Thermal denaturation of erythrocyte carbonic anhydrase.
Abstract
An experimental study on the thermal behaviour of erythrocyte carbonic anhydrase was carried out with the main aim to estimate the thermodynamic parameters that control the stability of the enzyme. The effects of thermal denaturation on the catalytic properties of the enzyme were also investigated. Below 60 degrees C the enzyme was found to be very stable, whereas between 60 and 65 degrees C a drastic decrease in the biological activity was observed. From the obtained results some considerations were made about the stabilization of the active form of the protein. Study holds ProTherm entries: 10121, 10122 Extra Details: carbonic anhydrase; thermal denaturation; conformational stability;,bovine erythrocytes
Submission Details
ID: 35X8xCNJ4
Submitter: Connie Wang
Submission Date: April 24, 2018, 8:39 p.m.
Version: 1
Publication Details
Lavecchia R;Zugaro M,FEBS Lett. (1991) Thermal denaturation of erythrocyte carbonic anhydrase. PMID:1959599Additional Information
Study Summary
Structure view and single mutant data analysis
Study data
| Colors: | D | E | R | H | K | S | T | N | Q | A | V | I | L | M | F | Y | W | C | G | P |
|---|
Data Distribution
Studies with similar sequences (approximate matches)
Correlation with other assays (exact sequence matches)
Relevant PDB Entries
| Structure ID | Release Date | Resolution | Structure Title |
|---|---|---|---|
| 6FJJ | 2019-02-06 | Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (saccharin). | |
| 5C8I | 2016-07-20 | Joint X-ray/neutron structure of Human Carbonic Anhydrase II in complex with Methazolamide | |
| 6FJI | 2019-02-06 | Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (apo). | |
| 6QEB | 2019-02-06 | Assessment of a large enzyme-drug complex by proton-detected solid-state NMR without deuteration | |
| 6GCY | 2019-02-06 | Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (saccharin-sugar conjugate complex) | |
| 6BC9 | 2018-02-28 | Joint X-ray/neutron structure of human carbonic anhydrase II in complex with dorzolamide | |
| 3KS3 | 2010-01-26 | 0.9 | High resolution structure of Human Carbonic Anhydrase II at 0.9 A |
| 6B00 | 2017-12-13 | 0.9 | Thermostabilized mutant of human carbonic anhydrase II - A65T L100H K154N L224S L240P A248T |
| 3K34 | 2010-05-12 | 0.9 | Human carbonic anhydrase II with a sulfonamide inhibitor |
| 5Y2S | 2018-02-14 | 0.9 | 7.0 atm CO2-pressurized human carbonic anhydrase II |
| 3U7C | 2013-02-13 | 0.93 | crystal structure of the V143I mutant of human carbonic anhydrase II |
| 1LUG | 2003-09-09 | 0.95 | Full Matrix Error Analysis of Carbonic Anhydrase |
| 4YXI | 2016-02-03 | 0.96 | Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (2). |
| 4FU5 | 2013-07-17 | 0.98 | Carbonic Anhydrase II in complex with N-[(2Z)-1,3-oxazolidin-2-ylidene]sulfuric diamide |
| 4FPT | 2013-07-03 | 0.98 | Carbonic Anhydrase II in complex with ethyl (2Z,4R)-2-(sulfamoylimino)-1,3-thiazolidine-4-carboxylate |
| 4FRC | 2013-07-17 | 0.98 | Carbonic Anhydrase II in complex with N'-sulfamoylpyrrolidine-1-carboximidamide |
| 2FOU | 2006-04-04 | 0.99 | Human Carbonic Anhydrase II complexed with two-prong inhibitors |
| 5OGO | 2018-08-01 | 0.99 | Crystal structure of chimeric carbonic anhydrase I with 3-(Benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide |
| 5LJT | 2017-06-21 | 1.0 | Crystal structure of human carbonic anhydrase II in complex with the 4-((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)benzenesulfonamide inhibitor |
| 5Y2R | 2018-02-14 | 1.0 | 2.5 atm CO2-pressurized human carbonic anhydrase II |
| 4MTY | 2013-12-11 | 1.0 | Structure at 1A resolution of a helical aromatic foldamer-protein complex. |
| 4Q78 | 2015-03-18 | 1.0 | Structure-assisted design of carborane-based inhibitors of carbonic anhydrase |
| 2NNO | 2007-05-08 | 1.01 | Structure of inhibitor binding to Carbonic Anhydrase II |
| 6G3Q | 2018-11-28 | 1.01 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor famotidine |
| 4YX4 | 2016-02-03 | 1.01 | Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (1). |
| 5LL8 | 2017-08-16 | 1.03 | Human Carbonic Anhydrase II in complex with aliphatic Benzenesulfonamide inhibitor. |
| 3V7X | 2012-04-04 | 1.03 | Complex of human carbonic anhydrase II with N-[2-(3,4-dimethoxyphenyl)ethyl]-4-sulfamoylbenzamide |
| 2NNS | 2007-05-08 | 1.03 | Structure of inhibitor binding to Carbonic Anhydrase II |
| 2ILI | 2007-06-05 | 1.05 | Refine atomic structure of human carbonic anhydrase II |
| 5DOH | 2016-09-28 | 1.05 | Crystal structure of human carbonic anhydrase isozyme II with 2-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-3,5,6-trifluoro-4-[(2-hydroxyethyl)thio]benzenesulfonamide |
| 5LJQ | 2017-06-21 | 1.05 | Crystal structure of human carbonic anhydrase II in complex with the 4-(4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl)benzenesulfonamide inhibitor |
| 3VBD | 2012-04-04 | 1.05 | Complex of human carbonic anhydrase II with 4-(6-methoxy-3,4-dihydroisoquinolin-1-yl)benzenesulfonamide |
| 1MOO | 2002-09-18 | 1.05 | Site Specific Mutant (H64A) of Human Carbonic Anhydrase II at high resolution |
| 4FVN | 2013-07-17 | 1.05 | Carbonic Anhydrase II in complex with N-(tetrahydropyrimidin-2(1H)-ylidene)sulfuric diamide |
| 4FVO | 2013-07-03 | 1.05 | Carbonic Anhydrase II in complex with N-[(2E)-3,4-dihydroquinazolin-2(1H)-ylidene]sulfuric diamide |
| 4YXO | 2016-02-03 | 1.06 | Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (3). |
| 4PZH | 2015-01-28 | 1.06 | Crystal structure of human carbonic anhydrase isozyme II with 2,3,5,6-tetrafluoro-4[(2-hydroxyethyl)sulfonyl]benzenesulfonamide |
| 4WW6 | 2015-07-01 | 1.06 | Crystal structure of human carbonic anhydrase isozyme II with 2,3,5,6-Tetrafluoro-4-(propylthio)benzenesulfonamide |
| 4YYT | 2016-02-03 | 1.07 | Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (5). |
| 4Q08 | 2015-01-28 | 1.07 | Crystal structure of chimeric carbonic anhydrase XII with inhibitor |
| 5M78 | 2017-12-20 | 1.08 | Human Carbonic Anhydrase II in complex with fragment-like inhibitor. |
| 4YXU | 2016-02-03 | 1.08 | Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (4). |
| 6GDC | 2019-05-01 | 1.08 | Human Carbonic Anhydrase II in complex with Benzenesulfonamide |
| 6GM9 | 2019-06-19 | 1.09 | Human Carbonic Anhydrase II in complex with 4-Methylbenzenesulfonamide |
| 2WEG | 2009-11-10 | 1.1 | Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors |
| 5OGP | 2018-08-01 | 1.1 | Metalacarborane inhibitors of Carbonic Anhydrase IX |
| 2NNV | 2007-05-08 | 1.1 | Structure of inhibitor binding to Carbonic Anhydrase II |
| 3D93 | 2008-09-02 | 1.1 | Apo Human carbonic anhydrase II bound with substrate carbon dioxide |
| 2FOS | 2006-04-04 | 1.1 | Human Carbonic Anhydrase II complexed with two-prong inhibitors |
| 5JGT | 2017-01-11 | 1.1 | Human carbonic anhydrase II (F131Y/L198A) complexed with 1,3-thiazole-2-sulfonamide |
| 3HS4 | 2009-12-08 | 1.1 | Human carbonic anhydrase II complexed with acetazolamide |
| 5OGN | 2018-08-01 | 1.1 | Metalacarborane inhibitors of Carbonic Anhydrase IX |
| 5NXW | 2018-01-17 | 1.1 | Carbonic Anhydrase II Inhibitor RA9 |
| 4WL4 | 2015-10-14 | 1.1 | Crystal structure of human carbonic anhydrase II in complex with the 6-hydroxy-chromene-2-thione inhibitor |
| 3SAX | 2012-04-11 | 1.1 | Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-{[(5-ethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide |
| 3D92 | 2008-09-02 | 1.1 | Human carbonic anhydrase II bound with substrate carbon dioxide |
| 5NXV | 2018-01-17 | 1.1 | Carbonic Anhydrase II Inhibitor RA8 |
| 5NY1 | 2018-01-17 | 1.1 | Carbonic Anhydrase II Inhibitor RA10 |
| 5NY6 | 2018-01-17 | 1.1 | Carbonic Anhydrase II Inhibitor RA12 |
| 4YGJ | 2015-03-25 | 1.1 | NaBr--Interactions between Hofmeister Anions and the Binding Pocket of a Protein |
| 5LLC | 2017-08-16 | 1.1 | Crystal structure of human carbonic anhydrase isozyme II with 3-(Methylamino)-2,5,6-trifluoro-4-[(2-phenylethyl)sulfonyl]benzenesulfonamide |
| 5DRS | 2016-09-28 | 1.1 | Crystal structure of human carbonic anhydraseisozyme II with 3-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide |
| 5JGS | 2017-01-11 | 1.11 | Human carbonic anhydrase II (F131Y/L198A) complexed with benzo[d]thiazole-2-sulfonamide |
| 5LLG | 2017-08-16 | 1.12 | Crystal structure of human carbonic anhydrase isozyme II with 4-Propylthiobenzenesulfonamide |
| 4Q6D | 2014-11-26 | 1.12 | Crystal structure of human carbonic anhydrase isozyme II with 4-[(Z)-azepan-1-yldiazenyl]benzenesulfonamide |
| 5LL4 | 2017-08-16 | 1.12 | Crystal structure of human carbonic anhydrase isozyme II with 4-(1H-benzimidazol-1-ylacetyl)benzenesulfonamide |
| 4Q6E | 2014-11-26 | 1.12 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[3-(3,5-Dimethyl-1H-pyrazol-1-yl)-3-oxopropyl]amino}benzene-1-sulfonamide |
| 6G6T | 2019-03-13 | 1.12 | Crystal structure of human carbonic anhydrase isozyme II with N-butyl-2,4-dichloro-5-sulfamoyl-benzamide |
| 5EKJ | 2016-01-06 | 1.13 | Human Carbonic Anhydrase II complexed with a two-faced guest |
| 5JEH | 2017-01-11 | 1.13 | Human carbonic anhydrase II (L198A) complexed with benzo[d]thiazole-2-sulfonamide |
| 4RUY | 2015-04-22 | 1.14 | Crystal structure of human Carbonic Anhydrase II in complex with 4-propoxybenzenesulfonamide |
| 4RUX | 2015-04-22 | 1.14 | Crystal structure of human Carbonic Anhydrase II in complex with 4-(allyloxy)benzenesulfonamide |
| 3MHO | 2010-10-20 | 1.15 | Crystal structure of human carbonic anhydrase isozyme II with 4-[N-(6-chloro-5-formyl-2-methylthiopyrimidin-4-yl)amino]benzenesulfonamide |
| 4Q06 | 2015-01-28 | 1.15 | Crystal structure of chimeric carbonic anhydrase IX with inhibitor |
| 5BYI | 2015-08-05 | 1.15 | Human carbonic anhydrase II with an azobenzene inhibitor (1d) |
| 5SZ6 | 2016-12-28 | 1.15 | Carbonic anhydrase IX-mimic in complex with 4-(3-formylphenyl)-benzenesulfonamide |
| 2FOV | 2006-04-04 | 1.15 | Human Carbonic Anhydrase II complexed with two-prong inhibitors |
| 2EU2 | 2006-07-11 | 1.15 | Human Carbonic Anhydrase II in complex with novel inhibitors |
| 4Q07 | 2015-01-28 | 1.15 | Crystal structure of chimeric carbonic anhydrase IX with inhibitor |
| 5JE7 | 2017-01-11 | 1.15 | Human carbonic anhydrase II (F131Y) complexed with benzo[d]thiazole-2-sulfonamide |
| 2NXT | 2007-04-24 | 1.15 | Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II |
| 6IC2 | 2019-05-15 | 1.15 | Polypharmacology of Epacadostat: a Potent and Selective Inhibitor of the Tumor Associated Carbonic Anhydrases IX and XII |
