The folding landscape of Streptomyces griseus protease B reveals the energetic costs and benefits associated with evolving kinetic stability.


Abstract

Like most extracellular bacterial proteases, Streptomyces griseus protease B (SGPB) and alpha-lytic protease (alphaLP) are synthesized with covalently attached pro regions necessary for their folding. In this article, we characterize the folding free energy landscape of SGPB and compare it to the folding landscapes of alphaLP and trypsin, a mammalian homolog that folds independently of its zymogen peptide. In contrast to the thermodynamically stable native state of trypsin, SGPB and alphaLP fold to native states that are thermodynamically marginally stable or unstable, respectively. Instead, their apparent stability arises kinetically, from unfolding free energy barriers that are both large and highly cooperative. The unique unfolding transitions of SGPB and alphaLP extend their functional lifetimes under highly degradatory conditions beyond that seen for trypsin; however, the penalty for evolving kinetic stability is remarkably large in that each factor of 2.4-8 in protease resistance is accompanied by a cost of ~10(5) in the spontaneous folding rate and ~5-9 kcal/mole in thermodynamic stability. These penalties have been overcome by the coevolution of increasingly effective pro regions to facilitate folding. Despite these costs, kinetic stability appears to be a potent mechanism for developing native-state properties that maximize protease longevity. Study holds ProTherm entries: 16833, 16834, 16835 Extra Details: Streptomyces griseus protease B; protein folding; pro region; kinetic stability; protein evolution

Submission Details

ID: 2gpAU9C6

Submitter: Connie Wang

Submission Date: April 24, 2018, 8:48 p.m.

Version: 1

Publication Details
Truhlar SM;Cunningham EL;Agard DA,Protein Sci. (2004) The folding landscape of Streptomyces griseus protease B reveals the energetic costs and benefits associated with evolving kinetic stability. PMID:14718653
Additional Information

Study Summary

Number of data points 3
Proteins Anionic trypsin ; Alpha-lytic protease ; Cationic trypsin ; Streptogrisin-B ; Streptogrisin-B ; Alpha-lytic protease
Unique complexes 3
Assays/Quantities/Protocols Experimental Assay: dG_H2O prot_conc:1.75 microM, ionic:: ; Experimental Assay: dG_H2O prot_conc:2 microM, ionic:calcium chloride: 10 mM
Libraries Mutations for sequence IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN ; Mutations for sequence E:ISGGDAIYSSTGRCSLGFNVRSGSTYYFLTAGHCTDGATTWWANSARTTVLGTTSGSSFPNNDYGIVRYTNTTIPKDGTVGGQDITSAANATVGMAVTRRGSTTGTHSGSVTALNATVNYGGGDVVYGMIRTNVCAEPGDSGGPLYSGTRAIGLTSGGSGNCSSGGTTFFQPVTEALVAYGVSVY/I:PICTNCCAGYKGCNYYSANGAFICEGQSDPKKPKACPLNCDPHIAYSKCPR ; Mutations for sequence A:ANIVGGIEYSINNASLCSVGFSVTRGATKGFVTAGHCGTVNATARIGGAVVGTFAARVFPGNDRAWVSLTSAQTLLPRVANGSSFVTVRGSTEAAVGAAVCRSGRTTGYQCGTITAKNVTANYAEGAVRGLTQGNACMGRGDSGGSWITSAGQAQGVASGGNVQSNGNNCGIPASQRSSLFERLQPILSQYGLSLVTG/B:ANIVGGIEYSINNASLCSVGFSVTRGATKGFVTAGHCGTVNATARIGGAVVGTFAARVFPGNDRAWVSLTSAQTLLPRVANGSSFVTVRGSTEAAVGAAVCRSGRTTGYQCGTITAKNVTANYAEGAVRGLTQGNACMGRGDSGGSWITSAGQAQGVASGGNVQSNGNNCGIPASQRSSLFERLQPILSQYGLSLVTG/C:ADQVDPQLKFAMQRDLGIFPTQLPQYLQTEKLARTQAAAIEREFGAQFAGSWIERNEDGSFKLVAATSGARKSSTLGGVEVRNVRYSLKQLQSAMEQLDAGANARVKGVSKPLDGVQSWYVDPRSNAVVVKVDDGATDAGVDFVALSGADSAQVRIESSPGKLQTT/D:ADQVDPQLKFAMQRDLGIFPTQLPQYLQTEKLARTQAAAIEREFGAQFAGSWIERNEDGSFKLVAATSGARKSSTLGGVEVRNVRYSLKQLQSAMEQLDAGANARVKGVSKPLDGVQSWYVDPRSNAVVVKVDDGATDAGVDFVALSGADSAQVRIESSPGKLQTT

Structure view and single mutant data analysis

Study data

No weblogo for data of varying length.
Colors: D E R H K S T N Q A V I L M F Y W C G P
 

Data Distribution

Studies with similar sequences (approximate matches)

Correlation with other assays (exact sequence matches)


