Thermal denaturation of erythrocyte carbonic anhydrase.
Abstract
An experimental study on the thermal behaviour of erythrocyte carbonic anhydrase was carried out with the main aim to estimate the thermodynamic parameters that control the stability of the enzyme. The effects of thermal denaturation on the catalytic properties of the enzyme were also investigated. Below 60 degrees C the enzyme was found to be very stable, whereas between 60 and 65 degrees C a drastic decrease in the biological activity was observed. From the obtained results some considerations were made about the stabilization of the active form of the protein. Study holds ProTherm entries: 10121, 10122 Extra Details: carbonic anhydrase; thermal denaturation; conformational stability;,bovine erythrocytes
Submission Details
ID: 35X8xCNJ4
Submitter: Connie Wang
Submission Date: April 24, 2018, 8:39 p.m.
Version: 1
Publication Details
Lavecchia R;Zugaro M,FEBS Lett. (1991) Thermal denaturation of erythrocyte carbonic anhydrase. PMID:1959599Additional Information
Study Summary
Structure view and single mutant data analysis
Study data
| Colors: | D | E | R | H | K | S | T | N | Q | A | V | I | L | M | F | Y | W | C | G | P |
|---|
Data Distribution
Studies with similar sequences (approximate matches)
Correlation with other assays (exact sequence matches)
Relevant PDB Entries
| Structure ID | Release Date | Resolution | Structure Title |
|---|---|---|---|
| 6QEB | 2019-02-06 | Assessment of a large enzyme-drug complex by proton-detected solid-state NMR without deuteration | |
| 6GCY | 2019-02-06 | Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (saccharin-sugar conjugate complex) | |
| 6FJJ | 2019-02-06 | Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (saccharin). | |
| 6HD2 | 2019-08-28 | Active-site conformational dynamics of carbonic anhydrase II under native conditions: An NMR perspective | |
| 6BC9 | 2018-02-28 | Joint X-ray/neutron structure of human carbonic anhydrase II in complex with dorzolamide | |
| 5C8I | 2016-07-20 | Joint X-ray/neutron structure of Human Carbonic Anhydrase II in complex with Methazolamide | |
| 6FJI | 2019-02-06 | Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (apo). | |
| 3K34 | 2010-05-12 | 0.9 | Human carbonic anhydrase II with a sulfonamide inhibitor |
| 6B00 | 2017-12-13 | 0.9 | Thermostabilized mutant of human carbonic anhydrase II - A65T L100H K154N L224S L240P A248T |
| 5Y2S | 2018-02-14 | 0.9 | 7.0 atm CO2-pressurized human carbonic anhydrase II |
| 3KS3 | 2010-01-26 | 0.9 | High resolution structure of Human Carbonic Anhydrase II at 0.9 A |
| 3U7C | 2013-02-13 | 0.93 | crystal structure of the V143I mutant of human carbonic anhydrase II |
| 1LUG | 2003-09-09 | 0.95 | Full Matrix Error Analysis of Carbonic Anhydrase |
| 4YXI | 2016-02-03 | 0.96 | Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (2). |
| 4FRC | 2013-07-17 | 0.98 | Carbonic Anhydrase II in complex with N'-sulfamoylpyrrolidine-1-carboximidamide |
| 4FPT | 2013-07-03 | 0.98 | Carbonic Anhydrase II in complex with ethyl (2Z,4R)-2-(sulfamoylimino)-1,3-thiazolidine-4-carboxylate |
| 4FU5 | 2013-07-17 | 0.98 | Carbonic Anhydrase II in complex with N-[(2Z)-1,3-oxazolidin-2-ylidene]sulfuric diamide |
| 5OGO | 2018-08-01 | 0.99 | Crystal structure of chimeric carbonic anhydrase I with 3-(Benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide |
| 2FOU | 2006-04-04 | 0.99 | Human Carbonic Anhydrase II complexed with two-prong inhibitors |
| 4Q78 | 2015-03-18 | 1.0 | Structure-assisted design of carborane-based inhibitors of carbonic anhydrase |
| 5LJT | 2017-06-21 | 1.0 | Crystal structure of human carbonic anhydrase II in complex with the 4-((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)benzenesulfonamide inhibitor |
| 5Y2R | 2018-02-14 | 1.0 | 2.5 atm CO2-pressurized human carbonic anhydrase II |
| 4MTY | 2013-12-11 | 1.0 | Structure at 1A resolution of a helical aromatic foldamer-protein complex. |
| 4YX4 | 2016-02-03 | 1.01 | Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (1). |
| 6G3Q | 2018-11-28 | 1.01 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor famotidine |
| 6NJ3 | 2019-10-02 | 1.01 | Thermostable variant of human carbonic anhydrase with ordered tetrazine 2.0 at site 233 |
| 2NNO | 2007-05-08 | 1.01 | Structure of inhibitor binding to Carbonic Anhydrase II |
| 6HR3 | 2019-10-09 | 1.02 | Human Carbonic Anhydrase II in complex with 4-Propylbenzenesulfonamide |
| 5LL8 | 2017-08-16 | 1.03 | Human Carbonic Anhydrase II in complex with aliphatic Benzenesulfonamide inhibitor. |
| 2NNS | 2007-05-08 | 1.03 | Structure of inhibitor binding to Carbonic Anhydrase II |
| 3V7X | 2012-04-04 | 1.03 | Complex of human carbonic anhydrase II with N-[2-(3,4-dimethoxyphenyl)ethyl]-4-sulfamoylbenzamide |
| 6I0W | 2019-11-20 | 1.04 | Human Carbonic Anhydrase II in complex with 4-Methoxybenzenesulfonamide |
| 3VBD | 2012-04-04 | 1.05 | Complex of human carbonic anhydrase II with 4-(6-methoxy-3,4-dihydroisoquinolin-1-yl)benzenesulfonamide |
| 2ILI | 2007-06-05 | 1.05 | Refine atomic structure of human carbonic anhydrase II |
| 4FVN | 2013-07-17 | 1.05 | Carbonic Anhydrase II in complex with N-(tetrahydropyrimidin-2(1H)-ylidene)sulfuric diamide |
| 4FVO | 2013-07-03 | 1.05 | Carbonic Anhydrase II in complex with N-[(2E)-3,4-dihydroquinazolin-2(1H)-ylidene]sulfuric diamide |
| 5DOH | 2016-09-28 | 1.05 | Crystal structure of human carbonic anhydrase isozyme II with 2-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-3,5,6-trifluoro-4-[(2-hydroxyethyl)thio]benzenesulfonamide |
| 1MOO | 2002-09-18 | 1.05 | Site Specific Mutant (H64A) of Human Carbonic Anhydrase II at high resolution |
| 5LJQ | 2017-06-21 | 1.05 | Crystal structure of human carbonic anhydrase II in complex with the 4-(4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl)benzenesulfonamide inhibitor |
| 4YXO | 2016-02-03 | 1.06 | Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (3). |
| 4PZH | 2015-01-28 | 1.06 | Crystal structure of human carbonic anhydrase isozyme II with 2,3,5,6-tetrafluoro-4[(2-hydroxyethyl)sulfonyl]benzenesulfonamide |
| 4WW6 | 2015-07-01 | 1.06 | Crystal structure of human carbonic anhydrase isozyme II with 2,3,5,6-Tetrafluoro-4-(propylthio)benzenesulfonamide |
| 4Q08 | 2015-01-28 | 1.07 | Crystal structure of chimeric carbonic anhydrase XII with inhibitor |
| 4YYT | 2016-02-03 | 1.07 | Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (5). |
| 6I3E | 2019-11-20 | 1.07 | Human Carbonic Anhydrase II in complex with 4-Butylbenzenesulfonamide |
| 5M78 | 2017-12-20 | 1.08 | Human Carbonic Anhydrase II in complex with fragment-like inhibitor. |
| 4YXU | 2016-02-03 | 1.08 | Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (4). |
| 6I1U | 2019-11-20 | 1.08 | Human Carbonic Anhydrase II in complex with 4-Ethoxybenzenesulfonamide |
| 6GDC | 2019-05-01 | 1.08 | Human Carbonic Anhydrase II in complex with Benzenesulfonamide |
| 6GM9 | 2019-06-19 | 1.09 | Human Carbonic Anhydrase II in complex with 4-Methylbenzenesulfonamide |
| 5NXV | 2018-01-17 | 1.1 | Carbonic Anhydrase II Inhibitor RA8 |
| 2WEG | 2009-11-10 | 1.1 | Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors |
| 5NY1 | 2018-01-17 | 1.1 | Carbonic Anhydrase II Inhibitor RA10 |
| 3D93 | 2008-09-02 | 1.1 | Apo Human carbonic anhydrase II bound with substrate carbon dioxide |
| 3D92 | 2008-09-02 | 1.1 | Human carbonic anhydrase II bound with substrate carbon dioxide |
| 5OGP | 2018-08-01 | 1.1 | Metalacarborane inhibitors of Carbonic Anhydrase IX |
| 5NY6 | 2018-01-17 | 1.1 | Carbonic Anhydrase II Inhibitor RA12 |
| 2FOS | 2006-04-04 | 1.1 | Human Carbonic Anhydrase II complexed with two-prong inhibitors |
| 4WL4 | 2015-10-14 | 1.1 | Crystal structure of human carbonic anhydrase II in complex with the 6-hydroxy-chromene-2-thione inhibitor |
| 6HQX | 2019-10-09 | 1.1 | Human Carbonic Anhydrase II in complex with 4-Ethylbenzenesulfonamide |
| 3HS4 | 2009-12-08 | 1.1 | Human carbonic anhydrase II complexed with acetazolamide |
| 3SAX | 2012-04-11 | 1.1 | Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-{[(5-ethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide |
| 5DRS | 2016-09-28 | 1.1 | Crystal structure of human carbonic anhydraseisozyme II with 3-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide |
| 5LLC | 2017-08-16 | 1.1 | Crystal structure of human carbonic anhydrase isozyme II with 3-(Methylamino)-2,5,6-trifluoro-4-[(2-phenylethyl)sulfonyl]benzenesulfonamide |
| 5JGT | 2017-01-11 | 1.1 | Human carbonic anhydrase II (F131Y/L198A) complexed with 1,3-thiazole-2-sulfonamide |
| 5OGN | 2018-08-01 | 1.1 | Metalacarborane inhibitors of Carbonic Anhydrase IX |
| 4YGJ | 2015-03-25 | 1.1 | NaBr--Interactions between Hofmeister Anions and the Binding Pocket of a Protein |
| 2NNV | 2007-05-08 | 1.1 | Structure of inhibitor binding to Carbonic Anhydrase II |
| 5NXW | 2018-01-17 | 1.1 | Carbonic Anhydrase II Inhibitor RA9 |
| 5JGS | 2017-01-11 | 1.11 | Human carbonic anhydrase II (F131Y/L198A) complexed with benzo[d]thiazole-2-sulfonamide |
| 4Q6D | 2014-11-26 | 1.12 | Crystal structure of human carbonic anhydrase isozyme II with 4-[(Z)-azepan-1-yldiazenyl]benzenesulfonamide |
| 4Q6E | 2014-11-26 | 1.12 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[3-(3,5-Dimethyl-1H-pyrazol-1-yl)-3-oxopropyl]amino}benzene-1-sulfonamide |
| 6G6T | 2019-03-13 | 1.12 | Crystal structure of human carbonic anhydrase isozyme II with N-butyl-2,4-dichloro-5-sulfamoyl-benzamide |
| 5LL4 | 2017-08-16 | 1.12 | Crystal structure of human carbonic anhydrase isozyme II with 4-(1H-benzimidazol-1-ylacetyl)benzenesulfonamide |
| 5LLG | 2017-08-16 | 1.12 | Crystal structure of human carbonic anhydrase isozyme II with 4-Propylthiobenzenesulfonamide |
| 6HXD | 2019-10-30 | 1.12 | Human Carbonic Anhydrase II in complex with 4-Butylbenzenesulfonamide |
| 5EKJ | 2016-01-06 | 1.13 | Human Carbonic Anhydrase II complexed with a two-faced guest |
| 5JEH | 2017-01-11 | 1.13 | Human carbonic anhydrase II (L198A) complexed with benzo[d]thiazole-2-sulfonamide |
| 4RUY | 2015-04-22 | 1.14 | Crystal structure of human Carbonic Anhydrase II in complex with 4-propoxybenzenesulfonamide |
| 4RUX | 2015-04-22 | 1.14 | Crystal structure of human Carbonic Anhydrase II in complex with 4-(allyloxy)benzenesulfonamide |
| 6IC2 | 2019-05-15 | 1.15 | Polypharmacology of Epacadostat: a Potent and Selective Inhibitor of the Tumor Associated Carbonic Anhydrases IX and XII |
| 5SZ6 | 2016-12-28 | 1.15 | Carbonic anhydrase IX-mimic in complex with 4-(3-formylphenyl)-benzenesulfonamide |
| 2EU2 | 2006-07-11 | 1.15 | Human Carbonic Anhydrase II in complex with novel inhibitors |
| 2NXT | 2007-04-24 | 1.15 | Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II |
| 3MHO | 2010-10-20 | 1.15 | Crystal structure of human carbonic anhydrase isozyme II with 4-[N-(6-chloro-5-formyl-2-methylthiopyrimidin-4-yl)amino]benzenesulfonamide |
| 4Q06 | 2015-01-28 | 1.15 | Crystal structure of chimeric carbonic anhydrase IX with inhibitor |