| 4HF3 | 2013-10-23 | 1.15 | Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure |
| 5NXI | 2018-01-17 | 1.16 | Carbonic Anhydrase II Inhibitor RA2 |
| 3RYY | 2011-08-10 | 1.16 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 4ITO | 2014-03-26 | 1.16 | Human CA II inhibition by novel sulfonamide |
| 3M2Y | 2011-05-25 | 1.17 | Carbonic Anhydrase II in complex with novel sulfonamide inhibitor |
| 5MJN | 2017-12-06 | 1.17 | Three dimensional structure of human carbonic anhydrase II in complex with 5-[(4Chlorobenzyl)sulfanyl]thiophene-2-sulfonamide |
| 5JEG | 2017-01-11 | 1.19 | Human carbonic anhydrase II (V121I) complexed with benzo[d]thiazole-2-sulfonamide |
| 5JEP | 2017-01-11 | 1.19 | Human carbonic anhydrase II (T199S) complexed with benzo[d]thiazole-2-sulfonamide |
| 5JG5 | 2017-01-11 | 1.19 | Human carbonic anhydrase II (V121T/F131Y) complexed with benzo[d]thiazole-2-sulfonamide |
| 2NNG | 2007-05-08 | 1.2 | Structure of inhibitor binding to Carbonic Anhydrase II |
| 3RYV | 2011-08-10 | 1.2 | Carbonic Anhydrase complexed with N-ethyl-4-sulfamoylbenzamide |
| 5YUI | 2018-08-01 | 1.2 | CO2 release in human carbonic anhydrase II crystals: reveal histidine 64 and solvent dynamics |
| 5NXG | 2018-01-17 | 1.2 | Carbonic Anhydrase II Inhibitor RA1 |
| 4Q09 | 2015-01-28 | 1.2 | Crystal structure of chimeric carbonic anhydrase XII with inhibitor |
| 5T74 | 2017-09-06 | 1.2 | Human carboanhydrase F131C_C206S double mutant in complex with 14 |
| 5NYA | 2018-01-17 | 1.2 | Carbonic Anhydrase II Inhibitor RA13 |
| 4FIK | 2012-06-27 | 1.2 | Human carbonic anhydrase II H64A complexed with thioxolone hydrolysis products |
| 6QFW | 2019-04-17 | 1.2 | Human carbonic anhydrase II with bound IrCp* complex (cofactor 9) to generate an artificial transfer hydrogenase (ATHase) |
| 3RJ7 | 2012-02-29 | 1.2 | Human carbonic anhydrase II complexed with its inhibitor rhenium(I)triscarbonyl-cyclopentadienyl-carboxy-4-aminomethylbenzene-sulfonamide |
| 6B4D | 2018-02-07 | 1.2 | Crystal structure of human carbonic anhydrase II in complex with a heteroaryl-pyrazole carboxylic acid derivative. |
| 5NXO | 2018-01-17 | 1.2 | Carbonic Anhydrase II Inhibitor RA6 |
| 5JES | 2017-01-11 | 1.21 | Human carbonic anhydrase II (V121T) complexed with benzo[d]thiazole-2-sulfonamide |
| 5U0F | 2017-08-30 | 1.21 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 5EH5 | 2016-03-09 | 1.21 | human carbonic anhydrase II in complex with ligand |
| 5JG3 | 2017-01-11 | 1.21 | Human carbonic anhydrase II (121T/N67Q) complexed with benzo[d]thiazole-2-sulfonamide |
| 5TXY | 2017-08-30 | 1.21 | Identification of a New Zinc Binding Chemotype of by Fragment Screening on human carbonic anhydrase |
| 5EHV | 2016-03-09 | 1.21 | human carbonic anhydrase II in complex with ligand |
| 6D1M | 2018-06-13 | 1.21 | Design, synthesis, and X-ray of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects |
| 3L14 | 2011-01-05 | 1.22 | Human Carbonic Anhydrase II complexed with Althiazide |
| 4CNX | 2015-02-04 | 1.23 | Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture |
| 4YGN | 2015-03-25 | 1.23 | NaI--Interactions between Hofmeister Anions and the Binding Pocket of a Protein |
| 2FOQ | 2006-02-28 | 1.25 | Human Carbonic Anhydrase II complexed with two-prong inhibitors |
| 3S71 | 2011-10-19 | 1.25 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 5YUJ | 2018-08-01 | 1.25 | CO2 release in human carbonic anhydrase II crystals: reveal histidine 64 and solvent dynamics |
| 5NXP | 2018-01-17 | 1.25 | Carbonic Anhydrase II Inhibitor RA7 |
| 5NXM | 2018-05-30 | 1.25 | Carbonic Anhydrase II Inhibitor RA1 |
| 5WEX | 2017-10-11 | 1.26 | Discovery of new selenoureido analogs of 4-(4-fluorophenylureido) benzenesulfonamides as carbonic anhydrase inhibitors |
| 3GZ0 | 2009-07-21 | 1.26 | Apo-human carbonic anhydrase II revisited: Implications of the loss of a metal in protein structure, stability and solvent network |
| 5U0E | 2017-08-30 | 1.27 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 5SZ5 | 2016-12-28 | 1.27 | Carbonic anhydrase IX-mimic in complex with 4-(2-methylphenyl)-benzenesulfonamide |
| 4Z1J | 2015-08-26 | 1.27 | Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV) |
| 6C7W | 2018-05-23 | 1.28 | Carbonic anhydrase 2 in complex with [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDRO-2-FURANYL]METHYL SULFAMATE inhibitor |
| 5G0C | 2016-05-25 | 1.28 | An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C |
| 5NEA | 2017-12-06 | 1.3 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(2-methyl-1,3-oxazol-5-yl)benzene-1-sulfonammide |
| 6ODZ | 2019-06-12 | 1.3 | Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects |
| 5T71 | 2017-09-06 | 1.3 | Human carboanhydrase F131C_C206S double mutant in complex with SA-2 |
| 5N1R | 2017-12-27 | 1.3 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4'-Pyrazol-1-ylmethyl-biphenyl-4-sulfonamide |
| 5DSK | 2016-05-04 | 1.3 | Structure of CO2 released holo-form of human carbonic anhydrase II with 3 min warming |
| 6GXE | 2019-05-08 | 1.3 | Carbonic Anhydrase CAIX mimic in complex with inhibitor JS14 |
| 6OE0 | 2019-06-12 | 1.3 | Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects |
| 4QIY | 2015-04-15 | 1.3 | Crystal structure of human carbonic anhydrase isozyme II with inhibitor |
| 5DSR | 2016-05-04 | 1.3 | Structure of CO2 released apo-form of human carbonic anhydrase II with 10 min warming |
| 3PYK | 2011-07-13 | 1.3 | Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor |
| 5T72 | 2017-09-06 | 1.3 | Human carboanhydrase F131C_C206S double mutant in complex with 2 |
| 5N1S | 2017-12-27 | 1.3 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(1H-Indol-2-yl)-benzenesulfonamide |
| 3S8X | 2012-04-11 | 1.3 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[(4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide |
| 5DSM | 2016-05-04 | 1.3 | Structure of CO2 released holo-form of human carbonic anhydrase II with 25 min warming |
| 3S9T | 2012-04-18 | 1.3 | Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-{[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide |
| 5E28 | 2016-01-20 | 1.3 | Crystal structure of human carbonic anhydrase II in complex with the 4-(4-aminophenyl)benzenesulfonamide inhibitor |
| 4RH2 | 2015-11-11 | 1.3 | Crystal structure of human carbonic anhydrase II in complex with 2-(6-hydroxy-3-Oxo-3H-xanthen-9-yl)-5-{3-1-(4-sulfamoyl-phenyl)-1h-[1,2,3]triazol-4-ylmethyl-thioureido}-benzoic acid |
| 6H3Q | 2019-07-17 | 1.31 | Crystal structure of human carbonic anhydrase II in complex with the 4-(5-(chloromethyl)-1,3-selenazol-2-yl)benzenesulfonamide |
| 3ZP9 | 2013-10-30 | 1.31 | Human Carbonic Anhydrase II as a Scaffold for an Artificial Transfer Hydrogenase |
| 6QFX | 2019-04-17 | 1.32 | Human carbonic anhydrase II with bound IrCp* complex (cofactor 10) to generate an artificial transfer hydrogenase (ATHase) |
| 5ZXW | 2018-06-13 | 1.32 | Crystal structure of human carbonic anhydrase II crystallized by ammonium sulfate |
| 5THN | 2017-04-26 | 1.33 | Crystal Structure of 2-Hydroxycyclohepta-2,4,6-triene-1-thione bound to human carbonic anhydrase 2 |
| 5EKM | 2016-01-06 | 1.33 | Human Carbonic Anhydrase II complexed with a two-faced guest |
| 4HEZ | 2013-10-23 | 1.34 | Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure |
| 5JDV | 2017-01-11 | 1.34 | Human carbonic anhydrase II (F131W) complexed with benzo[d]thiazole-2-sulfonamide |
| 5EKH | 2016-01-06 | 1.34 | Human Carbonic Anhydrase II complexed with a two-faced guest |
| 4Z1K | 2015-08-26 | 1.35 | Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV) |
| 6GXB | 2019-05-08 | 1.35 | Carbonic Anhydrase CAIX mimic in complex with inhibitor JS13 |
| 4QK3 | 2015-03-04 | 1.35 | Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - [delta]230-240 |
| 3M1K | 2010-11-17 | 1.35 | Carbonic Anhydrase in complex with fragment |
| 5G03 | 2016-05-25 | 1.35 | An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C |
| 3MYQ | 2011-02-02 | 1.35 | Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-[(1H-imidazo[4,5-c]quinolin-2-ylsulfanyl)acetyl]benzenesulfonamide |
| 4BF1 | 2014-01-22 | 1.35 | Three dimensional structure of human carbonic anhydrase II in complex with 5-(1-naphthalen-1-yl-1,2,3-triazol-4-yl)thiophene-2-sulfonamide |
| 5ULN | 2017-10-11 | 1.35 | Synthesis of novel seleno ureido containing compounds as SLC-0111 analogs. Investigations on carbonic anhydrases activity, glutathione peroxidase and X-ray crystallography |
| 4KUV | 2014-06-25 | 1.35 | Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(4-chlorophenylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor |
| 3KNE | 2011-05-18 | 1.35 | Carbonic Anhydrase II H64C mutant in complex with an in situ formed triazole |
| 4MDG | 2014-01-01 | 1.35 | Closo Carborane Carbonic Anhydrase Inhibitor |
| 5JQT | 2016-10-19 | 1.36 | Crystal structure of human carbonic anhydrase II in complex with Benzoxaborole at pH 7.4 |
| 5AML | 2015-04-08 | 1.36 | Three dimensional structure of human carbonic anhydrase II in complex with 2-(But-2-yn-1-ylsulfamoyl)-4-sulfamoylbenzoic acid |
| 6PGX | 2019-08-21 | 1.36 | Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity |
| 3RYZ | 2011-08-10 | 1.37 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 5EH8 | 2016-03-09 | 1.38 | human carbonic anhydrase II in complex with ligand |
| 3M14 | 2011-05-25 | 1.38 | Carbonic Anhydrase II in complex with novel sulfonamide inhibitor |
| 3M1W | 2011-05-25 | 1.38 | Carbonic Anhyrdase II mutant W5CH64C with closed disulfide bond in complex with sulfate |
| 3KIG | 2010-11-17 | 1.39 | Mutant carbonic anhydrase II in complex with an azide and an alkyne |
| 3RYJ | 2011-08-10 | 1.39 | Carbonic Anhydrase complexed with 4-sulfamoyl-N-(2,2,2-trifluoroethyl)benzamide |
| 5VGY | 2017-08-30 | 1.39 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 5EHW | 2016-03-09 | 1.39 | human carbonic anhydrase II in complex with ligand |
| 5WLU | 2018-08-01 | 1.39 | Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide |
| 5DSP | 2016-05-04 | 1.4 | Structure of CO2 released apo-form of human carbonic anhydrase II with 40 sec warming |
| 5WLV | 2018-08-01 | 1.4 | Carbonic Anhydrase II in complex with aryloxy-2-hydroxypropylammine sulfonamide |
| 5BRW | 2015-06-17 | 1.4 | Catalytic Improvement of an Artificial Metalloenzyme by Computational Design |
| 3M96 | 2011-02-02 | 1.4 | Crystal structure of human carbonic anhydrase isozyme II with 5-{[(5-bromo-1H-benzimidazol-2-yl)sulfanyl]acetyl}-2-chlorobenzenesulfonamide |
