease in situ product complex |
6DUH | 2018-08-01 | 2.0 | Crystal structure of HIV-1 reverse transcriptase Y181I mutant in complex with non-nucleoside inhibitor 25a |
4CGD | 2013-12-04 | 2.0 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
2XYE | 2011-12-07 | 2.0 | HIV-1 Inhibitors with a Tertiary-Alcohol-containing Transition-State Mimic and various P2 and P1 prime Substituents |
3OUC | 2011-03-30 | 2.0 | MDR769 HIV-1 protease complexed with p2/NC hepta-peptide |
1K6V | 2002-02-06 | 2.0 | LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE |
2NXD | 2007-09-18 | 2.0 | Structure of HIV-1 protease D25N complexed with rt-rh analogue peptide GLY-ALA-ASP-ILE-PHE*TYR-LEU-ASP-GLY-ALA |
1RL8 | 2005-04-19 | 2.0 | Crystal structure of the complex of resistant strain of hiv-1 protease(v82a mutant) with ritonavir |
3EL0 | 2009-09-01 | 2.0 | Crystal structure of the inhibitor Nelfinavir (NFV) in complex with a multi-drug resistant HIV-1 protease variant (L10I/G48V/I54V/V64I/V82A) (Refer: FLAP+ in citation) |
1AXA | 1998-04-15 | 2.0 | ACTIVE-SITE MOBILITY IN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AS DEMONSTRATED BY CRYSTAL STRUCTURE OF A28S MUTANT |
1MSM | 2003-11-04 | 2.0 | The HIV protease (mutant Q7K L33I L63I) complexed with KNI-764 (an inhibitor) |
1DMP | 1997-11-12 | 2.0 | STRUCTURE OF HIV-1 PROTEASE COMPLEX |
5VJ3 | 2018-04-18 | 2.0 | HIV Protease (PR) in open form with Mg2+ in active site and HIVE-9 in eye site |
5VEA | 2018-04-25 | 2.0 | HIV Protease (PR) with TL-3 in active site and 4-methylbenzene-1,2-diamine in exosite |
1AJX | 1997-09-17 | 2.0 | HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC UREA INHIBITOR AHA001 |
6C0N | 2018-08-01 | 2.0 | Crystal structure of HIV-1 reverse transcriptase in complex with non-nucleoside inhibitor 25a |
1MRX | 2003-11-04 | 2.0 | Structure of HIV protease (Mutant Q7K L33I L63I V82F I84V ) complexed with KNI-577 |
1F7A | 2001-06-27 | 2.0 | HOW DOES A SYMMETRIC DIMER RECOGNIZE AN ASYMMETRIC SUBSTRATE? A SUBSTRATE COMPLEX OF HIV-1 PROTEASE. |
1TSQ | 2005-03-29 | 2.0 | CRYSTAL STRUCTURE OF AP2V SUBSTRATE VARIANT OF NC-P1 DECAMER PEPTIDE IN COMPLEX WITH V82A/D25N HIV-1 PROTEASE MUTANT |
2O4N | 2006-12-12 | 2.0 | Crystal Structure of HIV-1 Protease (TRM Mutant) in Complex with Tipranavir |
2Q3K | 2007-08-21 | 2.0 | Crystal Structure of Lysine Sulfonamide Inhibitor Reveals the Displacement of the Conserved Flap Water Molecule in HIV-1 Protease |
2AQU | 2006-08-29 | 2.0 | Structure of HIV-1 protease bound to atazanavir |
1HIV | 1993-10-31 | 2.0 | CRYSTAL STRUCTURE OF A COMPLEX OF HIV-1 PROTEASE WITH A DIHYDROETHYLENE-CONTAINING INHIBITOR: COMPARISONS WITH MOLECULAR MODELING |
1CWM | 1998-07-15 | 2.0 | HUMAN CYCLOPHILIN A COMPLEXED WITH 4 MEILE CYCLOSPORIN |
2FGU | 2006-11-07 | 2.0 | X-ray crystal structure of HIV-1 Protease T80S variant in complex with the inhibitor saquinavir used to explore the role of invariant Thr80 in HIV-1 protease structure, function, and viral infectivity. |
1KJG | 2002-03-06 | 2.0 | SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES |
1BV7 | 1998-09-30 | 2.0 | COUNTERACTING HIV-1 PROTEASE DRUG RESISTANCE: STRUCTURAL ANALYSIS OF MUTANT PROTEASES COMPLEXED WITH XV638 AND SD146, CYCLIC UREA AMIDES WITH BROAD SPECIFICITIES |
1ODY | 1999-02-16 | 2.0 | HIV-1 PROTEASE COMPLEXED WITH AN INHIBITOR LP-130 |
1NPA | 2004-01-27 | 2.0 | crystal structure of HIV-1 protease-hup |
4CJP | 2014-01-08 | 2.0 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
1NPW | 2003-02-04 | 2.0 | Crystal structure of HIV protease complexed with LGZ479 |
5HGO | 2016-08-10 | 2.0 | Hexameric HIV-1 CA R18G mutant |
1EC2 | 2002-06-26 | 2.0 | HIV-1 protease in complex with the inhibitor BEA428 |
3TLH | 1998-12-09 | 2.0 | STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITHAN EFFICIENT INHIBITOR OF FIV PR |
1BL3 | 1998-09-30 | 2.0 | CATALYTIC DOMAIN OF HIV-1 INTEGRASE |
4CHN | 2013-12-11 | 2.0 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
1KJ7 | 2002-03-06 | 2.0 | SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES |
3LPT | 2010-05-12 | 2.0 | HIV integrase |
3ZSZ | 2012-07-11 | 2.0 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
1KJH | 2002-03-06 | 2.0 | SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES |
5T9W | 2017-01-25 | 2.0 | Discovery of a Potent Cyclophilin Inhibitor (Compound 5) based on Structural Simplification of Sanglifehrin A |
5HVP | 1991-10-15 | 2.0 | CRYSTALLOGRAPHIC ANALYSIS OF A COMPLEX BETWEEN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AND ACETYL-PEPSTATIN AT 2.0-ANGSTROMS RESOLUTION |
6CPN | 2018-06-06 | 2.0 | Crystal structure of DR11 presenting the RQ13 peptide |
1AJV | 1997-08-20 | 2.0 | HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006 |
1HSG | 1996-04-03 | 2.0 | CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES |
2AZ8 | 2006-02-28 | 2.0 | HIV-1 Protease NL4-3 in complex with inhibitor, TL-3 |
1ODX | 1997-04-01 | 2.0 | HIV-1 Proteinase mutant A71T, V82A |
1MRW | 2003-11-04 | 2.0 | Structure of HIV protease (Mutant Q7K L33I L63I) complexed with KNI-577 |
5V5L | 2017-06-14 | 2.0 | Crystal structure of HLA-B*5801 complex with HIV-1 gag derived peptide TW10 |
7UPJ | 1997-04-21 | 2.0 | HIV-1 PROTEASE/U101935 COMPLEX |
6EX9 | 2018-06-06 | 2.01 | Crystal Structure of HIV-1 Integrase Catalytic Core Domain with Inhibitor Peptide |
3DPH | 2008-09-02 | 2.01 | HIV-1 capsid C-terminal domain mutant (L211S) |
2AZC | 2006-02-28 | 2.01 | HIV-1 Protease NL4-3 6X mutant |
1EBZ | 2002-06-26 | 2.01 | HIV-1 protease in complex with the inhibitor BEA388 |
4XRO | 2015-07-15 | 2.01 | Disulfide stabilized HIV-1 CA hexamer 4mut (S41A, Q67H, V165I, L172I) |
1B92 | 1999-07-19 | 2.02 | MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY |
1ZPA | 2005-05-31 | 2.02 | HIV Protease with Scripps AB-3 Inhibitor |
2B4J | 2005-10-25 | 2.02 | Structural basis for the recognition between HIV-1 integrase and LEDGF/p75 |
2AZB | 2006-02-28 | 2.03 | HIV-1 Protease NL4-3 3X mutant in complex with inhibitor, TL-3 |
4U0E | 2014-11-12 | 2.04 | Hexameric HIV-1 CA in complex with PF3450074 |
3K2P | 2010-02-09 | 2.04 | HIV-1 Reverse Transcriptase Isolated RnaseH Domain with the Inhibitor beta-thujaplicinol Bound at the Active Site |
5HGM | 2016-08-10 | 2.04 | Hexameric HIV-1 CA in complex with dATP |
3U7S | 2012-01-18 | 2.05 | HIV PR drug resistant patient's variant in complex with darunavir |
4U0A | 2014-11-12 | 2.05 | Hexameric HIV-1 CA in complex with CPSF6 peptide, P6 crystal form |
4CFA | 2013-11-27 | 2.05 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
4IFV | 2013-02-06 | 2.05 | Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-Ray Crystallographic Fragment Screening |
6C0R | 2018-08-01 | 2.05 | Crystal structure of HIV-1 K103N/Y181C mutant reverse transcriptase in complex with non-nucleoside inhibitor 25a |
4O0J | 2014-07-02 | 2.05 | HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[4-(4-chlorophenyl)-6-(3,4-dimethylphenyl)-2,5-dimethylpyridin-3-yl]ethanoic acid |
1CPI | 1996-03-08 | 2.05 | REGIOSELECTIVE STRUCTURAL AND FUNCTIONAL MIMICRY OF PEPTIDES. DESIGN OF HYDROLYTICALLY STABLE CYCLIC PEPTIDOMIMETIC INHIBITORS OF HIV-1 PROTEASE |
5TEO | 2017-09-27 | 2.05 | Dimer of HIV-1 Gag CTD-SP1 fragment |
6C0P | 2018-08-01 | 2.05 | Crystal structure of HIV-1 E138K mutant reverse transcriptase in complex with non-nucleoside inhibitor 25a |
1EBK | 2000-07-26 | 2.06 | Structural and kinetic analysis of drug resistant mutants of HIV-1 protease |
1ZSR | 2006-04-25 | 2.06 | Crystal structure of wild type HIV-1 protease (BRU isolate) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[S-CH(OH)CH2NH]-PHE-GLU-PHE-NH2 |
4CGI | 2013-12-04 | 2.07 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
3PSU | 2011-12-07 | 2.07 | HIV-1 protease in complex with an isobutyl decorated oligoamine (symmetric binding mode) |
4JLH | 2013-05-01 | 2.09 | HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor |
3QIP | 2011-04-20 | 2.09 | Structure of HIV-1 reverse transcriptase in complex with an RNase H inhibitor and nevirapine |
5W4O | 2018-06-20 | 2.09 | Structure of the R18A mutant of the HIV-1 capsid protein |
3AVN | 2012-01-18 | 2.1 | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site |
5CYH | 1996-07-11 | 2.1 | CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE GLY-PRO |
1ODW | 1997-04-01 | 2.1 | Native HIV-1 Proteinase |
3T3C | 2012-06-20 | 2.1 | Structure of HIV PR resistant patient derived mutant (comprising 22 mutations) in complex with DRV |
4PHV | 1993-10-31 | 2.1 | X-RAY CRYSTAL STRUCTURE OF THE HIV PROTEASE COMPLEX WITH L-700,417, AN INHIBITOR WITH PSEUDO C2 SYMMETRY |
3EM6 | 2009-09-01 | 2.1 | Crystal structure of I50L/A71V mutant of hiv-1 protease in complex with inhibitor darunavir |
4IDK | 2013-02-06 | 2.1 | HIV-1 reverse transcriptase with bound fragment at the 428 site |
1T7K | 2004-10-05 | 2.1 | Crystal Structure of HIV Protease complexed with Arylsulfonamide azacyclic urea |
4CE9 | 2013-11-20 | 2.1 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
