Thermal denaturation of erythrocyte carbonic anhydrase.
Abstract
An experimental study on the thermal behaviour of erythrocyte carbonic anhydrase was carried out with the main aim to estimate the thermodynamic parameters that control the stability of the enzyme. The effects of thermal denaturation on the catalytic properties of the enzyme were also investigated. Below 60 degrees C the enzyme was found to be very stable, whereas between 60 and 65 degrees C a drastic decrease in the biological activity was observed. From the obtained results some considerations were made about the stabilization of the active form of the protein. Study holds ProTherm entries: 10121, 10122 Extra Details: carbonic anhydrase; thermal denaturation; conformational stability;,bovine erythrocytes
Submission Details
ID: 35X8xCNJ4
Submitter: Connie Wang
Submission Date: April 24, 2018, 8:39 p.m.
Version: 1
Publication Details
Lavecchia R;Zugaro M,FEBS Lett. (1991) Thermal denaturation of erythrocyte carbonic anhydrase. PMID:1959599Additional Information
Study Summary
Structure view and single mutant data analysis
Study data
| Colors: | D | E | R | H | K | S | T | N | Q | A | V | I | L | M | F | Y | W | C | G | P |
|---|
Data Distribution
Studies with similar sequences (approximate matches)
Correlation with other assays (exact sequence matches)
Relevant PDB Entries
| Structure ID | Release Date | Resolution | Structure Title |
|---|---|---|---|
| 6QEB | 2019-02-06 | Assessment of a large enzyme-drug complex by proton-detected solid-state NMR without deuteration | |
| 6GCY | 2019-02-06 | Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (saccharin-sugar conjugate complex) | |
| 6FJI | 2019-02-06 | Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (apo). | |
| 5C8I | 2016-07-20 | Joint X-ray/neutron structure of Human Carbonic Anhydrase II in complex with Methazolamide | |
| 6HD2 | 2019-08-28 | Active-site conformational dynamics of carbonic anhydrase II under native conditions: An NMR perspective | |
| 6BC9 | 2018-02-28 | Joint X-ray/neutron structure of human carbonic anhydrase II in complex with dorzolamide | |
| 6FJJ | 2019-02-06 | Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (saccharin). | |
| 3K34 | 2010-05-12 | 0.9 | Human carbonic anhydrase II with a sulfonamide inhibitor |
| 6KM2 | 2020-08-05 | 0.9 | Human Carbonic Anhydrase II V143I variant 15 atm CO2 |
| 3KS3 | 2010-01-26 | 0.9 | High resolution structure of Human Carbonic Anhydrase II at 0.9 A |
| 6B00 | 2017-12-13 | 0.9 | Thermostabilized mutant of human carbonic anhydrase II - A65T L100H K154N L224S L240P A248T |
| 5Y2S | 2018-02-14 | 0.9 | 7.0 atm CO2-pressurized human carbonic anhydrase II |
| 6KLZ | 2020-08-12 | 0.9 | Human Carbonic Anhydrase II V143I variant 00 atm CO2 |
| 6ROB | 2020-04-15 | 0.93 | Human Carbonic Anhydrase II in complex with 4-cyanobenzenesulfonamide |
| 6KM0 | 2020-08-05 | 0.93 | Human Carbonic Anhydrase II V143I variant 07 atm CO2 |
| 3U7C | 2013-02-13 | 0.93 | crystal structure of the V143I mutant of human carbonic anhydrase II |
| 6SBL | 2020-08-26 | 0.94 | Human Carbonic Anhydrase II in complex with 4-hexylbenzenesulfonamide |
| 6ROE | 2020-04-15 | 0.94 | Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide |
| 6RH4 | 2020-04-15 | 0.95 | Human Carbonic Anhydrase II in complex with 4-Nitrobenzenesulfonamide. |
| 6SAY | 2020-04-15 | 0.95 | Human Carbonic Anhydrase II in complex with fragment. |
| 6RQI | 2020-04-15 | 0.95 | Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide |
| 6SBH | 2020-04-08 | 0.95 | Human Carbonic Anhydrase II in complex with 4-pentylbenzenesulfonamide. |
| 6YZN | 2020-10-28 | 0.95 | Closo-carborane butyl-sulfonamide in complex with CA IX mimic |
| 6S9Z | 2020-04-15 | 0.95 | Expression tag modified N-terminus of human Carbonic Anhydrase II covalently linked to fragment |
| 6SBM | 2020-08-26 | 0.95 | Human Carbonic Anhydrase II in complex with 4-(pentyloxy)benzenesulfonamide |
| 1LUG | 2003-09-09 | 0.95 | Full Matrix Error Analysis of Carbonic Anhydrase |
| 6RKN | 2020-04-15 | 0.96 | Human Carbonic Anhydrase II in complex with a fluorinated Benzenesulfonamide. |
| 4YXI | 2016-02-03 | 0.96 | Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (2). |
| 6RFH | 2020-05-13 | 0.97 | Human Carbonic Anhydrase II in complex with 4-Carboxybenzenesulfonamide |
| 6T81 | 2020-10-14 | 0.98 | Human Carbonic anhydrase II bound by 2-Naphthalenesulfonamide. |
| 6SG6 | 2020-08-26 | 0.98 | Human Carbonic Anhydrase II in complex with furan-containing benzenesulfonamide |
| 4FPT | 2013-07-03 | 0.98 | Carbonic Anhydrase II in complex with ethyl (2Z,4R)-2-(sulfamoylimino)-1,3-thiazolidine-4-carboxylate |
| 4FU5 | 2013-07-17 | 0.98 | Carbonic Anhydrase II in complex with N-[(2Z)-1,3-oxazolidin-2-ylidene]sulfuric diamide |
| 4FRC | 2013-07-17 | 0.98 | Carbonic Anhydrase II in complex with N'-sulfamoylpyrrolidine-1-carboximidamide |
| 2FOU | 2006-04-04 | 0.99 | Human Carbonic Anhydrase II complexed with two-prong inhibitors |
| 6YZK | 2020-10-28 | 0.99 | Carborane closo-pentyl-sulfonamide in complex with CA IX mimic |
| 5OGO | 2018-08-01 | 0.99 | Crystal structure of chimeric carbonic anhydrase I with 3-(Benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide |
| 6YZU | 2020-10-28 | 1.0 | Carborane nido-pentyl-sulfonamide in complex with CA II |
| 6SFQ | 2020-08-26 | 1.0 | Atomic resolution structure of human Carbonic Anhydrase II in complex with (R)-5-phenyloxazolidine-2,4-dione |
| 6RIG | 2020-05-13 | 1.0 | Human Carbonic Anhydrase II in complex with 4-Hydroxybenzenesulfonamide |
| 5LJT | 2017-06-21 | 1.0 | Crystal structure of human carbonic anhydrase II in complex with the 4-((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)benzenesulfonamide inhibitor |
| 4MTY | 2013-12-11 | 1.0 | Structure at 1A resolution of a helical aromatic foldamer-protein complex. |
| 6RL9 | 2020-04-15 | 1.0 | Human Carbonic Anhydrase II in complex with 4-Aminobenzenesulfonamide |
| 5Y2R | 2018-02-14 | 1.0 | 2.5 atm CO2-pressurized human carbonic anhydrase II |
| 4Q78 | 2015-03-18 | 1.0 | Structure-assisted design of carborane-based inhibitors of carbonic anhydrase |
| 6RZX | 2020-06-03 | 1.0 | Carbonic Anhydrase CAIX mimic in complex with inhibitor FBSA |
| 2NNO | 2007-05-08 | 1.01 | Structure of inhibitor binding to Carbonic Anhydrase II |
| 6RIT | 2020-04-15 | 1.01 | Human Carbonic Anhydrase II in complex with 2-Fluorobenzenesulfonamide |
| 6G3Q | 2018-11-28 | 1.01 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor famotidine |
| 6NJ3 | 2019-10-02 | 1.01 | Thermostable variant of human carbonic anhydrase with ordered tetrazine 2.0 at site 233 |
| 4YX4 | 2016-02-03 | 1.01 | Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (1). |
| 6SAC | 2020-04-15 | 1.02 | N-terminal expression tag remainder of human Carbonic Anhydrase II covalently modified by fragment |
| 6SDJ | 2020-04-15 | 1.02 | Human Carbonic Anhydrase II in complex with (R)-1-aminopropan-2-ol |
| 6HR3 | 2019-10-09 | 1.02 | Human Carbonic Anhydrase II in complex with 4-Propylbenzenesulfonamide |
| 6SDI | 2020-08-26 | 1.03 | Human Carbonic Anhydrase II in complex with an inhibitor soaked at a concentration of 0.01 mM |
| 6YZW | 2020-10-28 | 1.03 | Carborane closo-hexyl-sulfonamide in complex with CA II |
| 2NNS | 2007-05-08 | 1.03 | Structure of inhibitor binding to Carbonic Anhydrase II |
| 5LL8 | 2017-08-16 | 1.03 | Human Carbonic Anhydrase II in complex with aliphatic Benzenesulfonamide inhibitor. |
| 3V7X | 2012-04-04 | 1.03 | Complex of human carbonic anhydrase II with N-[2-(3,4-dimethoxyphenyl)ethyl]-4-sulfamoylbenzamide |
| 6I0W | 2019-11-20 | 1.04 | Human Carbonic Anhydrase II in complex with 4-Methoxybenzenesulfonamide |
| 6SFU | 2020-08-26 | 1.04 | Human Carbonic Anhydrase II in complex with a furan-containing benzenesulfonamide |
| 6YZQ | 2020-10-28 | 1.04 | Carborane closo-butyl-sulfonamide in complex with CA II |
| 6SDH | 2020-08-26 | 1.04 | Human Carbonic Anhydrase II in complex with an inhibitor soaked at a concentration of 5 mM |
| 6XXT | 2020-06-03 | 1.05 | The crystal structure of hCA II in complex with a 4-(4-aroylpiperazine-1-carbonyl)benzenesulfonamide derivative. |
| 4FVN | 2013-07-17 | 1.05 | Carbonic Anhydrase II in complex with N-(tetrahydropyrimidin-2(1H)-ylidene)sulfuric diamide |
| 2ILI | 2007-06-05 | 1.05 | Refine atomic structure of human carbonic anhydrase II |
| 6YZT | 2020-10-28 | 1.05 | Closo-carborane propyl-sulfonamide in complex with CA II |
| 6SD7 | 2020-04-15 | 1.05 | Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide and its dimer |
| 5LJQ | 2017-06-21 | 1.05 | Crystal structure of human carbonic anhydrase II in complex with the 4-(4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl)benzenesulfonamide inhibitor |
| 6Z04 | 2020-10-28 | 1.05 | Nido-carborane butyl-sulfonamide in complex with CA IX mimic |
| 5DOH | 2016-09-28 | 1.05 | Crystal structure of human carbonic anhydrase isozyme II with 2-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-3,5,6-trifluoro-4-[(2-hydroxyethyl)thio]benzenesulfonamide |
| 6YZS | 2020-10-28 | 1.05 | Carborane closo-pentyl-sulfonamide in complex with CA II |
| 6KM1 | 2020-08-05 | 1.05 | Human Carbonic Anhydrase II V143I variant 13 atm CO2 |
| 3VBD | 2012-04-04 | 1.05 | Complex of human carbonic anhydrase II with 4-(6-methoxy-3,4-dihydroisoquinolin-1-yl)benzenesulfonamide |
| 4FVO | 2013-07-03 | 1.05 | Carbonic Anhydrase II in complex with N-[(2E)-3,4-dihydroquinazolin-2(1H)-ylidene]sulfuric diamide |
| 1MOO | 2002-09-18 | 1.05 | Site Specific Mutant (H64A) of Human Carbonic Anhydrase II at high resolution |
| 4YXO | 2016-02-03 | 1.06 | Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (3). |
| 6RJJ | 2020-04-15 | 1.06 | Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide |
| 4WW6 | 2015-07-01 | 1.06 | Crystal structure of human carbonic anhydrase isozyme II with 2,3,5,6-Tetrafluoro-4-(propylthio)benzenesulfonamide |
| 4PZH | 2015-01-28 | 1.06 | Crystal structure of human carbonic anhydrase isozyme II with 2,3,5,6-tetrafluoro-4[(2-hydroxyethyl)sulfonyl]benzenesulfonamide |
| 6RS5 | 2020-04-15 | 1.07 | Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide |
| 6RNP | 2020-04-15 | 1.07 | Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide |
| 4YYT | 2016-02-03 | 1.07 | Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (5). |
| 6I3E | 2019-11-20 | 1.07 | Human Carbonic Anhydrase II in complex with 4-Butylbenzenesulfonamide |
| 4Q08 | 2015-01-28 | 1.07 | Crystal structure of chimeric carbonic anhydrase XII with inhibitor |
| 5M78 | 2017-12-20 | 1.08 | Human Carbonic Anhydrase II in complex with fragment-like inhibitor. |
| 6GDC | 2019-05-01 | 1.08 | Human Carbonic Anhydrase II in complex with Benzenesulfonamide |
| 4YXU | 2016-02-03 | 1.08 | Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (4). |
| 6I1U | 2019-11-20 | 1.08 | Human Carbonic Anhydrase II in complex with 4-Ethoxybenzenesulfonamide |
| 6SDL | 2020-08-26 | 1.08 | Human Carbonic Anhydrase II in complex with (R)-N-(3-(1H-indol-1-yl)-2-methylpropyl)-4-sulfamoylbenzamide |
| 6RG5 | 2020-05-13 | 1.09 | Human Carbonic Anhydrase II in complex with 4-(2-hydroxyethyl)benzenesulfonamide |
| 6SB7 | 2020-04-15 | 1.09 | Human Carbonic Anhydrase II in complex with fragment. |
| 6RSZ | 2020-04-15 | 1.09 | Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide |
| 6GM9 | 2019-06-19 | 1.09 | Human Carbonic Anhydrase II in complex with 4-Methylbenzenesulfonamide |
| 6RRI | 2020-04-15 | 1.1 | Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide |
| 2WEG | 2009-11-10 | 1.1 | Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors |
| 2NNV | 2007-05-08 | 1.1 | Structure of inhibitor binding to Carbonic Anhydrase II |
| 4WL4 | 2015-10-14 | 1.1 | Crystal structure of human carbonic anhydrase II in complex with the 6-hydroxy-chromene-2-thione inhibitor |
| 5NY6 | 2018-01-17 | 1.1 | Carbonic Anhydrase II Inhibitor RA12 |
| 3SAX | 2012-04-11 | 1.1 | Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-{[(5-ethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide |
| 6HQX | 2019-10-09 | 1.1 | Human Carbonic Anhydrase II in complex with 4-Ethylbenzenesulfonamide |
| 5NY1 | 2018-01-17 | 1.1 | Carbonic Anhydrase II Inhibitor RA10 |
| 6SAS | 2020-04-15 | 1.1 | Human Carbonic Anhydrase II in complex with fragment. |
| 5NXW | 2018-01-17 | 1.1 | Carbonic Anhydrase II Inhibitor RA9 |
| 5DRS | 2016-09-28 | 1.1 | Crystal structure of human carbonic anhydraseisozyme II with 3-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide |
| 5NXV | 2018-01-17 | 1.1 | Carbonic Anhydrase II Inhibitor RA8 |
| 3HS4 | 2009-12-08 | 1.1 | Human carbonic anhydrase II complexed with acetazolamide |
| 3D93 | 2008-09-02 | 1.1 | Apo Human carbonic anhydrase II bound with substrate carbon dioxide |
| 3D92 | 2008-09-02 | 1.1 | Human carbonic anhydrase II bound with substrate carbon dioxide |
| 5OGN | 2018-08-01 | 1.1 | Metalacarborane inhibitors of Carbonic Anhydrase IX |