| 5JQ0 | 2016-10-19 | 1.4 | Crystal structure of human carbonic anhydrase II in complex with Benzoxaborole at pH=8.7 |
| 5N25 | 2017-12-27 | 1.4 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-Pyridin-3-yl-benzenesulfonamide |
| 2WEO | 2009-11-10 | 1.4 | Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors |
| 3M04 | 2011-05-25 | 1.4 | Carbonic Anhydrase II in complex with novel sulfonamide inhibitor |
| 4QSB | 2015-01-21 | 1.4 | Crystal structure of human carbonic anhydrase isozyme II with 3-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}benzenesulfonamide |
| 5NY3 | 2018-01-17 | 1.4 | Carbonic Anhydrase II Inhibitor RA11 |
| 6D1L | 2018-06-13 | 1.4 | Design, synthesis, and X-ray of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects |
| 5DSO | 2016-05-04 | 1.4 | Structure of CO2 bound apo-form of human carbonic anhydrase II with 0 sec (no) warming |
| 3MWO | 2010-06-09 | 1.4 | Human carbonic anhydrase II in a doubled monoclinic cell: a re-determination |
| 5G01 | 2016-05-25 | 1.4 | An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C |
| 2QO8 | 2008-01-22 | 1.4 | Crystal structure of the complex of hcaii with an indane-sulfonamide inhibitor |
| 5E2K | 2016-01-20 | 1.4 | Crystal structure of human carbonic anhydrase II in complex with the 4-(3-aminophenyl)benzenesulfonamide inhibitor |
| 3SBI | 2012-04-11 | 1.4 | Crystal structure of human carbonic anhydrase isozyme II with 4-[(2-pyrimidinylsulfanyl)acetyl]benzenesulfonamide |
| 3S74 | 2011-10-19 | 1.4 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 3M5S | 2011-05-25 | 1.4 | Carbonic Anhydrase II mutant H64C in complex with carbonate |
| 3IBU | 2009-09-22 | 1.41 | The crystal structure of the human carbonic anhydrase II in complex with an aliphatic sulfamate inhibitor |
| 5TI0 | 2017-04-26 | 1.42 | Crystal Structure of 2-Hydroxycyclohepta-2,4,6-triene-1-thione bound to human carbonic anhydrase 2 L198G |
| 5EH7 | 2016-03-09 | 1.42 | human carbonic anhydrase II in complex with ligand |
| 5LVS | 2017-03-08 | 1.42 | Self-assembled protein-aromatic foldamer complexes with 2:3 and 2:2:1 stoichiometries |
| 6CEH | 2018-05-23 | 1.43 | Design, Synthesis, X-ray and Biological Activities of Selenides Bearing the Benzenesulfonamide Moiety as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology |
| 3HLJ | 2010-03-02 | 1.44 | Crystal structure of human carbonic anhydrase isozyme II with 3-methylthiobenzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonamide |
| 6HX5 | 2018-12-26 | 1.44 | Selenols: a new class of Carbonic Anhydrase inhibitors |
| 4Q8Y | 2015-03-11 | 1.45 | Crystal structure of 2-hydroxyisoquinoline-1(2H)-thione bound to human carbonic anhydrase II |
| 5WG7 | 2018-02-07 | 1.45 | Human Carbonic Anhydrase II complexed with AceK |
| 5YUK | 2018-08-01 | 1.45 | CO2 release in human carbonic anhydrase II crystals: reveal histidine 64 and solvent dynamics |
| 5TY8 | 2017-08-30 | 1.45 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 2QP6 | 2008-06-03 | 1.45 | The crystal structure of the complex of hcaII with a bioreductive antitumor derivative |
| 4YWP | 2015-10-14 | 1.45 | Sucrose Binding Site in genetically engineered Carbonic anhydrase IX |
| 3OKV | 2011-07-06 | 1.45 | Human Carbonic Anhydrase II A65S, N67Q (CA IX mimic) bound with 2-Ethylestrone 3-O-sulfamate |
| 6H6S | 2019-01-09 | 1.45 | Sad phasing on nickel-substituted human carbonic anhydrase II |
| 6QFV | 2019-04-17 | 1.45 | Human carbonic anhydrase II with bound IrCp* complex (cofactor 8) to generate an artificial transfer hydrogenase (ATHase) |
| 4E49 | 2012-06-27 | 1.45 | Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors |
| 4KAP | 2013-07-10 | 1.45 | The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand |
| 4E4A | 2012-06-27 | 1.45 | Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors |
| 4Z0Q | 2015-08-26 | 1.45 | Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV) |
| 3OIM | 2011-07-06 | 1.45 | Human Carbonic anhydrase II bound by 2-Ethylestradiol 3-O-sulfamate |
| 5DSL | 2016-05-04 | 1.45 | Structure of CO2 released holo-form of human carbonic anhydrase II with 10 min warming |
| 4YVY | 2016-03-30 | 1.45 | Crystal structure of human carbonic anhydrase II in complex with hydroxylamine-O-sulfonamide, a molecule incorporating two zinc-binding groups. |
| 4Q7W | 2015-03-11 | 1.45 | Crystal structure of 1-hydroxy-6-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 2WEJ | 2009-11-10 | 1.45 | Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors |
| 6OE1 | 2019-06-12 | 1.45 | Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects |
| 3OKU | 2011-07-06 | 1.45 | Human Carbonic Anhydrase II in complex with 2-Ethylestrone-3-O-sulfamate |
| 4HEY | 2013-10-23 | 1.45 | Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure |
| 4CQ0 | 2014-04-16 | 1.45 | Cyclic secondary sulfonamides: unusually good inhibitors of cancer- related carbonic anhydrase enzymes |
| 6H29 | 2018-09-05 | 1.46 | HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BENZYL CARBAMATE |
| 2GD8 | 2007-02-06 | 1.46 | Crystal structure analysis of the human carbonic anhydrase II in complex with a 2-substituted estradiol bis-sulfamate |
| 2AW1 | 2006-07-04 | 1.46 | Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor Celecoxib |
| 4Z1N | 2015-08-26 | 1.47 | Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV) |
| 3QYK | 2012-03-07 | 1.47 | Human Carbonic Anhydrase II complexed with triple ring benzene sulfonamide inhibitor |
| 3V2M | 2012-12-26 | 1.47 | Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II |
| 3OYQ | 2011-08-10 | 1.47 | Structure of Human Carbonic Anhydrase II complexed with 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE |
| 4QEF | 2014-10-08 | 1.47 | Human Carbonic Anhydrase II V207I - cyanate inhibitor complex |
| 5TH4 | 2017-04-26 | 1.47 | Crystal Structure of 1-hydroxypyridine-2(1H)-thione bound to human carbonic anhydrase 2 L198G |
| 3PO6 | 2011-04-06 | 1.47 | Crystal structure of human carbonic anhydrase II with 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide |
| 3DD0 | 2009-03-03 | 1.48 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 4DZ7 | 2013-03-27 | 1.49 | hCA II in complex with novel sulfonamide inhibitors Set D |
| 3P5A | 2011-10-19 | 1.49 | Human Carbonic Anhydrase complexed with Sodium morpholinocarbodithioate |
| 2WD2 | 2010-03-31 | 1.49 | A chimeric microtubule disruptor with efficacy on a taxane resistant cell line |
| 5WLR | 2018-08-01 | 1.49 | Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide |
| 4DZ9 | 2013-03-27 | 1.49 | hCA II in complex with novel sulfonamide inhibitors Set D |
| 3P58 | 2011-10-19 | 1.49 | Human Carbonic Anhydrase in complex with Benzyl (Methyl) Carbamodithoic Acid |
| 3OIL | 2011-07-06 | 1.5 | Human Carbonic anhydrase II mutant A65S, N67Q (CA IX mimic) bound by 2-Ethylestradiol 3-O-sulfamate |
| 5AMD | 2015-04-08 | 1.5 | Three dimensional structure of human carbonic anhydrase II in complex with 2-((2-Phenylethyl)sulfamoyl)-4-sulfamoylbenzoic acid |
| 3KON | 2010-08-25 | 1.5 | Crystal structure of cobalt (II) human carbonic anhydrase II at pH 11.0 |
| 4E3H | 2012-06-27 | 1.5 | Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors |
| 5EHE | 2016-11-09 | 1.5 | Crystal structure of human carbonic anhydrase isozyme II with 3-(benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide |
| 3OIK | 2011-07-06 | 1.5 | Human Carbonic anhydrase II mutant A65S, N67Q (CA IX mimic) bound by 2-Ethylestradiol 3,17-O,O-bis-sulfamate |
| 5TFX | 2017-08-09 | 1.5 | New method for synthesis of benzoxazole amide inhibitors of carbonic anhydrase |
| 5THI | 2017-04-26 | 1.5 | Crystal Structure of 2-hydroxycyclohepta-2,4,6-trien-1-one bound to human carbonic anhydrase 2 L198G |
| 6C7X | 2018-05-23 | 1.5 | Carbonic anhydrase 2 in complex with 2-chloro-5'-O-sulfamoyladenosine |
| 4GL1 | 2013-09-04 | 1.5 | Structure of H64A/N62L/N67L Human Carbonic Anhydrase II triple mutant |
| 3P3H | 2011-09-21 | 1.5 | Human carbonic anhydrase II in complex with p-(5-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide |
| 3KOK | 2010-08-25 | 1.5 | Crystal structure of cobalt (II) human carbonic anhydrase II at pH 8.5 |
| 3MMF | 2011-04-20 | 1.5 | Crystal structure of human carbonic anhydrase II in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor |
| 3RLD | 2012-02-08 | 1.5 | Crystal structure of the Y7I mutant of human carbonic anhydrase II |
| 5E2S | 2016-01-20 | 1.5 | Crystal structure of human carbonic anhydrase II in complex with the 4-(2-iso-propylphenyl)benzenesulfonamide inhibitor |
| 3N3J | 2011-03-09 | 1.5 | Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor |
| 3P5L | 2011-10-19 | 1.5 | Human Carbonic Anhydrase complexed with sodium 4-cyano-4-phenylpiperidine-1-carbodithioate |
| 5N24 | 2017-12-27 | 1.5 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor b4'-Cyano-biphenyl-4-sulfonic acid amide |
| 4R5B | 2014-10-15 | 1.5 | Human Carbonic Anhydrase II in Complex with a Carbohydrate-Based Sulfamate |
| 3DCW | 2009-03-03 | 1.5 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 4ZWY | 2015-08-05 | 1.5 | Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor |
| 2AX2 | 2006-01-03 | 1.5 | Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II |
| 3S75 | 2011-10-19 | 1.5 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 4Q99 | 2015-03-11 | 1.5 | Crystal structure of 2-mercapto-4-methylphenol bound to human carbonic anhydrase II |
| 4JSA | 2013-06-19 | 1.5 | Benzenesulfonamide complexed with hCAII H94D |
| 1FR7 | 2001-01-17 | 1.5 | X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT |
| 4QSA | 2015-01-21 | 1.5 | Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-4-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}benzenesulfonamide |
| 3N0N | 2011-03-16 | 1.5 | Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor |
| 4ZX1 | 2015-10-28 | 1.5 | Engineered Carbonic Anhydrase IX mimic in complex with a glucosyl sulfamate inhibitor |
| 5TYA | 2017-08-30 | 1.5 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 3M98 | 2011-03-02 | 1.5 | Crystal structure of human carbonic anhydrase isozyme II with 5-(1H-benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide |
| 4E3F | 2012-06-27 | 1.5 | Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors |
| 4Q8Z | 2015-03-11 | 1.5 | Crystal structure of 1-hydroxy-4-methylpyridin-2(1H)-one bound to human carbonic anhydrase II |
| 5THJ | 2017-04-26 | 1.5 | Crystal Structure of 2-hydroxycyclohepta-2,4,6-trien-1-one bound to human carbonic anhydrase 2 |
