Thermal denaturation of erythrocyte carbonic anhydrase.


Abstract

An experimental study on the thermal behaviour of erythrocyte carbonic anhydrase was carried out with the main aim to estimate the thermodynamic parameters that control the stability of the enzyme. The effects of thermal denaturation on the catalytic properties of the enzyme were also investigated. Below 60 degrees C the enzyme was found to be very stable, whereas between 60 and 65 degrees C a drastic decrease in the biological activity was observed. From the obtained results some considerations were made about the stabilization of the active form of the protein. Study holds ProTherm entries: 10121, 10122 Extra Details: carbonic anhydrase; thermal denaturation; conformational stability;,bovine erythrocytes

Submission Details

ID: 35X8xCNJ4

Submitter: Connie Wang

Submission Date: April 24, 2018, 8:39 p.m.

Version: 1

Publication Details
Lavecchia R;Zugaro M,FEBS Lett. (1991) Thermal denaturation of erythrocyte carbonic anhydrase. PMID:1959599
Additional Information

Structure view and single mutant data analysis

Study data

No weblogo for data of varying length.
Colors: D E R H K S T N Q A V I L M F Y W C G P
 

Data Distribution

Studies with similar sequences (approximate matches)

Correlation with other assays (exact sequence matches)


Relevant PDB Entries

Structure ID Release Date Resolution Structure Title
6QEB 2019-02-06 Assessment of a large enzyme-drug complex by proton-detected solid-state NMR without deuteration
6GCY 2019-02-06 Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (saccharin-sugar conjugate complex)
6FJI 2019-02-06 Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (apo).
5C8I 2016-07-20 Joint X-ray/neutron structure of Human Carbonic Anhydrase II in complex with Methazolamide
6HD2 2019-08-28 Active-site conformational dynamics of carbonic anhydrase II under native conditions: An NMR perspective
6BC9 2018-02-28 Joint X-ray/neutron structure of human carbonic anhydrase II in complex with dorzolamide
6FJJ 2019-02-06 Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (saccharin).
3K34 2010-05-12 0.9 Human carbonic anhydrase II with a sulfonamide inhibitor
6KM2 2020-08-05 0.9 Human Carbonic Anhydrase II V143I variant 15 atm CO2
3KS3 2010-01-26 0.9 High resolution structure of Human Carbonic Anhydrase II at 0.9 A
6B00 2017-12-13 0.9 Thermostabilized mutant of human carbonic anhydrase II - A65T L100H K154N L224S L240P A248T
5Y2S 2018-02-14 0.9 7.0 atm CO2-pressurized human carbonic anhydrase II
6KLZ 2020-08-12 0.9 Human Carbonic Anhydrase II V143I variant 00 atm CO2
6ROB 2020-04-15 0.93 Human Carbonic Anhydrase II in complex with 4-cyanobenzenesulfonamide
6KM0 2020-08-05 0.93 Human Carbonic Anhydrase II V143I variant 07 atm CO2
3U7C 2013-02-13 0.93 crystal structure of the V143I mutant of human carbonic anhydrase II
6SBL 2020-08-26 0.94 Human Carbonic Anhydrase II in complex with 4-hexylbenzenesulfonamide
6ROE 2020-04-15 0.94 Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide
6RH4 2020-04-15 0.95 Human Carbonic Anhydrase II in complex with 4-Nitrobenzenesulfonamide.
6SAY 2020-04-15 0.95 Human Carbonic Anhydrase II in complex with fragment.
6RQI 2020-04-15 0.95 Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide
6SBH 2020-04-08 0.95 Human Carbonic Anhydrase II in complex with 4-pentylbenzenesulfonamide.
6YZN 2020-10-28 0.95 Closo-carborane butyl-sulfonamide in complex with CA IX mimic
6S9Z 2020-04-15 0.95 Expression tag modified N-terminus of human Carbonic Anhydrase II covalently linked to fragment
6SBM 2020-08-26 0.95 Human Carbonic Anhydrase II in complex with 4-(pentyloxy)benzenesulfonamide
1LUG 2003-09-09 0.95 Full Matrix Error Analysis of Carbonic Anhydrase
6RKN 2020-04-15 0.96 Human Carbonic Anhydrase II in complex with a fluorinated Benzenesulfonamide.
4YXI 2016-02-03 0.96 Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (2).
6RFH 2020-05-13 0.97 Human Carbonic Anhydrase II in complex with 4-Carboxybenzenesulfonamide
6T81 2020-10-14 0.98 Human Carbonic anhydrase II bound by 2-Naphthalenesulfonamide.
6SG6 2020-08-26 0.98 Human Carbonic Anhydrase II in complex with furan-containing benzenesulfonamide
4FPT 2013-07-03 0.98 Carbonic Anhydrase II in complex with ethyl (2Z,4R)-2-(sulfamoylimino)-1,3-thiazolidine-4-carboxylate
4FU5 2013-07-17 0.98 Carbonic Anhydrase II in complex with N-[(2Z)-1,3-oxazolidin-2-ylidene]sulfuric diamide
4FRC 2013-07-17 0.98 Carbonic Anhydrase II in complex with N'-sulfamoylpyrrolidine-1-carboximidamide
2FOU 2006-04-04 0.99 Human Carbonic Anhydrase II complexed with two-prong inhibitors
6YZK 2020-10-28 0.99 Carborane closo-pentyl-sulfonamide in complex with CA IX mimic
5OGO 2018-08-01 0.99 Crystal structure of chimeric carbonic anhydrase I with 3-(Benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
6YZU 2020-10-28 1.0 Carborane nido-pentyl-sulfonamide in complex with CA II
6SFQ 2020-08-26 1.0 Atomic resolution structure of human Carbonic Anhydrase II in complex with (R)-5-phenyloxazolidine-2,4-dione
6RIG 2020-05-13 1.0 Human Carbonic Anhydrase II in complex with 4-Hydroxybenzenesulfonamide
5LJT 2017-06-21 1.0 Crystal structure of human carbonic anhydrase II in complex with the 4-((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)benzenesulfonamide inhibitor
4MTY 2013-12-11 1.0 Structure at 1A resolution of a helical aromatic foldamer-protein complex.
6RL9 2020-04-15 1.0 Human Carbonic Anhydrase II in complex with 4-Aminobenzenesulfonamide
5Y2R 2018-02-14 1.0 2.5 atm CO2-pressurized human carbonic anhydrase II
4Q78 2015-03-18 1.0 Structure-assisted design of carborane-based inhibitors of carbonic anhydrase
6RZX 2020-06-03 1.0 Carbonic Anhydrase CAIX mimic in complex with inhibitor FBSA
2NNO 2007-05-08 1.01 Structure of inhibitor binding to Carbonic Anhydrase II
6RIT 2020-04-15 1.01 Human Carbonic Anhydrase II in complex with 2-Fluorobenzenesulfonamide
6G3Q 2018-11-28 1.01 Crystal structure of human carbonic anhydrase II in complex with the inhibitor famotidine
6NJ3 2019-10-02 1.01 Thermostable variant of human carbonic anhydrase with ordered tetrazine 2.0 at site 233
4YX4 2016-02-03 1.01 Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (1).
6SAC 2020-04-15 1.02 N-terminal expression tag remainder of human Carbonic Anhydrase II covalently modified by fragment
6SDJ 2020-04-15 1.02 Human Carbonic Anhydrase II in complex with (R)-1-aminopropan-2-ol
6HR3 2019-10-09 1.02 Human Carbonic Anhydrase II in complex with 4-Propylbenzenesulfonamide
6SDI 2020-08-26 1.03 Human Carbonic Anhydrase II in complex with an inhibitor soaked at a concentration of 0.01 mM
6YZW 2020-10-28 1.03 Carborane closo-hexyl-sulfonamide in complex with CA II
2NNS 2007-05-08 1.03 Structure of inhibitor binding to Carbonic Anhydrase II
5LL8 2017-08-16 1.03 Human Carbonic Anhydrase II in complex with aliphatic Benzenesulfonamide inhibitor.
3V7X 2012-04-04 1.03 Complex of human carbonic anhydrase II with N-[2-(3,4-dimethoxyphenyl)ethyl]-4-sulfamoylbenzamide
6I0W 2019-11-20 1.04 Human Carbonic Anhydrase II in complex with 4-Methoxybenzenesulfonamide
6SFU 2020-08-26 1.04 Human Carbonic Anhydrase II in complex with a furan-containing benzenesulfonamide
6YZQ 2020-10-28 1.04 Carborane closo-butyl-sulfonamide in complex with CA II
6SDH 2020-08-26 1.04 Human Carbonic Anhydrase II in complex with an inhibitor soaked at a concentration of 5 mM
6XXT 2020-06-03 1.05 The crystal structure of hCA II in complex with a 4-(4-aroylpiperazine-1-carbonyl)benzenesulfonamide derivative.
4FVN 2013-07-17 1.05 Carbonic Anhydrase II in complex with N-(tetrahydropyrimidin-2(1H)-ylidene)sulfuric diamide
2ILI 2007-06-05 1.05 Refine atomic structure of human carbonic anhydrase II
6YZT 2020-10-28 1.05 Closo-carborane propyl-sulfonamide in complex with CA II
6SD7 2020-04-15 1.05 Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide and its dimer
5LJQ 2017-06-21 1.05 Crystal structure of human carbonic anhydrase II in complex with the 4-(4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl)benzenesulfonamide inhibitor
6Z04 2020-10-28 1.05 Nido-carborane butyl-sulfonamide in complex with CA IX mimic
5DOH 2016-09-28 1.05 Crystal structure of human carbonic anhydrase isozyme II with 2-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-3,5,6-trifluoro-4-[(2-hydroxyethyl)thio]benzenesulfonamide
6YZS 2020-10-28 1.05 Carborane closo-pentyl-sulfonamide in complex with CA II
6KM1 2020-08-05 1.05 Human Carbonic Anhydrase II V143I variant 13 atm CO2
3VBD 2012-04-04 1.05 Complex of human carbonic anhydrase II with 4-(6-methoxy-3,4-dihydroisoquinolin-1-yl)benzenesulfonamide
4FVO 2013-07-03 1.05 Carbonic Anhydrase II in complex with N-[(2E)-3,4-dihydroquinazolin-2(1H)-ylidene]sulfuric diamide
1MOO 2002-09-18 1.05 Site Specific Mutant (H64A) of Human Carbonic Anhydrase II at high resolution
4YXO 2016-02-03 1.06 Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (3).
6RJJ 2020-04-15 1.06 Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide
4WW6 2015-07-01 1.06 Crystal structure of human carbonic anhydrase isozyme II with 2,3,5,6-Tetrafluoro-4-(propylthio)benzenesulfonamide
4PZH 2015-01-28 1.06 Crystal structure of human carbonic anhydrase isozyme II with 2,3,5,6-tetrafluoro-4[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
6RS5 2020-04-15 1.07 Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide
6RNP 2020-04-15 1.07 Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide
4YYT 2016-02-03 1.07 Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (5).
6I3E 2019-11-20 1.07 Human Carbonic Anhydrase II in complex with 4-Butylbenzenesulfonamide
4Q08 2015-01-28 1.07 Crystal structure of chimeric carbonic anhydrase XII with inhibitor
5M78 2017-12-20 1.08 Human Carbonic Anhydrase II in complex with fragment-like inhibitor.
6GDC 2019-05-01 1.08 Human Carbonic Anhydrase II in complex with Benzenesulfonamide
4YXU 2016-02-03 1.08 Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (4).
6I1U 2019-11-20 1.08 Human Carbonic Anhydrase II in complex with 4-Ethoxybenzenesulfonamide
6SDL 2020-08-26 1.08 Human Carbonic Anhydrase II in complex with (R)-N-(3-(1H-indol-1-yl)-2-methylpropyl)-4-sulfamoylbenzamide
6RG5 2020-05-13 1.09 Human Carbonic Anhydrase II in complex with 4-(2-hydroxyethyl)benzenesulfonamide
6SB7 2020-04-15 1.09 Human Carbonic Anhydrase II in complex with fragment.
6RSZ 2020-04-15 1.09 Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide
6GM9 2019-06-19 1.09 Human Carbonic Anhydrase II in complex with 4-Methylbenzenesulfonamide
6RRI 2020-04-15 1.1 Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide
2WEG 2009-11-10 1.1 Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors
2NNV 2007-05-08 1.1 Structure of inhibitor binding to Carbonic Anhydrase II
4WL4 2015-10-14 1.1 Crystal structure of human carbonic anhydrase II in complex with the 6-hydroxy-chromene-2-thione inhibitor
5NY6 2018-01-17 1.1 Carbonic Anhydrase II Inhibitor RA12
3SAX 2012-04-11 1.1 Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-{[(5-ethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide
6HQX 2019-10-09 1.1 Human Carbonic Anhydrase II in complex with 4-Ethylbenzenesulfonamide
5NY1 2018-01-17 1.1 Carbonic Anhydrase II Inhibitor RA10
6SAS 2020-04-15 1.1 Human Carbonic Anhydrase II in complex with fragment.
5NXW 2018-01-17 1.1 Carbonic Anhydrase II Inhibitor RA9
5DRS 2016-09-28 1.1 Crystal structure of human carbonic anhydraseisozyme II with 3-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
5NXV 2018-01-17 1.1 Carbonic Anhydrase II Inhibitor RA8
3HS4 2009-12-08 1.1 Human carbonic anhydrase II complexed with acetazolamide
3D93 2008-09-02 1.1 Apo Human carbonic anhydrase II bound with substrate carbon dioxide
3D92 2008-09-02 1.1 Human carbonic anhydrase II bound with substrate carbon dioxide
5OGN 2018-08-01 1.1 Metalacarborane inhibitors of Carbonic Anhydrase IX
5LLC 2017-08-16 1.1 Crystal structure of human carbonic anhydrase isozyme II with 3-(Methylamino)-2,5,6-trifluoro-4-[(2-phenylethyl)sulfonyl]benzenesulfonamide