1TSU | 2005-03-29 | 2.1 | CRYSTAL STRUCTURE OF DECAMER NCP1 SUBSTRATE PEPTIDE IN COMPLEX WITH WILD-TYPE D25N HIV-1 PROTEASE VARIANT |
2RMA | 1995-02-07 | 2.1 | Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A |
4CF9 | 2013-11-27 | 2.1 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
1NMK | 2003-04-01 | 2.1 | The Sanglifehrin-Cyclophilin Interaction: Degradation Work, Synthetic Macrocyclic Analogues, X-ray Crystal Structure and Binding Data |
5T70 | 2017-03-01 | 2.1 | KIR3DL1 in complex with HLA-B*57:01 presenting TSNLQEQIGW |
2X4U | 2010-03-02 | 2.1 | Crystal structure of MHC CLass I HLA-A2.1 bound to HIV-1 Peptide RT468-476 |
1CWA | 1996-01-29 | 2.1 | X-RAY STRUCTURE OF A MONOMERIC CYCLOPHILIN A-CYCLOSPORIN A CRYSTAL COMPLEX AT 2.1 ANGSTROMS RESOLUTION |
4FAF | 2012-08-29 | 2.1 | Substrate CA/p2 in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant |
1LV1 | 2002-06-19 | 2.1 | Crystal Structure Analysis of the non-active site mutant of tethered HIV-1 protease to 2.1A resolution |
2RMB | 1995-02-07 | 2.1 | Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A |
4IFY | 2013-02-06 | 2.1 | HIV-1 reverse transcriptase with bound fragment at the Knuckles site |
3BGR | 2008-02-12 | 2.1 | Crystal structure of K103N/Y181C mutant HIV-1 reverse transcriptase (RT) in complex with TMC278 (Rilpivirine), a non-nucleoside RT inhibitor |
2QI0 | 2008-04-22 | 2.1 | Crystal structure of protease inhibitor, MIT-1-KK80 in complex with wild type HIV-1 protease |
1EC1 | 2002-06-26 | 2.1 | HIV-1 protease in complex with the inhibitor BEA409 |
5CYM | 2015-12-30 | 2.1 | HIV-1 reverse transcriptase complexed with 4-iodopyrazole |
3EM4 | 2009-09-01 | 2.1 | Crystal structure of atazanavir (ATV) in complex with I50L/A71V drug-resistant HIV-1 protease |
4CYH | 1996-07-11 | 2.1 | CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE HIS-PRO |
1QS4 | 1999-11-17 | 2.1 | Core domain of HIV-1 integrase complexed with Mg++ and 1-(5-chloroindol-3-yl)-3-hydroxy-3-(2H-tetrazol-5-yl)-propenone |
1QBT | 1997-10-15 | 2.1 | HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY |
2YKN | 2011-08-17 | 2.12 | Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with a Difluoromethylbenzoxazole (DFMB) Pyrimidine Thioether derivative, a non-nucleoside RT inhibitor (NNRTI) |
2YNG | 2013-01-09 | 2.12 | HIV-1 Reverse Transcriptase in complex with inhibitor GSK560 |
5IND | 2016-10-05 | 2.13 | Crystal structure of HLA-B5801, a protective HLA allele for HIV-1 infection |
4QJ2 | 2014-10-29 | 2.13 | Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with WT p1-p6 substrate |
3RDD | 2012-03-21 | 2.14 | Human Cyclophilin A Complexed with an Inhibitor |
4CGJ | 2013-12-04 | 2.15 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
1MT8 | 2003-01-07 | 2.15 | Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy |
5CYQ | 2015-12-30 | 2.15 | HIV-1 reverse transcriptase complexed with 4-bromopyrazole |
4CFD | 2013-11-27 | 2.15 | Interrogating HIV integrase for compounds that bind- a SAMPL challenge |
1IZI | 2002-12-23 | 2.15 | Inhibitor of HIV protease with unusual binding mode potently inhibiting multi-resistant protease mutants |
1ZTZ | 2005-11-01 | 2.15 | Crystal structure of HIV protease- metallacarborane complex |
6JCF | 2019-07-17 | 2.15 | Cryogenic structure of HIV-1 Integrase catalytic core domain by synchrotron |
3LZV | 2010-08-11 | 2.15 | Structure of Nelfinavir-resistant HIV-1 protease (D30N/N88D) in complex with Darunavir. |
4DG1 | 2012-06-20 | 2.15 | Crystal structure of HIV-1 reverse transcriptase (RT) with polymorphism mutation K172A and K173A |
3EKP | 2009-09-01 | 2.15 | Crystal Structure of the inhibitor Amprenavir (APV) in complex with a multi-drug resistant HIV-1 protease variant (L10I/G48V/I54V/V64I/V82A)Refer: FLAP+ in citation |
4GVM | 2013-05-01 | 2.16 | HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor |
4LH5 | 2013-12-25 | 2.19 | Dual inhibition of HIV-1 replication by Integrase-LEDGF allosteric inhibitors is predominant at post-integration stage during virus production rather than at integration |
5W4P | 2018-06-20 | 2.19 | Structure of the E28A mutant of the HIV-1 capsid protein |
4DGE | 2012-02-08 | 2.2 | TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant, HIV-1 CA(O-loop) complex |
1YTH | 1997-03-12 | 2.2 | SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT |
3ZT4 | 2012-07-18 | 2.2 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
1U8G | 2004-11-02 | 2.2 | Crystal structure of a HIV-1 Protease in complex with peptidomimetic inhibitor KI2-PHE-GLU-GLU-NH2 |
1VRT | 1996-04-03 | 2.2 | HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES |
3ZSY | 2012-07-11 | 2.2 | Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design |
3EKQ | 2009-09-01 | 2.2 | Crystal structure of inhibitor saquinavir (SQV) in complex with multi-drug resistant HIV-1 protease (L63P/V82T/I84V) (referred to as ACT in paper) |
1E27 | 2000-09-12 | 2.2 | Nonstandard peptide binding of HLA-B*5101 complexed with HIV immunodominant epitope KM1(LPPVVAKEI) |
1LZQ | 2003-04-29 | 2.2 | Crystal structure of the complex of mutant HIV-1 protease (A71V, V82T, I84V) with an ethylenamine peptidomimetic inhibitor BOC-PHE-PSI[CH2CH2NH]-PHE-GLU-PHE-NH2 |
5OIA | 2018-03-07 | 2.2 | Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 |
1RTH | 1996-04-03 | 2.2 | HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES |
3UHL | 2012-03-28 | 2.2 | Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with p2-NC substrate analog |
1HAR | 1995-04-20 | 2.2 | 2.2 ANGSTROMS RESOLUTION STRUCTURE OF THE AMINO-TERMINAL HALF OF HIV-1 REVERSE TRANSCRIPTASE (FINGERS AND PALM SUBDOMAINS) |
2QAK | 2008-07-01 | 2.2 | HIV-1 PR mutant in complex with nelfinavir |
1Z8C | 2006-03-21 | 2.2 | Crystal structure of the complex of mutant HIV-1 protease (l63P, A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2 |
4F74 | 2013-05-15 | 2.2 | Crystal Structure of active HIV-1 Protease in Complex with the N terminal product of the substrate MA-CA. |
1AID | 1997-10-15 | 2.2 | STRUCTURE OF A NON-PEPTIDE INHIBITOR COMPLEXED WITH HIV-1 PROTEASE: DEVELOPING A CYCLE OF STRUCTURE-BASED DRUG DESIGN |
1K6C | 2002-02-06 | 2.2 | LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE |
1N49 | 2003-01-07 | 2.2 | Viability of a Drug-Resistant HIV-1 Protease Variant: Structural Insights for Better Anti-Viral Therapy |
1HEF | 1994-05-31 | 2.2 | The crystal structures at 2.2 angstroms resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations |
1HTF | 1994-07-31 | 2.2 | X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE |
3EM3 | 2009-09-01 | 2.2 | Crystal structure of amprenavir (APV) in complex with a drug resistant HIV-1 protease variant (I50L/A71V). |
1BHL | 1998-10-14 | 2.2 | CACODYLATED CATALYTIC DOMAIN OF HIV-1 INTEGRASE |
5OI2 | 2018-03-07 | 2.2 | Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 |
1CWB | 1996-01-29 | 2.2 | THE X-RAY STRUCTURE OF (MEBM2T)1-CYCLOSPORIN COMPLEXED WITH CYCLOPHILIN A PROVIDES AN EXPLANATION FOR ITS ANOMALOUSLY HIGH IMMUNOSUPPRESSIVE ACTIVITY |
2Q63 | 2008-02-26 | 2.2 | HIV-1 PR mutant in complex with nelfinavir |
3KDC | 2010-03-16 | 2.2 | Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10074 |
6ELI | 2018-04-11 | 2.2 | Structure of HIV-1 reverse transcriptase (RT) in complex with rilpivirine and an RNase H inhibitor XZ462 |
3ODI | 2011-02-16 | 2.2 | Crystal structure of cyclophilin A in complex with Voclosporin E-ISA247 |
1T7J | 2005-05-10 | 2.2 | crystal structure of inhibitor amprenavir in complex with a multi-drug resistant variant of HIV-1 protease (L63P/V82T/I84V) |
2B7Z | 2006-11-14 | 2.2 | Structure of HIV-1 protease mutant bound to indinavir |
1HIH | 1995-07-10 | 2.2 | COMPARATIVE ANALYSIS OF THE X-RAY STRUCTURES OF HIV-1 AND HIV-2 PROTEASES IN COMPLEX WITH CGP 53820, A NOVEL PSEUDOSYMMETRIC INHIBITOR |
1K2C | 2002-07-10 | 2.2 | Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance |
1HEG | 1994-05-31 | 2.2 | The crystal structures at 2.2 angstroms resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations |
1K6P | 2002-02-06 | 2.2 | LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE |
3DLG | 2008-08-12 | 2.2 | Crystal structure of hiv-1 reverse transcriptase in complex with GW564511. |
6B2J | 2018-09-26 | 2.21 | E45A mutant of HIV-1 capsid protein (other crystal form) |
1UPJ | 1996-10-14 | 2.22 | HIV-1 PROTEASE COMPLEX WITH U095438 [3-[1-(4-BROMOPHENYL) ISOBUTYL]-4-HYDROXYCOUMARIN |
4U0F | 2014-11-12 | 2.22 | Hexameric HIV-1 CA in Complex with BI-2 |
3T11 | 2012-08-22 | 2.22 | Dimeric inhibitor of HIV-1 protease. |
6DUG | 2018-08-01 | 2.22 | Crystal structure of HIV-1 reverse transcriptase K101P mutant in complex with non-nucleoside inhibitor 25a |
3TTP | 2012-09-26 | 2.23 | Structure of multiresistant HIV-1 protease in complex with darunavir |
5VQZ | 2017-08-23 | 2.23 | Crystal Structure of HIV-1 Reverse Transcriptase (K103N, Y181C) Variant in Complex with 2-chloro-N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacetamide (JLJ686), a Non-nucleoside Inhibitor |
3LP1 | 2010-06-09 | 2.23 | HIV-1 reverse transcriptase with inhibitor |