| 4BCW | 2013-02-06 | 1.5 | Carbonic anhydrase IX mimic in complex with (E)-2-(5-bromo-2- hydroxyphenyl)ethenesulfonic acid |
| 5DSQ | 2016-05-04 | 1.5 | Structure of CO2 released apo-form of human carbonic anhydrase II with 3 min warming |
| 5T75 | 2017-09-06 | 1.5 | Human carbonic anhydrase II G132C_C206S double mutant in complex with SA-2 |
| 4JSS | 2013-06-19 | 1.5 | Human carbonic anhydrase II H94D bound to a bidentate inhibitor |
| 3TVN | 2012-08-08 | 1.5 | Human Carbonic Anhydrase II Proton Transfer Mutant |
| 3MHM | 2010-10-20 | 1.5 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-benzylamino-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide |
| 4YGK | 2015-03-25 | 1.5 | NaSCN--Interactions between Hofmeister Anions and the Binding Pocket of a Protein |
| 4QY3 | 2014-12-03 | 1.5 | THE CRYSTAL STRUCTURE OF THE COMPLEX of HCAII WITH AN ORTHO-SUBSTITUTED BENZOIC ACID |
| 3MZC | 2011-03-09 | 1.5 | Human carbonic ahydrase II in complex with a benzenesulfonamide inhibitor |
| 3V5G | 2012-07-25 | 1.5 | Crystal structure of human carbonic anhydrase II in complex with the 4-sulfamido-benzenesulfonamide inhibitor |
| 6MBY | 2019-03-13 | 1.5 | Carbonic Anhydrase II in complex with Ferulic Acid |
| 3RG4 | 2012-02-22 | 1.5 | Crystal structure of the W5F mutant of human carbonic anhydrase II |
| 3MNA | 2011-04-20 | 1.5 | The crystal structure of human carbonic anhydrase Ii in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor |
| 1OQ5 | 2004-03-23 | 1.5 | CARBONIC ANHYDRASE II IN COMPLEX WITH NANOMOLAR INHIBITOR |
| 3RZ1 | 2011-08-10 | 1.51 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 4YGL | 2015-03-25 | 1.51 | NaClO4--Interactions between Hofmeister Anions and the Binding Pocket of a Protein |
| 4QK2 | 2015-03-04 | 1.52 | Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - E234P |
| 5JN1 | 2017-05-03 | 1.52 | Carbonic Anhydrase IX-mimic IN Complex WITH U-CH3 |
| 4MDL | 2014-01-01 | 1.52 | Meta Carborane Carbonic Anhydrase Inhibitor |
| 5JN7 | 2017-05-03 | 1.52 | Carbonic Anhydrase II In Complex WITH U-CH3 |
| 5WGP | 2018-02-07 | 1.53 | Human Carbonic Anhydrase IX-mimic complexed with AceK |
| 4RN4 | 2015-01-28 | 1.53 | Human Carbonic anhydrases II in complex with a acetazolamide derivative comprising one hydrophobic and one hydrophilic tail moiety |
| 5TY9 | 2017-08-30 | 1.53 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 2CBA | 1993-10-31 | 1.54 | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES |
| 4N16 | 2014-06-18 | 1.54 | Structure of cholate bound to human carbonic anhydrase II |
| 3OYS | 2011-08-10 | 1.54 | Human Carbonic Anhydrase II complexed with 2-{[4-AMINO-3-(3-HYDROXYPROP-1-YN-1-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL]METHYL}-5-METHYL-3-(2-METHYLPHENYL)QUINAZOLIN-4(3H)-ONE |
| 4Q90 | 2015-03-11 | 1.54 | Crystal structure of 4-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 5U0G | 2017-08-30 | 1.54 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 5EZT | 2016-07-20 | 1.54 | Peracetylated Bovine Carbonic Anhydrase II |
| 4MDM | 2014-01-01 | 1.55 | Nido-Carborane Carbonic Anhydrase Inhibitor |
| 3U3A | 2012-10-10 | 1.55 | structure of Human Carbonic Anhydrase II V143I |
| 5SZ1 | 2016-12-21 | 1.55 | Carbonic anhydrase II in complex with 4-(2-methylphenyl)-benzenesulfonamide |
| 4Q83 | 2015-03-11 | 1.55 | Crystal structure of 1-hydroxy-3-(trifluoromethyl)pyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 4E3G | 2012-06-27 | 1.55 | Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors |
| 4Q9Y | 2015-03-11 | 1.55 | Crystal structure of 3-methylthiophenol bound to human carbonic anhydrase II |
| 4KV0 | 2014-06-25 | 1.55 | Crystal structure of human carbonic anhydrase II in complex with the 5-(3-tosylureido)pyridine-2-sulfonamide inhibitor |
| 2HNC | 2006-12-19 | 1.55 | Crystal structure of the human carbonic anhydrase II in complex with the 5-amino-1,3,4-thiadiazole-2-sulfonamide inhibitor. |
| 2HL4 | 2007-05-22 | 1.55 | Crystal structure analysis of human carbonic anhydrase II in complex with a benzenesulfonamide derivative |
| 6H34 | 2018-12-19 | 1.55 | The crystal structure of human carbonic anhydrase II in complex with 4-[(4-fluorophenyl)methyl]-1-piperazinyl]benzenesulfonamide. |
| 4Q87 | 2015-03-11 | 1.55 | Crystal structure of 1-hydroxy-4-(trifluoromethyl)pyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 5G0B | 2016-05-25 | 1.55 | An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C |
| 4Q81 | 2015-03-11 | 1.55 | Crystal structure of 1-hydroxy-4,6-dimethylpyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 4Q8X | 2015-03-11 | 1.55 | Crystal structure of 1-hydroxy-5-(trifluoromethyl)pyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 3IBL | 2009-09-22 | 1.55 | The crystal structure of the human carbonic anhydrase II in complex with an aliphatic bis-sulfamate inhibitor |
| 4JS6 | 2013-06-19 | 1.55 | Crystal structure of inhibitor-free hCAII H94D |
| 1ZFQ | 2006-05-23 | 1.55 | carbonic anhydrase II in complex with ethoxzolamidphenole as sulfonamide inhibitor |
| 4KUW | 2014-06-25 | 1.55 | Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(4-fluorophenylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor |
| 5CLU | 2015-11-11 | 1.55 | THE CRYSTAL STRUCTURE OF THE COMPLEX of HCAII WITH A SACCHARINE DERIVATIVE |
| 6CJV | 2018-08-08 | 1.55 | Carbonic anhydrase IX-mimic in complex with sucralose |
| 5AMG | 2015-04-08 | 1.55 | Three dimensional structure of human carbonic anhydrase II in complex with 2-(Pentylsulfamoyl)-4-sulfamoylbenzoic acid |
| 3V3G | 2012-06-20 | 1.56 | Kinetic and structural studies of thermostabilized mutants of HCA II. |
| 2VVA | 2009-07-14 | 1.56 | Human carbonic anhydrase in complex with CO2 |
| 6GOT | 2018-10-03 | 1.56 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(phenethylthio)benzenesulfonamide |
| 1ZFK | 2006-05-23 | 1.56 | carbonic anhydrase II in complex with N-4-sulfonamidphenyl-N'-4-methylbenzosulfonylurease as sulfonamide inhibitor |
| 5WLT | 2018-08-01 | 1.57 | Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide |
| 5A6H | 2016-05-25 | 1.57 | Synthesis, carbonic anhydrase inhibition and protein X-ray structure of the unusual natural product primary sulfonamide Psammaplin C |
| 6H33 | 2018-12-19 | 1.58 | The crystal structure of human carbonic anhydrase II in complex with 4-(4-phenyl)-4-hydroxy-1-piperidine-1-carbonyl)benzenesulfonamide. |
| 5FNL | 2016-09-28 | 1.59 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 5FNM | 2016-03-02 | 1.59 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 5FNK | 2016-03-02 | 1.59 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 5U0D | 2017-08-30 | 1.59 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 4ILX | 2013-02-13 | 1.6 | Structure of human carbonic anhydrase II in complex with an adamantyl sulfonamide inhibitor |
| 5BRU | 2015-06-24 | 1.6 | Catalytic Improvement of an Artificial Metalloenzyme by Computational Design |
| 2OSM | 2008-02-12 | 1.6 | Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study |
| 3R16 | 2011-05-25 | 1.6 | Human CAII bound to N-(4-sulfamoylphenyl)-2-(thiophen-2-yl) acetamide |
| 3DVC | 2008-11-11 | 1.6 | X-ray crystal structure of mutant N62T of human Carbonic Anhydrase II |
| 4K13 | 2014-04-09 | 1.6 | Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with dorzolamide |
| 3DAZ | 2009-03-03 | 1.6 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 1G0E | 2000-10-18 | 1.6 | SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH 4-METHYLIMIDAZOLE |
| 3TVO | 2012-08-08 | 1.6 | Human Carbonic Anhydrase II Proton Transfer Double Mutant |
| 3P3J | 2011-09-21 | 1.6 | Human carbonic anhydrase II in complex with p-(5-ruthenocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide |
| 3DCC | 2009-03-03 | 1.6 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 3DVD | 2008-11-11 | 1.6 | X-ray crystal structure of mutant N62D of human Carbonic Anhydrase II |
| 3RYX | 2011-08-10 | 1.6 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 5W8B | 2018-05-30 | 1.6 | Carbonic anhydrase II in complex with activating histamine pyridinium derivative |
| 4IWZ | 2013-12-11 | 1.6 | structure of hCAII in complex with an acetazolamide derivative |
| 4Q7V | 2015-03-11 | 1.6 | Crystal structure of 1-hydroxy-5-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 5BRV | 2015-06-24 | 1.6 | Catalytic Improvement of an Artificial Metalloenzyme by Computational Design |
| 1G0F | 2000-10-18 | 1.6 | SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMAN CARBONIC ANHYDRASE II |
| 4E3D | 2012-06-27 | 1.6 | Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors |
| 4ZX0 | 2015-10-28 | 1.6 | Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor |
| 2FMG | 2006-05-23 | 1.6 | Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine and crystallographic analysis of their adducts with isozyme II: sterospecific recognition within the active site of an enzyme and its consequences for the drug design, structure with L-phenylalanine |
| 4IDR | 2012-12-26 | 1.6 | Human Carbonic Anhydrase II Proton Transfer Double Mutant |
| 2OSF | 2008-05-27 | 1.6 | Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study |
| 2QOA | 2008-01-22 | 1.6 | Crystal structure of the complex of hcaii with an indane-sulfonamide inhibitor |
| 5JN3 | 2017-05-03 | 1.6 | Carbonic Anhydrase IX-mimic IN Complex WITH U-F |
| 3M40 | 2010-10-20 | 1.6 | Crystal structure of human carbonic anhydrase isozyme II with 4-[N-(6-chloro-5-nitropyrimidin-4-yl)amino]benzenesulfonamide |
| 3DC9 | 2009-03-03 | 1.6 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 4QK1 | 2015-03-04 | 1.6 | Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - K170P |
| 1FR4 | 2001-01-17 | 1.6 | X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT |
| 1CIL | 1994-01-31 | 1.6 | THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS |
| 4HT0 | 2013-04-10 | 1.6 | Crystal structure of human carbonic anhydrase isozyme II with the inhibitor. |
| 2EU3 | 2006-07-11 | 1.6 | Human Carbonic anhydrase II in complex with novel inhibitors |
| 3S72 | 2011-10-19 | 1.6 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 3N4B | 2011-03-09 | 1.6 | Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor |
| 5FNI | 2016-03-02 | 1.6 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 3S76 | 2011-10-19 | 1.6 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 2POV | 2007-07-24 | 1.6 | The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-chloro-benzene-1,3-disulfonamide |