5JGT 2017-01-11 1.1 Human carbonic anhydrase II (F131Y/L198A) complexed with 1,3-thiazole-2-sulfonamide
4YGJ 2015-03-25 1.1 NaBr--Interactions between Hofmeister Anions and the Binding Pocket of a Protein
6YZX 2020-10-28 1.1 Carborane nido-hexyl-sulfonamide in complex with CA II
2FOS 2006-04-04 1.1 Human Carbonic Anhydrase II complexed with two-prong inhibitors
6YKH 2020-09-09 1.1 Metala-Carborane di-ethyl-sulfonamide (cis isomer) in complex with CA IX mimic
5OGP 2018-08-01 1.1 Metalacarborane inhibitors of Carbonic Anhydrase IX
5JGS 2017-01-11 1.11 Human carbonic anhydrase II (F131Y/L198A) complexed with benzo[d]thiazole-2-sulfonamide
5LL4 2017-08-16 1.12 Crystal structure of human carbonic anhydrase isozyme II with 4-(1H-benzimidazol-1-ylacetyl)benzenesulfonamide
6T9Z 2020-06-17 1.12 Nidocarborane inhibitor of Carbonic Anhydrase IX
4Q6D 2014-11-26 1.12 Crystal structure of human carbonic anhydrase isozyme II with 4-[(Z)-azepan-1-yldiazenyl]benzenesulfonamide
6G6T 2019-03-13 1.12 Crystal structure of human carbonic anhydrase isozyme II with N-butyl-2,4-dichloro-5-sulfamoyl-benzamide
4Q6E 2014-11-26 1.12 Crystal structure of human carbonic anhydrase isozyme II with 4-{[3-(3,5-Dimethyl-1H-pyrazol-1-yl)-3-oxopropyl]amino}benzene-1-sulfonamide
5LLG 2017-08-16 1.12 Crystal structure of human carbonic anhydrase isozyme II with 4-Propylthiobenzenesulfonamide
6HXD 2019-10-30 1.12 Human Carbonic Anhydrase II in complex with 4-Butylbenzenesulfonamide
6OTK 2020-05-06 1.12 Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB10-596B
5JEH 2017-01-11 1.13 Human carbonic anhydrase II (L198A) complexed with benzo[d]thiazole-2-sulfonamide
6SG0 2020-08-26 1.13 Atomic resolution structure of Human Carbonic Anhydrase II in complex with furosemide
6T4O 2020-10-14 1.13 Human Carbonic anhydrase II bound by 3,5-dimethylbenzenesulfonamide
5EKJ 2016-01-06 1.13 Human Carbonic Anhydrase II complexed with a two-faced guest
6RRG 2020-04-15 1.13 Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide
6S9G 2020-04-15 1.14 Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide
4RUY 2015-04-22 1.14 Crystal structure of human Carbonic Anhydrase II in complex with 4-propoxybenzenesulfonamide
4RUX 2015-04-22 1.14 Crystal structure of human Carbonic Anhydrase II in complex with 4-(allyloxy)benzenesulfonamide
2NXT 2007-04-24 1.15 Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II
5SZ6 2016-12-28 1.15 Carbonic anhydrase IX-mimic in complex with 4-(3-formylphenyl)-benzenesulfonamide
4Q06 2015-01-28 1.15 Crystal structure of chimeric carbonic anhydrase IX with inhibitor
6IC2 2019-05-15 1.15 Polypharmacology of Epacadostat: a Potent and Selective Inhibitor of the Tumor Associated Carbonic Anhydrases IX and XII
4Q07 2015-01-28 1.15 Crystal structure of chimeric carbonic anhydrase IX with inhibitor
2FOV 2006-04-04 1.15 Human Carbonic Anhydrase II complexed with two-prong inhibitors
4HF3 2013-10-23 1.15 Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
6KM4 2020-08-05 1.15 Human Carbonic Anhydrase II native 07 atm CO2
6YOL 2020-08-19 1.15 Meta-Nidocarborane propyl-sulfonamide in complex with CA IX mimic
6KM6 2020-08-05 1.15 Human Carbonic Anhydrase II native 15 atm CO2
5BYI 2015-08-05 1.15 Human carbonic anhydrase II with an azobenzene inhibitor (1d)
2EU2 2006-07-11 1.15 Human Carbonic Anhydrase II in complex with novel inhibitors
6KM5 2020-08-05 1.15 Human Carbonic Anhydrase II native 13 atm CO2
5JE7 2017-01-11 1.15 Human carbonic anhydrase II (F131Y) complexed with benzo[d]thiazole-2-sulfonamide
6KM3 2020-08-05 1.15 Human Carbonic Anhydrase II native 00 atm CO2
3MHO 2010-10-20 1.15 Crystal structure of human carbonic anhydrase isozyme II with 4-[N-(6-chloro-5-formyl-2-methylthiopyrimidin-4-yl)amino]benzenesulfonamide
4ITO 2014-03-26 1.16 Human CA II inhibition by novel sulfonamide
3RYY 2011-08-10 1.16 Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
5NXI 2018-01-17 1.16 Carbonic Anhydrase II Inhibitor RA2
5MJN 2017-12-06 1.17 Three dimensional structure of human carbonic anhydrase II in complex with 5-[(4Chlorobenzyl)sulfanyl]thiophene-2-sulfonamide
6YO7 2020-08-19 1.17 Ortho-Carborane di-propyl-sulfonamide in complex with CA IX mimic
3M2Y 2011-05-25 1.17 Carbonic Anhydrase II in complex with novel sulfonamide inhibitor
5JG5 2017-01-11 1.19 Human carbonic anhydrase II (V121T/F131Y) complexed with benzo[d]thiazole-2-sulfonamide
5JEG 2017-01-11 1.19 Human carbonic anhydrase II (V121I) complexed with benzo[d]thiazole-2-sulfonamide
5JEP 2017-01-11 1.19 Human carbonic anhydrase II (T199S) complexed with benzo[d]thiazole-2-sulfonamide
6YKC 2020-09-09 1.2 Metala-Carborane di-ethyl-sulfonamide (trans isomer) in complex with CA IX mimic
6T7U 2020-06-17 1.2 Carborane inhibitor of Carbonic Anhydrase IX
5NXG 2018-01-17 1.2 Carbonic Anhydrase II Inhibitor RA1
6B4D 2018-02-07 1.2 Crystal structure of human carbonic anhydrase II in complex with a heteroaryl-pyrazole carboxylic acid derivative.
6YZJ 2020-10-28 1.2 Closo-carborane ethyl-sulfonamide in complex with CA IX mimic
6YOI 2020-08-19 1.2 Meta-Carborane di-propyl-sulfonamide in complex with CA IX mimic
6YZL 2020-10-28 1.2 Closo-carborane methyl-sulfonamide in complex with CA IX mimic
6R6F 2019-12-18 1.2 Crystal structure of human carbonic anhydrase isozyme II with 4-chloro-2-cyclohexylsulfanyl-N-(2-hydroxyethyl)-5-sulfamoyl-benzamide
6LV9 2020-08-19 1.2 Cu- Carbonic Anhydrase II pH 7.8 0 atm CO2
4Q09 2015-01-28 1.2 Crystal structure of chimeric carbonic anhydrase XII with inhibitor
3RYV 2011-08-10 1.2 Carbonic Anhydrase complexed with N-ethyl-4-sulfamoylbenzamide
6LV6 2020-08-19 1.2 Ni- Carbonic Anhydrase II pH 7.8 20 atm CO2
6LUV 2020-08-19 1.2 apo- Carbonic Anhydrase II pH 7.8 20 atm CO2
6I2F 2019-11-20 1.2 Human Carbonic Anhydrase II in complex with 4-Propoxybenzenesulfonamide
6LUZ 2020-08-19 1.2 Zn- Carbonic Anhydrase II pH 11.0 20 atm CO2
6YZR 2020-10-28 1.2 Carborane nido-butyl-sulfonamide in complex with CA II
6LVA 2020-08-19 1.2 Cu- Carbonic Anhydrase II pH 7.8 20 atm CO2
6LV4 2020-08-19 1.2 Co- Carbonic Anhydrase II pH 11.0 20 atm CO2
6LUU 2020-08-19 1.2 apo- Carbonic Anhydrase II pH 7.8 0 atm CO2
5T74 2017-09-06 1.2 Human carboanhydrase F131C_C206S double mutant in complex with 14
6LV5 2020-08-19 1.2 Ni- Carbonic Anhydrase II pH 7.8 0 atm CO2
6LV2 2020-08-19 1.2 Co- Carbonic Anhydrase II pH 7.8 20 atm CO2
6LUW 2020-08-19 1.2 Zn- Carbonic Anhydrase II pH 7.8 0 atm CO2
5YUI 2018-08-01 1.2 CO2 release in human carbonic anhydrase II crystals: reveal histidine 64 and solvent dynamics
3RJ7 2012-02-29 1.2 Human carbonic anhydrase II complexed with its inhibitor rhenium(I)triscarbonyl-cyclopentadienyl-carboxy-4-aminomethylbenzene-sulfonamide
6LV3 2020-08-19 1.2 Co- Carbonic Anhydrase II pH 11.0 0 atm CO2
6LV1 2020-08-19 1.2 Co- Carbonic Anhydrase II pH 7.8 0 atm CO2
6LV8 2020-08-19 1.2 Ni- Carbonic Anhydrase II pH 11.0 20 atm CO2
6YO2 2020-08-19 1.2 Meta-Carborane propyl-sulfonamide in complex with CA IX mimic
6LUX 2020-08-19 1.2 Zn- Carbonic Anhydrase II pH 7.8 20 atm CO2
6LUY 2020-08-19 1.2 Zn- Carbonic Anhydrase II pH 11.0 0 atm CO2
2NNG 2007-05-08 1.2 Structure of inhibitor binding to Carbonic Anhydrase II
5NXO 2018-01-17 1.2 Carbonic Anhydrase II Inhibitor RA6
6QFW 2019-04-17 1.2 Human carbonic anhydrase II with bound IrCp* complex (cofactor 9) to generate an artificial transfer hydrogenase (ATHase)
5NYA 2018-01-17 1.2 Carbonic Anhydrase II Inhibitor RA13
6LV7 2020-08-19 1.2 Ni- Carbonic Anhydrase II pH 11.0 0 atm CO2
4FIK 2012-06-27 1.2 Human carbonic anhydrase II H64A complexed with thioxolone hydrolysis products
6D1M 2018-06-13 1.21 Design, synthesis, and X-ray of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects
5JES 2017-01-11 1.21 Human carbonic anhydrase II (V121T) complexed with benzo[d]thiazole-2-sulfonamide
5EHV 2016-03-09 1.21 human carbonic anhydrase II in complex with ligand
5U0F 2017-08-30 1.21 Identification of a New Zinc Binding Chemotype by Fragment Screening
5TXY 2017-08-30 1.21 Identification of a New Zinc Binding Chemotype of by Fragment Screening on human carbonic anhydrase
5JG3 2017-01-11 1.21 Human carbonic anhydrase II (121T/N67Q) complexed with benzo[d]thiazole-2-sulfonamide
5EH5 2016-03-09 1.21 human carbonic anhydrase II in complex with ligand
6T5C 2020-10-14 1.22 Human Carbonic anhydrase II bound by anthracene-9-sulfonamide
3L14 2011-01-05 1.22 Human Carbonic Anhydrase II complexed with Althiazide
6RMP 2020-04-15 1.22 Human Carbonic Anhydrase II in complex with fragment.
6PDV 2020-03-11 1.23 Cu-Carbonic Anhydrase II, A Nitrite Reductase
6SEY 2020-08-26 1.23 Human Carbonic Anhydrase II in complex with aliphatically substituted benzenesulfonamide
4YGN 2015-03-25 1.23 NaI--Interactions between Hofmeister Anions and the Binding Pocket of a Protein
4CNX 2015-02-04 1.23 Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture
6NJ5 2019-10-02 1.25 Thermostable variant of human carbonic anhydrase II with disordered tetrazine 2.0 at site 233
3S71 2011-10-19 1.25 The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
5NXP 2018-01-17 1.25 Carbonic Anhydrase II Inhibitor RA7
2FOQ 2006-02-28 1.25 Human Carbonic Anhydrase II complexed with two-prong inhibitors
6RG4 2020-05-13 1.25 Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(2-benzyl-4-methylpiperazin-1-yl)benzenesulfonamide
6YOK 2020-08-19 1.25 Para-Carborane di-propyl-sulfonamide in complex with CA IX mimic
5YUJ 2018-08-01 1.25 CO2 release in human carbonic anhydrase II crystals: reveal histidine 64 and solvent dynamics
5NXM 2018-05-30 1.25 Carbonic Anhydrase II Inhibitor RA1
6SDS 2020-06-10 1.26 HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A SULFONAMIDE INHIBITOR
5WEX 2017-10-11 1.26 Discovery of new selenoureido analogs of 4-(4-fluorophenylureido) benzenesulfonamides as carbonic anhydrase inhibitors
6OUD 2020-05-06 1.26 Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB11-694B
3GZ0 2009-07-21 1.26 Apo-human carbonic anhydrase II revisited: Implications of the loss of a metal in protein structure, stability and solvent network
4Z1J 2015-08-26 1.27 Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)
5U0E 2017-08-30 1.27 Identification of a New Zinc Binding Chemotype by Fragment Screening
5SZ5 2016-12-28 1.27 Carbonic anhydrase IX-mimic in complex with 4-(2-methylphenyl)-benzenesulfonamide
6C7W 2018-05-23 1.28 Carbonic anhydrase 2 in complex with [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDRO-2-FURANYL]METHYL SULFAMATE inhibitor
5G0C 2016-05-25 1.28 An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C
7JNZ 2020-11-04 1.29 Carbonic Anhydrase II Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)cyclohexanecarboxamide
7JNX 2020-11-04 1.29 Carbonic Anhydrase II Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)pivalamide
7JNW 2020-11-04 1.29 Carbonic Anhydrase II Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)isobutyramide
3S9T 2012-04-18 1.3 Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-{[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide
6UGQ 2019-12-18 1.3 Human Carbonic Anhydrase IX-mimic complexed with SB4-206
6NJ4 2019-10-02 1.3 Thermostable variant of human carbonic anhydrase with disordered tetrazine 2.0 reacted with strained trans-cyclooctene at site 233
6WQ9 2020-06-24 1.3 Carbonic Anhydrase II Complexed with 3-((2-((Naphthalen-2-ylmethyl)(4-sulfamoylphenethyl)amino)-2-oxoethyl)(phenethyl)amino)propanoic acid
5T72 2017-09-06 1.3 Human carboanhydrase F131C_C206S double mutant in complex with 2
6WQ7 2020-06-24 1.3 Carbonic Anhydrase II Complexed with 2-((3-Aminopropyl)(phenethyl)amino)-N-(4-fluorobenzyl)-N-(4-sulfamoylphenethyl)acetamide
3S8X 2012-04-11 1.3 Crystal structure of human carbonic anhydrase isozyme II with 4-{[(4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide
6QL2 2019-09-25 1.3 Crystal structure of chimeric carbonic anhydrase VI with ethoxzolamide.