| 5BYI | 2015-08-05 | 1.15 | Human carbonic anhydrase II with an azobenzene inhibitor (1d) |
| 4HF3 | 2013-10-23 | 1.15 | Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure |
| 4Q07 | 2015-01-28 | 1.15 | Crystal structure of chimeric carbonic anhydrase IX with inhibitor |
| 5JE7 | 2017-01-11 | 1.15 | Human carbonic anhydrase II (F131Y) complexed with benzo[d]thiazole-2-sulfonamide |
| 2FOV | 2006-04-04 | 1.15 | Human Carbonic Anhydrase II complexed with two-prong inhibitors |
| 3RYY | 2011-08-10 | 1.16 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 5NXI | 2018-01-17 | 1.16 | Carbonic Anhydrase II Inhibitor RA2 |
| 4ITO | 2014-03-26 | 1.16 | Human CA II inhibition by novel sulfonamide |
| 5MJN | 2017-12-06 | 1.17 | Three dimensional structure of human carbonic anhydrase II in complex with 5-[(4Chlorobenzyl)sulfanyl]thiophene-2-sulfonamide |
| 3M2Y | 2011-05-25 | 1.17 | Carbonic Anhydrase II in complex with novel sulfonamide inhibitor |
| 5JEG | 2017-01-11 | 1.19 | Human carbonic anhydrase II (V121I) complexed with benzo[d]thiazole-2-sulfonamide |
| 5JEP | 2017-01-11 | 1.19 | Human carbonic anhydrase II (T199S) complexed with benzo[d]thiazole-2-sulfonamide |
| 5JG5 | 2017-01-11 | 1.19 | Human carbonic anhydrase II (V121T/F131Y) complexed with benzo[d]thiazole-2-sulfonamide |
| 5NYA | 2018-01-17 | 1.2 | Carbonic Anhydrase II Inhibitor RA13 |
| 3RJ7 | 2012-02-29 | 1.2 | Human carbonic anhydrase II complexed with its inhibitor rhenium(I)triscarbonyl-cyclopentadienyl-carboxy-4-aminomethylbenzene-sulfonamide |
| 5NXG | 2018-01-17 | 1.2 | Carbonic Anhydrase II Inhibitor RA1 |
| 4FIK | 2012-06-27 | 1.2 | Human carbonic anhydrase II H64A complexed with thioxolone hydrolysis products |
| 5T74 | 2017-09-06 | 1.2 | Human carboanhydrase F131C_C206S double mutant in complex with 14 |
| 6QFW | 2019-04-17 | 1.2 | Human carbonic anhydrase II with bound IrCp* complex (cofactor 9) to generate an artificial transfer hydrogenase (ATHase) |
| 6R6F | 2019-12-18 | 1.2 | Crystal structure of human carbonic anhydrase isozyme II with 4-chloro-2-cyclohexylsulfanyl-N-(2-hydroxyethyl)-5-sulfamoyl-benzamide |
| 4Q09 | 2015-01-28 | 1.2 | Crystal structure of chimeric carbonic anhydrase XII with inhibitor |
| 6I2F | 2019-11-20 | 1.2 | Human Carbonic Anhydrase II in complex with 4-Propoxybenzenesulfonamide |
| 5NXO | 2018-01-17 | 1.2 | Carbonic Anhydrase II Inhibitor RA6 |
| 3RYV | 2011-08-10 | 1.2 | Carbonic Anhydrase complexed with N-ethyl-4-sulfamoylbenzamide |
| 2NNG | 2007-05-08 | 1.2 | Structure of inhibitor binding to Carbonic Anhydrase II |
| 6B4D | 2018-02-07 | 1.2 | Crystal structure of human carbonic anhydrase II in complex with a heteroaryl-pyrazole carboxylic acid derivative. |
| 5YUI | 2018-08-01 | 1.2 | CO2 release in human carbonic anhydrase II crystals: reveal histidine 64 and solvent dynamics |
| 5JES | 2017-01-11 | 1.21 | Human carbonic anhydrase II (V121T) complexed with benzo[d]thiazole-2-sulfonamide |
| 5EHV | 2016-03-09 | 1.21 | human carbonic anhydrase II in complex with ligand |
| 5JG3 | 2017-01-11 | 1.21 | Human carbonic anhydrase II (121T/N67Q) complexed with benzo[d]thiazole-2-sulfonamide |
| 6D1M | 2018-06-13 | 1.21 | Design, synthesis, and X-ray of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects |
| 5U0F | 2017-08-30 | 1.21 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 5TXY | 2017-08-30 | 1.21 | Identification of a New Zinc Binding Chemotype of by Fragment Screening on human carbonic anhydrase |
| 5EH5 | 2016-03-09 | 1.21 | human carbonic anhydrase II in complex with ligand |
| 3L14 | 2011-01-05 | 1.22 | Human Carbonic Anhydrase II complexed with Althiazide |
| 4YGN | 2015-03-25 | 1.23 | NaI--Interactions between Hofmeister Anions and the Binding Pocket of a Protein |
| 4CNX | 2015-02-04 | 1.23 | Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture |
| 5NXM | 2018-05-30 | 1.25 | Carbonic Anhydrase II Inhibitor RA1 |
| 2FOQ | 2006-02-28 | 1.25 | Human Carbonic Anhydrase II complexed with two-prong inhibitors |
| 5NXP | 2018-01-17 | 1.25 | Carbonic Anhydrase II Inhibitor RA7 |
| 3S71 | 2011-10-19 | 1.25 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 6NJ5 | 2019-10-02 | 1.25 | Thermostable variant of human carbonic anhydrase II with disordered tetrazine 2.0 at site 233 |
| 5YUJ | 2018-08-01 | 1.25 | CO2 release in human carbonic anhydrase II crystals: reveal histidine 64 and solvent dynamics |
| 5WEX | 2017-10-11 | 1.26 | Discovery of new selenoureido analogs of 4-(4-fluorophenylureido) benzenesulfonamides as carbonic anhydrase inhibitors |
| 3GZ0 | 2009-07-21 | 1.26 | Apo-human carbonic anhydrase II revisited: Implications of the loss of a metal in protein structure, stability and solvent network |
| 5U0E | 2017-08-30 | 1.27 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 5SZ5 | 2016-12-28 | 1.27 | Carbonic anhydrase IX-mimic in complex with 4-(2-methylphenyl)-benzenesulfonamide |
| 4Z1J | 2015-08-26 | 1.27 | Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV) |
| 6C7W | 2018-05-23 | 1.28 | Carbonic anhydrase 2 in complex with [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDRO-2-FURANYL]METHYL SULFAMATE inhibitor |
| 5G0C | 2016-05-25 | 1.28 | An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C |
| 3S8X | 2012-04-11 | 1.3 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[(4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide |
| 6ODZ | 2019-06-12 | 1.3 | Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects |
| 6QL2 | 2019-09-25 | 1.3 | Crystal structure of chimeric carbonic anhydrase VI with ethoxzolamide. |
| 5NEA | 2017-12-06 | 1.3 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(2-methyl-1,3-oxazol-5-yl)benzene-1-sulfonammide |
| 5DSM | 2016-05-04 | 1.3 | Structure of CO2 released holo-form of human carbonic anhydrase II with 25 min warming |
| 6OE0 | 2019-06-12 | 1.3 | Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects |
| 3S9T | 2012-04-18 | 1.3 | Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-{[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide |
| 4RH2 | 2015-11-11 | 1.3 | Crystal structure of human carbonic anhydrase II in complex with 2-(6-hydroxy-3-Oxo-3H-xanthen-9-yl)-5-{3-1-(4-sulfamoyl-phenyl)-1h-[1,2,3]triazol-4-ylmethyl-thioureido}-benzoic acid |
| 6GXE | 2019-05-08 | 1.3 | Carbonic Anhydrase CAIX mimic in complex with inhibitor JS14 |
| 5DSK | 2016-05-04 | 1.3 | Structure of CO2 released holo-form of human carbonic anhydrase II with 3 min warming |
| 5T72 | 2017-09-06 | 1.3 | Human carboanhydrase F131C_C206S double mutant in complex with 2 |
| 4QIY | 2015-04-15 | 1.3 | Crystal structure of human carbonic anhydrase isozyme II with inhibitor |
| 5N1S | 2017-12-27 | 1.3 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(1H-Indol-2-yl)-benzenesulfonamide |
| 5T71 | 2017-09-06 | 1.3 | Human carboanhydrase F131C_C206S double mutant in complex with SA-2 |
| 3PYK | 2011-07-13 | 1.3 | Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor |
| 5DSR | 2016-05-04 | 1.3 | Structure of CO2 released apo-form of human carbonic anhydrase II with 10 min warming |
| 5N1R | 2017-12-27 | 1.3 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4'-Pyrazol-1-ylmethyl-biphenyl-4-sulfonamide |
| 5E28 | 2016-01-20 | 1.3 | Crystal structure of human carbonic anhydrase II in complex with the 4-(4-aminophenyl)benzenesulfonamide inhibitor |
| 6UGQ | 2019-12-18 | 1.3 | Human Carbonic Anhydrase IX-mimic complexed with SB4-206 |
| 6NJ4 | 2019-10-02 | 1.3 | Thermostable variant of human carbonic anhydrase with disordered tetrazine 2.0 reacted with strained trans-cyclooctene at site 233 |
| 6UH0 | 2019-12-18 | 1.31 | Human Carbonic Anhydrase 2 in complex with SB4-202 |
| 6H3Q | 2019-07-17 | 1.31 | Crystal structure of human carbonic anhydrase II in complex with the 4-(5-(chloromethyl)-1,3-selenazol-2-yl)benzenesulfonamide |
| 6UGR | 2019-12-18 | 1.31 | Human Carbonic Anhydrase 2 complexed with SB4-208 |
| 3ZP9 | 2013-10-30 | 1.31 | Human Carbonic Anhydrase II as a Scaffold for an Artificial Transfer Hydrogenase |
| 6U4Q | 2020-01-22 | 1.31 | Carbonic anhydrase 2 in complex with SB4197 |
| 6UGZ | 2019-12-18 | 1.31 | Human Carbonic Anhydrase IX-mimic complexed with SB4-208 |
| 6UGP | 2019-12-18 | 1.31 | Human Carbonic Anhydrase 2 complexed with SB4-206 |
| 6QFX | 2019-04-17 | 1.32 | Human carbonic anhydrase II with bound IrCp* complex (cofactor 10) to generate an artificial transfer hydrogenase (ATHase) |
| 5ZXW | 2018-06-13 | 1.32 | Crystal structure of human carbonic anhydrase II crystallized by ammonium sulfate |
| 5THN | 2017-04-26 | 1.33 | Crystal Structure of 2-Hydroxycyclohepta-2,4,6-triene-1-thione bound to human carbonic anhydrase 2 |
| 5EKM | 2016-01-06 | 1.33 | Human Carbonic Anhydrase II complexed with a two-faced guest |
| 5EKH | 2016-01-06 | 1.34 | Human Carbonic Anhydrase II complexed with a two-faced guest |
| 4HEZ | 2013-10-23 | 1.34 | Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure |
| 5JDV | 2017-01-11 | 1.34 | Human carbonic anhydrase II (F131W) complexed with benzo[d]thiazole-2-sulfonamide |
| 4Z1K | 2015-08-26 | 1.35 | Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV) |
| 6QL3 | 2019-09-25 | 1.35 | Crystal structure of chimeric carbonic anhydrase VI with 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide |
| 5G03 | 2016-05-25 | 1.35 | An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C |
| 4BF1 | 2014-01-22 | 1.35 | Three dimensional structure of human carbonic anhydrase II in complex with 5-(1-naphthalen-1-yl-1,2,3-triazol-4-yl)thiophene-2-sulfonamide |
| 3KNE | 2011-05-18 | 1.35 | Carbonic Anhydrase II H64C mutant in complex with an in situ formed triazole |
| 4KUV | 2014-06-25 | 1.35 | Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(4-chlorophenylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor |
| 6GXB | 2019-05-08 | 1.35 | Carbonic Anhydrase CAIX mimic in complex with inhibitor JS13 |
| 4QK3 | 2015-03-04 | 1.35 | Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - [delta]230-240 |
| 5ULN | 2017-10-11 | 1.35 | Synthesis of novel seleno ureido containing compounds as SLC-0111 analogs. Investigations on carbonic anhydrases activity, glutathione peroxidase and X-ray crystallography |
| 3MYQ | 2011-02-02 | 1.35 | Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-[(1H-imidazo[4,5-c]quinolin-2-ylsulfanyl)acetyl]benzenesulfonamide |
| 4MDG | 2014-01-01 | 1.35 | Closo Carborane Carbonic Anhydrase Inhibitor |
| 3M1K | 2010-11-17 | 1.35 | Carbonic Anhydrase in complex with fragment |
| 5JQT | 2016-10-19 | 1.36 | Crystal structure of human carbonic anhydrase II in complex with Benzoxaborole at pH 7.4 |
| 5AML | 2015-04-08 | 1.36 | Three dimensional structure of human carbonic anhydrase II in complex with 2-(But-2-yn-1-ylsulfamoyl)-4-sulfamoylbenzoic acid |
| 6PGX | 2019-08-21 | 1.36 | Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity |
| 6U4T | 2020-01-22 | 1.36 | Carbonic anhydrase 9 in complex with SB4197 |
| 3RYZ | 2011-08-10 | 1.37 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 3M14 | 2011-05-25 | 1.38 | Carbonic Anhydrase II in complex with novel sulfonamide inhibitor |