4O55 | 2014-07-02 | 2.24 | HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[6-(5-chloro-1H-benzimidazol-2-yl)-2,5-dimethyl-4-phenylpyridin-3-yl]ethanoic acid |
2NXM | 2007-09-18 | 2.25 | Structure of HIV-1 protease D25N complexed with the rt-rh analogue peptide GLY-ALA-GLN-THR-PHE*TYR-VAL-ASP-GLY-ALA |
3PJ6 | 2011-04-06 | 2.25 | Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants |
1SJH | 2004-08-17 | 2.25 | HLA-DR1 complexed with a 13 residue HIV capsid peptide |
1HVS | 1995-02-14 | 2.25 | STRUCTURAL BASIS OF DRUG RESISTANCE FOR THE V82A MUTANT OF HIV-1 PROTEASE: BACKBONE FLEXIBILITY AND SUBSITE REPACKING |
1K6T | 2002-02-06 | 2.25 | LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE |
3OQA | 2011-04-06 | 2.25 | Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants |
5W4Q | 2018-06-20 | 2.29 | Structure of the R18A/E28A mutant of the HIV-1 capsid protein |
1EBY | 2002-06-26 | 2.29 | HIV-1 protease in complex with the inhibitor BEA369 |
1ITG | 1995-05-08 | 2.3 | CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE: SIMILARITY TO OTHER POLYNUCLEOTIDYL TRANSFERASES |
5D3G | 2015-09-30 | 2.3 | Structure of HIV-1 Reverse Transcriptase Bound to a Novel 38-mer Hairpin Template-Primer DNA Aptamer |
2R5Q | 2007-11-20 | 2.3 | Crystal Structure Analysis of HIV-1 Subtype C Protease Complexed with Nelfinavir |
1GNO | 1996-11-08 | 2.3 | HIV-1 PROTEASE (WILD TYPE) COMPLEXED WITH U89360E (INHIBITOR) |
1HBV | 1995-07-10 | 2.3 | A CHECK ON RATIONAL DRUG DESIGN. CRYSTAL STRUCTURE OF A COMPLEX OF HIV-1 PROTEASE WITH A NOVEL GAMMA-TURN MIMETIC |
4Y1C | 2015-02-25 | 2.3 | Cyclic hexapeptide cyc[NdPopPKID] in complex with HIV-1 integrase core domain |
4KV8 | 2013-07-31 | 2.3 | Crystal structure of HIV RT in complex with BILR0355BS |
1GNN | 1996-11-08 | 2.3 | HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASN (V82N) COMPLEXED WITH U89360E (INHIBITOR) |
1SBG | 1994-10-15 | 2.3 | AN ORALLY-BIOAVAILABLE HIV-1 PROTEASE INHIBITOR CONTAINING AN IMIDAZOLE-DERIVED PEPTIDE BOND REPLACEMENT. CRYSTALLOGRAPHIC AND PHARMACOKINETIC ANALYSIS |
1A9M | 1998-06-17 | 2.3 | G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E |
1HOS | 1993-10-31 | 2.3 | INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE BY A C2-SYMMETRIC PHOSPHINATE SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS |
5T9U | 2017-01-25 | 2.3 | Discovery of a Potent Cyclophilin Inhibitor (Compound 3) based on Structural Simplification of Sanglifehrin A |
6AXR | 2018-09-12 | 2.3 | Structure of the P122A mutant of the HIV-1 capsid protein |
2QNQ | 2008-04-15 | 2.3 | HIV-1 Protease in complex with a chloro decorated pyrrolidine-based inhibitor |
1GNM | 1996-11-08 | 2.3 | HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASP (V82D) COMPLEXED WITH U89360E (INHIBITOR) |
1ZLF | 2006-04-25 | 2.3 | Crystal structure of a complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor |
3LAK | 2010-02-23 | 2.3 | Crystal structure of HIV-1 reverse transcriptase in complex with N1-heterocycle pyrimidinedione non-nucleoside inhibitor |
4I2P | 2013-01-16 | 2.3 | Crystal structure of HIV-1 reverse transcriptase in complex with rilpivirine (TMC278) based analogue |
3DYA | 2008-11-25 | 2.3 | HIV-1 RT with non-nucleoside inhibitor annulated Pyrazole 1 |
1HPS | 1994-08-31 | 2.3 | RATIONAL DESIGN, SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS OF A HYDROXYETHYLENE-BASED HIV-1 PROTEASE INHIBITOR CONTAINING A HETEROCYCLIC P1'-P2' AMIDE BOND ISOSTERE |
2R5P | 2007-11-20 | 2.3 | Crystal Structure Analysis of HIV-1 Subtype C Protease Complexed with Indinavir |
5OI3 | 2018-03-07 | 2.3 | Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 |
4HVP | 1990-04-15 | 2.3 | Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 Angstroms resolution |
1HXB | 1997-03-12 | 2.3 | HIV-1 proteinase complexed with RO 31-8959 |
1HIW | 1996-10-14 | 2.3 | TRIMERIC HIV-1 MATRIX PROTEIN |
2RKI | 2008-04-22 | 2.3 | Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with a triazole derived NNRTI |
3MEC | 2010-05-12 | 2.3 | HIV-1 Reverse Transcriptase in Complex with TMC125 |
1VBT | 1999-01-13 | 2.3 | Structure of cyclophilin complexed with sulfur-substituted tetrapeptide AAPF |
2OPS | 2007-05-22 | 2.3 | Crystal Structure of Y188C Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X. |
1HYZ | 2001-04-04 | 2.3 | HIV INTEGRASE CORE DOMAIN COMPLEXED WITH A DERIVATIVE OF TETRAPHENYL ARSONIUM. |
1YTG | 1997-03-12 | 2.3 | SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT |
1TCX | 1996-12-07 | 2.3 | HIV TRIPLE MUTANT PROTEASE COMPLEXED WITH INHIBITOR SB203386 |
2Z54 | 2008-07-01 | 2.31 | The Influence of I47A Mutation on Reduced Susceptibility to the Protease Inhibitor Lopinavir |
4K4P | 2013-09-18 | 2.31 | TL-3 inhibited Trp6Ala HIV Protease |
3ODL | 2011-02-16 | 2.31 | Crystal structure of cyclophilin A in complex with Voclosporin Z-ISA247 |
3K0Q | 2009-12-08 | 2.32 | Cryogenic structure of CypA mutant Ser99Thr (2) |
1AWV | 1998-03-18 | 2.34 | CYPA COMPLEXED WITH HVGPIA |
5KGW | 2016-10-19 | 2.34 | HIV1 catalytic core domain in complex with inhibitor: (2~{S})-2-[3-(3,4-dihydro-2~{H}-chromen-6-yl)-1-methyl-indol-2-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid |
1AWU | 1998-03-18 | 2.34 | CYPA COMPLEXED WITH HVGPIA (PSEUDO-SYMMETRIC MONOMER) |
4EJ8 | 2013-05-01 | 2.35 | Apo HIV Protease (PR) dimer in closed form with fragment 1F1 in the outside/top of flap |
5VQY | 2017-08-23 | 2.35 | Crystal Structure of HIV-1 Reverse Transcriptase (K103N, Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacrylamide (JLJ684), a Non-nucleoside Inhibitor |
5OI8 | 2018-03-07 | 2.35 | Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 |
1RTJ | 1996-04-03 | 2.35 | MECHANISM OF INHIBITION OF HIV-1 REVERSE TRANSCRIPTASE BY NON-NUCLEOSIDE INHIBITORS |
4CPQ | 2014-12-17 | 2.35 | Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol |
2YNF | 2013-01-09 | 2.36 | HIV-1 Reverse Transcriptase Y188L mutant in complex with inhibitor GSK560 |
1AK4 | 1997-10-15 | 2.36 | HUMAN CYCLOPHILIN A BOUND TO THE AMINO-TERMINAL DOMAIN OF HIV-1 CAPSID |
4O5B | 2014-07-02 | 2.37 | HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[6-(5-chloro-1H-benzimidazol-2-yl)-2,5-dimethyl-4-phenylpyridin-3-yl]ethanoic acid |
5XN2 | 2018-02-07 | 2.38 | HIV-1 reverse transcriptase Q151M:DNA:dGTP ternary complex |
6ECL | 2019-08-21 | 2.38 | Crystal Structure of a 1,2,4-Triazole Allosteric RNase H Inhibitor in Complex with HIV Reverse Transcriptase |
6EWA | 2018-11-07 | 2.39 | Crystal structure of HLA-A2 in complex with LILRB1 |
6AXT | 2018-09-12 | 2.4 | Structure of the T58S/T107I/P122A mutant of the HIV-1 capsid protein |
5OI5 | 2018-03-07 | 2.4 | Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 |
6CQL | 2018-06-06 | 2.4 | Crystal structure of F24 TCR -DR11-RQ13 peptide complex |
6AXW | 2018-09-12 | 2.4 | Structure of the I124A mutant of the HIV-1 capsid protein |
1RMH | 1996-10-14 | 2.4 | RECOMBINANT CYCLOPHILIN A FROM HUMAN T CELL |
1VIK | 1998-12-09 | 2.4 | HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR HOE/BAY 793 ORTHORHOMBIC FORM |
3T1A | 2011-10-26 | 2.4 | Crystal Structure of HIV-1 Reverse Transcriptase (K103N mutant) in Complex with Inhibitor M05 |
7HVP | 1993-07-15 | 2.4 | X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN A SYNTHETIC PROTEASE OF HUMAN IMMUNODEFICIENCY VIRUS 1 AND A SUBSTRATE-BASED HYDROXYETHYLAMINE INHIBITOR |
1K6Y | 2001-12-21 | 2.4 | Crystal Structure of a Two-Domain Fragment of HIV-1 Integrase |
1HRH | 1992-01-15 | 2.4 | CRYSTAL STRUCTURE OF THE RIBONUCLEASE H DOMAIN OF HIV-1 REVERSE TRANSCRIPTASE |
1VRU | 1996-04-03 | 2.4 | HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES |
5VQX | 2017-08-23 | 2.4 | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with 2-chloro-N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacetamide (JLJ686), a Non-nucleoside Inhibitor |
3MEE | 2010-05-12 | 2.4 | HIV-1 Reverse Transcriptase in Complex with TMC278 |
5K14 | 2016-06-29 | 2.4 | HIV-1 Reverse Transcriptase in complex with a 2,6-difluorophenyl DAPY analog |
4G8G | 2013-03-20 | 2.4 | Crystal Structure of C12C TCR-HA B2705-KK10 |
6CPO | 2018-06-06 | 2.4 | Crystal structure of DR15 presenting the RQ13 peptide |
6AXS | 2018-09-12 | 2.4 | Structure of the V11I/T58A/P122A mutant of the HIV-1 capsid protein |
6AYA | 2018-09-12 | 2.4 | Structure of the native full-length HIV-1 capsid protein in complex with Nup153 peptide |
1VIJ | 1999-01-13 | 2.4 | HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR HOE/BAY 793 HEXAGONAL FORM |
6O9E | 2019-10-23 | 2.4 | Structure of HIV-1 Reverse Transcriptase in complex with DNA and INDOPY-1 |
3DS5 | 2008-09-02 | 2.4 | HIV-1 capsid C-terminal domain mutant (N183A) |
1Q94 | 2004-06-01 | 2.4 | Structures of HLA-A*1101 in complex with immunodominant nonamer and decamer HIV-1 epitopes clearly reveal the presence of a middle anchor residue |
2RF2 | 2008-01-01 | 2.4 | HIV reverse transcriptase in complex with inhibitor 7e (NNRTI) |
1S1T | 2004-06-29 | 2.4 | Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with UC-781 |
2X2C | 2010-03-23 | 2.41 | acetyl-CypA:cyclosporine complex |