6SYS 2020-10-14 1.3 Crystal structure of (3aR,4S,9bS)-4-(4-hydroxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide with carbonic anhydrase 2
4RH2 2015-11-11 1.3 Crystal structure of human carbonic anhydrase II in complex with 2-(6-hydroxy-3-Oxo-3H-xanthen-9-yl)-5-{3-1-(4-sulfamoyl-phenyl)-1h-[1,2,3]triazol-4-ylmethyl-thioureido}-benzoic acid
5T71 2017-09-06 1.3 Human carboanhydrase F131C_C206S double mutant in complex with SA-2
6GXE 2019-05-08 1.3 Carbonic Anhydrase CAIX mimic in complex with inhibitor JS14
5NEA 2017-12-06 1.3 Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(2-methyl-1,3-oxazol-5-yl)benzene-1-sulfonammide
6WQ5 2020-06-24 1.3 Carbonic Anhydrase II Complexed with 2-((3-Aminopropyl)(phenethyl)amino)-N-(furan-2-ylmethyl)-N-(4-sulfamoylphenethyl)acetamide
5DSR 2016-05-04 1.3 Structure of CO2 released apo-form of human carbonic anhydrase II with 10 min warming
5E28 2016-01-20 1.3 Crystal structure of human carbonic anhydrase II in complex with the 4-(4-aminophenyl)benzenesulfonamide inhibitor
5N1S 2017-12-27 1.3 Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(1H-Indol-2-yl)-benzenesulfonamide
5N1R 2017-12-27 1.3 Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4'-Pyrazol-1-ylmethyl-biphenyl-4-sulfonamide
4QIY 2015-04-15 1.3 Crystal structure of human carbonic anhydrase isozyme II with inhibitor
3PYK 2011-07-13 1.3 Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor
5DSK 2016-05-04 1.3 Structure of CO2 released holo-form of human carbonic anhydrase II with 3 min warming
6OE0 2019-06-12 1.3 Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects
5DSM 2016-05-04 1.3 Structure of CO2 released holo-form of human carbonic anhydrase II with 25 min warming
6ODZ 2019-06-12 1.3 Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects
6UGP 2019-12-18 1.31 Human Carbonic Anhydrase 2 complexed with SB4-206
6OTM 2020-05-06 1.31 Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB10-586B
6H3Q 2019-07-17 1.31 Crystal structure of human carbonic anhydrase II in complex with the 4-(5-(chloromethyl)-1,3-selenazol-2-yl)benzenesulfonamide
6UGR 2019-12-18 1.31 Human Carbonic Anhydrase 2 complexed with SB4-208
6UH0 2019-12-18 1.31 Human Carbonic Anhydrase 2 in complex with SB4-202
7JO2 2020-11-04 1.31 Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)isobutyramide
6UGZ 2019-12-18 1.31 Human Carbonic Anhydrase IX-mimic complexed with SB4-208
3ZP9 2013-10-30 1.31 Human Carbonic Anhydrase II as a Scaffold for an Artificial Transfer Hydrogenase
6U4Q 2020-01-22 1.31 Carbonic anhydrase 2 in complex with SB4197
6QFX 2019-04-17 1.32 Human carbonic anhydrase II with bound IrCp* complex (cofactor 10) to generate an artificial transfer hydrogenase (ATHase)
5ZXW 2018-06-13 1.32 Crystal structure of human carbonic anhydrase II crystallized by ammonium sulfate
6RG3 2020-05-13 1.32 Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(2-benzylpiperazin-1-yl)benzenesulfonamide
5THN 2017-04-26 1.33 Crystal Structure of 2-Hydroxycyclohepta-2,4,6-triene-1-thione bound to human carbonic anhydrase 2
5EKM 2016-01-06 1.33 Human Carbonic Anhydrase II complexed with a two-faced guest
6UFC 2020-08-05 1.33 Carbonic anhydrase 2 with inhibitor (2Z)-2-[(4-methoxyphenyl)methylidene]-3-oxo-N-(4-sulfamoylphenyl)butanamide (11d/D4)
4HEZ 2013-10-23 1.34 Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
5JDV 2017-01-11 1.34 Human carbonic anhydrase II (F131W) complexed with benzo[d]thiazole-2-sulfonamide
5EKH 2016-01-06 1.34 Human Carbonic Anhydrase II complexed with a two-faced guest
4Z1K 2015-08-26 1.35 Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)
5ULN 2017-10-11 1.35 Synthesis of novel seleno ureido containing compounds as SLC-0111 analogs. Investigations on carbonic anhydrases activity, glutathione peroxidase and X-ray crystallography
4KUV 2014-06-25 1.35 Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(4-chlorophenylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor
3KNE 2011-05-18 1.35 Carbonic Anhydrase II H64C mutant in complex with an in situ formed triazole
6GXB 2019-05-08 1.35 Carbonic Anhydrase CAIX mimic in complex with inhibitor JS13
6YZP 2020-10-28 1.35 Carborane nido-hexyl-sulfonamide in complex with CA IX mimic
6VJ3 2020-03-11 1.35 Carbonic Anhydrase II in complex with pyrimidine-based inhibitor
4BF1 2014-01-22 1.35 Three dimensional structure of human carbonic anhydrase II in complex with 5-(1-naphthalen-1-yl-1,2,3-triazol-4-yl)thiophene-2-sulfonamide
4MDG 2014-01-01 1.35 Closo Carborane Carbonic Anhydrase Inhibitor
3M1K 2010-11-17 1.35 Carbonic Anhydrase in complex with fragment
6QL3 2019-09-25 1.35 Crystal structure of chimeric carbonic anhydrase VI with 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
4QK3 2015-03-04 1.35 Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - [delta]230-240
5G03 2016-05-25 1.35 An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C
3MYQ 2011-02-02 1.35 Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-[(1H-imidazo[4,5-c]quinolin-2-ylsulfanyl)acetyl]benzenesulfonamide
6WQ4 2020-06-24 1.35 Carbonic Anhydrase II Complexed with 2-((2-Cyanoethyl)(phenethyl)amino)-N-phenethyl-N-(4-sulfamoylphenethyl)acetamide
6PEA 2020-03-11 1.36 High Resolution Apo Carbonic Anhydrase II
6OUF 2020-05-06 1.36 Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB11-707A
6UX1 2020-04-22 1.36 Carbonic Anhydrase II Complexed with Salicylic Acid
6PGX 2019-08-21 1.36 Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity
5AML 2015-04-08 1.36 Three dimensional structure of human carbonic anhydrase II in complex with 2-(But-2-yn-1-ylsulfamoyl)-4-sulfamoylbenzoic acid
6U4T 2020-01-22 1.36 Carbonic anhydrase 9 in complex with SB4197
5JQT 2016-10-19 1.36 Crystal structure of human carbonic anhydrase II in complex with Benzoxaborole at pH 7.4
3RYZ 2011-08-10 1.37 Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
6VKG 2020-03-04 1.37 Human carbonic anhydrase IX mimic with Epacadostat bound
7JOB 2020-11-04 1.38 Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)cyclohexanecarboxamide
7JOC 2020-11-04 1.38 Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)adamantanecarboxamide
5EH8 2016-03-09 1.38 human carbonic anhydrase II in complex with ligand
3M1W 2011-05-25 1.38 Carbonic Anhyrdase II mutant W5CH64C with closed disulfide bond in complex with sulfate
3M14 2011-05-25 1.38 Carbonic Anhydrase II in complex with novel sulfonamide inhibitor
6S03 2020-06-03 1.38 Carbonic Anhydrase CAIX mimic in complex with inhibitor I39LT379
3RYJ 2011-08-10 1.39 Carbonic Anhydrase complexed with 4-sulfamoyl-N-(2,2,2-trifluoroethyl)benzamide
5VGY 2017-08-30 1.39 Identification of a New Zinc Binding Chemotype by Fragment Screening
5EHW 2016-03-09 1.39 human carbonic anhydrase II in complex with ligand
5WLU 2018-08-01 1.39 Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide
3KIG 2010-11-17 1.39 Mutant carbonic anhydrase II in complex with an azide and an alkyne
6T4N 2020-10-14 1.4 Human Carbonic anhydrase II bound by 2,4,6-trimethylbenzenesulfonamide
5NY3 2018-01-17 1.4 Carbonic Anhydrase II Inhibitor RA11
2WEO 2009-11-10 1.4 Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors
5G01 2016-05-25 1.4 An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C
5JQ0 2016-10-19 1.4 Crystal structure of human carbonic anhydrase II in complex with Benzoxaborole at pH=8.7
3M04 2011-05-25 1.4 Carbonic Anhydrase II in complex with novel sulfonamide inhibitor
2QO8 2008-01-22 1.4 Crystal structure of the complex of hcaii with an indane-sulfonamide inhibitor
5BRW 2015-06-17 1.4 Catalytic Improvement of an Artificial Metalloenzyme by Computational Design
3SBI 2012-04-11 1.4 Crystal structure of human carbonic anhydrase isozyme II with 4-[(2-pyrimidinylsulfanyl)acetyl]benzenesulfonamide
4QSB 2015-01-21 1.4 Crystal structure of human carbonic anhydrase isozyme II with 3-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}benzenesulfonamide
3S74 2011-10-19 1.4 The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
5WLV 2018-08-01 1.4 Carbonic Anhydrase II in complex with aryloxy-2-hydroxypropylammine sulfonamide
6D1L 2018-06-13 1.4 Design, synthesis, and X-ray of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects
3M96 2011-02-02 1.4 Crystal structure of human carbonic anhydrase isozyme II with 5-{[(5-bromo-1H-benzimidazol-2-yl)sulfanyl]acetyl}-2-chlorobenzenesulfonamide
3MWO 2010-06-09 1.4 Human carbonic anhydrase II in a doubled monoclinic cell: a re-determination
5DSP 2016-05-04 1.4 Structure of CO2 released apo-form of human carbonic anhydrase II with 40 sec warming
5E2K 2016-01-20 1.4 Crystal structure of human carbonic anhydrase II in complex with the 4-(3-aminophenyl)benzenesulfonamide inhibitor
6WQ8 2020-06-24 1.4 Carbonic Anhydrase II Complexed with 3-((2-((Furan-2-ylmethyl)(4-sulfamoylphenethyl)amino)-2-oxoethyl)(phenethyl)amino)propanoic acid
5N25 2017-12-27 1.4 Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-Pyridin-3-yl-benzenesulfonamide
5DSO 2016-05-04 1.4 Structure of CO2 bound apo-form of human carbonic anhydrase II with 0 sec (no) warming
3M5S 2011-05-25 1.4 Carbonic Anhydrase II mutant H64C in complex with carbonate
6UGN 2019-12-18 1.41 Human Carbonic Anhydrase 2 complexed with SB4-205
6OUE 2020-05-06 1.41 Carbonic Anhydrase II complexed with benzene sulfonamide MB11-707A
3IBU 2009-09-22 1.41 The crystal structure of the human carbonic anhydrase II in complex with an aliphatic sulfamate inhibitor
5LVS 2017-03-08 1.42 Self-assembled protein-aromatic foldamer complexes with 2:3 and 2:2:1 stoichiometries
5EH7 2016-03-09 1.42 human carbonic anhydrase II in complex with ligand
5TI0 2017-04-26 1.42 Crystal Structure of 2-Hydroxycyclohepta-2,4,6-triene-1-thione bound to human carbonic anhydrase 2 L198G
6QL1 2019-09-25 1.42 Crystal structure of chimeric carbonic anhydrase VI with 4-[(4,6-dimethylpyrimidin-2-yl)thio]-2,3,5,6-tetrafluorobenzenesulfonamide
6OUB 2020-05-06 1.42 Carbonic Anhydrase II complexed with benzene sulfonamide MB11-694B
6SX9 2020-10-07 1.43 Crystal structure of carbonic anhydrase 2 with 4-(2-chlorophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
6CEH 2018-05-23 1.43 Design, Synthesis, X-ray and Biological Activities of Selenides Bearing the Benzenesulfonamide Moiety as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology
6RHK 2020-05-13 1.44 The crystal structure of human carbonic anhydrase II in complex with 4-(3-benzylimidazolidine-1-carbonyl)benzenesulfonamide
6HX5 2018-12-26 1.44 Selenols: a new class of Carbonic Anhydrase inhibitors
6NM0 2020-01-15 1.44 Selective inhibition of carbonic anhydrase IX activity, using compound SLC-149, displays limited anticancer effects in breast cancer cell lines
7JNR 2020-11-04 1.44 Carbonic Anhydrase II Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)propionamide
3HLJ 2010-03-02 1.44 Crystal structure of human carbonic anhydrase isozyme II with 3-methylthiobenzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonamide
6RHJ 2020-05-13 1.44 Crystal structure of human carbonic anhydrase isozyme II with 4-(4-benzyl-1,4-diazepane-1-carbonyl)benzenesulfonamide
5TY8 2017-08-30 1.45 Identification of a New Zinc Binding Chemotype by Fragment Screening
5WG7 2018-02-07 1.45 Human Carbonic Anhydrase II complexed with AceK
5YUK 2018-08-01 1.45 CO2 release in human carbonic anhydrase II crystals: reveal histidine 64 and solvent dynamics
7JO3 2020-11-04 1.45 Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)pivalamide
4Q8Y 2015-03-11 1.45 Crystal structure of 2-hydroxyisoquinoline-1(2H)-thione bound to human carbonic anhydrase II
6OUH 2020-05-06 1.45 Carbonic Anhydrase II mimic complexed with benzene sulfonamide MB11-710A
4E49 2012-06-27 1.45 Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
4YWP 2015-10-14 1.45 Sucrose Binding Site in genetically engineered Carbonic anhydrase IX
2WEJ 2009-11-10 1.45 Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors
3OKV 2011-07-06 1.45 Human Carbonic Anhydrase II A65S, N67Q (CA IX mimic) bound with 2-Ethylestrone 3-O-sulfamate