| 3M1W | 2011-05-25 | 1.38 | Carbonic Anhyrdase II mutant W5CH64C with closed disulfide bond in complex with sulfate |
| 5EH8 | 2016-03-09 | 1.38 | human carbonic anhydrase II in complex with ligand |
| 3RYJ | 2011-08-10 | 1.39 | Carbonic Anhydrase complexed with 4-sulfamoyl-N-(2,2,2-trifluoroethyl)benzamide |
| 5EHW | 2016-03-09 | 1.39 | human carbonic anhydrase II in complex with ligand |
| 5VGY | 2017-08-30 | 1.39 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 3KIG | 2010-11-17 | 1.39 | Mutant carbonic anhydrase II in complex with an azide and an alkyne |
| 5WLU | 2018-08-01 | 1.39 | Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide |
| 5DSO | 2016-05-04 | 1.4 | Structure of CO2 bound apo-form of human carbonic anhydrase II with 0 sec (no) warming |
| 3S74 | 2011-10-19 | 1.4 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 5WLV | 2018-08-01 | 1.4 | Carbonic Anhydrase II in complex with aryloxy-2-hydroxypropylammine sulfonamide |
| 5DSP | 2016-05-04 | 1.4 | Structure of CO2 released apo-form of human carbonic anhydrase II with 40 sec warming |
| 5NY3 | 2018-01-17 | 1.4 | Carbonic Anhydrase II Inhibitor RA11 |
| 2WEO | 2009-11-10 | 1.4 | Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors |
| 5N25 | 2017-12-27 | 1.4 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-Pyridin-3-yl-benzenesulfonamide |
| 3SBI | 2012-04-11 | 1.4 | Crystal structure of human carbonic anhydrase isozyme II with 4-[(2-pyrimidinylsulfanyl)acetyl]benzenesulfonamide |
| 3M04 | 2011-05-25 | 1.4 | Carbonic Anhydrase II in complex with novel sulfonamide inhibitor |
| 6D1L | 2018-06-13 | 1.4 | Design, synthesis, and X-ray of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects |
| 3M5S | 2011-05-25 | 1.4 | Carbonic Anhydrase II mutant H64C in complex with carbonate |
| 4QSB | 2015-01-21 | 1.4 | Crystal structure of human carbonic anhydrase isozyme II with 3-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}benzenesulfonamide |
| 2QO8 | 2008-01-22 | 1.4 | Crystal structure of the complex of hcaii with an indane-sulfonamide inhibitor |
| 5JQ0 | 2016-10-19 | 1.4 | Crystal structure of human carbonic anhydrase II in complex with Benzoxaborole at pH=8.7 |
| 5E2K | 2016-01-20 | 1.4 | Crystal structure of human carbonic anhydrase II in complex with the 4-(3-aminophenyl)benzenesulfonamide inhibitor |
| 5BRW | 2015-06-17 | 1.4 | Catalytic Improvement of an Artificial Metalloenzyme by Computational Design |
| 5G01 | 2016-05-25 | 1.4 | An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C |
| 3M96 | 2011-02-02 | 1.4 | Crystal structure of human carbonic anhydrase isozyme II with 5-{[(5-bromo-1H-benzimidazol-2-yl)sulfanyl]acetyl}-2-chlorobenzenesulfonamide |
| 3MWO | 2010-06-09 | 1.4 | Human carbonic anhydrase II in a doubled monoclinic cell: a re-determination |
| 6UGN | 2019-12-18 | 1.41 | Human Carbonic Anhydrase 2 complexed with SB4-205 |
| 3IBU | 2009-09-22 | 1.41 | The crystal structure of the human carbonic anhydrase II in complex with an aliphatic sulfamate inhibitor |
| 5LVS | 2017-03-08 | 1.42 | Self-assembled protein-aromatic foldamer complexes with 2:3 and 2:2:1 stoichiometries |
| 6QL1 | 2019-09-25 | 1.42 | Crystal structure of chimeric carbonic anhydrase VI with 4-[(4,6-dimethylpyrimidin-2-yl)thio]-2,3,5,6-tetrafluorobenzenesulfonamide |
| 5EH7 | 2016-03-09 | 1.42 | human carbonic anhydrase II in complex with ligand |
| 5TI0 | 2017-04-26 | 1.42 | Crystal Structure of 2-Hydroxycyclohepta-2,4,6-triene-1-thione bound to human carbonic anhydrase 2 L198G |
| 6CEH | 2018-05-23 | 1.43 | Design, Synthesis, X-ray and Biological Activities of Selenides Bearing the Benzenesulfonamide Moiety as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology |
| 3HLJ | 2010-03-02 | 1.44 | Crystal structure of human carbonic anhydrase isozyme II with 3-methylthiobenzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonamide |
| 6HX5 | 2018-12-26 | 1.44 | Selenols: a new class of Carbonic Anhydrase inhibitors |
| 6NM0 | 2020-01-15 | 1.44 | Selective inhibition of carbonic anhydrase IX activity, using compound SLC-149, displays limited anticancer effects in breast cancer cell lines |
| 2QP6 | 2008-06-03 | 1.45 | The crystal structure of the complex of hcaII with a bioreductive antitumor derivative |
| 3OIM | 2011-07-06 | 1.45 | Human Carbonic anhydrase II bound by 2-Ethylestradiol 3-O-sulfamate |
| 4HEY | 2013-10-23 | 1.45 | Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure |
| 4Z0Q | 2015-08-26 | 1.45 | Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV) |
| 4Q8Y | 2015-03-11 | 1.45 | Crystal structure of 2-hydroxyisoquinoline-1(2H)-thione bound to human carbonic anhydrase II |
| 5DSL | 2016-05-04 | 1.45 | Structure of CO2 released holo-form of human carbonic anhydrase II with 10 min warming |
| 5YUK | 2018-08-01 | 1.45 | CO2 release in human carbonic anhydrase II crystals: reveal histidine 64 and solvent dynamics |
| 3OKV | 2011-07-06 | 1.45 | Human Carbonic Anhydrase II A65S, N67Q (CA IX mimic) bound with 2-Ethylestrone 3-O-sulfamate |
| 3OKU | 2011-07-06 | 1.45 | Human Carbonic Anhydrase II in complex with 2-Ethylestrone-3-O-sulfamate |
| 6OE1 | 2019-06-12 | 1.45 | Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects |
| 4E49 | 2012-06-27 | 1.45 | Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors |
| 5WG7 | 2018-02-07 | 1.45 | Human Carbonic Anhydrase II complexed with AceK |
| 4E4A | 2012-06-27 | 1.45 | Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors |
| 4KAP | 2013-07-10 | 1.45 | The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand |
| 2WEJ | 2009-11-10 | 1.45 | Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors |
| 5TY8 | 2017-08-30 | 1.45 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 6H6S | 2019-01-09 | 1.45 | Sad phasing on nickel-substituted human carbonic anhydrase II |
| 4CQ0 | 2014-04-16 | 1.45 | Cyclic secondary sulfonamides: unusually good inhibitors of cancer- related carbonic anhydrase enzymes |
| 4YWP | 2015-10-14 | 1.45 | Sucrose Binding Site in genetically engineered Carbonic anhydrase IX |
| 4YVY | 2016-03-30 | 1.45 | Crystal structure of human carbonic anhydrase II in complex with hydroxylamine-O-sulfonamide, a molecule incorporating two zinc-binding groups. |
| 4Q7W | 2015-03-11 | 1.45 | Crystal structure of 1-hydroxy-6-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 6QFV | 2019-04-17 | 1.45 | Human carbonic anhydrase II with bound IrCp* complex (cofactor 8) to generate an artificial transfer hydrogenase (ATHase) |
| 6UGO | 2019-12-18 | 1.46 | Human Carbonic Anhydrase IX-mimic complexed with SB4-205 |
| 6H29 | 2018-09-05 | 1.46 | HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BENZYL CARBAMATE |
| 2AW1 | 2006-07-04 | 1.46 | Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor Celecoxib |
| 2GD8 | 2007-02-06 | 1.46 | Crystal structure analysis of the human carbonic anhydrase II in complex with a 2-substituted estradiol bis-sulfamate |
| 3PO6 | 2011-04-06 | 1.47 | Crystal structure of human carbonic anhydrase II with 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide |
| 3OYQ | 2011-08-10 | 1.47 | Structure of Human Carbonic Anhydrase II complexed with 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE |
| 5TH4 | 2017-04-26 | 1.47 | Crystal Structure of 1-hydroxypyridine-2(1H)-thione bound to human carbonic anhydrase 2 L198G |
| 3V2M | 2012-12-26 | 1.47 | Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II |
| 4QEF | 2014-10-08 | 1.47 | Human Carbonic Anhydrase II V207I - cyanate inhibitor complex |
| 4Z1N | 2015-08-26 | 1.47 | Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV) |
| 3QYK | 2012-03-07 | 1.47 | Human Carbonic Anhydrase II complexed with triple ring benzene sulfonamide inhibitor |
| 3DD0 | 2009-03-03 | 1.48 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 2WD2 | 2010-03-31 | 1.49 | A chimeric microtubule disruptor with efficacy on a taxane resistant cell line |
| 3P5A | 2011-10-19 | 1.49 | Human Carbonic Anhydrase complexed with Sodium morpholinocarbodithioate |
| 4DZ7 | 2013-03-27 | 1.49 | hCA II in complex with novel sulfonamide inhibitors Set D |
| 3P58 | 2011-10-19 | 1.49 | Human Carbonic Anhydrase in complex with Benzyl (Methyl) Carbamodithoic Acid |
| 4DZ9 | 2013-03-27 | 1.49 | hCA II in complex with novel sulfonamide inhibitors Set D |
| 5WLR | 2018-08-01 | 1.49 | Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide |
| 3N3J | 2011-03-09 | 1.5 | Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor |
| 4ZWY | 2015-08-05 | 1.5 | Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor |
| 3MNA | 2011-04-20 | 1.5 | The crystal structure of human carbonic anhydrase Ii in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor |
| 3S75 | 2011-10-19 | 1.5 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 3DCW | 2009-03-03 | 1.5 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 5AMD | 2015-04-08 | 1.5 | Three dimensional structure of human carbonic anhydrase II in complex with 2-((2-Phenylethyl)sulfamoyl)-4-sulfamoylbenzoic acid |
| 4QY3 | 2014-12-03 | 1.5 | THE CRYSTAL STRUCTURE OF THE COMPLEX of HCAII WITH AN ORTHO-SUBSTITUTED BENZOIC ACID |
| 4GL1 | 2013-09-04 | 1.5 | Structure of H64A/N62L/N67L Human Carbonic Anhydrase II triple mutant |
| 4YGK | 2015-03-25 | 1.5 | NaSCN--Interactions between Hofmeister Anions and the Binding Pocket of a Protein |
| 1FR7 | 2001-01-17 | 1.5 | X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT |
| 3RG4 | 2012-02-22 | 1.5 | Crystal structure of the W5F mutant of human carbonic anhydrase II |
| 5N24 | 2017-12-27 | 1.5 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor b4'-Cyano-biphenyl-4-sulfonic acid amide |
| 2AX2 | 2006-01-03 | 1.5 | Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II |
| 4Q8Z | 2015-03-11 | 1.5 | Crystal structure of 1-hydroxy-4-methylpyridin-2(1H)-one bound to human carbonic anhydrase II |
| 6C7X | 2018-05-23 | 1.5 | Carbonic anhydrase 2 in complex with 2-chloro-5'-O-sulfamoyladenosine |
| 1OQ5 | 2004-03-23 | 1.5 | CARBONIC ANHYDRASE II IN COMPLEX WITH NANOMOLAR INHIBITOR |
| 3OIK | 2011-07-06 | 1.5 | Human Carbonic anhydrase II mutant A65S, N67Q (CA IX mimic) bound by 2-Ethylestradiol 3,17-O,O-bis-sulfamate |
| 4QSA | 2015-01-21 | 1.5 | Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-4-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}benzenesulfonamide |
| 3MMF | 2011-04-20 | 1.5 | Crystal structure of human carbonic anhydrase II in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor |
| 5THJ | 2017-04-26 | 1.5 | Crystal Structure of 2-hydroxycyclohepta-2,4,6-trien-1-one bound to human carbonic anhydrase 2 |
| 4R5B | 2014-10-15 | 1.5 | Human Carbonic Anhydrase II in Complex with a Carbohydrate-Based Sulfamate |
| 6MBY | 2019-03-13 | 1.5 | Carbonic Anhydrase II in complex with Ferulic Acid |
| 3RLD | 2012-02-08 | 1.5 | Crystal structure of the Y7I mutant of human carbonic anhydrase II |
| 4Q99 | 2015-03-11 | 1.5 | Crystal structure of 2-mercapto-4-methylphenol bound to human carbonic anhydrase II |