| 5LLC | 2017-08-16 | 1.1 | Crystal structure of human carbonic anhydrase isozyme II with 3-(Methylamino)-2,5,6-trifluoro-4-[(2-phenylethyl)sulfonyl]benzenesulfonamide |
| 5JGT | 2017-01-11 | 1.1 | Human carbonic anhydrase II (F131Y/L198A) complexed with 1,3-thiazole-2-sulfonamide |
| 4YGJ | 2015-03-25 | 1.1 | NaBr--Interactions between Hofmeister Anions and the Binding Pocket of a Protein |
| 6YZX | 2020-10-28 | 1.1 | Carborane nido-hexyl-sulfonamide in complex with CA II |
| 2FOS | 2006-04-04 | 1.1 | Human Carbonic Anhydrase II complexed with two-prong inhibitors |
| 6YKH | 2020-09-09 | 1.1 | Metala-Carborane di-ethyl-sulfonamide (cis isomer) in complex with CA IX mimic |
| 5OGP | 2018-08-01 | 1.1 | Metalacarborane inhibitors of Carbonic Anhydrase IX |
| 5JGS | 2017-01-11 | 1.11 | Human carbonic anhydrase II (F131Y/L198A) complexed with benzo[d]thiazole-2-sulfonamide |
| 5LL4 | 2017-08-16 | 1.12 | Crystal structure of human carbonic anhydrase isozyme II with 4-(1H-benzimidazol-1-ylacetyl)benzenesulfonamide |
| 6T9Z | 2020-06-17 | 1.12 | Nidocarborane inhibitor of Carbonic Anhydrase IX |
| 4Q6D | 2014-11-26 | 1.12 | Crystal structure of human carbonic anhydrase isozyme II with 4-[(Z)-azepan-1-yldiazenyl]benzenesulfonamide |
| 6G6T | 2019-03-13 | 1.12 | Crystal structure of human carbonic anhydrase isozyme II with N-butyl-2,4-dichloro-5-sulfamoyl-benzamide |
| 4Q6E | 2014-11-26 | 1.12 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[3-(3,5-Dimethyl-1H-pyrazol-1-yl)-3-oxopropyl]amino}benzene-1-sulfonamide |
| 5LLG | 2017-08-16 | 1.12 | Crystal structure of human carbonic anhydrase isozyme II with 4-Propylthiobenzenesulfonamide |
| 6HXD | 2019-10-30 | 1.12 | Human Carbonic Anhydrase II in complex with 4-Butylbenzenesulfonamide |
| 6OTK | 2020-05-06 | 1.12 | Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB10-596B |
| 5JEH | 2017-01-11 | 1.13 | Human carbonic anhydrase II (L198A) complexed with benzo[d]thiazole-2-sulfonamide |
| 6SG0 | 2020-08-26 | 1.13 | Atomic resolution structure of Human Carbonic Anhydrase II in complex with furosemide |
| 6T4O | 2020-10-14 | 1.13 | Human Carbonic anhydrase II bound by 3,5-dimethylbenzenesulfonamide |
| 5EKJ | 2016-01-06 | 1.13 | Human Carbonic Anhydrase II complexed with a two-faced guest |
| 6RRG | 2020-04-15 | 1.13 | Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide |
| 6S9G | 2020-04-15 | 1.14 | Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide |
| 4RUY | 2015-04-22 | 1.14 | Crystal structure of human Carbonic Anhydrase II in complex with 4-propoxybenzenesulfonamide |
| 4RUX | 2015-04-22 | 1.14 | Crystal structure of human Carbonic Anhydrase II in complex with 4-(allyloxy)benzenesulfonamide |
| 2NXT | 2007-04-24 | 1.15 | Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II |
| 5SZ6 | 2016-12-28 | 1.15 | Carbonic anhydrase IX-mimic in complex with 4-(3-formylphenyl)-benzenesulfonamide |
| 4Q06 | 2015-01-28 | 1.15 | Crystal structure of chimeric carbonic anhydrase IX with inhibitor |
| 6IC2 | 2019-05-15 | 1.15 | Polypharmacology of Epacadostat: a Potent and Selective Inhibitor of the Tumor Associated Carbonic Anhydrases IX and XII |
| 4Q07 | 2015-01-28 | 1.15 | Crystal structure of chimeric carbonic anhydrase IX with inhibitor |
| 2FOV | 2006-04-04 | 1.15 | Human Carbonic Anhydrase II complexed with two-prong inhibitors |
| 4HF3 | 2013-10-23 | 1.15 | Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure |
| 6KM4 | 2020-08-05 | 1.15 | Human Carbonic Anhydrase II native 07 atm CO2 |
| 6YOL | 2020-08-19 | 1.15 | Meta-Nidocarborane propyl-sulfonamide in complex with CA IX mimic |
| 6KM6 | 2020-08-05 | 1.15 | Human Carbonic Anhydrase II native 15 atm CO2 |
| 5BYI | 2015-08-05 | 1.15 | Human carbonic anhydrase II with an azobenzene inhibitor (1d) |
| 2EU2 | 2006-07-11 | 1.15 | Human Carbonic Anhydrase II in complex with novel inhibitors |
| 6KM5 | 2020-08-05 | 1.15 | Human Carbonic Anhydrase II native 13 atm CO2 |
| 5JE7 | 2017-01-11 | 1.15 | Human carbonic anhydrase II (F131Y) complexed with benzo[d]thiazole-2-sulfonamide |
| 6KM3 | 2020-08-05 | 1.15 | Human Carbonic Anhydrase II native 00 atm CO2 |
| 3MHO | 2010-10-20 | 1.15 | Crystal structure of human carbonic anhydrase isozyme II with 4-[N-(6-chloro-5-formyl-2-methylthiopyrimidin-4-yl)amino]benzenesulfonamide |
| 4ITO | 2014-03-26 | 1.16 | Human CA II inhibition by novel sulfonamide |
| 3RYY | 2011-08-10 | 1.16 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 5NXI | 2018-01-17 | 1.16 | Carbonic Anhydrase II Inhibitor RA2 |
| 5MJN | 2017-12-06 | 1.17 | Three dimensional structure of human carbonic anhydrase II in complex with 5-[(4Chlorobenzyl)sulfanyl]thiophene-2-sulfonamide |
| 6YO7 | 2020-08-19 | 1.17 | Ortho-Carborane di-propyl-sulfonamide in complex with CA IX mimic |
| 3M2Y | 2011-05-25 | 1.17 | Carbonic Anhydrase II in complex with novel sulfonamide inhibitor |
| 5JG5 | 2017-01-11 | 1.19 | Human carbonic anhydrase II (V121T/F131Y) complexed with benzo[d]thiazole-2-sulfonamide |
| 5JEG | 2017-01-11 | 1.19 | Human carbonic anhydrase II (V121I) complexed with benzo[d]thiazole-2-sulfonamide |
| 5JEP | 2017-01-11 | 1.19 | Human carbonic anhydrase II (T199S) complexed with benzo[d]thiazole-2-sulfonamide |
| 6YKC | 2020-09-09 | 1.2 | Metala-Carborane di-ethyl-sulfonamide (trans isomer) in complex with CA IX mimic |
| 6T7U | 2020-06-17 | 1.2 | Carborane inhibitor of Carbonic Anhydrase IX |
| 5NXG | 2018-01-17 | 1.2 | Carbonic Anhydrase II Inhibitor RA1 |
| 6B4D | 2018-02-07 | 1.2 | Crystal structure of human carbonic anhydrase II in complex with a heteroaryl-pyrazole carboxylic acid derivative. |
| 6YZJ | 2020-10-28 | 1.2 | Closo-carborane ethyl-sulfonamide in complex with CA IX mimic |
| 6YOI | 2020-08-19 | 1.2 | Meta-Carborane di-propyl-sulfonamide in complex with CA IX mimic |
| 6YZL | 2020-10-28 | 1.2 | Closo-carborane methyl-sulfonamide in complex with CA IX mimic |
| 6R6F | 2019-12-18 | 1.2 | Crystal structure of human carbonic anhydrase isozyme II with 4-chloro-2-cyclohexylsulfanyl-N-(2-hydroxyethyl)-5-sulfamoyl-benzamide |
| 6LV9 | 2020-08-19 | 1.2 | Cu- Carbonic Anhydrase II pH 7.8 0 atm CO2 |
| 4Q09 | 2015-01-28 | 1.2 | Crystal structure of chimeric carbonic anhydrase XII with inhibitor |
| 3RYV | 2011-08-10 | 1.2 | Carbonic Anhydrase complexed with N-ethyl-4-sulfamoylbenzamide |
| 6LV6 | 2020-08-19 | 1.2 | Ni- Carbonic Anhydrase II pH 7.8 20 atm CO2 |
| 6LUV | 2020-08-19 | 1.2 | apo- Carbonic Anhydrase II pH 7.8 20 atm CO2 |
| 6I2F | 2019-11-20 | 1.2 | Human Carbonic Anhydrase II in complex with 4-Propoxybenzenesulfonamide |
| 6LUZ | 2020-08-19 | 1.2 | Zn- Carbonic Anhydrase II pH 11.0 20 atm CO2 |
| 6YZR | 2020-10-28 | 1.2 | Carborane nido-butyl-sulfonamide in complex with CA II |
| 6LVA | 2020-08-19 | 1.2 | Cu- Carbonic Anhydrase II pH 7.8 20 atm CO2 |
| 6LV4 | 2020-08-19 | 1.2 | Co- Carbonic Anhydrase II pH 11.0 20 atm CO2 |
| 6LUU | 2020-08-19 | 1.2 | apo- Carbonic Anhydrase II pH 7.8 0 atm CO2 |
| 5T74 | 2017-09-06 | 1.2 | Human carboanhydrase F131C_C206S double mutant in complex with 14 |
| 6LV5 | 2020-08-19 | 1.2 | Ni- Carbonic Anhydrase II pH 7.8 0 atm CO2 |
| 6LV2 | 2020-08-19 | 1.2 | Co- Carbonic Anhydrase II pH 7.8 20 atm CO2 |
| 6LUW | 2020-08-19 | 1.2 | Zn- Carbonic Anhydrase II pH 7.8 0 atm CO2 |
| 5YUI | 2018-08-01 | 1.2 | CO2 release in human carbonic anhydrase II crystals: reveal histidine 64 and solvent dynamics |
| 3RJ7 | 2012-02-29 | 1.2 | Human carbonic anhydrase II complexed with its inhibitor rhenium(I)triscarbonyl-cyclopentadienyl-carboxy-4-aminomethylbenzene-sulfonamide |
| 6LV3 | 2020-08-19 | 1.2 | Co- Carbonic Anhydrase II pH 11.0 0 atm CO2 |
| 6LV1 | 2020-08-19 | 1.2 | Co- Carbonic Anhydrase II pH 7.8 0 atm CO2 |
| 6LV8 | 2020-08-19 | 1.2 | Ni- Carbonic Anhydrase II pH 11.0 20 atm CO2 |
| 6YO2 | 2020-08-19 | 1.2 | Meta-Carborane propyl-sulfonamide in complex with CA IX mimic |
| 6LUX | 2020-08-19 | 1.2 | Zn- Carbonic Anhydrase II pH 7.8 20 atm CO2 |
| 6LUY | 2020-08-19 | 1.2 | Zn- Carbonic Anhydrase II pH 11.0 0 atm CO2 |
| 2NNG | 2007-05-08 | 1.2 | Structure of inhibitor binding to Carbonic Anhydrase II |
| 5NXO | 2018-01-17 | 1.2 | Carbonic Anhydrase II Inhibitor RA6 |
| 6QFW | 2019-04-17 | 1.2 | Human carbonic anhydrase II with bound IrCp* complex (cofactor 9) to generate an artificial transfer hydrogenase (ATHase) |
| 5NYA | 2018-01-17 | 1.2 | Carbonic Anhydrase II Inhibitor RA13 |
| 6LV7 | 2020-08-19 | 1.2 | Ni- Carbonic Anhydrase II pH 11.0 0 atm CO2 |
| 4FIK | 2012-06-27 | 1.2 | Human carbonic anhydrase II H64A complexed with thioxolone hydrolysis products |
| 6D1M | 2018-06-13 | 1.21 | Design, synthesis, and X-ray of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects |
| 5JES | 2017-01-11 | 1.21 | Human carbonic anhydrase II (V121T) complexed with benzo[d]thiazole-2-sulfonamide |
| 5EHV | 2016-03-09 | 1.21 | human carbonic anhydrase II in complex with ligand |
| 5U0F | 2017-08-30 | 1.21 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 5TXY | 2017-08-30 | 1.21 | Identification of a New Zinc Binding Chemotype of by Fragment Screening on human carbonic anhydrase |
| 5JG3 | 2017-01-11 | 1.21 | Human carbonic anhydrase II (121T/N67Q) complexed with benzo[d]thiazole-2-sulfonamide |
| 5EH5 | 2016-03-09 | 1.21 | human carbonic anhydrase II in complex with ligand |
| 6T5C | 2020-10-14 | 1.22 | Human Carbonic anhydrase II bound by anthracene-9-sulfonamide |
| 3L14 | 2011-01-05 | 1.22 | Human Carbonic Anhydrase II complexed with Althiazide |
| 6RMP | 2020-04-15 | 1.22 | Human Carbonic Anhydrase II in complex with fragment. |
| 6PDV | 2020-03-11 | 1.23 | Cu-Carbonic Anhydrase II, A Nitrite Reductase |
| 6SEY | 2020-08-26 | 1.23 | Human Carbonic Anhydrase II in complex with aliphatically substituted benzenesulfonamide |
| 4YGN | 2015-03-25 | 1.23 | NaI--Interactions between Hofmeister Anions and the Binding Pocket of a Protein |
| 4CNX | 2015-02-04 | 1.23 | Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture |
| 6NJ5 | 2019-10-02 | 1.25 | Thermostable variant of human carbonic anhydrase II with disordered tetrazine 2.0 at site 233 |
| 3S71 | 2011-10-19 | 1.25 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 5NXP | 2018-01-17 | 1.25 | Carbonic Anhydrase II Inhibitor RA7 |
| 2FOQ | 2006-02-28 | 1.25 | Human Carbonic Anhydrase II complexed with two-prong inhibitors |
| 6RG4 | 2020-05-13 | 1.25 | Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(2-benzyl-4-methylpiperazin-1-yl)benzenesulfonamide |
| 6YOK | 2020-08-19 | 1.25 | Para-Carborane di-propyl-sulfonamide in complex with CA IX mimic |
| 5YUJ | 2018-08-01 | 1.25 | CO2 release in human carbonic anhydrase II crystals: reveal histidine 64 and solvent dynamics |
| 5NXM | 2018-05-30 | 1.25 | Carbonic Anhydrase II Inhibitor RA1 |
| 6SDS | 2020-06-10 | 1.26 | HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A SULFONAMIDE INHIBITOR |
| 5WEX | 2017-10-11 | 1.26 | Discovery of new selenoureido analogs of 4-(4-fluorophenylureido) benzenesulfonamides as carbonic anhydrase inhibitors |
| 6OUD | 2020-05-06 | 1.26 | Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB11-694B |
| 3GZ0 | 2009-07-21 | 1.26 | Apo-human carbonic anhydrase II revisited: Implications of the loss of a metal in protein structure, stability and solvent network |
| 4Z1J | 2015-08-26 | 1.27 | Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV) |
| 5U0E | 2017-08-30 | 1.27 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 5SZ5 | 2016-12-28 | 1.27 | Carbonic anhydrase IX-mimic in complex with 4-(2-methylphenyl)-benzenesulfonamide |
| 6C7W | 2018-05-23 | 1.28 | Carbonic anhydrase 2 in complex with [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDRO-2-FURANYL]METHYL SULFAMATE inhibitor |
| 5G0C | 2016-05-25 | 1.28 | An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C |
| 7JNZ | 2020-11-04 | 1.29 | Carbonic Anhydrase II Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)cyclohexanecarboxamide |
| 7JNX | 2020-11-04 | 1.29 | Carbonic Anhydrase II Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)pivalamide |
| 7JNW | 2020-11-04 | 1.29 | Carbonic Anhydrase II Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)isobutyramide |
| 3S9T | 2012-04-18 | 1.3 | Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-{[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide |
| 6UGQ | 2019-12-18 | 1.3 | Human Carbonic Anhydrase IX-mimic complexed with SB4-206 |
| 6NJ4 | 2019-10-02 | 1.3 | Thermostable variant of human carbonic anhydrase with disordered tetrazine 2.0 reacted with strained trans-cyclooctene at site 233 |
| 6WQ9 | 2020-06-24 | 1.3 | Carbonic Anhydrase II Complexed with 3-((2-((Naphthalen-2-ylmethyl)(4-sulfamoylphenethyl)amino)-2-oxoethyl)(phenethyl)amino)propanoic acid |
| 5T72 | 2017-09-06 | 1.3 | Human carboanhydrase F131C_C206S double mutant in complex with 2 |
| 6WQ7 | 2020-06-24 | 1.3 | Carbonic Anhydrase II Complexed with 2-((3-Aminopropyl)(phenethyl)amino)-N-(4-fluorobenzyl)-N-(4-sulfamoylphenethyl)acetamide |