6QFV 2019-04-17 1.45 Human carbonic anhydrase II with bound IrCp* complex (cofactor 8) to generate an artificial transfer hydrogenase (ATHase)
4HEY 2013-10-23 1.45 Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
4Q7W 2015-03-11 1.45 Crystal structure of 1-hydroxy-6-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II
4Z0Q 2015-08-26 1.45 Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)
3OIM 2011-07-06 1.45 Human Carbonic anhydrase II bound by 2-Ethylestradiol 3-O-sulfamate
2QP6 2008-06-03 1.45 The crystal structure of the complex of hcaII with a bioreductive antitumor derivative
4CQ0 2014-04-16 1.45 Cyclic secondary sulfonamides: unusually good inhibitors of cancer- related carbonic anhydrase enzymes
4E4A 2012-06-27 1.45 Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
4YVY 2016-03-30 1.45 Crystal structure of human carbonic anhydrase II in complex with hydroxylamine-O-sulfonamide, a molecule incorporating two zinc-binding groups.
4KAP 2013-07-10 1.45 The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand
6H6S 2019-01-09 1.45 Sad phasing on nickel-substituted human carbonic anhydrase II
6OE1 2019-06-12 1.45 Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects
5DSL 2016-05-04 1.45 Structure of CO2 released holo-form of human carbonic anhydrase II with 10 min warming
3OKU 2011-07-06 1.45 Human Carbonic Anhydrase II in complex with 2-Ethylestrone-3-O-sulfamate
6H29 2018-09-05 1.46 HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BENZYL CARBAMATE
6UGO 2019-12-18 1.46 Human Carbonic Anhydrase IX-mimic complexed with SB4-205
2AW1 2006-07-04 1.46 Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor Celecoxib
2GD8 2007-02-06 1.46 Crystal structure analysis of the human carbonic anhydrase II in complex with a 2-substituted estradiol bis-sulfamate
4QEF 2014-10-08 1.47 Human Carbonic Anhydrase II V207I - cyanate inhibitor complex
3QYK 2012-03-07 1.47 Human Carbonic Anhydrase II complexed with triple ring benzene sulfonamide inhibitor
3PO6 2011-04-06 1.47 Crystal structure of human carbonic anhydrase II with 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide
5TH4 2017-04-26 1.47 Crystal Structure of 1-hydroxypyridine-2(1H)-thione bound to human carbonic anhydrase 2 L198G
6OUJ 2020-05-06 1.47 Carbonic Anhydrase II complexed with benzene sulfonamide MB11-689A
6OTP 2020-05-06 1.47 Carbonic Anhydrase II complexed with ureic benzene sulfonamide MB10-586B
4Z1N 2015-08-26 1.47 Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)
6OTQ 2020-05-06 1.47 Carbonic Anhydrase II complexed with ureic benzene sulfonamide MB10-596B
3V2M 2012-12-26 1.47 Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II
3OYQ 2011-08-10 1.47 Structure of Human Carbonic Anhydrase II complexed with 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE
6UFD 2020-08-05 1.48 Carbonic anhydrase 2 with inhibitor (2Z)-3-oxo-N-(4-sulfamoylphenyl)-2-[(thiophen-2-yl)methylidene]butanamide (11g/D7)
3DD0 2009-03-03 1.48 Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
6YQU 2020-07-01 1.48 CRYSTAL STRUCTURE OF HUMAN CA II IN COMPLEX WITH 2-MERCAPTOBENZOXAZOLE
7JNV 2020-11-04 1.49 Carbonic Anhydrase II Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)butyramide
4DZ9 2013-03-27 1.49 hCA II in complex with novel sulfonamide inhibitors Set D
2WD2 2010-03-31 1.49 A chimeric microtubule disruptor with efficacy on a taxane resistant cell line
5WLR 2018-08-01 1.49 Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide
3P58 2011-10-19 1.49 Human Carbonic Anhydrase in complex with Benzyl (Methyl) Carbamodithoic Acid
4DZ7 2013-03-27 1.49 hCA II in complex with novel sulfonamide inhibitors Set D
3P5A 2011-10-19 1.49 Human Carbonic Anhydrase complexed with Sodium morpholinocarbodithioate
3DCW 2009-03-03 1.5 Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
3OIL 2011-07-06 1.5 Human Carbonic anhydrase II mutant A65S, N67Q (CA IX mimic) bound by 2-Ethylestradiol 3-O-sulfamate
1OQ5 2004-03-23 1.5 CARBONIC ANHYDRASE II IN COMPLEX WITH NANOMOLAR INHIBITOR
4E3F 2012-06-27 1.5 Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
6OTO 2020-05-06 1.5 Carbonic Anhydrase II complexed with ureic benzene sulfonamide MB9-561B
3N3J 2011-03-09 1.5 Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor
3KOK 2010-08-25 1.5 Crystal structure of cobalt (II) human carbonic anhydrase II at pH 8.5
3KON 2010-08-25 1.5 Crystal structure of cobalt (II) human carbonic anhydrase II at pH 11.0
6YZO 2020-10-28 1.5 Carborane closo-hexyl-sulfonamide in complex with CA IX mimic
3TVN 2012-08-08 1.5 Human Carbonic Anhydrase II Proton Transfer Mutant
5T75 2017-09-06 1.5 Human carbonic anhydrase II G132C_C206S double mutant in complex with SA-2
4E3H 2012-06-27 1.5 Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
3M98 2011-03-02 1.5 Crystal structure of human carbonic anhydrase isozyme II with 5-(1H-benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide
5N24 2017-12-27 1.5 Crystal structure of human carbonic anhydrase II in complex with the inhibitor b4'-Cyano-biphenyl-4-sulfonic acid amide
4Q8Z 2015-03-11 1.5 Crystal structure of 1-hydroxy-4-methylpyridin-2(1H)-one bound to human carbonic anhydrase II
5TYA 2017-08-30 1.5 Identification of a New Zinc Binding Chemotype by Fragment Screening
5EHE 2016-11-09 1.5 Crystal structure of human carbonic anhydrase isozyme II with 3-(benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
3S75 2011-10-19 1.5 The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
4ZX1 2015-10-28 1.5 Engineered Carbonic Anhydrase IX mimic in complex with a glucosyl sulfamate inhibitor
4R5B 2014-10-15 1.5 Human Carbonic Anhydrase II in Complex with a Carbohydrate-Based Sulfamate
4BCW 2013-02-06 1.5 Carbonic anhydrase IX mimic in complex with (E)-2-(5-bromo-2- hydroxyphenyl)ethenesulfonic acid
4YGK 2015-03-25 1.5 NaSCN--Interactions between Hofmeister Anions and the Binding Pocket of a Protein
1FR7 2001-01-17 1.5 X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT
4ZWY 2015-08-05 1.5 Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor
3MZC 2011-03-09 1.5 Human carbonic ahydrase II in complex with a benzenesulfonamide inhibitor
5AMD 2015-04-08 1.5 Three dimensional structure of human carbonic anhydrase II in complex with 2-((2-Phenylethyl)sulfamoyl)-4-sulfamoylbenzoic acid
2AX2 2006-01-03 1.5 Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II
3V5G 2012-07-25 1.5 Crystal structure of human carbonic anhydrase II in complex with the 4-sulfamido-benzenesulfonamide inhibitor
4QSA 2015-01-21 1.5 Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-4-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}benzenesulfonamide
4QY3 2014-12-03 1.5 THE CRYSTAL STRUCTURE OF THE COMPLEX of HCAII WITH AN ORTHO-SUBSTITUTED BENZOIC ACID
6MBY 2019-03-13 1.5 Carbonic Anhydrase II in complex with Ferulic Acid
3MNA 2011-04-20 1.5 The crystal structure of human carbonic anhydrase Ii in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor
5THI 2017-04-26 1.5 Crystal Structure of 2-hydroxycyclohepta-2,4,6-trien-1-one bound to human carbonic anhydrase 2 L198G
5TFX 2017-08-09 1.5 New method for synthesis of benzoxazole amide inhibitors of carbonic anhydrase
3P3H 2011-09-21 1.5 Human carbonic anhydrase II in complex with p-(5-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide
3N0N 2011-03-16 1.5 Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor
6ROF 2020-06-03 1.5 Human Carbonic anhydrase II mutant T199V bound by 2-(cyclooctylamino)-3,5,6-trifluoro-4-[(2-hydroxyethyl)thio]benzenesulfonamide
6YZM 2020-10-28 1.5 Carborane nido-pentyl-sulfonamide in complex with CA IX mimic
3MMF 2011-04-20 1.5 Crystal structure of human carbonic anhydrase II in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor
4Q99 2015-03-11 1.5 Crystal structure of 2-mercapto-4-methylphenol bound to human carbonic anhydrase II
6NJ2 2019-10-02 1.5 thermostable carbonic anhydrase II variant with tetrazine 2.0 at site 186
3RG4 2012-02-22 1.5 Crystal structure of the W5F mutant of human carbonic anhydrase II
4GL1 2013-09-04 1.5 Structure of H64A/N62L/N67L Human Carbonic Anhydrase II triple mutant
6UZU 2020-10-21 1.5 Carbonic Anhydrase IX-mimic In Complex WITH U-CH3
3OIK 2011-07-06 1.5 Human Carbonic anhydrase II mutant A65S, N67Q (CA IX mimic) bound by 2-Ethylestradiol 3,17-O,O-bis-sulfamate
3MHM 2010-10-20 1.5 Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-benzylamino-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide
5E2S 2016-01-20 1.5 Crystal structure of human carbonic anhydrase II in complex with the 4-(2-iso-propylphenyl)benzenesulfonamide inhibitor
4JSA 2013-06-19 1.5 Benzenesulfonamide complexed with hCAII H94D
3P5L 2011-10-19 1.5 Human Carbonic Anhydrase complexed with sodium 4-cyano-4-phenylpiperidine-1-carbodithioate
5THJ 2017-04-26 1.5 Crystal Structure of 2-hydroxycyclohepta-2,4,6-trien-1-one bound to human carbonic anhydrase 2
7JO1 2020-11-04 1.5 Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)butyramide
6YQT 2020-07-01 1.5 CRYSTAL STRUCTURE OF HUMAN CA II IN COMPLEX WITH A SULFONAMIDE DERIVATIVE OF 2-MERCAPTOBENZOXAZOLE
5DSQ 2016-05-04 1.5 Structure of CO2 released apo-form of human carbonic anhydrase II with 3 min warming
6C7X 2018-05-23 1.5 Carbonic anhydrase 2 in complex with 2-chloro-5'-O-sulfamoyladenosine
3RLD 2012-02-08 1.5 Crystal structure of the Y7I mutant of human carbonic anhydrase II
4JSS 2013-06-19 1.5 Human carbonic anhydrase II H94D bound to a bidentate inhibitor
6OUK 2020-05-06 1.5 Carbonic Anhydrase II complexed with benzene sulfonamide MB10-580B
6RMY 2020-06-03 1.5 Human Carbonic anhydrase II mutant T199V bound by 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
3RZ1 2011-08-10 1.51 Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
4YGL 2015-03-25 1.51 NaClO4--Interactions between Hofmeister Anions and the Binding Pocket of a Protein
5JN7 2017-05-03 1.52 Carbonic Anhydrase II In Complex WITH U-CH3
4QK2 2015-03-04 1.52 Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - E234P
4MDL 2014-01-01 1.52 Meta Carborane Carbonic Anhydrase Inhibitor
6OUI 2020-05-06 1.53 Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB11-710A
4RN4 2015-01-28 1.53 Human Carbonic anhydrases II in complex with a acetazolamide derivative comprising one hydrophobic and one hydrophilic tail moiety
5WGP 2018-02-07 1.53 Human Carbonic Anhydrase IX-mimic complexed with AceK
5TY9 2017-08-30 1.53 Identification of a New Zinc Binding Chemotype by Fragment Screening
4Q90 2015-03-11 1.54 Crystal structure of 4-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II
5U0G 2017-08-30 1.54 Identification of a New Zinc Binding Chemotype by Fragment Screening
2CBA 1993-10-31 1.54 STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES
5EZT 2016-07-20 1.54 Peracetylated Bovine Carbonic Anhydrase II
3OYS 2011-08-10 1.54 Human Carbonic Anhydrase II complexed with 2-{[4-AMINO-3-(3-HYDROXYPROP-1-YN-1-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL]METHYL}-5-METHYL-3-(2-METHYLPHENYL)QUINAZOLIN-4(3H)-ONE
4N16 2014-06-18 1.54 Structure of cholate bound to human carbonic anhydrase II
4JS6 2013-06-19 1.55 Crystal structure of inhibitor-free hCAII H94D
3U3A 2012-10-10 1.55 structure of Human Carbonic Anhydrase II V143I
5AMG 2015-04-08 1.55 Three dimensional structure of human carbonic anhydrase II in complex with 2-(Pentylsulfamoyl)-4-sulfamoylbenzoic acid
4Q9Y 2015-03-11 1.55 Crystal structure of 3-methylthiophenol bound to human carbonic anhydrase II
4E3G 2012-06-27 1.55 Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
4MDM 2014-01-01 1.55 Nido-Carborane Carbonic Anhydrase Inhibitor
2HNC 2006-12-19 1.55 Crystal structure of the human carbonic anhydrase II in complex with the 5-amino-1,3,4-thiadiazole-2-sulfonamide inhibitor.
4Q81 2015-03-11 1.55 Crystal structure of 1-hydroxy-4,6-dimethylpyridine-2(1H)-thione bound to human carbonic anhydrase II