| 3MHM | 2010-10-20 | 1.5 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-benzylamino-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide |
| 3V5G | 2012-07-25 | 1.5 | Crystal structure of human carbonic anhydrase II in complex with the 4-sulfamido-benzenesulfonamide inhibitor |
| 3KOK | 2010-08-25 | 1.5 | Crystal structure of cobalt (II) human carbonic anhydrase II at pH 8.5 |
| 4JSS | 2013-06-19 | 1.5 | Human carbonic anhydrase II H94D bound to a bidentate inhibitor |
| 5DSQ | 2016-05-04 | 1.5 | Structure of CO2 released apo-form of human carbonic anhydrase II with 3 min warming |
| 5T75 | 2017-09-06 | 1.5 | Human carbonic anhydrase II G132C_C206S double mutant in complex with SA-2 |
| 4JSA | 2013-06-19 | 1.5 | Benzenesulfonamide complexed with hCAII H94D |
| 5E2S | 2016-01-20 | 1.5 | Crystal structure of human carbonic anhydrase II in complex with the 4-(2-iso-propylphenyl)benzenesulfonamide inhibitor |
| 3MZC | 2011-03-09 | 1.5 | Human carbonic ahydrase II in complex with a benzenesulfonamide inhibitor |
| 6NJ2 | 2019-10-02 | 1.5 | thermostable carbonic anhydrase II variant with tetrazine 2.0 at site 186 |
| 3P5L | 2011-10-19 | 1.5 | Human Carbonic Anhydrase complexed with sodium 4-cyano-4-phenylpiperidine-1-carbodithioate |
| 3OIL | 2011-07-06 | 1.5 | Human Carbonic anhydrase II mutant A65S, N67Q (CA IX mimic) bound by 2-Ethylestradiol 3-O-sulfamate |
| 3N0N | 2011-03-16 | 1.5 | Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor |
| 4BCW | 2013-02-06 | 1.5 | Carbonic anhydrase IX mimic in complex with (E)-2-(5-bromo-2- hydroxyphenyl)ethenesulfonic acid |
| 5EHE | 2016-11-09 | 1.5 | Crystal structure of human carbonic anhydrase isozyme II with 3-(benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide |
| 4ZX1 | 2015-10-28 | 1.5 | Engineered Carbonic Anhydrase IX mimic in complex with a glucosyl sulfamate inhibitor |
| 5TYA | 2017-08-30 | 1.5 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 4E3H | 2012-06-27 | 1.5 | Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors |
| 5TFX | 2017-08-09 | 1.5 | New method for synthesis of benzoxazole amide inhibitors of carbonic anhydrase |
| 3M98 | 2011-03-02 | 1.5 | Crystal structure of human carbonic anhydrase isozyme II with 5-(1H-benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide |
| 4E3F | 2012-06-27 | 1.5 | Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors |
| 3KON | 2010-08-25 | 1.5 | Crystal structure of cobalt (II) human carbonic anhydrase II at pH 11.0 |
| 3P3H | 2011-09-21 | 1.5 | Human carbonic anhydrase II in complex with p-(5-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide |
| 5THI | 2017-04-26 | 1.5 | Crystal Structure of 2-hydroxycyclohepta-2,4,6-trien-1-one bound to human carbonic anhydrase 2 L198G |
| 3TVN | 2012-08-08 | 1.5 | Human Carbonic Anhydrase II Proton Transfer Mutant |
| 3RZ1 | 2011-08-10 | 1.51 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 4YGL | 2015-03-25 | 1.51 | NaClO4--Interactions between Hofmeister Anions and the Binding Pocket of a Protein |
| 4MDL | 2014-01-01 | 1.52 | Meta Carborane Carbonic Anhydrase Inhibitor |
| 5JN7 | 2017-05-03 | 1.52 | Carbonic Anhydrase II In Complex WITH U-CH3 |
| 4QK2 | 2015-03-04 | 1.52 | Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - E234P |
| 5JN1 | 2017-05-03 | 1.52 | Carbonic Anhydrase IX-mimic IN Complex WITH U-CH3 |
| 4RN4 | 2015-01-28 | 1.53 | Human Carbonic anhydrases II in complex with a acetazolamide derivative comprising one hydrophobic and one hydrophilic tail moiety |
| 5TY9 | 2017-08-30 | 1.53 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 5WGP | 2018-02-07 | 1.53 | Human Carbonic Anhydrase IX-mimic complexed with AceK |
| 2CBA | 1993-10-31 | 1.54 | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES |
| 3OYS | 2011-08-10 | 1.54 | Human Carbonic Anhydrase II complexed with 2-{[4-AMINO-3-(3-HYDROXYPROP-1-YN-1-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL]METHYL}-5-METHYL-3-(2-METHYLPHENYL)QUINAZOLIN-4(3H)-ONE |
| 4N16 | 2014-06-18 | 1.54 | Structure of cholate bound to human carbonic anhydrase II |
| 5EZT | 2016-07-20 | 1.54 | Peracetylated Bovine Carbonic Anhydrase II |
| 5U0G | 2017-08-30 | 1.54 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 4Q90 | 2015-03-11 | 1.54 | Crystal structure of 4-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 1ZFQ | 2006-05-23 | 1.55 | carbonic anhydrase II in complex with ethoxzolamidphenole as sulfonamide inhibitor |
| 5AMG | 2015-04-08 | 1.55 | Three dimensional structure of human carbonic anhydrase II in complex with 2-(Pentylsulfamoyl)-4-sulfamoylbenzoic acid |
| 4Q8X | 2015-03-11 | 1.55 | Crystal structure of 1-hydroxy-5-(trifluoromethyl)pyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 4KV0 | 2014-06-25 | 1.55 | Crystal structure of human carbonic anhydrase II in complex with the 5-(3-tosylureido)pyridine-2-sulfonamide inhibitor |
| 3IBL | 2009-09-22 | 1.55 | The crystal structure of the human carbonic anhydrase II in complex with an aliphatic bis-sulfamate inhibitor |
| 5G0B | 2016-05-25 | 1.55 | An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C |
| 4Q87 | 2015-03-11 | 1.55 | Crystal structure of 1-hydroxy-4-(trifluoromethyl)pyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 3U3A | 2012-10-10 | 1.55 | structure of Human Carbonic Anhydrase II V143I |
| 2HNC | 2006-12-19 | 1.55 | Crystal structure of the human carbonic anhydrase II in complex with the 5-amino-1,3,4-thiadiazole-2-sulfonamide inhibitor. |
| 4E3G | 2012-06-27 | 1.55 | Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors |
| 2HL4 | 2007-05-22 | 1.55 | Crystal structure analysis of human carbonic anhydrase II in complex with a benzenesulfonamide derivative |
| 6CJV | 2018-08-08 | 1.55 | Carbonic anhydrase IX-mimic in complex with sucralose |
| 4Q9Y | 2015-03-11 | 1.55 | Crystal structure of 3-methylthiophenol bound to human carbonic anhydrase II |
| 5SZ1 | 2016-12-21 | 1.55 | Carbonic anhydrase II in complex with 4-(2-methylphenyl)-benzenesulfonamide |
| 5CLU | 2015-11-11 | 1.55 | THE CRYSTAL STRUCTURE OF THE COMPLEX of HCAII WITH A SACCHARINE DERIVATIVE |
| 6H34 | 2018-12-19 | 1.55 | The crystal structure of human carbonic anhydrase II in complex with 4-[(4-fluorophenyl)methyl]-1-piperazinyl]benzenesulfonamide. |
| 4MDM | 2014-01-01 | 1.55 | Nido-Carborane Carbonic Anhydrase Inhibitor |
| 4KUW | 2014-06-25 | 1.55 | Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(4-fluorophenylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor |
| 4Q83 | 2015-03-11 | 1.55 | Crystal structure of 1-hydroxy-3-(trifluoromethyl)pyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 4JS6 | 2013-06-19 | 1.55 | Crystal structure of inhibitor-free hCAII H94D |
| 4Q81 | 2015-03-11 | 1.55 | Crystal structure of 1-hydroxy-4,6-dimethylpyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 1ZFK | 2006-05-23 | 1.56 | carbonic anhydrase II in complex with N-4-sulfonamidphenyl-N'-4-methylbenzosulfonylurease as sulfonamide inhibitor |
| 2VVA | 2009-07-14 | 1.56 | Human carbonic anhydrase in complex with CO2 |
| 6GOT | 2018-10-03 | 1.56 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(phenethylthio)benzenesulfonamide |
| 3V3G | 2012-06-20 | 1.56 | Kinetic and structural studies of thermostabilized mutants of HCA II. |
| 5WLT | 2018-08-01 | 1.57 | Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide |
| 5A6H | 2016-05-25 | 1.57 | Synthesis, carbonic anhydrase inhibition and protein X-ray structure of the unusual natural product primary sulfonamide Psammaplin C |
| 6H33 | 2018-12-19 | 1.58 | The crystal structure of human carbonic anhydrase II in complex with 4-(4-phenyl)-4-hydroxy-1-piperidine-1-carbonyl)benzenesulfonamide. |
| 6RVK | 2019-08-28 | 1.58 | Crystal structure of hCA II in complex with Urea, N-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-N'-(phenylmethyl)- |
| 5FNK | 2016-03-02 | 1.59 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 5FNL | 2016-09-28 | 1.59 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 5U0D | 2017-08-30 | 1.59 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 5FNM | 2016-03-02 | 1.59 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 1FR4 | 2001-01-17 | 1.6 | X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT |
| 2FMG | 2006-05-23 | 1.6 | Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine and crystallographic analysis of their adducts with isozyme II: sterospecific recognition within the active site of an enzyme and its consequences for the drug design, structure with L-phenylalanine |
| 4Q7V | 2015-03-11 | 1.6 | Crystal structure of 1-hydroxy-5-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 2QOA | 2008-01-22 | 1.6 | Crystal structure of the complex of hcaii with an indane-sulfonamide inhibitor |
| 5SZ4 | 2016-12-21 | 1.6 | Carbonic anhydrase IX-mimic in complex with 4-(phenyl)-benzenesulfonamide |
| 3S76 | 2011-10-19 | 1.6 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 3DVC | 2008-11-11 | 1.6 | X-ray crystal structure of mutant N62T of human Carbonic Anhydrase II |
| 4E3D | 2012-06-27 | 1.6 | Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors |
| 4IWZ | 2013-12-11 | 1.6 | structure of hCAII in complex with an acetazolamide derivative |
| 5W8B | 2018-05-30 | 1.6 | Carbonic anhydrase II in complex with activating histamine pyridinium derivative |
| 2POV | 2007-07-24 | 1.6 | The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-chloro-benzene-1,3-disulfonamide |
| 5BRU | 2015-06-24 | 1.6 | Catalytic Improvement of an Artificial Metalloenzyme by Computational Design |
| 3U47 | 2012-10-10 | 1.6 | Human Carbonic Anhydrase II V143L |
| 1G0E | 2000-10-18 | 1.6 | SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH 4-METHYLIMIDAZOLE |
| 4ZX0 | 2015-10-28 | 1.6 | Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor |
| 5BRV | 2015-06-24 | 1.6 | Catalytic Improvement of an Artificial Metalloenzyme by Computational Design |
| 3R16 | 2011-05-25 | 1.6 | Human CAII bound to N-(4-sulfamoylphenyl)-2-(thiophen-2-yl) acetamide |
| 3M40 | 2010-10-20 | 1.6 | Crystal structure of human carbonic anhydrase isozyme II with 4-[N-(6-chloro-5-nitropyrimidin-4-yl)amino]benzenesulfonamide |
| 3DCC | 2009-03-03 | 1.6 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 2FMZ | 2006-05-23 | 1.6 | Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine, structure with D-Phenylalanine. |
| 3RYX | 2011-08-10 | 1.6 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 5FNI | 2016-03-02 | 1.6 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 2OSF | 2008-05-27 | 1.6 | Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study |
| 4HT0 | 2013-04-10 | 1.6 | Crystal structure of human carbonic anhydrase isozyme II with the inhibitor. |
| 3S72 | 2011-10-19 | 1.6 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 4ZWI | 2015-08-26 | 1.6 | Surface Lysine Acetylated Human Carbonic Anhydrase II in Complex with a Sulfamate-Based Inhibitor |
| 5JN3 | 2017-05-03 | 1.6 | Carbonic Anhydrase IX-mimic IN Complex WITH U-F |