Relevant PDB Entries

Structure ID Release Date Resolution Structure Title
5MOR 2018-02-28 Joint X-ray/neutron structure of cationic trypsin in complex with benzylamine
5MON 2017-05-24 Joint X-ray/neutron structure of cationic trypsin in complex with 2-aminopyridine
5MOS 2018-02-28 Joint X-ray/neutron structure of cationic trypsin in complex with N-amidinopiperidine
5WOT 2018-02-07 NMR solution structure of a-lytic protease using two 4D-spectra
5MOP 2018-01-17 Joint X-ray/neutron structure of cationic trypsin in its apo form
5MOO 2017-05-24 Joint X-ray/neutron structure of cationic trypsin in complex with aniline
3OTJ 2011-01-26 A Crystal Structure of Trypsin Complexed with BPTI (Bovine Pancreatic Trypsin Inhibitor) by X-ray/Neutron Joint Refinement
5MOQ 2018-02-28 Joint X-ray/neutron structure of cationic trypsin in complex with benzamidine
4I8H 2012-12-19 0.75 Bovine trypsin at 0.75 resolution
5MN1 2017-05-24 0.79 Cationic trypsin in complex with 2-aminopyridine (deuterated sample at 100 K)
3MI4 2010-04-28 0.8 Bovine trypsin at 0.8 A resolution, non-restrained refinement
5MNK 2018-01-17 0.8 Cationic trypsin in complex with benzylamine (deuterated sample at 100 K)
3MFJ 2010-04-21 0.8 Bovine trypsin at 0.8 A resolution, restrained refinement
4I8G 2012-12-19 0.8 Bovine trypsin at 0.8 resolution
2H5C 2006-09-26 0.82 0.82A resolution crystal structure of alpha-lytic protease at pH 5
1SSX 2004-05-04 0.83 0.83A resolution crystal structure of alpha-lytic protease at pH 8
4I8K 2012-12-19 0.85 Bovine trypsin at 0.85 resolution
5MNG 2018-01-17 0.86 Cationic trypsin in complex with benzamidine (deuterated sample at 100 K)
5MNN 2018-01-17 0.86 Cationic trypsin in complex with N-amidinopiperidine (deuterated sample at 100 K)
4I8L 2012-12-19 0.87 Bovine trypsin at 0.87 resolution
4I8J 2012-12-19 0.87 Bovine trypsin at 0.87 A resolution
2H5D 2006-09-26 0.9 0.9A resolution crystal structure of alpha-lytic protease complexed with a transition state analogue, MeOSuc-Ala-Ala-Pro-Val boronic acid
4XOJ 2015-08-12 0.91 Structure of bovine trypsin in complex with analogues of sunflower inhibitor 1 (SFTI-1)
5MNC 2017-05-24 0.92 Cationic trypsin in complex with aniline (deuterated sample at 100 K)
5MNH 2018-01-17 0.93 Cationic trypsin in complex with benzamidine (deuterated sample at 295 K)
2XTT 2010-11-10 0.93 Bovine trypsin in complex with evolutionary enhanced Schistocerca gregaria protease inhibitor 1 (SGPI-1-P02)
5MNB 2017-05-24 0.94 Cationic trypsin in complex with 2-aminopyridine (deuterated sample at 295 K)
1HJ9 2002-01-04 0.95 Atomic resolution structures of trypsin provide insight into structural radiation damage
6SY3 2020-05-13 0.95 Cationic Trypsin in Complex with a D-DiPhe-Pro-pyridine derivative
5MNO 2018-01-17 0.96 Cationic trypsin in complex with N-amidinopiperidine (deuterated sample at 295 K)
2AYW 2006-01-17 0.97 Crystal Structure of the complex formed between trypsin and a designed synthetic highly potent inhibitor in the presence of benzamidine at 0.97 A resolution
5MNM 2018-01-17 0.98 Cationic trypsin in complex with benzylamine (at 295 K)
5MNF 2018-01-17 0.99 Cationic trypsin in its apo form (deuterated sample at 295 K)
4U2W 2015-01-14 1.0 Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin
4NIV 2014-02-19 1.0 Crystal structure of trypsiligase (K60E/N143H/Y151H/D189K trypsin) trigonal form
5MNE 2018-01-17 1.01 Cationic trypsin in its apo form (deuterated sample at 100 K)
5MNP 2018-01-17 1.01 Cationic trypsin in complex with N-amidinopiperidine (at 295 K)
1S0R 2005-01-18 1.02 Bovine Pancreatic Trypsin inhibited with Benzamidine at Atomic resolution
1S0Q 2005-01-18 1.02 Native Bovine Pancreatic Trypsin
5MNL 2018-01-17 1.04 Cationic trypsin in complex with benzylamine (deuterated sample at 295 K)
7BS6 2020-08-26 1.04 Bovine Pancreatic Trypsin with 2-Methyltryptamine (Cryo)
7BS4 2020-08-26 1.04 Bovine Pancreatic Trypsin with 5-Methoxytryptamine (Cryo)
7BS7 2020-08-26 1.04 Bovine Pancreatic Trypsin with aniline (Cryo)
7BS9 2020-08-26 1.05 Bovine Pancreatic Trypsin with serotonin (Cryo)
3M7U 2011-02-09 1.05 Crystal Structure of Alpha-Lytic Protease SB1+2 R64A/E182Q Mutant
6T9U 2020-11-18 1.07 Bovine Trypsine in complex with the synthetic inhibitor (S)-3'-(N-(1-(4-(3-(tert-butyl)ureido)piperidin-1-yl)-3-(3-carbamimidoylphenyl)-1-oxopropan-2-yl)sulfamoyl)-[1,1'-biphenyl]-3-carboximidamide (MI-490)
3URD 2012-05-23 1.08 T181A mutant of alpha-Lytic Protease
3URC 2012-05-23 1.1 T181G mutant of alpha-Lytic Protease
5F6M 2016-01-06 1.1 Isotropic Trypsin Model for Comparison of Diffuse Scattering
3NKK 2010-11-10 1.12 Trypsin in complex with fluorine containing fragment
5LGO 2016-08-10 1.12 Trypsin inhibitors for the treatment of pancreatitis - cpd 15
2AH4 2006-05-16 1.13 guanidinobenzoyl-trypsin acyl-enzyme at 1.13 A resolution
6T5W 2020-05-13 1.13 Cationic Trypsin in Complex with a D-Phe-Pro-p-aminopyridine Derivative (cocrystallizaton at 291 K)
6T9V 2020-11-18 1.13 Bovine Trypsin in complex with the synthetic inhibitor (S)-3-(3-(4-(3-(tert-butyl)ureido)piperidin-1-yl)-2-((3'-fluoro-4'-(hydroxymethyl)-[1,1'-biphenyl])-3-sulfonamido)-3-oxopropyl)benzimidamide (MI-1904)
2AGI 2006-05-16 1.14 The leupeptin-trypsin covalent complex at 1.14 A resolution
6SVV 2020-01-22 1.15 Reference structure of bovine trypsin (odd frames of crystal x30)
6SVZ 2020-01-22 1.15 Reference structure of bovine trypsin (even frames of crystal x34)
6SVB 2020-01-22 1.15 Terahertz irradiated structure of bovine trypsin (odd frames of crystal x40)
1UTO 2004-01-15 1.15 Trypsin specificity as elucidated by LIE calculations, X-ray structures and association constant measurements
6SW0 2020-01-22 1.15 Reference structure of bovine trypsin (odd frames of crystal x34)
6EAT 2019-03-13 1.15 Crystallographic structure of the cyclic nonapeptide derived from the BTCI inhibitor bound to beta-trypsin in space group P 21 21 21.
6SVD 2020-01-22 1.15 Non-terahertz irradiated structure of bovine trypsin (even frames of crystal x41)
1UTN 2004-01-09 1.15 Trypsin specificity as elucidated by LIE calculations, X-ray structures and association constant measurements
2AGE 2006-05-16 1.15 Succinyl-AAPR-trypsin acyl-enzyme at 1.15 A resolution
6SV6 2020-01-22 1.15 Non-terahertz irradiated structure of bovine trypsin (even frames of crystal x38)
2UUY 2007-04-10 1.15 Structure of a tick tryptase inhibitor in complex with bovine trypsin
6SV9 2020-01-22 1.15 Non-terahertz irradiated structure of bovine trypsin (even frames of crystal x40)
1UTQ 2004-01-15 1.15 Trypsin specificity as elucidated by LIE calculations, X-ray structures and association constant measurements
6SV8 2020-01-22 1.15 Terahertz irradiated structure of bovine trypsin (odd frames of crystal x38)
3NK8 2010-11-10 1.15 Trypsin in complex with fluorine-containing fragment
6SVU 2020-01-22 1.15 Reference structure of bovine trypsin (even frames of crystal x30)
6SVG 2020-01-22 1.16 Terahertz irradiated structure of bovine trypsin (odd frames of crystal x41)
6SVW 2020-01-22 1.16 Reference structure of bovine trypsin (even frames of crystal x33)
6SVN 2020-01-22 1.16 Reference structure of bovine trypsin (even frames of crystal x28)
6SVR 2020-01-22 1.16 Reference structure of bovine trypsin (odd frames of crystal x28)
6SUX 2020-01-22 1.16 Terahertz irradiated structure of bovine trypsin (even frames of crystal x37)
6SVJ 2020-01-22 1.16 Terahertz irradiated structure of bovine trypsin (odd frames of crystal x42)
6SV0 2020-01-22 1.16 Non-terahertz irradiated structure of bovine trypsin (odd frames of crystal x37)
6SVX 2020-01-22 1.16 Reference structure of bovine trypsin (odd frames of crystal x33)
6SVI 2020-01-22 1.16 Non-terahertz irradiated structure of bovine trypsin (even frames of crystal x42)
7BS5 2020-08-26 1.17 Bovine Pancreatic Trypsin with 6-Methoxytryptamine (Cryo)
6EAU 2019-08-07 1.18 Crystallographic structure of the octapeptide derived from the BTCI inhibitor bound to beta-trypsin in space group P 21 21 21.
2QA9 2007-12-11 1.18 Crystal structure of the second tetrahedral intermediates of SGPB at pH 4.2
3PLB 2011-12-07 1.18 Bovine trypsin variant X(tripleIle227) in complex with small molecule inhibitor
6EAX 2019-08-07 1.19 Crystallographic structure of the cyclic hexapeptide derived from the BTCI inhibitor bound to beta-trypsin in space group P 21 21 21