4Q87 2015-03-11 1.55 Crystal structure of 1-hydroxy-4-(trifluoromethyl)pyridine-2(1H)-thione bound to human carbonic anhydrase II
1ZFQ 2006-05-23 1.55 carbonic anhydrase II in complex with ethoxzolamidphenole as sulfonamide inhibitor
5SZ1 2016-12-21 1.55 Carbonic anhydrase II in complex with 4-(2-methylphenyl)-benzenesulfonamide
4KUW 2014-06-25 1.55 Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(4-fluorophenylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor
3IBL 2009-09-22 1.55 The crystal structure of the human carbonic anhydrase II in complex with an aliphatic bis-sulfamate inhibitor
6YJ3 2020-09-09 1.55 Metala-Carborane di-propyl-sulfonamide
5CLU 2015-11-11 1.55 THE CRYSTAL STRUCTURE OF THE COMPLEX of HCAII WITH A SACCHARINE DERIVATIVE
6R6J 2020-04-08 1.55 Crystal structure of human carbonic anhydrase isozyme II with 2-(benzenesulfonyl)-4-chloro-N-(2-hydroxyethyl)-5-sulfamoyl-benzamide
2HL4 2007-05-22 1.55 Crystal structure analysis of human carbonic anhydrase II in complex with a benzenesulfonamide derivative
4Q83 2015-03-11 1.55 Crystal structure of 1-hydroxy-3-(trifluoromethyl)pyridine-2(1H)-thione bound to human carbonic anhydrase II
4KV0 2014-06-25 1.55 Crystal structure of human carbonic anhydrase II in complex with the 5-(3-tosylureido)pyridine-2-sulfonamide inhibitor
6H34 2018-12-19 1.55 The crystal structure of human carbonic anhydrase II in complex with 4-[(4-fluorophenyl)methyl]-1-piperazinyl]benzenesulfonamide.
4Q8X 2015-03-11 1.55 Crystal structure of 1-hydroxy-5-(trifluoromethyl)pyridine-2(1H)-thione bound to human carbonic anhydrase II
5G0B 2016-05-25 1.55 An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C
6CJV 2018-08-08 1.55 Carbonic anhydrase IX-mimic in complex with sucralose
6GOT 2018-10-03 1.56 Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(phenethylthio)benzenesulfonamide
6OUM 2020-05-06 1.56 Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB10-580B
3V3G 2012-06-20 1.56 Kinetic and structural studies of thermostabilized mutants of HCA II.
1ZFK 2006-05-23 1.56 carbonic anhydrase II in complex with N-4-sulfonamidphenyl-N'-4-methylbenzosulfonylurease as sulfonamide inhibitor
2VVA 2009-07-14 1.56 Human carbonic anhydrase in complex with CO2
5WLT 2018-08-01 1.57 Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide
5A6H 2016-05-25 1.57 Synthesis, carbonic anhydrase inhibition and protein X-ray structure of the unusual natural product primary sulfonamide Psammaplin C
6RVK 2019-08-28 1.58 Crystal structure of hCA II in complex with Urea, N-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-N'-(phenylmethyl)-
6H33 2018-12-19 1.58 The crystal structure of human carbonic anhydrase II in complex with 4-(4-phenyl)-4-hydroxy-1-piperidine-1-carbonyl)benzenesulfonamide.
5FNK 2016-03-02 1.59 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
5FNL 2016-09-28 1.59 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
5U0D 2017-08-30 1.59 Identification of a New Zinc Binding Chemotype by Fragment Screening
5FNM 2016-03-02 1.59 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
4K13 2014-04-09 1.6 Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with dorzolamide
3S76 2011-10-19 1.6 The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
3TVO 2012-08-08 1.6 Human Carbonic Anhydrase II Proton Transfer Double Mutant
2FMZ 2006-05-23 1.6 Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine, structure with D-Phenylalanine.
3DVD 2008-11-11 1.6 X-ray crystal structure of mutant N62D of human Carbonic Anhydrase II
1CIL 1994-01-31 1.6 THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS
1FR4 2001-01-17 1.6 X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
6SYB 2020-10-07 1.6 Crystal structure of carbonic anhydrase 2 with (3aR,4S,9bS)-4-(2-chloro-4-hydroxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
2QOA 2008-01-22 1.6 Crystal structure of the complex of hcaii with an indane-sulfonamide inhibitor
1G0F 2000-10-18 1.6 SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMAN CARBONIC ANHYDRASE II
4ILX 2013-02-13 1.6 Structure of human carbonic anhydrase II in complex with an adamantyl sulfonamide inhibitor
4ZX0 2015-10-28 1.6 Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor
6NJ6 2019-10-02 1.6 Thermostable variant of human carbonic anhydrase with tetrazine 2.0 at site 186 reacted with sTCO in crystallo
5E2R 2015-11-04 1.6 The crystal structure of the human carbonic anhydrase II in complex with a 1,1'-biphenyl-4-sulfonamide inhibitor
3S72 2011-10-19 1.6 The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
4IDR 2012-12-26 1.6 Human Carbonic Anhydrase II Proton Transfer Double Mutant
4LHI 2014-07-02 1.6 Crystal structure of human carbonic anhydrase isozyme II with 5-(phenylsulfonyl)thiophene-2-sulfonamide
4ZWI 2015-08-26 1.6 Surface Lysine Acetylated Human Carbonic Anhydrase II in Complex with a Sulfamate-Based Inhibitor
2POV 2007-07-24 1.6 The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-chloro-benzene-1,3-disulfonamide
3DCC 2009-03-03 1.6 Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
3RYX 2011-08-10 1.6 Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
3M40 2010-10-20 1.6 Crystal structure of human carbonic anhydrase isozyme II with 4-[N-(6-chloro-5-nitropyrimidin-4-yl)amino]benzenesulfonamide
3OY0 2011-08-10 1.6 Human Carbonic Anhydrase II complexed with 1-(4-(4-(2-(ISOPROPYLSULFONYL)PHENYLAMINO)-1H-PYRROLO[2,3-B]PYRIDIN-6-YLAMINO)-3-METHOXYPHENYL)PIPERIDIN-4-OL
3N4B 2011-03-09 1.6 Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor
5BRV 2015-06-24 1.6 Catalytic Improvement of an Artificial Metalloenzyme by Computational Design
6RMX 2020-06-03 1.6 Human Carbonic anhydrase II mutant T199V bound by 2-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-3,5,6-trifluoro-4-[(2-hydroxyethyl)thio]benzenesulfonamide
4HT0 2013-04-10 1.6 Crystal structure of human carbonic anhydrase isozyme II with the inhibitor.
3R16 2011-05-25 1.6 Human CAII bound to N-(4-sulfamoylphenyl)-2-(thiophen-2-yl) acetamide
3P3J 2011-09-21 1.6 Human carbonic anhydrase II in complex with p-(5-ruthenocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide
5JN3 2017-05-03 1.6 Carbonic Anhydrase IX-mimic IN Complex WITH U-F
4QK1 2015-03-04 1.6 Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - K170P
5TY1 2017-10-04 1.6 Identification of a New Zinc Binding Chemotype by Fragment Screening
2EU3 2006-07-11 1.6 Human Carbonic anhydrase II in complex with novel inhibitors
4IWZ 2013-12-11 1.6 structure of hCAII in complex with an acetazolamide derivative
3DC9 2009-03-03 1.6 Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
2OSM 2008-02-12 1.6 Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study
4E3D 2012-06-27 1.6 Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
3DVC 2008-11-11 1.6 X-ray crystal structure of mutant N62T of human Carbonic Anhydrase II
5SZ4 2016-12-21 1.6 Carbonic anhydrase IX-mimic in complex with 4-(phenyl)-benzenesulfonamide
3DAZ 2009-03-03 1.6 Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
2FMG 2006-05-23 1.6 Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine and crystallographic analysis of their adducts with isozyme II: sterospecific recognition within the active site of an enzyme and its consequences for the drug design, structure with L-phenylalanine
3U47 2012-10-10 1.6 Human Carbonic Anhydrase II V143L
5W8B 2018-05-30 1.6 Carbonic anhydrase II in complex with activating histamine pyridinium derivative
6E8X 2019-03-27 1.6 CA IX mimic Complexed with Steroidal Sulfamate Compound STX 140
2POU 2007-07-24 1.6 The crystal structure of the human carbonic anhydrase II in complex with 4,5-dichloro-benzene-1,3-disulfonamide
2OSF 2008-05-27 1.6 Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study
4Q7V 2015-03-11 1.6 Crystal structure of 1-hydroxy-5-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II
5BRU 2015-06-24 1.6 Catalytic Improvement of an Artificial Metalloenzyme by Computational Design
1G0E 2000-10-18 1.6 SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH 4-METHYLIMIDAZOLE
5FNI 2016-03-02 1.6 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
7JO0 2020-11-04 1.61 Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)propionamide
4ZWZ 2015-08-05 1.62 Engineered Carbonic Anhydrase IX mimic in complex with a glucosyl sulfamate inhibitor
6B5A 2018-09-05 1.62 Carbonic anhydrase IX-mimic in complex with nitrogenous base-bearing benezenesulfonamide
4CNV 2015-02-04 1.62 Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture
3V3J 2012-06-20 1.63 Kinetic and structural studies of thermostabilized mutants of HCA II.
4RFD 2015-04-15 1.63 Human carbonic anhydrase II in complex with 4-(4-sulfamoyl-phenoxy)-butylammonium
4RIV 2015-02-04 1.63 A Carbonic Anhydrase IX Mimic in Complex with Saccharin
5SZ0 2016-12-21 1.63 Carbonic anhydrase II in complex with 4-(phenyl)-benzenesulfonamide
4RUZ 2015-04-22 1.63 Crystal structure of human Carbonic Anhydrase II in complex with 4-ethoxybenzenesulfonamide
6EEA 2018-11-28 1.63 Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
5SZ2 2016-12-21 1.63 Carbonic anhydrase II in complex with 4-(3-formylphenyl)-benzenesulfonamide
4N0X 2014-01-29 1.63 Room temperature crystal structure of human carbonic anhydrase II in complex with thiophene-2-sulfonamide
6EEH 2018-11-28 1.63 Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
1TH9 2005-01-25 1.63 Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
4L5V 2014-04-30 1.63 The structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II
4R5A 2014-10-15 1.64 A Carbonic Anhydrase IX Mimic in Complex with a Carbohydrate-Based Sulfamate
6B59 2018-09-05 1.64 Carbonic anhydrase II in complex with nitrogenous base-bearing benezenesulfonamide
4RFC 2015-04-15 1.64 Human carbonic anhydrase II in complex with tert-butyl 4-(4-sulfamoylphenoxy)butylcarbamate
2X7S 2010-03-31 1.64 Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.
3KOI 2010-08-25 1.64 Crystal structure of cobalt (III) human carbonic anhydrase II at pH 6.0
2NWY 2007-04-24 1.65 Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II
3N2P 2011-03-09 1.65 Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor
4MLX 2014-07-02 1.65 Structure of a bidentate 3-hydroxy-4H-pyran-4-thione ligand bound to hCAII
3D9Z 2009-03-03 1.65 Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
3T5Z 2012-06-20 1.65 Crystal structure of the human carbonic anhydrase II in complex with N-methoxy-benzenesulfonamide
3RZ5 2011-08-10 1.65 Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
4Q7P 2015-03-11 1.65 Crystal Structure of 1-hydroxy-3-methylpyridine-2(1H)-thione bound to hCAII
3M2N 2011-02-16 1.65 Crystal structure of human carbonic anhydrase isozyme II with 4-{2-[N-(6-chloro-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide
1ZGE 2006-05-23 1.65 carbonic anhydrase II in complex with p-Sulfonamido-o,o'-dichloroaniline as sulfonamide inhibitor
4KUY 2014-06-25 1.65 Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(o-tolylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor
3MNH 2010-07-14 1.65 Human Carbonic Anhydrase II Mutant K170A
6EQU 2017-12-13 1.65 X-Ray crystal structure of the human carbonic anhydrase II adduct with a membrane-impermeant inhibitor
4R59 2014-10-15 1.65 A Carbonic Anhydrase IX Mimic in Complex with a Carbohydrate-Based Sulfamate
3IGP 2010-03-09 1.65 Structure of inhibitor binding to Carbonic Anhydrase II
4RIU 2015-02-04 1.65 A Carbonic Anhydrase IX Mimic in Complex with a Saccharin-Based Inhibitor
6YZV 2020-10-28 1.65 Closo-carborane ethyl-sulfonamide in complex with CA II
3SBH 2012-04-11 1.65 Crystal structure of human carbonic anhydrase isozyme II with 4-{[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide
4M2W 2013-11-06 1.66 Genetically engineered Carbonic Anhydrase IX in complex with Dorzolamide
1Z9Y 2006-05-23 1.66 carbonic anhydrase II in complex with furosemide as sulfonamide inhibitor
5FLO 2016-03-02 1.66 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