| 2EU3 | 2006-07-11 | 1.6 | Human Carbonic anhydrase II in complex with novel inhibitors |
| 3DAZ | 2009-03-03 | 1.6 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 3OY0 | 2011-08-10 | 1.6 | Human Carbonic Anhydrase II complexed with 1-(4-(4-(2-(ISOPROPYLSULFONYL)PHENYLAMINO)-1H-PYRROLO[2,3-B]PYRIDIN-6-YLAMINO)-3-METHOXYPHENYL)PIPERIDIN-4-OL |
| 5E2R | 2015-11-04 | 1.6 | The crystal structure of the human carbonic anhydrase II in complex with a 1,1'-biphenyl-4-sulfonamide inhibitor |
| 1G0F | 2000-10-18 | 1.6 | SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMAN CARBONIC ANHYDRASE II |
| 3N4B | 2011-03-09 | 1.6 | Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor |
| 3DC9 | 2009-03-03 | 1.6 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 5TY1 | 2017-10-04 | 1.6 | Identification of a New Zinc Binding Chemotype by Fragment Screening |
| 6E8X | 2019-03-27 | 1.6 | CA IX mimic Complexed with Steroidal Sulfamate Compound STX 140 |
| 6NJ6 | 2019-10-02 | 1.6 | Thermostable variant of human carbonic anhydrase with tetrazine 2.0 at site 186 reacted with sTCO in crystallo |
| 4IDR | 2012-12-26 | 1.6 | Human Carbonic Anhydrase II Proton Transfer Double Mutant |
| 4K13 | 2014-04-09 | 1.6 | Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with dorzolamide |
| 3TVO | 2012-08-08 | 1.6 | Human Carbonic Anhydrase II Proton Transfer Double Mutant |
| 3DVD | 2008-11-11 | 1.6 | X-ray crystal structure of mutant N62D of human Carbonic Anhydrase II |
| 4LHI | 2014-07-02 | 1.6 | Crystal structure of human carbonic anhydrase isozyme II with 5-(phenylsulfonyl)thiophene-2-sulfonamide |
| 1CIL | 1994-01-31 | 1.6 | THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS |
| 4QK1 | 2015-03-04 | 1.6 | Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - K170P |
| 2OSM | 2008-02-12 | 1.6 | Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study |
| 3P3J | 2011-09-21 | 1.6 | Human carbonic anhydrase II in complex with p-(5-ruthenocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide |
| 2POU | 2007-07-24 | 1.6 | The crystal structure of the human carbonic anhydrase II in complex with 4,5-dichloro-benzene-1,3-disulfonamide |
| 4ILX | 2013-02-13 | 1.6 | Structure of human carbonic anhydrase II in complex with an adamantyl sulfonamide inhibitor |
| 4CNV | 2015-02-04 | 1.62 | Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture |
| 4ZWZ | 2015-08-05 | 1.62 | Engineered Carbonic Anhydrase IX mimic in complex with a glucosyl sulfamate inhibitor |
| 6B5A | 2018-09-05 | 1.62 | Carbonic anhydrase IX-mimic in complex with nitrogenous base-bearing benezenesulfonamide |
| 6EEA | 2018-11-28 | 1.63 | Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. |
| 4RIV | 2015-02-04 | 1.63 | A Carbonic Anhydrase IX Mimic in Complex with Saccharin |
| 4N0X | 2014-01-29 | 1.63 | Room temperature crystal structure of human carbonic anhydrase II in complex with thiophene-2-sulfonamide |
| 1TH9 | 2005-01-25 | 1.63 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 3V3J | 2012-06-20 | 1.63 | Kinetic and structural studies of thermostabilized mutants of HCA II. |
| 6EEH | 2018-11-28 | 1.63 | Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. |
| 5SZ2 | 2016-12-21 | 1.63 | Carbonic anhydrase II in complex with 4-(3-formylphenyl)-benzenesulfonamide |
| 4RFD | 2015-04-15 | 1.63 | Human carbonic anhydrase II in complex with 4-(4-sulfamoyl-phenoxy)-butylammonium |
| 4L5V | 2014-04-30 | 1.63 | The structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II |
| 4RUZ | 2015-04-22 | 1.63 | Crystal structure of human Carbonic Anhydrase II in complex with 4-ethoxybenzenesulfonamide |
| 5SZ0 | 2016-12-21 | 1.63 | Carbonic anhydrase II in complex with 4-(phenyl)-benzenesulfonamide |
| 2X7S | 2010-03-31 | 1.64 | Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors. |
| 6B59 | 2018-09-05 | 1.64 | Carbonic anhydrase II in complex with nitrogenous base-bearing benezenesulfonamide |
| 4R5A | 2014-10-15 | 1.64 | A Carbonic Anhydrase IX Mimic in Complex with a Carbohydrate-Based Sulfamate |
| 4RFC | 2015-04-15 | 1.64 | Human carbonic anhydrase II in complex with tert-butyl 4-(4-sulfamoylphenoxy)butylcarbamate |
| 3KOI | 2010-08-25 | 1.64 | Crystal structure of cobalt (III) human carbonic anhydrase II at pH 6.0 |
| 3T5Z | 2012-06-20 | 1.65 | Crystal structure of the human carbonic anhydrase II in complex with N-methoxy-benzenesulfonamide |
| 4R59 | 2014-10-15 | 1.65 | A Carbonic Anhydrase IX Mimic in Complex with a Carbohydrate-Based Sulfamate |
| 3SBH | 2012-04-11 | 1.65 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide |
| 3M2N | 2011-02-16 | 1.65 | Crystal structure of human carbonic anhydrase isozyme II with 4-{2-[N-(6-chloro-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide |
| 4MLX | 2014-07-02 | 1.65 | Structure of a bidentate 3-hydroxy-4H-pyran-4-thione ligand bound to hCAII |
| 3N2P | 2011-03-09 | 1.65 | Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor |
| 1ZGE | 2006-05-23 | 1.65 | carbonic anhydrase II in complex with p-Sulfonamido-o,o'-dichloroaniline as sulfonamide inhibitor |
| 2NWY | 2007-04-24 | 1.65 | Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II |
| 4Q7P | 2015-03-11 | 1.65 | Crystal Structure of 1-hydroxy-3-methylpyridine-2(1H)-thione bound to hCAII |
| 4RIU | 2015-02-04 | 1.65 | A Carbonic Anhydrase IX Mimic in Complex with a Saccharin-Based Inhibitor |
| 6EQU | 2017-12-13 | 1.65 | X-Ray crystal structure of the human carbonic anhydrase II adduct with a membrane-impermeant inhibitor |
| 3IGP | 2010-03-09 | 1.65 | Structure of inhibitor binding to Carbonic Anhydrase II |
| 3MNH | 2010-07-14 | 1.65 | Human Carbonic Anhydrase II Mutant K170A |
| 3RZ5 | 2011-08-10 | 1.65 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 4KUY | 2014-06-25 | 1.65 | Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(o-tolylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor |
| 3D9Z | 2009-03-03 | 1.65 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 5FLO | 2016-03-02 | 1.66 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 1Z9Y | 2006-05-23 | 1.66 | carbonic anhydrase II in complex with furosemide as sulfonamide inhibitor |
| 5FNH | 2016-03-02 | 1.66 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 2VVB | 2009-07-14 | 1.66 | Human carbonic anhydrase II in complex with bicarbonate |
| 4M2W | 2013-11-06 | 1.66 | Genetically engineered Carbonic Anhydrase IX in complex with Dorzolamide |
| 2CBB | 1993-10-31 | 1.67 | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES |
| 5FLT | 2016-03-02 | 1.67 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 2CBD | 1993-10-31 | 1.67 | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES |
| 5FNJ | 2016-03-02 | 1.67 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 5FLS | 2016-03-02 | 1.67 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 3M3X | 2010-10-20 | 1.68 | Crystal structure of human carbonic anhydrase isozyme II with 4-{2-[N-(6-methoxy-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide |
| 5FLR | 2016-03-02 | 1.68 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 3M1Q | 2011-05-25 | 1.69 | Carbonic Anhydrase II mutant W5C-H64C with opened disulfide bond |
| 5SZ3 | 2016-12-21 | 1.69 | Carbonic anhydrase II in complex with 4-(3-quinolinyl)-benzenesulfonamide |
| 3DV7 | 2008-11-11 | 1.7 | Role of Hydrophilic Residues in Proton Transfer During Catalysis by Human Carbonic Anhydrase II (N62A) |
| 5N0D | 2017-05-10 | 1.7 | Crystal structure of human carbonic anhydrase II in complex with (R)-4-(6,7-dihydroxy-1-phenyl-3,4-tetrahydroisoquinoline-1H-2-carbonyl)benzenesulfonamide. |
| 6RW1 | 2019-08-28 | 1.7 | Crystal structure of hCA II in complex with Urea, N-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-N'-(phenylmethyl)- |
| 4K1Q | 2014-04-09 | 1.7 | Structure of hCAIX mimic (hCAII with 5 mutations in active site) |
| 3D8W | 2009-03-03 | 1.7 | Use of a carbonic Anhydrase II, IX Active-site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 5LMD | 2016-10-19 | 1.7 | The crystal structure of hCA II in complex with a benzoxaborole inhibitor |
| 5NEE | 2017-12-06 | 1.7 | Crystal structure of human carbonic anhydrase II in complex with the inhibitor 5-[2-(morpholine-4-carbonyl)1,3-oxazol-5-yl)]thiophene-2-sulfonammide |
| 3CYU | 2008-05-27 | 1.7 | Human Carbonic Anhydrase II complexed with Cryptophane biosensor and xenon |
| 3MHI | 2010-10-20 | 1.7 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[(5-nitro-6-oxo-1,6-dihydro-4-pyrimidinyl)amino]methyl}benzenesulfonamide |
| 3U45 | 2012-10-10 | 1.7 | Human Carbonic Anhydrase II V143A |
| 2NWO | 2007-04-24 | 1.7 | Structural and kinetic effect of hydrophobic mutations in the active site of human carbonic anhydrase II |
| 4HEW | 2013-10-23 | 1.7 | Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure |
| 5DOG | 2016-09-28 | 1.7 | Crystal structure of human carbonic anhydrase isozyme II with 2-(Benzylamino)-3,5,6-trifluoro-4-[(2-phenylethyl)thio]benzene- sulfonamide |
| 3RZ8 | 2011-08-10 | 1.7 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 3DVB | 2008-11-11 | 1.7 | X-ray crystal structure of mutant N62V human Carbonic Anhydrase II |
| 4L5W | 2014-04-30 | 1.7 | Structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II |
| 1CAM | 1993-10-31 | 1.7 | STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 5L6K | 2017-03-01 | 1.7 | Crystal Structure of Human Carbonic Anhydrase II in Complex with a Quinoline Oligoamide Foldamer |
| 5J8Z | 2016-06-29 | 1.7 | Human carbonic anhydrase II in complex with ligand |
| 3DBU | 2009-03-03 | 1.7 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 3R17 | 2011-05-25 | 1.7 | hCarbonic anhydrase II bound to N-(2-fluoro.4-sulfamoylphenyl)-2-(thiophen-2-yl) acetamide |
| 3DC3 | 2009-03-03 | 1.7 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 4ITP | 2014-01-01 | 1.7 | Structure of human carbonic anhydrase II bound to a benzene sulfonamide |
| 1ZH9 | 2006-05-23 | 1.7 | carbonic anhydrase II in complex with N-4-Methyl-1-piperazinyl-N'-(p-sulfonamide)phenylthiourea as sulfonamide inhibitor |
| 3C7P | 2009-01-13 | 1.7 | Crystal structure of human carbonic anhydrase II in complex with STX237 |
| 6MBV | 2019-03-13 | 1.7 | Carbonic Anhydrase II in complex with Nicotinic Acid |
| 5FLQ | 2016-03-02 | 1.7 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 2Q1B | 2007-09-04 | 1.7 | Carbonic Anhydrase II in Complex with Saccharin |
| 4E5Q | 2013-03-27 | 1.7 | Human Carbonic Anhydrase II in complex with cyanate |
| 3M2Z | 2011-07-06 | 1.7 | Fragment tethered to Carbonic Anhydrase II H64C mutant |
| 4ZWX | 2015-10-28 | 1.7 | Engineered Carbonic Anhydrase IX mimic in complex with glucosyl sulfamate inhibitor |
| 3HKQ | 2009-10-13 | 1.7 | Human carbonic anhydrase II in complex with 1-S-D-Galactopyranosylsulfonamide |
| 3V2J | 2012-12-26 | 1.7 | Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II |
| 1YO1 | 2005-09-20 | 1.7 | Proton Transfer from His200 in Human Carbonic Anhydrase II |
| 3MHC | 2010-07-21 | 1.7 | Crystal structure of human cabonic anhydrase II in adduct with an adamantyl analogue of acetazolamide in a novel hydrophobic binding pocket |