6T0P 2020-05-13 1.19 Cationic Trypsin in Complex with a D-Phe-Pro-2-aminopyridine derivative
2BLW 2005-09-07 1.2 Trypsin after a high dose X-ray 'Burn'
1QQ4 1999-06-15 1.2 CRYSTAL STRUCTURE OF AN ALPHA-LYTIC PROTEASE MUTANT WITH ACCELERATED FOLDING KINETICS, R102H/G134S
1Y59 2005-12-13 1.2 Dianhydrosugar-based benzamidine, factor Xa specific inhibitor in complex with bovine trypsin mutant
3UNR 2012-06-27 1.2 Bond length analysis of asp, glu and his residues in trypsin at 1.2A resolution
2BLV 2005-09-07 1.2 Trypsin before a high dose x-ray 'burn'
4YTA 2015-05-27 1.2 BOND LENGTH ANALYSIS OF ASP, GLU AND HIS RESIDUES IN TRYPSIN AT 1.2A RESOLUTION
4AB9 2012-02-08 1.2 Fragments bound to bovine trypsin for the SAMPL challenge
1QRW 1999-06-18 1.2 CRYSTAL STRUCTURE OF AN ALPHA-LYTIC PROTEASE MUTANT WITH ACCELERATED FOLDING KINETICS, R102H/G134S, PH 8
1J8A 2001-09-12 1.21 CRYSTAL STRUCTURE OF BENZAMIDINE INHIBITED BOVINE PANCREATIC TRYPSIN AT 105K TO 1.21A RESOLUTION FROM LABORATORY SOURCE WITH HIGH NUMBER OF WATERS MODELLED
4MTB 2014-12-24 1.22 Bovine trypsin in complex with small molecule inhibitor
7BSA 2020-08-26 1.22 Bovine Pancreatic Trypsin with 5-Chlorotryptamine (Cryo)
2QAA 2007-12-11 1.23 Crystal structure of the second tetrahedral intermediates of SGPB at pH 7.3
4ABD 2012-02-08 1.25 Fragments bound to bovine trypsin for the SAMPL challenge
4ABH 2012-02-08 1.25 Fragments bound to bovine trypsin for the SAMPL challenge
4Y0Y 2015-06-24 1.25 Trypsin in complex with with BPTI
4ABB 2012-02-08 1.25 Fragments bound to bovine trypsin for the SAMPL challenge
4ABA 2012-02-08 1.25 Fragments bound to bovine trypsin for the SAMPL challenge
2AGG 2006-05-16 1.28 succinyl-AAPK-trypsin acyl-enzyme at 1.28 A resolution
7BS3 2020-08-26 1.28 Bovine Pancreatic Trypsin with 4-Bromo-benzamidine (Cryo)
6MRQ 2020-07-01 1.29 Structure of ToPI1 inhibitor from Tityus obscurus scorpion venom in complex with trypsin
6EAW 2019-08-07 1.29 Crystallographic structure of the cyclic heptapeptide derived from the BTCI inhibitor bound to beta-trypsin in space group P 21 21 21
6BFP 2018-10-31 1.29 Bovine trypsin bound to potent inhibitor
4HGC 2013-10-09 1.29 Crystal structure of bovine trypsin complexed with sfti-1 analog containing a peptoid residue at position p1
2BY6 2006-02-06 1.3 Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection
2BY7 2006-02-06 1.3 Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection
1UTP 2004-01-15 1.3 Trypsin specificity as elucidated by LIE calculations, X-ray structures and association constant measurements
4ABF 2012-02-08 1.3 Fragments bound to bovine trypsin for the SAMPL challenge
4Y11 2015-06-24 1.3 Trypsin in complex with with BPTI mutant (2S)-2-amino-4,4,4-trifluorobutanoic acid
3QGJ 2012-02-01 1.3 1.3A Structure of alpha-Lytic Protease Bound to Ac-AlaAlaPro-Alanal
2BYA 2006-02-06 1.3 Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection
2BY5 2006-02-06 1.3 Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection
4NIX 2014-02-19 1.3 Crystal structure of trypsiligase (K60E/N143H/Y151H/D189K trypsin) orthorhombic form, zinc-bound
2BY9 2006-02-06 1.3 Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection
4ABE 2012-02-08 1.3 Fragments bound to bovine trypsin for the SAMPL challenge
2BY8 2006-02-06 1.3 Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection
7BRZ 2020-08-26 1.3 Bovine Pancreatic Trypsin with 2-Methyltryptamine (Room Temperature)
4TPY 2014-10-22 1.3 High throughput screening using acoustic droplet ejection to combine protein crystals and chemical libraries on crystallization plates at high density
4KTS 2014-04-02 1.3 Bovine trypsin in complex with microviridin J at pH 8.5
4NIW 2014-02-19 1.31 Crystal structure of trypsiligase (K60E/N143H/Y151H/D189K trypsin) orthorhombic form
2OXS 2007-03-13 1.32 Crystal Structure of the trypsin complex with benzamidine at high temperature (35 C)
6DWR 2019-07-03 1.32 Trypsin serine protease modified with the protease inhibitor cyanobenzylsulfonylfluoride
5EG4 2016-07-13 1.32 BOVINE TRYPSIN IN COMPLEX WITH CYCLIC INHIBITOR
1O3D 2003-09-02 1.33 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
5MNQ 2018-01-17 1.34 Cationic trypsin in complex with a derivative of N-amidinopiperidine
5PTP 1997-07-07 1.34 STRUCTURE OF HYDROLASE (SERINE PROTEINASE)
7BRX 2020-08-26 1.35 Bovine Pancreatic Trypsin with 5-Methoxytryptamine (Room Temperature)
4KTU 2014-04-02 1.35 Bovine trypsin in complex with microviridin J at pH 6.5
1P2J 2004-04-20 1.35 Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin
4B2B 2012-08-01 1.36 Structure of the factor Xa-like trypsin variant triple-Ala (TGPA) in complex with eglin C
1C5S 2000-12-22 1.36 STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
4Y0Z 2015-06-24 1.37 Trypsin in complex with with BPTI mutant AMINOBUTYRIC ACID
1C5T 2000-12-22 1.37 STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
4Y10 2015-06-24 1.37 Trypsin in complex with with BPTI mutant (2S)-2-amino-4,4-difluorobutanoic acid
5LH4 2018-01-17 1.37 Trypsin inhibitors for the treatment of pancreatitis - cpd 1
1C1T 2000-07-26 1.37 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1C5U 2000-12-22 1.37 STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
1GI4 2002-01-22 1.37 A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
1C1Q 2000-07-26 1.37 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1C1P 2000-07-26 1.37 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
7BS8 2020-08-26 1.37 Bovine Pancreatic Trypsin with Benzamidine (Cryo)
1C1R 2000-07-26 1.37 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1O38 2003-09-02 1.38 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1O2W 2003-09-02 1.38 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1GI2 2002-01-22 1.38 A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
1GHZ 2002-01-22 1.39 A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
6EAV 2019-08-07 1.39 Crystallographic structure of the cyclic heptapeptide derived from the BTCI inhibitor bound to beta-trypsin in space group P 4(1) 2(1) 2
1O3L 2003-09-02 1.4 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1Y5A 2005-12-13 1.4 Dianhydrosugar-based benzamidine, factor Xa specific inhibitor in complex with bovine trypsin mutant
1TPP 1983-01-18 1.4 THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS
6VXY 2020-07-01 1.4 Triazole bridged SFTI1 inhibitor in complex with beta-trypsin
1C2J 2000-07-26 1.4 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1C2H 2000-07-26 1.4 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
2ZQ2 2009-08-04 1.4 Exploring trypsin S3 pocket
1C1N 2000-07-26 1.4 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1C1O 2000-07-26 1.4 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
3A8A 2010-09-29 1.4 Crystal Structure of Trypsin complexed with 4-formylbenzimidamide and aniline
1C2M 2000-07-26 1.4 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1N6X 2003-03-04 1.4 RIP-phasing on Bovine Trypsin
1SGP 1995-10-15 1.4 ALA 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B
1O3J 2003-09-02 1.4 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1N6Y 2003-03-04 1.4 RIP-phasing on Bovine Trypsin
1O2U 2003-09-02 1.41 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1O35 2003-09-02 1.41 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
2G8T 2006-09-05 1.41 Indole-amidine Complexes with Bovine Trypsin
4NCY 2014-04-09 1.42 In situ trypsin crystallized on a MiTeGen micromesh with imidazole ligand
6QIH 2020-02-05 1.42 Pancreatic Bovine Trypsin with a boronic acid inhibitor
1GI0 2002-01-22 1.42 A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
1GI1 2002-01-22 1.42 A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
6U22 2020-07-01 1.42 Crystal structure of SFTI-triazole inhibitor in complex with beta-trypsin
5MNX 2017-05-24 1.42 Neutron structure of cationic trypsin in complex with 2-aminopyridine
5MNY 2017-05-24 1.43 Neutron structure of cationic trypsin in complex with aniline
4B2C 2012-08-01 1.43 Structure of the factor Xa-like trypsin variant triple-Ala (TPA) in complex with eglin C
6SWV 2020-05-20 1.43 Trypsin fast data collection
1O3K 2003-09-02 1.43 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1C5P 2000-12-22 1.43 STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