2VVB 2009-07-14 1.66 Human carbonic anhydrase II in complex with bicarbonate
5FNH 2016-03-02 1.66 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
6UFB 2020-08-05 1.67 Carbonic anhydrase 2 with inhibitor (2Z)-2-benzylidene-3-oxo-N-(4-sulfamoylphenyl)butanamide (11a/D1)
5FLS 2016-03-02 1.67 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
5FLT 2016-03-02 1.67 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
2CBD 1993-10-31 1.67 STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES
2CBB 1993-10-31 1.67 STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES
5FNJ 2016-03-02 1.67 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
6RM1 2020-04-15 1.68 Human Carbonic Anhydrase II in complex with fragment.
5FLR 2016-03-02 1.68 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
3M3X 2010-10-20 1.68 Crystal structure of human carbonic anhydrase isozyme II with 4-{2-[N-(6-methoxy-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide
3M1Q 2011-05-25 1.69 Carbonic Anhydrase II mutant W5C-H64C with opened disulfide bond
5SZ3 2016-12-21 1.69 Carbonic anhydrase II in complex with 4-(3-quinolinyl)-benzenesulfonamide
3HKQ 2009-10-13 1.7 Human carbonic anhydrase II in complex with 1-S-D-Galactopyranosylsulfonamide
3DVB 2008-11-11 1.7 X-ray crystal structure of mutant N62V human Carbonic Anhydrase II
3CYU 2008-05-27 1.7 Human Carbonic Anhydrase II complexed with Cryptophane biosensor and xenon
5J8Z 2016-06-29 1.7 Human carbonic anhydrase II in complex with ligand
3RZ8 2011-08-10 1.7 Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
3MHI 2010-10-20 1.7 Crystal structure of human carbonic anhydrase isozyme II with 4-{[(5-nitro-6-oxo-1,6-dihydro-4-pyrimidinyl)amino]methyl}benzenesulfonamide
4L5W 2014-04-30 1.7 Structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II
1YO1 2005-09-20 1.7 Proton Transfer from His200 in Human Carbonic Anhydrase II
5N0D 2017-05-10 1.7 Crystal structure of human carbonic anhydrase II in complex with (R)-4-(6,7-dihydroxy-1-phenyl-3,4-tetrahydroisoquinoline-1H-2-carbonyl)benzenesulfonamide.
2NXR 2007-04-24 1.7 Structural effects of hydrophobic mutations on the active site of human carbonic anhydrase II
3M5E 2010-10-20 1.7 Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-chloro-5-formyl-2-methylthiopyrimidin-4-yl)amino]methyl}benzenesulfonamide
3U45 2012-10-10 1.7 Human Carbonic Anhydrase II V143A
6YO4 2020-08-19 1.7 Para-Carborane propyl-sulfonamide in complex with CA IX mimic
3R17 2011-05-25 1.7 hCarbonic anhydrase II bound to N-(2-fluoro.4-sulfamoylphenyl)-2-(thiophen-2-yl) acetamide
3MHC 2010-07-21 1.7 Crystal structure of human cabonic anhydrase II in adduct with an adamantyl analogue of acetazolamide in a novel hydrophobic binding pocket
4HEW 2013-10-23 1.7 Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
3C7P 2009-01-13 1.7 Crystal structure of human carbonic anhydrase II in complex with STX237
1ZH9 2006-05-23 1.7 carbonic anhydrase II in complex with N-4-Methyl-1-piperazinyl-N'-(p-sulfonamide)phenylthiourea as sulfonamide inhibitor
6RW1 2019-08-28 1.7 Crystal structure of hCA II in complex with Urea, N-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-N'-(phenylmethyl)-
3D8W 2009-03-03 1.7 Use of a carbonic Anhydrase II, IX Active-site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
5L6K 2017-03-01 1.7 Crystal Structure of Human Carbonic Anhydrase II in Complex with a Quinoline Oligoamide Foldamer
3M2Z 2011-07-06 1.7 Fragment tethered to Carbonic Anhydrase II H64C mutant
1CAM 1993-10-31 1.7 STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
3DBU 2009-03-03 1.7 Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
5NEE 2017-12-06 1.7 Crystal structure of human carbonic anhydrase II in complex with the inhibitor 5-[2-(morpholine-4-carbonyl)1,3-oxazol-5-yl)]thiophene-2-sulfonammide
3DV7 2008-11-11 1.7 Role of Hydrophilic Residues in Proton Transfer During Catalysis by Human Carbonic Anhydrase II (N62A)
4ZWX 2015-10-28 1.7 Engineered Carbonic Anhydrase IX mimic in complex with glucosyl sulfamate inhibitor
4E5Q 2013-03-27 1.7 Human Carbonic Anhydrase II in complex with cyanate
3DC3 2009-03-03 1.7 Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
1MUA 1993-10-31 1.7 STRUCTURE AND ENERGETICS OF A NON-PROLINE CIS-PEPTIDYL LINKAGE IN AN ENGINEERED PROTEIN
6MBV 2019-03-13 1.7 Carbonic Anhydrase II in complex with Nicotinic Acid
5DOG 2016-09-28 1.7 Crystal structure of human carbonic anhydrase isozyme II with 2-(Benzylamino)-3,5,6-trifluoro-4-[(2-phenylethyl)thio]benzene- sulfonamide
2Q1B 2007-09-04 1.7 Carbonic Anhydrase II in Complex with Saccharin
5LMD 2016-10-19 1.7 The crystal structure of hCA II in complex with a benzoxaborole inhibitor
5FLQ 2016-03-02 1.7 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
3V2J 2012-12-26 1.7 Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II
4K1Q 2014-04-09 1.7 Structure of hCAIX mimic (hCAII with 5 mutations in active site)
4ITP 2014-01-01 1.7 Structure of human carbonic anhydrase II bound to a benzene sulfonamide
2NWO 2007-04-24 1.7 Structural and kinetic effect of hydrophobic mutations in the active site of human carbonic anhydrase II
5FLP 2016-03-02 1.71 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
2F14 2006-10-24 1.71 Tne Crystal Structure of the Human Carbonic Anhydrase II in Complex with a Fluorescent Inhibitor
6RVL 2019-08-28 1.72 Crystal structure of hCA II with Urea, N-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-?N'-phenyl-
6EEO 2018-11-28 1.72 Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
4M2V 2013-11-06 1.72 Genetically engineered Carbonic Anhydrase IX in complex with Brinzolamide
3V3I 2012-06-20 1.73 Kinetic and structural studies of thermostabilized mutants of HCA II.
4PYY 2015-01-28 1.75 Crystal structure of human carbonic anhydrase isozyme II with inhibitor
3MNJ 2010-07-14 1.75 Human Carbonic Anhydrase II Mutant K170E
1LG5 2002-07-24 1.75 Crystal Structure Analysis of the HCA II Mutant T199P in complex with beta-mercaptoethanol
3MNI 2010-07-14 1.75 Human Carbonic Anhydrase II Mutant K170D
3SAP 2012-04-11 1.75 Crystal structure of human carbonic anhydrase isozyme II with 4-{[(5-butyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide
2POW 2007-07-24 1.75 The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide
4QJM 2015-04-15 1.75 Crystal structure of human carbonic anhydrase isozyme II with inhibitor
5N0E 2017-05-10 1.75 Crystal structure of human carbonic anhydrase II in complex with (S)-4-(6,7-dihydroxy-1-phenyl-3,4-tetrahydroisoquinoline-1H-2-carbonyl)benzenesulfonamide.
3T5U 2012-06-20 1.75 Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide
3EFI 2008-09-30 1.75 Carbonic anhydrase activators: Kinetic and X-ray crystallographic study for the interaction of d- and l-tryptophan with the mammalian isoforms I-XIV
3MNK 2010-07-14 1.75 Human Carbonic Anhydrase II Mutant K170H
6T4P 2020-10-14 1.75 Human Carbonic anhydrase II bound by napthalene-1-sulfonamide
1ZGF 2006-05-23 1.75 carbonic anhydrase II in complex with trichloromethiazide as sulfonamide inhibitor
6SKV 2020-08-26 1.75 Crystal structure of bovine carbonic anhydrase II in complex with a benzenesulfonamide-based ligand (SH2)
3S73 2011-12-21 1.75 The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
6SKS 2020-08-26 1.75 Crystal structure of bovine carbonic anhydrase II in complex with a benzenesulfonamide-based ligand (SH1)
5FDC 2016-05-18 1.75 Crystal structure of Human Carbonic Anhydrase II in complex with the anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog.
1XQ0 2005-05-17 1.76 Structure of human carbonic anhydrase II with 4-[(3-bromo-4-O-sulfamoylbenzyl)(4-cyanophenyl)amino]-4H-[1,2,4]-triazole
4HBA 2013-07-31 1.76 Structural and Catalytic Characterization of a Thermal and Acid Stable Variant of Human Carbonic Anhydrase II Containing an Engineered Disulfide Bond
6E92 2019-03-27 1.77 CA IX mimic Complexed with Steroidal Sulfamate Compound STX 2845
4K0T 2014-04-09 1.78 Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with chlorzolamide
5SZ7 2016-12-21 1.78 Carbonic anhydrase IX-mimic in complex with 4-(3-quinolinyl)-benzenesulfonamide
6NLV 2020-01-15 1.79 Selective inhibition of carbonic anhydrase IX activity, using compound SLC-149, displays limited anticancer effects in breast cancer cell lines
4PYX 2015-01-28 1.8 Crystal structure of human carbonic anhydrase isozyme II with inhibitor
2FNM 2006-11-28 1.8 Activation of human carbonic anhdyrase II by exogenous proton donors
2FNN 2006-11-28 1.8 Activation of human carbonic anhydrase II by exogenous proton donors
1YO0 2005-09-20 1.8 Proton Transfer from His200 in Human Carbonic Anhydrase II
4K0S 2014-04-09 1.8 Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with acetazolamide
1THK 2005-01-25 1.8 Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
4KNI 2013-11-06 1.8 Crystal structure of human carbonic anhydrase isozyme II with 2-Chloro-4-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide
4QTL 2015-04-15 1.8 Crystal structure of human carbonic anhydrase isozyme II with inhibitor
4Q49 2015-02-25 1.8 Room temperature neutron crystal structure of apo human carbonic anhydrase at pH 7.5
1ZSC 1996-07-11 1.8 CARBONIC ANHYDRASE II MUTANT E117Q, HOLO FORM
2NXS 2007-04-24 1.8 Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II
2NWP 2007-04-24 1.8 Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II
3NB5 2011-04-20 1.8 Human carbonic anhydrase II in complex with 2-(3-chloro-4-hydroxyphenyl)-N-(4-sulfamoylphenethyl)acetamide
1G52 2000-11-08 1.8 CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL]-BENZAMIDE
3ML2 2011-04-20 1.8 Human carbonic anhydsase II in complex with an aryl sulfonamide inhibitor
5GMN 2017-05-24 1.8 Crystal structure of human carbonic anhydrase II in complex with polmacoxib
1YO2 2005-09-20 1.8 Proton Transfer from His200 in Human Carbonic Anhydrase II
3HKN 2009-10-13 1.8 Human carbonic anhydrase II in complex with (2,3,4,6-Tetra-O-acetyl-beta-D-galactopyranosyl) -(1-4)-1,2,3,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosylsulfonamide
6QFU 2019-04-17 1.8 Human carbonic anhydrase II with bound IrCp* complex (cofactor 7) to generate an artificial transfer hydrogenase (ATHase)
1CAI 1993-10-31 1.8 STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
6BCC 2018-02-28 1.8 Joint X-ray/neutron structure of human carbonic anhydrase II in complex with ethoxzolamide
3T83 2011-10-19 1.8 Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates
1RAY 1993-10-31 1.8 THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE
1TG3 2005-01-25 1.8 Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
3CAJ 2008-04-08 1.8 Crystal structure of the human carbonic anhydrase II in complex with ethoxzolamide
1CNJ 1995-07-10 1.8 X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
3PJJ 2012-01-18 1.8 Synthetic Dimer of Human Carbonic Anhydrase II
2NWZ 2007-04-24 1.8 Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II
2WD3 2010-02-23 1.8 Highly Potent First Examples of Dual Aromatase-Steroid Sulfatase Inhibitors based on a Biphenyl Template
3HKU 2009-10-13 1.8 Human carbonic anhydrase II in complex with topiramate
1I9Q 2001-03-28 1.8 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(3,4,5-TRIFLUOROPHENYL)METHYL]-BENZAMIDE
4Q7S 2015-03-11 1.8 Crystal Structure of 1-hydroxy-4-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II
5EOI 2016-11-23 1.8 Crystal structure of copper bound human Carbonic anhydrase II
3MNU 2010-06-16 1.8 Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron containing aromatic sulfamide with mammalian isoforms I-XV
2FNK 2006-11-28 1.8 Activation of Human Carbonic Anhydrase II by exogenous proton donors
4K0Z 2014-04-09 1.8 Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with methazolamide
1CNI 1995-07-10 1.8 X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
3DCS 2009-03-03 1.8 Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
3RZ0 2011-08-10 1.8 Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