6B2G | 2018-09-26 | 2.41 | P38A mutant of HIV-1 capsid protein |
3K0R | 2009-12-08 | 2.42 | Cryogenic structure of CypA mutant Arg55Lys |
5J2M | 2016-08-03 | 2.43 | HIV-1 reverse transcriptase in complex with DNA and EFdA-triphosphate, a translocation-defective RT inhibitor |
2BE2 | 2005-12-06 | 2.43 | Crystal structure of HIV-1 reverse transcriptase (RT) in complex with R221239 |
6IK9 | 2019-01-30 | 2.43 | HIV-1 reverse transcriptase with Q151M/G112S/D113A/Y115F/F116Y/F160L/I159L:DNA:dGTP ternary complex |
4XFX | 2015-06-10 | 2.43 | Structure of the native full-length HIV-1 capsid protein |
6BSG | 2018-01-03 | 2.44 | Structure of HIV-1 RT complexed with RNA/DNA hybrid in an RNA hydrolysis-off mode |
4EJL | 2013-05-01 | 2.44 | Apo HIV Protease (PR) dimer in closed form with fragment 1F1-N in the outside/top of flap |
1M0B | 2004-01-13 | 2.45 | HIV-1 protease in complex with an ethyleneamine inhibitor |
4DMN | 2012-03-21 | 2.45 | HIV-1 Integrase Catalytical Core Domain |
4QLH | 2014-08-06 | 2.45 | Crystal structure of drug resistant V82S/V1082S HIV-1 Protease |
5XN1 | 2018-02-07 | 2.45 | HIV-1 reverse transcriptase Q151M:DNA:entecavir-triphosphate ternary complex |
4COE | 2014-12-10 | 2.45 | Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol |
1SJE | 2004-08-17 | 2.45 | HLA-DR1 complexed with a 16 residue HIV capsid peptide bound in a hairpin conformation |
6CPL | 2018-06-06 | 2.45 | Crystal structure of DR11 presenting the gag293 epitope |
4WE1 | 2014-12-03 | 2.49 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ600) |
2YNI | 2013-01-09 | 2.49 | HIV-1 Reverse Transcriptase in complex with inhibitor GSK952 |
6AMO | 2018-08-15 | 2.5 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 7.0 |
3N3I | 2010-06-09 | 2.5 | Crystal Structure of G48V/C95F tethered HIV-1 Protease/Saquinavir complex |
1D4S | 1999-10-12 | 2.5 | HIV-1 PROTEASE V82F/I84V DOUBLE MUTANT/TIPRANAVIR COMPLEX |
1HPO | 1997-04-21 | 2.5 | HIV-1 PROTEASE TRIPLE MUTANT/U103265 COMPLEX |
1EP4 | 2000-09-27 | 2.5 | Crystal structure of HIV-1 reverse transcriptase in complex with S-1153 |
4IG0 | 2013-02-06 | 2.5 | HIV-1 reverse transcriptase with bound fragment at the 507 site |
1BDQ | 1998-08-12 | 2.5 | HIV-1 (2:31-37, 47, 82) PROTEASE COMPLEXED WITH INHIBITOR SB203386 |
6B2I | 2018-09-26 | 2.5 | E45A mutant of the HIV-1 capsid protein |
6AY9 | 2018-09-12 | 2.5 | Structure of the native full-length HIV-1 capsid protein in complex with CPSF6 peptide |
1SH9 | 2004-10-05 | 2.5 | Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease |
4I7F | 2013-02-20 | 2.5 | HIV-1 Reverse Transcriptase in complex with a phosphonate analog of nevirapine |
3GGA | 2009-05-26 | 2.5 | HIV Protease inhibitors with pseudo-symmetric cores |
1BI4 | 1998-11-04 | 2.5 | CATALYTIC DOMAIN OF HIV-1 INTEGRASE |
5TSV | 2017-11-08 | 2.5 | HIV-1 CA hexamer with NUP153 peptide - R3 crystal form |
3MED | 2010-05-12 | 2.5 | HIV-1 K103N Reverse Transcriptase in Complex with TMC125 |
5VQS | 2017-08-23 | 2.5 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)acrylamide (JLJ685), a Non-nucleoside Inhibitor |
1FK9 | 2000-11-03 | 2.5 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ) |
1BIU | 1998-08-19 | 2.5 | HIV-1 INTEGRASE CORE DOMAIN COMPLEXED WITH MG++ |
2BPZ | 1999-02-23 | 2.5 | HIV-1 protease-inhibitor complex |
1HHJ | 1993-10-31 | 2.5 | THE ANTIGENIC IDENTITY OF PEPTIDE(SLASH)MHC COMPLEXES: A COMPARISON OF THE CONFORMATION OF FIVE PEPTIDES PRESENTED BY HLA-A2 |
5VQW | 2017-08-23 | 2.5 | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)acrylamide (JLJ685), a Non-nucleoside Inhibitor |
5IM7 | 2016-10-05 | 2.5 | Crystal structure of HLA-B5801, a protective HLA allele for HIV-1 infection |
2AZ9 | 2006-02-28 | 2.5 | HIV-1 Protease NL4-3 1X mutant |
8HVP | 1993-10-31 | 2.5 | STRUCTURE AT 2.5-ANGSTROMS RESOLUTION OF CHEMICALLY SYNTHESIZED HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE COMPLEXED WITH A HYDROXYETHYLENE*-BASED INHIBITOR |
1MTB | 2003-01-07 | 2.5 | Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy |
2HNY | 2006-09-05 | 2.5 | Crystal Structure of E138K Mutant HIV-1 Reverse Transcriptase in Complex with Nevirapine |
3AID | 1997-09-17 | 2.5 | A NEW CLASS OF HIV-1 PROTEASE INHIBITOR: THE CRYSTALLOGRAPHIC STRUCTURE, INHIBITION AND CHEMICAL SYNTHESIS OF AN AMINIMIDE PEPTIDE ISOSTERE |
3P05 | 2011-01-12 | 2.5 | X-ray structure of pentameric HIV-1 CA |
6CQN | 2018-06-06 | 2.5 | Crystal structure of F5 TCR -DR11-RQ13 peptide complex |
2HND | 2006-09-05 | 2.5 | Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with Nevirapine |
1JKH | 2001-10-03 | 2.5 | CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ) |
6JCG | 2019-07-17 | 2.5 | Room temperature structure of HIV-1 Integrase catalytic core domain by serial femtosecond crystallography. |
2IAJ | 2006-12-19 | 2.5 | Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with ATP |
1JLA | 2001-10-03 | 2.5 | CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-651 |
1A8G | 1998-07-15 | 2.5 | HIV-1 PROTEASE IN COMPLEX WITH SDZ283-910 |
5TXL | 2017-04-05 | 2.5 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP |
2Q64 | 2008-02-26 | 2.5 | HIV-1 PR mutant in complex with nelfinavir |
3ISN | 2010-03-16 | 2.5 | Crystal structure of HIV-1 RT bound to A 6-vinylpyrimidine inhibitor |
1C1B | 2000-07-21 | 2.5 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GCA-186 |
6AVM | 2018-08-15 | 2.5 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 9.5 WITH CROSS-LINKING TO SECOND BASE TEMPLATE OVERHANG |
1AAQ | 1994-06-22 | 2.5 | HYDROXYETHYLENE ISOSTERE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE: STRUCTURE-ACTIVITY ANALYSIS USING ENZYME KINETICS, X-RAY CRYSTALLOGRAPHY, AND INFECTED T-CELL ASSAYS |
3DLE | 2008-08-12 | 2.5 | Crystal structure of hiv-1 reverse transcriptase in complex with GF128590. |
1C1C | 2000-07-21 | 2.5 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-6123 |
4PQU | 2014-06-18 | 2.51 | Crystal structure of HIV-1 Reverse Transcriptase in complex with RNA/DNA and dATP |
3LAL | 2010-02-23 | 2.51 | Crystal structure of HIV-1 reverse transcriptase in complex with N1-ethyl pyrimidinedione non-nucleoside inhibitor |
3TAM | 2011-10-26 | 2.51 | Crystal structure of HIV-1 reverse transcriptase (K103N mutant) in complex with inhibitor M06 |
1C0U | 2000-07-19 | 2.52 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+50.0934 |
6OR7 | 2019-07-24 | 2.53 | Structure of HIV-1 Reverse Transcriptase (RT) in complex with DNA AND (-)FTC-TP |
5J2P | 2016-08-03 | 2.53 | HIV-1 reverse transcriptase in complex with DNA that has incorporated EFdA-MP at the P-(post-translocation) site and a second EFdA-MP at the N-(pre-translocation) site |
3IS9 | 2010-04-07 | 2.55 | Crystal structure of the HIV-1 reverse transcriptase (RT) in complex with the alkenyldiarylmethane (ADAM) Non-nucleoside RT Inhibitor dimethyl 3,3'-(6-methoxy-6-oxohex-1-ene-1,1-diyl)bis(5-cyano-6-methoxybenzoate). |
1ZKF | 2006-04-11 | 2.55 | Cyrstal Structure of Human Cyclophilin-A in Complex with suc-AGPF-pNA |
5TXN | 2017-04-05 | 2.55 | STRUCTURE OF Q151M MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP |
2R05 | 2007-12-18 | 2.55 | Crystal Structure of ALIX/AIP1 in complex with the HIV-1 YPLASL Late Domain |
1AWS | 1998-03-18 | 2.55 | SECYPA COMPLEXED WITH HAGPIA (PSEUDO-SYMMETRIC MONOMER) |
1RT2 | 1997-04-21 | 2.55 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH TNK-651 |
1AWT | 1998-03-18 | 2.55 | SECYPA COMPLEXED WITH HAGPIA |
2OPP | 2007-05-22 | 2.55 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with GW420867X. |
5VQQ | 2017-08-23 | 2.55 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-2-fluoro-N-methylacetamide (JLJ683), a Non-nucleoside Inhibitor |
3LAN | 2010-02-23 | 2.55 | Crystal structure of HIV-1 reverse transcriptase in complex with N1-butyl pyrimidinedione non-nucleoside inhibitor |
5VQR | 2017-08-23 | 2.55 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacrylamide (JLJ684), a Non-nucleoside Inhibitor |
5TXO | 2017-04-05 | 2.55 | STRUCTURE OF Q151M complex (A62V, V75I, F77L, F116Y, Q151M) mutant HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP |
6P1X | 2019-07-24 | 2.55 | Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and L-ddCTP |
1RT1 | 1997-04-21 | 2.55 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH MKC-442 |
5VQT | 2017-08-23 | 2.56 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 2-chloro-N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacetamide (JLJ686), a Non-nucleoside Inhibitor |
4NCG | 2014-02-12 | 2.58 | Discovery of Doravirine, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses |
5VQV | 2017-08-23 | 2.58 | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacrylamide (JLJ684), a Non-nucleoside Inhibitor |
6ANQ | 2018-08-15 | 2.59 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 8.5 |
3FFI | 2009-12-15 | 2.6 | HIV-1 RT with pyridone non-nucleoside inhibitor |
6AN8 | 2018-08-15 | 2.6 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 8.0 |
1TKT | 2004-12-07 | 2.6 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW426318 |