| 3S8X | 2012-04-11 | 1.3 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[(4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide |
| 6QL2 | 2019-09-25 | 1.3 | Crystal structure of chimeric carbonic anhydrase VI with ethoxzolamide. |
| 6SYS | 2020-10-14 | 1.3 | Crystal structure of (3aR,4S,9bS)-4-(4-hydroxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide with carbonic anhydrase 2 |
| 4RH2 | 2015-11-11 | 1.3 | Crystal structure of human carbonic anhydrase II in complex with 2-(6-hydroxy-3-Oxo-3H-xanthen-9-yl)-5-{3-1-(4-sulfamoyl-phenyl)-1h-[1,2,3]triazol-4-ylmethyl-thioureido}-benzoic acid |
| 5T71 | 2017-09-06 | 1.3 | Human carboanhydrase F131C_C206S double mutant in complex with SA-2 |
| 6GXE | 2019-05-08 | 1.3 | Carbonic Anhydrase CAIX mimic in complex with inhibitor JS14 |
| 5NEA | 2017-12-06 | 1.3 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(2-methyl-1,3-oxazol-5-yl)benzene-1-sulfonammide |
| 6WQ5 | 2020-06-24 | 1.3 | Carbonic Anhydrase II Complexed with 2-((3-Aminopropyl)(phenethyl)amino)-N-(furan-2-ylmethyl)-N-(4-sulfamoylphenethyl)acetamide |
| 5DSR | 2016-05-04 | 1.3 | Structure of CO2 released apo-form of human carbonic anhydrase II with 10 min warming |
| 5E28 | 2016-01-20 | 1.3 | Crystal structure of human carbonic anhydrase II in complex with the 4-(4-aminophenyl)benzenesulfonamide inhibitor |
| 5N1S | 2017-12-27 | 1.3 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(1H-Indol-2-yl)-benzenesulfonamide |
| 5N1R | 2017-12-27 | 1.3 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4'-Pyrazol-1-ylmethyl-biphenyl-4-sulfonamide |
| 4QIY | 2015-04-15 | 1.3 | Crystal structure of human carbonic anhydrase isozyme II with inhibitor |
| 3PYK | 2011-07-13 | 1.3 | Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor |
| 5DSK | 2016-05-04 | 1.3 | Structure of CO2 released holo-form of human carbonic anhydrase II with 3 min warming |
| 6OE0 | 2019-06-12 | 1.3 | Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects |
| 5DSM | 2016-05-04 | 1.3 | Structure of CO2 released holo-form of human carbonic anhydrase II with 25 min warming |
| 6ODZ | 2019-06-12 | 1.3 | Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects |
| 6UGP | 2019-12-18 | 1.31 | Human Carbonic Anhydrase 2 complexed with SB4-206 |
| 6OTM | 2020-05-06 | 1.31 | Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB10-586B |
| 6H3Q | 2019-07-17 | 1.31 | Crystal structure of human carbonic anhydrase II in complex with the 4-(5-(chloromethyl)-1,3-selenazol-2-yl)benzenesulfonamide |
| 6UGR | 2019-12-18 | 1.31 | Human Carbonic Anhydrase 2 complexed with SB4-208 |
| 6UH0 | 2019-12-18 | 1.31 | Human Carbonic Anhydrase 2 in complex with SB4-202 |
| 7JO2 | 2020-11-04 | 1.31 | Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)isobutyramide |
| 6UGZ | 2019-12-18 | 1.31 | Human Carbonic Anhydrase IX-mimic complexed with SB4-208 |
| 3ZP9 | 2013-10-30 | 1.31 | Human Carbonic Anhydrase II as a Scaffold for an Artificial Transfer Hydrogenase |
| 6U4Q | 2020-01-22 | 1.31 | Carbonic anhydrase 2 in complex with SB4197 |
| 6QFX | 2019-04-17 | 1.32 | Human carbonic anhydrase II with bound IrCp* complex (cofactor 10) to generate an artificial transfer hydrogenase (ATHase) |
| 5ZXW | 2018-06-13 | 1.32 | Crystal structure of human carbonic anhydrase II crystallized by ammonium sulfate |
| 6RG3 | 2020-05-13 | 1.32 | Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(2-benzylpiperazin-1-yl)benzenesulfonamide |
| 5THN | 2017-04-26 | 1.33 | Crystal Structure of 2-Hydroxycyclohepta-2,4,6-triene-1-thione bound to human carbonic anhydrase 2 |
| 5EKM | 2016-01-06 | 1.33 | Human Carbonic Anhydrase II complexed with a two-faced guest |
| 6UFC | 2020-08-05 | 1.33 | Carbonic anhydrase 2 with inhibitor (2Z)-2-[(4-methoxyphenyl)methylidene]-3-oxo-N-(4-sulfamoylphenyl)butanamide (11d/D4) |
| 4HEZ | 2013-10-23 | 1.34 | Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure |
| 5JDV | 2017-01-11 | 1.34 | Human carbonic anhydrase II (F131W) complexed with benzo[d]thiazole-2-sulfonamide |
| 5EKH | 2016-01-06 | 1.34 | Human Carbonic Anhydrase II complexed with a two-faced guest |
| 4Z1K | 2015-08-26 | 1.35 | Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV) |
| 5ULN | 2017-10-11 | 1.35 | Synthesis of novel seleno ureido containing compounds as SLC-0111 analogs. Investigations on carbonic anhydrases activity, glutathione peroxidase and X-ray crystallography |
| 4KUV | 2014-06-25 | 1.35 | Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(4-chlorophenylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor |
| 3KNE | 2011-05-18 | 1.35 | Carbonic Anhydrase II H64C mutant in complex with an in situ formed triazole |
| 6GXB | 2019-05-08 | 1.35 | Carbonic Anhydrase CAIX mimic in complex with inhibitor JS13 |
| 6YZP | 2020-10-28 | 1.35 | Carborane nido-hexyl-sulfonamide in complex with CA IX mimic |
| 6VJ3 | 2020-03-11 | 1.35 | Carbonic Anhydrase II in complex with pyrimidine-based inhibitor |
| 4BF1 | 2014-01-22 | 1.35 | Three dimensional structure of human carbonic anhydrase II in complex with 5-(1-naphthalen-1-yl-1,2,3-triazol-4-yl)thiophene-2-sulfonamide |
| 4MDG | 2014-01-01 | 1.35 | Closo Carborane Carbonic Anhydrase Inhibitor |
| 3M1K | 2010-11-17 | 1.35 | Carbonic Anhydrase in complex with fragment |
| 6QL3 | 2019-09-25 | 1.35 | Crystal structure of chimeric carbonic anhydrase VI with 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide |
| 4QK3 | 2015-03-04 | 1.35 | Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - [delta]230-240 |
| 5G03 | 2016-05-25 | 1.35 | An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C |
| 3MYQ | 2011-02-02 | 1.35 | Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-[(1H-imidazo[4,5-c]quinolin-2-ylsulfanyl)acetyl]benzenesulfonamide |
| 6WQ4 | 2020-06-24 | 1.35 | Carbonic Anhydrase II Complexed with 2-((2-Cyanoethyl)(phenethyl)amino)-N-phenethyl-N-(4-sulfamoylphenethyl)acetamide |
| 6PEA | 2020-03-11 | 1.36 | High Resolution Apo Carbonic Anhydrase II |
| 6OUF | 2020-05-06 | 1.36 | Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB11-707A |
| 6UX1 | 2020-04-22 | 1.36 | Carbonic Anhydrase II Complexed with Salicylic Acid |
| 6PGX | 2019-08-21 | 1.36 | Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity |
| 5AML | 2015-04-08 | 1.36 | Three dimensional structure of human carbonic anhydrase II in complex with 2-(But-2-yn-1-ylsulfamoyl)-4-sulfamoylbenzoic acid |
| 6U4T | 2020-01-22 | 1.36 | Carbonic anhydrase 9 in complex with SB4197 |
| 5JQT | 2016-10-19 | 1.36 | Crystal structure of human carbonic anhydrase II in complex with Benzoxaborole at pH 7.4 |
| 3RYZ | 2011-08-10 | 1.37 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 6VKG | 2020-03-04 | 1.37 | Human carbonic anhydrase IX mimic with Epacadostat bound |
| 7JOB | 2020-11-04 | 1.38 | Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)cyclohexanecarboxamide |
| 7JOC | 2020-11-04 | 1.38 | Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)adamantanecarboxamide |
| 5EH8 | 2016-03-09 | 1.38 | human carbonic anhydrase II in complex with ligand |
| 3M1W | 2011-05-25 | 1.38 | Carbonic Anhyrdase II mutant W5CH64C with closed disulfide bond in complex with sulfate |
| 3M14 | 2011-05-25 | 1.38 | Carbonic Anhydrase II in complex with novel sulfonamide inhibitor |
| 6S03 | 2020-06-03 | 1.38 | Carbonic Anhydrase CAIX mimic in complex with inhibitor I39LT379 |
| 3RYJ | 2011-08-10 | 1.39 | Carbonic Anhydrase complexed with 4-sulfamoyl-N-(2,2,2-trifluoroethyl)benzamide |
| 5VGY | 2017-08-30 | 1.39 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 5EHW | 2016-03-09 | 1.39 | human carbonic anhydrase II in complex with ligand |
| 5WLU | 2018-08-01 | 1.39 | Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide |
| 3KIG | 2010-11-17 | 1.39 | Mutant carbonic anhydrase II in complex with an azide and an alkyne |
| 6T4N | 2020-10-14 | 1.4 | Human Carbonic anhydrase II bound by 2,4,6-trimethylbenzenesulfonamide |
| 5NY3 | 2018-01-17 | 1.4 | Carbonic Anhydrase II Inhibitor RA11 |
| 2WEO | 2009-11-10 | 1.4 | Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors |
| 5G01 | 2016-05-25 | 1.4 | An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C |
| 5JQ0 | 2016-10-19 | 1.4 | Crystal structure of human carbonic anhydrase II in complex with Benzoxaborole at pH=8.7 |
| 3M04 | 2011-05-25 | 1.4 | Carbonic Anhydrase II in complex with novel sulfonamide inhibitor |
| 2QO8 | 2008-01-22 | 1.4 | Crystal structure of the complex of hcaii with an indane-sulfonamide inhibitor |
| 5BRW | 2015-06-17 | 1.4 | Catalytic Improvement of an Artificial Metalloenzyme by Computational Design |
| 3SBI | 2012-04-11 | 1.4 | Crystal structure of human carbonic anhydrase isozyme II with 4-[(2-pyrimidinylsulfanyl)acetyl]benzenesulfonamide |
| 4QSB | 2015-01-21 | 1.4 | Crystal structure of human carbonic anhydrase isozyme II with 3-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}benzenesulfonamide |
| 3S74 | 2011-10-19 | 1.4 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 5WLV | 2018-08-01 | 1.4 | Carbonic Anhydrase II in complex with aryloxy-2-hydroxypropylammine sulfonamide |
| 6D1L | 2018-06-13 | 1.4 | Design, synthesis, and X-ray of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects |
| 3M96 | 2011-02-02 | 1.4 | Crystal structure of human carbonic anhydrase isozyme II with 5-{[(5-bromo-1H-benzimidazol-2-yl)sulfanyl]acetyl}-2-chlorobenzenesulfonamide |
| 3MWO | 2010-06-09 | 1.4 | Human carbonic anhydrase II in a doubled monoclinic cell: a re-determination |
| 5DSP | 2016-05-04 | 1.4 | Structure of CO2 released apo-form of human carbonic anhydrase II with 40 sec warming |
| 5E2K | 2016-01-20 | 1.4 | Crystal structure of human carbonic anhydrase II in complex with the 4-(3-aminophenyl)benzenesulfonamide inhibitor |
| 6WQ8 | 2020-06-24 | 1.4 | Carbonic Anhydrase II Complexed with 3-((2-((Furan-2-ylmethyl)(4-sulfamoylphenethyl)amino)-2-oxoethyl)(phenethyl)amino)propanoic acid |
| 5N25 | 2017-12-27 | 1.4 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-Pyridin-3-yl-benzenesulfonamide |
| 5DSO | 2016-05-04 | 1.4 | Structure of CO2 bound apo-form of human carbonic anhydrase II with 0 sec (no) warming |
| 3M5S | 2011-05-25 | 1.4 | Carbonic Anhydrase II mutant H64C in complex with carbonate |
| 6UGN | 2019-12-18 | 1.41 | Human Carbonic Anhydrase 2 complexed with SB4-205 |
| 6OUE | 2020-05-06 | 1.41 | Carbonic Anhydrase II complexed with benzene sulfonamide MB11-707A |
| 3IBU | 2009-09-22 | 1.41 | The crystal structure of the human carbonic anhydrase II in complex with an aliphatic sulfamate inhibitor |
| 5LVS | 2017-03-08 | 1.42 | Self-assembled protein-aromatic foldamer complexes with 2:3 and 2:2:1 stoichiometries |
| 5EH7 | 2016-03-09 | 1.42 | human carbonic anhydrase II in complex with ligand |
| 5TI0 | 2017-04-26 | 1.42 | Crystal Structure of 2-Hydroxycyclohepta-2,4,6-triene-1-thione bound to human carbonic anhydrase 2 L198G |
| 6QL1 | 2019-09-25 | 1.42 | Crystal structure of chimeric carbonic anhydrase VI with 4-[(4,6-dimethylpyrimidin-2-yl)thio]-2,3,5,6-tetrafluorobenzenesulfonamide |
| 6OUB | 2020-05-06 | 1.42 | Carbonic Anhydrase II complexed with benzene sulfonamide MB11-694B |
| 6SX9 | 2020-10-07 | 1.43 | Crystal structure of carbonic anhydrase 2 with 4-(2-chlorophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide |
| 6CEH | 2018-05-23 | 1.43 | Design, Synthesis, X-ray and Biological Activities of Selenides Bearing the Benzenesulfonamide Moiety as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology |
| 6RHK | 2020-05-13 | 1.44 | The crystal structure of human carbonic anhydrase II in complex with 4-(3-benzylimidazolidine-1-carbonyl)benzenesulfonamide |
| 6HX5 | 2018-12-26 | 1.44 | Selenols: a new class of Carbonic Anhydrase inhibitors |
| 6NM0 | 2020-01-15 | 1.44 | Selective inhibition of carbonic anhydrase IX activity, using compound SLC-149, displays limited anticancer effects in breast cancer cell lines |
| 7JNR | 2020-11-04 | 1.44 | Carbonic Anhydrase II Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)propionamide |
| 3HLJ | 2010-03-02 | 1.44 | Crystal structure of human carbonic anhydrase isozyme II with 3-methylthiobenzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonamide |
| 6RHJ | 2020-05-13 | 1.44 | Crystal structure of human carbonic anhydrase isozyme II with 4-(4-benzyl-1,4-diazepane-1-carbonyl)benzenesulfonamide |
| 5TY8 | 2017-08-30 | 1.45 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 5WG7 | 2018-02-07 | 1.45 | Human Carbonic Anhydrase II complexed with AceK |
| 5YUK | 2018-08-01 | 1.45 | CO2 release in human carbonic anhydrase II crystals: reveal histidine 64 and solvent dynamics |
| 7JO3 | 2020-11-04 | 1.45 | Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)pivalamide |
| 4Q8Y | 2015-03-11 | 1.45 | Crystal structure of 2-hydroxyisoquinoline-1(2H)-thione bound to human carbonic anhydrase II |
| 6OUH | 2020-05-06 | 1.45 | Carbonic Anhydrase II mimic complexed with benzene sulfonamide MB11-710A |
| 4E49 | 2012-06-27 | 1.45 | Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors |
| 4YWP | 2015-10-14 | 1.45 | Sucrose Binding Site in genetically engineered Carbonic anhydrase IX |
| 2WEJ | 2009-11-10 | 1.45 | Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors |
| 3OKV | 2011-07-06 | 1.45 | Human Carbonic Anhydrase II A65S, N67Q (CA IX mimic) bound with 2-Ethylestrone 3-O-sulfamate |
| 6QFV | 2019-04-17 | 1.45 | Human carbonic anhydrase II with bound IrCp* complex (cofactor 8) to generate an artificial transfer hydrogenase (ATHase) |
| 4HEY | 2013-10-23 | 1.45 | Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure |
| 4Q7W | 2015-03-11 | 1.45 | Crystal structure of 1-hydroxy-6-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 4Z0Q | 2015-08-26 | 1.45 | Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV) |
| 3OIM | 2011-07-06 | 1.45 | Human Carbonic anhydrase II bound by 2-Ethylestradiol 3-O-sulfamate |
| 2QP6 | 2008-06-03 | 1.45 | The crystal structure of the complex of hcaII with a bioreductive antitumor derivative |
| 4CQ0 | 2014-04-16 | 1.45 | Cyclic secondary sulfonamides: unusually good inhibitors of cancer- related carbonic anhydrase enzymes |
| 4E4A | 2012-06-27 | 1.45 | Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors |
| 4YVY | 2016-03-30 | 1.45 | Crystal structure of human carbonic anhydrase II in complex with hydroxylamine-O-sulfonamide, a molecule incorporating two zinc-binding groups. |
| 4KAP | 2013-07-10 | 1.45 | The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand |
| 6H6S | 2019-01-09 | 1.45 | Sad phasing on nickel-substituted human carbonic anhydrase II |
| 6OE1 | 2019-06-12 | 1.45 | Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects |
| 5DSL | 2016-05-04 | 1.45 | Structure of CO2 released holo-form of human carbonic anhydrase II with 10 min warming |
| 3OKU | 2011-07-06 | 1.45 | Human Carbonic Anhydrase II in complex with 2-Ethylestrone-3-O-sulfamate |
| 6H29 | 2018-09-05 | 1.46 | HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BENZYL CARBAMATE |
| 6UGO | 2019-12-18 | 1.46 | Human Carbonic Anhydrase IX-mimic complexed with SB4-205 |
| 2AW1 | 2006-07-04 | 1.46 | Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor Celecoxib |
| 2GD8 | 2007-02-06 | 1.46 | Crystal structure analysis of the human carbonic anhydrase II in complex with a 2-substituted estradiol bis-sulfamate |
| 4QEF | 2014-10-08 | 1.47 | Human Carbonic Anhydrase II V207I - cyanate inhibitor complex |
| 3QYK | 2012-03-07 | 1.47 | Human Carbonic Anhydrase II complexed with triple ring benzene sulfonamide inhibitor |
| 3PO6 | 2011-04-06 | 1.47 | Crystal structure of human carbonic anhydrase II with 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide |
| 5TH4 | 2017-04-26 | 1.47 | Crystal Structure of 1-hydroxypyridine-2(1H)-thione bound to human carbonic anhydrase 2 L198G |
| 6OUJ | 2020-05-06 | 1.47 | Carbonic Anhydrase II complexed with benzene sulfonamide MB11-689A |
| 6OTP | 2020-05-06 | 1.47 | Carbonic Anhydrase II complexed with ureic benzene sulfonamide MB10-586B |
| 4Z1N | 2015-08-26 | 1.47 | Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV) |
| 6OTQ | 2020-05-06 | 1.47 | Carbonic Anhydrase II complexed with ureic benzene sulfonamide MB10-596B |
| 3V2M | 2012-12-26 | 1.47 | Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II |
| 3OYQ | 2011-08-10 | 1.47 | Structure of Human Carbonic Anhydrase II complexed with 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE |
| 6UFD | 2020-08-05 | 1.48 | Carbonic anhydrase 2 with inhibitor (2Z)-3-oxo-N-(4-sulfamoylphenyl)-2-[(thiophen-2-yl)methylidene]butanamide (11g/D7) |
| 3DD0 | 2009-03-03 | 1.48 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 6YQU | 2020-07-01 | 1.48 | CRYSTAL STRUCTURE OF HUMAN CA II IN COMPLEX WITH 2-MERCAPTOBENZOXAZOLE |
| 7JNV | 2020-11-04 | 1.49 | Carbonic Anhydrase II Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)butyramide |
| 4DZ9 | 2013-03-27 | 1.49 | hCA II in complex with novel sulfonamide inhibitors Set D |
| 2WD2 | 2010-03-31 | 1.49 | A chimeric microtubule disruptor with efficacy on a taxane resistant cell line |
| 5WLR | 2018-08-01 | 1.49 | Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide |
| 3P58 | 2011-10-19 | 1.49 | Human Carbonic Anhydrase in complex with Benzyl (Methyl) Carbamodithoic Acid |
| 4DZ7 | 2013-03-27 | 1.49 | hCA II in complex with novel sulfonamide inhibitors Set D |
| 3P5A | 2011-10-19 | 1.49 | Human Carbonic Anhydrase complexed with Sodium morpholinocarbodithioate |
| 3DCW | 2009-03-03 | 1.5 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 3OIL | 2011-07-06 | 1.5 | Human Carbonic anhydrase II mutant A65S, N67Q (CA IX mimic) bound by 2-Ethylestradiol 3-O-sulfamate |
| 1OQ5 | 2004-03-23 | 1.5 | CARBONIC ANHYDRASE II IN COMPLEX WITH NANOMOLAR INHIBITOR |
| 4E3F | 2012-06-27 | 1.5 | Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors |
| 6OTO | 2020-05-06 | 1.5 | Carbonic Anhydrase II complexed with ureic benzene sulfonamide MB9-561B |
| 3N3J | 2011-03-09 | 1.5 | Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor |
| 3KOK | 2010-08-25 | 1.5 | Crystal structure of cobalt (II) human carbonic anhydrase II at pH 8.5 |
| 3KON | 2010-08-25 | 1.5 | Crystal structure of cobalt (II) human carbonic anhydrase II at pH 11.0 |
| 6YZO | 2020-10-28 | 1.5 | Carborane closo-hexyl-sulfonamide in complex with CA IX mimic |
| 3TVN | 2012-08-08 | 1.5 | Human Carbonic Anhydrase II Proton Transfer Mutant |
| 5T75 | 2017-09-06 | 1.5 | Human carbonic anhydrase II G132C_C206S double mutant in complex with SA-2 |
| 4E3H | 2012-06-27 | 1.5 | Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors |
| 3M98 | 2011-03-02 | 1.5 | Crystal structure of human carbonic anhydrase isozyme II with 5-(1H-benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide |
| 5N24 | 2017-12-27 | 1.5 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor b4'-Cyano-biphenyl-4-sulfonic acid amide |
| 4Q8Z | 2015-03-11 | 1.5 | Crystal structure of 1-hydroxy-4-methylpyridin-2(1H)-one bound to human carbonic anhydrase II |
| 5TYA | 2017-08-30 | 1.5 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 5EHE | 2016-11-09 | 1.5 | Crystal structure of human carbonic anhydrase isozyme II with 3-(benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide |
| 3S75 | 2011-10-19 | 1.5 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 4ZX1 | 2015-10-28 | 1.5 | Engineered Carbonic Anhydrase IX mimic in complex with a glucosyl sulfamate inhibitor |
| 4R5B | 2014-10-15 | 1.5 | Human Carbonic Anhydrase II in Complex with a Carbohydrate-Based Sulfamate |
| 4BCW | 2013-02-06 | 1.5 | Carbonic anhydrase IX mimic in complex with (E)-2-(5-bromo-2- hydroxyphenyl)ethenesulfonic acid |
| 4YGK | 2015-03-25 | 1.5 | NaSCN--Interactions between Hofmeister Anions and the Binding Pocket of a Protein |
| 1FR7 | 2001-01-17 | 1.5 | X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT |
| 4ZWY | 2015-08-05 | 1.5 | Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor |
| 3MZC | 2011-03-09 | 1.5 | Human carbonic ahydrase II in complex with a benzenesulfonamide inhibitor |
| 5AMD | 2015-04-08 | 1.5 | Three dimensional structure of human carbonic anhydrase II in complex with 2-((2-Phenylethyl)sulfamoyl)-4-sulfamoylbenzoic acid |
| 2AX2 | 2006-01-03 | 1.5 | Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II |
| 3V5G | 2012-07-25 | 1.5 | Crystal structure of human carbonic anhydrase II in complex with the 4-sulfamido-benzenesulfonamide inhibitor |
| 4QSA | 2015-01-21 | 1.5 | Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-4-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}benzenesulfonamide |
| 4QY3 | 2014-12-03 | 1.5 | THE CRYSTAL STRUCTURE OF THE COMPLEX of HCAII WITH AN ORTHO-SUBSTITUTED BENZOIC ACID |
| 6MBY | 2019-03-13 | 1.5 | Carbonic Anhydrase II in complex with Ferulic Acid |
| 3MNA | 2011-04-20 | 1.5 | The crystal structure of human carbonic anhydrase Ii in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor |
| 5THI | 2017-04-26 | 1.5 | Crystal Structure of 2-hydroxycyclohepta-2,4,6-trien-1-one bound to human carbonic anhydrase 2 L198G |
| 5TFX | 2017-08-09 | 1.5 | New method for synthesis of benzoxazole amide inhibitors of carbonic anhydrase |
| 3P3H | 2011-09-21 | 1.5 | Human carbonic anhydrase II in complex with p-(5-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide |
| 3N0N | 2011-03-16 | 1.5 | Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor |
| 6ROF | 2020-06-03 | 1.5 | Human Carbonic anhydrase II mutant T199V bound by 2-(cyclooctylamino)-3,5,6-trifluoro-4-[(2-hydroxyethyl)thio]benzenesulfonamide |
| 6YZM | 2020-10-28 | 1.5 | Carborane nido-pentyl-sulfonamide in complex with CA IX mimic |
| 3MMF | 2011-04-20 | 1.5 | Crystal structure of human carbonic anhydrase II in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor |
| 4Q99 | 2015-03-11 | 1.5 | Crystal structure of 2-mercapto-4-methylphenol bound to human carbonic anhydrase II |
| 6NJ2 | 2019-10-02 | 1.5 | thermostable carbonic anhydrase II variant with tetrazine 2.0 at site 186 |
| 3RG4 | 2012-02-22 | 1.5 | Crystal structure of the W5F mutant of human carbonic anhydrase II |
| 4GL1 | 2013-09-04 | 1.5 | Structure of H64A/N62L/N67L Human Carbonic Anhydrase II triple mutant |
| 6UZU | 2020-10-21 | 1.5 | Carbonic Anhydrase IX-mimic In Complex WITH U-CH3 |
| 3OIK | 2011-07-06 | 1.5 | Human Carbonic anhydrase II mutant A65S, N67Q (CA IX mimic) bound by 2-Ethylestradiol 3,17-O,O-bis-sulfamate |
| 3MHM | 2010-10-20 | 1.5 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-benzylamino-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide |
| 5E2S | 2016-01-20 | 1.5 | Crystal structure of human carbonic anhydrase II in complex with the 4-(2-iso-propylphenyl)benzenesulfonamide inhibitor |
| 4JSA | 2013-06-19 | 1.5 | Benzenesulfonamide complexed with hCAII H94D |
| 3P5L | 2011-10-19 | 1.5 | Human Carbonic Anhydrase complexed with sodium 4-cyano-4-phenylpiperidine-1-carbodithioate |
| 5THJ | 2017-04-26 | 1.5 | Crystal Structure of 2-hydroxycyclohepta-2,4,6-trien-1-one bound to human carbonic anhydrase 2 |
| 7JO1 | 2020-11-04 | 1.5 | Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)butyramide |
| 6YQT | 2020-07-01 | 1.5 | CRYSTAL STRUCTURE OF HUMAN CA II IN COMPLEX WITH A SULFONAMIDE DERIVATIVE OF 2-MERCAPTOBENZOXAZOLE |
| 5DSQ | 2016-05-04 | 1.5 | Structure of CO2 released apo-form of human carbonic anhydrase II with 3 min warming |
| 6C7X | 2018-05-23 | 1.5 | Carbonic anhydrase 2 in complex with 2-chloro-5'-O-sulfamoyladenosine |
| 3RLD | 2012-02-08 | 1.5 | Crystal structure of the Y7I mutant of human carbonic anhydrase II |
| 4JSS | 2013-06-19 | 1.5 | Human carbonic anhydrase II H94D bound to a bidentate inhibitor |
| 6OUK | 2020-05-06 | 1.5 | Carbonic Anhydrase II complexed with benzene sulfonamide MB10-580B |
| 6RMY | 2020-06-03 | 1.5 | Human Carbonic anhydrase II mutant T199V bound by 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide |
| 3RZ1 | 2011-08-10 | 1.51 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 4YGL | 2015-03-25 | 1.51 | NaClO4--Interactions between Hofmeister Anions and the Binding Pocket of a Protein |
| 5JN7 | 2017-05-03 | 1.52 | Carbonic Anhydrase II In Complex WITH U-CH3 |
| 4QK2 | 2015-03-04 | 1.52 | Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - E234P |
| 4MDL | 2014-01-01 | 1.52 | Meta Carborane Carbonic Anhydrase Inhibitor |
| 6OUI | 2020-05-06 | 1.53 | Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB11-710A |
| 4RN4 | 2015-01-28 | 1.53 | Human Carbonic anhydrases II in complex with a acetazolamide derivative comprising one hydrophobic and one hydrophilic tail moiety |
| 5WGP | 2018-02-07 | 1.53 | Human Carbonic Anhydrase IX-mimic complexed with AceK |
| 5TY9 | 2017-08-30 | 1.53 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 4Q90 | 2015-03-11 | 1.54 | Crystal structure of 4-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 5U0G | 2017-08-30 | 1.54 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 2CBA | 1993-10-31 | 1.54 | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES |
| 5EZT | 2016-07-20 | 1.54 | Peracetylated Bovine Carbonic Anhydrase II |
| 3OYS | 2011-08-10 | 1.54 | Human Carbonic Anhydrase II complexed with 2-{[4-AMINO-3-(3-HYDROXYPROP-1-YN-1-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL]METHYL}-5-METHYL-3-(2-METHYLPHENYL)QUINAZOLIN-4(3H)-ONE |
| 4N16 | 2014-06-18 | 1.54 | Structure of cholate bound to human carbonic anhydrase II |
| 4JS6 | 2013-06-19 | 1.55 | Crystal structure of inhibitor-free hCAII H94D |
| 3U3A | 2012-10-10 | 1.55 | structure of Human Carbonic Anhydrase II V143I |
| 5AMG | 2015-04-08 | 1.55 | Three dimensional structure of human carbonic anhydrase II in complex with 2-(Pentylsulfamoyl)-4-sulfamoylbenzoic acid |
| 4Q9Y | 2015-03-11 | 1.55 | Crystal structure of 3-methylthiophenol bound to human carbonic anhydrase II |
| 4E3G | 2012-06-27 | 1.55 | Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors |
| 4MDM | 2014-01-01 | 1.55 | Nido-Carborane Carbonic Anhydrase Inhibitor |
| 2HNC | 2006-12-19 | 1.55 | Crystal structure of the human carbonic anhydrase II in complex with the 5-amino-1,3,4-thiadiazole-2-sulfonamide inhibitor. |