2HD6 2006-10-03 1.8 Crystal structure of the human carbonic anhydrase II in complex with a hypoxia-activatable sulfonamide.
5O07 2017-08-02 1.8 The crystal structure of the human carbonic anhydrase II in complex with a nitroimidazole sulfamate inhibitor
4ZAO 2015-10-14 1.8 Genetically engineered Carbonic anhydrase IX
1RZB 1993-10-31 1.8 X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES
4XE1 2015-03-18 1.8 Human carbonic anhydrase II in complex with 6-SULFAMOYL-SACCHARIN
3RZ7 2011-08-10 1.8 Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
3M1J 2011-01-19 1.8 The crystal structure of a NAMI A-Carbonic Anhydrase II adduct discloses the mode of action of this novel anticancer metallodrug
6E91 2019-03-27 1.8 CA IX mimic Complexed with Steroidal Sulfamate Compound STX 2484
3M67 2010-11-03 1.8 Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-[(6,7-dihydro-1H-[1,4]dioxino[2,3-f]benzimidazol-2-ylsulfanyl)acetyl]benzenesulfonamide
1XEG 2005-09-27 1.81 Crystal structure of human carbonic anhydrase II complexed with an acetate ion
3FFP 2009-08-18 1.81 X ray structure of the complex between carbonic anhydrase II and LC inhibitors
4BF6 2014-01-22 1.82 Three dimensional structure of human carbonic anhydrase II in complex with 5-(1-(3-Cyanophenyl)-1H-1,2,3-triazol-4-yl)thiophene-2- sulfonamide
2CBE 1993-10-31 1.82 STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES
1G45 2000-11-08 1.83 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE
1G4J 2000-11-08 1.84 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE
1I9M 2001-03-28 1.84 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4-DIFLUOROPHENYL)METHYL]-BENZAMIDE
1G46 2000-11-08 1.84 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL]-BENZAMIDE
3BET 2008-10-07 1.85 Crystal structure of the human carbonic anhydrase II in complex with STX 641 at 1.85 angstroms resolution
1H9N 1997-09-17 1.85 H119N CARBONIC ANHYDRASE II
4FL7 2012-08-15 1.85 The crystal structure of human carbonic anhydrase II in complex with N-(Hydroxy)-benzamide
4MO8 2013-10-30 1.85 The crystal structure of the human carbonic anhydrase II in complex with N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide
5FDI 2016-05-18 1.85 Crystal structure of Human Carbonic Anhydrase II with the anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog.
1BV3 1999-09-28 1.85 HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH UREA
3EFT 2009-09-08 1.85 Crystal structure of the complex between Carbonic Anhydrase II and a spin-labeled sulfonamide incorporating TEMPO moiety
4PQ7 2014-10-08 1.85 The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide inhibitor
4PXX 2015-06-10 1.85 Crystal structure of a highly thermal stabilized variant of Human Carbonic Anhydrase II
3V3H 2012-06-20 1.85 Kinetic and structural studies of thermostabilized mutants of HCA II.
1I9O 2001-03-28 1.86 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4-TRIFLUOROPHENYL)METHYL]-BENZAMIDE
3S77 2011-10-19 1.86 The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
1G54 2000-11-08 1.86 CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE
1G3Z 2000-11-08 1.86 CARBONIC ANHYDRASE II (F131V)
1G48 2000-11-08 1.86 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE
1I9N 2001-03-28 1.86 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,5-DIFLUOROPHENYL)METHYL]-BENZAMIDE
3M2X 2011-05-25 1.87 Carbonic Anhydrase II in complex with novel sulfonamide inhibitor
2CBC 1993-10-31 1.88 STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES
6EDA 2018-11-28 1.88 Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
6EBE 2018-11-28 1.88 Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
1CAH 1993-10-31 1.88 STRUCTURE OF COBALT CARBONIC ANHYDRASE COMPLEXED WITH BICARBONATE
3B4F 2008-01-22 1.89 Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies
2X7T 2010-03-31 1.89 Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.
1RZE 1993-10-31 1.9 X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES
3RG3 2012-02-22 1.9 Crystal structure of the W5E mutant of human carbonic anhydrase II
3F4X 2009-03-17 1.9 Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules make the difference
3MHL 2010-10-20 1.9 Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-methoxy-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide
2CA2 1990-01-15 1.9 CRYSTALLOGRAPHIC STUDIES OF INHIBITOR BINDING SITES IN HUMAN CARBONIC ANHYDRASE II. A PENTACOORDINATED BINDING OF THE SCN-ION TO THE ZINC AT HIGH P*H
1BIC 1993-10-31 1.9 CRYSTALLOGRAPHIC ANALYSIS OF THR-200-> HIS HUMAN CARBONIC ANHYDRASE II AND ITS COMPLEX WITH THE SUBSTRATE, HCO3-
1CAO 1994-01-31 1.9 CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS
5LLH 2017-08-16 1.9 Crystal structure of human carbonic anhydrase isozyme II with 4-(1,3-Benzothiazol-2-ylthio)-2,3,5,6-tetrafluorobenzenesulfonamide
1RAZ 1993-10-31 1.9 THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE
3BL0 2008-01-22 1.9 Carbonic anhydrase inhibitors. Interaction of 2-N,N-Dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies
5JMZ 2017-05-03 1.9 Carbonic Anhydrase IX-mimic IN Complex WITH U-NO2
2H4N 1997-09-17 1.9 H94N CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE
1F2W 2000-06-08 1.9 THE MECHANISM OF CYANAMIDE HYDRATION CATALYZED BY CARBONIC ANHYDRASE II REVEALED BY CRYOGENIC X-RAY DIFFRACTION
1CRA 1994-01-31 1.9 THE COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND THE AROMATIC INHIBITOR 1,2,4-TRIAZOLE
3K7K 2010-01-26 1.9 Crystal structure of the complex between Carbonic Anhydrase II and anions
1LGD 2002-07-24 1.9 Crystal Structure Analysis of HCA II Mutant T199P in Complex with Bicarbonate
1YDB 1995-02-14 1.9 STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II
1CAJ 1993-10-31 1.9 STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
1TG9 2005-01-25 1.9 Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
6SKT 2020-08-26 1.9 Crystal structure of bovine carbonic anhydrase II in complex with a benzenesulfonamide-based ligand (SH0)
1UGE 1997-04-01 1.9 HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY LEU (A65L)
3DD8 2008-08-12 1.9 Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD-486019 with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies
6E8P 2019-04-03 1.9 CA IX mimic Complexed with Steroidal Sulfamate Compound STX 49
2Q1Q 2007-09-11 1.9 Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies
1RZA 1993-10-31 1.9 X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES
2HKK 2007-05-22 1.9 Carbonic anhydrase activators: Solution and X-ray crystallography for the interaction of andrenaline with various carbonic anhydrase isoforms
1BCD 1993-10-31 1.9 X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND A NEW TOPICAL INHIBITOR, TRIFLUOROMETHANE SULPHONAMIDE
1RZD 1993-10-31 1.9 X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES
1CNX 1995-11-14 1.9 SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS
1RZC 1993-10-31 1.9 X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES
5A25 2015-05-20 1.9 Rational engineering of a mesophilic carbonic anhydrase to an extreme halotolerant biocatalyst
1CAK 1993-10-31 1.9 STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
2H15 2007-03-27 1.9 Carbonic anhydrase inhibitors: Clashing with Ala65 as a means of designing isozyme-selective inhibitors that show low affinity for the ubiquitous isozyme II
4JSW 2013-06-19 1.9 Human carbonic anhydrase II H94C
4JSZ 2013-06-19 1.9 Benzenesulfonamide bound to hCAII H94C
1CNG 1995-07-10 1.9 X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
1CAN 1994-01-31 1.9 CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS
1CAZ 1993-10-31 1.9 WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE
5LLE 2017-08-16 1.9 Crystal structure of human carbonic anhydrase isozyme II with 4-(1-Adamantylamino)-2,3,5,6-tetrafluorobenzenesulfonamide
1I9P 2001-03-28 1.92 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4,6-TRIFLUOROPHENYL)METHYL]-BENZAMIDE
1IF4 2001-05-02 1.93 Carbonic Anhydrase II Complexed With 4-fluorobenzenesulfonamide
1I8Z 2001-03-28 1.93 CARBONIC ANHYDRASE II COMPLEXED WITH AL-6629 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-METHOXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE
1I9L 2001-03-28 1.93 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(4-FLUOROPHENYL)METHYL]-BENZAMIDE
3IBI 2009-09-22 1.93 The crystal structure of the human carbonic anhydrase II in complex with an aliphatic sulfamate inhibitor
6H2Z 2018-12-19 1.94 The crystal structure of human carbonic anhydrase II in complex with 4-(4-phenylpiperidine-1-carbonyl)benzenesulfonamide.
1IF8 2001-05-02 1.94 Carbonic Anhydrase II Complexed With (S)-N-(3-Indol-1-yl-2-methyl-propyl)-4-sulfamoyl-benzamide
1G53 2000-11-08 1.94 CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE
2Q38 2007-10-02 1.95 Carbonic Anhydrase II in complex with Saccharin at 1.95 Angstrom
3M5T 2011-05-25 1.95 Fragment tethered to Carbonic Anhydrase II H64C mutant
1TTM 2004-10-05 1.95 Human carbonic anhydrase II complexed with 667-coumate
4QSI 2015-01-21 1.95 Crystal structure of human carbonic anhydrase isozyme II with 5-{[(4-tert-buthyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}-2-chlorobenzenesulfonamide
1V9E 2004-02-10 1.95 Crystal Structure Analysis of Bovine Carbonic Anhydrase II
1YDC 1995-02-14 1.95 STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II
1G4O 2000-11-08 1.96 CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-PHENYLMETHYLBENZAMIDE
5L3O 2017-03-01 1.98 Crystal Structure of Human Carbonic Anhydrase II in Complex with a Quinoline Oligoamide Foldamer
3K2F 2009-11-17 1.98 Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma
3S78 2011-10-19 1.98 The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
1IF7 2001-05-02 1.98 Carbonic Anhydrase II Complexed With (R)-N-(3-Indol-1-yl-2-methyl-propyl)-4-sulfamoyl-benzamide
5EIJ 2016-11-09 1.99 Carbonic Anhydrase II in complex with Sulfonamide Inhibitor
4M2R 2013-11-06 1.99 Human Carbonic Anhydrase II in complex with Brinzolamide
1ZE8 2005-10-18 2.0 Carbonic anhydrase II in complex with a membrane-impermeant sulfonamide inhibitor
4KNJ 2013-11-06 2.0 Crystal structure of human carbonic anhydrase isozyme II with 2-Chloro-4-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide
3T84 2011-10-19 2.0 Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates
2ABE 2005-10-25 2.0 Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators
2EZ7 2006-07-18 2.0 Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII and XIV with L- and D-histidine and crystallographic analysis of their adducts with isoform II: engineering proton transfer processes within the active site of an enzyme
1UGF 1997-04-01 2.0 HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY THR (A65T)
4Y0J 2015-04-22 2.0 H/D exchanged human carbonic anhydrase II pH 6 room temperature neutron crystal structure.
3P55 2011-10-12 2.0 Human carbonic anhydrase II in complex with p-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide
1HEB 1992-10-15 2.0 STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II
1H4N 1997-09-17 2.0 H94N CARBONIC ANHYDRASE II COMPLEXED WITH TRIS
1CA2 1990-01-15 2.0 REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION
1FQL 2001-01-17 2.0 X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
4M2U 2013-11-06 2.0 Carbonic Anhydrase II in complex with Dorzolamide
6BBS 2018-02-28 2.0 Joint X-ray/neutron structure of human carbonic anhydrase II in complex with brinzolamide
1ZSB 1996-07-11 2.0 CARBONIC ANHYDRASE II MUTANT E117Q, TRANSITION STATE ANALOGUE ACETAZOLAMIDE
3P4V 2011-04-20 2.0 Human carbonic anhydrase II in complex with (+)-Xylariamide A
1IF9 2001-05-02 2.0 Carbonic Anhydrase II Complexed With N-[2-(1H-Indol-5-yl)-butyl]-4-sulfamoyl-benzamide
3KWA 2010-07-14 2.0 Polyamines inhibit carbonic anhydrases
1UGC 1997-04-01 2.0 HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY HIS (A65H)
1HEC 1992-10-15 2.0 STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II