2ITG | 1997-03-12 | 2.6 | CATALYTIC DOMAIN OF HIV-1 INTEGRASE: ORDERED ACTIVE SITE IN THE F185H CONSTRUCT |
3T19 | 2011-10-26 | 2.6 | Crystal structure of HIV-1 reverse transcriptase (wild type) in complex with inhibitor M05 |
4ZHR | 2015-11-11 | 2.6 | Structure of HIV-1 RT Q151M mutant |
1S9E | 2004-05-11 | 2.6 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R129385 |
6IKA | 2019-01-30 | 2.6 | HIV-1 reverse transcriptase with Q151M/G112S/D113A/Y115F/F116Y/F160L/I159L:DNA:entecavir-triphosphate ternary complex |
5C24 | 2015-07-29 | 2.6 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 7-((4-((4-cyanophenyl)amino)-1,3,5-triazin-2-yl)amino)-6,8-dimethylindolizine-2-carbonitrile (JLJ605), a non-nucleoside inhibitor |
1S1V | 2004-06-29 | 2.6 | Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with TNK-651 |
6AXX | 2018-09-12 | 2.6 | Structure of the T58A/I124A mutant of the HIV-1 capsid protein |
2R02 | 2007-12-18 | 2.6 | Crystal Structure of ALIX/AIP1 in complex with the HIV-1 YPLTSL Late Domain |
1JLF | 2001-10-03 | 2.6 | CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE |
1JLG | 2001-10-03 | 2.6 | CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH UC-781 |
1FB7 | 2000-12-13 | 2.6 | CRYSTAL STRUCTURE OF AN IN VIVO HIV-1 PROTEASE MUTANT IN COMPLEX WITH SAQUINAVIR: INSIGHTS INTO THE MECHANISMS OF DRUG RESISTANCE |
1BAJ | 1998-10-14 | 2.6 | HIV-1 CAPSID PROTEIN C-TERMINAL FRAGMENT PLUS GAG P2 DOMAIN |
5XN0 | 2018-02-07 | 2.6 | HIV-1 reverse transcriptase Q151M:DNA binary complex |
4WYM | 2014-12-17 | 2.6 | Structural basis of HIV-1 capsid recognition by CPSF6 |
5VQU | 2017-08-23 | 2.6 | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-2-fluoro-N-methylacetamide (JLJ683), a Non-nucleoside Inhibitor |
1REV | 1996-10-14 | 2.6 | HIV-1 REVERSE TRANSCRIPTASE |
3DRP | 2008-10-14 | 2.6 | HIV reverse transcriptase in complex with inhibitor R8e |
6AVT | 2018-08-15 | 2.6 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 9.5 WITH CROSS-LINKING TO FIRST BASE TEMPLATE OVERHANG |
1A43 | 1999-02-09 | 2.6 | STRUCTURE OF THE HIV-1 CAPSID PROTEIN DIMERIZATION DOMAIN AT 2.6A RESOLUTION |
6B2H | 2018-09-26 | 2.6 | P38A/T216I mutant of the HIV-1 capsid protein |
3QO9 | 2011-05-04 | 2.6 | Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with TSAO-T, a non-nucleoside RT inhibitor (NNRTI) |
6ASW | 2018-08-15 | 2.61 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 9.0 |
6GL1 | 2018-08-08 | 2.62 | HLA-E*01:03 in complex with the HIV epitope, RL9HIV |
1LWC | 2002-10-30 | 2.62 | CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE |
4RW6 | 2015-04-29 | 2.63 | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) variant in complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor |
5EU7 | 2016-09-28 | 2.64 | Crystal structure of HIV-1 integrase catalytic core in complex with Fab |
4DGC | 2012-02-08 | 2.65 | TRIMCyp cyclophilin domain from Macaca mulatta: cyclosporin A complex |
4GW6 | 2013-05-01 | 2.65 | HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor |
3DI6 | 2008-08-19 | 2.65 | HIV-1 RT with pyridazinone non-nucleoside inhibitor |
6BSH | 2018-01-03 | 2.65 | Structure of HIV-1 RT complexed with RNA/DNA hybrid in the RNA hydrolysis mode |
2B6A | 2005-11-01 | 2.65 | Crystal structure of HIV-1 reverse transcriptase (RT) in complex with THR-50 |
3KLI | 2010-09-22 | 2.65 | Crystal structure of unliganded AZT-resistant HIV-1 Reverse Transcriptase |
1KLM | 1998-03-18 | 2.65 | HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH BHAP U-90152 |
6OUN | 2019-07-24 | 2.66 | Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (-)3TC-TP |
4RW4 | 2015-04-29 | 2.67 | Crystal Structure of HIV-1 Reverse Transcriptase (K103N,Y181C) variant in complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor |
5KGX | 2016-10-19 | 2.67 | HIV1 catalytic core domain in complex with an inhibitor (2~{S})-2-[3-(3,4-dihydro-2~{H}-chromen-6-yl)-1-methyl-indol-2-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid |
3M8P | 2010-05-19 | 2.67 | HIV-1 RT with NNRTI TMC-125 |
4KSE | 2014-08-13 | 2.68 | Crystal structure of a HIV p51 (219-230) deletion mutant |
6BHT | 2018-08-01 | 2.69 | HIV-1 CA hexamer in complex with IP6, orthorhombic crystal form |
4LSL | 2013-12-25 | 2.69 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-(4-chloro-2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ476), a non-nucleoside inhibitor |
3PHV | 1992-01-15 | 2.7 | X-RAY ANALYSIS OF HIV-1 PROTEINASE AT 2.7 ANGSTROMS RESOLUTION CONFIRMS STRUCTURAL HOMOLOGY AMONG RETROVIRAL ENZYMES |
1C0T | 2000-07-19 | 2.7 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+21.1326 |
1HQE | 2001-05-30 | 2.7 | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 |
5TER | 2017-01-11 | 2.7 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-chloro-7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-8-methyl-2-naphthonitrile (JLJ651), a Non-nucleoside Inhibitor |
5TUQ | 2017-06-28 | 2.7 | Crystal Structure of a 6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione Inhibitor in Complex with HIV Reverse Transcriptase |
1S1W | 2004-06-29 | 2.7 | Crystal structure of V106A mutant HIV-1 reverse transcriptase in complex with UC-781 |
3GGX | 2009-05-26 | 2.7 | HIV Protease, pseudo-symmetric inhibitors |
3C6T | 2008-04-22 | 2.7 | Crystal Structure of HIV Reverse Transcriptase in complex with inhibitor 14 |
3QLH | 2011-12-21 | 2.7 | HIV-1 Reverse Transcriptase in Complex with Manicol at the RNase H Active Site and TMC278 (Rilpivirine) at the NNRTI Binding Pocket |
6AN2 | 2018-08-15 | 2.7 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 7.5 |
3DS3 | 2008-09-02 | 2.7 | HIV-1 capsid C-terminal domain mutant (Y169A) in complex with an inhibitor of particle assembly (CAI) |
3KK1 | 2010-03-23 | 2.7 | HIV-1 reverse transcriptase-DNA complex with nuceotide inhibitor GS-9148-diphosphate bound in nucleotide site |
3M8Q | 2010-05-19 | 2.7 | HIV-1 RT with AMINOPYRIMIDINE NNRTI |
4XFZ | 2015-06-10 | 2.7 | Structure of the native full-length HIV-1 capsid protein in complex with PF-3450074 (PF74) |
3H4E | 2009-06-23 | 2.7 | X-ray Structure of Hexameric HIV-1 CA |
3I0S | 2009-08-25 | 2.7 | crystal structure of HIV reverse transcriptase in complex with inhibitor 7 |
5TXM | 2017-04-05 | 2.7 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DDATP |
3C6U | 2008-04-22 | 2.7 | Crystal Structure of HIV Reverse Transcriptase in complex with inhibitor 22 |
2FDE | 2006-02-21 | 2.7 | Wild type HIV protease bound with GW0385 |
3V6D | 2012-01-18 | 2.7 | Crystal structure of HIV-1 reverse transcriptase (RT) cross-linked with AZT-terminated DNA |
1HHP | 1992-10-15 | 2.7 | THE THREE-DIMENSIONAL STRUCTURE OF THE ASPARTYL PROTEASE FROM THE HIV-1 ISOLATE BRU |
1HQU | 2001-05-30 | 2.7 | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 |
1DLO | 1996-08-01 | 2.7 | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 |
4I2Q | 2013-01-16 | 2.7 | Crystal structure of K103N/Y181C mutant of HIV-1 reverse transcriptase in complex with rilpivirine (TMC278) analogue |
5TXP | 2017-04-05 | 2.7 | STRUCTURE OF Q151M complex (A62V, V75I, F77L, F116Y, Q151M) mutant HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DDATP |
4O4G | 2014-11-05 | 2.71 | Crystal Structure of HIV-1 Reverse Transcriptase in complex with 4-((4-(mesitylamino)-1,3,5-triazin-2-yl)amino)benzonitrile (JLJ527), a non-nucleoside inhibitor |
1EET | 2001-02-07 | 2.73 | HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH THE INHIBITOR MSC204 |
6DTW | 2019-07-31 | 2.74 | HIV-1 Reverse Transcriptase Y181C Mutant in complex with JLJ 578 |
6P1I | 2019-07-24 | 2.74 | Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and dCTP |
5NMG | 2017-11-15 | 2.75 | 868 TCR in complex with HLA A02 presenting SLYFNTIAVL |
5HRO | 2016-06-01 | 2.75 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A DNA aptamer and an Alpha-carboxy nucleoside phosphonate inhibitor (alpha-CNP) |
6CQJ | 2018-06-06 | 2.75 | Crystal structure of DR1 presenting the RQ13 peptide |
3LAM | 2010-02-23 | 2.76 | Crystal structure of HIV-1 reverse transcriptase in complex with N1-propyl pyrimidinedione non-nucleoside inhibitor |
5O2U | 2017-06-21 | 2.76 | Llama VHH in complex with p24 |
6AXV | 2018-09-12 | 2.77 | Structure of the T58S/T107I/P122A mutant of the HIV-1 capsid protein in complex with PF-3450074 (PF74) |
6AXY | 2018-09-12 | 2.78 | Structure of the V11I/T58A/I124A mutant of the HIV-1 capsid protein |
5XOT | 2017-06-14 | 2.79 | Crystal structure of pHLA-B35 in complex with TU55 T cell receptor |
5J2Q | 2016-08-03 | 2.79 | HIV-1 reverse transcriptase in complex with DNA that has incorporated a mismatched EFdA-MP at the N-(pre-translocation) site |
3LP0 | 2010-06-09 | 2.79 | HIV-1 reverse transcriptase with inhibitor |
4DQG | 2012-03-07 | 2.79 | Crystal Structure of apo(G16C/L38C) HIV-1 Protease |
1HTE | 1994-07-31 | 2.8 | X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE |
4XFY | 2015-06-10 | 2.8 | Structure of the native full-length dehydrated HIV-1 capsid protein |