3UWI 2012-12-05 1.43 Bovine trypsin variant X(tripleGlu217Phe227) in complex with small molecule inhibitor
1C5Q 2000-12-22 1.43 STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
1GI3 2002-01-22 1.44 A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
5MNA 2017-05-24 1.44 Cationic trypsin in complex with aniline (deuterated sample at 295 K)
2G5V 2006-08-29 1.45 Indole-amidine Complexes with Bovine Trypsin
1O2Y 2003-09-02 1.45 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
5MNZ 2018-01-17 1.45 Neutron structure of cationic trypsin in its apo form
3PMJ 2011-11-23 1.45 Bovine trypsin variant X(tripleIle227) in complex with small molecule inhibitor
1O37 2003-09-02 1.45 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
4ABJ 2012-03-07 1.45 Co-complex structure of bovine trypsin with a modified Bowman-Birk inhibitor (IcA)SFTI-1(1,14), that was 1,5-disubstituted with 1,2,3- trizol to mimic a cis amide bond
1O2R 2003-09-02 1.45 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1O33 2003-09-02 1.46 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1O2X 2003-09-02 1.46 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1C5R 2000-12-22 1.47 STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
1C2I 2000-07-26 1.47 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1O2P 2003-05-13 1.47 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1C5V 2000-12-22 1.48 STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
5MO1 2018-02-28 1.49 Neutron structure of cationic trypsin in complex with benzylamine
1GI6 2002-01-22 1.49 A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
3URE 2012-05-23 1.49 Repack mutant (T181I, W199L, Q210I) of alpha-Lytic Protease
7BS1 2020-08-26 1.5 Bovine Pancreatic Trypsin with benzamidine (Room Temperature)
1O2I 2003-05-13 1.5 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1C2L 2000-07-26 1.5 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
5MO2 2018-02-28 1.5 Neutron structure of cationic trypsin in complex with N-amidinopiperidine
1O34 2003-09-02 1.5 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
3LJO 2010-10-06 1.5 Bovine trypsin in complex with UB-THR 11
1O2V 2003-09-02 1.5 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1GJ6 2002-04-27 1.5 ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS
2ULL 1997-07-07 1.5 MULTIPLE CONFORMATION STRUCTURE OF ALPHA-LYTIC PROTEASE AT 120 K
2J9N 2007-04-03 1.5 Robotically harvested Trypsin complexed with Benzamidine containing polypeptide mediated crystal contacts
1XUG 1998-12-16 1.5 TRYPSIN-BABIM-ZN+2, PH 8.2
1TAL 1997-04-01 1.5 ALPHA-LYTIC PROTEASE AT 120 K (SINGLE STRUCTURE MODEL)
1XUI 1998-11-11 1.5 TRYPSIN-KETO-BABIM, ZN+2-FREE, PH 8.2
2BTC 2000-01-19 1.5 BOVINE TRYPSIN IN COMPLEX WITH SQUASH SEED INHIBITOR (CUCURBITA PEPO TRYPSIN INHIBITOR II)
1O2Q 2003-09-02 1.5 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1TLD 1990-01-15 1.5 CRYSTAL STRUCTURE OF BOVINE BETA-TRYPSIN AT 1.5 ANGSTROMS RESOLUTION IN A CRYSTAL FORM WITH LOW MOLECULAR PACKING DENSITY. ACTIVE SITE GEOMETRY, ION PAIRS AND SOLVENT STRUCTURE
1O2N 2003-05-13 1.5 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
5MO0 2018-02-28 1.5 Neutron structure of cationic trypsin in complex with benzamidine
1BTY 1995-10-15 1.5 Crystal structure of beta-trypsin in complex with benzamidine
6T0M 2020-05-13 1.51 Cationic Trypsin in Complex with a D-Phe-Pro-diaminopyridine derivative
2G5N 2006-08-29 1.51 Indole-amidine Complexes with Bovine Trypsin
2ZFS 2009-01-13 1.51 Exploring trypsin S3 pocket
1O3I 2003-09-02 1.51 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
4ABG 2012-02-08 1.52 Fragments bound to bovine trypsin for the SAMPL challenge
3PLK 2011-12-07 1.53 Bovine trypsin variant X(tripleIle227) in complex with small molecule inhibitor
3PM3 2011-12-07 1.53 Bovine trypsin variant X(tripleIle227) in complex with small molecule inhibitor
1O3H 2003-09-02 1.53 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
3UPE 2012-11-21 1.54 Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor
5LH8 2016-08-10 1.54 Trypsin inhibitors for the treatment of pancreatitis - cpd 8
1O3G 2003-09-02 1.55 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
4ABI 2012-03-07 1.55 Co-complex structure of bovine trypsin with a modified Bowman-Birk inhibitor (PtA)SFTI-1(1,14), that was 1,4-disubstituted with a 1,2,3- trizol to mimic a trans amide bond
1O3O 2003-09-02 1.55 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
3ITI 2009-10-27 1.55 Structure of bovine trypsin with the MAD triangle B3C
3GY4 2010-03-23 1.55 A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC
3LJJ 2010-10-06 1.55 Bovine trypsin in complex with UB-THR 10
1O3F 2003-09-02 1.55 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
5T3H 2016-11-30 1.55 bovine trypsin soaked with selenourea for 5 min
2PTN 1982-03-04 1.55 ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY
3M7T 2011-02-09 1.55 Crystal Structure of Alpha-Lytic Protease SB2+3 E8A/R105S Mutant
1O30 2003-09-02 1.55 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1O3M 2003-09-02 1.55 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
2G81 2007-01-02 1.55 Crystal Structure of the Bowman-Birk Inhibitor from Vigna unguiculata Seeds in Complex with Beta-trypsin at 1.55 Angstrons Resolution
1O3N 2003-09-02 1.55 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
7BRV 2020-08-26 1.55 Bovine Pancreatic Trypsin with 4-Bromobenzamidine (Room Temperature)
3GY7 2010-03-23 1.55 A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC
2OTV 2007-02-27 1.56 Crystal structure of the complex formed between bovine trypsin and nicotinamide at 1.56 A resolution
2PLX 2007-08-07 1.56 Trypsin complexed to a synthetic peptide from Veronica hederifolia
3GY5 2010-03-23 1.57 A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC
2FX6 2006-02-14 1.57 bovine trypsin complexed with 2-aminobenzamidazole
3GY2 2010-03-23 1.57 A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC
2FI4 2006-01-24 1.58 Crystal structure of a BPTI variant (Cys14->Ser) in complex with trypsin
2FI5 2006-01-24 1.58 Crystal structure of a BPTI variant (Cys38->Ser) in complex with trypsin
2FI3 2006-01-24 1.58 Crystal structure of a BPTI variant (Cys14->Ser, Cys38->Ser) in complex with trypsin
1O39 2003-09-02 1.59 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1Y5U 2005-12-13 1.6 Dianhydrosugar-based benzamidine, factor Xa specific inhibitor in complex with bovine trypsin mutant
1P2K 2004-04-20 1.6 Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin
3RXI 2011-08-24 1.6 Crystal structure of Trypsin complexed with 2-(1H-indol-3-yl)ethanamine
7BRW 2020-08-26 1.6 Bovine Pancreatic Trypsin with 5-chlorotryptamine (Room Temperature)
3RXO 2011-08-24 1.6 Crystal structure of Trypsin complexed with (3-pyrrol-1-ylphenyl)methanamine
1QRX 1999-06-18 1.6 CRYSTAL STRUCTURE OF WILD-TYPE ALPHA-LYTIC PROTEASE AT 1.6 A, PH 5.14
3RXK 2011-08-24 1.6 Crystal structure of Trypsin complexed with methyl 4-amino-1-methyl-pyrrolidine-2-carboxylate
1GI5 2002-01-22 1.6 A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
4AB8 2012-02-08 1.6 Fragments bound to bovine trypsin for the SAMPL challenge
3PWC 2011-12-21 1.6 Bovine trypsin variant X(tripleGlu217Ile227) in complex with small molecule inhibitor
3RXP 2011-08-24 1.6 Crystal structure of Trypsin complexed with (1,5-dimethylpyrazol-3-yl)methanamine
1Y3V 2005-12-06 1.6 Trypsin Inhibitor Complex
1CT4 2000-01-12 1.6 CRYSTAL STRUCTURE OF THE OMTKY3 P1 VARIANT OMTKY3-VAL18I IN COMPLEX WITH SGPB
1V2L 2004-06-01 1.6 Benzamidine in complex with bovine trypsin variant X(triple.Glu)bT.D1
6E5M 2019-03-13 1.61 Crystallographic structure of the cyclic nonapeptide derived from the BTCI inhibitor bound to beta-trypsin in space group P 32 2 1
1O2T 2003-09-02 1.62 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
3UNQ 2012-11-21 1.62 Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor
2FTL 2006-02-14 1.62 Crystal structure of trypsin complexed with BPTI at 100K
1V2O 2004-06-01 1.62 Trypsin inhibitor in complex with bovine trypsin variant X(SSYI)bT.B4
3PLP 2011-12-07 1.63 Bovine trypsin variant X(tripleIle227) in complex with small molecule inhibitor
6QL0 2020-02-19 1.63 Cationic Trypsin in Complex with a D-Phe-Pro-p-aminopyridine derivative