| 2NXR | 2007-04-24 | 1.7 | Structural effects of hydrophobic mutations on the active site of human carbonic anhydrase II |
| 3M5E | 2010-10-20 | 1.7 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-chloro-5-formyl-2-methylthiopyrimidin-4-yl)amino]methyl}benzenesulfonamide |
| 1MUA | 1993-10-31 | 1.7 | STRUCTURE AND ENERGETICS OF A NON-PROLINE CIS-PEPTIDYL LINKAGE IN AN ENGINEERED PROTEIN |
| 2F14 | 2006-10-24 | 1.71 | Tne Crystal Structure of the Human Carbonic Anhydrase II in Complex with a Fluorescent Inhibitor |
| 5FLP | 2016-03-02 | 1.71 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 6RVL | 2019-08-28 | 1.72 | Crystal structure of hCA II with Urea, N-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-?N'-phenyl- |
| 6EEO | 2018-11-28 | 1.72 | Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. |
| 4M2V | 2013-11-06 | 1.72 | Genetically engineered Carbonic Anhydrase IX in complex with Brinzolamide |
| 3V3I | 2012-06-20 | 1.73 | Kinetic and structural studies of thermostabilized mutants of HCA II. |
| 3EFI | 2008-09-30 | 1.75 | Carbonic anhydrase activators: Kinetic and X-ray crystallographic study for the interaction of d- and l-tryptophan with the mammalian isoforms I-XIV |
| 3SAP | 2012-04-11 | 1.75 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[(5-butyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide |
| 3MNJ | 2010-07-14 | 1.75 | Human Carbonic Anhydrase II Mutant K170E |
| 2POW | 2007-07-24 | 1.75 | The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide |
| 4PYY | 2015-01-28 | 1.75 | Crystal structure of human carbonic anhydrase isozyme II with inhibitor |
| 5N0E | 2017-05-10 | 1.75 | Crystal structure of human carbonic anhydrase II in complex with (S)-4-(6,7-dihydroxy-1-phenyl-3,4-tetrahydroisoquinoline-1H-2-carbonyl)benzenesulfonamide. |
| 5FDC | 2016-05-18 | 1.75 | Crystal structure of Human Carbonic Anhydrase II in complex with the anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog. |
| 1LG5 | 2002-07-24 | 1.75 | Crystal Structure Analysis of the HCA II Mutant T199P in complex with beta-mercaptoethanol |
| 3T5U | 2012-06-20 | 1.75 | Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide |
| 4QJM | 2015-04-15 | 1.75 | Crystal structure of human carbonic anhydrase isozyme II with inhibitor |
| 1ZGF | 2006-05-23 | 1.75 | carbonic anhydrase II in complex with trichloromethiazide as sulfonamide inhibitor |
| 3MNK | 2010-07-14 | 1.75 | Human Carbonic Anhydrase II Mutant K170H |
| 3MNI | 2010-07-14 | 1.75 | Human Carbonic Anhydrase II Mutant K170D |
| 3S73 | 2011-12-21 | 1.75 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 1XQ0 | 2005-05-17 | 1.76 | Structure of human carbonic anhydrase II with 4-[(3-bromo-4-O-sulfamoylbenzyl)(4-cyanophenyl)amino]-4H-[1,2,4]-triazole |
| 4HBA | 2013-07-31 | 1.76 | Structural and Catalytic Characterization of a Thermal and Acid Stable Variant of Human Carbonic Anhydrase II Containing an Engineered Disulfide Bond |
| 6E92 | 2019-03-27 | 1.77 | CA IX mimic Complexed with Steroidal Sulfamate Compound STX 2845 |
| 4K0T | 2014-04-09 | 1.78 | Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with chlorzolamide |
| 5SZ7 | 2016-12-21 | 1.78 | Carbonic anhydrase IX-mimic in complex with 4-(3-quinolinyl)-benzenesulfonamide |
| 6NLV | 2020-01-15 | 1.79 | Selective inhibition of carbonic anhydrase IX activity, using compound SLC-149, displays limited anticancer effects in breast cancer cell lines |
| 3DCS | 2009-03-03 | 1.8 | Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties |
| 4Q49 | 2015-02-25 | 1.8 | Room temperature neutron crystal structure of apo human carbonic anhydrase at pH 7.5 |
| 1TG3 | 2005-01-25 | 1.8 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 2WD3 | 2010-02-23 | 1.8 | Highly Potent First Examples of Dual Aromatase-Steroid Sulfatase Inhibitors based on a Biphenyl Template |
| 2NWP | 2007-04-24 | 1.8 | Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II |
| 5O07 | 2017-08-02 | 1.8 | The crystal structure of the human carbonic anhydrase II in complex with a nitroimidazole sulfamate inhibitor |
| 1CNI | 1995-07-10 | 1.8 | X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE |
| 1YO0 | 2005-09-20 | 1.8 | Proton Transfer from His200 in Human Carbonic Anhydrase II |
| 2FNN | 2006-11-28 | 1.8 | Activation of human carbonic anhydrase II by exogenous proton donors |
| 2FNK | 2006-11-28 | 1.8 | Activation of Human Carbonic Anhydrase II by exogenous proton donors |
| 1G52 | 2000-11-08 | 1.8 | CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 3NB5 | 2011-04-20 | 1.8 | Human carbonic anhydrase II in complex with 2-(3-chloro-4-hydroxyphenyl)-N-(4-sulfamoylphenethyl)acetamide |
| 2HD6 | 2006-10-03 | 1.8 | Crystal structure of the human carbonic anhydrase II in complex with a hypoxia-activatable sulfonamide. |
| 1YO2 | 2005-09-20 | 1.8 | Proton Transfer from His200 in Human Carbonic Anhydrase II |
| 4KNI | 2013-11-06 | 1.8 | Crystal structure of human carbonic anhydrase isozyme II with 2-Chloro-4-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide |
| 4XE1 | 2015-03-18 | 1.8 | Human carbonic anhydrase II in complex with 6-SULFAMOYL-SACCHARIN |
| 1I9Q | 2001-03-28 | 1.8 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(3,4,5-TRIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 3ML2 | 2011-04-20 | 1.8 | Human carbonic anhydsase II in complex with an aryl sulfonamide inhibitor |
| 2FNM | 2006-11-28 | 1.8 | Activation of human carbonic anhdyrase II by exogenous proton donors |
| 3MNU | 2010-06-16 | 1.8 | Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron containing aromatic sulfamide with mammalian isoforms I-XV |
| 2NXS | 2007-04-24 | 1.8 | Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II |
| 6E91 | 2019-03-27 | 1.8 | CA IX mimic Complexed with Steroidal Sulfamate Compound STX 2484 |
| 6QFU | 2019-04-17 | 1.8 | Human carbonic anhydrase II with bound IrCp* complex (cofactor 7) to generate an artificial transfer hydrogenase (ATHase) |
| 3PJJ | 2012-01-18 | 1.8 | Synthetic Dimer of Human Carbonic Anhydrase II |
| 3M67 | 2010-11-03 | 1.8 | Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-[(6,7-dihydro-1H-[1,4]dioxino[2,3-f]benzimidazol-2-ylsulfanyl)acetyl]benzenesulfonamide |
| 3RZ0 | 2011-08-10 | 1.8 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 4PYX | 2015-01-28 | 1.8 | Crystal structure of human carbonic anhydrase isozyme II with inhibitor |
| 4Q7S | 2015-03-11 | 1.8 | Crystal Structure of 1-hydroxy-4-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II |
| 3M1J | 2011-01-19 | 1.8 | The crystal structure of a NAMI A-Carbonic Anhydrase II adduct discloses the mode of action of this novel anticancer metallodrug |
| 1ZSC | 1996-07-11 | 1.8 | CARBONIC ANHYDRASE II MUTANT E117Q, HOLO FORM |
| 4ZAO | 2015-10-14 | 1.8 | Genetically engineered Carbonic anhydrase IX |
| 3CAJ | 2008-04-08 | 1.8 | Crystal structure of the human carbonic anhydrase II in complex with ethoxzolamide |
| 1RAY | 1993-10-31 | 1.8 | THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE |
| 3T83 | 2011-10-19 | 1.8 | Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates |
| 3HKN | 2009-10-13 | 1.8 | Human carbonic anhydrase II in complex with (2,3,4,6-Tetra-O-acetyl-beta-D-galactopyranosyl) -(1-4)-1,2,3,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosylsulfonamide |
| 1CNJ | 1995-07-10 | 1.8 | X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE |
| 5GMN | 2017-05-24 | 1.8 | Crystal structure of human carbonic anhydrase II in complex with polmacoxib |
| 1CAI | 1993-10-31 | 1.8 | STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 2NWZ | 2007-04-24 | 1.8 | Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II |
| 3RZ7 | 2011-08-10 | 1.8 | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase |
| 1RZB | 1993-10-31 | 1.8 | X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES |
| 4QTL | 2015-04-15 | 1.8 | Crystal structure of human carbonic anhydrase isozyme II with inhibitor |
| 5EOI | 2016-11-23 | 1.8 | Crystal structure of copper bound human Carbonic anhydrase II |
| 4K0S | 2014-04-09 | 1.8 | Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with acetazolamide |
| 3HKU | 2009-10-13 | 1.8 | Human carbonic anhydrase II in complex with topiramate |
| 6BCC | 2018-02-28 | 1.8 | Joint X-ray/neutron structure of human carbonic anhydrase II in complex with ethoxzolamide |
| 4K0Z | 2014-04-09 | 1.8 | Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with methazolamide |
| 1THK | 2005-01-25 | 1.8 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 3FFP | 2009-08-18 | 1.81 | X ray structure of the complex between carbonic anhydrase II and LC inhibitors |
| 1XEG | 2005-09-27 | 1.81 | Crystal structure of human carbonic anhydrase II complexed with an acetate ion |
| 4BF6 | 2014-01-22 | 1.82 | Three dimensional structure of human carbonic anhydrase II in complex with 5-(1-(3-Cyanophenyl)-1H-1,2,3-triazol-4-yl)thiophene-2- sulfonamide |
| 2CBE | 1993-10-31 | 1.82 | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES |
| 1G45 | 2000-11-08 | 1.83 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE |
| 1G46 | 2000-11-08 | 1.84 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 1I9M | 2001-03-28 | 1.84 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4-DIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 1G4J | 2000-11-08 | 1.84 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE |
| 5FDI | 2016-05-18 | 1.85 | Crystal structure of Human Carbonic Anhydrase II with the anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog. |
| 3BET | 2008-10-07 | 1.85 | Crystal structure of the human carbonic anhydrase II in complex with STX 641 at 1.85 angstroms resolution |
| 4MO8 | 2013-10-30 | 1.85 | The crystal structure of the human carbonic anhydrase II in complex with N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide |
| 3EFT | 2009-09-08 | 1.85 | Crystal structure of the complex between Carbonic Anhydrase II and a spin-labeled sulfonamide incorporating TEMPO moiety |
| 4PQ7 | 2014-10-08 | 1.85 | The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide inhibitor |
| 3V3H | 2012-06-20 | 1.85 | Kinetic and structural studies of thermostabilized mutants of HCA II. |
| 4PXX | 2015-06-10 | 1.85 | Crystal structure of a highly thermal stabilized variant of Human Carbonic Anhydrase II |
| 4FL7 | 2012-08-15 | 1.85 | The crystal structure of human carbonic anhydrase II in complex with N-(Hydroxy)-benzamide |
| 1H9N | 1997-09-17 | 1.85 | H119N CARBONIC ANHYDRASE II |
| 1BV3 | 1999-09-28 | 1.85 | HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH UREA |
| 1I9N | 2001-03-28 | 1.86 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,5-DIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 1I9O | 2001-03-28 | 1.86 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4-TRIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 3S77 | 2011-10-19 | 1.86 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 1G3Z | 2000-11-08 | 1.86 | CARBONIC ANHYDRASE II (F131V) |