1LWF | 2002-10-30 | 2.8 | CRYSTAL STRUCTURE OF A MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMQ+M184V: M41L/D67N/K70R/M184V/T215Y) IN COMPLEX WITH NEVIRAPINE |
1M63 | 2002-09-25 | 2.8 | Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes |
9HVP | 1992-04-15 | 2.8 | Design, activity and 2.8 Angstroms crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease |
4U0B | 2014-11-12 | 2.8 | Hexamer HIV-1 CA in complex with CPSF6 peptide, P212121 crystal form |
1EX4 | 2000-06-07 | 2.8 | HIV-1 INTEGRASE CATALYTIC CORE AND C-TERMINAL DOMAIN |
1IKX | 2001-06-06 | 2.8 | K103N Mutant HIV-1 Reverse Transcriptase in Complex with the Inhibitor PNU142721 |
2BPX | 1999-02-23 | 2.8 | HIV-1 protease-inhibitor complex |
1TV6 | 2004-07-20 | 2.8 | HIV-1 Reverse Transcriptase Complexed with CP-94,707 |
3LP3 | 2010-06-09 | 2.8 | p15 HIV RNaseH domain with inhibitor MK3 |
3ITH | 2010-03-16 | 2.8 | Crystal structure of the HIV-1 reverse transcriptase bound to a 6-vinylpyrimidine inhibitor |
3LP2 | 2010-06-09 | 2.8 | HIV-1 reverse transcriptase with inhibitor |
1BDR | 1998-10-14 | 2.8 | HIV-1 (2: 31, 33-37) PROTEASE COMPLEXED WITH INHIBITOR SB203386 |
2OPQ | 2007-05-22 | 2.8 | Crystal Structure of L100I Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X. |
1BDL | 1998-08-12 | 2.8 | HIV-1 (2:31-37) PROTEASE COMPLEXED WITH INHIBITOR SB203386 |
1HNI | 1995-06-03 | 2.8 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN A COMPLEX WITH THE NONNUCLEOSIDE INHIBITOR ALPHA-APA R 95845 AT 2.8 ANGSTROMS RESOLUTION |
3HVP | 1989-10-15 | 2.8 | CONSERVED FOLDING IN RETROVIRAL PROTEASES. CRYSTAL STRUCTURE OF A SYNTHETIC HIV-1 PROTEASE |
1LW0 | 2002-10-30 | 2.8 | CRYSTAL STRUCTURE OF T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE |
1S1X | 2004-06-29 | 2.8 | Crystal structure of V108I mutant HIV-1 reverse transcriptase in complex with nevirapine |
2BPW | 1999-02-23 | 2.8 | HIV-1 protease-inhibitor complex |
3S85 | 2012-04-11 | 2.8 | Discovery of New HIV Protease Inhibitors with Potential for Convenient Dosing and Reduced Side Effects: A-790742 and A-792611. |
6CQQ | 2018-06-06 | 2.8 | Crystal structure of F24 TCR -DR15-RQ13 peptide complex |
3IRX | 2010-04-07 | 2.8 | Crystal Structure of HIV-1 reverse transcriptase (RT) in complex with the Non-nucleoside RT Inhibitor (E)-S-Methyl 5-(1-(3,7-Dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-5-(5-methyl-1,3,4-oxadiazol-2-yl)pent-1-enyl)-2-methoxy-3-methylbenzothioate. |
1DTQ | 2000-03-20 | 2.8 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-1 (PETT131A94) |
2HMI | 1998-10-14 | 2.8 | HIV-1 REVERSE TRANSCRIPTASE/FRAGMENT OF FAB 28/DNA COMPLEX |
2WON | 2010-08-11 | 2.8 | Crystal Structure of UK-453061 bound to HIV-1 Reverse Transcriptase (wild-type). |
3MEG | 2010-05-12 | 2.8 | HIV-1 K103N Reverse Transcriptase in Complex with TMC278 |
1RDH | 1994-05-31 | 2.8 | CRYSTALLOGRAPHIC ANALYSES OF AN ACTIVE HIV-1 RIBONUCLEASE H DOMAIN SHOW STRUCTURAL FEATURES THAT DISTINGUISH IT FROM THE INACTIVE FORM |
1JLE | 2001-10-03 | 2.8 | CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE |
1S9G | 2004-05-11 | 2.8 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R120394. |
3D3T | 2008-07-08 | 2.8 | Crystal Structure of HIV-1 CRF01_AE in complex with the substrate p1-p6 |
1TL3 | 2004-12-07 | 2.8 | Crystal structure of hiv-1 reverse transcriptase in complex with gw450557 |
3IG1 | 2010-01-26 | 2.8 | HIV-1 Reverse Transcriptase with the Inhibitor beta-Thujaplicinol Bound at the RNase H Active Site |
3V4I | 2012-01-18 | 2.8 | Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and AZTTP |
1R0A | 2004-08-03 | 2.8 | Crystal structure of HIV-1 reverse transcriptase covalently tethered to DNA template-primer solved to 2.8 angstroms |
1RT6 | 1999-07-29 | 2.8 | HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC38 |
2VG5 | 2007-12-11 | 2.8 | Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors |
1TKZ | 2004-12-07 | 2.81 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW429576 |
1LWE | 2002-10-30 | 2.81 | CRYSTAL STRUCTURE OF M41L/T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMN) IN COMPLEX WITH NEVIRAPINE |
6BHJ | 2018-10-31 | 2.81 | Structure of HIV-1 Reverse Transcriptase Bound to a 38-mer Hairpin Template-Primer RNA-DNA Aptamer |
2VG7 | 2007-12-11 | 2.82 | Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors |
5C25 | 2015-07-29 | 2.84 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 6-((4-((4-cyanophenyl)amino)-1,3,5-triazin-2-yl)amino)-5,7-dimethyl-2-naphthonitrile (JLJ639), a Non-nucleoside Inhibitor |
4H4M | 2012-12-05 | 2.85 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor |
3V81 | 2012-01-18 | 2.85 | Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and the nonnucleoside inhibitor nevirapine |
1QE1 | 1999-08-30 | 2.85 | CRYSTAL STRUCTURE OF 3TC-RESISTANT M184I MUTANT OF HIV-1 REVERSE TRANSCRIPTASE |
1TKX | 2004-12-07 | 2.85 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745 |
5TW3 | 2017-03-15 | 2.85 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)-4-fluorophenoxy)-7-fluoro-2-naphthonitrile (JLJ636), a Non-nucleoside Inhibitor |
6OTZ | 2019-07-24 | 2.86 | Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (+)FTC-TP |
5V5M | 2017-06-14 | 2.88 | Crystal structure of HLA-B*5701 complex with HIV-1 gag derived peptide TW10 |
5INC | 2016-10-05 | 2.88 | Crystal structure of HLA-B5801, a protective HLA allele for HIV-1 infection |
4RW8 | 2015-04-29 | 2.88 | Crystal Structure of HIV-1 Reverse Transcriptase in complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ532), a non-nucleoside inhibitor' |
4MFB | 2013-11-06 | 2.88 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)indolizine-2-carbonitrile (JLJ555), a non-nucleoside inhibitor |
6BSJ | 2018-01-03 | 2.89 | Structure of HIV-1 RT complexed with an RNA/DNA hybrid sequence non-preferred for RNA hydrolysis |
4R5P | 2015-03-11 | 2.89 | Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and a nucleoside triphosphate mimic alpha-carboxy nucleoside phosphonate inhibitor |
4O44 | 2014-05-21 | 2.89 | Crystal Structure of HIV-1 Reverse Transcriptase in complex with 4-((4-(mesitylamino)-6-(3-morpholinopropoxy)-1,3,5-triazin-2-yl)amino)benzonitrile (JLJ529), a non-nucleoside inhibitor |
5NMF | 2017-11-15 | 2.89 | 868 TCR in complex with HLA A02 presenting SLYNTIATL |
3DRR | 2008-10-14 | 2.89 | HIV reverse transcriptase Y181C mutant in complex with inhibitor R8e |
4KKO | 2013-08-14 | 2.89 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 4-((4-methoxy-6-(2-morpholinoethoxy)-1,3,5-triazin-2-yl)amino)-2-((3-methylbut-2-en-1-yl)oxy)benzonitrile (JLJ513), a non-nucleoside inhibitor |
1TL1 | 2004-12-07 | 2.9 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW451211 |
6OE3 | 2019-05-15 | 2.9 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-7-fluoro-2-naphthonitrile (JLJ635), a Non-nucleoside Inhibitor |
2YNH | 2013-01-09 | 2.9 | HIV-1 Reverse Transcriptase in complex with inhibitor GSK500 |
3HVT | 1994-10-15 | 2.9 | STRUCTURAL BASIS OF ASYMMETRY IN THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE HETERODIMER |
1FKP | 2000-11-03 | 2.9 | CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE |
1S6P | 2004-05-11 | 2.9 | CRYSTAL STRUCTURE OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R100943 |
3DOK | 2008-08-12 | 2.9 | Crystal structure of K103N mutant HIV-1 reverse transcriptase in complex with GW678248. |
2ZE2 | 2008-02-12 | 2.9 | Crystal structure of L100I/K103N mutant HIV-1 reverse transcriptase (RT) in complex with TMC278 (rilpivirine), a non-nucleoside RT inhibitor |
5J1E | 2016-06-15 | 2.9 | Crystal Structure of a Hydroxypyridone Carboxylic Acid Active-Site RNase H Inhibitor in Complex with HIV Reverse Transcriptase |
5J2N | 2016-08-03 | 2.9 | HIV-1 reverse transcriptase in complex with DNA that has incorporated EFdA-MP at the P-(post-translocation) site and dTMP at the N-(pre-translocation) site |
1FKO | 2000-11-03 | 2.9 | CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ) |
3KK2 | 2010-03-23 | 2.9 | HIV-1 reverse transcriptase-DNA complex with dATP bound in the nucleotide binding site |
1RT4 | 1999-07-29 | 2.9 | HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC781 |
2B5J | 2005-12-06 | 2.9 | Crystal structure of HIV-1 reverse transcriptase (RT) in complex with JANSSEN-R165481 |
5HP1 | 2016-06-01 | 2.9 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A DNA aptamer and FOSCARNET, a Pyrophosphate analog |
3KK3 | 2010-03-23 | 2.9 | HIV-1 reverse transcriptase-DNA complex with GS-9148 terminated primer |
4PUO | 2014-06-18 | 2.9 | Crystal structure of HIV-1 reverse transcriptase in complex with RNA/DNA and Nevirapine |
2YKM | 2011-08-17 | 2.9 | Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with a Difluoromethylbenzoxazole (DFMB) Pyrimidine Thioether derivative, a non-nucleoside RT inhibitor (NNRTI) |
1SV5 | 2004-05-11 | 2.9 | CRYSTAL STRUCTURE OF K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R165335 |
3KLH | 2010-09-22 | 2.9 | Crystal structure of AZT-Resistant HIV-1 Reverse Transcriptase crosslinked to post-translocation AZTMP-Terminated DNA (COMPLEX P) |