| 2FMZ | 2006-05-23 | 1.6 | Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine, structure with D-Phenylalanine. |
| 5TY1 | 2017-10-04 | 1.6 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 6E8X | 2019-03-27 | 1.6 | CA IX mimic Complexed with Steroidal Sulfamate Compound STX 140 |
| 2POU | 2007-07-24 | 1.6 | The crystal structure of the human carbonic anhydrase II in complex with 4,5-dichloro-benzene-1,3-disulfonamide |
| 5SZ4 | 2016-12-21 | 1.6 | Carbonic anhydrase IX-mimic in complex with 4-(phenyl)-benzenesulfonamide |
| 3U47 | 2012-10-10 | 1.6 | Human Carbonic Anhydrase II V143L |
| 5E2R | 2015-11-04 | 1.6 | The crystal structure of the human carbonic anhydrase II in complex with a 1,1'-biphenyl-4-sulfonamide inhibitor |
| 4ZWI | 2015-08-26 | 1.6 | Surface Lysine Acetylated Human Carbonic Anhydrase II in Complex with a Sulfamate-Based Inhibitor |
| 3OY0 | 2011-08-10 | 1.6 | Human Carbonic Anhydrase II complexed with 1-(4-(4-(2-(ISOPROPYLSULFONYL)PHENYLAMINO)-1H-PYRROLO[2,3-B]PYRIDIN-6-YLAMINO)-3-METHOXYPHENYL)PIPERIDIN-4-OL |
| 4LHI | 2014-07-02 | 1.6 | Crystal structure of human carbonic anhydrase isozyme II with 5-(phenylsulfonyl)thiophene-2-sulfonamide |
| 4ZWZ | 2015-08-05 | 1.62 | Engineered Carbonic Anhydrase IX mimic in complex with a glucosyl sulfamate inhibitor |
| 6B5A | 2018-09-05 | 1.62 | Carbonic anhydrase IX-mimic in complex with nitrogenous base-bearing benezenesulfonamide |
| 4CNV | 2015-02-04 | 1.62 | Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture |
| 5SZ2 | 2016-12-21 | 1.63 | Carbonic anhydrase II in complex with 4-(3-formylphenyl)-benzenesulfonamide |
| 3V3J | 2012-06-20 | 1.63 | Kinetic and structural studies of thermostabilized mutants of HCA II. |
| 6EEA | 2018-11-28 | 1.63 | Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. |
| 4L5V | 2014-04-30 | 1.63 | The structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II |
| 6EEH | 2018-11-28 | 1.63 | Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. |
| 1TH9 | 2005-01-25 | 1.63 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 5SZ0 | 2016-12-21 | 1.63 | Carbonic anhydrase II in complex with 4-(phenyl)-benzenesulfonamide |
| 4RIV | 2015-02-04 | 1.63 | A Carbonic Anhydrase IX Mimic in Complex with Saccharin |
| 4RUZ | 2015-04-22 | 1.63 | Crystal structure of human Carbonic Anhydrase II in complex with 4-ethoxybenzenesulfonamide |
| 4RFD | 2015-04-15 | 1.63 | Human carbonic anhydrase II in complex with 4-(4-sulfamoyl-phenoxy)-butylammonium |
| 4N0X | 2014-01-29 | 1.63 | Room temperature crystal structure of human carbonic anhydrase II in complex with thiophene-2-sulfonamide |
| 4R5A | 2014-10-15 | 1.64 | A Carbonic Anhydrase IX Mimic in Complex with a Carbohydrate-Based Sulfamate |
| 2X7S | 2010-03-31 | 1.64 | Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors. |
| 4RFC | 2015-04-15 | 1.64 | Human carbonic anhydrase II in complex with tert-butyl 4-(4-sulfamoylphenoxy)butylcarbamate |
| 3KOI | 2010-08-25 | 1.64 | Crystal structure of cobalt (III) human carbonic anhydrase II at pH 6.0 |
| 6B59 | 2018-09-05 | 1.64 | Carbonic anhydrase II in complex with nitrogenous base-bearing benezenesulfonamide |
| 4KUY | 2014-06-25 | 1.65 | Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(o-tolylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor |
| 2NWY | 2007-04-24 | 1.65 | Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II |
| 3D9Z | 2009-03-03 | 1.65 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 6EQU | 2017-12-13 | 1.65 | X-Ray crystal structure of the human carbonic anhydrase II adduct with a membrane-impermeant inhibitor |
| 4Q7P | 2015-03-11 | 1.65 | Crystal Structure of 1-hydroxy-3-methylpyridine-2(1H)-thione bound to hCAII |
| 3M2N | 2011-02-16 | 1.65 | Crystal structure of human carbonic anhydrase isozyme II with 4-{2-[N-(6-chloro-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide |
| 4R59 | 2014-10-15 | 1.65 | A Carbonic Anhydrase IX Mimic in Complex with a Carbohydrate-Based Sulfamate |
| 3T5Z | 2012-06-20 | 1.65 | Crystal structure of the human carbonic anhydrase II in complex with N-methoxy-benzenesulfonamide |
| 3N2P | 2011-03-09 | 1.65 | Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor |
| 3IGP | 2010-03-09 | 1.65 | Structure of inhibitor binding to Carbonic Anhydrase II |
| 3SBH | 2012-04-11 | 1.65 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide |
| 4RIU | 2015-02-04 | 1.65 | A Carbonic Anhydrase IX Mimic in Complex with a Saccharin-Based Inhibitor |
| 1ZGE | 2006-05-23 | 1.65 | carbonic anhydrase II in complex with p-Sulfonamido-o,o'-dichloroaniline as sulfonamide inhibitor |
| 3RZ5 | 2011-08-10 | 1.65 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 4MLX | 2014-07-02 | 1.65 | Structure of a bidentate 3-hydroxy-4H-pyran-4-thione ligand bound to hCAII |
| 3MNH | 2010-07-14 | 1.65 | Human Carbonic Anhydrase II Mutant K170A |
| 5FNH | 2016-03-02 | 1.66 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 2VVB | 2009-07-14 | 1.66 | Human carbonic anhydrase II in complex with bicarbonate |
| 4M2W | 2013-11-06 | 1.66 | Genetically engineered Carbonic Anhydrase IX in complex with Dorzolamide |
| 1Z9Y | 2006-05-23 | 1.66 | carbonic anhydrase II in complex with furosemide as sulfonamide inhibitor |
| 5FLO | 2016-03-02 | 1.66 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 5FLS | 2016-03-02 | 1.67 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 2CBB | 1993-10-31 | 1.67 | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES |
| 5FNJ | 2016-03-02 | 1.67 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 2CBD | 1993-10-31 | 1.67 | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES |
| 5FLT | 2016-03-02 | 1.67 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 3M3X | 2010-10-20 | 1.68 | Crystal structure of human carbonic anhydrase isozyme II with 4-{2-[N-(6-methoxy-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide |
| 5FLR | 2016-03-02 | 1.68 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 3M1Q | 2011-05-25 | 1.69 | Carbonic Anhydrase II mutant W5C-H64C with opened disulfide bond |
| 5SZ3 | 2016-12-21 | 1.69 | Carbonic anhydrase II in complex with 4-(3-quinolinyl)-benzenesulfonamide |
| 2Q1B | 2007-09-04 | 1.7 | Carbonic Anhydrase II in Complex with Saccharin |
| 3DBU | 2009-03-03 | 1.7 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 4E5Q | 2013-03-27 | 1.7 | Human Carbonic Anhydrase II in complex with cyanate |
| 5FLQ | 2016-03-02 | 1.7 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 5LMD | 2016-10-19 | 1.7 | The crystal structure of hCA II in complex with a benzoxaborole inhibitor |
| 5DOG | 2016-09-28 | 1.7 | Crystal structure of human carbonic anhydrase isozyme II with 2-(Benzylamino)-3,5,6-trifluoro-4-[(2-phenylethyl)thio]benzene- sulfonamide |
| 6MBV | 2019-03-13 | 1.7 | Carbonic Anhydrase II in complex with Nicotinic Acid |
| 1MUA | 1993-10-31 | 1.7 | STRUCTURE AND ENERGETICS OF A NON-PROLINE CIS-PEPTIDYL LINKAGE IN AN ENGINEERED PROTEIN |
| 3MHI | 2010-10-20 | 1.7 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[(5-nitro-6-oxo-1,6-dihydro-4-pyrimidinyl)amino]methyl}benzenesulfonamide |
| 5N0D | 2017-05-10 | 1.7 | Crystal structure of human carbonic anhydrase II in complex with (R)-4-(6,7-dihydroxy-1-phenyl-3,4-tetrahydroisoquinoline-1H-2-carbonyl)benzenesulfonamide. |
| 3HKQ | 2009-10-13 | 1.7 | Human carbonic anhydrase II in complex with 1-S-D-Galactopyranosylsulfonamide |
| 3CYU | 2008-05-27 | 1.7 | Human Carbonic Anhydrase II complexed with Cryptophane biosensor and xenon |
| 5NEE | 2017-12-06 | 1.7 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor 5-[2-(morpholine-4-carbonyl)1,3-oxazol-5-yl)]thiophene-2-sulfonammide |
| 5L6K | 2017-03-01 | 1.7 | Crystal Structure of Human Carbonic Anhydrase II in Complex with a Quinoline Oligoamide Foldamer |
| 4ZWX | 2015-10-28 | 1.7 | Engineered Carbonic Anhydrase IX mimic in complex with glucosyl sulfamate inhibitor |
| 5J8Z | 2016-06-29 | 1.7 | Human carbonic anhydrase II in complex with ligand |
| 3DVB | 2008-11-11 | 1.7 | X-ray crystal structure of mutant N62V human Carbonic Anhydrase II |
| 3C7P | 2009-01-13 | 1.7 | Crystal structure of human carbonic anhydrase II in complex with STX237 |
| 1ZH9 | 2006-05-23 | 1.7 | carbonic anhydrase II in complex with N-4-Methyl-1-piperazinyl-N'-(p-sulfonamide)phenylthiourea as sulfonamide inhibitor |
| 2NWO | 2007-04-24 | 1.7 | Structural and kinetic effect of hydrophobic mutations in the active site of human carbonic anhydrase II |
| 3MHC | 2010-07-21 | 1.7 | Crystal structure of human cabonic anhydrase II in adduct with an adamantyl analogue of acetazolamide in a novel hydrophobic binding pocket |
| 3DC3 | 2009-03-03 | 1.7 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 3DV7 | 2008-11-11 | 1.7 | Role of Hydrophilic Residues in Proton Transfer During Catalysis by Human Carbonic Anhydrase II (N62A) |
| 3U45 | 2012-10-10 | 1.7 | Human Carbonic Anhydrase II V143A |
| 4ITP | 2014-01-01 | 1.7 | Structure of human carbonic anhydrase II bound to a benzene sulfonamide |
| 1YO1 | 2005-09-20 | 1.7 | Proton Transfer from His200 in Human Carbonic Anhydrase II |
| 4K1Q | 2014-04-09 | 1.7 | Structure of hCAIX mimic (hCAII with 5 mutations in active site) |
| 3RZ8 | 2011-08-10 | 1.7 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 3M2Z | 2011-07-06 | 1.7 | Fragment tethered to Carbonic Anhydrase II H64C mutant |
| 4L5W | 2014-04-30 | 1.7 | Structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II |
| 3D8W | 2009-03-03 | 1.7 | Use of a carbonic Anhydrase II, IX Active-site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 3V2J | 2012-12-26 | 1.7 | Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II |
| 3M5E | 2010-10-20 | 1.7 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-chloro-5-formyl-2-methylthiopyrimidin-4-yl)amino]methyl}benzenesulfonamide |
| 4HEW | 2013-10-23 | 1.7 | Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure |
| 3R17 | 2011-05-25 | 1.7 | hCarbonic anhydrase II bound to N-(2-fluoro.4-sulfamoylphenyl)-2-(thiophen-2-yl) acetamide |
| 2NXR | 2007-04-24 | 1.7 | Structural effects of hydrophobic mutations on the active site of human carbonic anhydrase II |
| 1CAM | 1993-10-31 | 1.7 | STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 5FLP | 2016-03-02 | 1.71 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 2F14 | 2006-10-24 | 1.71 | Tne Crystal Structure of the Human Carbonic Anhydrase II in Complex with a Fluorescent Inhibitor |
| 6EEO | 2018-11-28 | 1.72 | Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. |