| 1G48 | 2000-11-08 | 1.86 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 1G54 | 2000-11-08 | 1.86 | CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE |
| 3M2X | 2011-05-25 | 1.87 | Carbonic Anhydrase II in complex with novel sulfonamide inhibitor |
| 6EBE | 2018-11-28 | 1.88 | Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. |
| 1CAH | 1993-10-31 | 1.88 | STRUCTURE OF COBALT CARBONIC ANHYDRASE COMPLEXED WITH BICARBONATE |
| 2CBC | 1993-10-31 | 1.88 | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES |
| 6EDA | 2018-11-28 | 1.88 | Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. |
| 3B4F | 2008-01-22 | 1.89 | Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies |
| 2X7T | 2010-03-31 | 1.89 | Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors. |
| 4JSW | 2013-06-19 | 1.9 | Human carbonic anhydrase II H94C |
| 1RZD | 1993-10-31 | 1.9 | X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES |
| 1RZE | 1993-10-31 | 1.9 | X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES |
| 1RAZ | 1993-10-31 | 1.9 | THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE |
| 1CAN | 1994-01-31 | 1.9 | CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS |
| 3MHL | 2010-10-20 | 1.9 | Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-methoxy-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide |
| 1UGE | 1997-04-01 | 1.9 | HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY LEU (A65L) |
| 3BL0 | 2008-01-22 | 1.9 | Carbonic anhydrase inhibitors. Interaction of 2-N,N-Dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies |
| 1TG9 | 2005-01-25 | 1.9 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 1RZA | 1993-10-31 | 1.9 | X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES |
| 1CAK | 1993-10-31 | 1.9 | STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 1BIC | 1993-10-31 | 1.9 | CRYSTALLOGRAPHIC ANALYSIS OF THR-200-> HIS HUMAN CARBONIC ANHYDRASE II AND ITS COMPLEX WITH THE SUBSTRATE, HCO3- |
| 1YDB | 1995-02-14 | 1.9 | STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II |
| 1CNG | 1995-07-10 | 1.9 | X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE |
| 2CA2 | 1990-01-15 | 1.9 | CRYSTALLOGRAPHIC STUDIES OF INHIBITOR BINDING SITES IN HUMAN CARBONIC ANHYDRASE II. A PENTACOORDINATED BINDING OF THE SCN-ION TO THE ZINC AT HIGH P*H |
| 1CAZ | 1993-10-31 | 1.9 | WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE |
| 2H4N | 1997-09-17 | 1.9 | H94N CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE |
| 1CAO | 1994-01-31 | 1.9 | CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS |
| 3K7K | 2010-01-26 | 1.9 | Crystal structure of the complex between Carbonic Anhydrase II and anions |
| 1CNX | 1995-11-14 | 1.9 | SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS |
| 5JMZ | 2017-05-03 | 1.9 | Carbonic Anhydrase IX-mimic IN Complex WITH U-NO2 |
| 2HKK | 2007-05-22 | 1.9 | Carbonic anhydrase activators: Solution and X-ray crystallography for the interaction of andrenaline with various carbonic anhydrase isoforms |
| 1RZC | 1993-10-31 | 1.9 | X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES |
| 5LLH | 2017-08-16 | 1.9 | Crystal structure of human carbonic anhydrase isozyme II with 4-(1,3-Benzothiazol-2-ylthio)-2,3,5,6-tetrafluorobenzenesulfonamide |
| 4JSZ | 2013-06-19 | 1.9 | Benzenesulfonamide bound to hCAII H94C |
| 1F2W | 2000-06-08 | 1.9 | THE MECHANISM OF CYANAMIDE HYDRATION CATALYZED BY CARBONIC ANHYDRASE II REVEALED BY CRYOGENIC X-RAY DIFFRACTION |
| 3RG3 | 2012-02-22 | 1.9 | Crystal structure of the W5E mutant of human carbonic anhydrase II |
| 6E8P | 2019-04-03 | 1.9 | CA IX mimic Complexed with Steroidal Sulfamate Compound STX 49 |
| 1CRA | 1994-01-31 | 1.9 | THE COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND THE AROMATIC INHIBITOR 1,2,4-TRIAZOLE |
| 5LLE | 2017-08-16 | 1.9 | Crystal structure of human carbonic anhydrase isozyme II with 4-(1-Adamantylamino)-2,3,5,6-tetrafluorobenzenesulfonamide |
| 5A25 | 2015-05-20 | 1.9 | Rational engineering of a mesophilic carbonic anhydrase to an extreme halotolerant biocatalyst |
| 3F4X | 2009-03-17 | 1.9 | Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules make the difference |
| 1CAJ | 1993-10-31 | 1.9 | STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 1BCD | 1993-10-31 | 1.9 | X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND A NEW TOPICAL INHIBITOR, TRIFLUOROMETHANE SULPHONAMIDE |
| 2H15 | 2007-03-27 | 1.9 | Carbonic anhydrase inhibitors: Clashing with Ala65 as a means of designing isozyme-selective inhibitors that show low affinity for the ubiquitous isozyme II |
| 3DD8 | 2008-08-12 | 1.9 | Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD-486019 with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies |
| 2Q1Q | 2007-09-11 | 1.9 | Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies |
| 1LGD | 2002-07-24 | 1.9 | Crystal Structure Analysis of HCA II Mutant T199P in Complex with Bicarbonate |
| 1I9P | 2001-03-28 | 1.92 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4,6-TRIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 1IF4 | 2001-05-02 | 1.93 | Carbonic Anhydrase II Complexed With 4-fluorobenzenesulfonamide |
| 1I8Z | 2001-03-28 | 1.93 | CARBONIC ANHYDRASE II COMPLEXED WITH AL-6629 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-METHOXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE |
| 3IBI | 2009-09-22 | 1.93 | The crystal structure of the human carbonic anhydrase II in complex with an aliphatic sulfamate inhibitor |
| 1I9L | 2001-03-28 | 1.93 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(4-FLUOROPHENYL)METHYL]-BENZAMIDE |
| 6H2Z | 2018-12-19 | 1.94 | The crystal structure of human carbonic anhydrase II in complex with 4-(4-phenylpiperidine-1-carbonyl)benzenesulfonamide. |
| 1IF8 | 2001-05-02 | 1.94 | Carbonic Anhydrase II Complexed With (S)-N-(3-Indol-1-yl-2-methyl-propyl)-4-sulfamoyl-benzamide |
| 1G53 | 2000-11-08 | 1.94 | CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE |
| 1TTM | 2004-10-05 | 1.95 | Human carbonic anhydrase II complexed with 667-coumate |
| 1V9E | 2004-02-10 | 1.95 | Crystal Structure Analysis of Bovine Carbonic Anhydrase II |
| 4QSI | 2015-01-21 | 1.95 | Crystal structure of human carbonic anhydrase isozyme II with 5-{[(4-tert-buthyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}-2-chlorobenzenesulfonamide |
| 3M5T | 2011-05-25 | 1.95 | Fragment tethered to Carbonic Anhydrase II H64C mutant |
| 2Q38 | 2007-10-02 | 1.95 | Carbonic Anhydrase II in complex with Saccharin at 1.95 Angstrom |
| 1YDC | 1995-02-14 | 1.95 | STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II |
| 1G4O | 2000-11-08 | 1.96 | CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-PHENYLMETHYLBENZAMIDE |
| 1IF7 | 2001-05-02 | 1.98 | Carbonic Anhydrase II Complexed With (R)-N-(3-Indol-1-yl-2-methyl-propyl)-4-sulfamoyl-benzamide |
| 5L3O | 2017-03-01 | 1.98 | Crystal Structure of Human Carbonic Anhydrase II in Complex with a Quinoline Oligoamide Foldamer |
| 3K2F | 2009-11-17 | 1.98 | Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma |
| 3S78 | 2011-10-19 | 1.98 | The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase |
| 4M2R | 2013-11-06 | 1.99 | Human Carbonic Anhydrase II in complex with Brinzolamide |
| 5EIJ | 2016-11-09 | 1.99 | Carbonic Anhydrase II in complex with Sulfonamide Inhibitor |
| 1T9N | 2005-01-25 | 2.0 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 1UGC | 1997-04-01 | 2.0 | HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY HIS (A65H) |
| 1ZE8 | 2005-10-18 | 2.0 | Carbonic anhydrase II in complex with a membrane-impermeant sulfonamide inhibitor |
| 1TB0 | 2005-01-25 | 2.0 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 3P55 | 2011-10-12 | 2.0 | Human carbonic anhydrase II in complex with p-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide |
| 3CA2 | 1990-01-15 | 2.0 | CRYSTALLOGRAPHIC STUDIES OF INHIBITOR BINDING SITES IN HUMAN CARBONIC ANHYDRASE II. A PENTACOORDINATED BINDING OF THE SCN-ION TO THE ZINC AT HIGH P*H |
| 1FSN | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT |
| 1FQL | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT |
| 1HEC | 1992-10-15 | 2.0 | STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II |
| 3T84 | 2011-10-19 | 2.0 | Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates |
| 6BBS | 2018-02-28 | 2.0 | Joint X-ray/neutron structure of human carbonic anhydrase II in complex with brinzolamide |
| 1HEA | 1992-10-15 | 2.0 | CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) (HCA II) (E.C.4.2.1.1) MUTANT WITH LEU 198 REPLACED BY ARG (L198R) |
| 1CNW | 1995-11-14 | 2.0 | SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS |
| 2EZ7 | 2006-07-18 | 2.0 | Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII and XIV with L- and D-histidine and crystallographic analysis of their adducts with isoform II: engineering proton transfer processes within the active site of an enzyme |
| 1CA2 | 1990-01-15 | 2.0 | REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION |
| 4G0C | 2012-09-19 | 2.0 | Neutron structure of acetazolamide-bound human carbonic anhydrase II reveal molecular details of drug binding. |
| 4M2U | 2013-11-06 | 2.0 | Carbonic Anhydrase II in complex with Dorzolamide |
| 3TMJ | 2011-11-09 | 2.0 | Joint X-ray/neutron structure of human carbonic anhydrase II at pH 7.8 |
| 1TEU | 2005-01-25 | 2.0 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 1TEQ | 2005-01-25 | 2.0 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 1IF5 | 2001-05-02 | 2.0 | Carbonic Anhydrase II Complexed With 2,6-difluorobenzenesulfonamide |
| 1FQN | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT |
| 3T82 | 2011-10-19 | 2.0 | Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates |
| 1AVN | 1997-12-24 | 2.0 | HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH THE HISTAMINE ACTIVATOR |
| 1H4N | 1997-09-17 | 2.0 | H94N CARBONIC ANHYDRASE II COMPLEXED WITH TRIS |
| 1IF9 | 2001-05-02 | 2.0 | Carbonic Anhydrase II Complexed With N-[2-(1H-Indol-5-yl)-butyl]-4-sulfamoyl-benzamide |
| 1HEB | 1992-10-15 | 2.0 | STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II |
| 3P4V | 2011-04-20 | 2.0 | Human carbonic anhydrase II in complex with (+)-Xylariamide A |
| 1UGB | 1997-01-27 | 2.0 | HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY GLY (A65G) |
| 1TE3 | 2005-01-25 | 2.0 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 2ABE | 2005-10-25 | 2.0 | Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators |
| 1I90 | 2001-03-28 | 2.0 | CARBONIC ANHYDRASE II COMPLEXED WITH AL-8520 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 4-AMINO-3,4-DIHYDRO-2-(3-METHOXYPROPYL)-, 1,1-DIOXIDE, (R) |
| 1UGA | 1997-01-27 | 2.0 | HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY PHE (A65F) |
| 5BNL | 2015-07-15 | 2.0 | Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins |
| 4MLT | 2014-07-02 | 2.0 | Structure of a monodentate 3-hydroxy-4H-pyran-4-thione ligand bound to hCAII |