| 4Q81 | 2015-03-11 | 1.55 | Crystal structure of 1-hydroxy-4,6-dimethylpyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 4Q87 | 2015-03-11 | 1.55 | Crystal structure of 1-hydroxy-4-(trifluoromethyl)pyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 1ZFQ | 2006-05-23 | 1.55 | carbonic anhydrase II in complex with ethoxzolamidphenole as sulfonamide inhibitor |
| 5SZ1 | 2016-12-21 | 1.55 | Carbonic anhydrase II in complex with 4-(2-methylphenyl)-benzenesulfonamide |
| 4KUW | 2014-06-25 | 1.55 | Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(4-fluorophenylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor |
| 3IBL | 2009-09-22 | 1.55 | The crystal structure of the human carbonic anhydrase II in complex with an aliphatic bis-sulfamate inhibitor |
| 6YJ3 | 2020-09-09 | 1.55 | Metala-Carborane di-propyl-sulfonamide |
| 5CLU | 2015-11-11 | 1.55 | THE CRYSTAL STRUCTURE OF THE COMPLEX of HCAII WITH A SACCHARINE DERIVATIVE |
| 6R6J | 2020-04-08 | 1.55 | Crystal structure of human carbonic anhydrase isozyme II with 2-(benzenesulfonyl)-4-chloro-N-(2-hydroxyethyl)-5-sulfamoyl-benzamide |
| 2HL4 | 2007-05-22 | 1.55 | Crystal structure analysis of human carbonic anhydrase II in complex with a benzenesulfonamide derivative |
| 4Q83 | 2015-03-11 | 1.55 | Crystal structure of 1-hydroxy-3-(trifluoromethyl)pyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 4KV0 | 2014-06-25 | 1.55 | Crystal structure of human carbonic anhydrase II in complex with the 5-(3-tosylureido)pyridine-2-sulfonamide inhibitor |
| 6H34 | 2018-12-19 | 1.55 | The crystal structure of human carbonic anhydrase II in complex with 4-[(4-fluorophenyl)methyl]-1-piperazinyl]benzenesulfonamide. |
| 4Q8X | 2015-03-11 | 1.55 | Crystal structure of 1-hydroxy-5-(trifluoromethyl)pyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 5G0B | 2016-05-25 | 1.55 | An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C |
| 6CJV | 2018-08-08 | 1.55 | Carbonic anhydrase IX-mimic in complex with sucralose |
| 6GOT | 2018-10-03 | 1.56 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(phenethylthio)benzenesulfonamide |
| 6OUM | 2020-05-06 | 1.56 | Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB10-580B |
| 3V3G | 2012-06-20 | 1.56 | Kinetic and structural studies of thermostabilized mutants of HCA II. |
| 1ZFK | 2006-05-23 | 1.56 | carbonic anhydrase II in complex with N-4-sulfonamidphenyl-N'-4-methylbenzosulfonylurease as sulfonamide inhibitor |
| 2VVA | 2009-07-14 | 1.56 | Human carbonic anhydrase in complex with CO2 |
| 5WLT | 2018-08-01 | 1.57 | Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide |
| 5A6H | 2016-05-25 | 1.57 | Synthesis, carbonic anhydrase inhibition and protein X-ray structure of the unusual natural product primary sulfonamide Psammaplin C |
| 6RVK | 2019-08-28 | 1.58 | Crystal structure of hCA II in complex with Urea, N-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-N'-(phenylmethyl)- |
| 6H33 | 2018-12-19 | 1.58 | The crystal structure of human carbonic anhydrase II in complex with 4-(4-phenyl)-4-hydroxy-1-piperidine-1-carbonyl)benzenesulfonamide. |
| 5FNK | 2016-03-02 | 1.59 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 5FNL | 2016-09-28 | 1.59 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 5U0D | 2017-08-30 | 1.59 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 5FNM | 2016-03-02 | 1.59 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 4K13 | 2014-04-09 | 1.6 | Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with dorzolamide |
| 3S76 | 2011-10-19 | 1.6 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 3TVO | 2012-08-08 | 1.6 | Human Carbonic Anhydrase II Proton Transfer Double Mutant |
| 2FMZ | 2006-05-23 | 1.6 | Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine, structure with D-Phenylalanine. |
| 3DVD | 2008-11-11 | 1.6 | X-ray crystal structure of mutant N62D of human Carbonic Anhydrase II |
| 1CIL | 1994-01-31 | 1.6 | THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS |
| 1FR4 | 2001-01-17 | 1.6 | X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT |
| 6SYB | 2020-10-07 | 1.6 | Crystal structure of carbonic anhydrase 2 with (3aR,4S,9bS)-4-(2-chloro-4-hydroxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide |
| 2QOA | 2008-01-22 | 1.6 | Crystal structure of the complex of hcaii with an indane-sulfonamide inhibitor |
| 1G0F | 2000-10-18 | 1.6 | SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMAN CARBONIC ANHYDRASE II |
| 4ILX | 2013-02-13 | 1.6 | Structure of human carbonic anhydrase II in complex with an adamantyl sulfonamide inhibitor |
| 4ZX0 | 2015-10-28 | 1.6 | Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor |
| 6NJ6 | 2019-10-02 | 1.6 | Thermostable variant of human carbonic anhydrase with tetrazine 2.0 at site 186 reacted with sTCO in crystallo |
| 5E2R | 2015-11-04 | 1.6 | The crystal structure of the human carbonic anhydrase II in complex with a 1,1'-biphenyl-4-sulfonamide inhibitor |
| 3S72 | 2011-10-19 | 1.6 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 4IDR | 2012-12-26 | 1.6 | Human Carbonic Anhydrase II Proton Transfer Double Mutant |
| 4LHI | 2014-07-02 | 1.6 | Crystal structure of human carbonic anhydrase isozyme II with 5-(phenylsulfonyl)thiophene-2-sulfonamide |
| 4ZWI | 2015-08-26 | 1.6 | Surface Lysine Acetylated Human Carbonic Anhydrase II in Complex with a Sulfamate-Based Inhibitor |
| 2POV | 2007-07-24 | 1.6 | The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-chloro-benzene-1,3-disulfonamide |
| 3DCC | 2009-03-03 | 1.6 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 3RYX | 2011-08-10 | 1.6 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 3M40 | 2010-10-20 | 1.6 | Crystal structure of human carbonic anhydrase isozyme II with 4-[N-(6-chloro-5-nitropyrimidin-4-yl)amino]benzenesulfonamide |
| 3OY0 | 2011-08-10 | 1.6 | Human Carbonic Anhydrase II complexed with 1-(4-(4-(2-(ISOPROPYLSULFONYL)PHENYLAMINO)-1H-PYRROLO[2,3-B]PYRIDIN-6-YLAMINO)-3-METHOXYPHENYL)PIPERIDIN-4-OL |
| 3N4B | 2011-03-09 | 1.6 | Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor |
| 5BRV | 2015-06-24 | 1.6 | Catalytic Improvement of an Artificial Metalloenzyme by Computational Design |
| 6RMX | 2020-06-03 | 1.6 | Human Carbonic anhydrase II mutant T199V bound by 2-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-3,5,6-trifluoro-4-[(2-hydroxyethyl)thio]benzenesulfonamide |
| 4HT0 | 2013-04-10 | 1.6 | Crystal structure of human carbonic anhydrase isozyme II with the inhibitor. |
| 3R16 | 2011-05-25 | 1.6 | Human CAII bound to N-(4-sulfamoylphenyl)-2-(thiophen-2-yl) acetamide |
| 3P3J | 2011-09-21 | 1.6 | Human carbonic anhydrase II in complex with p-(5-ruthenocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide |
| 5JN3 | 2017-05-03 | 1.6 | Carbonic Anhydrase IX-mimic IN Complex WITH U-F |
| 4QK1 | 2015-03-04 | 1.6 | Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - K170P |
| 5TY1 | 2017-10-04 | 1.6 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 2EU3 | 2006-07-11 | 1.6 | Human Carbonic anhydrase II in complex with novel inhibitors |
| 4IWZ | 2013-12-11 | 1.6 | structure of hCAII in complex with an acetazolamide derivative |
| 3DC9 | 2009-03-03 | 1.6 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 2OSM | 2008-02-12 | 1.6 | Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study |
| 4E3D | 2012-06-27 | 1.6 | Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors |
| 3DVC | 2008-11-11 | 1.6 | X-ray crystal structure of mutant N62T of human Carbonic Anhydrase II |
| 5SZ4 | 2016-12-21 | 1.6 | Carbonic anhydrase IX-mimic in complex with 4-(phenyl)-benzenesulfonamide |
| 3DAZ | 2009-03-03 | 1.6 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 2FMG | 2006-05-23 | 1.6 | Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine and crystallographic analysis of their adducts with isozyme II: sterospecific recognition within the active site of an enzyme and its consequences for the drug design, structure with L-phenylalanine |
| 3U47 | 2012-10-10 | 1.6 | Human Carbonic Anhydrase II V143L |
| 5W8B | 2018-05-30 | 1.6 | Carbonic anhydrase II in complex with activating histamine pyridinium derivative |
| 6E8X | 2019-03-27 | 1.6 | CA IX mimic Complexed with Steroidal Sulfamate Compound STX 140 |
| 2POU | 2007-07-24 | 1.6 | The crystal structure of the human carbonic anhydrase II in complex with 4,5-dichloro-benzene-1,3-disulfonamide |
| 2OSF | 2008-05-27 | 1.6 | Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study |
| 4Q7V | 2015-03-11 | 1.6 | Crystal structure of 1-hydroxy-5-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 5BRU | 2015-06-24 | 1.6 | Catalytic Improvement of an Artificial Metalloenzyme by Computational Design |
| 1G0E | 2000-10-18 | 1.6 | SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH 4-METHYLIMIDAZOLE |
| 5FNI | 2016-03-02 | 1.6 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 7JO0 | 2020-11-04 | 1.61 | Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)propionamide |
| 4ZWZ | 2015-08-05 | 1.62 | Engineered Carbonic Anhydrase IX mimic in complex with a glucosyl sulfamate inhibitor |
| 6B5A | 2018-09-05 | 1.62 | Carbonic anhydrase IX-mimic in complex with nitrogenous base-bearing benezenesulfonamide |
| 4CNV | 2015-02-04 | 1.62 | Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture |
| 3V3J | 2012-06-20 | 1.63 | Kinetic and structural studies of thermostabilized mutants of HCA II. |
| 4RFD | 2015-04-15 | 1.63 | Human carbonic anhydrase II in complex with 4-(4-sulfamoyl-phenoxy)-butylammonium |
| 4RIV | 2015-02-04 | 1.63 | A Carbonic Anhydrase IX Mimic in Complex with Saccharin |
| 5SZ0 | 2016-12-21 | 1.63 | Carbonic anhydrase II in complex with 4-(phenyl)-benzenesulfonamide |
| 4RUZ | 2015-04-22 | 1.63 | Crystal structure of human Carbonic Anhydrase II in complex with 4-ethoxybenzenesulfonamide |
| 6EEA | 2018-11-28 | 1.63 | Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. |
| 5SZ2 | 2016-12-21 | 1.63 | Carbonic anhydrase II in complex with 4-(3-formylphenyl)-benzenesulfonamide |
| 4N0X | 2014-01-29 | 1.63 | Room temperature crystal structure of human carbonic anhydrase II in complex with thiophene-2-sulfonamide |
| 6EEH | 2018-11-28 | 1.63 | Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. |
| 1TH9 | 2005-01-25 | 1.63 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 4L5V | 2014-04-30 | 1.63 | The structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II |
| 4R5A | 2014-10-15 | 1.64 | A Carbonic Anhydrase IX Mimic in Complex with a Carbohydrate-Based Sulfamate |
| 6B59 | 2018-09-05 | 1.64 | Carbonic anhydrase II in complex with nitrogenous base-bearing benezenesulfonamide |
| 4RFC | 2015-04-15 | 1.64 | Human carbonic anhydrase II in complex with tert-butyl 4-(4-sulfamoylphenoxy)butylcarbamate |
| 2X7S | 2010-03-31 | 1.64 | Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors. |
| 3KOI | 2010-08-25 | 1.64 | Crystal structure of cobalt (III) human carbonic anhydrase II at pH 6.0 |
| 2NWY | 2007-04-24 | 1.65 | Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II |
| 3N2P | 2011-03-09 | 1.65 | Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor |
| 4MLX | 2014-07-02 | 1.65 | Structure of a bidentate 3-hydroxy-4H-pyran-4-thione ligand bound to hCAII |
| 3D9Z | 2009-03-03 | 1.65 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 3T5Z | 2012-06-20 | 1.65 | Crystal structure of the human carbonic anhydrase II in complex with N-methoxy-benzenesulfonamide |
| 3RZ5 | 2011-08-10 | 1.65 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 4Q7P | 2015-03-11 | 1.65 | Crystal Structure of 1-hydroxy-3-methylpyridine-2(1H)-thione bound to hCAII |
| 3M2N | 2011-02-16 | 1.65 | Crystal structure of human carbonic anhydrase isozyme II with 4-{2-[N-(6-chloro-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide |
| 1ZGE | 2006-05-23 | 1.65 | carbonic anhydrase II in complex with p-Sulfonamido-o,o'-dichloroaniline as sulfonamide inhibitor |
| 4KUY | 2014-06-25 | 1.65 | Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(o-tolylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor |
| 3MNH | 2010-07-14 | 1.65 | Human Carbonic Anhydrase II Mutant K170A |
| 6EQU | 2017-12-13 | 1.65 | X-Ray crystal structure of the human carbonic anhydrase II adduct with a membrane-impermeant inhibitor |
| 4R59 | 2014-10-15 | 1.65 | A Carbonic Anhydrase IX Mimic in Complex with a Carbohydrate-Based Sulfamate |
| 3IGP | 2010-03-09 | 1.65 | Structure of inhibitor binding to Carbonic Anhydrase II |
| 4RIU | 2015-02-04 | 1.65 | A Carbonic Anhydrase IX Mimic in Complex with a Saccharin-Based Inhibitor |
| 6YZV | 2020-10-28 | 1.65 | Closo-carborane ethyl-sulfonamide in complex with CA II |
| 3SBH | 2012-04-11 | 1.65 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide |
| 4M2W | 2013-11-06 | 1.66 | Genetically engineered Carbonic Anhydrase IX in complex with Dorzolamide |
| 1Z9Y | 2006-05-23 | 1.66 | carbonic anhydrase II in complex with furosemide as sulfonamide inhibitor |