3PWB 2011-12-21 1.63 Bovine trypsin variant X(tripleGlu217Ile227) in complex with small molecule inhibitor
1O2O 2003-05-13 1.63 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1C1S 2000-07-26 1.63 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1O2K 2003-05-13 1.63 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
3V13 2012-12-12 1.63 Bovine trypsin variant X(tripleGlu217Phe227) in complex with small molecule inhibitor
1O3C 2003-09-02 1.64 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1O3E 2003-09-02 1.64 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
3D65 2009-06-16 1.64 Crystal structure of Textilinin-1, a Kunitz-type serine protease inhibitor from the Australian Common Brown snake venom, in complex with trypsin
1SFI 1999-07-09 1.65 High resolution structure of a potent, cyclic protease inhibitor from sunflower seeds
1C2G 2000-07-26 1.65 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
2NU2 2006-11-21 1.65 Accommodation of positively-charged residues in a hydrophobic specificity pocket: Crystal structures of SGPB in complex with OMTKY3 variants Lys18I and Arg18I
1C2E 2000-07-26 1.65 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1TGN 1979-10-19 1.65 STRUCTURE OF BOVINE TRYPSINOGEN AT 1.9 ANGSTROMS RESOLUTION
1V2M 2004-06-01 1.65 Benzamidine in complex with bovine trypsin variant X(triple.Glu)bT.A1
2FTM 2006-02-14 1.65 Crystal structure of trypsin complexed with the BPTI variant (Tyr35->Gly)
1O2J 2003-05-13 1.65 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1P2I 2004-04-20 1.65 Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin
1O2S 2003-09-02 1.65 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1C2D 2000-07-26 1.65 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
2FX4 2006-02-14 1.65 Bovine trypsin bound by 4-piperidinebutyrate to make acylenzyme complex
1O2Z 2003-09-02 1.65 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1CT2 2000-01-12 1.65 CRYSTAL STRUCTURE OF THE OMTKY3 P1 VARIANT OMTKY3-THR18I IN COMPLEX WITH SGPB
1Y5B 2005-12-13 1.65 Dianhydrosugar-based benzamidine, factor Xa specific inhibitor in complex with bovine trypsin mutant
7BRY 2020-08-26 1.65 Bovine Pancreatic Trypsin with 6-Methoxytryptamine (Room Temperature)
1C2K 2000-07-26 1.65 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1O31 2003-09-02 1.66 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
2ZDK 2008-10-14 1.67 Exploring Trypsin S3 Pocket
3RXQ 2011-08-24 1.68 Crystal structure of Trypsin complexed with benzamide (F01 and F05, cocktail experiment)
2ZQ1 2009-08-04 1.68 Exploring trypsin S3 pocket
1O2L 2003-05-13 1.68 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
3RXU 2011-08-24 1.68 Crystal structure of Trypsin complexed with benzamide (F05 and A06, cocktail experiment)
3RU4 2012-08-29 1.68 Crystal structure of the Bowman-Birk serine protease inhibitor BTCI in complex with trypsin and chymotrypsin
1O2M 2003-05-13 1.69 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
3UOP 2012-11-21 1.69 Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor
2GKV 2007-02-13 1.7 Crystal structure of the SGPB:P14'-Ala32 OMTKY3-del(1-5) complex
3Q00 2011-12-21 1.7 Bovine trypsin variant X(tripleGlu217Ile227) in complex with small molecule inhibitor
3GY6 2010-03-23 1.7 A comparative study on the inhibition of bovine beta-trypsin by the bis-benzamidines diminazene and pentamidine
1C2F 2000-07-26 1.7 RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
1DS2 2001-01-31 1.7 CRYSTAL STRUCTURE OF SGPB:OMTKY3-COO-LEU18I
2O9Q 2007-12-25 1.7 The crystal structure of Bovine Trypsin complexed with a small inhibition peptide ORB2K
4AOR 2013-01-09 1.7 Cationic trypsin in complex with the Spinacia oleracea trypsin inhibitor III (SOTI-III)
3RXT 2011-08-24 1.7 Crystal structure of Trypsin complexed with (3-methoxyphenyl)methanamin (F04 and F03, cocktail experiment)
1TGT 1982-03-04 1.7 ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY
3RXB 2011-08-24 1.7 Crystal structure of Trypsin complexed with 4-guanidinobutanoic acid
3RXG 2011-08-24 1.7 Crystal structure of Trypsin complexed with 4-aminocyclohexanol
1TX8 2005-10-18 1.7 Bovine Trypsin complexed with AMSO
1V2R 2004-06-01 1.7 Trypsin inhibitor in complex with bovine trypsin variant X(SSRI)bT.B4
3GY3 2010-03-23 1.7 A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC
3PTB 1983-01-18 1.7 THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS
3RXJ 2011-08-24 1.7 Crystal structure of Trypsin complexed with 4-guanidinobenzoic acid
3AAV 2010-04-07 1.7 Bovine beta-trypsin bound to meta-diamidino schiff base copper (II) chelate
1Y3X 2005-12-06 1.7 TRYPSIN INHIBITOR COMPLEX
1JRT 1996-10-14 1.7 HEMIACETAL COMPLEX BETWEEN LEUPEPTIN AND TRYPSIN
5K7R 2017-04-05 1.7 MicroED structure of trypsin at 1.7 A resolution
3RXV 2011-08-24 1.7 Crystal structure of Trypsin complexed with benzamide (F05 and F03, cocktail experiment)
1BTX 1995-10-15 1.7 Episelection: Novel Ki ~Nanomolar Inhibitors of Serine Proteases Selected by Binding or Chemistry on an Enzyme Surface
3RXL 2011-08-24 1.7 Crystal structure of Trypsin complexed with (2,5-dimethyl-3-furyl)methanamine
3RXC 2011-08-24 1.7 Crystal structure of Trypsin complexed with 2-aminopyridine
2TGT 1982-03-04 1.7 ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY
3T25 2011-12-28 1.7 TMAO-grown orthorhombic trypsin (bovine)
3RXE 2011-08-24 1.7 Crystal structure of Trypsin complexed with benzamide
3RXM 2011-08-24 1.7 Crystal structure of Trypsin complexed with [2-(2-thienyl)thiazol-4-yl]methanamine
2ALP 1985-07-17 1.7 REFINED STRUCTURE OF ALPHA-LYTIC PROTEASE AT 1.7 ANGSTROMS RESOLUTION. ANALYSIS OF HYDROGEN BONDING AND SOLVENT STRUCTURE
3M7Q 2011-03-16 1.7 Crystal structure of recombinant Kunitz Type serine protease Inhibitor-1 from the Caribbean sea anemone stichodactyla helianthus in complex with bovine pancreatic trypsin
3RXF 2011-08-24 1.7 Crystal structure of Trypsin complexed with 4-aminopyridine
1TPO 1983-01-18 1.7 THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS
3RXA 2011-08-24 1.7 Crystal structure of Trypsin complexed with cycloheptanamine
3T26 2011-12-28 1.7 Orthorhombic trypsin (bovine) in the presence of sarcosine
3PTN 1982-03-04 1.7 ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY
1O36 2003-09-02 1.7 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1RXP 2004-06-08 1.7 STRUCTURE OF TRYPSIN (ORTHORHOMBIC) WITH 1-(4-TERT-BUTYLCARBAMOYL- PIPERAZINE-1-CARBONYL)-3-(3-GUANIDINO-PROPYL)-4-OXO-AZETIDINE-2-CARBOXYLIC ACID
1BTW 1995-10-15 1.7 Episelection: novel KI ~nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface
3RXH 2011-08-24 1.7 Crystal structure of Trypsin complexed with 2-(1H-imidazol-4-yl)ethanamine
3RXD 2011-08-24 1.7 Crystal structure of Trypsin complexed with (3-methoxyphenyl)methanamine
3ATI 2011-08-24 1.71 Crystal structure of trypsin complexed with (3-methoxyphenyl)methanamine
3ATM 2011-08-24 1.72 Crystal structure of trypsin complexed with 2-(1H-indol-3-yl)ethanamine
1V2S 2004-06-01 1.72 Benzamidine in complex with bovine trypsin variant X(SSFI.Glu)bT.D1
3RXR 2011-08-24 1.72 Crystal structure of Trypsin complexed with cycloheptanamine (F01 and F03, cocktail experiment)
3ATL 2011-08-24 1.74 Crystal structure of trypsin complexed with benzamidine
3ATK 2011-08-24 1.74 Crystal structure of trypsin complexed with cycloheptanamine
3RXS 2011-08-24 1.74 Crystal structure of Trypsin complexed with (3-methoxyphenyl)methanamine (F04 and A06, cocktail experiment)
3A8D 2010-09-29 1.75 Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid (under aniline-free condition)
2SGF 2003-08-26 1.75 PHE 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B
3GY8 2010-03-23 1.75 A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC
3A7V 2010-09-29 1.75 Crystal Structure of Trypsin complexed with 3-formylbenzimidamide
1O3B 2003-09-02 1.75 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
3A82 2010-09-29 1.75 Crystal Structure of Trypsin complexed with pre-synthesized (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid
3A80 2010-09-29 1.75 Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)-2-methylpropanoic acid (soaking 40seconds)
3AAS 2010-04-07 1.75 Bovine beta-trypsin bound to meta-guanidino schiff base copper (II) chelate
3A87 2010-09-29 1.75 Crystal Structure of Trypsin complexed with (E)-4-((2-nicotinoylhydrazono)methyl)benzimidamide (soaking 5 minutes)