| 4M2V | 2013-11-06 | 1.72 | Genetically engineered Carbonic Anhydrase IX in complex with Brinzolamide |
| 3V3I | 2012-06-20 | 1.73 | Kinetic and structural studies of thermostabilized mutants of HCA II. |
| 3T5U | 2012-06-20 | 1.75 | Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide |
| 4PYY | 2015-01-28 | 1.75 | Crystal structure of human carbonic anhydrase isozyme II with inhibitor |
| 3SAP | 2012-04-11 | 1.75 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[(5-butyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide |
| 2POW | 2007-07-24 | 1.75 | The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide |
| 3MNI | 2010-07-14 | 1.75 | Human Carbonic Anhydrase II Mutant K170D |
| 5FDC | 2016-05-18 | 1.75 | Crystal structure of Human Carbonic Anhydrase II in complex with the anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog. |
| 1LG5 | 2002-07-24 | 1.75 | Crystal Structure Analysis of the HCA II Mutant T199P in complex with beta-mercaptoethanol |
| 4QJM | 2015-04-15 | 1.75 | Crystal structure of human carbonic anhydrase isozyme II with inhibitor |
| 1ZGF | 2006-05-23 | 1.75 | carbonic anhydrase II in complex with trichloromethiazide as sulfonamide inhibitor |
| 5N0E | 2017-05-10 | 1.75 | Crystal structure of human carbonic anhydrase II in complex with (S)-4-(6,7-dihydroxy-1-phenyl-3,4-tetrahydroisoquinoline-1H-2-carbonyl)benzenesulfonamide. |
| 3S73 | 2011-12-21 | 1.75 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 3MNK | 2010-07-14 | 1.75 | Human Carbonic Anhydrase II Mutant K170H |
| 3MNJ | 2010-07-14 | 1.75 | Human Carbonic Anhydrase II Mutant K170E |
| 3EFI | 2008-09-30 | 1.75 | Carbonic anhydrase activators: Kinetic and X-ray crystallographic study for the interaction of d- and l-tryptophan with the mammalian isoforms I-XIV |
| 4HBA | 2013-07-31 | 1.76 | Structural and Catalytic Characterization of a Thermal and Acid Stable Variant of Human Carbonic Anhydrase II Containing an Engineered Disulfide Bond |
| 1XQ0 | 2005-05-17 | 1.76 | Structure of human carbonic anhydrase II with 4-[(3-bromo-4-O-sulfamoylbenzyl)(4-cyanophenyl)amino]-4H-[1,2,4]-triazole |
| 6E92 | 2019-03-27 | 1.77 | CA IX mimic Complexed with Steroidal Sulfamate Compound STX 2845 |
| 4K0T | 2014-04-09 | 1.78 | Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with chlorzolamide |
| 5SZ7 | 2016-12-21 | 1.78 | Carbonic anhydrase IX-mimic in complex with 4-(3-quinolinyl)-benzenesulfonamide |
| 4ZAO | 2015-10-14 | 1.8 | Genetically engineered Carbonic anhydrase IX |
| 2NXS | 2007-04-24 | 1.8 | Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II |
| 5GMN | 2017-05-24 | 1.8 | Crystal structure of human carbonic anhydrase II in complex with polmacoxib |
| 2NWZ | 2007-04-24 | 1.8 | Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II |
| 3RZ7 | 2011-08-10 | 1.8 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 3CAJ | 2008-04-08 | 1.8 | Crystal structure of the human carbonic anhydrase II in complex with ethoxzolamide |
| 1CAI | 1993-10-31 | 1.8 | STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 2FNK | 2006-11-28 | 1.8 | Activation of Human Carbonic Anhydrase II by exogenous proton donors |
| 4QTL | 2015-04-15 | 1.8 | Crystal structure of human carbonic anhydrase isozyme II with inhibitor |
| 2FNN | 2006-11-28 | 1.8 | Activation of human carbonic anhydrase II by exogenous proton donors |
| 1TG3 | 2005-01-25 | 1.8 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 1I9Q | 2001-03-28 | 1.8 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(3,4,5-TRIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 1YO2 | 2005-09-20 | 1.8 | Proton Transfer from His200 in Human Carbonic Anhydrase II |
| 3HKN | 2009-10-13 | 1.8 | Human carbonic anhydrase II in complex with (2,3,4,6-Tetra-O-acetyl-beta-D-galactopyranosyl) -(1-4)-1,2,3,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosylsulfonamide |
| 4Q49 | 2015-02-25 | 1.8 | Room temperature neutron crystal structure of apo human carbonic anhydrase at pH 7.5 |
| 1RZB | 1993-10-31 | 1.8 | X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES |
| 6E91 | 2019-03-27 | 1.8 | CA IX mimic Complexed with Steroidal Sulfamate Compound STX 2484 |
| 2HD6 | 2006-10-03 | 1.8 | Crystal structure of the human carbonic anhydrase II in complex with a hypoxia-activatable sulfonamide. |
| 3M1J | 2011-01-19 | 1.8 | The crystal structure of a NAMI A-Carbonic Anhydrase II adduct discloses the mode of action of this novel anticancer metallodrug |
| 4Q7S | 2015-03-11 | 1.8 | Crystal Structure of 1-hydroxy-4-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 5O07 | 2017-08-02 | 1.8 | The crystal structure of the human carbonic anhydrase II in complex with a nitroimidazole sulfamate inhibitor |
| 3RZ0 | 2011-08-10 | 1.8 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 4PYX | 2015-01-28 | 1.8 | Crystal structure of human carbonic anhydrase isozyme II with inhibitor |
| 1RAY | 1993-10-31 | 1.8 | THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE |
| 1CNI | 1995-07-10 | 1.8 | X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE |
| 3DCS | 2009-03-03 | 1.8 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 5EOI | 2016-11-23 | 1.8 | Crystal structure of copper bound human Carbonic anhydrase II |
| 1THK | 2005-01-25 | 1.8 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 3PJJ | 2012-01-18 | 1.8 | Synthetic Dimer of Human Carbonic Anhydrase II |
| 2FNM | 2006-11-28 | 1.8 | Activation of human carbonic anhdyrase II by exogenous proton donors |
| 3M67 | 2010-11-03 | 1.8 | Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-[(6,7-dihydro-1H-[1,4]dioxino[2,3-f]benzimidazol-2-ylsulfanyl)acetyl]benzenesulfonamide |
| 3NB5 | 2011-04-20 | 1.8 | Human carbonic anhydrase II in complex with 2-(3-chloro-4-hydroxyphenyl)-N-(4-sulfamoylphenethyl)acetamide |
| 1ZSC | 1996-07-11 | 1.8 | CARBONIC ANHYDRASE II MUTANT E117Q, HOLO FORM |
| 6QFU | 2019-04-17 | 1.8 | Human carbonic anhydrase II with bound IrCp* complex (cofactor 7) to generate an artificial transfer hydrogenase (ATHase) |
| 2NWP | 2007-04-24 | 1.8 | Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II |
| 3MNU | 2010-06-16 | 1.8 | Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron containing aromatic sulfamide with mammalian isoforms I-XV |
| 1YO0 | 2005-09-20 | 1.8 | Proton Transfer from His200 in Human Carbonic Anhydrase II |
| 1CNJ | 1995-07-10 | 1.8 | X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE |
| 3ML2 | 2011-04-20 | 1.8 | Human carbonic anhydsase II in complex with an aryl sulfonamide inhibitor |
| 3T83 | 2011-10-19 | 1.8 | Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates |
| 4XE1 | 2015-03-18 | 1.8 | Human carbonic anhydrase II in complex with 6-SULFAMOYL-SACCHARIN |
| 2WD3 | 2010-02-23 | 1.8 | Highly Potent First Examples of Dual Aromatase-Steroid Sulfatase Inhibitors based on a Biphenyl Template |
| 6BCC | 2018-02-28 | 1.8 | Joint X-ray/neutron structure of human carbonic anhydrase II in complex with ethoxzolamide |
| 4KNI | 2013-11-06 | 1.8 | Crystal structure of human carbonic anhydrase isozyme II with 2-Chloro-4-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide |
| 4K0Z | 2014-04-09 | 1.8 | Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with methazolamide |
| 4K0S | 2014-04-09 | 1.8 | Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with acetazolamide |
| 3HKU | 2009-10-13 | 1.8 | Human carbonic anhydrase II in complex with topiramate |
| 1G52 | 2000-11-08 | 1.8 | CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 3FFP | 2009-08-18 | 1.81 | X ray structure of the complex between carbonic anhydrase II and LC inhibitors |
| 1XEG | 2005-09-27 | 1.81 | Crystal structure of human carbonic anhydrase II complexed with an acetate ion |
| 2CBE | 1993-10-31 | 1.82 | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES |
| 4BF6 | 2014-01-22 | 1.82 | Three dimensional structure of human carbonic anhydrase II in complex with 5-(1-(3-Cyanophenyl)-1H-1,2,3-triazol-4-yl)thiophene-2- sulfonamide |
| 1G45 | 2000-11-08 | 1.83 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE |
| 1G46 | 2000-11-08 | 1.84 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 1I9M | 2001-03-28 | 1.84 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4-DIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 1G4J | 2000-11-08 | 1.84 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE |
| 3EFT | 2009-09-08 | 1.85 | Crystal structure of the complex between Carbonic Anhydrase II and a spin-labeled sulfonamide incorporating TEMPO moiety |
| 4PQ7 | 2014-10-08 | 1.85 | The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide inhibitor |
| 3V3H | 2012-06-20 | 1.85 | Kinetic and structural studies of thermostabilized mutants of HCA II. |
| 1BV3 | 1999-09-28 | 1.85 | HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH UREA |
| 4MO8 | 2013-10-30 | 1.85 | The crystal structure of the human carbonic anhydrase II in complex with N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide |
| 4PXX | 2015-06-10 | 1.85 | Crystal structure of a highly thermal stabilized variant of Human Carbonic Anhydrase II |
| 5FDI | 2016-05-18 | 1.85 | Crystal structure of Human Carbonic Anhydrase II with the anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog. |
| 4FL7 | 2012-08-15 | 1.85 | The crystal structure of human carbonic anhydrase II in complex with N-(Hydroxy)-benzamide |
| 1H9N | 1997-09-17 | 1.85 | H119N CARBONIC ANHYDRASE II |
| 3BET | 2008-10-07 | 1.85 | Crystal structure of the human carbonic anhydrase II in complex with STX 641 at 1.85 angstroms resolution |
| 1G3Z | 2000-11-08 | 1.86 | CARBONIC ANHYDRASE II (F131V) |
| 1I9O | 2001-03-28 | 1.86 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4-TRIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 1G54 | 2000-11-08 | 1.86 | CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE |
| 1G48 | 2000-11-08 | 1.86 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 3S77 | 2011-10-19 | 1.86 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 1I9N | 2001-03-28 | 1.86 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,5-DIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 3M2X | 2011-05-25 | 1.87 | Carbonic Anhydrase II in complex with novel sulfonamide inhibitor |
| 1CAH | 1993-10-31 | 1.88 | STRUCTURE OF COBALT CARBONIC ANHYDRASE COMPLEXED WITH BICARBONATE |
| 2CBC | 1993-10-31 | 1.88 | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES |
| 6EDA | 2018-11-28 | 1.88 | Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. |