| 5FLO | 2016-03-02 | 1.66 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 2VVB | 2009-07-14 | 1.66 | Human carbonic anhydrase II in complex with bicarbonate |
| 5FNH | 2016-03-02 | 1.66 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 6UFB | 2020-08-05 | 1.67 | Carbonic anhydrase 2 with inhibitor (2Z)-2-benzylidene-3-oxo-N-(4-sulfamoylphenyl)butanamide (11a/D1) |
| 5FLS | 2016-03-02 | 1.67 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 5FLT | 2016-03-02 | 1.67 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 2CBD | 1993-10-31 | 1.67 | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES |
| 2CBB | 1993-10-31 | 1.67 | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES |
| 5FNJ | 2016-03-02 | 1.67 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 6RM1 | 2020-04-15 | 1.68 | Human Carbonic Anhydrase II in complex with fragment. |
| 5FLR | 2016-03-02 | 1.68 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 3M3X | 2010-10-20 | 1.68 | Crystal structure of human carbonic anhydrase isozyme II with 4-{2-[N-(6-methoxy-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide |
| 3M1Q | 2011-05-25 | 1.69 | Carbonic Anhydrase II mutant W5C-H64C with opened disulfide bond |
| 5SZ3 | 2016-12-21 | 1.69 | Carbonic anhydrase II in complex with 4-(3-quinolinyl)-benzenesulfonamide |
| 3HKQ | 2009-10-13 | 1.7 | Human carbonic anhydrase II in complex with 1-S-D-Galactopyranosylsulfonamide |
| 3DVB | 2008-11-11 | 1.7 | X-ray crystal structure of mutant N62V human Carbonic Anhydrase II |
| 3CYU | 2008-05-27 | 1.7 | Human Carbonic Anhydrase II complexed with Cryptophane biosensor and xenon |
| 5J8Z | 2016-06-29 | 1.7 | Human carbonic anhydrase II in complex with ligand |
| 3RZ8 | 2011-08-10 | 1.7 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 3MHI | 2010-10-20 | 1.7 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[(5-nitro-6-oxo-1,6-dihydro-4-pyrimidinyl)amino]methyl}benzenesulfonamide |
| 4L5W | 2014-04-30 | 1.7 | Structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II |
| 1YO1 | 2005-09-20 | 1.7 | Proton Transfer from His200 in Human Carbonic Anhydrase II |
| 5N0D | 2017-05-10 | 1.7 | Crystal structure of human carbonic anhydrase II in complex with (R)-4-(6,7-dihydroxy-1-phenyl-3,4-tetrahydroisoquinoline-1H-2-carbonyl)benzenesulfonamide. |
| 2NXR | 2007-04-24 | 1.7 | Structural effects of hydrophobic mutations on the active site of human carbonic anhydrase II |
| 3M5E | 2010-10-20 | 1.7 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-chloro-5-formyl-2-methylthiopyrimidin-4-yl)amino]methyl}benzenesulfonamide |
| 3U45 | 2012-10-10 | 1.7 | Human Carbonic Anhydrase II V143A |
| 6YO4 | 2020-08-19 | 1.7 | Para-Carborane propyl-sulfonamide in complex with CA IX mimic |
| 3R17 | 2011-05-25 | 1.7 | hCarbonic anhydrase II bound to N-(2-fluoro.4-sulfamoylphenyl)-2-(thiophen-2-yl) acetamide |
| 3MHC | 2010-07-21 | 1.7 | Crystal structure of human cabonic anhydrase II in adduct with an adamantyl analogue of acetazolamide in a novel hydrophobic binding pocket |
| 4HEW | 2013-10-23 | 1.7 | Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure |
| 3C7P | 2009-01-13 | 1.7 | Crystal structure of human carbonic anhydrase II in complex with STX237 |
| 1ZH9 | 2006-05-23 | 1.7 | carbonic anhydrase II in complex with N-4-Methyl-1-piperazinyl-N'-(p-sulfonamide)phenylthiourea as sulfonamide inhibitor |
| 6RW1 | 2019-08-28 | 1.7 | Crystal structure of hCA II in complex with Urea, N-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-N'-(phenylmethyl)- |
| 3D8W | 2009-03-03 | 1.7 | Use of a carbonic Anhydrase II, IX Active-site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 5L6K | 2017-03-01 | 1.7 | Crystal Structure of Human Carbonic Anhydrase II in Complex with a Quinoline Oligoamide Foldamer |
| 3M2Z | 2011-07-06 | 1.7 | Fragment tethered to Carbonic Anhydrase II H64C mutant |
| 1CAM | 1993-10-31 | 1.7 | STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 3DBU | 2009-03-03 | 1.7 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 5NEE | 2017-12-06 | 1.7 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor 5-[2-(morpholine-4-carbonyl)1,3-oxazol-5-yl)]thiophene-2-sulfonammide |
| 3DV7 | 2008-11-11 | 1.7 | Role of Hydrophilic Residues in Proton Transfer During Catalysis by Human Carbonic Anhydrase II (N62A) |
| 4ZWX | 2015-10-28 | 1.7 | Engineered Carbonic Anhydrase IX mimic in complex with glucosyl sulfamate inhibitor |
| 4E5Q | 2013-03-27 | 1.7 | Human Carbonic Anhydrase II in complex with cyanate |
| 3DC3 | 2009-03-03 | 1.7 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 1MUA | 1993-10-31 | 1.7 | STRUCTURE AND ENERGETICS OF A NON-PROLINE CIS-PEPTIDYL LINKAGE IN AN ENGINEERED PROTEIN |
| 6MBV | 2019-03-13 | 1.7 | Carbonic Anhydrase II in complex with Nicotinic Acid |
| 5DOG | 2016-09-28 | 1.7 | Crystal structure of human carbonic anhydrase isozyme II with 2-(Benzylamino)-3,5,6-trifluoro-4-[(2-phenylethyl)thio]benzene- sulfonamide |
| 2Q1B | 2007-09-04 | 1.7 | Carbonic Anhydrase II in Complex with Saccharin |
| 5LMD | 2016-10-19 | 1.7 | The crystal structure of hCA II in complex with a benzoxaborole inhibitor |
| 5FLQ | 2016-03-02 | 1.7 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 3V2J | 2012-12-26 | 1.7 | Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II |
| 4K1Q | 2014-04-09 | 1.7 | Structure of hCAIX mimic (hCAII with 5 mutations in active site) |
| 4ITP | 2014-01-01 | 1.7 | Structure of human carbonic anhydrase II bound to a benzene sulfonamide |
| 2NWO | 2007-04-24 | 1.7 | Structural and kinetic effect of hydrophobic mutations in the active site of human carbonic anhydrase II |
| 5FLP | 2016-03-02 | 1.71 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 2F14 | 2006-10-24 | 1.71 | Tne Crystal Structure of the Human Carbonic Anhydrase II in Complex with a Fluorescent Inhibitor |
| 6RVL | 2019-08-28 | 1.72 | Crystal structure of hCA II with Urea, N-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-?N'-phenyl- |
| 6EEO | 2018-11-28 | 1.72 | Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. |
| 4M2V | 2013-11-06 | 1.72 | Genetically engineered Carbonic Anhydrase IX in complex with Brinzolamide |
| 3V3I | 2012-06-20 | 1.73 | Kinetic and structural studies of thermostabilized mutants of HCA II. |
| 4PYY | 2015-01-28 | 1.75 | Crystal structure of human carbonic anhydrase isozyme II with inhibitor |
| 3MNJ | 2010-07-14 | 1.75 | Human Carbonic Anhydrase II Mutant K170E |
| 1LG5 | 2002-07-24 | 1.75 | Crystal Structure Analysis of the HCA II Mutant T199P in complex with beta-mercaptoethanol |
| 3MNI | 2010-07-14 | 1.75 | Human Carbonic Anhydrase II Mutant K170D |
| 3SAP | 2012-04-11 | 1.75 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[(5-butyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide |
| 2POW | 2007-07-24 | 1.75 | The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide |
| 4QJM | 2015-04-15 | 1.75 | Crystal structure of human carbonic anhydrase isozyme II with inhibitor |
| 5N0E | 2017-05-10 | 1.75 | Crystal structure of human carbonic anhydrase II in complex with (S)-4-(6,7-dihydroxy-1-phenyl-3,4-tetrahydroisoquinoline-1H-2-carbonyl)benzenesulfonamide. |
| 3T5U | 2012-06-20 | 1.75 | Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide |
| 3EFI | 2008-09-30 | 1.75 | Carbonic anhydrase activators: Kinetic and X-ray crystallographic study for the interaction of d- and l-tryptophan with the mammalian isoforms I-XIV |
| 3MNK | 2010-07-14 | 1.75 | Human Carbonic Anhydrase II Mutant K170H |
| 6T4P | 2020-10-14 | 1.75 | Human Carbonic anhydrase II bound by napthalene-1-sulfonamide |
| 1ZGF | 2006-05-23 | 1.75 | carbonic anhydrase II in complex with trichloromethiazide as sulfonamide inhibitor |
| 6SKV | 2020-08-26 | 1.75 | Crystal structure of bovine carbonic anhydrase II in complex with a benzenesulfonamide-based ligand (SH2) |
| 3S73 | 2011-12-21 | 1.75 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 6SKS | 2020-08-26 | 1.75 | Crystal structure of bovine carbonic anhydrase II in complex with a benzenesulfonamide-based ligand (SH1) |
| 5FDC | 2016-05-18 | 1.75 | Crystal structure of Human Carbonic Anhydrase II in complex with the anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog. |
| 1XQ0 | 2005-05-17 | 1.76 | Structure of human carbonic anhydrase II with 4-[(3-bromo-4-O-sulfamoylbenzyl)(4-cyanophenyl)amino]-4H-[1,2,4]-triazole |
| 4HBA | 2013-07-31 | 1.76 | Structural and Catalytic Characterization of a Thermal and Acid Stable Variant of Human Carbonic Anhydrase II Containing an Engineered Disulfide Bond |
| 6E92 | 2019-03-27 | 1.77 | CA IX mimic Complexed with Steroidal Sulfamate Compound STX 2845 |
| 4K0T | 2014-04-09 | 1.78 | Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with chlorzolamide |
| 5SZ7 | 2016-12-21 | 1.78 | Carbonic anhydrase IX-mimic in complex with 4-(3-quinolinyl)-benzenesulfonamide |
| 6NLV | 2020-01-15 | 1.79 | Selective inhibition of carbonic anhydrase IX activity, using compound SLC-149, displays limited anticancer effects in breast cancer cell lines |
| 4PYX | 2015-01-28 | 1.8 | Crystal structure of human carbonic anhydrase isozyme II with inhibitor |
| 2FNM | 2006-11-28 | 1.8 | Activation of human carbonic anhdyrase II by exogenous proton donors |
| 2FNN | 2006-11-28 | 1.8 | Activation of human carbonic anhydrase II by exogenous proton donors |
| 1YO0 | 2005-09-20 | 1.8 | Proton Transfer from His200 in Human Carbonic Anhydrase II |
| 4K0S | 2014-04-09 | 1.8 | Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with acetazolamide |
| 1THK | 2005-01-25 | 1.8 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 4KNI | 2013-11-06 | 1.8 | Crystal structure of human carbonic anhydrase isozyme II with 2-Chloro-4-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide |
| 4QTL | 2015-04-15 | 1.8 | Crystal structure of human carbonic anhydrase isozyme II with inhibitor |
| 4Q49 | 2015-02-25 | 1.8 | Room temperature neutron crystal structure of apo human carbonic anhydrase at pH 7.5 |
| 1ZSC | 1996-07-11 | 1.8 | CARBONIC ANHYDRASE II MUTANT E117Q, HOLO FORM |
| 2NXS | 2007-04-24 | 1.8 | Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II |
| 2NWP | 2007-04-24 | 1.8 | Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II |
| 3NB5 | 2011-04-20 | 1.8 | Human carbonic anhydrase II in complex with 2-(3-chloro-4-hydroxyphenyl)-N-(4-sulfamoylphenethyl)acetamide |
| 1G52 | 2000-11-08 | 1.8 | CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 3ML2 | 2011-04-20 | 1.8 | Human carbonic anhydsase II in complex with an aryl sulfonamide inhibitor |
| 5GMN | 2017-05-24 | 1.8 | Crystal structure of human carbonic anhydrase II in complex with polmacoxib |
| 1YO2 | 2005-09-20 | 1.8 | Proton Transfer from His200 in Human Carbonic Anhydrase II |
| 3HKN | 2009-10-13 | 1.8 | Human carbonic anhydrase II in complex with (2,3,4,6-Tetra-O-acetyl-beta-D-galactopyranosyl) -(1-4)-1,2,3,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosylsulfonamide |
| 6QFU | 2019-04-17 | 1.8 | Human carbonic anhydrase II with bound IrCp* complex (cofactor 7) to generate an artificial transfer hydrogenase (ATHase) |
| 1CAI | 1993-10-31 | 1.8 | STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 6BCC | 2018-02-28 | 1.8 | Joint X-ray/neutron structure of human carbonic anhydrase II in complex with ethoxzolamide |
| 3T83 | 2011-10-19 | 1.8 | Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates |
| 1RAY | 1993-10-31 | 1.8 | THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE |
| 1TG3 | 2005-01-25 | 1.8 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 3CAJ | 2008-04-08 | 1.8 | Crystal structure of the human carbonic anhydrase II in complex with ethoxzolamide |
| 1CNJ | 1995-07-10 | 1.8 | X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE |
| 3PJJ | 2012-01-18 | 1.8 | Synthetic Dimer of Human Carbonic Anhydrase II |
| 2NWZ | 2007-04-24 | 1.8 | Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II |
| 2WD3 | 2010-02-23 | 1.8 | Highly Potent First Examples of Dual Aromatase-Steroid Sulfatase Inhibitors based on a Biphenyl Template |
| 3HKU | 2009-10-13 | 1.8 | Human carbonic anhydrase II in complex with topiramate |
| 1I9Q | 2001-03-28 | 1.8 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(3,4,5-TRIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 4Q7S | 2015-03-11 | 1.8 | Crystal Structure of 1-hydroxy-4-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 5EOI | 2016-11-23 | 1.8 | Crystal structure of copper bound human Carbonic anhydrase II |
| 3MNU | 2010-06-16 | 1.8 | Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron containing aromatic sulfamide with mammalian isoforms I-XV |
| 2FNK | 2006-11-28 | 1.8 | Activation of Human Carbonic Anhydrase II by exogenous proton donors |
| 4K0Z | 2014-04-09 | 1.8 | Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with methazolamide |
| 1CNI | 1995-07-10 | 1.8 | X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE |
| 3DCS | 2009-03-03 | 1.8 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 3RZ0 | 2011-08-10 | 1.8 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 2HD6 | 2006-10-03 | 1.8 | Crystal structure of the human carbonic anhydrase II in complex with a hypoxia-activatable sulfonamide. |
| 5O07 | 2017-08-02 | 1.8 | The crystal structure of the human carbonic anhydrase II in complex with a nitroimidazole sulfamate inhibitor |
| 4ZAO | 2015-10-14 | 1.8 | Genetically engineered Carbonic anhydrase IX |
| 1RZB | 1993-10-31 | 1.8 | X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES |
| 4XE1 | 2015-03-18 | 1.8 | Human carbonic anhydrase II in complex with 6-SULFAMOYL-SACCHARIN |
| 3RZ7 | 2011-08-10 | 1.8 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 3M1J | 2011-01-19 | 1.8 | The crystal structure of a NAMI A-Carbonic Anhydrase II adduct discloses the mode of action of this novel anticancer metallodrug |
| 6E91 | 2019-03-27 | 1.8 | CA IX mimic Complexed with Steroidal Sulfamate Compound STX 2484 |
| 3M67 | 2010-11-03 | 1.8 | Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-[(6,7-dihydro-1H-[1,4]dioxino[2,3-f]benzimidazol-2-ylsulfanyl)acetyl]benzenesulfonamide |
| 1XEG | 2005-09-27 | 1.81 | Crystal structure of human carbonic anhydrase II complexed with an acetate ion |
| 3FFP | 2009-08-18 | 1.81 | X ray structure of the complex between carbonic anhydrase II and LC inhibitors |
| 4BF6 | 2014-01-22 | 1.82 | Three dimensional structure of human carbonic anhydrase II in complex with 5-(1-(3-Cyanophenyl)-1H-1,2,3-triazol-4-yl)thiophene-2- sulfonamide |
| 2CBE | 1993-10-31 | 1.82 | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES |
| 1G45 | 2000-11-08 | 1.83 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE |
| 1G4J | 2000-11-08 | 1.84 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE |
| 1I9M | 2001-03-28 | 1.84 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4-DIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 1G46 | 2000-11-08 | 1.84 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 3BET | 2008-10-07 | 1.85 | Crystal structure of the human carbonic anhydrase II in complex with STX 641 at 1.85 angstroms resolution |
| 1H9N | 1997-09-17 | 1.85 | H119N CARBONIC ANHYDRASE II |
| 4FL7 | 2012-08-15 | 1.85 | The crystal structure of human carbonic anhydrase II in complex with N-(Hydroxy)-benzamide |
| 4MO8 | 2013-10-30 | 1.85 | The crystal structure of the human carbonic anhydrase II in complex with N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide |
| 5FDI | 2016-05-18 | 1.85 | Crystal structure of Human Carbonic Anhydrase II with the anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog. |
| 1BV3 | 1999-09-28 | 1.85 | HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH UREA |
| 3EFT | 2009-09-08 | 1.85 | Crystal structure of the complex between Carbonic Anhydrase II and a spin-labeled sulfonamide incorporating TEMPO moiety |
| 4PQ7 | 2014-10-08 | 1.85 | The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide inhibitor |
| 4PXX | 2015-06-10 | 1.85 | Crystal structure of a highly thermal stabilized variant of Human Carbonic Anhydrase II |
| 3V3H | 2012-06-20 | 1.85 | Kinetic and structural studies of thermostabilized mutants of HCA II. |
| 1I9O | 2001-03-28 | 1.86 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4-TRIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 3S77 | 2011-10-19 | 1.86 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 1G54 | 2000-11-08 | 1.86 | CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE |
| 1G3Z | 2000-11-08 | 1.86 | CARBONIC ANHYDRASE II (F131V) |
| 1G48 | 2000-11-08 | 1.86 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 1I9N | 2001-03-28 | 1.86 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,5-DIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 3M2X | 2011-05-25 | 1.87 | Carbonic Anhydrase II in complex with novel sulfonamide inhibitor |
| 2CBC | 1993-10-31 | 1.88 | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES |
| 6EDA | 2018-11-28 | 1.88 | Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. |
| 6EBE | 2018-11-28 | 1.88 | Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. |
| 1CAH | 1993-10-31 | 1.88 | STRUCTURE OF COBALT CARBONIC ANHYDRASE COMPLEXED WITH BICARBONATE |
| 3B4F | 2008-01-22 | 1.89 | Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies |
| 2X7T | 2010-03-31 | 1.89 | Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors. |
| 1RZE | 1993-10-31 | 1.9 | X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES |
| 3RG3 | 2012-02-22 | 1.9 | Crystal structure of the W5E mutant of human carbonic anhydrase II |
| 3F4X | 2009-03-17 | 1.9 | Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules make the difference |
| 3MHL | 2010-10-20 | 1.9 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-methoxy-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide |
| 2CA2 | 1990-01-15 | 1.9 | CRYSTALLOGRAPHIC STUDIES OF INHIBITOR BINDING SITES IN HUMAN CARBONIC ANHYDRASE II. A PENTACOORDINATED BINDING OF THE SCN-ION TO THE ZINC AT HIGH P*H |
| 1BIC | 1993-10-31 | 1.9 | CRYSTALLOGRAPHIC ANALYSIS OF THR-200-> HIS HUMAN CARBONIC ANHYDRASE II AND ITS COMPLEX WITH THE SUBSTRATE, HCO3- |
| 1CAO | 1994-01-31 | 1.9 | CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS |
| 5LLH | 2017-08-16 | 1.9 | Crystal structure of human carbonic anhydrase isozyme II with 4-(1,3-Benzothiazol-2-ylthio)-2,3,5,6-tetrafluorobenzenesulfonamide |
| 1RAZ | 1993-10-31 | 1.9 | THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE |
| 3BL0 | 2008-01-22 | 1.9 | Carbonic anhydrase inhibitors. Interaction of 2-N,N-Dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies |
| 5JMZ | 2017-05-03 | 1.9 | Carbonic Anhydrase IX-mimic IN Complex WITH U-NO2 |
| 2H4N | 1997-09-17 | 1.9 | H94N CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE |
| 1F2W | 2000-06-08 | 1.9 | THE MECHANISM OF CYANAMIDE HYDRATION CATALYZED BY CARBONIC ANHYDRASE II REVEALED BY CRYOGENIC X-RAY DIFFRACTION |
| 1CRA | 1994-01-31 | 1.9 | THE COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND THE AROMATIC INHIBITOR 1,2,4-TRIAZOLE |
| 3K7K | 2010-01-26 | 1.9 | Crystal structure of the complex between Carbonic Anhydrase II and anions |
| 1LGD | 2002-07-24 | 1.9 | Crystal Structure Analysis of HCA II Mutant T199P in Complex with Bicarbonate |
| 1YDB | 1995-02-14 | 1.9 | STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II |
| 1CAJ | 1993-10-31 | 1.9 | STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 1TG9 | 2005-01-25 | 1.9 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 6SKT | 2020-08-26 | 1.9 | Crystal structure of bovine carbonic anhydrase II in complex with a benzenesulfonamide-based ligand (SH0) |
| 1UGE | 1997-04-01 | 1.9 | HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY LEU (A65L) |
| 3DD8 | 2008-08-12 | 1.9 | Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD-486019 with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies |
| 6E8P | 2019-04-03 | 1.9 | CA IX mimic Complexed with Steroidal Sulfamate Compound STX 49 |
| 2Q1Q | 2007-09-11 | 1.9 | Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies |
| 1RZA | 1993-10-31 | 1.9 | X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES |
| 2HKK | 2007-05-22 | 1.9 | Carbonic anhydrase activators: Solution and X-ray crystallography for the interaction of andrenaline with various carbonic anhydrase isoforms |
| 1BCD | 1993-10-31 | 1.9 | X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND A NEW TOPICAL INHIBITOR, TRIFLUOROMETHANE SULPHONAMIDE |
| 1RZD | 1993-10-31 | 1.9 | X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES |
| 1CNX | 1995-11-14 | 1.9 | SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS |
| 1RZC | 1993-10-31 | 1.9 | X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES |
| 5A25 | 2015-05-20 | 1.9 | Rational engineering of a mesophilic carbonic anhydrase to an extreme halotolerant biocatalyst |
| 1CAK | 1993-10-31 | 1.9 | STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 2H15 | 2007-03-27 | 1.9 | Carbonic anhydrase inhibitors: Clashing with Ala65 as a means of designing isozyme-selective inhibitors that show low affinity for the ubiquitous isozyme II |
| 4JSW | 2013-06-19 | 1.9 | Human carbonic anhydrase II H94C |
| 4JSZ | 2013-06-19 | 1.9 | Benzenesulfonamide bound to hCAII H94C |
| 1CNG | 1995-07-10 | 1.9 | X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE |
| 1CAN | 1994-01-31 | 1.9 | CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS |
| 1CAZ | 1993-10-31 | 1.9 | WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE |
| 5LLE | 2017-08-16 | 1.9 | Crystal structure of human carbonic anhydrase isozyme II with 4-(1-Adamantylamino)-2,3,5,6-tetrafluorobenzenesulfonamide |
| 1I9P | 2001-03-28 | 1.92 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4,6-TRIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 1IF4 | 2001-05-02 | 1.93 | Carbonic Anhydrase II Complexed With 4-fluorobenzenesulfonamide |
| 1I8Z | 2001-03-28 | 1.93 | CARBONIC ANHYDRASE II COMPLEXED WITH AL-6629 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-METHOXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE |
| 1I9L | 2001-03-28 | 1.93 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(4-FLUOROPHENYL)METHYL]-BENZAMIDE |
| 3IBI | 2009-09-22 | 1.93 | The crystal structure of the human carbonic anhydrase II in complex with an aliphatic sulfamate inhibitor |
| 6H2Z | 2018-12-19 | 1.94 | The crystal structure of human carbonic anhydrase II in complex with 4-(4-phenylpiperidine-1-carbonyl)benzenesulfonamide. |
| 1IF8 | 2001-05-02 | 1.94 | Carbonic Anhydrase II Complexed With (S)-N-(3-Indol-1-yl-2-methyl-propyl)-4-sulfamoyl-benzamide |
| 1G53 | 2000-11-08 | 1.94 | CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 2Q38 | 2007-10-02 | 1.95 | Carbonic Anhydrase II in complex with Saccharin at 1.95 Angstrom |
| 3M5T | 2011-05-25 | 1.95 | Fragment tethered to Carbonic Anhydrase II H64C mutant |
| 1TTM | 2004-10-05 | 1.95 | Human carbonic anhydrase II complexed with 667-coumate |
| 4QSI | 2015-01-21 | 1.95 | Crystal structure of human carbonic anhydrase isozyme II with 5-{[(4-tert-buthyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}-2-chlorobenzenesulfonamide |
| 1V9E | 2004-02-10 | 1.95 | Crystal Structure Analysis of Bovine Carbonic Anhydrase II |
| 1YDC | 1995-02-14 | 1.95 | STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II |
| 1G4O | 2000-11-08 | 1.96 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-PHENYLMETHYLBENZAMIDE |
| 5L3O | 2017-03-01 | 1.98 | Crystal Structure of Human Carbonic Anhydrase II in Complex with a Quinoline Oligoamide Foldamer |
| 3K2F | 2009-11-17 | 1.98 | Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma |
| 3S78 | 2011-10-19 | 1.98 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 1IF7 | 2001-05-02 | 1.98 | Carbonic Anhydrase II Complexed With (R)-N-(3-Indol-1-yl-2-methyl-propyl)-4-sulfamoyl-benzamide |
| 5EIJ | 2016-11-09 | 1.99 | Carbonic Anhydrase II in complex with Sulfonamide Inhibitor |
| 4M2R | 2013-11-06 | 1.99 | Human Carbonic Anhydrase II in complex with Brinzolamide |
| 1ZE8 | 2005-10-18 | 2.0 | Carbonic anhydrase II in complex with a membrane-impermeant sulfonamide inhibitor |
| 4KNJ | 2013-11-06 | 2.0 | Crystal structure of human carbonic anhydrase isozyme II with 2-Chloro-4-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide |
| 3T84 | 2011-10-19 | 2.0 | Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates |
| 2ABE | 2005-10-25 | 2.0 | Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators |
| 2EZ7 | 2006-07-18 | 2.0 | Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII and XIV with L- and D-histidine and crystallographic analysis of their adducts with isoform II: engineering proton transfer processes within the active site of an enzyme |
| 1UGF | 1997-04-01 | 2.0 | HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY THR (A65T) |
| 4Y0J | 2015-04-22 | 2.0 | H/D exchanged human carbonic anhydrase II pH 6 room temperature neutron crystal structure. |
| 3P55 | 2011-10-12 | 2.0 | Human carbonic anhydrase II in complex with p-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide |
| 1HEB | 1992-10-15 | 2.0 | STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II |
| 1H4N | 1997-09-17 | 2.0 | H94N CARBONIC ANHYDRASE II COMPLEXED WITH TRIS |
| 1CA2 | 1990-01-15 | 2.0 | REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION |
| 1FQL | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT |
| 4M2U | 2013-11-06 | 2.0 | Carbonic Anhydrase II in complex with Dorzolamide |
| 6BBS | 2018-02-28 | 2.0 | Joint X-ray/neutron structure of human carbonic anhydrase II in complex with brinzolamide |
| 1ZSB | 1996-07-11 | 2.0 | CARBONIC ANHYDRASE II MUTANT E117Q, TRANSITION STATE ANALOGUE ACETAZOLAMIDE |
| 3P4V | 2011-04-20 | 2.0 | Human carbonic anhydrase II in complex with (+)-Xylariamide A |
| 1IF9 | 2001-05-02 | 2.0 | Carbonic Anhydrase II Complexed With N-[2-(1H-Indol-5-yl)-butyl]-4-sulfamoyl-benzamide |