1TX7 2005-09-20 1.75 Bovine Trypsin complexed with p-amidinophenylmethylphosphinic acid (AMPA)
3BTH 2000-03-13 1.75 THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
3A8B 2010-09-29 1.75 Crystal Structure of Trypsin complexed with (E)-4-((4-bromophenylimino)methyl)benzimidamide
3A7X 2010-09-29 1.75 Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid (soaking 45seconds)
3A85 2010-09-29 1.75 Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid (soaking 15 seconds)
3A88 2010-09-29 1.75 Crystal Structure of Trypsin complexed with (E)-4-((2-nicotinoylhydrazono)methyl)benzimidamide (soaking 30 minutes)
1V2W 2004-06-01 1.75 Trypsin inhibitor in complex with bovine trypsin variant X(SSAI)bT.B4
3A84 2010-09-29 1.75 Crystal Structure of Trypsin complexed with(E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid (soaking 5 seconds)
1Y3Y 2005-12-06 1.75 TRYPSIN INHIBITOR COMPLEX
3T29 2011-12-28 1.75 TMAO-grown trigonal trypsin (bovine)
2NU4 2006-11-21 1.75 Accommodation of positively-charged residues in a hydrophobic specificity pocket: Crystal structures of SGPB in complex with OMTKY3 variants Lys18I and Arg18I
3A7W 2010-09-29 1.75 Crystal Structure of Trypsin complexed with (E)-4-((tetrahydro-2H-pyran-2-yloxyimino)methyl)benzimidamide (soaking 4hours)
3A7T 2010-09-29 1.75 Crystal Structure of Trypsin complexed with 4-formylbenzimidamide
3A86 2010-09-29 1.75 Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid (soaking 30 seconds)
2ZFT 2009-01-13 1.76 Exploring trypsin S3 pocket
1O2H 2003-05-13 1.77 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
5FXL 2016-03-16 1.78 Structure of trypsin solved by MR from data collected by Direct Data Collection (DDC) using the ESRF RoboDiff goniometer
3A83 2010-09-29 1.78 Crystal Structure of Trypsin complexed with pre-synthesized (E)-4-((2-nicotinoylhydrazono)methyl)benzimidamide
4B1T 2012-08-01 1.78 Structure of the factor Xa-like trypsin variant triple-Ala (TA) in complex with eglin C
3A81 2010-09-29 1.78 Crystal Structure of Trypsin complexed with (E)-4-((2-nicotinoylhydrazono)methyl)benzimidamide (soaking 8 hours)
1O32 2003-09-02 1.78 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1F2S 2000-06-05 1.79 CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN BOVINE BETA-TRYPSIN AND MCTI-A, A TRYPSIN INHIBITOR OF SQUASH FAMILY AT 1.8 A RESOLUTION
1TNJ 1994-11-30 1.8 PREDICTION OF NOVEL SERINE PROTEASE INHIBITORS
3SGQ 2003-08-26 1.8 GLN 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B AT PH 10.7
1SGN 2003-08-26 1.8 ASN 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B
3A89 2010-09-29 1.8 Crystal Structure of Trypsin complexed with (E)-4-((2-nicotinoylhydrazono)methyl)benzimidamide (soaking 4 hours)
1TGB 1979-06-13 1.8 CRYSTAL STRUCTURE OF BOVINE TRYPSINOGEN AT 1.8 ANGSTROMS RESOLUTION. II. CRYSTALLOGRAPHIC REFINEMENT, REFINED CRYSTAL STRUCTURE AND COMPARISON WITH BOVINE TRYPSIN
1V2N 2004-06-01 1.8 Potent factor XA inhibitor in complex with bovine trypsin variant X(99/175/190)bT
2SGP 2001-01-31 1.8 PRO 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B AT PH 6.5
3UQO 2012-11-21 1.8 Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor
1TNH 1994-11-30 1.8 PREDICTION OF NOVEL SERINE PROTEASE INHIBITORS
1SGD 2003-08-26 1.8 ASP 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B AT PH 6.5
1QBO 2000-05-03 1.8 BOVINE TRYPSIN 7-[[6-[[1-(1-IMINOETHYL)PIPERIDIN-4-YL]OXY]-2-METHYL-BENZIMIDAZOL-1-YL]METHYL]NAPHTHALENE-2-CARBOXIMIDAMID ZK-806711 INHIBITOR COMPLEX
1QB1 2000-04-29 1.8 Bovine Trypsin with 1-[2-[5-[amino(imino)methyl]-2-hydroxyphenoxy]-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]piperidine-3-carboxylic Acid (ZK-806974)
1V2V 2004-06-01 1.8 Benzamidine in complex with bovine trypsin variant X(SSAI)bT.C1
1BJV 1998-12-02 1.8 BETA-TRYPSIN COMPLEXED WITH APPU
1JRS 1996-10-14 1.8 HEMIACETAL COMPLEX BETWEEN LEUPEPTIN AND TRYPSIN
1SGY 2003-08-26 1.8 TYR 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B AT PH 6.5
1TNG 1994-11-30 1.8 PREDICTION OF NOVEL SERINE PROTEASE INHIBITORS
1Y3W 2005-12-06 1.8 TRYPSIN INHIBITOR COMPLEX
3BTF 2000-03-13 1.8 THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI.
1BJU 1998-12-02 1.8 BETA-TRYPSIN COMPLEXED WITH ACPU
3AAU 2010-04-07 1.8 Bovine beta-trypsin bound to meta-diguanidino schiff base copper (II) chelate
1NTP 1988-01-16 1.8 USE OF THE NEUTRON DIFFRACTION H/D EXCHANGE TECHNIQUE TO DETERMINE THE CONFORMATIONAL DYNAMICS OF TRYPSIN
1G3D 2001-01-17 1.8 BOVINE BETA-TRYPSIN BOUND TO META-AMIDINO SCHIFF BASE COPPER (II) CHELATE
2TGA 1982-03-04 1.8 ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY
2SGQ 2003-08-26 1.8 GLN 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B AT PH 6.5
1QCP 1999-05-21 1.8 CRYSTAL STRUCTURE OF THE RWJ-51084 BOVINE PANCREATIC BETA-TRYPSIN AT 1.8 A
1QA0 2000-04-10 1.8 BOVINE TRYPSIN 2-AMINOBENZIMIDAZOLE COMPLEX
1F0T 2000-09-20 1.8 BOVINE TRYPSIN COMPLEXED WITH RPR131247
1MAX 1996-10-14 1.8 BETA-TRYPSIN PHOSPHONATE INHIBITED
1SBW 1999-05-06 1.8 CRYSTAL STRUCTURE OF MUNG BEAN INHIBITOR LYSINE ACTIVE FRAGMENT COMPLEX WITH BOVINE BETA-TRYPSIN AT 1.8A RESOLUTION
1XUK 1998-11-11 1.8 TRYPSIN-BABIM-SULFATE, PH 5.9
2SGD 2003-08-26 1.8 ASP 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B AT PH 10.7
3BTM 2000-03-13 1.8 THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
3A7Z 2010-09-29 1.8 Crystal Structure of Trypsin complexed with (E)-4-((1-methylpiperidin-4-yloxyimino)methyl)benzimidamide (soaking 3hours)
1MAY 1996-10-14 1.8 BETA-TRYPSIN PHOSPHONATE INHIBITED
1SGR 1995-10-15 1.8 LEU 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B
1SGE 2003-08-26 1.8 GLU 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B AT PH 6.5
3SGB 1983-07-12 1.8 STRUCTURE OF THE COMPLEX OF STREPTOMYCES GRISEUS PROTEASE B AND THE THIRD DOMAIN OF THE TURKEY OVOMUCOID INHIBITOR AT 1.8 ANGSTROMS RESOLUTION
1TGS 1983-01-18 1.8 THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX BETWEEN PANCREATIC SECRETORY INHIBITOR (KAZAL TYPE) AND TRYPSINOGEN AT 1.8 ANGSTROMS RESOLUTION. STRUCTURE SOLUTION, CRYSTALLOGRAPHIC REFINEMENT AND PRELIMINARY STRUCTURAL INTERPRETATION
1G3E 2001-01-17 1.8 BOVINE BETA-TRYPSIN BOUND TO PARA-AMIDINO SCHIFF-BASE COPPER (II) CHELATE
1PPC 1994-01-31 1.8 GEOMETRY OF BINDING OF THE BENZAMIDINE-AND ARGININE-BASED INHIBITORS N-ALPHA-(2-NAPHTHYL-SULPHONYL-GLYCYL)-DL-P-AMIDINOPHENYLALANYL-PIPERIDINE (NAPAP) AND (2R,4R)-4-METHYL-1-[N-ALPHA-(3-METHYL-1,2,3,4-TETRAHYDRO-8-QUINOLINESULPHONYL)-L-ARGINYL]-2-PIPERIDINE CARBOXYLIC ACID (MQPA) TO HUMAN ALPHA-THROMBIN: X-RAY CRYSTALLOGRAPHIC DETERMINATION OF THE NAPAP-TRYPSIN COMPLEX AND MODELING OF NAPAP-THROMBIN AND MQPA-THROMBIN
1TGC 1982-03-04 1.8 ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY
3PRO 1999-04-27 1.8 ALPHA-LYTIC PROTEASE COMPLEXED WITH C-TERMINAL TRUNCATED PRO REGION
1V2U 2004-06-01 1.8 Benzamidine in complex with bovine trypsin varinat X(SSAI)bT.D1
1AZ8 1999-01-13 1.8 BOVINE TRYPSIN COMPLEXED TO BIS-PHENYLAMIDINE INHIBITOR
2ZDL 2008-10-14 1.8 Exploring trypsin S3 pocket
1G3C 2001-01-17 1.8 BOVINE BETA-TRYPSIN BOUND TO PARA-AMIDINO SCHIFF BASE IRON(III) CHELATE
1TNK 1994-11-30 1.8 PREDICTION OF NOVEL SERINE PROTEASE INHIBITORS
1ZR0 2005-06-07 1.8 Crystal Structure of Kunitz Domain 1 of Tissue Factor Pathway Inhibitor-2 with Bovine Trypsin
1Y3U 2005-12-06 1.8 TRYPSIN INHIBITOR COMPLEX
2NU3 2006-11-21 1.8 Accommodation of positively-charged residues in a hydrophobic specificity pocket: Crystal structures of SGPB in complex with OMTKY3 variants Lys18I and Arg18I
1QBN 2000-05-03 1.8 Bovine Trypsin 2-[amino(imino)methyl]-2-hydroxyphenoxy]-6-[3-(4,5-dihydro-1H-imidazol-2-yl)phenoxy]pyridine-4-carboxylic Acid (ZK-806688) Complex
7BS2 2020-08-26 1.8 Bovine Pancreatic Trypsin with serotonin (Room Temperature)
2NU1 2006-11-21 1.8 Molecular structures of the complexes of SGPB with OMTKY3 aromatic P1 variants Trp18I, His18I, Phe18I and Tyr18I
3V12 2012-12-12 1.8 Bovine trypsin variant X(tripleGlu217Phe227) in complex with small molecule inhibitor
1QB6 2000-04-29 1.8 BOVINE TRYPSIN 3,3'-[3,5-DIFLUORO-4-METHYL-2, 6-PYRIDINEDIYLBIS(OXY)]BIS(BENZENECARBOXIMIDAMIDE) (ZK-805623) COMPLEX
2SGE 2003-08-26 1.8 GLU 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B AT PH 10.7