| 6EBE | 2018-11-28 | 1.88 | Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. |
| 3B4F | 2008-01-22 | 1.89 | Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies |
| 2X7T | 2010-03-31 | 1.89 | Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors. |
| 5LLH | 2017-08-16 | 1.9 | Crystal structure of human carbonic anhydrase isozyme II with 4-(1,3-Benzothiazol-2-ylthio)-2,3,5,6-tetrafluorobenzenesulfonamide |
| 3BL0 | 2008-01-22 | 1.9 | Carbonic anhydrase inhibitors. Interaction of 2-N,N-Dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies |
| 3F4X | 2009-03-17 | 1.9 | Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules make the difference |
| 2H15 | 2007-03-27 | 1.9 | Carbonic anhydrase inhibitors: Clashing with Ala65 as a means of designing isozyme-selective inhibitors that show low affinity for the ubiquitous isozyme II |
| 1CAO | 1994-01-31 | 1.9 | CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS |
| 1CNX | 1995-11-14 | 1.9 | SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS |
| 1CAJ | 1993-10-31 | 1.9 | STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 2CA2 | 1990-01-15 | 1.9 | CRYSTALLOGRAPHIC STUDIES OF INHIBITOR BINDING SITES IN HUMAN CARBONIC ANHYDRASE II. A PENTACOORDINATED BINDING OF THE SCN-ION TO THE ZINC AT HIGH P*H |
| 3DD8 | 2008-08-12 | 1.9 | Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD-486019 with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies |
| 1RZE | 1993-10-31 | 1.9 | X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES |
| 1LGD | 2002-07-24 | 1.9 | Crystal Structure Analysis of HCA II Mutant T199P in Complex with Bicarbonate |
| 5LLE | 2017-08-16 | 1.9 | Crystal structure of human carbonic anhydrase isozyme II with 4-(1-Adamantylamino)-2,3,5,6-tetrafluorobenzenesulfonamide |
| 1F2W | 2000-06-08 | 1.9 | THE MECHANISM OF CYANAMIDE HYDRATION CATALYZED BY CARBONIC ANHYDRASE II REVEALED BY CRYOGENIC X-RAY DIFFRACTION |
| 1YDB | 1995-02-14 | 1.9 | STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II |
| 4JSZ | 2013-06-19 | 1.9 | Benzenesulfonamide bound to hCAII H94C |
| 1CAN | 1994-01-31 | 1.9 | CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS |
| 3MHL | 2010-10-20 | 1.9 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-methoxy-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide |
| 5A25 | 2015-05-20 | 1.9 | Rational engineering of a mesophilic carbonic anhydrase to an extreme halotolerant biocatalyst |
| 1CAZ | 1993-10-31 | 1.9 | WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE |
| 5JMZ | 2017-05-03 | 1.9 | Carbonic Anhydrase IX-mimic IN Complex WITH U-NO2 |
| 1RZD | 1993-10-31 | 1.9 | X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES |
| 1RZA | 1993-10-31 | 1.9 | X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES |
| 1BCD | 1993-10-31 | 1.9 | X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND A NEW TOPICAL INHIBITOR, TRIFLUOROMETHANE SULPHONAMIDE |
| 1UGE | 1997-04-01 | 1.9 | HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY LEU (A65L) |
| 1CAK | 1993-10-31 | 1.9 | STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 2H4N | 1997-09-17 | 1.9 | H94N CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE |
| 1TG9 | 2005-01-25 | 1.9 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 4JSW | 2013-06-19 | 1.9 | Human carbonic anhydrase II H94C |
| 3K7K | 2010-01-26 | 1.9 | Crystal structure of the complex between Carbonic Anhydrase II and anions |
| 6E8P | 2019-04-03 | 1.9 | CA IX mimic Complexed with Steroidal Sulfamate Compound STX 49 |
| 2HKK | 2007-05-22 | 1.9 | Carbonic anhydrase activators: Solution and X-ray crystallography for the interaction of andrenaline with various carbonic anhydrase isoforms |
| 3RG3 | 2012-02-22 | 1.9 | Crystal structure of the W5E mutant of human carbonic anhydrase II |
| 1CRA | 1994-01-31 | 1.9 | THE COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND THE AROMATIC INHIBITOR 1,2,4-TRIAZOLE |
| 2Q1Q | 2007-09-11 | 1.9 | Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies |
| 1CNG | 1995-07-10 | 1.9 | X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE |
| 1BIC | 1993-10-31 | 1.9 | CRYSTALLOGRAPHIC ANALYSIS OF THR-200-> HIS HUMAN CARBONIC ANHYDRASE II AND ITS COMPLEX WITH THE SUBSTRATE, HCO3- |
| 1RZC | 1993-10-31 | 1.9 | X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES |
| 1RAZ | 1993-10-31 | 1.9 | THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE |
| 1I9P | 2001-03-28 | 1.92 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4,6-TRIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 1I9L | 2001-03-28 | 1.93 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(4-FLUOROPHENYL)METHYL]-BENZAMIDE |
| 1I8Z | 2001-03-28 | 1.93 | CARBONIC ANHYDRASE II COMPLEXED WITH AL-6629 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-METHOXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE |
| 3IBI | 2009-09-22 | 1.93 | The crystal structure of the human carbonic anhydrase II in complex with an aliphatic sulfamate inhibitor |
| 1IF4 | 2001-05-02 | 1.93 | Carbonic Anhydrase II Complexed With 4-fluorobenzenesulfonamide |
| 6H2Z | 2018-12-19 | 1.94 | The crystal structure of human carbonic anhydrase II in complex with 4-(4-phenylpiperidine-1-carbonyl)benzenesulfonamide. |
| 1G53 | 2000-11-08 | 1.94 | CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 1IF8 | 2001-05-02 | 1.94 | Carbonic Anhydrase II Complexed With (S)-N-(3-Indol-1-yl-2-methyl-propyl)-4-sulfamoyl-benzamide |
| 1V9E | 2004-02-10 | 1.95 | Crystal Structure Analysis of Bovine Carbonic Anhydrase II |
| 4QSI | 2015-01-21 | 1.95 | Crystal structure of human carbonic anhydrase isozyme II with 5-{[(4-tert-buthyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}-2-chlorobenzenesulfonamide |
| 1YDC | 1995-02-14 | 1.95 | STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II |
| 3M5T | 2011-05-25 | 1.95 | Fragment tethered to Carbonic Anhydrase II H64C mutant |
| 2Q38 | 2007-10-02 | 1.95 | Carbonic Anhydrase II in complex with Saccharin at 1.95 Angstrom |
| 1TTM | 2004-10-05 | 1.95 | Human carbonic anhydrase II complexed with 667-coumate |
| 1G4O | 2000-11-08 | 1.96 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-PHENYLMETHYLBENZAMIDE |
| 3K2F | 2009-11-17 | 1.98 | Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma |
| 3S78 | 2011-10-19 | 1.98 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 1IF7 | 2001-05-02 | 1.98 | Carbonic Anhydrase II Complexed With (R)-N-(3-Indol-1-yl-2-methyl-propyl)-4-sulfamoyl-benzamide |
| 5L3O | 2017-03-01 | 1.98 | Crystal Structure of Human Carbonic Anhydrase II in Complex with a Quinoline Oligoamide Foldamer |
| 4M2R | 2013-11-06 | 1.99 | Human Carbonic Anhydrase II in complex with Brinzolamide |
| 5EIJ | 2016-11-09 | 1.99 | Carbonic Anhydrase II in complex with Sulfonamide Inhibitor |
| 3F8E | 2009-10-06 | 2.0 | Coumarins are a novel class of suicide carbonic anhydrase inhibitors |
| 1CA2 | 1990-01-15 | 2.0 | REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION |
| 1IF9 | 2001-05-02 | 2.0 | Carbonic Anhydrase II Complexed With N-[2-(1H-Indol-5-yl)-butyl]-4-sulfamoyl-benzamide |
| 4KNJ | 2013-11-06 | 2.0 | Crystal structure of human carbonic anhydrase isozyme II with 2-Chloro-4-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide |
| 2GEH | 2006-06-20 | 2.0 | N-Hydroxyurea, a versatile zinc binding function in the design of metalloenzyme inhibitors |
| 3CA2 | 1990-01-15 | 2.0 | CRYSTALLOGRAPHIC STUDIES OF INHIBITOR BINDING SITES IN HUMAN CARBONIC ANHYDRASE II. A PENTACOORDINATED BINDING OF THE SCN-ION TO THE ZINC AT HIGH P*H |
| 3IEO | 2010-01-26 | 2.0 | The coumarin-binding site in carbonic anhydrase: the antiepileptic lacosamide as an example |
| 3P4V | 2011-04-20 | 2.0 | Human carbonic anhydrase II in complex with (+)-Xylariamide A |
| 1H4N | 1997-09-17 | 2.0 | H94N CARBONIC ANHYDRASE II COMPLEXED WITH TRIS |
| 1HED | 1992-10-15 | 2.0 | STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II |
| 1FSR | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT |
| 1I91 | 2001-03-28 | 2.0 | CARBONIC ANHYDRASE II COMPLEXED WITH AL-6619 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-HYDROXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE |
| 1ZE8 | 2005-10-18 | 2.0 | Carbonic anhydrase II in complex with a membrane-impermeant sulfonamide inhibitor |
| 1FQM | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT |
| 1UGF | 1997-04-01 | 2.0 | HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY THR (A65T) |
| 2ABE | 2005-10-25 | 2.0 | Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators |
| 1ZSB | 1996-07-11 | 2.0 | CARBONIC ANHYDRASE II MUTANT E117Q, TRANSITION STATE ANALOGUE ACETAZOLAMIDE |
| 1TE3 | 2005-01-25 | 2.0 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 1UGA | 1997-01-27 | 2.0 | HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY PHE (A65F) |
| 1TB0 | 2005-01-25 | 2.0 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 1IF5 | 2001-05-02 | 2.0 | Carbonic Anhydrase II Complexed With 2,6-difluorobenzenesulfonamide |
| 1T9N | 2005-01-25 | 2.0 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 1TEU | 2005-01-25 | 2.0 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 1AVN | 1997-12-24 | 2.0 | HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH THE HISTAMINE ACTIVATOR |
| 1UGD | 1997-01-27 | 2.0 | HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY SER (A65S) |
| 3T84 | 2011-10-19 | 2.0 | Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates |
| 4Y0J | 2015-04-22 | 2.0 | H/D exchanged human carbonic anhydrase II pH 6 room temperature neutron crystal structure. |
| 3KKX | 2010-01-12 | 2.0 | Neutron structure of human carbonic anhydrase II |
| 6BBS | 2018-02-28 | 2.0 | Joint X-ray/neutron structure of human carbonic anhydrase II in complex with brinzolamide |
| 1HEB | 1992-10-15 | 2.0 | STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II |
| 3NJ9 | 2011-06-22 | 2.0 | Crystal structure of carbonic anhydrase II in complex with a Nir inhibitor |
| 4M2U | 2013-11-06 | 2.0 | Carbonic Anhydrase II in complex with Dorzolamide |
| 3T82 | 2011-10-19 | 2.0 | Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates |
| 1HEC | 1992-10-15 | 2.0 | STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II |
| 1UGC | 1997-04-01 | 2.0 | HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY HIS (A65H) |
| 1FSQ | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT |
| 4MLT | 2014-07-02 | 2.0 | Structure of a monodentate 3-hydroxy-4H-pyran-4-thione ligand bound to hCAII |