1RT5 | 1999-07-29 | 2.9 | HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC10 |
4H4O | 2012-12-05 | 2.9 | Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with (E)-3-(3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)- 4-fluorophenoxy)-5-fluorophenyl)acrylonitrile (JLJ506), A Non-nucleoside inhibitor |
2OPR | 2007-05-22 | 2.9 | Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X. |
1KJ4 | 2002-03-06 | 2.9 | SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES |
6BHR | 2018-08-08 | 2.91 | HIV-1 immature CTD-SP1 hexamer in complex with IP6 |
5NME | 2017-11-15 | 2.94 | 868 TCR in complex with HLA A02 presenting SLYNTVATL |
5HLF | 2016-02-10 | 2.95 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A 38-MER HAIRPIN TEMPLATE-PRIMER DNA APTAMER AND AN ALPHA-CARBOXYPHOSPHONATE INHIBITOR |
2BAN | 2005-12-06 | 2.95 | Crystal structure of HIV-1 reverse transcriptase (RT) in complex with JANSSEN-R157208 |
3E01 | 2008-11-25 | 2.95 | HIV-RT with non-nucleoside inhibitor annulated pyrazole 2 |
3NBP | 2010-08-18 | 2.95 | HIV-1 reverse transcriptase with aminopyrimidine inhibitor 2 |
3I0R | 2009-08-25 | 2.98 | crystal structure of HIV reverse transcriptase in complex with inhibitor 3 |
4RW9 | 2015-04-29 | 2.99 | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) variant in complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ532), a non-nucleoside inhibitor |
6P2G | 2019-07-24 | 2.99 | Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and D-ddCTP |
1DTT | 2000-04-02 | 3.0 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-2 (PETT130A94) |
1AUM | 1998-01-14 | 3.0 | HIV CAPSID C-TERMINAL DOMAIN (CAC146) |
2HVP | 1989-04-19 | 3.0 | THREE-DIMENSIONAL STRUCTURE OF ASPARTYL PROTEASE FROM HUMAN IMMUNODEFICIENCY VIRUS HIV-1 |
1S6Q | 2004-05-11 | 3.0 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R147681 |
1LW2 | 2002-10-30 | 3.0 | CRYSTAL STRUCTURE OF T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH 1051U91 |
2HNZ | 2006-09-05 | 3.0 | Crystal Structure of E138K Mutant HIV-1 Reverse Transcriptase in Complex with PETT-2 |
1JLQ | 2001-08-22 | 3.0 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH 739W94 |
5I3U | 2016-06-01 | 3.0 | STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE N-SITE COMPLEX; CATALYTIC INCORPORATION OF AZTMP to A DNA aptamer in CRYSTAL |
1T05 | 2004-05-11 | 3.0 | HIV-1 reverse transcriptase crosslinked to template-primer with tenofovir-diphosphate bound as the incoming nucleotide substrate |
1JLB | 2001-10-03 | 3.0 | CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE |
1SUQ | 2004-05-11 | 3.0 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R185545 |
3JSM | 2009-09-29 | 3.0 | K65R mutant HIV-1 reverse transcriptase cross-linked to DS-DNA and complexed with tenofovir-diphosphate as the incoming nucleotide substrate |
1RT7 | 1999-07-29 | 3.0 | HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC84 |
6N3J | 2018-12-12 | 3.0 | MicroED Structure of the CTD-SP1 fragment of HIV-1 Gag |
1IKV | 2001-06-06 | 3.0 | K103N Mutant HIV-1 Reverse Transcriptase in Complex with Efivarenz |
1RTI | 1996-04-03 | 3.0 | HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES |
1JLC | 2001-10-03 | 3.0 | CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-2 |
1HPZ | 2001-05-30 | 3.0 | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 |
1RT3 | 1999-02-16 | 3.0 | AZT DRUG RESISTANT HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH 1051U91 |
1HYS | 2001-03-26 | 3.0 | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A POLYPURINE TRACT RNA:DNA |
1E28 | 2000-09-12 | 3.0 | Nonstandard peptide binding of HLA-B*5101 complexed with HIV immunodominant epitope KM2(TAFTIPSI) |
4PWD | 2014-06-18 | 3.0 | Crystal structure of HIV-1 reverse transcriptase in complex with bulge-RNA/DNA and Nevirapine |
1N6Q | 2003-01-14 | 3.0 | HIV-1 Reverse Transcriptase Crosslinked to pre-translocation AZTMP-terminated DNA (complex N) |
1S1U | 2004-06-29 | 3.0 | Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with nevirapine |
5W5W | 2018-06-20 | 3.0 | HIV Protease (PR) in open form with Mg2+ in active site and HIVE-9 in eye site |
2IC3 | 2006-12-19 | 3.0 | Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with Nonnucleoside Inhibitor HBY 097 |
2UPJ | 1996-10-14 | 3.0 | HIV-1 PROTEASE COMPLEX WITH U100313 ([3-[[3-[CYCLOPROPYL [4-HYDROXY-2OXO-6-[1-(PHENYLMETHYL)PROPYL]-2H-PYRAN-3-YL] METHYL]PHENYL]AMINO]-3-OXO-PROPYL]CARBAMIC ACID TERT-BUTYL ESTER) |
1TVR | 1997-03-12 | 3.0 | HIV-1 RT/9-CL TIBO |
4U0D | 2014-11-12 | 3.0 | Hexameric HIV-1 CA in complex with Nup153 peptide, P212121 crystal form |
1HNV | 1995-07-10 | 3.0 | STRUCTURE OF HIV-1 RT(SLASH)TIBO R 86183 COMPLEX REVEALS SIMILARITY IN THE BINDING OF DIVERSE NONNUCLEOSIDE INHIBITORS |
1IKW | 2001-06-06 | 3.0 | Wild Type HIV-1 Reverse Transcriptase in Complex with Efavirenz |
1YT9 | 2005-04-12 | 3.0 | HIV Protease with oximinoarylsulfonamide bound |
5UV5 | 2017-08-16 | 3.0 | Crystal Structure of a 2-Hydroxyisoquinoline-1,3-dione RNase H Active Site Inhibitor with Multiple Binding Modes to HIV Reverse Transcriptase |
1IKY | 2001-06-06 | 3.0 | HIV-1 Reverse Transcriptase in Complex with the Inhibitor MSC194 |
4RW7 | 2015-04-29 | 3.01 | Crystal Structure of HIV-1 Reverse Transcriptase (K103N, Y181C) variant in complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ532), a non-nucleoside inhibitor |
2VG6 | 2007-12-11 | 3.01 | Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors |
6CQR | 2018-06-06 | 3.04 | Crystal structure of F24 TCR -DR1-RQ13 peptide complex |
5HBM | 2016-02-24 | 3.04 | Crystal Structure of a Dihydroxycoumarin RNase H Active-Site Inhibitor in Complex with HIV-1 Reverse Transcriptase |
3GGV | 2009-05-26 | 3.09 | HIV Protease, pseudo-symmetric inhibitors |
1FQX | 2001-03-14 | 3.1 | CRYSTAL STRUCTURE OF THE COMPLEX OF HIV-1 PROTEASE WITH A PEPTIDOMIMETIC INHIBITOR |
1N5Y | 2003-01-28 | 3.1 | HIV-1 Reverse Transcriptase Crosslinked to Post-Translocation AZTMP-Terminated DNA (Complex P) |
5HGL | 2016-08-10 | 3.1 | Hexameric HIV-1 CA, open conformation |
5FDL | 2016-02-17 | 3.1 | Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with IDX899 |
3KJV | 2010-03-23 | 3.1 | HIV-1 reverse transcriptase in complex with DNA |
1BQM | 1999-01-06 | 3.1 | HIV-1 RT/HBY 097 |
3W39 | 2013-02-13 | 3.1 | Crystal structure of HLA-B*5201 in complexed with HIV immunodominant epitope (TAFTIPSI) |
1MF8 | 2002-10-16 | 3.1 | Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin |
1T03 | 2004-05-11 | 3.1 | HIV-1 reverse transcriptase crosslinked to tenofovir terminated template-primer (complex P) |
4LSN | 2013-12-25 | 3.1 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-bromo-5-(4-chloro-2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ518), a non-nucleoside inhibitor |
5TEP | 2017-01-11 | 3.1 | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ649), a Non-nucleoside Inhibitor |
3KLF | 2010-09-22 | 3.15 | Crystal structure of wild-type HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA |
3DRS | 2008-10-14 | 3.15 | HIV reverse transcriptase K103N mutant in complex with inhibitor R8D |
2I5J | 2006-12-05 | 3.15 | Crystal structure of HIV-1 reverse transcriptase (RT) in complex with DHBNH, an RNASE H inhibitor |
2WOM | 2010-08-11 | 3.2 | Crystal Structure of UK-453061 bound to HIV-1 Reverse Transcriptase (K103N). |
3KLE | 2010-09-22 | 3.2 | Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA |
1RTD | 1998-12-09 | 3.2 | STRUCTURE OF A CATALYTIC COMPLEX OF HIV-1 REVERSE TRANSCRIPTASE: IMPLICATIONS FOR NUCLEOSIDE ANALOG DRUG RESISTANCE |
6MQA | 2019-06-19 | 3.2 | Structure of HIV-1 CA P207S |
1HMV | 1995-03-31 | 3.2 | THE STRUCTURE OF UNLIGANDED REVERSE TRANSCRIPTASE FROM THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 |
6MQO | 2019-06-19 | 3.2 | Structure of HIV-1 CA G208R |
1UWB | 1997-05-15 | 3.2 | TYR 181 CYS HIV-1 RT/8-CL TIBO |
6BSI | 2018-01-03 | 3.25 | Structure of HIV-1 RT complexed with an RNA/DNA hybrid containing the polypurine-tract sequence |
4B3O | 2013-01-16 | 3.3 | Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface |
6MQP | 2019-06-19 | 3.3 | Structure of HIV-1 CA T210K |
5I42 | 2016-06-01 | 3.3 | Structure of HIV-1 Reverse Transcriptase in complex with a DNA aptamer, AZTTP, and CA(2+) ion |
4Q0B | 2014-06-18 | 3.3 | Crystal structure of HIV-1 reverse transcriptase in complex with gap-RNA/DNA and Nevirapine |
3JYT | 2009-10-06 | 3.3 | K65R mutant HIV-1 reverse transcriptase cross-linked to DS-DNA and complexed with DATP as the incoming nucleotide substrate |
1BQN | 1999-01-06 | 3.3 | TYR 188 LEU HIV-1 RT/HBY 097 |
6DTX | 2019-07-31 | 3.33 | Wildtype HIV-1 Reverse Transcriptase in complex with JLJ 578 |
6BJ2 | 2018-07-25 | 3.35 | TCR589 in complex with HIV(Pol448-456)/HLA-B35 |
1P7Q | 2003-10-14 | 3.4 | Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor |
6EC2 | 2019-08-21 | 3.4 | Structure of HIV-1 CA 1/3-hexamer |
6ECN | 2019-08-21 | 3.4 | HIV-1 CA 1/2-hexamer-EE |
1J5O | 2002-06-14 | 3.5 | CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE-PRIMER |