1G3B 2001-01-17 1.8 BOVINE BETA-TRYPSIN BOUND TO META-AMIDINO SCHIFF BASE MAGNESIUM(II) CHELATE
4GUX 2013-09-04 1.8 Crystal structure of trypsin:MCoTi-II complex
1QB9 2000-04-30 1.8 BOVINE TRYPSIN 7-[[2-[[1-(1-IMINOETHYL)PIPERIDIN-4-YL]OXY]-9H-CARBOZOL-9-YL] METHYL]NAPHTHALENE-2-CARBOXIMIDAMIDE (ZK-806450) COMPLEX
1CT0 2000-01-12 1.8 CRYSTAL STRUCTURE OF THE OMTKY3 P1 VARIANT OMTKY3-SER18I IN COMPLEX WITH SGPB
3UNS 2012-11-21 1.8 Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor
1TAW 1997-06-24 1.8 BOVINE TRYPSIN COMPLEXED TO APPI
3A7Y 2010-09-29 1.81 Crystal Structure of Trypsin complexed with (E)-4-((1-methylpiperidin-3-yloxyimino)methyl)benzimidamide (soaking 2hours)
2G55 2007-02-20 1.82 Anomalous substructure of trypsin (P3121)
3BTE 2000-03-15 1.85 The Crystal Structures of the Complexes Between Bovine Beta-Trypsin and Ten P1 Variants of BPTI.
7BS0 2020-08-26 1.85 Bovine Pancreatic Trypsin with aniline (Room Temperature)
1EJM 2001-03-03 1.85 CRYSTAL STRUCTURE OF THE BPTI ALA16LEU MUTANT IN COMPLEX WITH BOVINE TRYPSIN
3BTK 2000-03-13 1.85 THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
3A8C 2010-09-29 1.85 Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid (soaking with mixture of [(E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid] and [(E)-2-(4-carbamimidoylbenzylideneaminooxy)-2-methylpropanoic acid])
4B2A 2012-08-01 1.89 Structure of the factor Xa-like trypsin variant triple-Ala (TGA) in complex with eglin C
3BTQ 2000-03-15 1.9 THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
1MTS 1997-08-20 1.9 FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
3BTG 2000-03-13 1.9 THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
1SGQ 1995-10-15 1.9 GLY 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B
1V2J 2004-06-01 1.9 BENZAMIDINE IN COMPLEX WITH BOVINE TRYPSIN VARIANT X(SSRI)bT.C1
2BZA 1999-03-23 1.9 BOVINE PANCREAS BETA-TRYPSIN IN COMPLEX WITH BENZYLAMINE
1CE5 1999-03-23 1.9 BOVINE PANCREAS BETA-TRYPSIN IN COMPLEX WITH BENZAMIDINE
1CSO 2000-01-12 1.9 CRYSTAL STRUCTURE OF THE OMTKY3 P1 VARIANT OMTKY3-ILE18I IN COMPLEX WITH SGPB
1G36 2001-10-23 1.9 TRYPSIN INHIBITOR COMPLEX
3TPI 1983-01-18 1.9 THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS
1K1P 2001-11-28 1.9 BOVINE TRYPSIN-INHIBITOR COMPLEX
1MTU 1997-11-12 1.9 FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
3BTD 2000-03-13 1.9 The Crystal Structures of the Complexes Between the Bovine Beta-Trypsin and Ten P1 Variants of BPTI.
1TNL 1994-11-30 1.9 PREDICTION OF NOVEL SERINE PROTEASE INHIBITORS
1F0U 2000-09-20 1.9 BOVINE TRYPSIN COMPLEXED WITH RPR128515
1ZZZ 1999-06-15 1.9 Trypsin inhibitors with rigid tripeptidyl aldehydes
2PTC 1983-01-18 1.9 THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS
3V0X 2012-12-12 1.9 Bovine trypsin variant X(tripleGlu217Phe227) in complex with small molecule inhibitor
1XUF 1998-12-16 1.9 TRYPSIN-BABIM-ZN+2, PH 8.2
1PPH 1994-01-31 1.9 GEOMETRY OF BINDING OF THE NALPHA-TOSYLATED PIPERIDIDES OF M-AMIDINO-, P-AMIDINO-AND P-GUANIDINO PHENYLALANINE TO THROMBIN AND TRYPSIN: X-RAY CRYSTAL STRUCTURES OF THEIR TRYPSIN COMPLEXES AND MODELING OF THEIR THROMBIN COMPLEXES
1TNI 1994-11-30 1.9 PREDICTION OF NOVEL SERINE PROTEASE INHIBITORS
3BTT 2000-03-13 1.9 THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
1V2T 2004-06-01 1.9 Trypsin inhibitor in complex with bovine trypsin variant X(SSFI.Glu)bT.B4
1OYQ 2003-04-29 1.9 TRYPSIN INHIBITOR COMPLEX
1TPS 1995-01-26 1.9 ATOMIC STRUCTURE OF THE TRYPSIN-A90720A COMPLEX: A UNIFIED APPROACH TO STRUCTURE AND FUNCTION
1TPA 1983-01-18 1.9 THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS
1MTW 1997-11-12 1.9 FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
1NC6 2003-09-23 1.9 Potent, small molecule inhibitors of human mast cell tryptase. Anti-asthmatic action of a dipeptide-based transition state analogue containing benzothiazole ketone
2TGP 1983-01-18 1.9 THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS
1P12 1993-01-15 1.9 CRYSTAL STRUCTURES OF ALPHA-LYTIC PROTEASE COMPLEXES WITH IRREVERSIBLY BOUND PHOSPHONATE ESTERS
1MTV 1997-11-12 1.9 FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
5JYI 2016-07-06 1.91 Trypsin bound with succinic acid at 1.9A
1XUJ 1998-11-11 1.92 TRYPSIN-KETO-BABIM-ZN+2, PH 8.2
1V2P 2004-06-01 1.92 Trypsin inhibitor in complex with bovine trypsin variant X(SSYI)bT.A4
6BVH 2018-12-19 1.93 Trypsin complexed with a modified sunflower trypsin inhibitor, SFTI-TCTR(N12,N14)
2TIO 1998-09-30 1.93 LOW PACKING DENSITY FORM OF BOVINE BETA-TRYPSIN IN CYCLOHEXANE
1P11 1993-01-15 1.93 CRYSTAL STRUCTURES OF ALPHA-LYTIC PROTEASE COMPLEXES WITH IRREVERSIBLY BOUND PHOSPHONATE ESTERS
1TIO 1998-09-23 1.93 HIGH PACKING DENSITY FORM OF BOVINE BETA-TRYPSIN IN CYCLOHEXANE
2ZDM 2008-10-14 1.93 Exploring trypsin S3 pocket
3VPK 2012-05-23 1.94 Crystal Structure of 6-Guanidinohexanoyl Trypsin
2ZHD 2009-02-10 1.94 Exploring trypsin S3 pocket
6DWF 2019-01-30 1.94 Crystal structure of complex of BBKI mutant, L55R with Bovine Trypsin
2NU0 2006-11-21 1.95 Molecular structures of the complexes of SGPB with OMTKY3 aromatic P1 variants Trp18I, His18I, Phe18I, and Tyr18I
3T27 2011-12-28 1.95 Orthorhombic trypsin (bovine) in the presence of betaine
2ZDN 2008-10-14 1.98 Exploring trypsin S3 pocket
1P01 1990-04-15 2.0 Serine protease mechanism. structure of an inhibitory complex oF ALPHA-LYTIC Protease and a tightly bound peptide boronic acid
4AOQ 2013-01-09 2.0 Cationic trypsin in complex with mutated Spinacia oleracea trypsin inhibitor III (SOTI-III) (F14A)
1BTZ 1995-10-15 2.0 Episelection: novel KI ~nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface
1V2K 2004-06-01 2.0 Factor XA specific Inhibitor in complex with bovine trypsin variant X(triple.Glu)bT.D2
6AVL 2017-09-20 2.0 Orthorhombic Trypsin (295 K) in the presence of 50% xylose
1TYN 1995-01-26 2.0 ATOMIC STRUCTURE OF THE TRYPSIN-CYCLOTHEONAMIDE A COMPLEX: LESSONS FOR THE DESIGN OF SERINE PROTEASE INHIBITORS
6DWH 2019-01-30 2.0 Crystal structure of complex of BBKI and Bovine Trypsin
1K1N 2001-11-28 2.0 BOVINE TRYPSIN-INHIBITOR COMPLEX
6B6S 2017-11-01 2.0 Orthorhombic trypsin cryocooled to 100 K with 50% ethanol as cryoprotectant
6B6P 2017-11-01 2.0 Orthorhombic trypsin cryocooled to 100 K with 30% xylose as cryoprotectant
4J2Y 2013-05-08 2.0 Crystal structure of a plant trypsin inhibitor EcTI in complex with bovine trypsin.
6B6Q 2017-11-01 2.0 Orthorhombic trypsin cryocooled to 100 K with 50% xylose as cryoprotectant
1JIR 2001-07-18 2.0 Crystal Structure of Trypsin Complex with Amylamine in Cyclohexane
2ILN 2007-04-10 2.0 Crystal structure of the Bowman-Birk inhibitor from snail medic seeds in complex with bovine trypsin
6B6T 2018-03-14 2.0 Orthorhombic trypsin cryocooled to 100 K with 50% methanol as cryoprotectant
1K1O 2001-11-28 2.0 BOVINE TRYPSIN-INHIBITOR COMPLEX
6B6R 2017-11-01 2.0 Orthorhombic trypsin cryocooled to 100 K with 50% mpd as cryoprotectant
2D8W 2006-07-11 2.0 Structure of HYPER-VIL-trypsin
1GBT 1994-01-31 2.0 STRUCTURE OF AN ACYL-ENZYME INTERMEDIATE DURING CATALYSIS: (GUANIDINOBENZOYL) TRYPSIN
1EB2 2002-02-11 2.0 Trypsin inhibitor complex (BPO)
1OX1 2004-05-18 2.0 crystal structure of the bovine trypsin complex with a synthetic 11 peptide inhibitor
3PYH 2011-12-21 2.0 Bovine trypsin variant X(tripleGlu217Ile227) in complex with small molecule inhibitor
6B6N 2017-11-01 2.0 Orthorhombic trypsin (295 K) in the presence of 50% mpd
1PPE 1994-01-31 2.0 THE REFINED 2.0 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN BOVINE BETA-TRYPSIN AND CMTI-I, A TRYPSIN INHIBITOR FROM SQUASH SEEDS (CUCURBITA MAXIMA): TOPOLOGICAL SIMILARITY OF THE SQUASH SEED INHIBITORS WITH THE CARBOXYPEPTIDASE A INHIBITOR FROM POTATOES
1GBJ 1996-01-29 2.0 ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA
1O3A 2003-09-02 2.0 Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
1P02 1990-04-15 2.0 STRUCTURE ANALYSIS OF SPECIFICITY. ALPHA-LYTIC PROTEASE COMPLEXES WITH ANALOGUES OF REACTION INTERMEDIATES
7LPR 1993-01-15 2.05 STRUCTURAL BASIS FOR BROAD SPECIFICITY IN ALPHA-LYTIC PROTEASE MUTANTS
3BTW 2000-03-13 2.05 THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI
3QK1 2011-03-23 2.08 Crystal Structure of Enterokinase-like Trypsin Variant
2A7H 2005-07-19 2.1 On the Routine Use of Soft X-Rays in Macromolecular Crystallography, Part III- The Optimal Data Collection Wavelength