| 1TBT | 2005-01-25 | 2.0 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 3V3F | 2012-06-20 | 2.0 | Kinetic and structural studies of thermostabilized mutants of HCA II. |
| 1CNW | 1995-11-14 | 2.0 | SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS |
| 1FSN | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT |
| 3TMJ | 2011-11-09 | 2.0 | Joint X-ray/neutron structure of human carbonic anhydrase II at pH 7.8 |
| 4G0C | 2012-09-19 | 2.0 | Neutron structure of acetazolamide-bound human carbonic anhydrase II reveal molecular details of drug binding. |
| 1UGB | 1997-01-27 | 2.0 | HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY GLY (A65G) |
| 1AM6 | 1998-06-24 | 2.0 | CARBONIC ANHYDRASE II INHIBITOR: ACETOHYDROXAMATE |
| 1I90 | 2001-03-28 | 2.0 | CARBONIC ANHYDRASE II COMPLEXED WITH AL-8520 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 4-AMINO-3,4-DIHYDRO-2-(3-METHOXYPROPYL)-, 1,1-DIOXIDE, (R) |
| 5BNL | 2015-07-15 | 2.0 | Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins |
| 1FQN | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT |
| 1FQR | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT |
| 2EZ7 | 2006-07-18 | 2.0 | Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII and XIV with L- and D-histidine and crystallographic analysis of their adducts with isoform II: engineering proton transfer processes within the active site of an enzyme |
| 1FQL | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT |
| 1TEQ | 2005-01-25 | 2.0 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 1HEA | 1992-10-15 | 2.0 | CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) (HCA II) (E.C.4.2.1.1) MUTANT WITH LEU 198 REPLACED BY ARG (L198R) |
| 3KWA | 2010-07-14 | 2.0 | Polyamines inhibit carbonic anhydrases |
| 3P55 | 2011-10-12 | 2.0 | Human carbonic anhydrase II in complex with p-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide |
| 4Z1E | 2015-08-26 | 2.01 | Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV) |
| 1XPZ | 2005-05-17 | 2.02 | Structure of human carbonic anhydrase II with 4-[4-O-sulfamoylbenzyl)(4-cyanophenyl)amino]-4H-[1,2,4]-triazole |
| 4CNW | 2015-02-04 | 2.03 | Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture |
| 1G1D | 2000-11-08 | 2.04 | CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE |
| 4L5U | 2014-04-30 | 2.05 | The structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II |
| 1CNH | 1995-07-10 | 2.05 | X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE |
| 5FNG | 2016-03-02 | 2.05 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 1IF6 | 2001-05-02 | 2.09 | Carbonic Anhydrase II Complexed With 3,5-difluorobenzenesulfonamide |
| 2WEH | 2009-11-10 | 2.09 | Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors |
| 1YDA | 1995-02-14 | 2.1 | STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II |
| 4CA2 | 1992-10-31 | 2.1 | ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II |
| 3RGE | 2012-02-22 | 2.1 | Crystal structure of the W5H mutant of human carbonic anhydrase II |
| 3NI5 | 2011-06-22 | 2.1 | Carbonic anhydrase inhibitor: C1 family |
| 1CIM | 1994-01-31 | 2.1 | THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS |
| 1YDD | 1995-02-14 | 2.1 | STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II |
| 1EOU | 2002-02-13 | 2.1 | CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH AN ANTICONVULSANT SUGAR SULFAMATE |
| 5CA2 | 1992-10-31 | 2.1 | CONFORMATIONAL MOBILITY OF HIS-64 IN THE THR-200 (RIGHT ARROW) SER MUTANT OF HUMAN CARBONIC ANHYDRASE II |
| 1BN1 | 1999-05-18 | 2.1 | CARBONIC ANHYDRASE II INHIBITOR |
| 1DCB | 1993-07-15 | 2.1 | STRUCTURE OF AN ENGINEERED METAL BINDING SITE IN HUMAN CARBONIC ANHYDRASE II REVEALS THE ARCHITECTURE OF A REGULATORY CYSTEINE SWITCH |
| 1CIN | 1994-01-31 | 2.1 | THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS |
| 3BL1 | 2008-07-01 | 2.1 | Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited old leads for new applications |
| 1OKL | 1997-01-11 | 2.1 | CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKL INHIBITOR 5-DIMETHYLAMINO-NAPHTHALENE-1-SULFONAMIDE |
| 2HOC | 2006-10-10 | 2.1 | Crystal structure of the human carbonic anhydrase II in complex with the 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide inhibitor |
| 1BN4 | 1999-05-18 | 2.1 | CARBONIC ANHYDRASE II INHIBITOR |
| 1CAY | 1993-10-31 | 2.1 | WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE |
| 2O4Z | 2007-05-15 | 2.1 | Crystal structure of the Carbonic Anhydrase II complexed with hydroxysulfamide inhibitor |
| 3HFP | 2010-05-19 | 2.1 | Crystal structure of teh complex between CA II and the activator MAI |
| 2X7U | 2010-03-31 | 2.12 | Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors. |
| 1BNT | 1999-06-15 | 2.15 | CARBONIC ANHYDRASE II INHIBITOR |
| 5UMC | 2017-12-06 | 2.15 | Synthesis of novel seleno ureido containing compounds as SLC-0111 analogs. Investigations on carbonic anhydrases activity, glutathione peroxidase and X-ray crystallography |
| 1CNK | 1995-07-10 | 2.15 | X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE |
| 1BNU | 1999-06-15 | 2.15 | CARBONIC ANHYDRASE II INHIBITOR |
| 4LP6 | 2013-10-23 | 2.15 | Crystal Structure of Human Carbonic Anhydrase II in complex with a quinoline oligoamide foldamer |
| 1CAL | 1993-10-31 | 2.2 | STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 1H9Q | 1997-09-17 | 2.2 | H119Q CARBONIC ANHYDRASE II |
| 1XEV | 2005-09-20 | 2.2 | Crystal structure of human carbonic anhydrase II in a new crystal form |
| 3IBN | 2009-09-22 | 2.2 | The crystal structure of the human carbonic anhydrase II in complex with an aliphatic bis-sulfamate inhibitor |
| 1CCT | 1995-02-07 | 2.2 | STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY |
| 1DCA | 1993-07-15 | 2.2 | STRUCTURE OF AN ENGINEERED METAL BINDING SITE IN HUMAN CARBONIC ANHYDRASE II REVEALS THE ARCHITECTURE OF A REGULATORY CYSTEINE SWITCH |
| 1CVD | 1994-12-20 | 2.2 | STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE |
| 3P44 | 2011-10-12 | 2.2 | Human carbonic anhydrase II in complex with p-(4-ruthenocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide |
| 1BN3 | 1999-05-18 | 2.2 | CARBONIC ANHYDRASE II INHIBITOR |
| 1CNC | 1994-10-15 | 2.2 | COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES |
| 5CAC | 1994-01-31 | 2.2 | REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION |
| 1OKM | 1997-01-11 | 2.2 | CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKM INHIBITOR 4-SULFONAMIDE-[1-(4-AMINOBUTANE)]BENZAMIDE |
| 5L70 | 2017-06-21 | 2.2 | CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER |
| 4CAC | 1994-01-31 | 2.2 | REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION |
| 1UGG | 1997-01-27 | 2.2 | HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY SER (A65S)-ORTHORHOMBIC FORM |
| 1LG6 | 2002-07-24 | 2.2 | Crystal Structure Analysis of HCA II Mutant T199P in Complex with Thiocyanate |
| 6ECZ | 2018-11-28 | 2.21 | Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. |
| 1KWR | 2003-01-07 | 2.25 | HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH INHIBITOR 0134-36 |
| 1A42 | 1999-03-23 | 2.25 | HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH BRINZOLAMIDE |
| 1CVF | 1994-11-30 | 2.25 | STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE |
| 1CVE | 1994-11-30 | 2.25 | STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE |
| 1BNW | 1999-06-15 | 2.25 | CARBONIC ANHYDRASE II INHIBITOR |
| 1CVA | 1993-10-31 | 2.25 | STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 1CCU | 1995-02-07 | 2.25 | STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY |
| 4CNR | 2015-02-04 | 2.29 | Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture |
| 1CVH | 1995-02-07 | 2.3 | STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE |
| 1CA3 | 1992-10-15 | 2.3 | UNEXPECTED PH-DEPENDENT CONFORMATION OF HIS-64, THE PROTON SHUTTLE OF CARBONIC ANHYDRASE II. |
| 1BNN | 1999-05-18 | 2.3 | CARBONIC ANHYDRASE II INHIBITOR |
| 1CNY | 1995-11-14 | 2.3 | SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS |
| 1HCA | 1992-10-15 | 2.3 | UNEXPECTED PH-DEPENDENT CONFORMATION OF HIS-64, THE PROTON SHUTTLE OF CARBONIC ANHYDRASE II. |
| 1CVC | 1994-01-31 | 2.3 | REDESIGNING THE ZINC BINDING SITE OF HUMAN CARBONIC ANHYDRASE II: STRUCTURE OF A HIS2ASP-ZN2+ METAL COORDINATION POLYHEDRON |
| 1LZV | 2002-10-23 | 2.3 | Site-Specific Mutant (Tyr7 replaced with His) of Human Carbonic Anhydrase II |
| 1HVA | 1993-10-31 | 2.3 | ENGINEERING THE ZINC BINDING SITE OF HUMAN CARBONIC ANHYDRASE II: STRUCTURE OF THE HIS-94-> CYS APOENZYME IN A NEW CRYSTALLINE FORM |
| 1CCS | 1995-02-07 | 2.35 | STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY |
| 1CNB | 1994-10-15 | 2.35 | COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES |
| 3HKT | 2009-10-13 | 2.36 | Human carbonic anhydrase II in complex with alpha-D-Glucopyranosyl-(1->4)-1-thio-beta-D-glucopyranosylsulfonamide |
| 12CA | 1992-10-15 | 2.4 | ALTERING THE MOUTH OF A HYDROPHOBIC POCKET. STRUCTURE AND KINETICS OF HUMAN CARBONIC ANHYDRASE II MUTANTS AT RESIDUE VAL-121 |
| 1OKN | 1997-01-11 | 2.4 | CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKN INHIBITOR 4-SULFONAMIDE-[1-(4-N-(5-FLUORESCEIN THIOUREA)BUTANE)] |
| 3T85 | 2011-10-19 | 2.4 | Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates |
| 7CA2 | 1992-07-15 | 2.4 | ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II |
| 1BNV | 1999-02-16 | 2.4 | CARBONIC ANHYDRASE II INHIBITOR |
| 1BNQ | 1999-06-15 | 2.4 | CARBONIC ANHYDRASE II INHIBITOR |
| 8CA2 | 1992-07-15 | 2.4 | ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II |
| 1CVB | 1993-10-31 | 2.4 | STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 6CA2 | 1992-07-15 | 2.5 | ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II |
| 1ZSA | 1996-07-11 | 2.5 | CARBONIC ANHYDRASE II MUTANT E117Q, APO FORM |
| 1KWQ | 2003-01-07 | 2.6 | HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH INHIBITOR 2000-07 |
| 1BNM | 1999-05-18 | 2.6 | CARBONIC ANHYDRASE II INHIBITOR |
| 5L6T | 2017-06-21 | 2.65 | CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER |
| 9CA2 | 1992-07-15 | 2.8 | ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II |
| 5L9E | 2017-06-21 | 2.9 | CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER |
| 1V9I | 2004-02-10 | 2.95 | Crystal Structure Analysis of the site specific mutant (Q253C) of bovine carbonic anhydrase II |
| 1G6V | 2000-11-22 | 3.5 | Complex of the camelid heavy-chain antibody fragment CAB-CA05 with bovine carbonic anhydrase |