5C42 | 2015-11-11 | 3.5 | Crystal Structure of HIV-1 Reverse Transcriptase (K101P) Variant in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)indolizine-2-carbonitrile (JLJ555), a non-nucleoside inhibitor |
3KLG | 2010-09-22 | 3.65 | Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to pre-translocation AZTMP-Terminated DNA (COMPLEX N) |
1AFV | 1997-08-20 | 3.7 | HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3 |
5L93 | 2016-07-13 | 3.9 | An atomic model of HIV-1 CA-SP1 reveals structures regulating assembly and maturation |
5U1C | 2017-01-11 | 3.9 | Structure of tetrameric HIV-1 Strand Transfer Complex Intasome |
6HAK | 2019-04-03 | 3.95 | Crystal structure of HIV-1 reverse transcriptase (RT) in complex with a double stranded RNA represents the RT transcription initiation complex prior to nucleotide incorporation |
3DTJ | 2008-09-02 | 4.0 | HIV-1 capsid C-terminal domain mutant (E187A) |
6ECO | 2019-09-18 | 4.2 | Hexamer-2-Foldon HIV-1 capsid platform |
6B19 | 2018-04-25 | 4.5 | Architecture of HIV-1 reverse transcriptase initiation complex core |
1HVU | 1999-01-13 | 4.75 | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE COMPLEXED WITH A 33-BASE NUCLEOTIDE RNA PSEUDOKNOT |
4B3P | 2013-01-16 | 4.84 | Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface |
4B3Q | 2013-01-16 | 5.0 | Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface |
5UPW | 2017-03-01 | 5.0 | CryoEM Structure Refinement by Integrating NMR Chemical Shifts with Molecular Dynamics Simulations |
5KP9 | 2016-12-07 | 5.7 | Structure of Nanoparticle Released from Enveloped Protein Nanoparticle |
3P0A | 2011-01-12 | 5.95 | X-ray structure of pentameric HIV-1 CA |
3GV2 | 2009-06-23 | 7.0 | X-ray Structure of Hexameric HIV-1 CA |
5FJB | 2016-03-16 | 9.0 | Cyclophilin A Stabilize HIV-1 Capsid through a Novel Non- canonical Binding Site |
Percent Identity | Matching Chains | Protein | Accession | Entry Name |
---|---|---|---|---|
200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P62938 | PPIA_CHLAE |
200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q0ZQL0 | PPIA_GORGO |
200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P62937 | PPIA_HUMAN |
200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q0ZQK8 | PPIA_HYLLA |
200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P62940 | PPIA_MACMU |
200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q0ZQK7 | PPIA_NOMLE |
200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q0ZQL2 | PPIA_PANPA |
200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q0ZQL1 | PPIA_PANTR |
200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P62941 | PPIA_PAPAN |
200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q5R8S7 | PPIA_PONPY |
200.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q0ZQK6 | PPIA_SYMSY |
197.6 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P62935 | PPIA_BOVIN |
197.6 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P62936 | PPIA_PIG |
197.6 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q6DTV9 | PPIA_AOTTR |
197.6 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q0ZQK3 | PPIA_SAGOE |
194.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q8HXS3 | PPIA_FELCA |
194.0 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P14851 | PPIA_CRIGR |
192.6 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9TTC6 | PPIA_RABIT |
192.6 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P17742 | PPIA_MOUSE |
192.6 | A,B | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P10111 | PPIA_RAT |
200.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P12493 | GAG_HV1N5 |
200.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P12497 | POL_HV1N5 |
198.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P05890 | GAG_HV1RH |
198.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P05889 | GAG_HV1W2 |
198.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P35962 | GAG_HV1Y2 |
198.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P05959 | POL_HV1RH |
198.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P35963 | POL_HV1Y2 |
197.2 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P20873 | GAG_HV1JR |
197.2 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P20875 | POL_HV1JR |
197.2 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P03349 | GAG_HV1A2 |
197.2 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P03369 | POL_HV1A2 |
195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P03347 | GAG_HV1B1 |
195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P04593 | GAG_HV1B5 |
195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P03348 | GAG_HV1BR |
195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P04591 | GAG_HV1H2 |
195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q70622 | GAG_HV1LW |
195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P03366 | POL_HV1B1 |
195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P04587 | POL_HV1B5 |
195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P03367 | POL_HV1BR |
195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P04585 | POL_HV1H2 |
195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P0C6F2 | POL_HV1LW |
195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P05888 | GAG_HV1MN |
195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P20889 | GAG_HV1OY |
195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P20892 | POL_HV1OY |
194.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P05887 | GAG_HV1C4 |
195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P12495 | GAG_HV1Z2 |
194.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P05960 | POL_HV1C4 |
194.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P05961 | POL_HV1MN |
195.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P12499 | POL_HV1Z2 |
194.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q73367 | GAG_HV1B9 |
194.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q73368 | POL_HV1B9 |
194.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P04592 | GAG_HV1EL |
194.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P04589 | POL_HV1EL |
193.2 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P18800 | GAG_HV1ND |
193.2 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P18802 | POL_HV1ND |
194.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P12494 | GAG_HV1J3 |
194.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P12498 | POL_HV1J3 |
189.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9WC53 | GAG_HV1S2 |
189.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9WC54 | POL_HV1S2 |
189.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9QBZ6 | GAG_HV1MP |
189.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9QBZ5 | POL_HV1MP |
187.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9QBY4 | GAG_HV196 |
187.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9QBZ2 | GAG_HV1M2 |
187.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9QBY3 | POL_HV196 |
187.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9QBZ1 | POL_HV1M2 |
186.2 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9WC62 | GAG_HV1S9 |
186.2 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9WC63 | POL_HV1S9 |
189.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9Q721 | GAG_HV1V9 |
189.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9Q720 | POL_HV1V9 |
187.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | O12157 | GAG_HV192 |
187.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | O12158 | POL_HV192 |
187.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9QC00 | GAG_HV197 |
187.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9QBZ9 | POL_HV197 |
184.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q75001 | GAG_HV1ET |
184.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P04594 | GAG_HV1MA |
184.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q75002 | POL_HV1ET |
184.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P04588 | POL_HV1MA |
184.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9QSR4 | GAG_HV1VI |
184.8 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q9QSR3 | POL_HV1VI |
187.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | O93182 | GAG_HV190 |
187.6 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | O93215 | POL_HV190 |
183.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q1A268 | GAG_SIVMB |
183.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | Q1A267 | POL_SIVMB |
183.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | O89291 | GAG_HV193 |
183.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | O89290 | POL_HV193 |
183.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P24736 | GAG_HV1U4 |
183.4 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P24740 | POL_HV1U4 |
182.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | P0C1K7 | GAG_HV19N |
182.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | O89939 | GAG_HV1SE |
182.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | O41798 | POL_HV19N |
182.0 | C,D | Peptidyl-prolyl cis-trans isomerase A,Gag-Pol polyprotein | O89940 | POL_HV1SE |