3V3F 2012-06-20 2.0 Kinetic and structural studies of thermostabilized mutants of HCA II.
1UGD 1997-01-27 2.0 HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY SER (A65S)
4MLT 2014-07-02 2.0 Structure of a monodentate 3-hydroxy-4H-pyran-4-thione ligand bound to hCAII
4G0C 2012-09-19 2.0 Neutron structure of acetazolamide-bound human carbonic anhydrase II reveal molecular details of drug binding.
2GEH 2006-06-20 2.0 N-Hydroxyurea, a versatile zinc binding function in the design of metalloenzyme inhibitors
1T9N 2005-01-25 2.0 Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
1TBT 2005-01-25 2.0 Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
1FSR 2001-01-17 2.0 X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT
3T82 2011-10-19 2.0 Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates
1AM6 1998-06-24 2.0 CARBONIC ANHYDRASE II INHIBITOR: ACETOHYDROXAMATE
3IEO 2010-01-26 2.0 The coumarin-binding site in carbonic anhydrase: the antiepileptic lacosamide as an example
1TB0 2005-01-25 2.0 Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
1FQM 2001-01-17 2.0 X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
3CA2 1990-01-15 2.0 CRYSTALLOGRAPHIC STUDIES OF INHIBITOR BINDING SITES IN HUMAN CARBONIC ANHYDRASE II. A PENTACOORDINATED BINDING OF THE SCN-ION TO THE ZINC AT HIGH P*H
3NJ9 2011-06-22 2.0 Crystal structure of carbonic anhydrase II in complex with a Nir inhibitor
6OTI 2020-05-06 2.0 Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB9-561B
1FSQ 2001-01-17 2.0 X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT
1IF5 2001-05-02 2.0 Carbonic Anhydrase II Complexed With 2,6-difluorobenzenesulfonamide
1TEQ 2005-01-25 2.0 Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
5BNL 2015-07-15 2.0 Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins
1FQN 2001-01-17 2.0 X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
1FSN 2001-01-17 2.0 X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT
1HED 1992-10-15 2.0 STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II
1I91 2001-03-28 2.0 CARBONIC ANHYDRASE II COMPLEXED WITH AL-6619 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-HYDROXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE
1HEA 1992-10-15 2.0 CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) (HCA II) (E.C.4.2.1.1) MUTANT WITH LEU 198 REPLACED BY ARG (L198R)
1AVN 1997-12-24 2.0 HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH THE HISTAMINE ACTIVATOR
3F8E 2009-10-06 2.0 Coumarins are a novel class of suicide carbonic anhydrase inhibitors
1TEU 2005-01-25 2.0 Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
1CNW 1995-11-14 2.0 SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS
3KKX 2010-01-12 2.0 Neutron structure of human carbonic anhydrase II
1UGB 1997-01-27 2.0 HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY GLY (A65G)
1TE3 2005-01-25 2.0 Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
1UGA 1997-01-27 2.0 HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY PHE (A65F)
1I90 2001-03-28 2.0 CARBONIC ANHYDRASE II COMPLEXED WITH AL-8520 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 4-AMINO-3,4-DIHYDRO-2-(3-METHOXYPROPYL)-, 1,1-DIOXIDE, (R)
1FQR 2001-01-17 2.0 X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
3TMJ 2011-11-09 2.0 Joint X-ray/neutron structure of human carbonic anhydrase II at pH 7.8
4Z1E 2015-08-26 2.01 Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)
1XPZ 2005-05-17 2.02 Structure of human carbonic anhydrase II with 4-[4-O-sulfamoylbenzyl)(4-cyanophenyl)amino]-4H-[1,2,4]-triazole
4CNW 2015-02-04 2.03 Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture
1G1D 2000-11-08 2.04 CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE
1CNH 1995-07-10 2.05 X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
4L5U 2014-04-30 2.05 The structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II
5FNG 2016-03-02 2.05 Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
6RVF 2019-08-28 2.07 Crystal structure of hCA II in complex with Urea, N-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-N'-phenyl
1IF6 2001-05-02 2.09 Carbonic Anhydrase II Complexed With 3,5-difluorobenzenesulfonamide
2WEH 2009-11-10 2.09 Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors
2HOC 2006-10-10 2.1 Crystal structure of the human carbonic anhydrase II in complex with the 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide inhibitor
1YDA 1995-02-14 2.1 STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II
1OKL 1997-01-11 2.1 CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKL INHIBITOR 5-DIMETHYLAMINO-NAPHTHALENE-1-SULFONAMIDE
5CA2 1992-10-31 2.1 CONFORMATIONAL MOBILITY OF HIS-64 IN THE THR-200 (RIGHT ARROW) SER MUTANT OF HUMAN CARBONIC ANHYDRASE II
2O4Z 2007-05-15 2.1 Crystal structure of the Carbonic Anhydrase II complexed with hydroxysulfamide inhibitor
1BN4 1999-05-18 2.1 CARBONIC ANHYDRASE II INHIBITOR
3HFP 2010-05-19 2.1 Crystal structure of teh complex between CA II and the activator MAI
1BN1 1999-05-18 2.1 CARBONIC ANHYDRASE II INHIBITOR
1YDD 1995-02-14 2.1 STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II
1CIN 1994-01-31 2.1 THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS
3BL1 2008-07-01 2.1 Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited old leads for new applications
3NI5 2011-06-22 2.1 Carbonic anhydrase inhibitor: C1 family
1CAY 1993-10-31 2.1 WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE
1DCB 1993-07-15 2.1 STRUCTURE OF AN ENGINEERED METAL BINDING SITE IN HUMAN CARBONIC ANHYDRASE II REVEALS THE ARCHITECTURE OF A REGULATORY CYSTEINE SWITCH
3RGE 2012-02-22 2.1 Crystal structure of the W5H mutant of human carbonic anhydrase II
1CIM 1994-01-31 2.1 THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS
1EOU 2002-02-13 2.1 CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH AN ANTICONVULSANT SUGAR SULFAMATE
4CA2 1992-10-31 2.1 ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II
2X7U 2010-03-31 2.12 Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.
5UMC 2017-12-06 2.15 Synthesis of novel seleno ureido containing compounds as SLC-0111 analogs. Investigations on carbonic anhydrases activity, glutathione peroxidase and X-ray crystallography
4LP6 2013-10-23 2.15 Crystal Structure of Human Carbonic Anhydrase II in complex with a quinoline oligoamide foldamer
1BNT 1999-06-15 2.15 CARBONIC ANHYDRASE II INHIBITOR
1BNU 1999-06-15 2.15 CARBONIC ANHYDRASE II INHIBITOR
1CNK 1995-07-10 2.15 X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
1CAL 1993-10-31 2.2 STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
3P44 2011-10-12 2.2 Human carbonic anhydrase II in complex with p-(4-ruthenocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide
1CVD 1994-12-20 2.2 STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE
1UGG 1997-01-27 2.2 HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY SER (A65S)-ORTHORHOMBIC FORM
1CNC 1994-10-15 2.2 COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES
1H9Q 1997-09-17 2.2 H119Q CARBONIC ANHYDRASE II
1BN3 1999-05-18 2.2 CARBONIC ANHYDRASE II INHIBITOR
1OKM 1997-01-11 2.2 CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKM INHIBITOR 4-SULFONAMIDE-[1-(4-AMINOBUTANE)]BENZAMIDE
3IBN 2009-09-22 2.2 The crystal structure of the human carbonic anhydrase II in complex with an aliphatic bis-sulfamate inhibitor
1CCT 1995-02-07 2.2 STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY
5CAC 1994-01-31 2.2 REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION
4CAC 1994-01-31 2.2 REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION
5L70 2017-06-21 2.2 CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER
1LG6 2002-07-24 2.2 Crystal Structure Analysis of HCA II Mutant T199P in Complex with Thiocyanate
1XEV 2005-09-20 2.2 Crystal structure of human carbonic anhydrase II in a new crystal form
1DCA 1993-07-15 2.2 STRUCTURE OF AN ENGINEERED METAL BINDING SITE IN HUMAN CARBONIC ANHYDRASE II REVEALS THE ARCHITECTURE OF A REGULATORY CYSTEINE SWITCH
6ECZ 2018-11-28 2.21 Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
6Q3O 2019-12-25 2.23 PROTEIN-AROMATIC FOLDAMER COMPLEX CRYSTAL STRUCTURE
1CCU 1995-02-07 2.25 STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY
1A42 1999-03-23 2.25 HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH BRINZOLAMIDE
1CVF 1994-11-30 2.25 STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE
1CVA 1993-10-31 2.25 STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II
1CVE 1994-11-30 2.25 STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE
1KWR 2003-01-07 2.25 HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH INHIBITOR 0134-36
1BNW 1999-06-15 2.25 CARBONIC ANHYDRASE II INHIBITOR
4CNR 2015-02-04 2.29 Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture
1HVA 1993-10-31 2.3 ENGINEERING THE ZINC BINDING SITE OF HUMAN CARBONIC ANHYDRASE II: STRUCTURE OF THE HIS-94-> CYS APOENZYME IN A NEW CRYSTALLINE FORM
1CNY 1995-11-14 2.3 SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS
1LZV 2002-10-23 2.3 Site-Specific Mutant (Tyr7 replaced with His) of Human Carbonic Anhydrase II
1CA3 1992-10-15 2.3 UNEXPECTED PH-DEPENDENT CONFORMATION OF HIS-64, THE PROTON SHUTTLE OF CARBONIC ANHYDRASE II.
1CVC 1994-01-31 2.3 REDESIGNING THE ZINC BINDING SITE OF HUMAN CARBONIC ANHYDRASE II: STRUCTURE OF A HIS2ASP-ZN2+ METAL COORDINATION POLYHEDRON
1CVH 1995-02-07 2.3 STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE
1BNN 1999-05-18 2.3 CARBONIC ANHYDRASE II INHIBITOR
1HCA 1992-10-15 2.3 UNEXPECTED PH-DEPENDENT CONFORMATION OF HIS-64, THE PROTON SHUTTLE OF CARBONIC ANHYDRASE II.
1CCS 1995-02-07 2.35 STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY
1CNB 1994-10-15 2.35 COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES
3HKT 2009-10-13 2.36 Human carbonic anhydrase II in complex with alpha-D-Glucopyranosyl-(1->4)-1-thio-beta-D-glucopyranosylsulfonamide
1BNQ 1999-06-15 2.4 CARBONIC ANHYDRASE II INHIBITOR
7CA2 1992-07-15 2.4 ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II
1BNV 1999-02-16 2.4 CARBONIC ANHYDRASE II INHIBITOR
1OKN 1997-01-11 2.4 CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKN INHIBITOR 4-SULFONAMIDE-[1-(4-N-(5-FLUORESCEIN THIOUREA)BUTANE)]
12CA 1992-10-15 2.4 ALTERING THE MOUTH OF A HYDROPHOBIC POCKET. STRUCTURE AND KINETICS OF HUMAN CARBONIC ANHYDRASE II MUTANTS AT RESIDUE VAL-121
1CVB 1993-10-31 2.4 STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II
3T85 2011-10-19 2.4 Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates
8CA2 1992-07-15 2.4 ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II
6YMB 2020-08-12 2.5 MicroED structure of human carbonic anhydrase II
1ZSA 1996-07-11 2.5 CARBONIC ANHYDRASE II MUTANT E117Q, APO FORM
6YMA 2020-08-12 2.5 MicroED structure of acetazolamide-bound human carbonic anhydrase II
6CA2 1992-07-15 2.5 ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II
1KWQ 2003-01-07 2.6 HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH INHIBITOR 2000-07
1BNM 1999-05-18 2.6 CARBONIC ANHYDRASE II INHIBITOR
5L6T 2017-06-21 2.65 CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER
6Q9T 2019-09-18 2.68 Protein-aromatic foldamer complex crystal structure
9CA2 1992-07-15 2.8 ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II
5L9E 2017-06-21 2.9 CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER
6HZX 2019-09-18 2.91 Protein-aromatic foldamer complex crystal structure
1V9I 2004-02-10 2.95 Crystal Structure Analysis of the site specific mutant (Q253C) of bovine carbonic anhydrase II
1G6V 2000-11-22 3.5 Complex of the camelid heavy-chain antibody fragment CAB-CA05 with bovine carbonic anhydrase

Relevant UniProtKB Entries

Percent Identity Matching Chains Protein Accession Entry Name
100.0 Carbonic anhydrase 2 P86277 BIOR_THESB
92.3 Carbonic anhydrase 2 P00922 CAH2_SHEEP
100.0 Carbonic anhydrase 2 P00921 CAH2_BOVIN
100.0 A Carbonic anhydrase 2 P00918 CAH2_HUMAN