| 3NJ9 | 2011-06-22 | 2.0 | Crystal structure of carbonic anhydrase II in complex with a Nir inhibitor |
| 1ZSB | 1996-07-11 | 2.0 | CARBONIC ANHYDRASE II MUTANT E117Q, TRANSITION STATE ANALOGUE ACETAZOLAMIDE |
| 1UGD | 1997-01-27 | 2.0 | HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY SER (A65S) |
| 1FQR | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT |
| 1HED | 1992-10-15 | 2.0 | STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II |
| 1FQM | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT |
| 3KWA | 2010-07-14 | 2.0 | Polyamines inhibit carbonic anhydrases |
| 1I91 | 2001-03-28 | 2.0 | CARBONIC ANHYDRASE II COMPLEXED WITH AL-6619 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-HYDROXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE |
| 1AM6 | 1998-06-24 | 2.0 | CARBONIC ANHYDRASE II INHIBITOR: ACETOHYDROXAMATE |
| 1FSQ | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT |
| 1FSR | 2001-01-17 | 2.0 | X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT |
| 1UGF | 1997-04-01 | 2.0 | HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY THR (A65T) |
| 3F8E | 2009-10-06 | 2.0 | Coumarins are a novel class of suicide carbonic anhydrase inhibitors |
| 4Y0J | 2015-04-22 | 2.0 | H/D exchanged human carbonic anhydrase II pH 6 room temperature neutron crystal structure. |
| 3KKX | 2010-01-12 | 2.0 | Neutron structure of human carbonic anhydrase II |
| 1TBT | 2005-01-25 | 2.0 | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II |
| 3IEO | 2010-01-26 | 2.0 | The coumarin-binding site in carbonic anhydrase: the antiepileptic lacosamide as an example |
| 4KNJ | 2013-11-06 | 2.0 | Crystal structure of human carbonic anhydrase isozyme II with 2-Chloro-4-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide |
| 3V3F | 2012-06-20 | 2.0 | Kinetic and structural studies of thermostabilized mutants of HCA II. |
| 2GEH | 2006-06-20 | 2.0 | N-Hydroxyurea, a versatile zinc binding function in the design of metalloenzyme inhibitors |
| 4Z1E | 2015-08-26 | 2.01 | Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV) |
| 1XPZ | 2005-05-17 | 2.02 | Structure of human carbonic anhydrase II with 4-[4-O-sulfamoylbenzyl)(4-cyanophenyl)amino]-4H-[1,2,4]-triazole |
| 4CNW | 2015-02-04 | 2.03 | Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture |
| 1G1D | 2000-11-08 | 2.04 | CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE |
| 5FNG | 2016-03-02 | 2.05 | Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination |
| 1CNH | 1995-07-10 | 2.05 | X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE |
| 4L5U | 2014-04-30 | 2.05 | The structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II |
| 6RVF | 2019-08-28 | 2.07 | Crystal structure of hCA II in complex with Urea, N-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-N'-phenyl |
| 2WEH | 2009-11-10 | 2.09 | Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors |
| 1IF6 | 2001-05-02 | 2.09 | Carbonic Anhydrase II Complexed With 3,5-difluorobenzenesulfonamide |
| 1BN4 | 1999-05-18 | 2.1 | CARBONIC ANHYDRASE II INHIBITOR |
| 1EOU | 2002-02-13 | 2.1 | CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH AN ANTICONVULSANT SUGAR SULFAMATE |
| 1OKL | 1997-01-11 | 2.1 | CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKL INHIBITOR 5-DIMETHYLAMINO-NAPHTHALENE-1-SULFONAMIDE |
| 3HFP | 2010-05-19 | 2.1 | Crystal structure of teh complex between CA II and the activator MAI |
| 1CIN | 1994-01-31 | 2.1 | THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS |
| 1DCB | 1993-07-15 | 2.1 | STRUCTURE OF AN ENGINEERED METAL BINDING SITE IN HUMAN CARBONIC ANHYDRASE II REVEALS THE ARCHITECTURE OF A REGULATORY CYSTEINE SWITCH |
| 3NI5 | 2011-06-22 | 2.1 | Carbonic anhydrase inhibitor: C1 family |
| 1YDA | 1995-02-14 | 2.1 | STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II |
| 4CA2 | 1992-10-31 | 2.1 | ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II |
| 2O4Z | 2007-05-15 | 2.1 | Crystal structure of the Carbonic Anhydrase II complexed with hydroxysulfamide inhibitor |
| 1CAY | 1993-10-31 | 2.1 | WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE |
| 5CA2 | 1992-10-31 | 2.1 | CONFORMATIONAL MOBILITY OF HIS-64 IN THE THR-200 (RIGHT ARROW) SER MUTANT OF HUMAN CARBONIC ANHYDRASE II |
| 1BN1 | 1999-05-18 | 2.1 | CARBONIC ANHYDRASE II INHIBITOR |
| 3RGE | 2012-02-22 | 2.1 | Crystal structure of the W5H mutant of human carbonic anhydrase II |
| 2HOC | 2006-10-10 | 2.1 | Crystal structure of the human carbonic anhydrase II in complex with the 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide inhibitor |
| 1CIM | 1994-01-31 | 2.1 | THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS |
| 1YDD | 1995-02-14 | 2.1 | STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II |
| 3BL1 | 2008-07-01 | 2.1 | Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited old leads for new applications |
| 2X7U | 2010-03-31 | 2.12 | Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors. |
| 1BNT | 1999-06-15 | 2.15 | CARBONIC ANHYDRASE II INHIBITOR |
| 5UMC | 2017-12-06 | 2.15 | Synthesis of novel seleno ureido containing compounds as SLC-0111 analogs. Investigations on carbonic anhydrases activity, glutathione peroxidase and X-ray crystallography |
| 1CNK | 1995-07-10 | 2.15 | X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE |
| 4LP6 | 2013-10-23 | 2.15 | Crystal Structure of Human Carbonic Anhydrase II in complex with a quinoline oligoamide foldamer |
| 1BNU | 1999-06-15 | 2.15 | CARBONIC ANHYDRASE II INHIBITOR |
| 1CVD | 1994-12-20 | 2.2 | STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE |
| 1H9Q | 1997-09-17 | 2.2 | H119Q CARBONIC ANHYDRASE II |
| 4CAC | 1994-01-31 | 2.2 | REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION |
| 1CAL | 1993-10-31 | 2.2 | STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 3P44 | 2011-10-12 | 2.2 | Human carbonic anhydrase II in complex with p-(4-ruthenocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide |
| 1BN3 | 1999-05-18 | 2.2 | CARBONIC ANHYDRASE II INHIBITOR |
| 5CAC | 1994-01-31 | 2.2 | REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION |
| 1LG6 | 2002-07-24 | 2.2 | Crystal Structure Analysis of HCA II Mutant T199P in Complex with Thiocyanate |
| 3IBN | 2009-09-22 | 2.2 | The crystal structure of the human carbonic anhydrase II in complex with an aliphatic bis-sulfamate inhibitor |
| 5L70 | 2017-06-21 | 2.2 | CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER |
| 1OKM | 1997-01-11 | 2.2 | CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKM INHIBITOR 4-SULFONAMIDE-[1-(4-AMINOBUTANE)]BENZAMIDE |
| 1XEV | 2005-09-20 | 2.2 | Crystal structure of human carbonic anhydrase II in a new crystal form |
| 1CNC | 1994-10-15 | 2.2 | COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES |
| 1CCT | 1995-02-07 | 2.2 | STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY |
| 1DCA | 1993-07-15 | 2.2 | STRUCTURE OF AN ENGINEERED METAL BINDING SITE IN HUMAN CARBONIC ANHYDRASE II REVEALS THE ARCHITECTURE OF A REGULATORY CYSTEINE SWITCH |
| 1UGG | 1997-01-27 | 2.2 | HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY SER (A65S)-ORTHORHOMBIC FORM |
| 6ECZ | 2018-11-28 | 2.21 | Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. |
| 6Q3O | 2019-12-25 | 2.23 | PROTEIN-AROMATIC FOLDAMER COMPLEX CRYSTAL STRUCTURE |
| 1CVA | 1993-10-31 | 2.25 | STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 1CVE | 1994-11-30 | 2.25 | STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE |
| 1BNW | 1999-06-15 | 2.25 | CARBONIC ANHYDRASE II INHIBITOR |
| 1A42 | 1999-03-23 | 2.25 | HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH BRINZOLAMIDE |
| 1CVF | 1994-11-30 | 2.25 | STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE |
| 1CCU | 1995-02-07 | 2.25 | STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY |
| 1KWR | 2003-01-07 | 2.25 | HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH INHIBITOR 0134-36 |
| 4CNR | 2015-02-04 | 2.29 | Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture |
| 1LZV | 2002-10-23 | 2.3 | Site-Specific Mutant (Tyr7 replaced with His) of Human Carbonic Anhydrase II |
| 1BNN | 1999-05-18 | 2.3 | CARBONIC ANHYDRASE II INHIBITOR |
| 1HVA | 1993-10-31 | 2.3 | ENGINEERING THE ZINC BINDING SITE OF HUMAN CARBONIC ANHYDRASE II: STRUCTURE OF THE HIS-94-> CYS APOENZYME IN A NEW CRYSTALLINE FORM |
| 1CNY | 1995-11-14 | 2.3 | SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS |
| 1HCA | 1992-10-15 | 2.3 | UNEXPECTED PH-DEPENDENT CONFORMATION OF HIS-64, THE PROTON SHUTTLE OF CARBONIC ANHYDRASE II. |
| 1CVH | 1995-02-07 | 2.3 | STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE |
| 1CVC | 1994-01-31 | 2.3 | REDESIGNING THE ZINC BINDING SITE OF HUMAN CARBONIC ANHYDRASE II: STRUCTURE OF A HIS2ASP-ZN2+ METAL COORDINATION POLYHEDRON |
| 1CA3 | 1992-10-15 | 2.3 | UNEXPECTED PH-DEPENDENT CONFORMATION OF HIS-64, THE PROTON SHUTTLE OF CARBONIC ANHYDRASE II. |
| 1CCS | 1995-02-07 | 2.35 | STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY |
| 1CNB | 1994-10-15 | 2.35 | COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES |
| 3HKT | 2009-10-13 | 2.36 | Human carbonic anhydrase II in complex with alpha-D-Glucopyranosyl-(1->4)-1-thio-beta-D-glucopyranosylsulfonamide |
| 12CA | 1992-10-15 | 2.4 | ALTERING THE MOUTH OF A HYDROPHOBIC POCKET. STRUCTURE AND KINETICS OF HUMAN CARBONIC ANHYDRASE II MUTANTS AT RESIDUE VAL-121 |
| 7CA2 | 1992-07-15 | 2.4 | ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II |
| 8CA2 | 1992-07-15 | 2.4 | ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II |
| 1OKN | 1997-01-11 | 2.4 | CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKN INHIBITOR 4-SULFONAMIDE-[1-(4-N-(5-FLUORESCEIN THIOUREA)BUTANE)] |
| 1CVB | 1993-10-31 | 2.4 | STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II |
| 1BNV | 1999-02-16 | 2.4 | CARBONIC ANHYDRASE II INHIBITOR |
| 3T85 | 2011-10-19 | 2.4 | Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates |
| 1BNQ | 1999-06-15 | 2.4 | CARBONIC ANHYDRASE II INHIBITOR |
| 1ZSA | 1996-07-11 | 2.5 | CARBONIC ANHYDRASE II MUTANT E117Q, APO FORM |
| 6CA2 | 1992-07-15 | 2.5 | ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II |
| 1BNM | 1999-05-18 | 2.6 | CARBONIC ANHYDRASE II INHIBITOR |
| 1KWQ | 2003-01-07 | 2.6 | HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH INHIBITOR 2000-07 |
| 5L6T | 2017-06-21 | 2.65 | CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER |
| 6Q9T | 2019-09-18 | 2.68 | Protein-aromatic foldamer complex crystal structure |
| 9CA2 | 1992-07-15 | 2.8 | ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II |
| 5L9E | 2017-06-21 | 2.9 | CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER |
| 6HZX | 2019-09-18 | 2.91 | Protein-aromatic foldamer complex crystal structure |
| 1V9I | 2004-02-10 | 2.95 | Crystal Structure Analysis of the site specific mutant (Q253C) of bovine carbonic anhydrase II |
| 1G6V | 2000-11-22 | 3.5 | Complex of the camelid heavy-chain antibody fragment CAB-CA05 with bovine carbonic anhydrase |