| 3KWA | 2010-07-14 | 2.0 | Polyamines inhibit carbonic anhydrases |
| 1UGC | 1997-04-01 | 2.0 | HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY HIS (A65H) |
| 1HEC | 1992-10-15 | 2.0 | STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II |
| 3V3F | 2012-06-20 | 2.0 | Kinetic and structural studies of thermostabilized mutants of HCA II. |
| 1UGD | 1997-01-27 | 2.0 | HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY SER (A65S) |
| 4MLT | 2014-07-02 | 2.0 | Structure of a monodentate 3-hydroxy-4H-pyran-4-thione ligand bound to hCAII |
| 4G0C | 2012-09-19 | 2.0 | Neutron structure of acetazolamide-bound human carbonic anhydrase II reveal molecular details of drug binding. |
| 2GEH | 2006-06-20 | 2.0 | N-Hydroxyurea, a versatile zinc binding function in the design of metalloenzyme inhibitors |
| 1T9N | 2005-01-25 | 2.0 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 1TBT | 2005-01-25 | 2.0 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 1FSR | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT |
| 3T82 | 2011-10-19 | 2.0 | Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates |
| 1AM6 | 1998-06-24 | 2.0 | CARBONIC ANHYDRASE II INHIBITOR: ACETOHYDROXAMATE |
| 3IEO | 2010-01-26 | 2.0 | The coumarin-binding site in carbonic anhydrase: the antiepileptic lacosamide as an example |
| 1TB0 | 2005-01-25 | 2.0 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 1FQM | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT |
| 3CA2 | 1990-01-15 | 2.0 | CRYSTALLOGRAPHIC STUDIES OF INHIBITOR BINDING SITES IN HUMAN CARBONIC ANHYDRASE II. A PENTACOORDINATED BINDING OF THE SCN-ION TO THE ZINC AT HIGH P*H |
| 3NJ9 | 2011-06-22 | 2.0 | Crystal structure of carbonic anhydrase II in complex with a Nir inhibitor |
| 6OTI | 2020-05-06 | 2.0 | Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB9-561B |
| 1FSQ | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT |
| 1IF5 | 2001-05-02 | 2.0 | Carbonic Anhydrase II Complexed With 2,6-difluorobenzenesulfonamide |
| 1TEQ | 2005-01-25 | 2.0 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 5BNL | 2015-07-15 | 2.0 | Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins |
| 1FQN | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT |
| 1FSN | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT |
| 1HED | 1992-10-15 | 2.0 | STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II |
| 1I91 | 2001-03-28 | 2.0 | CARBONIC ANHYDRASE II COMPLEXED WITH AL-6619 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-HYDROXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE |
| 1HEA | 1992-10-15 | 2.0 | CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) (HCA II) (E.C.4.2.1.1) MUTANT WITH LEU 198 REPLACED BY ARG (L198R) |
| 1AVN | 1997-12-24 | 2.0 | HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH THE HISTAMINE ACTIVATOR |
| 3F8E | 2009-10-06 | 2.0 | Coumarins are a novel class of suicide carbonic anhydrase inhibitors |
| 1TEU | 2005-01-25 | 2.0 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 1CNW | 1995-11-14 | 2.0 | SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS |
| 3KKX | 2010-01-12 | 2.0 | Neutron structure of human carbonic anhydrase II |
| 1UGB | 1997-01-27 | 2.0 | HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY GLY (A65G) |
| 1TE3 | 2005-01-25 | 2.0 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 1UGA | 1997-01-27 | 2.0 | HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY PHE (A65F) |
| 1I90 | 2001-03-28 | 2.0 | CARBONIC ANHYDRASE II COMPLEXED WITH AL-8520 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 4-AMINO-3,4-DIHYDRO-2-(3-METHOXYPROPYL)-, 1,1-DIOXIDE, (R) |
| 1FQR | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT |
| 3TMJ | 2011-11-09 | 2.0 | Joint X-ray/neutron structure of human carbonic anhydrase II at pH 7.8 |
| 4Z1E | 2015-08-26 | 2.01 | Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV) |
| 1XPZ | 2005-05-17 | 2.02 | Structure of human carbonic anhydrase II with 4-[4-O-sulfamoylbenzyl)(4-cyanophenyl)amino]-4H-[1,2,4]-triazole |
| 4CNW | 2015-02-04 | 2.03 | Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture |
| 1G1D | 2000-11-08 | 2.04 | CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE |
| 1CNH | 1995-07-10 | 2.05 | X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE |
| 4L5U | 2014-04-30 | 2.05 | The structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II |
| 5FNG | 2016-03-02 | 2.05 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 6RVF | 2019-08-28 | 2.07 | Crystal structure of hCA II in complex with Urea, N-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-N'-phenyl |
| 1IF6 | 2001-05-02 | 2.09 | Carbonic Anhydrase II Complexed With 3,5-difluorobenzenesulfonamide |
| 2WEH | 2009-11-10 | 2.09 | Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors |
| 2HOC | 2006-10-10 | 2.1 | Crystal structure of the human carbonic anhydrase II in complex with the 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide inhibitor |
| 1YDA | 1995-02-14 | 2.1 | STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II |
| 1OKL | 1997-01-11 | 2.1 | CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKL INHIBITOR 5-DIMETHYLAMINO-NAPHTHALENE-1-SULFONAMIDE |
| 5CA2 | 1992-10-31 | 2.1 | CONFORMATIONAL MOBILITY OF HIS-64 IN THE THR-200 (RIGHT ARROW) SER MUTANT OF HUMAN CARBONIC ANHYDRASE II |
| 2O4Z | 2007-05-15 | 2.1 | Crystal structure of the Carbonic Anhydrase II complexed with hydroxysulfamide inhibitor |
| 1BN4 | 1999-05-18 | 2.1 | CARBONIC ANHYDRASE II INHIBITOR |
| 3HFP | 2010-05-19 | 2.1 | Crystal structure of teh complex between CA II and the activator MAI |
| 1BN1 | 1999-05-18 | 2.1 | CARBONIC ANHYDRASE II INHIBITOR |
| 1YDD | 1995-02-14 | 2.1 | STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II |
| 1CIN | 1994-01-31 | 2.1 | THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS |
| 3BL1 | 2008-07-01 | 2.1 | Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited old leads for new applications |
| 3NI5 | 2011-06-22 | 2.1 | Carbonic anhydrase inhibitor: C1 family |
| 1CAY | 1993-10-31 | 2.1 | WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE |
| 1DCB | 1993-07-15 | 2.1 | STRUCTURE OF AN ENGINEERED METAL BINDING SITE IN HUMAN CARBONIC ANHYDRASE II REVEALS THE ARCHITECTURE OF A REGULATORY CYSTEINE SWITCH |
| 3RGE | 2012-02-22 | 2.1 | Crystal structure of the W5H mutant of human carbonic anhydrase II |
| 1CIM | 1994-01-31 | 2.1 | THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS |
| 1EOU | 2002-02-13 | 2.1 | CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH AN ANTICONVULSANT SUGAR SULFAMATE |
| 4CA2 | 1992-10-31 | 2.1 | ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II |
| 2X7U | 2010-03-31 | 2.12 | Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors. |
| 5UMC | 2017-12-06 | 2.15 | Synthesis of novel seleno ureido containing compounds as SLC-0111 analogs. Investigations on carbonic anhydrases activity, glutathione peroxidase and X-ray crystallography |
| 4LP6 | 2013-10-23 | 2.15 | Crystal Structure of Human Carbonic Anhydrase II in complex with a quinoline oligoamide foldamer |
| 1BNT | 1999-06-15 | 2.15 | CARBONIC ANHYDRASE II INHIBITOR |
| 1BNU | 1999-06-15 | 2.15 | CARBONIC ANHYDRASE II INHIBITOR |
| 1CNK | 1995-07-10 | 2.15 | X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE |
| 1CAL | 1993-10-31 | 2.2 | STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 3P44 | 2011-10-12 | 2.2 | Human carbonic anhydrase II in complex with p-(4-ruthenocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide |
| 1CVD | 1994-12-20 | 2.2 | STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE |
| 1UGG | 1997-01-27 | 2.2 | HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY SER (A65S)-ORTHORHOMBIC FORM |
| 1CNC | 1994-10-15 | 2.2 | COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES |
| 1H9Q | 1997-09-17 | 2.2 | H119Q CARBONIC ANHYDRASE II |
| 1BN3 | 1999-05-18 | 2.2 | CARBONIC ANHYDRASE II INHIBITOR |
| 1OKM | 1997-01-11 | 2.2 | CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKM INHIBITOR 4-SULFONAMIDE-[1-(4-AMINOBUTANE)]BENZAMIDE |
| 3IBN | 2009-09-22 | 2.2 | The crystal structure of the human carbonic anhydrase II in complex with an aliphatic bis-sulfamate inhibitor |
| 1CCT | 1995-02-07 | 2.2 | STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY |
| 5CAC | 1994-01-31 | 2.2 | REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION |
| 4CAC | 1994-01-31 | 2.2 | REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION |
| 5L70 | 2017-06-21 | 2.2 | CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER |
| 1LG6 | 2002-07-24 | 2.2 | Crystal Structure Analysis of HCA II Mutant T199P in Complex with Thiocyanate |
| 1XEV | 2005-09-20 | 2.2 | Crystal structure of human carbonic anhydrase II in a new crystal form |
| 1DCA | 1993-07-15 | 2.2 | STRUCTURE OF AN ENGINEERED METAL BINDING SITE IN HUMAN CARBONIC ANHYDRASE II REVEALS THE ARCHITECTURE OF A REGULATORY CYSTEINE SWITCH |
| 6ECZ | 2018-11-28 | 2.21 | Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. |
| 6Q3O | 2019-12-25 | 2.23 | PROTEIN-AROMATIC FOLDAMER COMPLEX CRYSTAL STRUCTURE |
| 1CCU | 1995-02-07 | 2.25 | STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY |
| 1A42 | 1999-03-23 | 2.25 | HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH BRINZOLAMIDE |
| 1CVF | 1994-11-30 | 2.25 | STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE |
| 1CVA | 1993-10-31 | 2.25 | STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 1CVE | 1994-11-30 | 2.25 | STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE |
| 1KWR | 2003-01-07 | 2.25 | HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH INHIBITOR 0134-36 |
| 1BNW | 1999-06-15 | 2.25 | CARBONIC ANHYDRASE II INHIBITOR |
| 4CNR | 2015-02-04 | 2.29 | Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture |
| 1HVA | 1993-10-31 | 2.3 | ENGINEERING THE ZINC BINDING SITE OF HUMAN CARBONIC ANHYDRASE II: STRUCTURE OF THE HIS-94-> CYS APOENZYME IN A NEW CRYSTALLINE FORM |
| 1CNY | 1995-11-14 | 2.3 | SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS |
| 1LZV | 2002-10-23 | 2.3 | Site-Specific Mutant (Tyr7 replaced with His) of Human Carbonic Anhydrase II |
| 1CA3 | 1992-10-15 | 2.3 | UNEXPECTED PH-DEPENDENT CONFORMATION OF HIS-64, THE PROTON SHUTTLE OF CARBONIC ANHYDRASE II. |
| 1CVC | 1994-01-31 | 2.3 | REDESIGNING THE ZINC BINDING SITE OF HUMAN CARBONIC ANHYDRASE II: STRUCTURE OF A HIS2ASP-ZN2+ METAL COORDINATION POLYHEDRON |
| 1CVH | 1995-02-07 | 2.3 | STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE |
| 1BNN | 1999-05-18 | 2.3 | CARBONIC ANHYDRASE II INHIBITOR |
| 1HCA | 1992-10-15 | 2.3 | UNEXPECTED PH-DEPENDENT CONFORMATION OF HIS-64, THE PROTON SHUTTLE OF CARBONIC ANHYDRASE II. |
| 1CCS | 1995-02-07 | 2.35 | STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY |
| 1CNB | 1994-10-15 | 2.35 | COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES |
| 3HKT | 2009-10-13 | 2.36 | Human carbonic anhydrase II in complex with alpha-D-Glucopyranosyl-(1->4)-1-thio-beta-D-glucopyranosylsulfonamide |
| 1BNQ | 1999-06-15 | 2.4 | CARBONIC ANHYDRASE II INHIBITOR |
| 7CA2 | 1992-07-15 | 2.4 | ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II |
| 1BNV | 1999-02-16 | 2.4 | CARBONIC ANHYDRASE II INHIBITOR |
| 1OKN | 1997-01-11 | 2.4 | CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKN INHIBITOR 4-SULFONAMIDE-[1-(4-N-(5-FLUORESCEIN THIOUREA)BUTANE)] |
| 12CA | 1992-10-15 | 2.4 | ALTERING THE MOUTH OF A HYDROPHOBIC POCKET. STRUCTURE AND KINETICS OF HUMAN CARBONIC ANHYDRASE II MUTANTS AT RESIDUE VAL-121 |
| 1CVB | 1993-10-31 | 2.4 | STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 3T85 | 2011-10-19 | 2.4 | Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates |
| 8CA2 | 1992-07-15 | 2.4 | ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II |
| 6YMB | 2020-08-12 | 2.5 | MicroED structure of human carbonic anhydrase II |
| 1ZSA | 1996-07-11 | 2.5 | CARBONIC ANHYDRASE II MUTANT E117Q, APO FORM |
| 6YMA | 2020-08-12 | 2.5 | MicroED structure of acetazolamide-bound human carbonic anhydrase II |
| 6CA2 | 1992-07-15 | 2.5 | ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II |
| 1KWQ | 2003-01-07 | 2.6 | HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH INHIBITOR 2000-07 |
| 1BNM | 1999-05-18 | 2.6 | CARBONIC ANHYDRASE II INHIBITOR |
| 5L6T | 2017-06-21 | 2.65 | CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER |
| 6Q9T | 2019-09-18 | 2.68 | Protein-aromatic foldamer complex crystal structure |
| 9CA2 | 1992-07-15 | 2.8 | ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II |
| 5L9E | 2017-06-21 | 2.9 | CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER |
| 6HZX | 2019-09-18 | 2.91 | Protein-aromatic foldamer complex crystal structure |
| 1V9I | 2004-02-10 | 2.95 | Crystal Structure Analysis of the site specific mutant (Q253C) of bovine carbonic anhydrase II |
| 1G6V | 2000-11-22 | 3.5 | Complex of the camelid heavy-chain antibody fragment CAB-CA05 with bovine carbonic anhydrase |