3UUZ 2012-12-05 2.1 Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor
1QL7 2000-08-25 2.1 FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
1AUJ 1998-10-14 2.1 BOVINE TRYPSIN COMPLEXED TO META-CYANO-BENZYLIC INHIBITOR
4SGB 1990-07-15 2.1 STRUCTURE OF THE COMPLEX OF STREPTOMYCES GRISEUS PROTEINASE B AND POLYPEPTIDE CHYMOTRYPSIN INHIBITOR-1 FROM RUSSET BURBANK POTATO TUBERS AT 2.1 ANGSTROMS RESOLUTION
1YP9 2006-01-17 2.1 Trypsin Inhibitor Complex
1YYY 1999-06-08 2.1 Trypsin inhibitors with rigid tripeptidyl aldehydes
2TGD 1986-05-07 2.1 LACK OF THE TRANSITION STATE STABILIZATION SITE IS A FACTOR IN THE INACTIVITY OF TRYPSINOGEN, A SERINE PROTEASE ZYMOGEN. STRUCTURE OF DFP INHIBITED BOVINE TRYPSINOGEN AT 2.1 ANGSTROMS RESOLUTION
2TPI 1982-03-04 2.1 ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY
6LPR 1993-01-15 2.1 STRUCTURAL BASIS FOR BROAD SPECIFICITY IN ALPHA-LYTIC PROTEASE MUTANTS
1BOQ 1998-08-12 2.1 PRO REGION C-TERMINUS: PROTEASE ACTIVE SITE INTERACTIONS ARE CRITICAL IN CATALYZING THE FOLDING OF ALPHA-LYTIC PROTEASE
1SMF 1994-07-31 2.1 Studies on an artificial trypsin inhibitor peptide derived from the mung bean inhibitor
1P05 1990-04-15 2.1 STRUCTURE ANALYSIS OF SPECIFICITY. ALPHA-LYTIC PROTEASE COMPLEXES WITH ANALOGUES OF REACTION INTERMEDIATES
1GBK 1996-01-29 2.13 ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA COMPLEX WITH METHOXYSUCCINYL-ALA-ALA-PRO-ALANINE BORONIC ACID
5LPR 1993-01-15 2.13 STRUCTURAL BASIS FOR BROAD SPECIFICITY IN ALPHA-LYTIC PROTEASE MUTANTS
1GBA 1996-01-29 2.15 ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA AND GLY 216 REPLACED BY ALA
3LPR 1993-01-15 2.15 STRUCTURAL BASIS FOR BROAD SPECIFICITY IN ALPHA-LYTIC PROTEASE MUTANTS
1GBB 1996-01-29 2.15 Alpha-lytic protease with met 190 replaced by ALA AND GLY 216 replaced by ALA complex with METHOXYSUCCINYL-ALA-ALA-PRO-ALANINE BORONIC ACID
1P03 1990-04-15 2.15 STRUCTURE ANALYSIS OF SPECIFICITY. ALPHA-LYTIC PROTEASE COMPLEXES WITH ANALOGUES OF REACTION INTERMEDIATES
1GBL 1996-01-29 2.15 ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA COMPLEX WITH METHOXYSUCCINYL-ALA-ALA-PRO-LEUCINE BORONIC ACID
1GBF 1996-01-29 2.15 ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA AND GLY 216 REPLACED BY LEU COMPLEX WITH METHOXYSUCCINYL-ALA-ALA-PRO-ALANINE BORONIC ACID
3M35 2010-04-21 2.2 Trypsin in complex with the inhibitor 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423)
1K1M 2001-11-28 2.2 BOVINE TRYPSIN-INHIBITOR COMPLEX
4TPI 1985-11-08 2.2 THE REFINED 2.2-ANGSTROMS (0.22-NM) X-RAY CRYSTAL STRUCTURE OF THE TERNARY COMPLEX FORMED BY BOVINE TRYPSINOGEN, VALINE-VALINE AND THE ARG15 ANALOGUE OF BOVINE PANCREATIC TRYPSIN INHIBITOR
1AQ7 1998-02-25 2.2 TRYPSIN WITH INHIBITOR AERUGINOSIN 98-B
1LQE 2003-05-10 2.2 CRYSTAL STRUCTURE OF TRYPSIN IN COMPLEX WITH 79.
1G9I 2000-12-06 2.2 CRYSTAL STRUCTURE OF BETA-TRYSIN COMPLEX IN CYCLOHEXANE
1K1I 2001-11-28 2.2 BOVINE TRYPSIN-INHIBITOR COMPLEX
1GBD 1996-01-29 2.2 ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA AND GLY 216 REPLACED BY ALA COMPLEX WITH METHOXYSUCCINYL-ALA-ALA-PRO-PHENYLALANINE BORONIC ACID
1BTP 1996-01-29 2.2 UNIQUE BINDING OF A NOVEL SYNTHETIC INHIBITOR, N-[3-[4-[4-(AMIDINOPHENOXY)-CARBONYL]PHENYL]-2-METHYL-2-PROPENOYL]-N-ALLYLGLYCINE METHANESULFONATE TO BOVINE TRYPSIN, REVEALED BY THE CRYSTAL STRUCTURE OF THE COMPLEX
1P09 1990-04-15 2.2 STRUCTURAL PLASTICITY AS A DETERMINANT OF ENZYME SPECIFICITY. CREATING BROADLY SPECIFIC PROTEASES
1K1J 2001-11-28 2.2 BOVINE TRYPSIN-INHIBITOR COMPLEX
1XUH 1998-11-11 2.2 TRYPSIN-KETO-BABIM-CO+2, PH 8.2
1GBH 1996-01-29 2.2 ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA AND GLY 216 REPLACED BY LEU COMPLEX WITH METHOXYSUCCINYL-ALA-ALA-PRO-LEUCINE BORONIC ACID
6FID 2018-02-07 2.2 Bovine trypsin solved by S-SAD on ID30B
9LPR 1993-01-15 2.2 STRUCTURAL BASIS FOR BROAD SPECIFICITY IN ALPHA-LYTIC PROTEASE MUTANTS
6DZF 2018-09-19 2.2 Orthorhombic trypsin cryocooled to 100 K with 20% xylose as cryoprotectant
1GBC 1996-01-29 2.2 ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA AND GLY 216 REPLACED BY ALA COMPLEX WITH METHOXYSUCCINYL-ALA-ALA-PRO-LEUCINE BORONIC ACID
1P10 1990-04-15 2.25 STRUCTURAL PLASTICITY AS A DETERMINANT OF ENZYME SPECIFICITY. CREATING BROADLY SPECIFIC PROTEASES
2CMY 2007-05-22 2.25 Crystal complex between bovine trypsin and Veronica hederifolia trypsin inhibitor
3VEQ 2012-10-03 2.25 A binary complex betwwen bovine pancreatic trypsin and a engineered mutant trypsin inhibitor
2LPR 1993-01-15 2.25 STRUCTURAL BASIS FOR BROAD SPECIFICITY IN ALPHA-LYTIC PROTEASE MUTANTS
8LPR 1993-01-15 2.25 STRUCTURAL BASIS FOR BROAD SPECIFICITY IN ALPHA-LYTIC PROTEASE MUTANTS
3RDZ 2011-07-06 2.26 Crystal Structure of rBTI-trypsin complex at 2.26 angstrom resolution
1GBM 1996-01-29 2.28 ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA COMPLEX WITH METHOXYSUCCINYL-ALA-ALA-PRO-PHENYLALANINE BORONIC ACID
1GBE 1996-01-29 2.3 ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA AND GLY 216 REPLACED BY LEU
1D6R 2000-05-05 2.3 CRYSTAL STRUCTURE OF CANCER CHEMOPREVENTIVE BOWMAN-BIRK INHIBITOR IN TERNARY COMPLEX WITH BOVINE TRYPSIN AT 2.3 A RESOLUTION. STRUCTURAL BASIS OF JANUS-FACED SERINE PROTEASE INHIBITOR SPECIFICITY
1V2Q 2004-06-01 2.3 Trypsin inhibitor in complex with bovine trypsin variant X(SSWI)bT.B4
1TAB 1992-01-15 2.3 STRUCTURE OF THE TRYPSIN-BINDING DOMAIN OF BOWMAN-BIRK TYPE PROTEASE INHIBITOR AND ITS INTERACTION WITH TRYPSIN
1GBI 1996-01-29 2.3 ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA AND GLY 216 REPLACED BY LEU COMPLEX WITH METHOXYSUCCINYL-ALA-ALA-PRO-PHENYLALANINE BORONIC ACID
1OPH 2003-08-05 2.3 NON-COVALENT COMPLEX BETWEEN ALPHA-1-PI-PITTSBURGH AND S195A TRYPSIN
1P06 1990-04-15 2.34 STRUCTURE ANALYSIS OF SPECIFICITY. ALPHA-LYTIC PROTEASE COMPLEXES WITH ANALOGUES OF REACTION INTERMEDIATES
3I29 2010-06-16 2.4 Crystal structure of a binary complex between an mutant trypsin inhibitor with bovine trypsin
4PRO 1999-05-18 2.4 ALPHA-LYTIC PROTEASE COMPLEXED WITH PRO REGION
3UQV 2012-11-21 2.4 Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor
6B6O 2018-02-21 2.4 Orthorhombic trypsin cryocooled to 100 K with 20% xylose as cryoprotectant
3E8L 2009-07-28 2.48 The Crystal Structure of the Double-headed Arrowhead Protease Inhibitor A in Complex with Two Trypsins
1K1L 2001-11-28 2.5 BOVINE TRYPSIN-INHIBITOR COMPLEX
2F3C 2006-12-05 2.5 Crystal structure of infestin 1, a Kazal-type serineprotease inhibitor, in complex with trypsin
1P04 1990-04-15 2.55 STRUCTURE ANALYSIS OF SPECIFICITY. ALPHA-LYTIC PROTEASE COMPLEXES WITH ANALOGUES OF REACTION INTERMEDIATES
2QYI 2008-08-19 2.6 Crystal structure of a binary complex between an engineered trypsin inhibitor and Bovine trypsin
1EZX 2000-10-25 2.6 CRYSTAL STRUCTURE OF A SERPIN:PROTEASE COMPLEX
2TLD 1992-07-15 2.6 CRYSTAL STRUCTURE OF AN ENGINEERED SUBTILISIN INHIBITOR COMPLEXED WITH BOVINE TRYPSIN
5GIB 2016-08-10 2.7 Succinic acid bound trypsin crystallized as dimer
5GXP 2016-11-02 2.8 Cationic Trypsin With GOL/PGE as Dimer at pH 4.6
3T28 2011-12-28 2.8 TMAO-grown trypsin (bovine)-previously unreported tetragonal crystal form
4NIY 2014-02-19 2.84 Crystal structure of trypsiligase (K60E/N143H/Y151H/D189K trypsin) complexed to YRH-ecotin (M84Y/M85R/A86H ecotin)
2PRO 1999-04-27 3.0 PRO REGION OF ALPHA-LYTIC PROTEASE
2QN5 2008-07-22 3.0 Crystal Structure and Functional Study of the Bowman-Birk Inhibitor from Rice Bran in Complex with Bovine Trypsin
1QL8 2000-08-25 3.0 FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
3UY9 2012-12-12 3.22 Bovine trypsin variant X(tripleGlu217Phe227) in complex with small molecule inhibitor
1C9T 2000-08-03 3.3 COMPLEX OF BDELLASTASIN WITH BOVINE TRYPSIN
6DWU 2019-01-30 3.96 Crystal structure of complex of BBKI and Bovine Trypsin

Relevant UniProtKB Entries

Percent Identity Matching Chains Protein Accession Entry Name
100.0 Anionic trypsin Q29463 TRY2_BOVIN
397.8 A,B,C,D Alpha-lytic protease P00778 PRLA_LYSEN
192.0 A,B Alpha-lytic protease P27459 PRLA_ACHLY
100.0 Cationic trypsin P00760 TRY1_BOVIN
100.0 Streptogrisin-B P00777 PRTB_STRGR
91.3 I Streptogrisin-B P84813 POTM1_SOLTU
92.2 I Streptogrisin-B Q00782 IP2X_SOLTU
96.0 I Streptogrisin-B Q41488 IP25_SOLTU
100.0 I Streptogrisin-B P01080 IP2K_SOLTU